From b9b87881a61a8db4dd632a5dc82d9003ea9a91b7 Mon Sep 17 00:00:00 2001
From: walkowif <walkowif@users.noreply.github.com>
Date: Mon, 25 Sep 2023 11:39:04 +0000
Subject: [PATCH] deploy: a6771e5895c543661145feafcea5f22e4a0ad5ed

---
 stable/appendix/reproducibility.html          | 1928 ++++++++
 stable/assets/css/style.scss                  |   47 +
 stable/assets/img/logo-nest.png               |  Bin 0 -> 1913804 bytes
 stable/assets/img/tlgc.png                    |  Bin 0 -> 1822470 bytes
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 .../lock/tables/medical-history/mht01.lock    | 2757 ++++++++++++
 .../lock/tables/pharmacokinetic/pkct01.lock   |  398 ++
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 .../www/lock/tables/vital-signs/vst01.lock    | 2757 ++++++++++++
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 stable/assets/www/renv.lock                   | 3316 ++++++++++++++
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 .../fstg01_files/figure-html/teal-1.png       |  Bin 0 -> 7498 bytes
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 .../fstg02_files/figure-html/teal-1.png       |  Bin 0 -> 7533 bytes
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 stable/graphs/efficacy/mmrmg01.html           | 2334 ++++++++++
 .../mmrmg01_files/figure-html/plot1-1.png     |  Bin 0 -> 59592 bytes
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 stable/graphs/efficacy/mmrmg02.html           | 2222 +++++++++
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 .../other/brg01_files/figure-html/plot1-1.png |  Bin 0 -> 46784 bytes
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 stable/graphs/other/bwg01.html                | 2858 ++++++++++++
 .../other/bwg01_files/figure-html/plot1-1.png |  Bin 0 -> 46588 bytes
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 stable/graphs/other/cig01.html                | 2443 ++++++++++
 .../cig01_files/figure-html/plot1and2-1.png   |  Bin 0 -> 53320 bytes
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 stable/graphs/other/kmg01.html                | 2347 ++++++++++
 .../other/kmg01_files/figure-html/plot1-1.png |  Bin 0 -> 185678 bytes
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
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+  <a href="../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+</li>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+<li class="sidebar-item">
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+<li class="sidebar-item">
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+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="true">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../appendix/reproducibility.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">Reproducibility</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<section id="session-info" class="level2"><h2 class="anchored" data-anchor-id="session-info">Session Info</h2>
+<div class="cell" data-hash="reproducibility_cache/html/sessioninfo_69d204d4721c97701dab178c3637f650">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+loaded via a namespace (and not attached):
+ [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    
+ [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  
+ [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   
+[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    
+[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2</code></pre>
+</div>
+</div>
+<section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="reproducibility_cache/html/snapshot_b37816cbe533dcc15579a2c7f92521cc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb3-3"><a href="#cb3-3"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(<span class="st">".."</span>, <span class="at">lockfile =</span> <span class="st">"../assets/www/renv.lock"</span>, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb3-4"><a href="#cb3-4"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>
+NOTE: Dependency discovery took 18 seconds during snapshot.
+Consider using .renvignore to ignore files, or switching to explicit snapshots.
+See `?renv::dependencies` for more information.</code></pre>
+</div>
+</div>
+<p><a href="../assets/www/renv.lock">Download</a></p>
+
+
+<!-- -->
+
+</section></section></main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
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+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
+    } else {
+      localAlternateSentinel = value;
+    }
+  }
+  const getColorSchemeSentinel = () => {
+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb5" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb5-1"><a href="#cb5-1"></a><span class="co">---</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a><span class="an">title:</span><span class="co"> Reproducibility</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a><span class="co">---</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a></span>
+<span id="cb5-5"><a href="#cb5-5"></a>------------------------------------------------------------------------</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>{{&lt; include ../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb5-8"><a href="#cb5-8"></a></span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">## Session Info</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a></span>
+<span id="cb5-11"><a href="#cb5-11"></a><span class="in">```{r sessioninfo, message=FALSE}</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb5-13"><a href="#cb5-13"></a></span>
+<span id="cb5-14"><a href="#cb5-14"></a><span class="fu">sessionInfo</span>()</span>
+<span id="cb5-15"><a href="#cb5-15"></a><span class="in">```</span></span>
+<span id="cb5-16"><a href="#cb5-16"></a></span>
+<span id="cb5-17"><a href="#cb5-17"></a><span class="fu">### `.lock` file</span></span>
+<span id="cb5-18"><a href="#cb5-18"></a></span>
+<span id="cb5-19"><a href="#cb5-19"></a>Download the <span class="in">`.lock`</span> file and use <span class="co">[</span><span class="ot">`renv::restore()`</span><span class="co">](https://rstudio.github.io/renv/reference/restore.html)</span> on it to recreate environment used to generate this website.</span>
+<span id="cb5-20"><a href="#cb5-20"></a></span>
+<span id="cb5-21"><a href="#cb5-21"></a><span class="in">```{r snapshot, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb5-22"><a href="#cb5-22"></a><span class="co">#| code-fold: true</span></span>
+<span id="cb5-23"><a href="#cb5-23"></a><span class="co">#| renv.ignore: TRUE</span></span>
+<span id="cb5-24"><a href="#cb5-24"></a></span>
+<span id="cb5-25"><a href="#cb5-25"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb5-26"><a href="#cb5-26"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb5-27"><a href="#cb5-27"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(<span class="st">".."</span>, <span class="at">lockfile =</span> <span class="st">"../assets/www/renv.lock"</span>, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb5-28"><a href="#cb5-28"></a>)</span>
+<span id="cb5-29"><a href="#cb5-29"></a><span class="in">```</span></span>
+<span id="cb5-30"><a href="#cb5-30"></a></span>
+<span id="cb5-31"><a href="#cb5-31"></a><span class="co">[</span><span class="ot">Download</span><span class="co">](../assets/www/renv.lock)</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/assets/css/style.scss b/stable/assets/css/style.scss
new file mode 100644
index 0000000000..2de6003211
--- /dev/null
+++ b/stable/assets/css/style.scss
@@ -0,0 +1,47 @@
+/*-- scss:defaults --*/
+
+$primary:  #0B41CD !default;
+$fg: #000000 !default;
+$bg: #ffffff !default;
+
+/*-- scss:rules --*/
+
+img.quarto-cover-image {
+  box-shadow: 0 .5rem 1rem rgba(0,0,0,.15);
+}
+
+pre {
+  background-color: rgba(233, 236, 239, 0.65);
+}
+
+code {
+  color: inherit;
+}
+
+.navbar {
+  height: 40px;
+}
+
+.panel-tabset .nav-item {
+  font-size: 16px;
+  font-style: normal;
+}
+
+#quarto-document-content {
+	width: 110%;
+	margin-left: 150px;
+}
+.sidebar {
+	margin-left: 150px;
+}
+.sidebar.margin-sidebar {
+  margin-left: 250px;
+  width: 250px;
+}
+.page-navigation.column-page-right {
+  margin-left: 250px;
+}
+/* -- Giscus content --*/
+.giscus {
+	margin-left: 75px;
+}
diff --git a/stable/assets/img/logo-nest.png b/stable/assets/img/logo-nest.png
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new file mode 100644
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diff --git a/stable/assets/www/lock/graphs/other/cig01.lock b/stable/assets/www/lock/graphs/other/cig01.lock
new file mode 100644
index 0000000000..5e62f75181
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new file mode 100644
index 0000000000..5e62f75181
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diff --git a/stable/assets/www/lock/graphs/pharmacokinetic/pkcg01.lock b/stable/assets/www/lock/graphs/pharmacokinetic/pkcg01.lock
new file mode 100644
index 0000000000..ebf78c0e07
--- /dev/null
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new file mode 100644
index 0000000000..ebf78c0e07
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diff --git a/stable/assets/www/lock/graphs/pharmacokinetic/pkcg03.lock b/stable/assets/www/lock/graphs/pharmacokinetic/pkcg03.lock
new file mode 100644
index 0000000000..ebf78c0e07
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new file mode 100644
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new file mode 100644
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new file mode 100644
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new file mode 100644
index 0000000000..ebf78c0e07
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new file mode 100644
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diff --git a/stable/assets/www/lock/listings/ECG/egl01.lock b/stable/assets/www/lock/listings/ECG/egl01.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
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new file mode 100644
index 0000000000..2934210114
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/adverse-events/ael01_nollt.lock b/stable/assets/www/lock/listings/adverse-events/ael01_nollt.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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index 0000000000..fb1763d83d
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diff --git a/stable/assets/www/lock/listings/adverse-events/ael03.lock b/stable/assets/www/lock/listings/adverse-events/ael03.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/adverse-events/ael04.lock b/stable/assets/www/lock/listings/adverse-events/ael04.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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index 0000000000..2934210114
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diff --git a/stable/assets/www/lock/listings/concomitant-medications/cml02b_gl.lock b/stable/assets/www/lock/listings/concomitant-medications/cml02b_gl.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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new file mode 100644
index 0000000000..2934210114
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new file mode 100644
index 0000000000..2934210114
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/efficacy/oncl01.lock b/stable/assets/www/lock/listings/efficacy/oncl01.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
+++ b/stable/assets/www/lock/listings/efficacy/oncl01.lock
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new file mode 100644
index 0000000000..2934210114
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diff --git a/stable/assets/www/lock/listings/lab-results/lbl01.lock b/stable/assets/www/lock/listings/lab-results/lbl01.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
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index 0000000000..9d7e952cfa
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new file mode 100644
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diff --git a/stable/assets/www/lock/listings/lab-results/lbl02b.lock b/stable/assets/www/lock/listings/lab-results/lbl02b.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/medical-history/mhl01.lock b/stable/assets/www/lock/listings/medical-history/mhl01.lock
new file mode 100644
index 0000000000..2934210114
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/pharmacokinetic/pkpl01.lock b/stable/assets/www/lock/listings/pharmacokinetic/pkpl01.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
+++ b/stable/assets/www/lock/listings/pharmacokinetic/pkpl01.lock
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diff --git a/stable/assets/www/lock/listings/pharmacokinetic/pkpl02.lock b/stable/assets/www/lock/listings/pharmacokinetic/pkpl02.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
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diff --git a/stable/assets/www/lock/listings/pharmacokinetic/pkpl04.lock b/stable/assets/www/lock/listings/pharmacokinetic/pkpl04.lock
new file mode 100644
index 0000000000..9d7e952cfa
--- /dev/null
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
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new file mode 100644
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
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new file mode 100644
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new file mode 100644
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index 0000000000..3c6926c253
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index 0000000000..3c6926c253
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new file mode 100644
index 0000000000..3c6926c253
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new file mode 100644
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new file mode 100644
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new file mode 100644
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new file mode 100644
index 0000000000..3c6926c253
--- /dev/null
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
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new file mode 100644
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new file mode 100644
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new file mode 100644
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new file mode 100644
index 0000000000..3c6926c253
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new file mode 100644
index 0000000000..79e0bc623d
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new file mode 100644
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diff --git a/stable/assets/www/lock/tables/pharmacokinetic/pkct01.lock b/stable/assets/www/lock/tables/pharmacokinetic/pkct01.lock
new file mode 100644
index 0000000000..40c54dea9a
--- /dev/null
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new file mode 100644
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new file mode 100644
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new file mode 100644
index 0000000000..79e0bc623d
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diff --git a/stable/assets/www/lock/tables/pharmacokinetic/pkpt11.lock b/stable/assets/www/lock/tables/pharmacokinetic/pkpt11.lock
new file mode 100644
index 0000000000..79e0bc623d
--- /dev/null
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new file mode 100644
index 0000000000..3c6926c253
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new file mode 100644
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new file mode 100644
index 0000000000..3c6926c253
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new file mode 100644
index 0000000000..f466abcaab
--- /dev/null
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">FSTG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Subgroup Analysis of Best Overall Response</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Plot</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot Specifying Class Variables and <br> Options for the Treatment Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot Selecting Columns and <br> Changing the Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot with Fixed <br> Symbol Size</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Plot of CR Only, Setting <br> Values Indicating Response</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="fstg01_cache/html/setup_7a8be4172f8640e1998cd4f84bf12cc8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARMCD, ARM, SEX, BMRKR2, STRATA1, STRATA2)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adrs_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>anl <span class="ot">&lt;-</span> <span class="fu">inner_join</span>(adsl_f, adrs_f, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb1-14"><a href="#cb1-14"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>anl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(anl)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>anl_rsp_arms_ab <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="fu">droplevels</span>(),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb1-27"><a href="#cb1-27"></a><span class="fu">var_labels</span>(anl_rsp_arms_ab) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is Responder"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="fstg01_cache/html/unnamed-chunk-1_b9c78ae13855fa2c9a12e81eee8add07">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  ),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>)</span>
+<span id="cb2-11"><a href="#cb2-11"></a></span>
+<span id="cb2-12"><a href="#cb2-12"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb2-17"><a href="#cb2-17"></a>)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/unnamed-chunk-1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-hash="fstg01_cache/html/unnamed-chunk-2_965f146cd7f1e8364d58a497febf6a68">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>anl_rsp_comb_arms_ac <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb3-5"><a href="#cb3-5"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>      <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>      <span class="fu">combine_levels</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)),</span>
+<span id="cb3-8"><a href="#cb3-8"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-9"><a href="#cb3-9"></a>      <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-10"><a href="#cb3-10"></a>      <span class="fu">combine_levels</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)),</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="co"># reorder levels of SEX</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb3-13"><a href="#cb3-13"></a>    <span class="co"># reorder levels of STRATA1 by frequency</span></span>
+<span id="cb3-14"><a href="#cb3-14"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb3-15"><a href="#cb3-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-16"><a href="#cb3-16"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb3-17"><a href="#cb3-17"></a><span class="fu">var_labels</span>(anl_rsp_comb_arms_ac) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is Responder"</span>)</span>
+<span id="cb3-18"><a href="#cb3-18"></a></span>
+<span id="cb3-19"><a href="#cb3-19"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb3-20"><a href="#cb3-20"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb3-21"><a href="#cb3-21"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb3-22"><a href="#cb3-22"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb3-23"><a href="#cb3-23"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb3-24"><a href="#cb3-24"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb3-25"><a href="#cb3-25"></a>  ),</span>
+<span id="cb3-26"><a href="#cb3-26"></a>  <span class="at">data =</span> anl_rsp_comb_arms_ac,</span>
+<span id="cb3-27"><a href="#cb3-27"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb3-28"><a href="#cb3-28"></a>)</span>
+<span id="cb3-29"><a href="#cb3-29"></a></span>
+<span id="cb3-30"><a href="#cb3-30"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-31"><a href="#cb3-31"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb3-32"><a href="#cb3-32"></a></span>
+<span id="cb3-33"><a href="#cb3-33"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb3-34"><a href="#cb3-34"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb3-35"><a href="#cb3-35"></a>)</span>
+<span id="cb3-36"><a href="#cb3-36"></a></span>
+<span id="cb3-37"><a href="#cb3-37"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/unnamed-chunk-2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-hash="fstg01_cache/html/unnamed-chunk-3_a9583f717a3e8081fd794b04483f98c2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  ),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="at">conf_level =</span> <span class="fl">0.90</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb4-14"><a href="#cb4-14"></a></span>
+<span id="cb4-15"><a href="#cb4-15"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb4-17"><a href="#cb4-17"></a>)</span>
+<span id="cb4-18"><a href="#cb4-18"></a></span>
+<span id="cb4-19"><a href="#cb4-19"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/unnamed-chunk-3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-hash="fstg01_cache/html/unnamed-chunk-4_a128da34c989265a2e6d02b574f8d50b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb5-3"><a href="#cb5-3"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb5-6"><a href="#cb5-6"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>  ),</span>
+<span id="cb5-8"><a href="#cb5-8"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a>)</span>
+<span id="cb5-11"><a href="#cb5-11"></a></span>
+<span id="cb5-12"><a href="#cb5-12"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-13"><a href="#cb5-13"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb5-14"><a href="#cb5-14"></a></span>
+<span id="cb5-15"><a href="#cb5-15"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb5-16"><a href="#cb5-16"></a>  <span class="at">tbl =</span> result,</span>
+<span id="cb5-17"><a href="#cb5-17"></a>  <span class="at">col_symbol_size =</span> <span class="cn">NULL</span></span>
+<span id="cb5-18"><a href="#cb5-18"></a>)</span>
+<span id="cb5-19"><a href="#cb5-19"></a></span>
+<span id="cb5-20"><a href="#cb5-20"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/unnamed-chunk-4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-hash="fstg01_cache/html/unnamed-chunk-5_a7b89e769952f56a69029d9034f79693">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>anl_cr_arms_ab <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>      <span class="fu">droplevels</span>(),</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb6-11"><a href="#cb6-11"></a><span class="fu">var_labels</span>(anl_cr_arms_ab) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is CR"</span>)</span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  ),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="at">data =</span> anl_cr_arms_ab,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>)</span>
+<span id="cb6-23"><a href="#cb6-23"></a></span>
+<span id="cb6-24"><a href="#cb6-24"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb6-26"><a href="#cb6-26"></a></span>
+<span id="cb6-27"><a href="#cb6-27"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb6-29"><a href="#cb6-29"></a>)</span>
+<span id="cb6-30"><a href="#cb6-30"></a></span>
+<span id="cb6-31"><a href="#cb6-31"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/unnamed-chunk-5-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="fstg01_cache/html/teal_7ed15ff448237f9b7ebcf1952af819b2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-3"><a href="#cb7-3"></a></span>
+<span id="cb7-4"><a href="#cb7-4"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb7-5"><a href="#cb7-5"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb7-6"><a href="#cb7-6"></a></span>
+<span id="cb7-7"><a href="#cb7-7"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb7-8"><a href="#cb7-8"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb7-10"><a href="#cb7-10"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>  ),</span>
+<span id="cb7-12"><a href="#cb7-12"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb7-15"><a href="#cb7-15"></a>  )</span>
+<span id="cb7-16"><a href="#cb7-16"></a>)</span>
+<span id="cb7-17"><a href="#cb7-17"></a></span>
+<span id="cb7-18"><a href="#cb7-18"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb7-19"><a href="#cb7-19"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb7-20"><a href="#cb7-20"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb7-21"><a href="#cb7-21"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, ADRS, <span class="at">code =</span> <span class="st">'ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs")'</span>),</span>
+<span id="cb7-22"><a href="#cb7-22"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  ),</span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="fu">tm_g_forest_rsp</span>(</span>
+<span id="cb7-26"><a href="#cb7-26"></a>      <span class="at">label =</span> <span class="st">"Forest Response"</span>,</span>
+<span id="cb7-27"><a href="#cb7-27"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb7-28"><a href="#cb7-28"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb7-29"><a href="#cb7-29"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb7-30"><a href="#cb7-30"></a>        <span class="st">"ARMCD"</span></span>
+<span id="cb7-31"><a href="#cb7-31"></a>      ),</span>
+<span id="cb7-32"><a href="#cb7-32"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb7-34"><a href="#cb7-34"></a>        <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb7-35"><a href="#cb7-35"></a>        <span class="st">"BESRSPI"</span></span>
+<span id="cb7-36"><a href="#cb7-36"></a>      ),</span>
+<span id="cb7-37"><a href="#cb7-37"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb7-38"><a href="#cb7-38"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">names</span>(ADSL)),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>        <span class="fu">c</span>(<span class="st">"BMRKR2"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb7-40"><a href="#cb7-40"></a>      ),</span>
+<span id="cb7-41"><a href="#cb7-41"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb7-42"><a href="#cb7-42"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)),</span>
+<span id="cb7-43"><a href="#cb7-43"></a>        <span class="st">"STRATA2"</span></span>
+<span id="cb7-44"><a href="#cb7-44"></a>      ),</span>
+<span id="cb7-45"><a href="#cb7-45"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(600L, 200L, 2000L),</span>
+<span id="cb7-46"><a href="#cb7-46"></a>      <span class="at">plot_width =</span> <span class="fu">c</span>(1100L, 200L, 2000L)</span>
+<span id="cb7-47"><a href="#cb7-47"></a>    )</span>
+<span id="cb7-48"><a href="#cb7-48"></a>  )</span>
+<span id="cb7-49"><a href="#cb7-49"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:46:52.0233 pid:4888 token:[] teal.modules.clinical Initializing tm_g_forest_rsp</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="fstg01_cache/html/sessioninfo_727a11e576a704067ae72a460e3f2009">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+[13] scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       R6_2.5.1              Rdpack_2.5           
+[67] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[70] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[73] teal.reporter_0.2.1   httpuv_1.6.11         bslib_0.5.1          
+[76] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[79] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[82] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="fstg01_cache/html/snapshot_e1d680d80d88d6e04d47a5f16aed5975">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-2"><a href="#cb12-2"></a></span>
+<span id="cb12-3"><a href="#cb12-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-10"><a href="#cb12-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-11"><a href="#cb12-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/efficacy/fstg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
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+      } else {
+        el.classList.add('notransition');
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+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
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+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
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+          toggle.classList.remove("alternate");
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+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
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+    return window.location.protocol === 'file:';
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+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
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+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
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+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+        }
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+  });
+  clipboard.on('success', function(e) {
+    // button target
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+    // flash "checked"
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+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
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+      button.setAttribute("data-bs-title", "Copied!");
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+        { trigger: "manual", 
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+    }
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+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
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+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
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+      return false;
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+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
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+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
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+        if (codeDiv.classList.contains(fromCls)) {
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+          codeDiv.classList.add(toCls);
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+      return false;
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+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
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+  if (showAllCode) {
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+  }
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+      interactive: true,
+      interactiveBorder: 10,
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+  }
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+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+<div class="sourceCode" id="cb13" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb13-1"><a href="#cb13-1"></a><span class="co">---</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a><span class="an">title:</span><span class="co"> FSTG01</span></span>
+<span id="cb13-3"><a href="#cb13-3"></a><span class="an">subtitle:</span><span class="co"> Subgroup Analysis of Best Overall Response</span></span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="co">---</span></span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>------------------------------------------------------------------------</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>::: panel-tabset</span>
+<span id="cb13-9"><a href="#cb13-9"></a><span class="fu">## Data Setup</span></span>
+<span id="cb13-10"><a href="#cb13-10"></a></span>
+<span id="cb13-11"><a href="#cb13-11"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb13-12"><a href="#cb13-12"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb13-13"><a href="#cb13-13"></a></span>
+<span id="cb13-14"><a href="#cb13-14"></a><span class="fu">library</span>(scda)</span>
+<span id="cb13-15"><a href="#cb13-15"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb13-16"><a href="#cb13-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb13-17"><a href="#cb13-17"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb13-18"><a href="#cb13-18"></a></span>
+<span id="cb13-19"><a href="#cb13-19"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-20"><a href="#cb13-20"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARMCD, ARM, SEX, BMRKR2, STRATA1, STRATA2)</span>
+<span id="cb13-21"><a href="#cb13-21"></a></span>
+<span id="cb13-22"><a href="#cb13-22"></a>adrs_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-23"><a href="#cb13-23"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-24"><a href="#cb13-24"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)</span>
+<span id="cb13-25"><a href="#cb13-25"></a></span>
+<span id="cb13-26"><a href="#cb13-26"></a>anl <span class="ot">&lt;-</span> <span class="fu">inner_join</span>(adsl_f, adrs_f, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb13-27"><a href="#cb13-27"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span>
+<span id="cb13-28"><a href="#cb13-28"></a>anl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(anl)</span>
+<span id="cb13-29"><a href="#cb13-29"></a></span>
+<span id="cb13-30"><a href="#cb13-30"></a>anl_rsp_arms_ab <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb13-31"><a href="#cb13-31"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-32"><a href="#cb13-32"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-33"><a href="#cb13-33"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb13-34"><a href="#cb13-34"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-35"><a href="#cb13-35"></a>      <span class="fu">droplevels</span>(),</span>
+<span id="cb13-36"><a href="#cb13-36"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-37"><a href="#cb13-37"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb13-38"><a href="#cb13-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-39"><a href="#cb13-39"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb13-40"><a href="#cb13-40"></a><span class="fu">var_labels</span>(anl_rsp_arms_ab) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is Responder"</span>)</span>
+<span id="cb13-41"><a href="#cb13-41"></a><span class="in">```</span></span>
+<span id="cb13-42"><a href="#cb13-42"></a></span>
+<span id="cb13-43"><a href="#cb13-43"></a><span class="fu">## Standard Plot</span></span>
+<span id="cb13-44"><a href="#cb13-44"></a></span>
+<span id="cb13-45"><a href="#cb13-45"></a><span class="in">```{r, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb13-46"><a href="#cb13-46"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb13-47"><a href="#cb13-47"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb13-48"><a href="#cb13-48"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb13-49"><a href="#cb13-49"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb13-50"><a href="#cb13-50"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb13-51"><a href="#cb13-51"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb13-52"><a href="#cb13-52"></a>  ),</span>
+<span id="cb13-53"><a href="#cb13-53"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb13-54"><a href="#cb13-54"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb13-55"><a href="#cb13-55"></a>)</span>
+<span id="cb13-56"><a href="#cb13-56"></a></span>
+<span id="cb13-57"><a href="#cb13-57"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-58"><a href="#cb13-58"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb13-59"><a href="#cb13-59"></a></span>
+<span id="cb13-60"><a href="#cb13-60"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-61"><a href="#cb13-61"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb13-62"><a href="#cb13-62"></a>)</span>
+<span id="cb13-63"><a href="#cb13-63"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb13-64"><a href="#cb13-64"></a><span class="in">```</span></span>
+<span id="cb13-65"><a href="#cb13-65"></a></span>
+<span id="cb13-66"><a href="#cb13-66"></a><span class="fu">## Plot Specifying Class Variables and &lt;br/&gt; Options for the Treatment Variable</span></span>
+<span id="cb13-67"><a href="#cb13-67"></a></span>
+<span id="cb13-68"><a href="#cb13-68"></a><span class="in">```{r, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb13-69"><a href="#cb13-69"></a>anl_rsp_comb_arms_ac <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb13-70"><a href="#cb13-70"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-71"><a href="#cb13-71"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-72"><a href="#cb13-72"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb13-73"><a href="#cb13-73"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-74"><a href="#cb13-74"></a>      <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-75"><a href="#cb13-75"></a>      <span class="fu">combine_levels</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)),</span>
+<span id="cb13-76"><a href="#cb13-76"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-77"><a href="#cb13-77"></a>      <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-78"><a href="#cb13-78"></a>      <span class="fu">combine_levels</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)),</span>
+<span id="cb13-79"><a href="#cb13-79"></a>    <span class="co"># reorder levels of SEX</span></span>
+<span id="cb13-80"><a href="#cb13-80"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb13-81"><a href="#cb13-81"></a>    <span class="co"># reorder levels of STRATA1 by frequency</span></span>
+<span id="cb13-82"><a href="#cb13-82"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb13-83"><a href="#cb13-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-84"><a href="#cb13-84"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb13-85"><a href="#cb13-85"></a><span class="fu">var_labels</span>(anl_rsp_comb_arms_ac) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is Responder"</span>)</span>
+<span id="cb13-86"><a href="#cb13-86"></a></span>
+<span id="cb13-87"><a href="#cb13-87"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb13-88"><a href="#cb13-88"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb13-89"><a href="#cb13-89"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb13-90"><a href="#cb13-90"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb13-91"><a href="#cb13-91"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb13-92"><a href="#cb13-92"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb13-93"><a href="#cb13-93"></a>  ),</span>
+<span id="cb13-94"><a href="#cb13-94"></a>  <span class="at">data =</span> anl_rsp_comb_arms_ac,</span>
+<span id="cb13-95"><a href="#cb13-95"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb13-96"><a href="#cb13-96"></a>)</span>
+<span id="cb13-97"><a href="#cb13-97"></a></span>
+<span id="cb13-98"><a href="#cb13-98"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-99"><a href="#cb13-99"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb13-100"><a href="#cb13-100"></a></span>
+<span id="cb13-101"><a href="#cb13-101"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-102"><a href="#cb13-102"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb13-103"><a href="#cb13-103"></a>)</span>
+<span id="cb13-104"><a href="#cb13-104"></a></span>
+<span id="cb13-105"><a href="#cb13-105"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb13-106"><a href="#cb13-106"></a><span class="in">```</span></span>
+<span id="cb13-107"><a href="#cb13-107"></a></span>
+<span id="cb13-108"><a href="#cb13-108"></a><span class="fu">## Plot Selecting Columns and &lt;br/&gt; Changing the Alpha Level</span></span>
+<span id="cb13-109"><a href="#cb13-109"></a></span>
+<span id="cb13-110"><a href="#cb13-110"></a><span class="in">```{r, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb13-111"><a href="#cb13-111"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb13-112"><a href="#cb13-112"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb13-113"><a href="#cb13-113"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb13-114"><a href="#cb13-114"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb13-115"><a href="#cb13-115"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb13-116"><a href="#cb13-116"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb13-117"><a href="#cb13-117"></a>  ),</span>
+<span id="cb13-118"><a href="#cb13-118"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb13-119"><a href="#cb13-119"></a>  <span class="at">conf_level =</span> <span class="fl">0.90</span></span>
+<span id="cb13-120"><a href="#cb13-120"></a>)</span>
+<span id="cb13-121"><a href="#cb13-121"></a></span>
+<span id="cb13-122"><a href="#cb13-122"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-123"><a href="#cb13-123"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb13-124"><a href="#cb13-124"></a></span>
+<span id="cb13-125"><a href="#cb13-125"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-126"><a href="#cb13-126"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb13-127"><a href="#cb13-127"></a>)</span>
+<span id="cb13-128"><a href="#cb13-128"></a></span>
+<span id="cb13-129"><a href="#cb13-129"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb13-130"><a href="#cb13-130"></a><span class="in">```</span></span>
+<span id="cb13-131"><a href="#cb13-131"></a></span>
+<span id="cb13-132"><a href="#cb13-132"></a><span class="fu">## Plot with Fixed &lt;br/&gt; Symbol Size</span></span>
+<span id="cb13-133"><a href="#cb13-133"></a></span>
+<span id="cb13-134"><a href="#cb13-134"></a><span class="in">```{r, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb13-135"><a href="#cb13-135"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb13-136"><a href="#cb13-136"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb13-137"><a href="#cb13-137"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb13-138"><a href="#cb13-138"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb13-139"><a href="#cb13-139"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb13-140"><a href="#cb13-140"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb13-141"><a href="#cb13-141"></a>  ),</span>
+<span id="cb13-142"><a href="#cb13-142"></a>  <span class="at">data =</span> anl_rsp_arms_ab,</span>
+<span id="cb13-143"><a href="#cb13-143"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb13-144"><a href="#cb13-144"></a>)</span>
+<span id="cb13-145"><a href="#cb13-145"></a></span>
+<span id="cb13-146"><a href="#cb13-146"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-147"><a href="#cb13-147"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb13-148"><a href="#cb13-148"></a></span>
+<span id="cb13-149"><a href="#cb13-149"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-150"><a href="#cb13-150"></a>  <span class="at">tbl =</span> result,</span>
+<span id="cb13-151"><a href="#cb13-151"></a>  <span class="at">col_symbol_size =</span> <span class="cn">NULL</span></span>
+<span id="cb13-152"><a href="#cb13-152"></a>)</span>
+<span id="cb13-153"><a href="#cb13-153"></a></span>
+<span id="cb13-154"><a href="#cb13-154"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb13-155"><a href="#cb13-155"></a><span class="in">```</span></span>
+<span id="cb13-156"><a href="#cb13-156"></a></span>
+<span id="cb13-157"><a href="#cb13-157"></a><span class="fu">## Plot of CR Only, Setting &lt;br/&gt; Values Indicating Response</span></span>
+<span id="cb13-158"><a href="#cb13-158"></a></span>
+<span id="cb13-159"><a href="#cb13-159"></a><span class="in">```{r, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb13-160"><a href="#cb13-160"></a>anl_cr_arms_ab <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb13-161"><a href="#cb13-161"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-162"><a href="#cb13-162"></a>  <span class="fu">filter</span>(ARMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-163"><a href="#cb13-163"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb13-164"><a href="#cb13-164"></a>    <span class="at">ARMCD =</span> <span class="fu">relevel</span>(ARMCD, <span class="at">ref =</span> <span class="st">"ARM B"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-165"><a href="#cb13-165"></a>      <span class="fu">droplevels</span>(),</span>
+<span id="cb13-166"><a href="#cb13-166"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-167"><a href="#cb13-167"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb13-168"><a href="#cb13-168"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-169"><a href="#cb13-169"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb13-170"><a href="#cb13-170"></a><span class="fu">var_labels</span>(anl_cr_arms_ab) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">is_rsp =</span> <span class="st">"Is CR"</span>)</span>
+<span id="cb13-171"><a href="#cb13-171"></a></span>
+<span id="cb13-172"><a href="#cb13-172"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb13-173"><a href="#cb13-173"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb13-174"><a href="#cb13-174"></a>    <span class="at">rsp =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb13-175"><a href="#cb13-175"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb13-176"><a href="#cb13-176"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb13-177"><a href="#cb13-177"></a>    <span class="at">strata_var =</span> <span class="st">"STRATA2"</span></span>
+<span id="cb13-178"><a href="#cb13-178"></a>  ),</span>
+<span id="cb13-179"><a href="#cb13-179"></a>  <span class="at">data =</span> anl_cr_arms_ab,</span>
+<span id="cb13-180"><a href="#cb13-180"></a>  <span class="at">conf_level =</span> <span class="fl">0.95</span></span>
+<span id="cb13-181"><a href="#cb13-181"></a>)</span>
+<span id="cb13-182"><a href="#cb13-182"></a></span>
+<span id="cb13-183"><a href="#cb13-183"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-184"><a href="#cb13-184"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb13-185"><a href="#cb13-185"></a></span>
+<span id="cb13-186"><a href="#cb13-186"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-187"><a href="#cb13-187"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb13-188"><a href="#cb13-188"></a>)</span>
+<span id="cb13-189"><a href="#cb13-189"></a></span>
+<span id="cb13-190"><a href="#cb13-190"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb13-191"><a href="#cb13-191"></a><span class="in">```</span></span>
+<span id="cb13-192"><a href="#cb13-192"></a></span>
+<span id="cb13-193"><a href="#cb13-193"></a><span class="fu">## `teal` App</span></span>
+<span id="cb13-194"><a href="#cb13-194"></a></span>
+<span id="cb13-195"><a href="#cb13-195"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb13-196"><a href="#cb13-196"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb13-197"><a href="#cb13-197"></a></span>
+<span id="cb13-198"><a href="#cb13-198"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb13-199"><a href="#cb13-199"></a><span class="fu">library</span>(scda)</span>
+<span id="cb13-200"><a href="#cb13-200"></a></span>
+<span id="cb13-201"><a href="#cb13-201"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb13-202"><a href="#cb13-202"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb13-203"><a href="#cb13-203"></a></span>
+<span id="cb13-204"><a href="#cb13-204"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb13-205"><a href="#cb13-205"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb13-206"><a href="#cb13-206"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb13-207"><a href="#cb13-207"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb13-208"><a href="#cb13-208"></a>  ),</span>
+<span id="cb13-209"><a href="#cb13-209"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb13-210"><a href="#cb13-210"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb13-211"><a href="#cb13-211"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb13-212"><a href="#cb13-212"></a>  )</span>
+<span id="cb13-213"><a href="#cb13-213"></a>)</span>
+<span id="cb13-214"><a href="#cb13-214"></a></span>
+<span id="cb13-215"><a href="#cb13-215"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb13-216"><a href="#cb13-216"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb13-217"><a href="#cb13-217"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb13-218"><a href="#cb13-218"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, ADRS, <span class="at">code =</span> <span class="st">'ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs")'</span>),</span>
+<span id="cb13-219"><a href="#cb13-219"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb13-220"><a href="#cb13-220"></a>  ),</span>
+<span id="cb13-221"><a href="#cb13-221"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb13-222"><a href="#cb13-222"></a>    <span class="fu">tm_g_forest_rsp</span>(</span>
+<span id="cb13-223"><a href="#cb13-223"></a>      <span class="at">label =</span> <span class="st">"Forest Response"</span>,</span>
+<span id="cb13-224"><a href="#cb13-224"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb13-225"><a href="#cb13-225"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb13-226"><a href="#cb13-226"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb13-227"><a href="#cb13-227"></a>        <span class="st">"ARMCD"</span></span>
+<span id="cb13-228"><a href="#cb13-228"></a>      ),</span>
+<span id="cb13-229"><a href="#cb13-229"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb13-230"><a href="#cb13-230"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb13-231"><a href="#cb13-231"></a>        <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb13-232"><a href="#cb13-232"></a>        <span class="st">"BESRSPI"</span></span>
+<span id="cb13-233"><a href="#cb13-233"></a>      ),</span>
+<span id="cb13-234"><a href="#cb13-234"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb13-235"><a href="#cb13-235"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">names</span>(ADSL)),</span>
+<span id="cb13-236"><a href="#cb13-236"></a>        <span class="fu">c</span>(<span class="st">"BMRKR2"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb13-237"><a href="#cb13-237"></a>      ),</span>
+<span id="cb13-238"><a href="#cb13-238"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb13-239"><a href="#cb13-239"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)),</span>
+<span id="cb13-240"><a href="#cb13-240"></a>        <span class="st">"STRATA2"</span></span>
+<span id="cb13-241"><a href="#cb13-241"></a>      ),</span>
+<span id="cb13-242"><a href="#cb13-242"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(600L, 200L, 2000L),</span>
+<span id="cb13-243"><a href="#cb13-243"></a>      <span class="at">plot_width =</span> <span class="fu">c</span>(1100L, 200L, 2000L)</span>
+<span id="cb13-244"><a href="#cb13-244"></a>    )</span>
+<span id="cb13-245"><a href="#cb13-245"></a>  )</span>
+<span id="cb13-246"><a href="#cb13-246"></a>)</span>
+<span id="cb13-247"><a href="#cb13-247"></a></span>
+<span id="cb13-248"><a href="#cb13-248"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb13-249"><a href="#cb13-249"></a><span class="in">```</span></span>
+<span id="cb13-250"><a href="#cb13-250"></a></span>
+<span id="cb13-251"><a href="#cb13-251"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb13-252"><a href="#cb13-252"></a></span>
+<span id="cb13-253"><a href="#cb13-253"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">FSTG02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Subgroup Analysis of Survival Duration</p>
+</div>
+
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+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Plot</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot Specifying Class Variables and <br> Options for the Treatment Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot Selecting Columns and <br> Changing the Alpha Level)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot with Fixed <br> Symbol Size</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="fstg02_cache/html/setup_945062988e1f279cc003467f390b3af3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>preprocess_adtte <span class="ot">&lt;-</span> <span class="cf">function</span>(adtte) {</span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="co"># Save variable labels before data processing steps.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  adtte_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adtte)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  adtte <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="fu">df_explicit_na</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>      PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="co"># Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      <span class="co"># Convert time to MONTH</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="at">AVALU =</span> <span class="st">"Months"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="fu">var_relabel</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="at">ARM =</span> adtte_labels[<span class="st">"ARM"</span>],</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      <span class="at">SEX =</span> adtte_labels[<span class="st">"SEX"</span>],</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="at">is_event =</span> <span class="st">"Event Flag"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      <span class="at">AVAL =</span> adtte_labels[<span class="st">"AVAL"</span>],</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="at">AVALU =</span> adtte_labels[<span class="st">"AVALU"</span>]</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    )</span>
+<span id="cb1-34"><a href="#cb1-34"></a></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  adtte</span>
+<span id="cb1-36"><a href="#cb1-36"></a>}</span>
+<span id="cb1-37"><a href="#cb1-37"></a></span>
+<span id="cb1-38"><a href="#cb1-38"></a>anl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">preprocess_adtte</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="fstg02_cache/html/variant1_0d2a744ff36e9e49f4199d0b6d802420">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>anl1 <span class="ot">&lt;-</span> anl</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">data =</span> anl1</span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">df =</span> df,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">time_unit =</span> anl1<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  )</span>
+<span id="cb2-14"><a href="#cb2-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                          B: Placebo               A: Drug X                                    
+                                Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI 
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                      268     134         NA          134         NA              1.00       (0.69, 1.44)
+Sex                                                                                                                  
+  F                               161     82          NA          79          NA              0.79       (0.49, 1.28)
+  M                               107     52          NA          55          9.6             1.39       (0.78, 2.47)
+Categorical Level Biomarker 2                                                                                        
+  LOW                             95      45          NA          50          9.3             1.14       (0.64, 2.02)
+  MEDIUM                          93      56          NA          37          NA              0.97       (0.52, 1.82)
+  HIGH                            80      33          NA          47          NA              0.97       (0.45, 2.12)</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># Add plot.</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb4-4"><a href="#cb4-4"></a>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg02_files/figure-html/variant1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-hash="fstg02_cache/html/variant2_0085a19afe0b069e48ace72edbf65281">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>anl2 <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb5-3"><a href="#cb5-3"></a>    <span class="co"># Recode levels of arm.</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>    <span class="at">ARM =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb5-5"><a href="#cb5-5"></a>      ARM,</span>
+<span id="cb5-6"><a href="#cb5-6"></a>      <span class="st">"Placebo"</span> <span class="ot">=</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb5-7"><a href="#cb5-7"></a>      <span class="st">"Drug X"</span> <span class="ot">=</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb5-8"><a href="#cb5-8"></a>    ),</span>
+<span id="cb5-9"><a href="#cb5-9"></a>    <span class="co"># Reorder levels of `SEX`.</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="co"># Reorder levels of `STRATA1`` by frequency.</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb5-13"><a href="#cb5-13"></a>  )</span>
+<span id="cb5-14"><a href="#cb5-14"></a></span>
+<span id="cb5-15"><a href="#cb5-15"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb5-16"><a href="#cb5-16"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb5-17"><a href="#cb5-17"></a>  <span class="at">data =</span> anl2</span>
+<span id="cb5-18"><a href="#cb5-18"></a>)</span>
+<span id="cb5-19"><a href="#cb5-19"></a></span>
+<span id="cb5-20"><a href="#cb5-20"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-21"><a href="#cb5-21"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb5-22"><a href="#cb5-22"></a>    <span class="at">df =</span> df,</span>
+<span id="cb5-23"><a href="#cb5-23"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb5-24"><a href="#cb5-24"></a>    <span class="at">time_unit =</span> anl2<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb5-25"><a href="#cb5-25"></a>  )</span>
+<span id="cb5-26"><a href="#cb5-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                      Placebo                 Drug X                                      
+                          Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI 
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                268     134         NA          134         NA              1.00       (0.69, 1.44)
+Sex                                                                                                            
+  M                         107     52          NA          55          9.6             1.39       (0.78, 2.47)
+  F                         161     82          NA          79          NA              0.79       (0.49, 1.28)
+Stratification Factor 1                                                                                        
+  C                         94      45          NA          49          NA              0.75       (0.41, 1.38)
+  B                         92      45          NA          47          NA              1.34       (0.71, 2.54)
+  A                         82      44          NA          38          NA              1.02       (0.53, 1.97)</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb7-3"><a href="#cb7-3"></a>)</span>
+<span id="cb7-4"><a href="#cb7-4"></a></span>
+<span id="cb7-5"><a href="#cb7-5"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg02_files/figure-html/variant2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-hash="fstg02_cache/html/variant3_3196464811f5773f544ef1f921ae6a5e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>anl3 <span class="ot">&lt;-</span> anl</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>),</span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="at">data =</span> anl3</span>
+<span id="cb8-7"><a href="#cb8-7"></a>)</span>
+<span id="cb8-8"><a href="#cb8-8"></a></span>
+<span id="cb8-9"><a href="#cb8-9"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">df =</span> df,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>)</span>
+<span id="cb8-13"><a href="#cb8-13"></a>  )</span>
+<span id="cb8-14"><a href="#cb8-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                                                
+                                Total n   Hazard Ratio   90% Wald CI 
+—————————————————————————————————————————————————————————————————————
+All Patients                      268         1.00       (0.74, 1.36)
+Sex                                                                  
+  F                               161         0.79       (0.53, 1.19)
+  M                               107         1.39       (0.86, 2.25)
+Categorical Level Biomarker 2                                        
+  LOW                             95          1.14       (0.71, 1.84)
+  MEDIUM                          93          0.97       (0.58, 1.64)
+  HIGH                            80          0.97       (0.51, 1.87)</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># Add plot.</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb10-4"><a href="#cb10-4"></a>)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg02_files/figure-html/variant3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-hash="fstg02_cache/html/variant4_0b3dbff4465da9b07b386ee323a99a2d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>anl4 <span class="ot">&lt;-</span> anl</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb11-4"><a href="#cb11-4"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb11-5"><a href="#cb11-5"></a>  <span class="at">data =</span> anl4</span>
+<span id="cb11-6"><a href="#cb11-6"></a>)</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb11-10"><a href="#cb11-10"></a>    <span class="at">df =</span> df,</span>
+<span id="cb11-11"><a href="#cb11-11"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb11-12"><a href="#cb11-12"></a>    <span class="at">time_unit =</span> anl4<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb11-13"><a href="#cb11-13"></a>  )</span>
+<span id="cb11-14"><a href="#cb11-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                          B: Placebo               A: Drug X                                    
+                                Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI 
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                      268     134         NA          134         NA              1.00       (0.69, 1.44)
+Sex                                                                                                                  
+  F                               161     82          NA          79          NA              0.79       (0.49, 1.28)
+  M                               107     52          NA          55          9.6             1.39       (0.78, 2.47)
+Categorical Level Biomarker 2                                                                                        
+  LOW                             95      45          NA          50          9.3             1.14       (0.64, 2.02)
+  MEDIUM                          93      56          NA          37          NA              0.97       (0.52, 1.82)
+  HIGH                            80      33          NA          47          NA              0.97       (0.45, 2.12)</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="co"># Add plot.</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb13-3"><a href="#cb13-3"></a>  <span class="at">tbl =</span> result,</span>
+<span id="cb13-4"><a href="#cb13-4"></a>  <span class="at">col_symbol_size =</span> <span class="cn">NULL</span></span>
+<span id="cb13-5"><a href="#cb13-5"></a>)</span>
+<span id="cb13-6"><a href="#cb13-6"></a></span>
+<span id="cb13-7"><a href="#cb13-7"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg02_files/figure-html/variant4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:24}" data-hash="fstg02_cache/html/teal_652a31a34eb4da2b969e31eddedacb2b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-3"><a href="#cb14-3"></a></span>
+<span id="cb14-4"><a href="#cb14-4"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-5"><a href="#cb14-5"></a>ADSL <span class="ot">&lt;-</span> ADSL <span class="sc">%&gt;%</span></span>
+<span id="cb14-6"><a href="#cb14-6"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-7"><a href="#cb14-7"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb14-8"><a href="#cb14-8"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARMCD, <span class="st">"ARM B"</span>)))</span>
+<span id="cb14-9"><a href="#cb14-9"></a>ADSL<span class="sc">$</span>RACE <span class="ot">&lt;-</span> <span class="fu">droplevels</span>(ADSL<span class="sc">$</span>RACE)</span>
+<span id="cb14-10"><a href="#cb14-10"></a></span>
+<span id="cb14-11"><a href="#cb14-11"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb14-12"><a href="#cb14-12"></a>adtte_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(ADTTE)</span>
+<span id="cb14-13"><a href="#cb14-13"></a></span>
+<span id="cb14-14"><a href="#cb14-14"></a>ADTTE <span class="ot">&lt;-</span> ADTTE <span class="sc">%&gt;%</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb14-16"><a href="#cb14-16"></a>    PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb14-17"><a href="#cb14-17"></a>    ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>),</span>
+<span id="cb14-18"><a href="#cb14-18"></a>    SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)</span>
+<span id="cb14-19"><a href="#cb14-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-20"><a href="#cb14-20"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb14-21"><a href="#cb14-21"></a>    <span class="co"># Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb14-22"><a href="#cb14-22"></a>    <span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb14-23"><a href="#cb14-23"></a>    <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb14-24"><a href="#cb14-24"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb14-25"><a href="#cb14-25"></a>    <span class="co"># Convert time to MONTH</span></span>
+<span id="cb14-26"><a href="#cb14-26"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb14-27"><a href="#cb14-27"></a>    <span class="at">AVALU =</span> <span class="st">"Months"</span></span>
+<span id="cb14-28"><a href="#cb14-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-29"><a href="#cb14-29"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb14-30"><a href="#cb14-30"></a>    <span class="at">ARM =</span> adtte_labels[<span class="st">"ARM"</span>],</span>
+<span id="cb14-31"><a href="#cb14-31"></a>    <span class="at">SEX =</span> adtte_labels[<span class="st">"SEX"</span>],</span>
+<span id="cb14-32"><a href="#cb14-32"></a>    <span class="at">is_event =</span> <span class="st">"Event Flag"</span>,</span>
+<span id="cb14-33"><a href="#cb14-33"></a>    <span class="at">AVAL =</span> adtte_labels[<span class="st">"AVAL"</span>],</span>
+<span id="cb14-34"><a href="#cb14-34"></a>    <span class="at">AVALU =</span> adtte_labels[<span class="st">"AVALU"</span>]</span>
+<span id="cb14-35"><a href="#cb14-35"></a>  )</span>
+<span id="cb14-36"><a href="#cb14-36"></a></span>
+<span id="cb14-37"><a href="#cb14-37"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-38"><a href="#cb14-38"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-39"><a href="#cb14-39"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL,</span>
+<span id="cb14-40"><a href="#cb14-40"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb14-41"><a href="#cb14-41"></a><span class="st">      ADSL &lt;- ADSL %&gt;%</span></span>
+<span id="cb14-42"><a href="#cb14-42"></a><span class="st">        dplyr::filter(ARM %in% c("B: Placebo", "A: Drug X")) %&gt;%</span></span>
+<span id="cb14-43"><a href="#cb14-43"></a><span class="st">        dplyr::mutate(ARM = droplevels(forcats::fct_relevel(ARM, "B: Placebo"))) %&gt;%</span></span>
+<span id="cb14-44"><a href="#cb14-44"></a><span class="st">        dplyr::mutate(ARMCD = droplevels(forcats::fct_relevel(ARMCD, "ARM B")))</span></span>
+<span id="cb14-45"><a href="#cb14-45"></a><span class="st">      ADSL$RACE &lt;- droplevels(ADSL$RACE)</span></span>
+<span id="cb14-46"><a href="#cb14-46"></a><span class="st">      '</span></span>
+<span id="cb14-47"><a href="#cb14-47"></a>    ),</span>
+<span id="cb14-48"><a href="#cb14-48"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb14-49"><a href="#cb14-49"></a><span class="st">                  ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte")</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a><span class="st">                  adtte_labels &lt;- var_labels(ADTTE)</span></span>
+<span id="cb14-51"><a href="#cb14-51"></a><span class="st">                  ADTTE &lt;- ADTTE %&gt;%</span></span>
+<span id="cb14-52"><a href="#cb14-52"></a><span class="st">                    dplyr::filter(</span></span>
+<span id="cb14-53"><a href="#cb14-53"></a><span class="st">                      PARAMCD == "OS",</span></span>
+<span id="cb14-54"><a href="#cb14-54"></a><span class="st">                      ARM %in% c("B: Placebo", "A: Drug X"),</span></span>
+<span id="cb14-55"><a href="#cb14-55"></a><span class="st">                      SEX %in% c("M", "F")</span></span>
+<span id="cb14-56"><a href="#cb14-56"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a><span class="st">                    dplyr::mutate(</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a><span class="st">                      # Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb14-59"><a href="#cb14-59"></a><span class="st">                      ARM = droplevels(forcats::fct_relevel(ARM, "B: Placebo")),</span></span>
+<span id="cb14-60"><a href="#cb14-60"></a><span class="st">                      SEX = droplevels(SEX),</span></span>
+<span id="cb14-61"><a href="#cb14-61"></a><span class="st">                      is_event = CNSR == 0,</span></span>
+<span id="cb14-62"><a href="#cb14-62"></a><span class="st">                      # Convert time to MONTH</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a><span class="st">                      AVAL = day2month(AVAL),</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a><span class="st">                      AVALU = "Months"</span></span>
+<span id="cb14-65"><a href="#cb14-65"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb14-66"><a href="#cb14-66"></a><span class="st">                    var_relabel(</span></span>
+<span id="cb14-67"><a href="#cb14-67"></a><span class="st">                      ARM = adtte_labels["ARM"],</span></span>
+<span id="cb14-68"><a href="#cb14-68"></a><span class="st">                      SEX = adtte_labels["SEX"],</span></span>
+<span id="cb14-69"><a href="#cb14-69"></a><span class="st">                      is_event = "Event Flag",</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a><span class="st">                      AVAL = adtte_labels["AVAL"],</span></span>
+<span id="cb14-71"><a href="#cb14-71"></a><span class="st">                      AVALU = adtte_labels["AVALU"]</span></span>
+<span id="cb14-72"><a href="#cb14-72"></a><span class="st">                    )</span></span>
+<span id="cb14-73"><a href="#cb14-73"></a><span class="st">                  '</span>),</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-75"><a href="#cb14-75"></a>  ),</span>
+<span id="cb14-76"><a href="#cb14-76"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-77"><a href="#cb14-77"></a>    <span class="fu">tm_g_forest_tte</span>(</span>
+<span id="cb14-78"><a href="#cb14-78"></a>      <span class="at">label =</span> <span class="st">"Forest Survival"</span>,</span>
+<span id="cb14-79"><a href="#cb14-79"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb14-80"><a href="#cb14-80"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb14-81"><a href="#cb14-81"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(<span class="fu">names</span>(ADSL), <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb14-82"><a href="#cb14-82"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(<span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span>),</span>
+<span id="cb14-83"><a href="#cb14-83"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="st">"STRATA2"</span>),</span>
+<span id="cb14-84"><a href="#cb14-84"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(<span class="dv">600</span>, <span class="dv">200</span>, <span class="dv">2000</span>),</span>
+<span id="cb14-85"><a href="#cb14-85"></a>      <span class="at">plot_width =</span> <span class="fu">c</span>(<span class="dv">1500</span>, <span class="dv">200</span>, <span class="dv">5000</span>)</span>
+<span id="cb14-86"><a href="#cb14-86"></a>    )</span>
+<span id="cb14-87"><a href="#cb14-87"></a>  )</span>
+<span id="cb14-88"><a href="#cb14-88"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:48:28.8738 pid:5106 token:[] teal.modules.clinical Initializing tm_g_forest_tte</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="fstg02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="fstg02_cache/html/sessioninfo_149cb25fff1d8d2a4b2d2714e38c2f62">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   nestcolor_0.1.2             
+ [9] forcats_1.0.0                dplyr_1.1.3                 
+[11] tern_0.9.0                   rtables_0.6.3               
+[13] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       R6_2.5.1              Rdpack_2.5           
+[67] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[70] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[73] teal.reporter_0.2.1   httpuv_1.6.11         bslib_0.5.1          
+[76] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[79] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[82] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="fstg02_cache/html/snapshot_e24c053523e55f5d5e0be12a54a24741">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb19"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb19-1"><a href="#cb19-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb19-2"><a href="#cb19-2"></a></span>
+<span id="cb19-3"><a href="#cb19-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb19-4"><a href="#cb19-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb19-5"><a href="#cb19-5"></a></span>
+<span id="cb19-6"><a href="#cb19-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb19-7"><a href="#cb19-7"></a></span>
+<span id="cb19-8"><a href="#cb19-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb19-9"><a href="#cb19-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb19-10"><a href="#cb19-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb19-11"><a href="#cb19-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/efficacy/fstg02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/efficacy/fstg01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">FSTG01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/efficacy/mmrmg01.html" class="pagination-link">
+        <span class="nav-page-text">MMRMG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb20" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb20-1"><a href="#cb20-1"></a><span class="co">---</span></span>
+<span id="cb20-2"><a href="#cb20-2"></a><span class="an">title:</span><span class="co"> FSTG02</span></span>
+<span id="cb20-3"><a href="#cb20-3"></a><span class="an">subtitle:</span><span class="co"> Subgroup Analysis of Survival Duration</span></span>
+<span id="cb20-4"><a href="#cb20-4"></a><span class="co">---</span></span>
+<span id="cb20-5"><a href="#cb20-5"></a></span>
+<span id="cb20-6"><a href="#cb20-6"></a>------------------------------------------------------------------------</span>
+<span id="cb20-7"><a href="#cb20-7"></a></span>
+<span id="cb20-8"><a href="#cb20-8"></a>::: panel-tabset</span>
+<span id="cb20-9"><a href="#cb20-9"></a><span class="fu">## Data Setup</span></span>
+<span id="cb20-10"><a href="#cb20-10"></a></span>
+<span id="cb20-11"><a href="#cb20-11"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb20-12"><a href="#cb20-12"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb20-13"><a href="#cb20-13"></a></span>
+<span id="cb20-14"><a href="#cb20-14"></a><span class="fu">library</span>(tern)</span>
+<span id="cb20-15"><a href="#cb20-15"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb20-16"><a href="#cb20-16"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb20-17"><a href="#cb20-17"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb20-18"><a href="#cb20-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb20-19"><a href="#cb20-19"></a></span>
+<span id="cb20-20"><a href="#cb20-20"></a>preprocess_adtte <span class="ot">&lt;-</span> <span class="cf">function</span>(adtte) {</span>
+<span id="cb20-21"><a href="#cb20-21"></a>  <span class="co"># Save variable labels before data processing steps.</span></span>
+<span id="cb20-22"><a href="#cb20-22"></a>  adtte_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adtte)</span>
+<span id="cb20-23"><a href="#cb20-23"></a></span>
+<span id="cb20-24"><a href="#cb20-24"></a>  adtte <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb20-25"><a href="#cb20-25"></a>    <span class="fu">df_explicit_na</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb20-26"><a href="#cb20-26"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb20-27"><a href="#cb20-27"></a>      PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb20-28"><a href="#cb20-28"></a>      ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>),</span>
+<span id="cb20-29"><a href="#cb20-29"></a>      SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)</span>
+<span id="cb20-30"><a href="#cb20-30"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-31"><a href="#cb20-31"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb20-32"><a href="#cb20-32"></a>      <span class="co"># Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb20-33"><a href="#cb20-33"></a>      <span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb20-34"><a href="#cb20-34"></a>      <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb20-35"><a href="#cb20-35"></a>      <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb20-36"><a href="#cb20-36"></a>      <span class="co"># Convert time to MONTH</span></span>
+<span id="cb20-37"><a href="#cb20-37"></a>      <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb20-38"><a href="#cb20-38"></a>      <span class="at">AVALU =</span> <span class="st">"Months"</span></span>
+<span id="cb20-39"><a href="#cb20-39"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-40"><a href="#cb20-40"></a>    <span class="fu">var_relabel</span>(</span>
+<span id="cb20-41"><a href="#cb20-41"></a>      <span class="at">ARM =</span> adtte_labels[<span class="st">"ARM"</span>],</span>
+<span id="cb20-42"><a href="#cb20-42"></a>      <span class="at">SEX =</span> adtte_labels[<span class="st">"SEX"</span>],</span>
+<span id="cb20-43"><a href="#cb20-43"></a>      <span class="at">is_event =</span> <span class="st">"Event Flag"</span>,</span>
+<span id="cb20-44"><a href="#cb20-44"></a>      <span class="at">AVAL =</span> adtte_labels[<span class="st">"AVAL"</span>],</span>
+<span id="cb20-45"><a href="#cb20-45"></a>      <span class="at">AVALU =</span> adtte_labels[<span class="st">"AVALU"</span>]</span>
+<span id="cb20-46"><a href="#cb20-46"></a>    )</span>
+<span id="cb20-47"><a href="#cb20-47"></a></span>
+<span id="cb20-48"><a href="#cb20-48"></a>  adtte</span>
+<span id="cb20-49"><a href="#cb20-49"></a>}</span>
+<span id="cb20-50"><a href="#cb20-50"></a></span>
+<span id="cb20-51"><a href="#cb20-51"></a>anl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-52"><a href="#cb20-52"></a>  <span class="fu">preprocess_adtte</span>()</span>
+<span id="cb20-53"><a href="#cb20-53"></a><span class="in">```</span></span>
+<span id="cb20-54"><a href="#cb20-54"></a></span>
+<span id="cb20-55"><a href="#cb20-55"></a><span class="fu">## Standard Plot</span></span>
+<span id="cb20-56"><a href="#cb20-56"></a></span>
+<span id="cb20-57"><a href="#cb20-57"></a><span class="in">```{r variant1, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb20-58"><a href="#cb20-58"></a>anl1 <span class="ot">&lt;-</span> anl</span>
+<span id="cb20-59"><a href="#cb20-59"></a></span>
+<span id="cb20-60"><a href="#cb20-60"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb20-61"><a href="#cb20-61"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-62"><a href="#cb20-62"></a>  <span class="at">data =</span> anl1</span>
+<span id="cb20-63"><a href="#cb20-63"></a>)</span>
+<span id="cb20-64"><a href="#cb20-64"></a></span>
+<span id="cb20-65"><a href="#cb20-65"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb20-66"><a href="#cb20-66"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb20-67"><a href="#cb20-67"></a>    <span class="at">df =</span> df,</span>
+<span id="cb20-68"><a href="#cb20-68"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb20-69"><a href="#cb20-69"></a>    <span class="at">time_unit =</span> anl1<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb20-70"><a href="#cb20-70"></a>  )</span>
+<span id="cb20-71"><a href="#cb20-71"></a>result</span>
+<span id="cb20-72"><a href="#cb20-72"></a></span>
+<span id="cb20-73"><a href="#cb20-73"></a><span class="co"># Add plot.</span></span>
+<span id="cb20-74"><a href="#cb20-74"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb20-75"><a href="#cb20-75"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb20-76"><a href="#cb20-76"></a>)</span>
+<span id="cb20-77"><a href="#cb20-77"></a></span>
+<span id="cb20-78"><a href="#cb20-78"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb20-79"><a href="#cb20-79"></a><span class="in">```</span></span>
+<span id="cb20-80"><a href="#cb20-80"></a></span>
+<span id="cb20-81"><a href="#cb20-81"></a><span class="fu">## Plot Specifying Class Variables and &lt;br/&gt; Options for the Treatment Variable</span></span>
+<span id="cb20-82"><a href="#cb20-82"></a></span>
+<span id="cb20-83"><a href="#cb20-83"></a><span class="in">```{r variant2, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb20-84"><a href="#cb20-84"></a>anl2 <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb20-85"><a href="#cb20-85"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb20-86"><a href="#cb20-86"></a>    <span class="co"># Recode levels of arm.</span></span>
+<span id="cb20-87"><a href="#cb20-87"></a>    <span class="at">ARM =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb20-88"><a href="#cb20-88"></a>      ARM,</span>
+<span id="cb20-89"><a href="#cb20-89"></a>      <span class="st">"Placebo"</span> <span class="ot">=</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb20-90"><a href="#cb20-90"></a>      <span class="st">"Drug X"</span> <span class="ot">=</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb20-91"><a href="#cb20-91"></a>    ),</span>
+<span id="cb20-92"><a href="#cb20-92"></a>    <span class="co"># Reorder levels of `SEX`.</span></span>
+<span id="cb20-93"><a href="#cb20-93"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb20-94"><a href="#cb20-94"></a>    <span class="co"># Reorder levels of `STRATA1`` by frequency.</span></span>
+<span id="cb20-95"><a href="#cb20-95"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb20-96"><a href="#cb20-96"></a>  )</span>
+<span id="cb20-97"><a href="#cb20-97"></a></span>
+<span id="cb20-98"><a href="#cb20-98"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb20-99"><a href="#cb20-99"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb20-100"><a href="#cb20-100"></a>  <span class="at">data =</span> anl2</span>
+<span id="cb20-101"><a href="#cb20-101"></a>)</span>
+<span id="cb20-102"><a href="#cb20-102"></a></span>
+<span id="cb20-103"><a href="#cb20-103"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb20-104"><a href="#cb20-104"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb20-105"><a href="#cb20-105"></a>    <span class="at">df =</span> df,</span>
+<span id="cb20-106"><a href="#cb20-106"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb20-107"><a href="#cb20-107"></a>    <span class="at">time_unit =</span> anl2<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb20-108"><a href="#cb20-108"></a>  )</span>
+<span id="cb20-109"><a href="#cb20-109"></a>result</span>
+<span id="cb20-110"><a href="#cb20-110"></a></span>
+<span id="cb20-111"><a href="#cb20-111"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb20-112"><a href="#cb20-112"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb20-113"><a href="#cb20-113"></a>)</span>
+<span id="cb20-114"><a href="#cb20-114"></a></span>
+<span id="cb20-115"><a href="#cb20-115"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb20-116"><a href="#cb20-116"></a><span class="in">```</span></span>
+<span id="cb20-117"><a href="#cb20-117"></a></span>
+<span id="cb20-118"><a href="#cb20-118"></a><span class="fu">## Plot Selecting Columns and &lt;br/&gt; Changing the Alpha Level)</span></span>
+<span id="cb20-119"><a href="#cb20-119"></a></span>
+<span id="cb20-120"><a href="#cb20-120"></a><span class="in">```{r variant3, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb20-121"><a href="#cb20-121"></a>anl3 <span class="ot">&lt;-</span> anl</span>
+<span id="cb20-122"><a href="#cb20-122"></a></span>
+<span id="cb20-123"><a href="#cb20-123"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb20-124"><a href="#cb20-124"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-125"><a href="#cb20-125"></a>  <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>),</span>
+<span id="cb20-126"><a href="#cb20-126"></a>  <span class="at">data =</span> anl3</span>
+<span id="cb20-127"><a href="#cb20-127"></a>)</span>
+<span id="cb20-128"><a href="#cb20-128"></a></span>
+<span id="cb20-129"><a href="#cb20-129"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb20-130"><a href="#cb20-130"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb20-131"><a href="#cb20-131"></a>    <span class="at">df =</span> df,</span>
+<span id="cb20-132"><a href="#cb20-132"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>)</span>
+<span id="cb20-133"><a href="#cb20-133"></a>  )</span>
+<span id="cb20-134"><a href="#cb20-134"></a>result</span>
+<span id="cb20-135"><a href="#cb20-135"></a></span>
+<span id="cb20-136"><a href="#cb20-136"></a><span class="co"># Add plot.</span></span>
+<span id="cb20-137"><a href="#cb20-137"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb20-138"><a href="#cb20-138"></a>  <span class="at">tbl =</span> result</span>
+<span id="cb20-139"><a href="#cb20-139"></a>)</span>
+<span id="cb20-140"><a href="#cb20-140"></a></span>
+<span id="cb20-141"><a href="#cb20-141"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb20-142"><a href="#cb20-142"></a><span class="in">```</span></span>
+<span id="cb20-143"><a href="#cb20-143"></a></span>
+<span id="cb20-144"><a href="#cb20-144"></a><span class="fu">## Plot with Fixed &lt;br/&gt; Symbol Size</span></span>
+<span id="cb20-145"><a href="#cb20-145"></a></span>
+<span id="cb20-146"><a href="#cb20-146"></a><span class="in">```{r variant4, warning=FALSE, fig.width = 15}</span></span>
+<span id="cb20-147"><a href="#cb20-147"></a>anl4 <span class="ot">&lt;-</span> anl</span>
+<span id="cb20-148"><a href="#cb20-148"></a></span>
+<span id="cb20-149"><a href="#cb20-149"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_survival_subgroups</span>(</span>
+<span id="cb20-150"><a href="#cb20-150"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-151"><a href="#cb20-151"></a>  <span class="at">data =</span> anl4</span>
+<span id="cb20-152"><a href="#cb20-152"></a>)</span>
+<span id="cb20-153"><a href="#cb20-153"></a></span>
+<span id="cb20-154"><a href="#cb20-154"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb20-155"><a href="#cb20-155"></a>  <span class="fu">tabulate_survival_subgroups</span>(</span>
+<span id="cb20-156"><a href="#cb20-156"></a>    <span class="at">df =</span> df,</span>
+<span id="cb20-157"><a href="#cb20-157"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"median"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb20-158"><a href="#cb20-158"></a>    <span class="at">time_unit =</span> anl4<span class="sc">$</span>AVALU[<span class="dv">1</span>]</span>
+<span id="cb20-159"><a href="#cb20-159"></a>  )</span>
+<span id="cb20-160"><a href="#cb20-160"></a>result</span>
+<span id="cb20-161"><a href="#cb20-161"></a></span>
+<span id="cb20-162"><a href="#cb20-162"></a><span class="co"># Add plot.</span></span>
+<span id="cb20-163"><a href="#cb20-163"></a>p <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb20-164"><a href="#cb20-164"></a>  <span class="at">tbl =</span> result,</span>
+<span id="cb20-165"><a href="#cb20-165"></a>  <span class="at">col_symbol_size =</span> <span class="cn">NULL</span></span>
+<span id="cb20-166"><a href="#cb20-166"></a>)</span>
+<span id="cb20-167"><a href="#cb20-167"></a></span>
+<span id="cb20-168"><a href="#cb20-168"></a>grid<span class="sc">::</span><span class="fu">grid.draw</span>(p)</span>
+<span id="cb20-169"><a href="#cb20-169"></a><span class="in">```</span></span>
+<span id="cb20-170"><a href="#cb20-170"></a></span>
+<span id="cb20-171"><a href="#cb20-171"></a><span class="fu">## `teal` App</span></span>
+<span id="cb20-172"><a href="#cb20-172"></a></span>
+<span id="cb20-173"><a href="#cb20-173"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb20-174"><a href="#cb20-174"></a><span class="co">#| screenshot.opts = list(delay = 24)</span></span>
+<span id="cb20-175"><a href="#cb20-175"></a></span>
+<span id="cb20-176"><a href="#cb20-176"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb20-177"><a href="#cb20-177"></a><span class="fu">library</span>(scda)</span>
+<span id="cb20-178"><a href="#cb20-178"></a></span>
+<span id="cb20-179"><a href="#cb20-179"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb20-180"><a href="#cb20-180"></a>ADSL <span class="ot">&lt;-</span> ADSL <span class="sc">%&gt;%</span></span>
+<span id="cb20-181"><a href="#cb20-181"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb20-182"><a href="#cb20-182"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb20-183"><a href="#cb20-183"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARMCD, <span class="st">"ARM B"</span>)))</span>
+<span id="cb20-184"><a href="#cb20-184"></a>ADSL<span class="sc">$</span>RACE <span class="ot">&lt;-</span> <span class="fu">droplevels</span>(ADSL<span class="sc">$</span>RACE)</span>
+<span id="cb20-185"><a href="#cb20-185"></a></span>
+<span id="cb20-186"><a href="#cb20-186"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb20-187"><a href="#cb20-187"></a>adtte_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(ADTTE)</span>
+<span id="cb20-188"><a href="#cb20-188"></a></span>
+<span id="cb20-189"><a href="#cb20-189"></a>ADTTE <span class="ot">&lt;-</span> ADTTE <span class="sc">%&gt;%</span></span>
+<span id="cb20-190"><a href="#cb20-190"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb20-191"><a href="#cb20-191"></a>    PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb20-192"><a href="#cb20-192"></a>    ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>),</span>
+<span id="cb20-193"><a href="#cb20-193"></a>    SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)</span>
+<span id="cb20-194"><a href="#cb20-194"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-195"><a href="#cb20-195"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb20-196"><a href="#cb20-196"></a>    <span class="co"># Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb20-197"><a href="#cb20-197"></a>    <span class="at">ARM =</span> <span class="fu">droplevels</span>(forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb20-198"><a href="#cb20-198"></a>    <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb20-199"><a href="#cb20-199"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb20-200"><a href="#cb20-200"></a>    <span class="co"># Convert time to MONTH</span></span>
+<span id="cb20-201"><a href="#cb20-201"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb20-202"><a href="#cb20-202"></a>    <span class="at">AVALU =</span> <span class="st">"Months"</span></span>
+<span id="cb20-203"><a href="#cb20-203"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-204"><a href="#cb20-204"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb20-205"><a href="#cb20-205"></a>    <span class="at">ARM =</span> adtte_labels[<span class="st">"ARM"</span>],</span>
+<span id="cb20-206"><a href="#cb20-206"></a>    <span class="at">SEX =</span> adtte_labels[<span class="st">"SEX"</span>],</span>
+<span id="cb20-207"><a href="#cb20-207"></a>    <span class="at">is_event =</span> <span class="st">"Event Flag"</span>,</span>
+<span id="cb20-208"><a href="#cb20-208"></a>    <span class="at">AVAL =</span> adtte_labels[<span class="st">"AVAL"</span>],</span>
+<span id="cb20-209"><a href="#cb20-209"></a>    <span class="at">AVALU =</span> adtte_labels[<span class="st">"AVALU"</span>]</span>
+<span id="cb20-210"><a href="#cb20-210"></a>  )</span>
+<span id="cb20-211"><a href="#cb20-211"></a></span>
+<span id="cb20-212"><a href="#cb20-212"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb20-213"><a href="#cb20-213"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb20-214"><a href="#cb20-214"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL,</span>
+<span id="cb20-215"><a href="#cb20-215"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb20-216"><a href="#cb20-216"></a><span class="st">      ADSL &lt;- ADSL %&gt;%</span></span>
+<span id="cb20-217"><a href="#cb20-217"></a><span class="st">        dplyr::filter(ARM %in% c("B: Placebo", "A: Drug X")) %&gt;%</span></span>
+<span id="cb20-218"><a href="#cb20-218"></a><span class="st">        dplyr::mutate(ARM = droplevels(forcats::fct_relevel(ARM, "B: Placebo"))) %&gt;%</span></span>
+<span id="cb20-219"><a href="#cb20-219"></a><span class="st">        dplyr::mutate(ARMCD = droplevels(forcats::fct_relevel(ARMCD, "ARM B")))</span></span>
+<span id="cb20-220"><a href="#cb20-220"></a><span class="st">      ADSL$RACE &lt;- droplevels(ADSL$RACE)</span></span>
+<span id="cb20-221"><a href="#cb20-221"></a><span class="st">      '</span></span>
+<span id="cb20-222"><a href="#cb20-222"></a>    ),</span>
+<span id="cb20-223"><a href="#cb20-223"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb20-224"><a href="#cb20-224"></a><span class="st">                  ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte")</span></span>
+<span id="cb20-225"><a href="#cb20-225"></a><span class="st">                  adtte_labels &lt;- var_labels(ADTTE)</span></span>
+<span id="cb20-226"><a href="#cb20-226"></a><span class="st">                  ADTTE &lt;- ADTTE %&gt;%</span></span>
+<span id="cb20-227"><a href="#cb20-227"></a><span class="st">                    dplyr::filter(</span></span>
+<span id="cb20-228"><a href="#cb20-228"></a><span class="st">                      PARAMCD == "OS",</span></span>
+<span id="cb20-229"><a href="#cb20-229"></a><span class="st">                      ARM %in% c("B: Placebo", "A: Drug X"),</span></span>
+<span id="cb20-230"><a href="#cb20-230"></a><span class="st">                      SEX %in% c("M", "F")</span></span>
+<span id="cb20-231"><a href="#cb20-231"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb20-232"><a href="#cb20-232"></a><span class="st">                    dplyr::mutate(</span></span>
+<span id="cb20-233"><a href="#cb20-233"></a><span class="st">                      # Reorder levels of ARM to display reference arm before treatment arm.</span></span>
+<span id="cb20-234"><a href="#cb20-234"></a><span class="st">                      ARM = droplevels(forcats::fct_relevel(ARM, "B: Placebo")),</span></span>
+<span id="cb20-235"><a href="#cb20-235"></a><span class="st">                      SEX = droplevels(SEX),</span></span>
+<span id="cb20-236"><a href="#cb20-236"></a><span class="st">                      is_event = CNSR == 0,</span></span>
+<span id="cb20-237"><a href="#cb20-237"></a><span class="st">                      # Convert time to MONTH</span></span>
+<span id="cb20-238"><a href="#cb20-238"></a><span class="st">                      AVAL = day2month(AVAL),</span></span>
+<span id="cb20-239"><a href="#cb20-239"></a><span class="st">                      AVALU = "Months"</span></span>
+<span id="cb20-240"><a href="#cb20-240"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb20-241"><a href="#cb20-241"></a><span class="st">                    var_relabel(</span></span>
+<span id="cb20-242"><a href="#cb20-242"></a><span class="st">                      ARM = adtte_labels["ARM"],</span></span>
+<span id="cb20-243"><a href="#cb20-243"></a><span class="st">                      SEX = adtte_labels["SEX"],</span></span>
+<span id="cb20-244"><a href="#cb20-244"></a><span class="st">                      is_event = "Event Flag",</span></span>
+<span id="cb20-245"><a href="#cb20-245"></a><span class="st">                      AVAL = adtte_labels["AVAL"],</span></span>
+<span id="cb20-246"><a href="#cb20-246"></a><span class="st">                      AVALU = adtte_labels["AVALU"]</span></span>
+<span id="cb20-247"><a href="#cb20-247"></a><span class="st">                    )</span></span>
+<span id="cb20-248"><a href="#cb20-248"></a><span class="st">                  '</span>),</span>
+<span id="cb20-249"><a href="#cb20-249"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb20-250"><a href="#cb20-250"></a>  ),</span>
+<span id="cb20-251"><a href="#cb20-251"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb20-252"><a href="#cb20-252"></a>    <span class="fu">tm_g_forest_tte</span>(</span>
+<span id="cb20-253"><a href="#cb20-253"></a>      <span class="at">label =</span> <span class="st">"Forest Survival"</span>,</span>
+<span id="cb20-254"><a href="#cb20-254"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb20-255"><a href="#cb20-255"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb20-256"><a href="#cb20-256"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(<span class="fu">names</span>(ADSL), <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-257"><a href="#cb20-257"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(<span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span>),</span>
+<span id="cb20-258"><a href="#cb20-258"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="st">"STRATA2"</span>),</span>
+<span id="cb20-259"><a href="#cb20-259"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(<span class="dv">600</span>, <span class="dv">200</span>, <span class="dv">2000</span>),</span>
+<span id="cb20-260"><a href="#cb20-260"></a>      <span class="at">plot_width =</span> <span class="fu">c</span>(<span class="dv">1500</span>, <span class="dv">200</span>, <span class="dv">5000</span>)</span>
+<span id="cb20-261"><a href="#cb20-261"></a>    )</span>
+<span id="cb20-262"><a href="#cb20-262"></a>  )</span>
+<span id="cb20-263"><a href="#cb20-263"></a>)</span>
+<span id="cb20-264"><a href="#cb20-264"></a></span>
+<span id="cb20-265"><a href="#cb20-265"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb20-266"><a href="#cb20-266"></a><span class="in">```</span></span>
+<span id="cb20-267"><a href="#cb20-267"></a></span>
+<span id="cb20-268"><a href="#cb20-268"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb20-269"><a href="#cb20-269"></a></span>
+<span id="cb20-270"><a href="#cb20-270"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
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+</li>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
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+</li>
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+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MMRMG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Plots for Mixed-Effect Model Repeated Measures Analysis</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>Given an MMRM fitted with <code>s_mmrm</code>, <code>g_mmrm_lsmeans</code> displays for each visit the adjusted means within group and/or difference in adjusted means between groups. <code>g_mmrm_diagnostic</code> displays marginal residual plots for evaluating model fit.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup and <br> Model Fitting</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Least Squares Means: <br> Estimates Within Groups</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Least Squares Means: <br> Contrasts Between Groups</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Model Diagnostics: Marginal <br> Fitted Values vs.&nbsp;Residuals</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Model Diagnostics: Normality <br> of Marginal Residuals</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mmrmg01_cache/html/setup_d9b4a716d48e19759df2d4eff32d2649">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">factor</span>(ARM, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span> <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>())</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">response =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"STRATA2"</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">data =</span> adqs_f</span>
+<span id="cb1-24"><a href="#cb1-24"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Warning: "automatic" optimizer was deprecated in mmrm 0.2.0.
+ℹ please just omit optimizer argument
+ℹ The deprecated feature was likely used in the mmrm package.
+  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<section id="considering-the-treatment-variable-in-the-model" class="level3"><h3 class="anchored" data-anchor-id="considering-the-treatment-variable-in-the-model">Considering the treatment variable in the model</h3>
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot1_0b795fe8a9d5c51ff3a10f477378e14b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb3-2"><a href="#cb3-2"></a>  mmrm_results,</span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>)</span>
+<span id="cb3-6"><a href="#cb3-6"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="considering-the-treatment-variable-in-the-model-with-lines" class="level3"><h3 class="anchored" data-anchor-id="considering-the-treatment-variable-in-the-model-with-lines">Considering the treatment variable in the model, with lines</h3>
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot2_f2e8ba51f4b764303da5a94986a1b962">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  mmrm_results,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">show_lines =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="considering-the-treatment-variable-in-the-model-with-statistics-table" class="level3"><h3 class="anchored" data-anchor-id="considering-the-treatment-variable-in-the-model-with-statistics-table">Considering the treatment variable in the model, with statistics table</h3>
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot3_8e2affe5192009f7c781afe4efc761a5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  mmrm_results,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="at">table_stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"estimate"</span>, <span class="st">"se"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="at">table_font_size =</span> <span class="dv">4</span>,</span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="at">table_rel_height =</span> <span class="fl">0.6</span></span>
+<span id="cb5-8"><a href="#cb5-8"></a>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Users can choose to display both estimates and contrasts together by running <code>g_mmrm_lsmeans(mmrm_results)</code>.</p>
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot4_0fa4ae21bd758961a02f216b917b38e2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  mmrm_results,</span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="at">select =</span> <span class="st">"contrasts"</span>,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="at">titles =</span> <span class="fu">c</span>(<span class="at">contrasts =</span> <span class="st">"Contrasts of FKSI-FWB means"</span>),</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot5_bb4a1a107eb5f9b2d3f58302c489fa6e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_diagnostic</span>(mmrm_results)</span>
+<span id="cb7-2"><a href="#cb7-2"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot5-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;plot_v6&quot;:&quot;plot&quot;}" data-hash="mmrmg01_cache/html/plot6_481df0215c4e8296f18ce0bd612782c8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_diagnostic</span>(mmrm_results, <span class="at">type =</span> <span class="st">"q-q-residual"</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/plot6-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="mmrmg01_cache/html/teal_ea44a6626f16bebab830087b877e228c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-3"><a href="#cb9-3"></a></span>
+<span id="cb9-4"><a href="#cb9-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-5"><a href="#cb9-5"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-6"><a href="#cb9-6"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-7"><a href="#cb9-7"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-8"><a href="#cb9-8"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>    <span class="at">AVISIT =</span> <span class="fu">as.factor</span>(AVISIT),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb9-11"><a href="#cb9-11"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a>      <span class="fu">as.factor</span>() <span class="co"># making consecutive numeric factor</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a>  )</span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb9-17"><a href="#cb9-17"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb9-18"><a href="#cb9-18"></a>    <span class="at">ref =</span> <span class="st">"ARM A"</span>,</span>
+<span id="cb9-19"><a href="#cb9-19"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb9-20"><a href="#cb9-20"></a>  )</span>
+<span id="cb9-21"><a href="#cb9-21"></a>)</span>
+<span id="cb9-22"><a href="#cb9-22"></a></span>
+<span id="cb9-23"><a href="#cb9-23"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb9-28"><a href="#cb9-28"></a><span class="st">    ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a><span class="st">    ADQS &lt;- synthetic_cdisc_dataset("latest", "adqs") %&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a><span class="st">              dplyr::filter(ABLFL != "Y" &amp; ABLFL2 != "Y") %&gt;%</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a><span class="st">              dplyr::filter(AVISIT %in% c("WEEK 1 DAY 8", "WEEK 2 DAY 15", "WEEK 3 DAY 22")) %&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a><span class="st">              dplyr::mutate(</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a><span class="st">                AVISIT = as.factor(AVISIT),</span></span>
+<span id="cb9-34"><a href="#cb9-34"></a><span class="st">                AVISITN = rank(AVISITN) %&gt;%</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a><span class="st">                  as.factor() %&gt;%</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a><span class="st">                  as.numeric() %&gt;%</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a><span class="st">                  as.factor() # making consecutive numeric factor</span></span>
+<span id="cb9-38"><a href="#cb9-38"></a><span class="st">              )</span></span>
+<span id="cb9-39"><a href="#cb9-39"></a><span class="st">    '</span>,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  ),</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb9-43"><a href="#cb9-43"></a>    <span class="fu">tm_a_mmrm</span>(</span>
+<span id="cb9-44"><a href="#cb9-44"></a>      <span class="at">label =</span> <span class="st">"MMRM"</span>,</span>
+<span id="cb9-45"><a href="#cb9-45"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb9-46"><a href="#cb9-46"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>), <span class="st">"AVAL"</span>),</span>
+<span id="cb9-47"><a href="#cb9-47"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"SUBJID"</span>), <span class="st">"USUBJID"</span>),</span>
+<span id="cb9-48"><a href="#cb9-48"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARMCD"</span>),</span>
+<span id="cb9-49"><a href="#cb9-49"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"AVISITN"</span>), <span class="st">"AVISIT"</span>),</span>
+<span id="cb9-50"><a href="#cb9-50"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb9-51"><a href="#cb9-51"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-52"><a href="#cb9-52"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb9-53"><a href="#cb9-53"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a>      ),</span>
+<span id="cb9-55"><a href="#cb9-55"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"BASE:AVISIT"</span>), <span class="cn">NULL</span>),</span>
+<span id="cb9-56"><a href="#cb9-56"></a>      <span class="at">conf_level =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="fl">0.95</span>, <span class="fl">0.9</span>, <span class="fl">0.8</span>), <span class="fl">0.95</span>)</span>
+<span id="cb9-57"><a href="#cb9-57"></a>    )</span>
+<span id="cb9-58"><a href="#cb9-58"></a>  )</span>
+<span id="cb9-59"><a href="#cb9-59"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:47:41.5751 pid:4991 token:[] teal.modules.clinical Initializing tm_a_mmrm</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mmrmg01_cache/html/sessioninfo_4e709e938ab211270ccfcff14c405713">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              scda_0.1.6                  
+ [9] tern.mmrm_0.2.1              tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] Rdpack_2.5            mmrm_0.2.2            tern.gee_0.1.0       
+ [4] logger_0.2.2          testthat_3.1.10       sandwich_3.0-2       
+ [7] rlang_1.1.1           multcomp_1.4-25       compiler_4.3.1       
+[10] callr_3.7.3           vctrs_0.6.3           stringr_1.5.0        
+[13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      
+[16] ellipsis_0.3.2        fontawesome_0.5.2     labeling_0.4.3       
+[19] utf8_1.2.3            promises_1.2.1        rmarkdown_2.25       
+[22] ps_1.7.5              purrr_1.0.2           xfun_0.40            
+[25] cachem_1.0.8          teal.reporter_0.2.1   jsonlite_1.8.7       
+[28] later_1.3.1           broom_1.0.5           parallel_4.3.1       
+[31] R6_2.5.1              bslib_0.5.1           stringi_1.7.12       
+[34] brio_1.1.3            jquerylib_0.1.4       numDeriv_2016.8-1.1  
+[37] estimability_1.4.1    Rcpp_1.0.11           assertthat_0.2.1     
+[40] knitr_1.44            zoo_1.8-12            teal.logger_0.1.3    
+[43] httpuv_1.6.11         Matrix_1.6-1.1        splines_4.3.1        
+[46] tidyselect_1.2.0      rstudioapi_0.15.0     yaml_2.3.7           
+[49] TMB_1.9.6             codetools_0.2-19      processx_3.8.2       
+[52] teal.widgets_0.4.0    lattice_0.21-8        tibble_3.2.1         
+[55] withr_2.5.0           coda_0.19-4           evaluate_0.21        
+[58] survival_3.5-7        shinycssloaders_1.0.0 pillar_1.9.0         
+[61] checkmate_2.2.0       shinyjs_2.1.0         generics_0.1.3       
+[64] ggplot2_3.4.3         munsell_0.5.0         scales_1.2.1         
+[67] xtable_1.8-4          glue_1.6.2            emmeans_1.8.8        
+[70] tools_4.3.1           webshot_0.5.5         mvtnorm_1.2-3        
+[73] cowplot_1.1.1         grid_4.3.1            tidyr_1.3.0          
+[76] rbibutils_2.2.15      colorspace_2.1-0      nlme_3.1-163         
+[79] cli_3.6.1             fansi_1.0.4           geepack_1.3.9        
+[82] gtable_0.3.4          sass_0.4.7            digest_0.6.33        
+[85] TH.data_1.1-2         htmlwidgets_1.6.2     farver_2.1.1         
+[88] memoise_2.0.1         htmltools_0.5.6       lifecycle_1.0.3      
+[91] shinyWidgets_0.8.0    mime_0.12             MASS_7.3-60          </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mmrmg01_cache/html/snapshot_4aea4cb406171f1ee5a8f877a532c627">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/efficacy/mmrmg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
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+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
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+    }
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+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> MMRMG01</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Plots for Mixed-Effect Model Repeated Measures Analysis</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>Given an MMRM fitted with <span class="in">`s_mmrm`</span>, <span class="in">`g_mmrm_lsmeans`</span> displays for each visit the adjusted means within group and/or difference in adjusted means between groups.</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="in">`g_mmrm_diagnostic`</span> displays marginal residual plots for evaluating model fit.</span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a>::: panel-tabset</span>
+<span id="cb15-14"><a href="#cb15-14"></a><span class="fu">## Data Setup and &lt;br/&gt; Model Fitting</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a></span>
+<span id="cb15-16"><a href="#cb15-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-17"><a href="#cb15-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-18"><a href="#cb15-18"></a></span>
+<span id="cb15-19"><a href="#cb15-19"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-20"><a href="#cb15-20"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb15-21"><a href="#cb15-21"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-22"><a href="#cb15-22"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb15-23"><a href="#cb15-23"></a></span>
+<span id="cb15-24"><a href="#cb15-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-25"><a href="#cb15-25"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb15-26"><a href="#cb15-26"></a></span>
+<span id="cb15-27"><a href="#cb15-27"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb15-28"><a href="#cb15-28"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-29"><a href="#cb15-29"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-30"><a href="#cb15-30"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">factor</span>(ARM, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb15-31"><a href="#cb15-31"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span> <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>())</span>
+<span id="cb15-32"><a href="#cb15-32"></a></span>
+<span id="cb15-33"><a href="#cb15-33"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb15-34"><a href="#cb15-34"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb15-35"><a href="#cb15-35"></a>    <span class="at">response =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb15-36"><a href="#cb15-36"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"STRATA2"</span>),</span>
+<span id="cb15-37"><a href="#cb15-37"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-38"><a href="#cb15-38"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb15-39"><a href="#cb15-39"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb15-40"><a href="#cb15-40"></a>  ),</span>
+<span id="cb15-41"><a href="#cb15-41"></a>  <span class="at">data =</span> adqs_f</span>
+<span id="cb15-42"><a href="#cb15-42"></a>)</span>
+<span id="cb15-43"><a href="#cb15-43"></a><span class="in">```</span></span>
+<span id="cb15-44"><a href="#cb15-44"></a></span>
+<span id="cb15-45"><a href="#cb15-45"></a><span class="fu">## Least Squares Means: &lt;br/&gt; Estimates Within Groups</span></span>
+<span id="cb15-46"><a href="#cb15-46"></a></span>
+<span id="cb15-47"><a href="#cb15-47"></a><span class="fu">### Considering the treatment variable in the model</span></span>
+<span id="cb15-48"><a href="#cb15-48"></a></span>
+<span id="cb15-49"><a href="#cb15-49"></a><span class="in">```{r plot1, dev.args=list(pointsize=6), test = list(plot_v1 = "plot")}</span></span>
+<span id="cb15-50"><a href="#cb15-50"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb15-51"><a href="#cb15-51"></a>  mmrm_results,</span>
+<span id="cb15-52"><a href="#cb15-52"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb15-53"><a href="#cb15-53"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span></span>
+<span id="cb15-54"><a href="#cb15-54"></a>)</span>
+<span id="cb15-55"><a href="#cb15-55"></a>plot</span>
+<span id="cb15-56"><a href="#cb15-56"></a><span class="in">```</span></span>
+<span id="cb15-57"><a href="#cb15-57"></a></span>
+<span id="cb15-58"><a href="#cb15-58"></a><span class="fu">### Considering the treatment variable in the model, with lines</span></span>
+<span id="cb15-59"><a href="#cb15-59"></a></span>
+<span id="cb15-60"><a href="#cb15-60"></a><span class="in">```{r plot2, dev.args=list(pointsize=6), test = list(plot_v2 = "plot")}</span></span>
+<span id="cb15-61"><a href="#cb15-61"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb15-62"><a href="#cb15-62"></a>  mmrm_results,</span>
+<span id="cb15-63"><a href="#cb15-63"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb15-64"><a href="#cb15-64"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb15-65"><a href="#cb15-65"></a>  <span class="at">show_lines =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-66"><a href="#cb15-66"></a>)</span>
+<span id="cb15-67"><a href="#cb15-67"></a>plot</span>
+<span id="cb15-68"><a href="#cb15-68"></a><span class="in">```</span></span>
+<span id="cb15-69"><a href="#cb15-69"></a></span>
+<span id="cb15-70"><a href="#cb15-70"></a><span class="fu">### Considering the treatment variable in the model, with statistics table</span></span>
+<span id="cb15-71"><a href="#cb15-71"></a></span>
+<span id="cb15-72"><a href="#cb15-72"></a><span class="in">```{r plot3, dev.args=list(pointsize=6), fig.height=7, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb15-73"><a href="#cb15-73"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb15-74"><a href="#cb15-74"></a>  mmrm_results,</span>
+<span id="cb15-75"><a href="#cb15-75"></a>  <span class="at">select =</span> <span class="st">"estimates"</span>,</span>
+<span id="cb15-76"><a href="#cb15-76"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb15-77"><a href="#cb15-77"></a>  <span class="at">table_stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"estimate"</span>, <span class="st">"se"</span>, <span class="st">"ci"</span>),</span>
+<span id="cb15-78"><a href="#cb15-78"></a>  <span class="at">table_font_size =</span> <span class="dv">4</span>,</span>
+<span id="cb15-79"><a href="#cb15-79"></a>  <span class="at">table_rel_height =</span> <span class="fl">0.6</span></span>
+<span id="cb15-80"><a href="#cb15-80"></a>)</span>
+<span id="cb15-81"><a href="#cb15-81"></a>plot</span>
+<span id="cb15-82"><a href="#cb15-82"></a><span class="in">```</span></span>
+<span id="cb15-83"><a href="#cb15-83"></a></span>
+<span id="cb15-84"><a href="#cb15-84"></a><span class="fu">## Least Squares Means: &lt;br/&gt; Contrasts Between Groups</span></span>
+<span id="cb15-85"><a href="#cb15-85"></a></span>
+<span id="cb15-86"><a href="#cb15-86"></a>Users can choose to display both estimates and contrasts together by running <span class="in">`g_mmrm_lsmeans(mmrm_results)`</span>.</span>
+<span id="cb15-87"><a href="#cb15-87"></a></span>
+<span id="cb15-88"><a href="#cb15-88"></a><span class="in">```{r plot4, dev.args=list(pointsize=6), test = list(plot_v4 = "plot")}</span></span>
+<span id="cb15-89"><a href="#cb15-89"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_lsmeans</span>(</span>
+<span id="cb15-90"><a href="#cb15-90"></a>  mmrm_results,</span>
+<span id="cb15-91"><a href="#cb15-91"></a>  <span class="at">select =</span> <span class="st">"contrasts"</span>,</span>
+<span id="cb15-92"><a href="#cb15-92"></a>  <span class="at">titles =</span> <span class="fu">c</span>(<span class="at">contrasts =</span> <span class="st">"Contrasts of FKSI-FWB means"</span>),</span>
+<span id="cb15-93"><a href="#cb15-93"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span></span>
+<span id="cb15-94"><a href="#cb15-94"></a>)</span>
+<span id="cb15-95"><a href="#cb15-95"></a>plot</span>
+<span id="cb15-96"><a href="#cb15-96"></a><span class="in">```</span></span>
+<span id="cb15-97"><a href="#cb15-97"></a></span>
+<span id="cb15-98"><a href="#cb15-98"></a><span class="fu">## Model Diagnostics: Marginal &lt;br/&gt; Fitted Values vs. Residuals</span></span>
+<span id="cb15-99"><a href="#cb15-99"></a></span>
+<span id="cb15-100"><a href="#cb15-100"></a><span class="in">```{r plot5, dev.args=list(pointsize=6), test = list(plot_v5 = "plot")}</span></span>
+<span id="cb15-101"><a href="#cb15-101"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_diagnostic</span>(mmrm_results)</span>
+<span id="cb15-102"><a href="#cb15-102"></a>plot</span>
+<span id="cb15-103"><a href="#cb15-103"></a><span class="in">```</span></span>
+<span id="cb15-104"><a href="#cb15-104"></a></span>
+<span id="cb15-105"><a href="#cb15-105"></a><span class="fu">## Model Diagnostics: Normality &lt;br/&gt; of Marginal Residuals</span></span>
+<span id="cb15-106"><a href="#cb15-106"></a></span>
+<span id="cb15-107"><a href="#cb15-107"></a><span class="in">```{r plot6, dev.args=list(pointsize=6), test = list(plot_v6 = "plot")}</span></span>
+<span id="cb15-108"><a href="#cb15-108"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_mmrm_diagnostic</span>(mmrm_results, <span class="at">type =</span> <span class="st">"q-q-residual"</span>)</span>
+<span id="cb15-109"><a href="#cb15-109"></a>plot</span>
+<span id="cb15-110"><a href="#cb15-110"></a><span class="in">```</span></span>
+<span id="cb15-111"><a href="#cb15-111"></a></span>
+<span id="cb15-112"><a href="#cb15-112"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-113"><a href="#cb15-113"></a></span>
+<span id="cb15-114"><a href="#cb15-114"></a><span class="fu">## `teal` App</span></span>
+<span id="cb15-115"><a href="#cb15-115"></a></span>
+<span id="cb15-116"><a href="#cb15-116"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb15-117"><a href="#cb15-117"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb15-118"><a href="#cb15-118"></a></span>
+<span id="cb15-119"><a href="#cb15-119"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb15-120"><a href="#cb15-120"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-121"><a href="#cb15-121"></a></span>
+<span id="cb15-122"><a href="#cb15-122"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-123"><a href="#cb15-123"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-124"><a href="#cb15-124"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-125"><a href="#cb15-125"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-126"><a href="#cb15-126"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb15-127"><a href="#cb15-127"></a>    <span class="at">AVISIT =</span> <span class="fu">as.factor</span>(AVISIT),</span>
+<span id="cb15-128"><a href="#cb15-128"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb15-129"><a href="#cb15-129"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-130"><a href="#cb15-130"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-131"><a href="#cb15-131"></a>      <span class="fu">as.factor</span>() <span class="co"># making consecutive numeric factor</span></span>
+<span id="cb15-132"><a href="#cb15-132"></a>  )</span>
+<span id="cb15-133"><a href="#cb15-133"></a></span>
+<span id="cb15-134"><a href="#cb15-134"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb15-135"><a href="#cb15-135"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb15-136"><a href="#cb15-136"></a>    <span class="at">ref =</span> <span class="st">"ARM A"</span>,</span>
+<span id="cb15-137"><a href="#cb15-137"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb15-138"><a href="#cb15-138"></a>  )</span>
+<span id="cb15-139"><a href="#cb15-139"></a>)</span>
+<span id="cb15-140"><a href="#cb15-140"></a></span>
+<span id="cb15-141"><a href="#cb15-141"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb15-142"><a href="#cb15-142"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb15-143"><a href="#cb15-143"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb15-144"><a href="#cb15-144"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb15-145"><a href="#cb15-145"></a>    <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb15-146"><a href="#cb15-146"></a><span class="st">    ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb15-147"><a href="#cb15-147"></a><span class="st">    ADQS &lt;- synthetic_cdisc_dataset("latest", "adqs") %&gt;%</span></span>
+<span id="cb15-148"><a href="#cb15-148"></a><span class="st">              dplyr::filter(ABLFL != "Y" &amp; ABLFL2 != "Y") %&gt;%</span></span>
+<span id="cb15-149"><a href="#cb15-149"></a><span class="st">              dplyr::filter(AVISIT %in% c("WEEK 1 DAY 8", "WEEK 2 DAY 15", "WEEK 3 DAY 22")) %&gt;%</span></span>
+<span id="cb15-150"><a href="#cb15-150"></a><span class="st">              dplyr::mutate(</span></span>
+<span id="cb15-151"><a href="#cb15-151"></a><span class="st">                AVISIT = as.factor(AVISIT),</span></span>
+<span id="cb15-152"><a href="#cb15-152"></a><span class="st">                AVISITN = rank(AVISITN) %&gt;%</span></span>
+<span id="cb15-153"><a href="#cb15-153"></a><span class="st">                  as.factor() %&gt;%</span></span>
+<span id="cb15-154"><a href="#cb15-154"></a><span class="st">                  as.numeric() %&gt;%</span></span>
+<span id="cb15-155"><a href="#cb15-155"></a><span class="st">                  as.factor() # making consecutive numeric factor</span></span>
+<span id="cb15-156"><a href="#cb15-156"></a><span class="st">              )</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a><span class="st">    '</span>,</span>
+<span id="cb15-158"><a href="#cb15-158"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-159"><a href="#cb15-159"></a>  ),</span>
+<span id="cb15-160"><a href="#cb15-160"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb15-161"><a href="#cb15-161"></a>    <span class="fu">tm_a_mmrm</span>(</span>
+<span id="cb15-162"><a href="#cb15-162"></a>      <span class="at">label =</span> <span class="st">"MMRM"</span>,</span>
+<span id="cb15-163"><a href="#cb15-163"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb15-164"><a href="#cb15-164"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>), <span class="st">"AVAL"</span>),</span>
+<span id="cb15-165"><a href="#cb15-165"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"SUBJID"</span>), <span class="st">"USUBJID"</span>),</span>
+<span id="cb15-166"><a href="#cb15-166"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARMCD"</span>),</span>
+<span id="cb15-167"><a href="#cb15-167"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"AVISITN"</span>), <span class="st">"AVISIT"</span>),</span>
+<span id="cb15-168"><a href="#cb15-168"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb15-169"><a href="#cb15-169"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-170"><a href="#cb15-170"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb15-171"><a href="#cb15-171"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb15-172"><a href="#cb15-172"></a>      ),</span>
+<span id="cb15-173"><a href="#cb15-173"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"BASE:AVISIT"</span>), <span class="cn">NULL</span>),</span>
+<span id="cb15-174"><a href="#cb15-174"></a>      <span class="at">conf_level =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="fl">0.95</span>, <span class="fl">0.9</span>, <span class="fl">0.8</span>), <span class="fl">0.95</span>)</span>
+<span id="cb15-175"><a href="#cb15-175"></a>    )</span>
+<span id="cb15-176"><a href="#cb15-176"></a>  )</span>
+<span id="cb15-177"><a href="#cb15-177"></a>)</span>
+<span id="cb15-178"><a href="#cb15-178"></a></span>
+<span id="cb15-179"><a href="#cb15-179"></a></span>
+<span id="cb15-180"><a href="#cb15-180"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb15-181"><a href="#cb15-181"></a><span class="in">```</span></span>
+<span id="cb15-182"><a href="#cb15-182"></a></span>
+<span id="cb15-183"><a href="#cb15-183"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-184"><a href="#cb15-184"></a></span>
+<span id="cb15-185"><a href="#cb15-185"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+ <span class="menu-text">PKPG06</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
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+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MMRMG02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Forest Plot for Mixed-Effect Model Repeated Measures</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Comparing Multiple Populations</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mmrmg02_cache/html/setup_a3c74d72b4b69a102a00bdc22bb77219">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">factor</span>(ARMCD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>      <span class="fu">as.factor</span>()</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  )</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a><span class="co"># Simulation of groups.</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a><span class="fu">set.seed</span>(<span class="dv">2</span>)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>adqs_f_with_groups <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">within</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    adqs_f[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adqs_f), <span class="at">size =</span> <span class="dv">1</span> <span class="sc">/</span> <span class="dv">2</span> <span class="sc">*</span> <span class="fu">nrow</span>(adqs_f)), ],</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    group <span class="ot">&lt;-</span> <span class="st">"subpopulation 1"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  ),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">within</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    adqs_f,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    {</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      group <span class="ot">&lt;-</span> <span class="st">"subpopulation 2"</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AVAL <span class="ot">&lt;-</span> AVAL <span class="sc">+</span> <span class="fu">rnorm</span>(<span class="fu">length</span>(AVAL), <span class="at">mean =</span> <span class="dv">10</span>, <span class="at">sd =</span> <span class="dv">2</span>)</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      USUBJID <span class="ot">&lt;-</span> <span class="fu">paste0</span>(USUBJID, <span class="st">"-S2"</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    }</span>
+<span id="cb1-34"><a href="#cb1-34"></a>  )</span>
+<span id="cb1-35"><a href="#cb1-35"></a>)</span>
+<span id="cb1-36"><a href="#cb1-36"></a>adqs_f_with_groups<span class="sc">$</span>group <span class="ot">&lt;-</span> <span class="fu">factor</span>(adqs_f_with_groups<span class="sc">$</span>group)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>For the following part, an MMRM model is fitted for the dataset and from this result forest plots are constructed for each set of subgroups, treatment arm, and visit that is of interest.</p>
+<p>First an MMRM model is fitted for the whole dataset.</p>
+<div class="cell" data-hash="mmrmg02_cache/html/unnamed-chunk-1_bc78928c12040faa5a15df32226030cc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">data =</span> adqs_f_with_groups,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">response =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">cor_struct =</span> <span class="st">"unstructured"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="at">parallel =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Warning: `free_cores()` was deprecated in mmrm 0.1.6.
+ℹ Please use the `omit` argument of `parallelly::availableCores()` instead.
+ℹ The deprecated feature was likely used in the tern.mmrm package.
+  Please report the issue at
+  &lt;https://github.com/insightsengineering/tern.mmrm/issues&gt;.</code></pre>
+</div>
+<div class="cell-output cell-output-stderr">
+<pre><code>Warning: "automatic" optimizer was deprecated in mmrm 0.2.0.
+ℹ please just omit optimizer argument
+ℹ The deprecated feature was likely used in the mmrm package.
+  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.</code></pre>
+</div>
+</div>
+<p>Applying the <code><a href="https://insightsengineering.github.io/tern.mmrm/reference/extract_mmrm_subgroups.html">tern.mmrm::extract_mmrm_subgroups</a></code> function prepares the obtained <code>mmrm_results</code> for a specific visit - in this case we use the <code>SCREENING</code> visit - and treatment arm relative to the reference arm. From these results a table is obtained using the <code><a href="https://insightsengineering.github.io/tern.mmrm/reference/tabulate_mmrm_subgroups.html">tern.mmrm::tabulate_mmrm_subgroups</a></code> function from which the graphic can be directly obtained with <code><a href="https://rdrr.io/pkg/tern/man/g_forest.html">tern::g_forest</a></code>.</p>
+<p>Here we compare <code>ARM A</code> with the reference arm, <code>ARM B</code>.</p>
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="mmrmg02_cache/html/plot1_71ddf54cf95763b11569e0654734c2a4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>df_a <span class="ot">&lt;-</span> <span class="fu">extract_mmrm_subgroups</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">fit =</span> mmrm_results,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">visit =</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"group"</span>, <span class="st">"SEX"</span>),</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="at">treatment_arm =</span> <span class="st">"ARM A"</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>)</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>tab_a <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="fu">tabulate_mmrm_subgroups</span>(</span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="at">df =</span> df_a,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"diff"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>)</span>
+<span id="cb5-12"><a href="#cb5-12"></a>  )</span>
+<span id="cb5-13"><a href="#cb5-13"></a></span>
+<span id="cb5-14"><a href="#cb5-14"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb5-15"><a href="#cb5-15"></a>  tab_a,</span>
+<span id="cb5-16"><a href="#cb5-16"></a>  <span class="at">logx =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb5-17"><a href="#cb5-17"></a>  <span class="at">xlim =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="fl">2.5</span>),</span>
+<span id="cb5-18"><a href="#cb5-18"></a>  <span class="at">x_at =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="sc">-</span><span class="fl">2.5</span>, <span class="dv">0</span>, <span class="fl">2.5</span>),</span>
+<span id="cb5-19"><a href="#cb5-19"></a>  <span class="at">vline =</span> <span class="dv">0</span></span>
+<span id="cb5-20"><a href="#cb5-20"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg02_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.11] </code></pre>
+</div>
+</div>
+<p>Then we compare <code>ARM C</code> with <code>ARM B</code>.</p>
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="mmrmg02_cache/html/plot2_74603b62e908528616bfabed62ff4206">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>df_c <span class="ot">&lt;-</span> <span class="fu">extract_mmrm_subgroups</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="at">fit =</span> mmrm_results,</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">visit =</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"group"</span>, <span class="st">"SEX"</span>),</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">treatment_arm =</span> <span class="st">"ARM C"</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>)</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>tab_c <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">tabulate_mmrm_subgroups</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">df =</span> df_c,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"diff"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>)</span>
+<span id="cb8-12"><a href="#cb8-12"></a>  )</span>
+<span id="cb8-13"><a href="#cb8-13"></a></span>
+<span id="cb8-14"><a href="#cb8-14"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  tab_c,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="at">logx =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>  <span class="at">xlim =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="fl">2.5</span>),</span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="at">x_at =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="sc">-</span><span class="fl">2.5</span>, <span class="dv">0</span>, <span class="fl">2.5</span>),</span>
+<span id="cb8-19"><a href="#cb8-19"></a>  <span class="at">vline =</span> <span class="dv">0</span></span>
+<span id="cb8-20"><a href="#cb8-20"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmg02_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.40] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mmrmg02_cache/html/sessioninfo_b8516ee0e713f90a233cb8337bea2ff0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  tern.mmrm_0.2.1  tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] gtable_0.3.4        TMB_1.9.6           xfun_0.40          
+ [4] ggplot2_3.4.3       htmlwidgets_1.6.2   lattice_0.21-8     
+ [7] numDeriv_2016.8-1.1 vctrs_0.6.3         tools_4.3.1        
+[10] Rdpack_2.5          generics_0.1.3      parallel_4.3.1     
+[13] sandwich_3.0-2      tibble_3.2.1        mmrm_0.2.2         
+[16] fansi_1.0.4         pkgconfig_2.0.3     Matrix_1.6-1.1     
+[19] checkmate_2.2.0     lifecycle_1.0.3     compiler_4.3.1     
+[22] stringr_1.5.0       brio_1.1.3          munsell_0.5.0      
+[25] codetools_0.2-19    htmltools_0.5.6     yaml_2.3.7         
+[28] pillar_1.9.0        tidyr_1.3.0         MASS_7.3-60        
+[31] multcomp_1.4-25     nlme_3.1-163        tidyselect_1.2.0   
+[34] digest_0.6.33       mvtnorm_1.2-3       stringi_1.7.12     
+[37] purrr_1.0.2         splines_4.3.1       cowplot_1.1.1      
+[40] fastmap_1.1.1       grid_4.3.1          colorspace_2.1-0   
+[43] cli_3.6.1           survival_3.5-7      utf8_1.2.3         
+[46] broom_1.0.5         TH.data_1.1-2       scales_1.2.1       
+[49] backports_1.4.1     estimability_1.4.1  rmarkdown_2.25     
+[52] emmeans_1.8.8       zoo_1.8-12          coda_0.19-4        
+[55] evaluate_0.21       knitr_1.44          rbibutils_2.2.15   
+[58] testthat_3.1.10     rlang_1.1.1         Rcpp_1.0.11        
+[61] xtable_1.8-4        glue_1.6.2          rstudioapi_0.15.0  
+[64] jsonlite_1.8.7      R6_2.5.1           </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mmrmg02_cache/html/snapshot_6b1df18ff493a3e8673f44ca1eb6f29d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/efficacy/mmrmg02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
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+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/efficacy/mmrmg01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">MMRMG01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/other/brg01.html" class="pagination-link">
+        <span class="nav-page-text">BRG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> MMRMG02</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Forest Plot for Mixed-Effect Model Repeated Measures</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb14-20"><a href="#cb14-20"></a></span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb14-23"><a href="#cb14-23"></a></span>
+<span id="cb14-24"><a href="#cb14-24"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-26"><a href="#cb14-26"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-27"><a href="#cb14-27"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">factor</span>(ARMCD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb14-28"><a href="#cb14-28"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb14-29"><a href="#cb14-29"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-31"><a href="#cb14-31"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-32"><a href="#cb14-32"></a>      <span class="fu">as.factor</span>()</span>
+<span id="cb14-33"><a href="#cb14-33"></a>  )</span>
+<span id="cb14-34"><a href="#cb14-34"></a></span>
+<span id="cb14-35"><a href="#cb14-35"></a><span class="co"># Simulation of groups.</span></span>
+<span id="cb14-36"><a href="#cb14-36"></a><span class="fu">set.seed</span>(<span class="dv">2</span>)</span>
+<span id="cb14-37"><a href="#cb14-37"></a>adqs_f_with_groups <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb14-38"><a href="#cb14-38"></a>  <span class="fu">within</span>(</span>
+<span id="cb14-39"><a href="#cb14-39"></a>    adqs_f[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adqs_f), <span class="at">size =</span> <span class="dv">1</span> <span class="sc">/</span> <span class="dv">2</span> <span class="sc">*</span> <span class="fu">nrow</span>(adqs_f)), ],</span>
+<span id="cb14-40"><a href="#cb14-40"></a>    group <span class="ot">&lt;-</span> <span class="st">"subpopulation 1"</span></span>
+<span id="cb14-41"><a href="#cb14-41"></a>  ),</span>
+<span id="cb14-42"><a href="#cb14-42"></a>  <span class="fu">within</span>(</span>
+<span id="cb14-43"><a href="#cb14-43"></a>    adqs_f,</span>
+<span id="cb14-44"><a href="#cb14-44"></a>    {</span>
+<span id="cb14-45"><a href="#cb14-45"></a>      group <span class="ot">&lt;-</span> <span class="st">"subpopulation 2"</span></span>
+<span id="cb14-46"><a href="#cb14-46"></a>      AVAL <span class="ot">&lt;-</span> AVAL <span class="sc">+</span> <span class="fu">rnorm</span>(<span class="fu">length</span>(AVAL), <span class="at">mean =</span> <span class="dv">10</span>, <span class="at">sd =</span> <span class="dv">2</span>)</span>
+<span id="cb14-47"><a href="#cb14-47"></a>      USUBJID <span class="ot">&lt;-</span> <span class="fu">paste0</span>(USUBJID, <span class="st">"-S2"</span>)</span>
+<span id="cb14-48"><a href="#cb14-48"></a>    }</span>
+<span id="cb14-49"><a href="#cb14-49"></a>  )</span>
+<span id="cb14-50"><a href="#cb14-50"></a>)</span>
+<span id="cb14-51"><a href="#cb14-51"></a>adqs_f_with_groups<span class="sc">$</span>group <span class="ot">&lt;-</span> <span class="fu">factor</span>(adqs_f_with_groups<span class="sc">$</span>group)</span>
+<span id="cb14-52"><a href="#cb14-52"></a><span class="in">```</span></span>
+<span id="cb14-53"><a href="#cb14-53"></a></span>
+<span id="cb14-54"><a href="#cb14-54"></a><span class="fu">## Comparing Multiple Populations</span></span>
+<span id="cb14-55"><a href="#cb14-55"></a></span>
+<span id="cb14-56"><a href="#cb14-56"></a>For the following part, an MMRM model is fitted for the dataset and from this result forest plots are constructed for each set of subgroups, treatment arm, and visit that is of interest.</span>
+<span id="cb14-57"><a href="#cb14-57"></a></span>
+<span id="cb14-58"><a href="#cb14-58"></a>First an MMRM model is fitted for the whole dataset.</span>
+<span id="cb14-59"><a href="#cb14-59"></a></span>
+<span id="cb14-62"><a href="#cb14-62"></a><span class="in">```{r}</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a></span>
+<span id="cb14-65"><a href="#cb14-65"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb14-66"><a href="#cb14-66"></a>  <span class="at">data =</span> adqs_f_with_groups,</span>
+<span id="cb14-67"><a href="#cb14-67"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb14-68"><a href="#cb14-68"></a>    <span class="at">response =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(),</span>
+<span id="cb14-70"><a href="#cb14-70"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-71"><a href="#cb14-71"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb14-72"><a href="#cb14-72"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb14-73"><a href="#cb14-73"></a>  ),</span>
+<span id="cb14-74"><a href="#cb14-74"></a>  <span class="at">cor_struct =</span> <span class="st">"unstructured"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb14-76"><a href="#cb14-76"></a>  <span class="at">parallel =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>)</span>
+<span id="cb14-78"><a href="#cb14-78"></a><span class="in">```</span></span>
+<span id="cb14-79"><a href="#cb14-79"></a></span>
+<span id="cb14-80"><a href="#cb14-80"></a>Applying the <span class="in">`tern.mmrm::extract_mmrm_subgroups`</span> function prepares the obtained <span class="in">`mmrm_results`</span> for a specific visit - in this case we use the <span class="in">`SCREENING`</span> visit - and treatment arm relative to the reference arm.</span>
+<span id="cb14-81"><a href="#cb14-81"></a>From these results a table is obtained using the <span class="in">`tern.mmrm::tabulate_mmrm_subgroups`</span> function from which the graphic can be directly obtained with <span class="in">`tern::g_forest`</span>.</span>
+<span id="cb14-82"><a href="#cb14-82"></a></span>
+<span id="cb14-83"><a href="#cb14-83"></a>Here we compare <span class="in">`ARM A`</span> with the reference arm, <span class="in">`ARM B`</span>.</span>
+<span id="cb14-84"><a href="#cb14-84"></a></span>
+<span id="cb14-85"><a href="#cb14-85"></a><span class="in">```{r plot1, warning=FALSE, fig.width = 15, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb14-86"><a href="#cb14-86"></a>df_a <span class="ot">&lt;-</span> <span class="fu">extract_mmrm_subgroups</span>(</span>
+<span id="cb14-87"><a href="#cb14-87"></a>  <span class="at">fit =</span> mmrm_results,</span>
+<span id="cb14-88"><a href="#cb14-88"></a>  <span class="at">visit =</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb14-89"><a href="#cb14-89"></a>  <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"group"</span>, <span class="st">"SEX"</span>),</span>
+<span id="cb14-90"><a href="#cb14-90"></a>  <span class="at">treatment_arm =</span> <span class="st">"ARM A"</span></span>
+<span id="cb14-91"><a href="#cb14-91"></a>)</span>
+<span id="cb14-92"><a href="#cb14-92"></a></span>
+<span id="cb14-93"><a href="#cb14-93"></a>tab_a <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-94"><a href="#cb14-94"></a>  <span class="fu">tabulate_mmrm_subgroups</span>(</span>
+<span id="cb14-95"><a href="#cb14-95"></a>    <span class="at">df =</span> df_a,</span>
+<span id="cb14-96"><a href="#cb14-96"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"diff"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>)</span>
+<span id="cb14-97"><a href="#cb14-97"></a>  )</span>
+<span id="cb14-98"><a href="#cb14-98"></a></span>
+<span id="cb14-99"><a href="#cb14-99"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb14-100"><a href="#cb14-100"></a>  tab_a,</span>
+<span id="cb14-101"><a href="#cb14-101"></a>  <span class="at">logx =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-102"><a href="#cb14-102"></a>  <span class="at">xlim =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="fl">2.5</span>),</span>
+<span id="cb14-103"><a href="#cb14-103"></a>  <span class="at">x_at =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="sc">-</span><span class="fl">2.5</span>, <span class="dv">0</span>, <span class="fl">2.5</span>),</span>
+<span id="cb14-104"><a href="#cb14-104"></a>  <span class="at">vline =</span> <span class="dv">0</span></span>
+<span id="cb14-105"><a href="#cb14-105"></a>)</span>
+<span id="cb14-106"><a href="#cb14-106"></a>plot</span>
+<span id="cb14-107"><a href="#cb14-107"></a><span class="in">```</span></span>
+<span id="cb14-108"><a href="#cb14-108"></a></span>
+<span id="cb14-109"><a href="#cb14-109"></a>Then we compare <span class="in">`ARM C`</span> with <span class="in">`ARM B`</span>.</span>
+<span id="cb14-110"><a href="#cb14-110"></a></span>
+<span id="cb14-111"><a href="#cb14-111"></a><span class="in">```{r plot2, warning=FALSE, fig.width = 15, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb14-112"><a href="#cb14-112"></a>df_c <span class="ot">&lt;-</span> <span class="fu">extract_mmrm_subgroups</span>(</span>
+<span id="cb14-113"><a href="#cb14-113"></a>  <span class="at">fit =</span> mmrm_results,</span>
+<span id="cb14-114"><a href="#cb14-114"></a>  <span class="at">visit =</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb14-115"><a href="#cb14-115"></a>  <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"group"</span>, <span class="st">"SEX"</span>),</span>
+<span id="cb14-116"><a href="#cb14-116"></a>  <span class="at">treatment_arm =</span> <span class="st">"ARM C"</span></span>
+<span id="cb14-117"><a href="#cb14-117"></a>)</span>
+<span id="cb14-118"><a href="#cb14-118"></a></span>
+<span id="cb14-119"><a href="#cb14-119"></a>tab_c <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-120"><a href="#cb14-120"></a>  <span class="fu">tabulate_mmrm_subgroups</span>(</span>
+<span id="cb14-121"><a href="#cb14-121"></a>    <span class="at">df =</span> df_c,</span>
+<span id="cb14-122"><a href="#cb14-122"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"diff"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>)</span>
+<span id="cb14-123"><a href="#cb14-123"></a>  )</span>
+<span id="cb14-124"><a href="#cb14-124"></a></span>
+<span id="cb14-125"><a href="#cb14-125"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_forest</span>(</span>
+<span id="cb14-126"><a href="#cb14-126"></a>  tab_c,</span>
+<span id="cb14-127"><a href="#cb14-127"></a>  <span class="at">logx =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-128"><a href="#cb14-128"></a>  <span class="at">xlim =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="fl">2.5</span>),</span>
+<span id="cb14-129"><a href="#cb14-129"></a>  <span class="at">x_at =</span> <span class="fu">c</span>(<span class="sc">-</span><span class="dv">5</span>, <span class="sc">-</span><span class="fl">2.5</span>, <span class="dv">0</span>, <span class="fl">2.5</span>),</span>
+<span id="cb14-130"><a href="#cb14-130"></a>  <span class="at">vline =</span> <span class="dv">0</span></span>
+<span id="cb14-131"><a href="#cb14-131"></a>)</span>
+<span id="cb14-132"><a href="#cb14-132"></a>plot</span>
+<span id="cb14-133"><a href="#cb14-133"></a><span class="in">```</span></span>
+<span id="cb14-134"><a href="#cb14-134"></a></span>
+<span id="cb14-135"><a href="#cb14-135"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-136"><a href="#cb14-136"></a></span>
+<span id="cb14-137"><a href="#cb14-137"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-138"><a href="#cb14-138"></a></span>
+<span id="cb14-139"><a href="#cb14-139"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - BRG01">
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+  <li class="nav-item compact">
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+  </li>  
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
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+<div class="quarto-navbar-tools">
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+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">BRG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Bar Chart</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of Frequency</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot of Percentage</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot of Frequency with <br> Total Number of Subjects</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot of Frequency <br> with Horizontal Bars</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Plot of Percentage <br> and Confidence Intervals</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Plot of Percentage by <br> Treatment and Covariate</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Plot of Percentage by <br> Covariate and Treatment</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Plot of Percentage <br> with Mean and Median</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false">Plot of Categorical <br> Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-12-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-12" role="tab" aria-controls="tabset-1-12" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="brg01_cache/html/setup_42a5fce709be36fbcd1e5b5def7d5d64">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(binom)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># filtered population</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>patpop_df <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">group_by</span>(STUDYID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">summarise</span>(<span class="at">patpop =</span> <span class="fu">n</span>())</span>
+<span id="cb1-15"><a href="#cb1-15"></a>patpop <span class="ot">&lt;-</span> <span class="fu">setNames</span>(patpop_df<span class="sc">$</span>patpop, patpop_df<span class="sc">$</span>STUDYID)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>denom <span class="ot">&lt;-</span> patpop_df<span class="sc">$</span>patpop</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">mutate</span>(<span class="at">AETOXGRC =</span> <span class="fu">as.character</span>(AETOXGR))</span>
+<span id="cb1-20"><a href="#cb1-20"></a><span class="fu">attributes</span>(adae<span class="sc">$</span>AETOXGRC)<span class="sc">$</span>label <span class="ot">&lt;-</span> <span class="st">"Analysis Toxicity Grade (C)"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>vl_ae <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>vl_lb <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot1_927b2d08667ac1a7a566f8ba4fa60df7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb2-4"><a href="#cb2-4"></a></span>
+<span id="cb2-5"><a href="#cb2-5"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">geom_text</span>(<span class="at">stat =</span> <span class="st">"count"</span>, <span class="fu">aes</span>(<span class="at">label =</span> ggplot2<span class="sc">::</span><span class="fu">after_stat</span>(count)), <span class="at">vjust =</span> <span class="sc">-</span>.<span class="dv">5</span>) <span class="sc">+</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot2_3c2ba4640b1ae0624417234e6fba8df7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(AESOC <span class="sc">==</span> <span class="st">"cl A"</span>)</span>
+<span id="cb3-3"><a href="#cb3-3"></a></span>
+<span id="cb3-4"><a href="#cb3-4"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb3-8"><a href="#cb3-8"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-9"><a href="#cb3-9"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb3-10"><a href="#cb3-10"></a></span>
+<span id="cb3-11"><a href="#cb3-11"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> pct), <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb3-13"><a href="#cb3-13"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb3-14"><a href="#cb3-14"></a>  <span class="fu">geom_text</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct, <span class="at">label =</span> pct), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">vjust =</span> <span class="sc">-</span><span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb3-15"><a href="#cb3-15"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb3-16"><a href="#cb3-16"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb3-18"><a href="#cb3-18"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb3-19"><a href="#cb3-19"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot3_4ebd2862e2fdc2cb8a5602f65f0f4475">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">filter</span>(AESOC <span class="sc">==</span> <span class="st">"cl A"</span>)</span>
+<span id="cb4-3"><a href="#cb4-3"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">mutate</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">mutate</span>(<span class="at">xvarlabel =</span> <span class="fu">paste0</span>(ACTARM, <span class="st">"</span><span class="sc">\n\n</span><span class="st">N = "</span>, n))</span>
+<span id="cb4-9"><a href="#cb4-9"></a></span>
+<span id="cb4-10"><a href="#cb4-10"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"xvarlabel"</span>]])) <span class="sc">+</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>)</span>
+<span id="cb4-16"><a href="#cb4-16"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot4_5b86284ce5d8f30f1ffc3e8f3e7c5ff2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb5-3"><a href="#cb5-3"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb5-4"><a href="#cb5-4"></a></span>
+<span id="cb5-5"><a href="#cb5-5"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb5-8"><a href="#cb5-8"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>) <span class="sc">+</span></span>
+<span id="cb5-11"><a href="#cb5-11"></a>  <span class="fu">coord_flip</span>()</span>
+<span id="cb5-12"><a href="#cb5-12"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot5_f0ad8f49187c777d7e3056640f883f35">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>anl <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span> ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span>)</span>
+<span id="cb6-3"><a href="#cb6-3"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>patpop5 <span class="ot">&lt;-</span> <span class="fu">as.data.frame</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">mutate</span>(<span class="at">ACTARM =</span> <span class="fu">as.vector</span>(Var1)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">mutate</span>(<span class="at">TRTPOP =</span> Freq) <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">select</span>(ACTARM, TRTPOP)</span>
+<span id="cb6-9"><a href="#cb6-9"></a></span>
+<span id="cb6-10"><a href="#cb6-10"></a>anlpop <span class="ot">&lt;-</span> <span class="fu">as.data.frame</span>(<span class="fu">table</span>(anl<span class="sc">$</span>ANRIND, anl<span class="sc">$</span>ACTARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">filter</span>(Var1 <span class="sc">==</span> <span class="st">"HIGH"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">mutate</span>(<span class="at">ACTARM =</span> <span class="fu">as.vector</span>(Var2)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="fu">mutate</span>(<span class="at">EVENTCOUNT =</span> Freq) <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">select</span>(ACTARM, EVENTCOUNT)</span>
+<span id="cb6-15"><a href="#cb6-15"></a></span>
+<span id="cb6-16"><a href="#cb6-16"></a>anl <span class="ot">&lt;-</span> <span class="fu">left_join</span>(patpop5, anlpop, <span class="at">by =</span> <span class="st">"ACTARM"</span>)</span>
+<span id="cb6-17"><a href="#cb6-17"></a>CIs <span class="ot">&lt;-</span> <span class="fu">binom.confint</span>(<span class="at">x =</span> anl<span class="sc">$</span>EVENTCOUNT, <span class="at">n =</span> anl<span class="sc">$</span>TRTPOP, <span class="at">methods =</span> <span class="st">"exact"</span>)</span>
+<span id="cb6-18"><a href="#cb6-18"></a>anl <span class="ot">&lt;-</span> <span class="fu">cbind</span>(anl, CIs[, <span class="dv">4</span><span class="sc">:</span><span class="dv">6</span>])</span>
+<span id="cb6-19"><a href="#cb6-19"></a></span>
+<span id="cb6-20"><a href="#cb6-20"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl) <span class="sc">+</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="fu">geom_bar</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> mean <span class="sc">*</span> <span class="dv">100</span>), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>], <span class="at">alpha =</span> <span class="fl">0.7</span>) <span class="sc">+</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">geom_errorbar</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">ymin =</span> lower <span class="sc">*</span> <span class="dv">100</span>, <span class="at">ymax =</span> upper <span class="sc">*</span> <span class="dv">100</span>),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">width =</span> <span class="fl">0.5</span>, <span class="at">colour =</span> <span class="st">"#20b4ff"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">alpha =</span> <span class="fl">0.9</span>, <span class="at">linewidth =</span> <span class="fl">1.0</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>  <span class="fu">ylab</span>(<span class="st">"Percentage"</span>)</span>
+<span id="cb6-30"><a href="#cb6-30"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot5-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;plot_v6&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot6_6a9016d37f70a8b28c7d1de83f36a908">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb7-3"><a href="#cb7-3"></a></span>
+<span id="cb7-4"><a href="#cb7-4"></a>patpop6 <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">count</span>(adsl, ACTARM, SEX, <span class="at">name =</span> <span class="st">"N_arm_sex"</span>)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb7-7"><a href="#cb7-7"></a>  <span class="fu">group_by</span>(ACTARM, SEX) <span class="sc">%&gt;%</span></span>
+<span id="cb7-8"><a href="#cb7-8"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">left_join</span>(patpop6, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"ACTARM"</span>, <span class="st">"SEX"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-10"><a href="#cb7-10"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N_arm_sex) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb7-11"><a href="#cb7-11"></a></span>
+<span id="cb7-12"><a href="#cb7-12"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]], <span class="at">fill =</span> .data[[<span class="st">"SEX"</span>]])) <span class="sc">+</span></span>
+<span id="cb7-13"><a href="#cb7-13"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct), <span class="at">position =</span> <span class="fu">position_dodge</span>()) <span class="sc">+</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"SEX"</span>))) <span class="sc">+</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb7-16"><a href="#cb7-16"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb7-17"><a href="#cb7-17"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb7-18"><a href="#cb7-18"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb7-19"><a href="#cb7-19"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb7-20"><a href="#cb7-20"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot6-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-test="{&quot;plot_v7&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot7_c122e7af9f57fdcd294cfb4e2fdccb09">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">group_by</span>(SEX, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb8-10"><a href="#cb8-10"></a></span>
+<span id="cb8-11"><a href="#cb8-11"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"SEX"</span>]], <span class="at">fill =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct), <span class="at">position =</span> <span class="fu">position_dodge</span>()) <span class="sc">+</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>))) <span class="sc">+</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"SEX"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb8-19"><a href="#cb8-19"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot7-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<div class="cell" data-test="{&quot;plot_v8&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot8_7fcee31e1ffec91b8f0dc0c9958afa1c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>anl1 <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>, PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">&amp;</span> ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span>)</span>
+<span id="cb9-3"><a href="#cb9-3"></a></span>
+<span id="cb9-4"><a href="#cb9-4"></a>anl <span class="ot">&lt;-</span> anl1[<span class="sc">!</span><span class="fu">duplicated</span>(anl1<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb9-6"><a href="#cb9-6"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb9-7"><a href="#cb9-7"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb9-8"><a href="#cb9-8"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb9-10"><a href="#cb9-10"></a></span>
+<span id="cb9-11"><a href="#cb9-11"></a>graph <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> pct), <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma, <span class="at">expand =</span> <span class="fu">expansion</span>(<span class="fu">c</span>(<span class="dv">0</span>, .<span class="dv">25</span>))) <span class="sc">+</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a>  <span class="fu">geom_text</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct, <span class="at">label =</span> pct), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">vjust =</span> <span class="sc">-</span><span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb9-16"><a href="#cb9-16"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects with Abnormaly High CRP at Baseline </span><span class="sc">\n</span><span class="st"> Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb9-17"><a href="#cb9-17"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_lb, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb9-18"><a href="#cb9-18"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>sd_w <span class="ot">&lt;-</span> anl1 <span class="sc">%&gt;%</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb9-22"><a href="#cb9-22"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb9-23"><a href="#cb9-23"></a>    <span class="at">mean =</span> <span class="fu">round</span>(<span class="fu">mean</span>(AVAL, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="dv">2</span>),</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    <span class="at">median =</span> <span class="fu">round</span>(<span class="fu">median</span>(AVAL, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="dv">2</span>)</span>
+<span id="cb9-25"><a href="#cb9-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-26"><a href="#cb9-26"></a>  <span class="fu">arrange</span>(ACTARM)</span>
+<span id="cb9-27"><a href="#cb9-27"></a></span>
+<span id="cb9-28"><a href="#cb9-28"></a>sd_l <span class="ot">&lt;-</span> <span class="fu">gather</span>(sd_w, <span class="at">key =</span> stat, <span class="at">value =</span> value, mean<span class="sc">:</span>median)</span>
+<span id="cb9-29"><a href="#cb9-29"></a>sd_l <span class="ot">&lt;-</span> sd_l <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="at">stat_lbl =</span> <span class="fu">case_when</span>(</span>
+<span id="cb9-31"><a href="#cb9-31"></a>    stat <span class="sc">==</span> <span class="st">"mean"</span> <span class="sc">~</span> <span class="st">"Mean"</span>,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    stat <span class="sc">==</span> <span class="st">"median"</span> <span class="sc">~</span> <span class="st">"Median"</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a>  )</span>
+<span id="cb9-34"><a href="#cb9-34"></a>)</span>
+<span id="cb9-35"><a href="#cb9-35"></a></span>
+<span id="cb9-36"><a href="#cb9-36"></a>sd_l<span class="sc">$</span>stat_lbl <span class="ot">&lt;-</span> <span class="fu">factor</span>(sd_l<span class="sc">$</span>stat_lbl, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Median"</span>, <span class="st">"Mean"</span>))</span>
+<span id="cb9-37"><a href="#cb9-37"></a></span>
+<span id="cb9-38"><a href="#cb9-38"></a>tbl_theme <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">panel.border =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">panel.grid.major =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">panel.grid.minor =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">axis.ticks =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="at">axis.text.y =</span> <span class="fu">element_text</span>(<span class="at">face =</span> <span class="st">"plain"</span>),</span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb9-46"><a href="#cb9-46"></a>)</span>
+<span id="cb9-47"><a href="#cb9-47"></a></span>
+<span id="cb9-48"><a href="#cb9-48"></a>tbl <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(sd_l, <span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> stat_lbl, <span class="at">label =</span> value)) <span class="sc">+</span></span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="fu">levels</span>(sd_l<span class="sc">$</span>stat_lbl)) <span class="sc">+</span></span>
+<span id="cb9-51"><a href="#cb9-51"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb9-52"><a href="#cb9-52"></a>  tbl_theme</span>
+<span id="cb9-53"><a href="#cb9-53"></a></span>
+<span id="cb9-54"><a href="#cb9-54"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(graph, tbl,</span>
+<span id="cb9-55"><a href="#cb9-55"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">4</span>, <span class="dv">1</span>),</span>
+<span id="cb9-56"><a href="#cb9-56"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb9-57"><a href="#cb9-57"></a>)</span>
+<span id="cb9-58"><a href="#cb9-58"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot8-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-test="{&quot;plot_v9&quot;:&quot;plot&quot;}" data-hash="brg01_cache/html/plot9_6dc2f861f342f231003f30f38d0e8c7b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>anl <span class="ot">&lt;-</span> adae</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>  <span class="fu">arrange</span>(USUBJID, AETOXGRC) <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">group_by</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-6"><a href="#cb10-6"></a>  <span class="fu">slice</span>(<span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb10-8"><a href="#cb10-8"></a></span>
+<span id="cb10-9"><a href="#cb10-9"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>  <span class="fu">group_by</span>(ACTARM, AETOXGRC) <span class="sc">%&gt;%</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb10-13"><a href="#cb10-13"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]], <span class="at">fill =</span> .data[[<span class="st">"AETOXGRC"</span>]])) <span class="sc">+</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct)) <span class="sc">+</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"AETOXGRC"</span>))) <span class="sc">+</span></span>
+<span id="cb10-19"><a href="#cb10-19"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb10-20"><a href="#cb10-20"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb10-21"><a href="#cb10-21"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With AE by Highest </span><span class="sc">\n</span><span class="st"> NCI CTCAE Grade: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb10-24"><a href="#cb10-24"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="brg01_files/figure-html/plot9-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="brg01_cache/html/teal_bdccca2f573193a47b24a60e74e9adce">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-12" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-12-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="brg01_cache/html/sessioninfo_e5b5868b74067003fc25054c50e0dbcf">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] nestcolor_0.1.2  tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+ [5] formatters_0.5.2 tidyr_1.3.0      scda_0.1.6       ggplot2_3.4.3   
+ [9] dplyr_1.1.3      binom_1.1-1.1   
+
+loaded via a namespace (and not attached):
+ [1] utf8_1.2.3        generics_0.1.3    rstatix_0.7.2     lattice_0.21-8   
+ [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    
+ [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       
+[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     
+[17] codetools_0.2-19  abind_1.4-5       Rdpack_2.5        cli_3.6.1        
+[21] rlang_1.1.1       rbibutils_2.2.15  cowplot_1.1.1     munsell_0.5.0    
+[25] splines_4.3.1     withr_2.5.0       yaml_2.3.7        tools_4.3.1      
+[29] ggsignif_0.6.4    checkmate_2.2.0   colorspace_2.1-0  ggpubr_0.6.0     
+[33] broom_1.0.5       vctrs_0.6.3       R6_2.5.1          lifecycle_1.0.3  
+[37] car_3.1-2         htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     
+[41] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     
+[45] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     
+[49] htmltools_0.5.6   carData_3.0-5     rmarkdown_2.25    labeling_0.4.3   
+[53] testthat_3.1.10   compiler_4.3.1   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="brg01_cache/html/snapshot_f67b1a1ca9a2b555fe161fd293efdbc9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/brg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
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+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
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+      const stylesheet = stylesheets[i];
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+  const enableStylesheet = (stylesheets) => {
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+      stylesheet.rel = 'stylesheet';
+    }
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+  const manageTransitions = (selector, allowTransitions) => {
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+  const toggleColorMode = (alternate) => {
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+        if (sheetNode.id === "quarto-bootstrap") {
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+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
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+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
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+  // Ensure there is a toggle, if there isn't float one in the top right
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+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
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+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
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+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
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+        button.removeAttribute("data-bs-title");
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+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
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+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
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+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
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+  if (showAllCode) {
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+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
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+      const id = href.replace(/^#\/?/, "");
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+          }
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+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
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+            clickedEl.classList.add('code-annotation-active');
+          } else {
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+            clickedEl.classList.remove('code-annotation-active');
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+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
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+        };
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/efficacy/mmrmg02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">MMRMG02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/other/bwg01.html" class="pagination-link">
+        <span class="nav-page-text">BWG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> BRG01</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Bar Chart</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>::: panel-tabset</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-14"><a href="#cb15-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a></span>
+<span id="cb15-16"><a href="#cb15-16"></a><span class="fu">library</span>(binom)</span>
+<span id="cb15-17"><a href="#cb15-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-18"><a href="#cb15-18"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb15-19"><a href="#cb15-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-20"><a href="#cb15-20"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb15-21"><a href="#cb15-21"></a><span class="fu">library</span>(tern)</span>
+<span id="cb15-22"><a href="#cb15-22"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb15-23"><a href="#cb15-23"></a></span>
+<span id="cb15-24"><a href="#cb15-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-25"><a href="#cb15-25"></a></span>
+<span id="cb15-26"><a href="#cb15-26"></a><span class="co"># filtered population</span></span>
+<span id="cb15-27"><a href="#cb15-27"></a>patpop_df <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb15-28"><a href="#cb15-28"></a>  <span class="fu">group_by</span>(STUDYID) <span class="sc">%&gt;%</span></span>
+<span id="cb15-29"><a href="#cb15-29"></a>  <span class="fu">summarise</span>(<span class="at">patpop =</span> <span class="fu">n</span>())</span>
+<span id="cb15-30"><a href="#cb15-30"></a>patpop <span class="ot">&lt;-</span> <span class="fu">setNames</span>(patpop_df<span class="sc">$</span>patpop, patpop_df<span class="sc">$</span>STUDYID)</span>
+<span id="cb15-31"><a href="#cb15-31"></a>denom <span class="ot">&lt;-</span> patpop_df<span class="sc">$</span>patpop</span>
+<span id="cb15-32"><a href="#cb15-32"></a></span>
+<span id="cb15-33"><a href="#cb15-33"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-34"><a href="#cb15-34"></a>  <span class="fu">mutate</span>(<span class="at">AETOXGRC =</span> <span class="fu">as.character</span>(AETOXGR))</span>
+<span id="cb15-35"><a href="#cb15-35"></a><span class="fu">attributes</span>(adae<span class="sc">$</span>AETOXGRC)<span class="sc">$</span>label <span class="ot">&lt;-</span> <span class="st">"Analysis Toxicity Grade (C)"</span></span>
+<span id="cb15-36"><a href="#cb15-36"></a>vl_ae <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb15-37"><a href="#cb15-37"></a></span>
+<span id="cb15-38"><a href="#cb15-38"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb15-39"><a href="#cb15-39"></a>vl_lb <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb15-40"><a href="#cb15-40"></a><span class="in">```</span></span>
+<span id="cb15-41"><a href="#cb15-41"></a></span>
+<span id="cb15-42"><a href="#cb15-42"></a><span class="fu">## Plot of Frequency</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a></span>
+<span id="cb15-44"><a href="#cb15-44"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb15-45"><a href="#cb15-45"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-46"><a href="#cb15-46"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb15-47"><a href="#cb15-47"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb15-48"><a href="#cb15-48"></a></span>
+<span id="cb15-49"><a href="#cb15-49"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-50"><a href="#cb15-50"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb15-51"><a href="#cb15-51"></a>  <span class="fu">geom_text</span>(<span class="at">stat =</span> <span class="st">"count"</span>, <span class="fu">aes</span>(<span class="at">label =</span> ggplot2<span class="sc">::</span><span class="fu">after_stat</span>(count)), <span class="at">vjust =</span> <span class="sc">-</span>.<span class="dv">5</span>) <span class="sc">+</span></span>
+<span id="cb15-52"><a href="#cb15-52"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-53"><a href="#cb15-53"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-54"><a href="#cb15-54"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-55"><a href="#cb15-55"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>)</span>
+<span id="cb15-56"><a href="#cb15-56"></a>plot</span>
+<span id="cb15-57"><a href="#cb15-57"></a><span class="in">```</span></span>
+<span id="cb15-58"><a href="#cb15-58"></a></span>
+<span id="cb15-59"><a href="#cb15-59"></a><span class="fu">## Plot of Percentage</span></span>
+<span id="cb15-60"><a href="#cb15-60"></a></span>
+<span id="cb15-61"><a href="#cb15-61"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb15-62"><a href="#cb15-62"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-63"><a href="#cb15-63"></a>  <span class="fu">filter</span>(AESOC <span class="sc">==</span> <span class="st">"cl A"</span>)</span>
+<span id="cb15-64"><a href="#cb15-64"></a></span>
+<span id="cb15-65"><a href="#cb15-65"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb15-66"><a href="#cb15-66"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb15-67"><a href="#cb15-67"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb15-68"><a href="#cb15-68"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb15-69"><a href="#cb15-69"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-70"><a href="#cb15-70"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb15-71"><a href="#cb15-71"></a></span>
+<span id="cb15-72"><a href="#cb15-72"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-73"><a href="#cb15-73"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> pct), <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb15-74"><a href="#cb15-74"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb15-75"><a href="#cb15-75"></a>  <span class="fu">geom_text</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct, <span class="at">label =</span> pct), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">vjust =</span> <span class="sc">-</span><span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb15-76"><a href="#cb15-76"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-77"><a href="#cb15-77"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-78"><a href="#cb15-78"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-79"><a href="#cb15-79"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb15-80"><a href="#cb15-80"></a>plot</span>
+<span id="cb15-81"><a href="#cb15-81"></a><span class="in">```</span></span>
+<span id="cb15-82"><a href="#cb15-82"></a></span>
+<span id="cb15-83"><a href="#cb15-83"></a><span class="fu">## Plot of Frequency with &lt;br/&gt; Total Number of Subjects</span></span>
+<span id="cb15-84"><a href="#cb15-84"></a></span>
+<span id="cb15-85"><a href="#cb15-85"></a><span class="in">```{r plot3, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb15-86"><a href="#cb15-86"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-87"><a href="#cb15-87"></a>  <span class="fu">filter</span>(AESOC <span class="sc">==</span> <span class="st">"cl A"</span>)</span>
+<span id="cb15-88"><a href="#cb15-88"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb15-89"><a href="#cb15-89"></a></span>
+<span id="cb15-90"><a href="#cb15-90"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb15-91"><a href="#cb15-91"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb15-92"><a href="#cb15-92"></a>  <span class="fu">mutate</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb15-93"><a href="#cb15-93"></a>  <span class="fu">mutate</span>(<span class="at">xvarlabel =</span> <span class="fu">paste0</span>(ACTARM, <span class="st">"</span><span class="sc">\n\n</span><span class="st">N = "</span>, n))</span>
+<span id="cb15-94"><a href="#cb15-94"></a></span>
+<span id="cb15-95"><a href="#cb15-95"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"xvarlabel"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-96"><a href="#cb15-96"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb15-97"><a href="#cb15-97"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-98"><a href="#cb15-98"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-99"><a href="#cb15-99"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-100"><a href="#cb15-100"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>)</span>
+<span id="cb15-101"><a href="#cb15-101"></a>plot</span>
+<span id="cb15-102"><a href="#cb15-102"></a><span class="in">```</span></span>
+<span id="cb15-103"><a href="#cb15-103"></a></span>
+<span id="cb15-104"><a href="#cb15-104"></a><span class="fu">## Plot of Frequency &lt;br/&gt; with Horizontal Bars</span></span>
+<span id="cb15-105"><a href="#cb15-105"></a></span>
+<span id="cb15-106"><a href="#cb15-106"></a><span class="in">```{r plot4, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb15-107"><a href="#cb15-107"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-108"><a href="#cb15-108"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb15-109"><a href="#cb15-109"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb15-110"><a href="#cb15-110"></a></span>
+<span id="cb15-111"><a href="#cb15-111"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-112"><a href="#cb15-112"></a>  <span class="fu">geom_bar</span>(<span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb15-113"><a href="#cb15-113"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-114"><a href="#cb15-114"></a>  <span class="fu">ggtitle</span>(<span class="st">"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-115"><a href="#cb15-115"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-116"><a href="#cb15-116"></a>  <span class="fu">ylab</span>(<span class="st">"Frequency"</span>) <span class="sc">+</span></span>
+<span id="cb15-117"><a href="#cb15-117"></a>  <span class="fu">coord_flip</span>()</span>
+<span id="cb15-118"><a href="#cb15-118"></a>plot</span>
+<span id="cb15-119"><a href="#cb15-119"></a><span class="in">```</span></span>
+<span id="cb15-120"><a href="#cb15-120"></a></span>
+<span id="cb15-121"><a href="#cb15-121"></a><span class="fu">## Plot of Percentage &lt;br/&gt; and Confidence Intervals</span></span>
+<span id="cb15-122"><a href="#cb15-122"></a></span>
+<span id="cb15-123"><a href="#cb15-123"></a><span class="in">```{r plot5, test = list(plot_v5 = "plot")}</span></span>
+<span id="cb15-124"><a href="#cb15-124"></a>anl <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb15-125"><a href="#cb15-125"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span> ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span>)</span>
+<span id="cb15-126"><a href="#cb15-126"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ]</span>
+<span id="cb15-127"><a href="#cb15-127"></a></span>
+<span id="cb15-128"><a href="#cb15-128"></a>patpop5 <span class="ot">&lt;-</span> <span class="fu">as.data.frame</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-129"><a href="#cb15-129"></a>  <span class="fu">mutate</span>(<span class="at">ACTARM =</span> <span class="fu">as.vector</span>(Var1)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-130"><a href="#cb15-130"></a>  <span class="fu">mutate</span>(<span class="at">TRTPOP =</span> Freq) <span class="sc">%&gt;%</span></span>
+<span id="cb15-131"><a href="#cb15-131"></a>  <span class="fu">select</span>(ACTARM, TRTPOP)</span>
+<span id="cb15-132"><a href="#cb15-132"></a></span>
+<span id="cb15-133"><a href="#cb15-133"></a>anlpop <span class="ot">&lt;-</span> <span class="fu">as.data.frame</span>(<span class="fu">table</span>(anl<span class="sc">$</span>ANRIND, anl<span class="sc">$</span>ACTARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-134"><a href="#cb15-134"></a>  <span class="fu">filter</span>(Var1 <span class="sc">==</span> <span class="st">"HIGH"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-135"><a href="#cb15-135"></a>  <span class="fu">mutate</span>(<span class="at">ACTARM =</span> <span class="fu">as.vector</span>(Var2)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-136"><a href="#cb15-136"></a>  <span class="fu">mutate</span>(<span class="at">EVENTCOUNT =</span> Freq) <span class="sc">%&gt;%</span></span>
+<span id="cb15-137"><a href="#cb15-137"></a>  <span class="fu">select</span>(ACTARM, EVENTCOUNT)</span>
+<span id="cb15-138"><a href="#cb15-138"></a></span>
+<span id="cb15-139"><a href="#cb15-139"></a>anl <span class="ot">&lt;-</span> <span class="fu">left_join</span>(patpop5, anlpop, <span class="at">by =</span> <span class="st">"ACTARM"</span>)</span>
+<span id="cb15-140"><a href="#cb15-140"></a>CIs <span class="ot">&lt;-</span> <span class="fu">binom.confint</span>(<span class="at">x =</span> anl<span class="sc">$</span>EVENTCOUNT, <span class="at">n =</span> anl<span class="sc">$</span>TRTPOP, <span class="at">methods =</span> <span class="st">"exact"</span>)</span>
+<span id="cb15-141"><a href="#cb15-141"></a>anl <span class="ot">&lt;-</span> <span class="fu">cbind</span>(anl, CIs[, <span class="dv">4</span><span class="sc">:</span><span class="dv">6</span>])</span>
+<span id="cb15-142"><a href="#cb15-142"></a></span>
+<span id="cb15-143"><a href="#cb15-143"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl) <span class="sc">+</span></span>
+<span id="cb15-144"><a href="#cb15-144"></a>  <span class="fu">geom_bar</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> mean <span class="sc">*</span> <span class="dv">100</span>), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>], <span class="at">alpha =</span> <span class="fl">0.7</span>) <span class="sc">+</span></span>
+<span id="cb15-145"><a href="#cb15-145"></a>  <span class="fu">geom_errorbar</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">ymin =</span> lower <span class="sc">*</span> <span class="dv">100</span>, <span class="at">ymax =</span> upper <span class="sc">*</span> <span class="dv">100</span>),</span>
+<span id="cb15-146"><a href="#cb15-146"></a>    <span class="at">width =</span> <span class="fl">0.5</span>, <span class="at">colour =</span> <span class="st">"#20b4ff"</span>,</span>
+<span id="cb15-147"><a href="#cb15-147"></a>    <span class="at">alpha =</span> <span class="fl">0.9</span>, <span class="at">linewidth =</span> <span class="fl">1.0</span></span>
+<span id="cb15-148"><a href="#cb15-148"></a>  ) <span class="sc">+</span></span>
+<span id="cb15-149"><a href="#cb15-149"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-150"><a href="#cb15-150"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-151"><a href="#cb15-151"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-152"><a href="#cb15-152"></a>  <span class="fu">ylab</span>(<span class="st">"Percentage"</span>)</span>
+<span id="cb15-153"><a href="#cb15-153"></a>plot</span>
+<span id="cb15-154"><a href="#cb15-154"></a><span class="in">```</span></span>
+<span id="cb15-155"><a href="#cb15-155"></a></span>
+<span id="cb15-156"><a href="#cb15-156"></a><span class="fu">## Plot of Percentage by &lt;br/&gt; Treatment and Covariate</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a></span>
+<span id="cb15-158"><a href="#cb15-158"></a><span class="in">```{r plot6, test = list(plot_v6 = "plot")}</span></span>
+<span id="cb15-159"><a href="#cb15-159"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-160"><a href="#cb15-160"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb15-161"><a href="#cb15-161"></a></span>
+<span id="cb15-162"><a href="#cb15-162"></a>patpop6 <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">count</span>(adsl, ACTARM, SEX, <span class="at">name =</span> <span class="st">"N_arm_sex"</span>)</span>
+<span id="cb15-163"><a href="#cb15-163"></a></span>
+<span id="cb15-164"><a href="#cb15-164"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb15-165"><a href="#cb15-165"></a>  <span class="fu">group_by</span>(ACTARM, SEX) <span class="sc">%&gt;%</span></span>
+<span id="cb15-166"><a href="#cb15-166"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-167"><a href="#cb15-167"></a>  <span class="fu">left_join</span>(patpop6, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"ACTARM"</span>, <span class="st">"SEX"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-168"><a href="#cb15-168"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N_arm_sex) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb15-169"><a href="#cb15-169"></a></span>
+<span id="cb15-170"><a href="#cb15-170"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]], <span class="at">fill =</span> .data[[<span class="st">"SEX"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-171"><a href="#cb15-171"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct), <span class="at">position =</span> <span class="fu">position_dodge</span>()) <span class="sc">+</span></span>
+<span id="cb15-172"><a href="#cb15-172"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"SEX"</span>))) <span class="sc">+</span></span>
+<span id="cb15-173"><a href="#cb15-173"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb15-174"><a href="#cb15-174"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-175"><a href="#cb15-175"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-176"><a href="#cb15-176"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-177"><a href="#cb15-177"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb15-178"><a href="#cb15-178"></a>plot</span>
+<span id="cb15-179"><a href="#cb15-179"></a><span class="in">```</span></span>
+<span id="cb15-180"><a href="#cb15-180"></a></span>
+<span id="cb15-181"><a href="#cb15-181"></a><span class="fu">## Plot of Percentage by &lt;br/&gt; Covariate and Treatment</span></span>
+<span id="cb15-182"><a href="#cb15-182"></a></span>
+<span id="cb15-183"><a href="#cb15-183"></a><span class="in">```{r plot7, test = list(plot_v7 = "plot")}</span></span>
+<span id="cb15-184"><a href="#cb15-184"></a>anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-185"><a href="#cb15-185"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb15-186"><a href="#cb15-186"></a></span>
+<span id="cb15-187"><a href="#cb15-187"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb15-188"><a href="#cb15-188"></a>  <span class="fu">group_by</span>(SEX, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb15-189"><a href="#cb15-189"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-190"><a href="#cb15-190"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb15-191"><a href="#cb15-191"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-192"><a href="#cb15-192"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb15-193"><a href="#cb15-193"></a></span>
+<span id="cb15-194"><a href="#cb15-194"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"SEX"</span>]], <span class="at">fill =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-195"><a href="#cb15-195"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct), <span class="at">position =</span> <span class="fu">position_dodge</span>()) <span class="sc">+</span></span>
+<span id="cb15-196"><a href="#cb15-196"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>))) <span class="sc">+</span></span>
+<span id="cb15-197"><a href="#cb15-197"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb15-198"><a href="#cb15-198"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-199"><a href="#cb15-199"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-200"><a href="#cb15-200"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"SEX"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-201"><a href="#cb15-201"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb15-202"><a href="#cb15-202"></a>plot</span>
+<span id="cb15-203"><a href="#cb15-203"></a><span class="in">```</span></span>
+<span id="cb15-204"><a href="#cb15-204"></a></span>
+<span id="cb15-205"><a href="#cb15-205"></a><span class="fu">## Plot of Percentage &lt;br/&gt; with Mean and Median</span></span>
+<span id="cb15-206"><a href="#cb15-206"></a></span>
+<span id="cb15-207"><a href="#cb15-207"></a><span class="in">```{r plot8, test = list(plot_v8 = "plot")}</span></span>
+<span id="cb15-208"><a href="#cb15-208"></a>anl1 <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb15-209"><a href="#cb15-209"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>, PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">&amp;</span> ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span>)</span>
+<span id="cb15-210"><a href="#cb15-210"></a></span>
+<span id="cb15-211"><a href="#cb15-211"></a>anl <span class="ot">&lt;-</span> anl1[<span class="sc">!</span><span class="fu">duplicated</span>(anl1<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb15-212"><a href="#cb15-212"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb15-213"><a href="#cb15-213"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb15-214"><a href="#cb15-214"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb15-215"><a href="#cb15-215"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-216"><a href="#cb15-216"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb15-217"><a href="#cb15-217"></a></span>
+<span id="cb15-218"><a href="#cb15-218"></a>graph <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-219"><a href="#cb15-219"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> pct), <span class="at">fill =</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]) <span class="sc">+</span></span>
+<span id="cb15-220"><a href="#cb15-220"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma, <span class="at">expand =</span> <span class="fu">expansion</span>(<span class="fu">c</span>(<span class="dv">0</span>, .<span class="dv">25</span>))) <span class="sc">+</span></span>
+<span id="cb15-221"><a href="#cb15-221"></a>  <span class="fu">geom_text</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct, <span class="at">label =</span> pct), <span class="at">stat =</span> <span class="st">"identity"</span>, <span class="at">vjust =</span> <span class="sc">-</span><span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb15-222"><a href="#cb15-222"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-223"><a href="#cb15-223"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects with Abnormaly High CRP at Baseline </span><span class="sc">\n</span><span class="st"> Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-224"><a href="#cb15-224"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_lb, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-225"><a href="#cb15-225"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb15-226"><a href="#cb15-226"></a></span>
+<span id="cb15-227"><a href="#cb15-227"></a>sd_w <span class="ot">&lt;-</span> anl1 <span class="sc">%&gt;%</span></span>
+<span id="cb15-228"><a href="#cb15-228"></a>  <span class="fu">group_by</span>(ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb15-229"><a href="#cb15-229"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb15-230"><a href="#cb15-230"></a>    <span class="at">mean =</span> <span class="fu">round</span>(<span class="fu">mean</span>(AVAL, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="dv">2</span>),</span>
+<span id="cb15-231"><a href="#cb15-231"></a>    <span class="at">median =</span> <span class="fu">round</span>(<span class="fu">median</span>(AVAL, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="dv">2</span>)</span>
+<span id="cb15-232"><a href="#cb15-232"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-233"><a href="#cb15-233"></a>  <span class="fu">arrange</span>(ACTARM)</span>
+<span id="cb15-234"><a href="#cb15-234"></a></span>
+<span id="cb15-235"><a href="#cb15-235"></a>sd_l <span class="ot">&lt;-</span> <span class="fu">gather</span>(sd_w, <span class="at">key =</span> stat, <span class="at">value =</span> value, mean<span class="sc">:</span>median)</span>
+<span id="cb15-236"><a href="#cb15-236"></a>sd_l <span class="ot">&lt;-</span> sd_l <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb15-237"><a href="#cb15-237"></a>  <span class="at">stat_lbl =</span> <span class="fu">case_when</span>(</span>
+<span id="cb15-238"><a href="#cb15-238"></a>    stat <span class="sc">==</span> <span class="st">"mean"</span> <span class="sc">~</span> <span class="st">"Mean"</span>,</span>
+<span id="cb15-239"><a href="#cb15-239"></a>    stat <span class="sc">==</span> <span class="st">"median"</span> <span class="sc">~</span> <span class="st">"Median"</span></span>
+<span id="cb15-240"><a href="#cb15-240"></a>  )</span>
+<span id="cb15-241"><a href="#cb15-241"></a>)</span>
+<span id="cb15-242"><a href="#cb15-242"></a></span>
+<span id="cb15-243"><a href="#cb15-243"></a>sd_l<span class="sc">$</span>stat_lbl <span class="ot">&lt;-</span> <span class="fu">factor</span>(sd_l<span class="sc">$</span>stat_lbl, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Median"</span>, <span class="st">"Mean"</span>))</span>
+<span id="cb15-244"><a href="#cb15-244"></a></span>
+<span id="cb15-245"><a href="#cb15-245"></a>tbl_theme <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb15-246"><a href="#cb15-246"></a>  <span class="at">panel.border =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb15-247"><a href="#cb15-247"></a>  <span class="at">panel.grid.major =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb15-248"><a href="#cb15-248"></a>  <span class="at">panel.grid.minor =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb15-249"><a href="#cb15-249"></a>  <span class="at">axis.ticks =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb15-250"><a href="#cb15-250"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb15-251"><a href="#cb15-251"></a>  <span class="at">axis.text.y =</span> <span class="fu">element_text</span>(<span class="at">face =</span> <span class="st">"plain"</span>),</span>
+<span id="cb15-252"><a href="#cb15-252"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb15-253"><a href="#cb15-253"></a>)</span>
+<span id="cb15-254"><a href="#cb15-254"></a></span>
+<span id="cb15-255"><a href="#cb15-255"></a>tbl <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(sd_l, <span class="fu">aes</span>(<span class="at">x =</span> ACTARM, <span class="at">y =</span> stat_lbl, <span class="at">label =</span> value)) <span class="sc">+</span></span>
+<span id="cb15-256"><a href="#cb15-256"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb15-257"><a href="#cb15-257"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="fu">levels</span>(sd_l<span class="sc">$</span>stat_lbl)) <span class="sc">+</span></span>
+<span id="cb15-258"><a href="#cb15-258"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb15-259"><a href="#cb15-259"></a>  tbl_theme</span>
+<span id="cb15-260"><a href="#cb15-260"></a></span>
+<span id="cb15-261"><a href="#cb15-261"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(graph, tbl,</span>
+<span id="cb15-262"><a href="#cb15-262"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">4</span>, <span class="dv">1</span>),</span>
+<span id="cb15-263"><a href="#cb15-263"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb15-264"><a href="#cb15-264"></a>)</span>
+<span id="cb15-265"><a href="#cb15-265"></a>plot</span>
+<span id="cb15-266"><a href="#cb15-266"></a><span class="in">```</span></span>
+<span id="cb15-267"><a href="#cb15-267"></a></span>
+<span id="cb15-268"><a href="#cb15-268"></a><span class="fu">## Plot of Categorical &lt;br/&gt; Variable</span></span>
+<span id="cb15-269"><a href="#cb15-269"></a></span>
+<span id="cb15-270"><a href="#cb15-270"></a><span class="in">```{r plot9, test = list(plot_v9 = "plot")}</span></span>
+<span id="cb15-271"><a href="#cb15-271"></a>anl <span class="ot">&lt;-</span> adae</span>
+<span id="cb15-272"><a href="#cb15-272"></a></span>
+<span id="cb15-273"><a href="#cb15-273"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb15-274"><a href="#cb15-274"></a>  <span class="fu">arrange</span>(USUBJID, AETOXGRC) <span class="sc">%&gt;%</span></span>
+<span id="cb15-275"><a href="#cb15-275"></a>  <span class="fu">group_by</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb15-276"><a href="#cb15-276"></a>  <span class="fu">slice</span>(<span class="fu">n</span>()) <span class="sc">%&gt;%</span></span>
+<span id="cb15-277"><a href="#cb15-277"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb15-278"><a href="#cb15-278"></a></span>
+<span id="cb15-279"><a href="#cb15-279"></a>anl <span class="ot">&lt;-</span> anl[<span class="sc">!</span><span class="fu">duplicated</span>(anl<span class="sc">$</span>USUBJID), ] <span class="sc">%&gt;%</span></span>
+<span id="cb15-280"><a href="#cb15-280"></a>  <span class="fu">group_by</span>(ACTARM, AETOXGRC) <span class="sc">%&gt;%</span></span>
+<span id="cb15-281"><a href="#cb15-281"></a>  <span class="fu">summarise</span>(<span class="at">n =</span> <span class="fu">n</span>(), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-282"><a href="#cb15-282"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> patpop) <span class="sc">%&gt;%</span></span>
+<span id="cb15-283"><a href="#cb15-283"></a>  <span class="fu">mutate</span>(<span class="at">N =</span> <span class="fu">as.numeric</span>(N)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-284"><a href="#cb15-284"></a>  <span class="fu">mutate</span>(<span class="at">pct =</span> <span class="fu">round</span>((n <span class="sc">/</span> N) <span class="sc">*</span> <span class="dv">100</span>, <span class="dv">2</span>))</span>
+<span id="cb15-285"><a href="#cb15-285"></a></span>
+<span id="cb15-286"><a href="#cb15-286"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl, <span class="fu">aes</span>(<span class="at">x =</span> .data[[<span class="st">"ACTARM"</span>]], <span class="at">fill =</span> .data[[<span class="st">"AETOXGRC"</span>]])) <span class="sc">+</span></span>
+<span id="cb15-287"><a href="#cb15-287"></a>  <span class="fu">geom_col</span>(<span class="fu">aes</span>(<span class="at">y =</span> pct)) <span class="sc">+</span></span>
+<span id="cb15-288"><a href="#cb15-288"></a>  <span class="fu">guides</span>(<span class="at">fill =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="fu">getElement</span>(vl_ae, <span class="st">"AETOXGRC"</span>))) <span class="sc">+</span></span>
+<span id="cb15-289"><a href="#cb15-289"></a>  <span class="fu">scale_y_continuous</span>(<span class="at">labels =</span> scales<span class="sc">::</span>comma) <span class="sc">+</span></span>
+<span id="cb15-290"><a href="#cb15-290"></a>  <span class="fu">theme</span>(<span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="fl">0.5</span>)) <span class="sc">+</span></span>
+<span id="cb15-291"><a href="#cb15-291"></a>  <span class="fu">ggtitle</span>(<span class="st">"Percent of Subjects With AE by Highest </span><span class="sc">\n</span><span class="st"> NCI CTCAE Grade: Safety-Evaluable Subjects"</span>) <span class="sc">+</span></span>
+<span id="cb15-292"><a href="#cb15-292"></a>  <span class="fu">xlab</span>(<span class="fu">paste0</span>(<span class="fu">getElement</span>(vl_ae, <span class="st">"ACTARM"</span>), <span class="st">" (N = "</span>, denom, <span class="st">")"</span>)) <span class="sc">+</span></span>
+<span id="cb15-293"><a href="#cb15-293"></a>  <span class="fu">ylab</span>(<span class="st">"Percent"</span>)</span>
+<span id="cb15-294"><a href="#cb15-294"></a>plot</span>
+<span id="cb15-295"><a href="#cb15-295"></a><span class="in">```</span></span>
+<span id="cb15-296"><a href="#cb15-296"></a></span>
+<span id="cb15-297"><a href="#cb15-297"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-298"><a href="#cb15-298"></a></span>
+<span id="cb15-299"><a href="#cb15-299"></a><span class="fu">## `teal` App</span></span>
+<span id="cb15-300"><a href="#cb15-300"></a></span>
+<span id="cb15-301"><a href="#cb15-301"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb15-302"><a href="#cb15-302"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-303"><a href="#cb15-303"></a></span>
+<span id="cb15-304"><a href="#cb15-304"></a><span class="co"># In progress</span></span>
+<span id="cb15-305"><a href="#cb15-305"></a><span class="in">```</span></span>
+<span id="cb15-306"><a href="#cb15-306"></a></span>
+<span id="cb15-307"><a href="#cb15-307"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-308"><a href="#cb15-308"></a></span>
+<span id="cb15-309"><a href="#cb15-309"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+  <div class="sidebar-item-container"> 
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+        <li class="sidebar-item sidebar-item-section">
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+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
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+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
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+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET02_SMQ</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET04</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+          <li class="sidebar-item">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
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+ <span class="menu-text">Pharmacokinetic</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">BWG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Box Plot</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Plot</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot Changing <br> Whiskers</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot Adding <br> Outliers</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot Specifying Marker <br> for Outliers and <br> Adding Patient ID</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Plot Specifying <br> Marker for Mean</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Plot by Treatment <br> and Timepoint</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Plot by Timepoint <br> and Treatment</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Plot with <br> Table Section</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false">Plot with Number of Patients <br> only in Table Section</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-12-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-12" role="tab" aria-controls="tabset-1-12" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="bwg01_cache/html/setup_4d450fe42b7513c01ed7b623a4c3fd93">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="co"># generic code for all plots</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 2 DAY 15"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Definition of boxplot boundaries and whiskers</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>five_num <span class="ot">&lt;-</span> <span class="cf">function</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="dv">1</span>)) {</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  r <span class="ot">&lt;-</span> <span class="fu">quantile</span>(x, probs)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">names</span>(r) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ymin"</span>, <span class="st">"lower"</span>, <span class="st">"middle"</span>, <span class="st">"upper"</span>, <span class="st">"ymax"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  r</span>
+<span id="cb1-15"><a href="#cb1-15"></a>}</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># get outliers based on quantile</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a><span class="co"># for outliers based on IQR see coef in geom_boxplot</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>get_outliers <span class="ot">&lt;-</span> <span class="cf">function</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.95</span>)) {</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  r <span class="ot">&lt;-</span> <span class="fu">subset</span>(x, x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, probs[<span class="dv">1</span>]) <span class="sc">|</span> <span class="fu">quantile</span>(x, probs[<span class="dv">2</span>]) <span class="sc">&lt;</span> x)</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="cf">if</span> (<span class="sc">!</span><span class="fu">is.null</span>(x)) {</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    x_names <span class="ot">&lt;-</span> <span class="fu">subset</span>(<span class="fu">names</span>(x), x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, probs[<span class="dv">1</span>]) <span class="sc">|</span> <span class="fu">quantile</span>(x, probs[<span class="dv">2</span>]) <span class="sc">&lt;</span> x)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="fu">names</span>(r) <span class="ot">&lt;-</span> x_names</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  }</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  r</span>
+<span id="cb1-26"><a href="#cb1-26"></a>}</span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="co"># create theme used for all plots</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>theme_bp <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="at">plot.subtitle =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="at">panel.background =</span> <span class="fu">element_rect</span>(<span class="at">fill =</span> <span class="st">"white"</span>, <span class="at">color =</span> <span class="st">"grey50"</span>)</span>
+<span id="cb1-34"><a href="#cb1-34"></a>)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="co"># assign fill color and outline color</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>fc <span class="ot">&lt;-</span> <span class="st">"#eaeef5"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>oc <span class="ot">&lt;-</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]</span>
+<span id="cb1-39"><a href="#cb1-39"></a></span>
+<span id="cb1-40"><a href="#cb1-40"></a><span class="co"># get plot metadata data to derive coordinates for adding annotations</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>bp_annos <span class="ot">&lt;-</span> <span class="cf">function</span>(bp, color, <span class="at">annos =</span> <span class="dv">1</span>) {</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  bp_mdat <span class="ot">&lt;-</span> <span class="fu">ggplot_build</span>(bp)<span class="sc">$</span>data[[<span class="dv">1</span>]]</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="co"># bp_metadata &lt;&lt;- bp_mdat</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="cf">if</span> (annos <span class="sc">==</span> <span class="dv">1</span>) {</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    bp <span class="ot">&lt;-</span> bp <span class="sc">+</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb1-47"><a href="#cb1-47"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>        <span class="at">y =</span> ymax, <span class="at">yend =</span> ymax</span>
+<span id="cb1-49"><a href="#cb1-49"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb1-51"><a href="#cb1-51"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>        <span class="at">y =</span> ymin, <span class="at">yend =</span> ymin</span>
+<span id="cb1-53"><a href="#cb1-53"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color)</span>
+<span id="cb1-54"><a href="#cb1-54"></a>  } <span class="cf">else</span> {</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    bp <span class="ot">&lt;-</span> bp <span class="sc">+</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb1-57"><a href="#cb1-57"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb1-58"><a href="#cb1-58"></a>        <span class="at">y =</span> ymax, <span class="at">yend =</span> ymax</span>
+<span id="cb1-59"><a href="#cb1-59"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb1-61"><a href="#cb1-61"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>        <span class="at">y =</span> ymin, <span class="at">yend =</span> ymin</span>
+<span id="cb1-63"><a href="#cb1-63"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb1-65"><a href="#cb1-65"></a>        <span class="at">x =</span> xmin, <span class="at">xend =</span> xmax,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>        <span class="at">y =</span> middle, <span class="at">yend =</span> middle</span>
+<span id="cb1-67"><a href="#cb1-67"></a>      ), <span class="at">colour =</span> color, <span class="at">size =</span> .<span class="dv">5</span>)</span>
+<span id="cb1-68"><a href="#cb1-68"></a>  }</span>
+<span id="cb1-69"><a href="#cb1-69"></a>  <span class="fu">return</span>(bp)</span>
+<span id="cb1-70"><a href="#cb1-70"></a>}</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot1_8813ffcec637317fa412e2bea2227e3f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>bp_1 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">labs</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  theme_bp</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_1, oc)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
+ℹ Please use `linewidth` instead.</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot2_e8bf9bcd0fc45e65b0bfc883bf0cf1b1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>bp_3 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb5-3"><a href="#cb5-3"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="fu">labs</span>(</span>
+<span id="cb5-8"><a href="#cb5-8"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the 5th and 95th percentile. Values outside the whiskers have not been plotted."</span>,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb5-13"><a href="#cb5-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a>  theme_bp</span>
+<span id="cb5-15"><a href="#cb5-15"></a></span>
+<span id="cb5-16"><a href="#cb5-16"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_3, oc)</span>
+<span id="cb5-17"><a href="#cb5-17"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot3_2e323cc410266cf778ce769ed2d11aaf">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>bp_4 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb6-3"><a href="#cb6-3"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> get_outliers, <span class="at">shape =</span> <span class="dv">1</span>) <span class="sc">+</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">labs</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the 5th and 95th percentile."</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>  theme_bp</span>
+<span id="cb6-16"><a href="#cb6-16"></a></span>
+<span id="cb6-17"><a href="#cb6-17"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_4, oc)</span>
+<span id="cb6-18"><a href="#cb6-18"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot4_e401099a3bc5ecd1f72635a75aabc0f5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>adlb_o <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="fu">group_by</span>(ARMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="fu">mutate</span>(<span class="at">OUTLIER =</span> AVAL <span class="sc">&lt;</span> <span class="fu">quantile</span>(AVAL, <span class="fl">0.01</span>) <span class="sc">|</span> AVAL <span class="sc">&gt;</span> <span class="fu">quantile</span>(AVAL, <span class="fl">0.99</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a>  <span class="fu">filter</span>(OUTLIER <span class="sc">==</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a>  <span class="fu">select</span>(ARMCD, AVAL, USUBJID)</span>
+<span id="cb7-6"><a href="#cb7-6"></a><span class="co"># Next step may be study-specific: shorten USUBJID to make annotation labels</span></span>
+<span id="cb7-7"><a href="#cb7-7"></a><span class="co"># next 2 lines of code split USUBJID by "-" and take the last syllable as ID</span></span>
+<span id="cb7-8"><a href="#cb7-8"></a>n_split <span class="ot">&lt;-</span> <span class="fu">max</span>(<span class="fu">vapply</span>(<span class="fu">strsplit</span>(adlb_o<span class="sc">$</span>USUBJID, <span class="st">"-"</span>), length, <span class="fu">numeric</span>(<span class="dv">1</span>)))</span>
+<span id="cb7-9"><a href="#cb7-9"></a>adlb_o<span class="sc">$</span>ID <span class="ot">&lt;-</span> <span class="fu">vapply</span>(<span class="fu">strsplit</span>(adlb_o<span class="sc">$</span>USUBJID, <span class="st">"-"</span>), <span class="st">`</span><span class="at">[[</span><span class="st">`</span>, n_split, <span class="at">FUN.VALUE =</span> <span class="st">"a"</span>)</span>
+<span id="cb7-10"><a href="#cb7-10"></a></span>
+<span id="cb7-11"><a href="#cb7-11"></a>bp_5 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.01</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.99</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb7-15"><a href="#cb7-15"></a>  ) <span class="sc">+</span></span>
+<span id="cb7-16"><a href="#cb7-16"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb7-17"><a href="#cb7-17"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> adlb_o, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL), <span class="at">shape =</span> <span class="dv">1</span>) <span class="sc">+</span></span>
+<span id="cb7-18"><a href="#cb7-18"></a>  <span class="fu">geom_text</span>(<span class="at">data =</span> adlb_o, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">label =</span> ID), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>) <span class="sc">+</span></span>
+<span id="cb7-19"><a href="#cb7-19"></a>  <span class="fu">labs</span>(</span>
+<span id="cb7-20"><a href="#cb7-20"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb7-21"><a href="#cb7-21"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb7-22"><a href="#cb7-22"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the largest and smallest observed value within 1.5*IQR."</span>,</span>
+<span id="cb7-23"><a href="#cb7-23"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb7-25"><a href="#cb7-25"></a>  ) <span class="sc">+</span></span>
+<span id="cb7-26"><a href="#cb7-26"></a>  theme_bp</span>
+<span id="cb7-27"><a href="#cb7-27"></a></span>
+<span id="cb7-28"><a href="#cb7-28"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_5, oc)</span>
+<span id="cb7-29"><a href="#cb7-29"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot5_5d957fa4d3b0d20dd91c0879cd25a957">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>bp_6 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">geom_boxplot</span>(<span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">5</span>) <span class="sc">+</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">labs</span>(</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>  theme_bp</span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_6, oc)</span>
+<span id="cb8-14"><a href="#cb8-14"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot5-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;plot_v6&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot6_ea0894e209663a345119b468593fbdb4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb9-3"><a href="#cb9-3"></a></span>
+<span id="cb9-4"><a href="#cb9-4"></a>adlb_v <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span></span>
+<span id="cb9-6"><a href="#cb9-6"></a>    AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>bp_7 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_v, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">position =</span> <span class="fu">position_dodge2</span>(.<span class="dv">5</span>), <span class="fu">aes</span>(<span class="at">fill =</span> ARMCD, <span class="at">color =</span> ARMCD)) <span class="sc">+</span></span>
+<span id="cb9-10"><a href="#cb9-10"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="fu">aes</span>(<span class="at">group =</span> ARMCD), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb9-11"><a href="#cb9-11"></a>  <span class="fu">labs</span>(</span>
+<span id="cb9-12"><a href="#cb9-12"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb9-13"><a href="#cb9-13"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb9-14"><a href="#cb9-14"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb9-15"><a href="#cb9-15"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb9-16"><a href="#cb9-16"></a>  ) <span class="sc">+</span></span>
+<span id="cb9-17"><a href="#cb9-17"></a>  theme_bp</span>
+<span id="cb9-18"><a href="#cb9-18"></a></span>
+<span id="cb9-19"><a href="#cb9-19"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_7, oc, <span class="dv">2</span>)</span>
+<span id="cb9-20"><a href="#cb9-20"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot6-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-test="{&quot;plot_v7&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot7_71f76d07ccf0ccef8bb7358407ce422b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>bp_8 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_v, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="at">width =</span> .<span class="dv">5</span>), <span class="fu">aes</span>(<span class="at">fill =</span> AVISIT, <span class="at">color =</span> AVISIT)) <span class="sc">+</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="fu">aes</span>(<span class="at">group =</span> AVISIT), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>  <span class="fu">labs</span>(</span>
+<span id="cb10-5"><a href="#cb10-5"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb10-6"><a href="#cb10-6"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb10-7"><a href="#cb10-7"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb10-8"><a href="#cb10-8"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>  theme_bp</span>
+<span id="cb10-11"><a href="#cb10-11"></a></span>
+<span id="cb10-12"><a href="#cb10-12"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_8, oc, <span class="dv">2</span>)</span>
+<span id="cb10-13"><a href="#cb10-13"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot7-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<div class="cell" data-test="{&quot;plot_v8&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot8_3d5649729aaf0835467bc06a481f00a4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="co"># Make wide dataset with summary statistics</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a>adlb_wide <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a>  <span class="fu">group_by</span>(ARMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb11-5"><a href="#cb11-5"></a>    <span class="at">n =</span> <span class="fu">n</span>(),</span>
+<span id="cb11-6"><a href="#cb11-6"></a>    <span class="at">mean =</span> <span class="fu">round</span>(<span class="fu">mean</span>(AVAL), <span class="dv">1</span>),</span>
+<span id="cb11-7"><a href="#cb11-7"></a>    <span class="at">median =</span> <span class="fu">round</span>(<span class="fu">median</span>(AVAL), <span class="dv">1</span>),</span>
+<span id="cb11-8"><a href="#cb11-8"></a>    <span class="at">median_ci =</span> <span class="fu">paste</span>(<span class="fu">round</span>(DescTools<span class="sc">::</span><span class="fu">MedianCI</span>(AVAL)[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>], <span class="dv">1</span>), <span class="at">collapse =</span> <span class="st">" - "</span>),</span>
+<span id="cb11-9"><a href="#cb11-9"></a>    <span class="at">q1_q3 =</span> <span class="fu">paste</span>(<span class="fu">round</span>(<span class="fu">quantile</span>(AVAL, <span class="fu">c</span>(<span class="fl">0.25</span>, <span class="fl">0.75</span>)), <span class="dv">1</span>), <span class="at">collapse =</span> <span class="st">" - "</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>    <span class="at">min_max =</span> <span class="fu">paste0</span>(<span class="fu">round</span>(<span class="fu">min</span>(AVAL), <span class="dv">1</span>), <span class="st">"-"</span>, <span class="fu">max</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>)))</span>
+<span id="cb11-11"><a href="#cb11-11"></a>  )</span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="co"># Make long dataset</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a>adlb_long <span class="ot">&lt;-</span> tidyr<span class="sc">::</span><span class="fu">gather</span>(adlb_wide, <span class="at">key =</span> type, <span class="at">value =</span> stat, n<span class="sc">:</span>min_max)</span>
+<span id="cb11-15"><a href="#cb11-15"></a>adlb_long <span class="ot">&lt;-</span> adlb_long <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb11-16"><a href="#cb11-16"></a>  <span class="at">type_lbl =</span> <span class="fu">case_when</span>(</span>
+<span id="cb11-17"><a href="#cb11-17"></a>    type <span class="sc">==</span> <span class="st">"n"</span> <span class="sc">~</span> <span class="st">"n"</span>,</span>
+<span id="cb11-18"><a href="#cb11-18"></a>    type <span class="sc">==</span> <span class="st">"mean"</span> <span class="sc">~</span> <span class="st">"Mean"</span>,</span>
+<span id="cb11-19"><a href="#cb11-19"></a>    type <span class="sc">==</span> <span class="st">"median"</span> <span class="sc">~</span> <span class="st">"Median"</span>,</span>
+<span id="cb11-20"><a href="#cb11-20"></a>    type <span class="sc">==</span> <span class="st">"median_ci"</span> <span class="sc">~</span> <span class="st">"95% CI for Median"</span>,</span>
+<span id="cb11-21"><a href="#cb11-21"></a>    type <span class="sc">==</span> <span class="st">"q1_q3"</span> <span class="sc">~</span> <span class="st">"25% and 75%-ile"</span>,</span>
+<span id="cb11-22"><a href="#cb11-22"></a>    type <span class="sc">==</span> <span class="st">"min_max"</span> <span class="sc">~</span> <span class="st">"Min - Max"</span></span>
+<span id="cb11-23"><a href="#cb11-23"></a>  )</span>
+<span id="cb11-24"><a href="#cb11-24"></a>)</span>
+<span id="cb11-25"><a href="#cb11-25"></a>adlb_long<span class="sc">$</span>type_lbl <span class="ot">&lt;-</span> <span class="fu">factor</span>(adlb_long<span class="sc">$</span>type_lbl,</span>
+<span id="cb11-26"><a href="#cb11-26"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Min - Max"</span>, <span class="st">"25% and 75%-ile"</span>, <span class="st">"95% CI for Median"</span>, <span class="st">"Median"</span>, <span class="st">"Mean"</span>, <span class="st">"n"</span>)</span>
+<span id="cb11-27"><a href="#cb11-27"></a>)</span>
+<span id="cb11-28"><a href="#cb11-28"></a></span>
+<span id="cb11-29"><a href="#cb11-29"></a>bp_9 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb11-32"><a href="#cb11-32"></a>  <span class="fu">labs</span>(</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb11-36"><a href="#cb11-36"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb11-37"><a href="#cb11-37"></a>  ) <span class="sc">+</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>  theme_bp</span>
+<span id="cb11-39"><a href="#cb11-39"></a></span>
+<span id="cb11-40"><a href="#cb11-40"></a>tbl_theme <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb11-41"><a href="#cb11-41"></a>  <span class="at">panel.border =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb11-42"><a href="#cb11-42"></a>  <span class="at">panel.grid.major =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb11-43"><a href="#cb11-43"></a>  <span class="at">panel.grid.minor =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb11-44"><a href="#cb11-44"></a>  <span class="at">axis.ticks =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb11-45"><a href="#cb11-45"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb11-46"><a href="#cb11-46"></a>  <span class="at">axis.text.y =</span> <span class="fu">element_text</span>(<span class="at">face =</span> <span class="st">"plain"</span>),</span>
+<span id="cb11-47"><a href="#cb11-47"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb11-48"><a href="#cb11-48"></a>)</span>
+<span id="cb11-49"><a href="#cb11-49"></a></span>
+<span id="cb11-50"><a href="#cb11-50"></a>tbl_1 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_long, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> type_lbl, <span class="at">label =</span> stat), <span class="at">vjust =</span> <span class="dv">10</span>) <span class="sc">+</span></span>
+<span id="cb11-51"><a href="#cb11-51"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb11-52"><a href="#cb11-52"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="fu">levels</span>(adlb_long<span class="sc">$</span>type_lbl)) <span class="sc">+</span></span>
+<span id="cb11-53"><a href="#cb11-53"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb11-54"><a href="#cb11-54"></a>  tbl_theme <span class="sc">+</span></span>
+<span id="cb11-55"><a href="#cb11-55"></a>  <span class="fu">labs</span>(<span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>) <span class="sc">+</span></span>
+<span id="cb11-56"><a href="#cb11-56"></a>  theme_bp</span>
+<span id="cb11-57"><a href="#cb11-57"></a></span>
+<span id="cb11-58"><a href="#cb11-58"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(<span class="fu">bp_annos</span>(bp_9, oc), tbl_1,</span>
+<span id="cb11-59"><a href="#cb11-59"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">4</span>, <span class="dv">2</span>),</span>
+<span id="cb11-60"><a href="#cb11-60"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb11-61"><a href="#cb11-61"></a>)</span>
+<span id="cb11-62"><a href="#cb11-62"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot8-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-test="{&quot;plot_v9&quot;:&quot;plot&quot;}" data-hash="bwg01_cache/html/plot9_e0861440cba634ac10cbda1d1ec534f3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>tbl_2 <span class="ot">&lt;-</span> adlb_long <span class="sc">%&gt;%</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a>  <span class="fu">filter</span>(type <span class="sc">==</span> <span class="st">"n"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a>  <span class="fu">ggplot</span>(<span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> type_lbl, <span class="at">label =</span> stat)) <span class="sc">+</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="st">"n"</span>) <span class="sc">+</span></span>
+<span id="cb12-6"><a href="#cb12-6"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb12-7"><a href="#cb12-7"></a>  tbl_theme <span class="sc">+</span></span>
+<span id="cb12-8"><a href="#cb12-8"></a>  <span class="fu">labs</span>(<span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>) <span class="sc">+</span></span>
+<span id="cb12-9"><a href="#cb12-9"></a>  theme_bp</span>
+<span id="cb12-10"><a href="#cb12-10"></a></span>
+<span id="cb12-11"><a href="#cb12-11"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(<span class="fu">bp_annos</span>(bp_9, oc), tbl_2,</span>
+<span id="cb12-12"><a href="#cb12-12"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">1</span>),</span>
+<span id="cb12-13"><a href="#cb12-13"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a>)</span>
+<span id="cb12-15"><a href="#cb12-15"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/plot9-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="bwg01_cache/html/teal_821e9299e27ee25831effc97b4a35527">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb13-2"><a href="#cb13-2"></a><span class="fu">library</span>(teal.modules.general)</span>
+<span id="cb13-3"><a href="#cb13-3"></a></span>
+<span id="cb13-4"><a href="#cb13-4"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb13-5"><a href="#cb13-5"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb13-6"><a href="#cb13-6"></a></span>
+<span id="cb13-7"><a href="#cb13-7"></a><span class="co"># If PARAMCD and AVISIT are not factors, convert to factors</span></span>
+<span id="cb13-8"><a href="#cb13-8"></a><span class="co"># Also fill in missing values with "&lt;Missing&gt;"</span></span>
+<span id="cb13-9"><a href="#cb13-9"></a>ADLB <span class="ot">&lt;-</span> ADLB <span class="sc">%&gt;%</span></span>
+<span id="cb13-10"><a href="#cb13-10"></a>  tern<span class="sc">::</span><span class="fu">df_explicit_na</span>(</span>
+<span id="cb13-11"><a href="#cb13-11"></a>    <span class="at">omit_columns =</span> <span class="fu">setdiff</span>(<span class="fu">names</span>(ADLB), <span class="fu">c</span>(<span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb13-12"><a href="#cb13-12"></a>    <span class="at">char_as_factor =</span> <span class="cn">TRUE</span></span>
+<span id="cb13-13"><a href="#cb13-13"></a>  )</span>
+<span id="cb13-14"><a href="#cb13-14"></a></span>
+<span id="cb13-15"><a href="#cb13-15"></a><span class="co"># If statment below fails, pre-process ADLB to be one record per</span></span>
+<span id="cb13-16"><a href="#cb13-16"></a><span class="co"># study, subject, param and visit eg. filter with ANLFL = 'Y'</span></span>
+<span id="cb13-17"><a href="#cb13-17"></a><span class="fu">stopifnot</span>(<span class="fu">nrow</span>(ADLB) <span class="sc">==</span> <span class="fu">nrow</span>(<span class="fu">unique</span>(ADLB[, <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)])))</span>
+<span id="cb13-18"><a href="#cb13-18"></a></span>
+<span id="cb13-19"><a href="#cb13-19"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb13-20"><a href="#cb13-20"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb13-21"><a href="#cb13-21"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb13-22"><a href="#cb13-22"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)), <span class="co"># do not modify</span></span>
+<span id="cb13-23"><a href="#cb13-23"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb13-24"><a href="#cb13-24"></a><span class="st">    ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")</span></span>
+<span id="cb13-25"><a href="#cb13-25"></a><span class="st">    ADLB &lt;- ADLB %&gt;%</span></span>
+<span id="cb13-26"><a href="#cb13-26"></a><span class="st">      tern::df_explicit_na(</span></span>
+<span id="cb13-27"><a href="#cb13-27"></a><span class="st">        omit_columns = setdiff(names(ADLB), c("PARAMCD", "AVISIT")),</span></span>
+<span id="cb13-28"><a href="#cb13-28"></a><span class="st">        char_as_factor = TRUE)'</span></span>
+<span id="cb13-29"><a href="#cb13-29"></a>  ),</span>
+<span id="cb13-30"><a href="#cb13-30"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb13-31"><a href="#cb13-31"></a>    <span class="fu">tm_g_bivariate</span>(</span>
+<span id="cb13-32"><a href="#cb13-32"></a>      <span class="at">x =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb13-33"><a href="#cb13-33"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb13-34"><a href="#cb13-34"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb13-35"><a href="#cb13-35"></a>          <span class="at">label =</span> <span class="st">"Select variable:"</span>,</span>
+<span id="cb13-36"><a href="#cb13-36"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADSL),</span>
+<span id="cb13-37"><a href="#cb13-37"></a>          <span class="at">selected =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb13-38"><a href="#cb13-38"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb13-39"><a href="#cb13-39"></a>        )</span>
+<span id="cb13-40"><a href="#cb13-40"></a>      ),</span>
+<span id="cb13-41"><a href="#cb13-41"></a>      <span class="at">y =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb13-42"><a href="#cb13-42"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb13-43"><a href="#cb13-43"></a>        <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb13-44"><a href="#cb13-44"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb13-45"><a href="#cb13-45"></a>            <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"PARAMCD"</span>),</span>
+<span id="cb13-46"><a href="#cb13-46"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD),</span>
+<span id="cb13-47"><a href="#cb13-47"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>],</span>
+<span id="cb13-48"><a href="#cb13-48"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-49"><a href="#cb13-49"></a>            <span class="at">label =</span> <span class="st">"Choose lab parameter"</span></span>
+<span id="cb13-50"><a href="#cb13-50"></a>          ),</span>
+<span id="cb13-51"><a href="#cb13-51"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb13-52"><a href="#cb13-52"></a>            <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>),</span>
+<span id="cb13-53"><a href="#cb13-53"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT),</span>
+<span id="cb13-54"><a href="#cb13-54"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT)[<span class="dv">1</span>],</span>
+<span id="cb13-55"><a href="#cb13-55"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-56"><a href="#cb13-56"></a>            <span class="at">label =</span> <span class="st">"Choose visit"</span></span>
+<span id="cb13-57"><a href="#cb13-57"></a>          )</span>
+<span id="cb13-58"><a href="#cb13-58"></a>        ),</span>
+<span id="cb13-59"><a href="#cb13-59"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb13-60"><a href="#cb13-60"></a>          <span class="at">label =</span> <span class="st">"Select variable:"</span>,</span>
+<span id="cb13-61"><a href="#cb13-61"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb13-62"><a href="#cb13-62"></a>          <span class="at">selected =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb13-63"><a href="#cb13-63"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-64"><a href="#cb13-64"></a>          <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb13-65"><a href="#cb13-65"></a>        )</span>
+<span id="cb13-66"><a href="#cb13-66"></a>      ),</span>
+<span id="cb13-67"><a href="#cb13-67"></a>      <span class="at">row_facet =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb13-68"><a href="#cb13-68"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb13-69"><a href="#cb13-69"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb13-70"><a href="#cb13-70"></a>          <span class="at">label =</span> <span class="st">"Select variables:"</span>,</span>
+<span id="cb13-71"><a href="#cb13-71"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb13-72"><a href="#cb13-72"></a>          <span class="at">selected =</span> <span class="cn">NULL</span>,</span>
+<span id="cb13-73"><a href="#cb13-73"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-74"><a href="#cb13-74"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb13-75"><a href="#cb13-75"></a>        )</span>
+<span id="cb13-76"><a href="#cb13-76"></a>      ),</span>
+<span id="cb13-77"><a href="#cb13-77"></a>      <span class="at">col_facet =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb13-78"><a href="#cb13-78"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb13-79"><a href="#cb13-79"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb13-80"><a href="#cb13-80"></a>          <span class="at">label =</span> <span class="st">"Select variables:"</span>,</span>
+<span id="cb13-81"><a href="#cb13-81"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb13-82"><a href="#cb13-82"></a>          <span class="at">selected =</span> <span class="cn">NULL</span>,</span>
+<span id="cb13-83"><a href="#cb13-83"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-84"><a href="#cb13-84"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb13-85"><a href="#cb13-85"></a>        )</span>
+<span id="cb13-86"><a href="#cb13-86"></a>      )</span>
+<span id="cb13-87"><a href="#cb13-87"></a>    )</span>
+<span id="cb13-88"><a href="#cb13-88"></a>  )</span>
+<span id="cb13-89"><a href="#cb13-89"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:52:18.1727 pid:6308 token:[] teal.modules.general Initializing tm_g_bivariate</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="bwg01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-12" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-12-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="bwg01_cache/html/sessioninfo_612a087188b024f1712609262ea478ed">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.general_0.2.16 teal_0.14.0                
+ [3] teal.transform_0.4.0        magrittr_2.0.3             
+ [5] teal.slice_0.4.0            teal.data_0.3.0            
+ [7] shinyTree_0.3.1             shiny_1.7.5                
+ [9] ggmosaic_0.3.3              nestcolor_0.1.2            
+[11] ggplot2_3.4.3               dplyr_1.1.3                
+[13] scda_0.1.6                 
+
+loaded via a namespace (and not attached):
+  [1] Rdpack_2.5            gld_2.6.6             logger_0.2.2         
+  [4] testthat_3.1.10       readxl_1.4.3          rlang_1.1.1          
+  [7] e1071_1.7-13          compiler_4.3.1        callr_3.7.3          
+ [10] vctrs_0.6.3           formatters_0.5.2      stringr_1.5.0        
+ [13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      
+ [16] ellipsis_0.3.2        fontawesome_0.5.2     labeling_0.4.3       
+ [19] utf8_1.2.3            promises_1.2.1        rmarkdown_2.25       
+ [22] ps_1.7.5              purrr_1.0.2           xfun_0.40            
+ [25] cachem_1.0.8          teal.reporter_0.2.1   jsonlite_1.8.7       
+ [28] later_1.3.1           broom_1.0.5           DescTools_0.99.50    
+ [31] R6_2.5.1              bslib_0.5.1           stringi_1.7.12       
+ [34] car_3.1-2             boot_1.3-28.1         jquerylib_0.1.4      
+ [37] brio_1.1.3            cellranger_1.1.0      Rcpp_1.0.11          
+ [40] rtables_0.6.3         knitr_1.44            teal.logger_0.1.3    
+ [43] httpuv_1.6.11         Matrix_1.6-1.1        splines_4.3.1        
+ [46] tidyselect_1.2.0      rstudioapi_0.15.0     abind_1.4-5          
+ [49] yaml_2.3.7            codetools_0.2-19      processx_3.8.2       
+ [52] teal.widgets_0.4.0    lattice_0.21-8        tibble_3.2.1         
+ [55] withr_2.5.0           evaluate_0.21         survival_3.5-7       
+ [58] proxy_0.4-27          shinycssloaders_1.0.0 pillar_1.9.0         
+ [61] ggpubr_0.6.0          carData_3.0-5         checkmate_2.2.0      
+ [64] shinyjs_2.1.0         plotly_4.10.2         generics_0.1.3       
+ [67] munsell_0.5.0         scales_1.2.1          rootSolve_1.8.2.4    
+ [70] xtable_1.8-4          class_7.3-22          glue_1.6.2           
+ [73] lmom_3.0              lazyeval_0.2.2        tools_4.3.1          
+ [76] data.table_1.14.8     webshot_0.5.5         ggsignif_0.6.4       
+ [79] forcats_1.0.0         Exact_3.2             mvtnorm_1.2-3        
+ [82] cowplot_1.1.1         grid_4.3.1            tidyr_1.3.0          
+ [85] rbibutils_2.2.15      colorspace_2.1-0      cli_3.6.1            
+ [88] tern_0.9.0            fansi_1.0.4           expm_0.999-7         
+ [91] viridisLite_0.4.2     gtable_0.3.4          rstatix_0.7.2        
+ [94] sass_0.4.7            digest_0.6.33         ggrepel_0.9.3        
+ [97] htmlwidgets_1.6.2     farver_2.1.1          memoise_2.0.1        
+[100] htmltools_0.5.6       lifecycle_1.0.3       shinyWidgets_0.8.0   
+[103] httr_1.4.7            mime_0.12             MASS_7.3-60          </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="bwg01_cache/html/snapshot_16b783679dbd056abbd7efd641bb6dfe">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb18-2"><a href="#cb18-2"></a></span>
+<span id="cb18-3"><a href="#cb18-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb18-7"><a href="#cb18-7"></a></span>
+<span id="cb18-8"><a href="#cb18-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb18-9"><a href="#cb18-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb18-10"><a href="#cb18-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb18-11"><a href="#cb18-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/bwg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
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+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
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+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
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+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb19" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb19-1"><a href="#cb19-1"></a><span class="co">---</span></span>
+<span id="cb19-2"><a href="#cb19-2"></a><span class="an">title:</span><span class="co"> BWG01</span></span>
+<span id="cb19-3"><a href="#cb19-3"></a><span class="an">subtitle:</span><span class="co"> Box Plot</span></span>
+<span id="cb19-4"><a href="#cb19-4"></a><span class="co">---</span></span>
+<span id="cb19-5"><a href="#cb19-5"></a></span>
+<span id="cb19-6"><a href="#cb19-6"></a>------------------------------------------------------------------------</span>
+<span id="cb19-7"><a href="#cb19-7"></a></span>
+<span id="cb19-8"><a href="#cb19-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb19-9"><a href="#cb19-9"></a></span>
+<span id="cb19-10"><a href="#cb19-10"></a>::: panel-tabset</span>
+<span id="cb19-11"><a href="#cb19-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb19-12"><a href="#cb19-12"></a></span>
+<span id="cb19-13"><a href="#cb19-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb19-14"><a href="#cb19-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb19-15"><a href="#cb19-15"></a></span>
+<span id="cb19-16"><a href="#cb19-16"></a><span class="co"># generic code for all plots</span></span>
+<span id="cb19-17"><a href="#cb19-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb19-18"><a href="#cb19-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb19-19"><a href="#cb19-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb19-20"><a href="#cb19-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb19-21"><a href="#cb19-21"></a></span>
+<span id="cb19-22"><a href="#cb19-22"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb19-23"><a href="#cb19-23"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 2 DAY 15"</span>)</span>
+<span id="cb19-24"><a href="#cb19-24"></a></span>
+<span id="cb19-25"><a href="#cb19-25"></a><span class="co"># Definition of boxplot boundaries and whiskers</span></span>
+<span id="cb19-26"><a href="#cb19-26"></a>five_num <span class="ot">&lt;-</span> <span class="cf">function</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="dv">1</span>)) {</span>
+<span id="cb19-27"><a href="#cb19-27"></a>  r <span class="ot">&lt;-</span> <span class="fu">quantile</span>(x, probs)</span>
+<span id="cb19-28"><a href="#cb19-28"></a>  <span class="fu">names</span>(r) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ymin"</span>, <span class="st">"lower"</span>, <span class="st">"middle"</span>, <span class="st">"upper"</span>, <span class="st">"ymax"</span>)</span>
+<span id="cb19-29"><a href="#cb19-29"></a>  r</span>
+<span id="cb19-30"><a href="#cb19-30"></a>}</span>
+<span id="cb19-31"><a href="#cb19-31"></a></span>
+<span id="cb19-32"><a href="#cb19-32"></a><span class="co"># get outliers based on quantile</span></span>
+<span id="cb19-33"><a href="#cb19-33"></a><span class="co"># for outliers based on IQR see coef in geom_boxplot</span></span>
+<span id="cb19-34"><a href="#cb19-34"></a>get_outliers <span class="ot">&lt;-</span> <span class="cf">function</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.95</span>)) {</span>
+<span id="cb19-35"><a href="#cb19-35"></a>  r <span class="ot">&lt;-</span> <span class="fu">subset</span>(x, x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, probs[<span class="dv">1</span>]) <span class="sc">|</span> <span class="fu">quantile</span>(x, probs[<span class="dv">2</span>]) <span class="sc">&lt;</span> x)</span>
+<span id="cb19-36"><a href="#cb19-36"></a>  <span class="cf">if</span> (<span class="sc">!</span><span class="fu">is.null</span>(x)) {</span>
+<span id="cb19-37"><a href="#cb19-37"></a>    x_names <span class="ot">&lt;-</span> <span class="fu">subset</span>(<span class="fu">names</span>(x), x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, probs[<span class="dv">1</span>]) <span class="sc">|</span> <span class="fu">quantile</span>(x, probs[<span class="dv">2</span>]) <span class="sc">&lt;</span> x)</span>
+<span id="cb19-38"><a href="#cb19-38"></a>    <span class="fu">names</span>(r) <span class="ot">&lt;-</span> x_names</span>
+<span id="cb19-39"><a href="#cb19-39"></a>  }</span>
+<span id="cb19-40"><a href="#cb19-40"></a>  r</span>
+<span id="cb19-41"><a href="#cb19-41"></a>}</span>
+<span id="cb19-42"><a href="#cb19-42"></a></span>
+<span id="cb19-43"><a href="#cb19-43"></a><span class="co"># create theme used for all plots</span></span>
+<span id="cb19-44"><a href="#cb19-44"></a>theme_bp <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb19-45"><a href="#cb19-45"></a>  <span class="at">plot.title =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb19-46"><a href="#cb19-46"></a>  <span class="at">plot.subtitle =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb19-47"><a href="#cb19-47"></a>  <span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>),</span>
+<span id="cb19-48"><a href="#cb19-48"></a>  <span class="at">panel.background =</span> <span class="fu">element_rect</span>(<span class="at">fill =</span> <span class="st">"white"</span>, <span class="at">color =</span> <span class="st">"grey50"</span>)</span>
+<span id="cb19-49"><a href="#cb19-49"></a>)</span>
+<span id="cb19-50"><a href="#cb19-50"></a></span>
+<span id="cb19-51"><a href="#cb19-51"></a><span class="co"># assign fill color and outline color</span></span>
+<span id="cb19-52"><a href="#cb19-52"></a>fc <span class="ot">&lt;-</span> <span class="st">"#eaeef5"</span></span>
+<span id="cb19-53"><a href="#cb19-53"></a>oc <span class="ot">&lt;-</span> <span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.fill"</span>)[<span class="dv">1</span>]</span>
+<span id="cb19-54"><a href="#cb19-54"></a></span>
+<span id="cb19-55"><a href="#cb19-55"></a><span class="co"># get plot metadata data to derive coordinates for adding annotations</span></span>
+<span id="cb19-56"><a href="#cb19-56"></a>bp_annos <span class="ot">&lt;-</span> <span class="cf">function</span>(bp, color, <span class="at">annos =</span> <span class="dv">1</span>) {</span>
+<span id="cb19-57"><a href="#cb19-57"></a>  bp_mdat <span class="ot">&lt;-</span> <span class="fu">ggplot_build</span>(bp)<span class="sc">$</span>data[[<span class="dv">1</span>]]</span>
+<span id="cb19-58"><a href="#cb19-58"></a>  <span class="co"># bp_metadata &lt;&lt;- bp_mdat</span></span>
+<span id="cb19-59"><a href="#cb19-59"></a>  <span class="cf">if</span> (annos <span class="sc">==</span> <span class="dv">1</span>) {</span>
+<span id="cb19-60"><a href="#cb19-60"></a>    bp <span class="ot">&lt;-</span> bp <span class="sc">+</span></span>
+<span id="cb19-61"><a href="#cb19-61"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb19-62"><a href="#cb19-62"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb19-63"><a href="#cb19-63"></a>        <span class="at">y =</span> ymax, <span class="at">yend =</span> ymax</span>
+<span id="cb19-64"><a href="#cb19-64"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb19-65"><a href="#cb19-65"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb19-66"><a href="#cb19-66"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb19-67"><a href="#cb19-67"></a>        <span class="at">y =</span> ymin, <span class="at">yend =</span> ymin</span>
+<span id="cb19-68"><a href="#cb19-68"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color)</span>
+<span id="cb19-69"><a href="#cb19-69"></a>  } <span class="cf">else</span> {</span>
+<span id="cb19-70"><a href="#cb19-70"></a>    bp <span class="ot">&lt;-</span> bp <span class="sc">+</span></span>
+<span id="cb19-71"><a href="#cb19-71"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb19-72"><a href="#cb19-72"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb19-73"><a href="#cb19-73"></a>        <span class="at">y =</span> ymax, <span class="at">yend =</span> ymax</span>
+<span id="cb19-74"><a href="#cb19-74"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb19-75"><a href="#cb19-75"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb19-76"><a href="#cb19-76"></a>        <span class="at">x =</span> xmin <span class="sc">+</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>, <span class="at">xend =</span> xmax <span class="sc">-</span> (xmax <span class="sc">-</span> xmin) <span class="sc">/</span> <span class="dv">4</span>,</span>
+<span id="cb19-77"><a href="#cb19-77"></a>        <span class="at">y =</span> ymin, <span class="at">yend =</span> ymin</span>
+<span id="cb19-78"><a href="#cb19-78"></a>      ), <span class="at">size =</span> .<span class="dv">5</span>, <span class="at">color =</span> color) <span class="sc">+</span></span>
+<span id="cb19-79"><a href="#cb19-79"></a>      <span class="fu">geom_segment</span>(<span class="at">data =</span> bp_mdat, <span class="fu">aes</span>(</span>
+<span id="cb19-80"><a href="#cb19-80"></a>        <span class="at">x =</span> xmin, <span class="at">xend =</span> xmax,</span>
+<span id="cb19-81"><a href="#cb19-81"></a>        <span class="at">y =</span> middle, <span class="at">yend =</span> middle</span>
+<span id="cb19-82"><a href="#cb19-82"></a>      ), <span class="at">colour =</span> color, <span class="at">size =</span> .<span class="dv">5</span>)</span>
+<span id="cb19-83"><a href="#cb19-83"></a>  }</span>
+<span id="cb19-84"><a href="#cb19-84"></a>  <span class="fu">return</span>(bp)</span>
+<span id="cb19-85"><a href="#cb19-85"></a>}</span>
+<span id="cb19-86"><a href="#cb19-86"></a><span class="in">```</span></span>
+<span id="cb19-87"><a href="#cb19-87"></a></span>
+<span id="cb19-88"><a href="#cb19-88"></a><span class="fu">## Standard Plot</span></span>
+<span id="cb19-89"><a href="#cb19-89"></a></span>
+<span id="cb19-90"><a href="#cb19-90"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb19-91"><a href="#cb19-91"></a>bp_1 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-92"><a href="#cb19-92"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb19-93"><a href="#cb19-93"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb19-94"><a href="#cb19-94"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-95"><a href="#cb19-95"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-96"><a href="#cb19-96"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-97"><a href="#cb19-97"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb19-98"><a href="#cb19-98"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-99"><a href="#cb19-99"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-100"><a href="#cb19-100"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-101"><a href="#cb19-101"></a>  theme_bp</span>
+<span id="cb19-102"><a href="#cb19-102"></a></span>
+<span id="cb19-103"><a href="#cb19-103"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_1, oc)</span>
+<span id="cb19-104"><a href="#cb19-104"></a>plot</span>
+<span id="cb19-105"><a href="#cb19-105"></a><span class="in">```</span></span>
+<span id="cb19-106"><a href="#cb19-106"></a></span>
+<span id="cb19-107"><a href="#cb19-107"></a><span class="fu">## Plot Changing &lt;br/&gt; Whiskers</span></span>
+<span id="cb19-108"><a href="#cb19-108"></a></span>
+<span id="cb19-109"><a href="#cb19-109"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb19-110"><a href="#cb19-110"></a>bp_3 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-111"><a href="#cb19-111"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb19-112"><a href="#cb19-112"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb19-113"><a href="#cb19-113"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb19-114"><a href="#cb19-114"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-115"><a href="#cb19-115"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb19-116"><a href="#cb19-116"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-117"><a href="#cb19-117"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-118"><a href="#cb19-118"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-119"><a href="#cb19-119"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the 5th and 95th percentile. Values outside the whiskers have not been plotted."</span>,</span>
+<span id="cb19-120"><a href="#cb19-120"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-121"><a href="#cb19-121"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-122"><a href="#cb19-122"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-123"><a href="#cb19-123"></a>  theme_bp</span>
+<span id="cb19-124"><a href="#cb19-124"></a></span>
+<span id="cb19-125"><a href="#cb19-125"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_3, oc)</span>
+<span id="cb19-126"><a href="#cb19-126"></a>plot</span>
+<span id="cb19-127"><a href="#cb19-127"></a><span class="in">```</span></span>
+<span id="cb19-128"><a href="#cb19-128"></a></span>
+<span id="cb19-129"><a href="#cb19-129"></a><span class="fu">## Plot Adding &lt;br/&gt; Outliers</span></span>
+<span id="cb19-130"><a href="#cb19-130"></a></span>
+<span id="cb19-131"><a href="#cb19-131"></a><span class="in">```{r plot3, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb19-132"><a href="#cb19-132"></a>bp_4 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-133"><a href="#cb19-133"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb19-134"><a href="#cb19-134"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb19-135"><a href="#cb19-135"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb19-136"><a href="#cb19-136"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-137"><a href="#cb19-137"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> get_outliers, <span class="at">shape =</span> <span class="dv">1</span>) <span class="sc">+</span></span>
+<span id="cb19-138"><a href="#cb19-138"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb19-139"><a href="#cb19-139"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-140"><a href="#cb19-140"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-141"><a href="#cb19-141"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-142"><a href="#cb19-142"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the 5th and 95th percentile."</span>,</span>
+<span id="cb19-143"><a href="#cb19-143"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-144"><a href="#cb19-144"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-145"><a href="#cb19-145"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-146"><a href="#cb19-146"></a>  theme_bp</span>
+<span id="cb19-147"><a href="#cb19-147"></a></span>
+<span id="cb19-148"><a href="#cb19-148"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_4, oc)</span>
+<span id="cb19-149"><a href="#cb19-149"></a>plot</span>
+<span id="cb19-150"><a href="#cb19-150"></a><span class="in">```</span></span>
+<span id="cb19-151"><a href="#cb19-151"></a></span>
+<span id="cb19-152"><a href="#cb19-152"></a><span class="fu">## Plot Specifying Marker &lt;br/&gt; for Outliers and &lt;br/&gt; Adding Patient ID</span></span>
+<span id="cb19-153"><a href="#cb19-153"></a></span>
+<span id="cb19-154"><a href="#cb19-154"></a><span class="in">```{r plot4, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb19-155"><a href="#cb19-155"></a>adlb_o <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb19-156"><a href="#cb19-156"></a>  <span class="fu">group_by</span>(ARMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb19-157"><a href="#cb19-157"></a>  <span class="fu">mutate</span>(<span class="at">OUTLIER =</span> AVAL <span class="sc">&lt;</span> <span class="fu">quantile</span>(AVAL, <span class="fl">0.01</span>) <span class="sc">|</span> AVAL <span class="sc">&gt;</span> <span class="fu">quantile</span>(AVAL, <span class="fl">0.99</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb19-158"><a href="#cb19-158"></a>  <span class="fu">filter</span>(OUTLIER <span class="sc">==</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb19-159"><a href="#cb19-159"></a>  <span class="fu">select</span>(ARMCD, AVAL, USUBJID)</span>
+<span id="cb19-160"><a href="#cb19-160"></a><span class="co"># Next step may be study-specific: shorten USUBJID to make annotation labels</span></span>
+<span id="cb19-161"><a href="#cb19-161"></a><span class="co"># next 2 lines of code split USUBJID by "-" and take the last syllable as ID</span></span>
+<span id="cb19-162"><a href="#cb19-162"></a>n_split <span class="ot">&lt;-</span> <span class="fu">max</span>(<span class="fu">vapply</span>(<span class="fu">strsplit</span>(adlb_o<span class="sc">$</span>USUBJID, <span class="st">"-"</span>), length, <span class="fu">numeric</span>(<span class="dv">1</span>)))</span>
+<span id="cb19-163"><a href="#cb19-163"></a>adlb_o<span class="sc">$</span>ID <span class="ot">&lt;-</span> <span class="fu">vapply</span>(<span class="fu">strsplit</span>(adlb_o<span class="sc">$</span>USUBJID, <span class="st">"-"</span>), <span class="st">`</span><span class="at">[[</span><span class="st">`</span>, n_split, <span class="at">FUN.VALUE =</span> <span class="st">"a"</span>)</span>
+<span id="cb19-164"><a href="#cb19-164"></a></span>
+<span id="cb19-165"><a href="#cb19-165"></a>bp_5 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-166"><a href="#cb19-166"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb19-167"><a href="#cb19-167"></a>    <span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num,</span>
+<span id="cb19-168"><a href="#cb19-168"></a>    <span class="at">fun.args =</span> <span class="fu">list</span>(<span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.01</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.99</span>)), <span class="at">fill =</span> fc, <span class="at">color =</span> oc</span>
+<span id="cb19-169"><a href="#cb19-169"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-170"><a href="#cb19-170"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb19-171"><a href="#cb19-171"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> adlb_o, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL), <span class="at">shape =</span> <span class="dv">1</span>) <span class="sc">+</span></span>
+<span id="cb19-172"><a href="#cb19-172"></a>  <span class="fu">geom_text</span>(<span class="at">data =</span> adlb_o, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">label =</span> ID), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>) <span class="sc">+</span></span>
+<span id="cb19-173"><a href="#cb19-173"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-174"><a href="#cb19-174"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-175"><a href="#cb19-175"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-176"><a href="#cb19-176"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the largest and smallest observed value within 1.5*IQR."</span>,</span>
+<span id="cb19-177"><a href="#cb19-177"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-178"><a href="#cb19-178"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-179"><a href="#cb19-179"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-180"><a href="#cb19-180"></a>  theme_bp</span>
+<span id="cb19-181"><a href="#cb19-181"></a></span>
+<span id="cb19-182"><a href="#cb19-182"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_5, oc)</span>
+<span id="cb19-183"><a href="#cb19-183"></a>plot</span>
+<span id="cb19-184"><a href="#cb19-184"></a><span class="in">```</span></span>
+<span id="cb19-185"><a href="#cb19-185"></a></span>
+<span id="cb19-186"><a href="#cb19-186"></a><span class="fu">## Plot Specifying &lt;br/&gt; Marker for Mean</span></span>
+<span id="cb19-187"><a href="#cb19-187"></a></span>
+<span id="cb19-188"><a href="#cb19-188"></a><span class="in">```{r plot5, test = list(plot_v5 = "plot")}</span></span>
+<span id="cb19-189"><a href="#cb19-189"></a>bp_6 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-190"><a href="#cb19-190"></a>  <span class="fu">geom_boxplot</span>(<span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb19-191"><a href="#cb19-191"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">5</span>) <span class="sc">+</span></span>
+<span id="cb19-192"><a href="#cb19-192"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-193"><a href="#cb19-193"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-194"><a href="#cb19-194"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-195"><a href="#cb19-195"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb19-196"><a href="#cb19-196"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-197"><a href="#cb19-197"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-198"><a href="#cb19-198"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-199"><a href="#cb19-199"></a>  theme_bp</span>
+<span id="cb19-200"><a href="#cb19-200"></a></span>
+<span id="cb19-201"><a href="#cb19-201"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_6, oc)</span>
+<span id="cb19-202"><a href="#cb19-202"></a>plot</span>
+<span id="cb19-203"><a href="#cb19-203"></a><span class="in">```</span></span>
+<span id="cb19-204"><a href="#cb19-204"></a></span>
+<span id="cb19-205"><a href="#cb19-205"></a><span class="fu">## Plot by Treatment &lt;br/&gt; and Timepoint</span></span>
+<span id="cb19-206"><a href="#cb19-206"></a></span>
+<span id="cb19-207"><a href="#cb19-207"></a><span class="in">```{r plot6, test = list(plot_v6 = "plot")}</span></span>
+<span id="cb19-208"><a href="#cb19-208"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb19-209"><a href="#cb19-209"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb19-210"><a href="#cb19-210"></a></span>
+<span id="cb19-211"><a href="#cb19-211"></a>adlb_v <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb19-212"><a href="#cb19-212"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">&amp;</span></span>
+<span id="cb19-213"><a href="#cb19-213"></a>    AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>))</span>
+<span id="cb19-214"><a href="#cb19-214"></a></span>
+<span id="cb19-215"><a href="#cb19-215"></a>bp_7 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_v, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-216"><a href="#cb19-216"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">position =</span> <span class="fu">position_dodge2</span>(.<span class="dv">5</span>), <span class="fu">aes</span>(<span class="at">fill =</span> ARMCD, <span class="at">color =</span> ARMCD)) <span class="sc">+</span></span>
+<span id="cb19-217"><a href="#cb19-217"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="fu">aes</span>(<span class="at">group =</span> ARMCD), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb19-218"><a href="#cb19-218"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-219"><a href="#cb19-219"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-220"><a href="#cb19-220"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb19-221"><a href="#cb19-221"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb19-222"><a href="#cb19-222"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-223"><a href="#cb19-223"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-224"><a href="#cb19-224"></a>  theme_bp</span>
+<span id="cb19-225"><a href="#cb19-225"></a></span>
+<span id="cb19-226"><a href="#cb19-226"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_7, oc, <span class="dv">2</span>)</span>
+<span id="cb19-227"><a href="#cb19-227"></a>plot</span>
+<span id="cb19-228"><a href="#cb19-228"></a><span class="in">```</span></span>
+<span id="cb19-229"><a href="#cb19-229"></a></span>
+<span id="cb19-230"><a href="#cb19-230"></a><span class="fu">## Plot by Timepoint &lt;br/&gt; and Treatment</span></span>
+<span id="cb19-231"><a href="#cb19-231"></a></span>
+<span id="cb19-232"><a href="#cb19-232"></a><span class="in">```{r plot7, test = list(plot_v7 = "plot")}</span></span>
+<span id="cb19-233"><a href="#cb19-233"></a>bp_8 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_v, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-234"><a href="#cb19-234"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="at">width =</span> .<span class="dv">5</span>), <span class="fu">aes</span>(<span class="at">fill =</span> AVISIT, <span class="at">color =</span> AVISIT)) <span class="sc">+</span></span>
+<span id="cb19-235"><a href="#cb19-235"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="fu">aes</span>(<span class="at">group =</span> AVISIT), <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge2</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb19-236"><a href="#cb19-236"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-237"><a href="#cb19-237"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-238"><a href="#cb19-238"></a>    <span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>,</span>
+<span id="cb19-239"><a href="#cb19-239"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-240"><a href="#cb19-240"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-241"><a href="#cb19-241"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-242"><a href="#cb19-242"></a>  theme_bp</span>
+<span id="cb19-243"><a href="#cb19-243"></a></span>
+<span id="cb19-244"><a href="#cb19-244"></a>plot <span class="ot">&lt;-</span> <span class="fu">bp_annos</span>(bp_8, oc, <span class="dv">2</span>)</span>
+<span id="cb19-245"><a href="#cb19-245"></a>plot</span>
+<span id="cb19-246"><a href="#cb19-246"></a><span class="in">```</span></span>
+<span id="cb19-247"><a href="#cb19-247"></a></span>
+<span id="cb19-248"><a href="#cb19-248"></a><span class="fu">## Plot with &lt;br/&gt; Table Section</span></span>
+<span id="cb19-249"><a href="#cb19-249"></a></span>
+<span id="cb19-250"><a href="#cb19-250"></a><span class="in">```{r plot8, test = list(plot_v8 = "plot")}</span></span>
+<span id="cb19-251"><a href="#cb19-251"></a><span class="co"># Make wide dataset with summary statistics</span></span>
+<span id="cb19-252"><a href="#cb19-252"></a>adlb_wide <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb19-253"><a href="#cb19-253"></a>  <span class="fu">group_by</span>(ARMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb19-254"><a href="#cb19-254"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb19-255"><a href="#cb19-255"></a>    <span class="at">n =</span> <span class="fu">n</span>(),</span>
+<span id="cb19-256"><a href="#cb19-256"></a>    <span class="at">mean =</span> <span class="fu">round</span>(<span class="fu">mean</span>(AVAL), <span class="dv">1</span>),</span>
+<span id="cb19-257"><a href="#cb19-257"></a>    <span class="at">median =</span> <span class="fu">round</span>(<span class="fu">median</span>(AVAL), <span class="dv">1</span>),</span>
+<span id="cb19-258"><a href="#cb19-258"></a>    <span class="at">median_ci =</span> <span class="fu">paste</span>(<span class="fu">round</span>(DescTools<span class="sc">::</span><span class="fu">MedianCI</span>(AVAL)[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>], <span class="dv">1</span>), <span class="at">collapse =</span> <span class="st">" - "</span>),</span>
+<span id="cb19-259"><a href="#cb19-259"></a>    <span class="at">q1_q3 =</span> <span class="fu">paste</span>(<span class="fu">round</span>(<span class="fu">quantile</span>(AVAL, <span class="fu">c</span>(<span class="fl">0.25</span>, <span class="fl">0.75</span>)), <span class="dv">1</span>), <span class="at">collapse =</span> <span class="st">" - "</span>),</span>
+<span id="cb19-260"><a href="#cb19-260"></a>    <span class="at">min_max =</span> <span class="fu">paste0</span>(<span class="fu">round</span>(<span class="fu">min</span>(AVAL), <span class="dv">1</span>), <span class="st">"-"</span>, <span class="fu">max</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>)))</span>
+<span id="cb19-261"><a href="#cb19-261"></a>  )</span>
+<span id="cb19-262"><a href="#cb19-262"></a></span>
+<span id="cb19-263"><a href="#cb19-263"></a><span class="co"># Make long dataset</span></span>
+<span id="cb19-264"><a href="#cb19-264"></a>adlb_long <span class="ot">&lt;-</span> tidyr<span class="sc">::</span><span class="fu">gather</span>(adlb_wide, <span class="at">key =</span> type, <span class="at">value =</span> stat, n<span class="sc">:</span>min_max)</span>
+<span id="cb19-265"><a href="#cb19-265"></a>adlb_long <span class="ot">&lt;-</span> adlb_long <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb19-266"><a href="#cb19-266"></a>  <span class="at">type_lbl =</span> <span class="fu">case_when</span>(</span>
+<span id="cb19-267"><a href="#cb19-267"></a>    type <span class="sc">==</span> <span class="st">"n"</span> <span class="sc">~</span> <span class="st">"n"</span>,</span>
+<span id="cb19-268"><a href="#cb19-268"></a>    type <span class="sc">==</span> <span class="st">"mean"</span> <span class="sc">~</span> <span class="st">"Mean"</span>,</span>
+<span id="cb19-269"><a href="#cb19-269"></a>    type <span class="sc">==</span> <span class="st">"median"</span> <span class="sc">~</span> <span class="st">"Median"</span>,</span>
+<span id="cb19-270"><a href="#cb19-270"></a>    type <span class="sc">==</span> <span class="st">"median_ci"</span> <span class="sc">~</span> <span class="st">"95% CI for Median"</span>,</span>
+<span id="cb19-271"><a href="#cb19-271"></a>    type <span class="sc">==</span> <span class="st">"q1_q3"</span> <span class="sc">~</span> <span class="st">"25% and 75%-ile"</span>,</span>
+<span id="cb19-272"><a href="#cb19-272"></a>    type <span class="sc">==</span> <span class="st">"min_max"</span> <span class="sc">~</span> <span class="st">"Min - Max"</span></span>
+<span id="cb19-273"><a href="#cb19-273"></a>  )</span>
+<span id="cb19-274"><a href="#cb19-274"></a>)</span>
+<span id="cb19-275"><a href="#cb19-275"></a>adlb_long<span class="sc">$</span>type_lbl <span class="ot">&lt;-</span> <span class="fu">factor</span>(adlb_long<span class="sc">$</span>type_lbl,</span>
+<span id="cb19-276"><a href="#cb19-276"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Min - Max"</span>, <span class="st">"25% and 75%-ile"</span>, <span class="st">"95% CI for Median"</span>, <span class="st">"Median"</span>, <span class="st">"Mean"</span>, <span class="st">"n"</span>)</span>
+<span id="cb19-277"><a href="#cb19-277"></a>)</span>
+<span id="cb19-278"><a href="#cb19-278"></a></span>
+<span id="cb19-279"><a href="#cb19-279"></a>bp_9 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL)) <span class="sc">+</span></span>
+<span id="cb19-280"><a href="#cb19-280"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"boxplot"</span>, <span class="at">fun.data =</span> five_num, <span class="at">fill =</span> fc, <span class="at">color =</span> oc) <span class="sc">+</span></span>
+<span id="cb19-281"><a href="#cb19-281"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> mean, <span class="at">size =</span> <span class="dv">3</span>, <span class="at">shape =</span> <span class="dv">8</span>) <span class="sc">+</span></span>
+<span id="cb19-282"><a href="#cb19-282"></a>  <span class="fu">labs</span>(</span>
+<span id="cb19-283"><a href="#cb19-283"></a>    <span class="at">title =</span> <span class="st">"Box Plot of Laboratory Test Results"</span>,</span>
+<span id="cb19-284"><a href="#cb19-284"></a>    <span class="at">subtitle =</span> <span class="fu">paste</span>(<span class="st">"Visit:"</span>, adlb<span class="sc">$</span>AVISIT[<span class="dv">1</span>]),</span>
+<span id="cb19-285"><a href="#cb19-285"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb19-286"><a href="#cb19-286"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb19-287"><a href="#cb19-287"></a>  ) <span class="sc">+</span></span>
+<span id="cb19-288"><a href="#cb19-288"></a>  theme_bp</span>
+<span id="cb19-289"><a href="#cb19-289"></a></span>
+<span id="cb19-290"><a href="#cb19-290"></a>tbl_theme <span class="ot">&lt;-</span> <span class="fu">theme</span>(</span>
+<span id="cb19-291"><a href="#cb19-291"></a>  <span class="at">panel.border =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb19-292"><a href="#cb19-292"></a>  <span class="at">panel.grid.major =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb19-293"><a href="#cb19-293"></a>  <span class="at">panel.grid.minor =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb19-294"><a href="#cb19-294"></a>  <span class="at">axis.ticks =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb19-295"><a href="#cb19-295"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>(),</span>
+<span id="cb19-296"><a href="#cb19-296"></a>  <span class="at">axis.text.y =</span> <span class="fu">element_text</span>(<span class="at">face =</span> <span class="st">"plain"</span>),</span>
+<span id="cb19-297"><a href="#cb19-297"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb19-298"><a href="#cb19-298"></a>)</span>
+<span id="cb19-299"><a href="#cb19-299"></a></span>
+<span id="cb19-300"><a href="#cb19-300"></a>tbl_1 <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adlb_long, <span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> type_lbl, <span class="at">label =</span> stat), <span class="at">vjust =</span> <span class="dv">10</span>) <span class="sc">+</span></span>
+<span id="cb19-301"><a href="#cb19-301"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb19-302"><a href="#cb19-302"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="fu">levels</span>(adlb_long<span class="sc">$</span>type_lbl)) <span class="sc">+</span></span>
+<span id="cb19-303"><a href="#cb19-303"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb19-304"><a href="#cb19-304"></a>  tbl_theme <span class="sc">+</span></span>
+<span id="cb19-305"><a href="#cb19-305"></a>  <span class="fu">labs</span>(<span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>) <span class="sc">+</span></span>
+<span id="cb19-306"><a href="#cb19-306"></a>  theme_bp</span>
+<span id="cb19-307"><a href="#cb19-307"></a></span>
+<span id="cb19-308"><a href="#cb19-308"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(<span class="fu">bp_annos</span>(bp_9, oc), tbl_1,</span>
+<span id="cb19-309"><a href="#cb19-309"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">4</span>, <span class="dv">2</span>),</span>
+<span id="cb19-310"><a href="#cb19-310"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb19-311"><a href="#cb19-311"></a>)</span>
+<span id="cb19-312"><a href="#cb19-312"></a>plot</span>
+<span id="cb19-313"><a href="#cb19-313"></a><span class="in">```</span></span>
+<span id="cb19-314"><a href="#cb19-314"></a></span>
+<span id="cb19-315"><a href="#cb19-315"></a><span class="fu">## Plot with Number of Patients &lt;br/&gt; only in Table Section</span></span>
+<span id="cb19-316"><a href="#cb19-316"></a></span>
+<span id="cb19-317"><a href="#cb19-317"></a><span class="in">```{r plot9, test = list(plot_v9 = "plot")}</span></span>
+<span id="cb19-318"><a href="#cb19-318"></a>tbl_2 <span class="ot">&lt;-</span> adlb_long <span class="sc">%&gt;%</span></span>
+<span id="cb19-319"><a href="#cb19-319"></a>  <span class="fu">filter</span>(type <span class="sc">==</span> <span class="st">"n"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb19-320"><a href="#cb19-320"></a>  <span class="fu">ggplot</span>(<span class="fu">aes</span>(<span class="at">x =</span> ARMCD, <span class="at">y =</span> type_lbl, <span class="at">label =</span> stat)) <span class="sc">+</span></span>
+<span id="cb19-321"><a href="#cb19-321"></a>  <span class="fu">geom_text</span>(<span class="at">size =</span> <span class="dv">3</span>) <span class="sc">+</span></span>
+<span id="cb19-322"><a href="#cb19-322"></a>  <span class="fu">scale_y_discrete</span>(<span class="at">labels =</span> <span class="st">"n"</span>) <span class="sc">+</span></span>
+<span id="cb19-323"><a href="#cb19-323"></a>  <span class="fu">theme_bw</span>() <span class="sc">+</span></span>
+<span id="cb19-324"><a href="#cb19-324"></a>  tbl_theme <span class="sc">+</span></span>
+<span id="cb19-325"><a href="#cb19-325"></a>  <span class="fu">labs</span>(<span class="at">caption =</span> <span class="st">"The whiskers extend to the minimum and maximum values."</span>) <span class="sc">+</span></span>
+<span id="cb19-326"><a href="#cb19-326"></a>  theme_bp</span>
+<span id="cb19-327"><a href="#cb19-327"></a></span>
+<span id="cb19-328"><a href="#cb19-328"></a>plot <span class="ot">&lt;-</span> ggpubr<span class="sc">::</span><span class="fu">ggarrange</span>(<span class="fu">bp_annos</span>(bp_9, oc), tbl_2,</span>
+<span id="cb19-329"><a href="#cb19-329"></a>  <span class="at">heights =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">1</span>),</span>
+<span id="cb19-330"><a href="#cb19-330"></a>  <span class="at">ncol =</span> <span class="dv">1</span>, <span class="at">nrow =</span> <span class="dv">2</span>, <span class="at">align =</span> <span class="st">"v"</span></span>
+<span id="cb19-331"><a href="#cb19-331"></a>)</span>
+<span id="cb19-332"><a href="#cb19-332"></a>plot</span>
+<span id="cb19-333"><a href="#cb19-333"></a><span class="in">```</span></span>
+<span id="cb19-334"><a href="#cb19-334"></a></span>
+<span id="cb19-335"><a href="#cb19-335"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb19-336"><a href="#cb19-336"></a></span>
+<span id="cb19-337"><a href="#cb19-337"></a><span class="fu">## `teal` App</span></span>
+<span id="cb19-338"><a href="#cb19-338"></a></span>
+<span id="cb19-339"><a href="#cb19-339"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb19-340"><a href="#cb19-340"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb19-341"><a href="#cb19-341"></a></span>
+<span id="cb19-342"><a href="#cb19-342"></a><span class="fu">library</span>(scda)</span>
+<span id="cb19-343"><a href="#cb19-343"></a><span class="fu">library</span>(teal.modules.general)</span>
+<span id="cb19-344"><a href="#cb19-344"></a></span>
+<span id="cb19-345"><a href="#cb19-345"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb19-346"><a href="#cb19-346"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb19-347"><a href="#cb19-347"></a></span>
+<span id="cb19-348"><a href="#cb19-348"></a><span class="co"># If PARAMCD and AVISIT are not factors, convert to factors</span></span>
+<span id="cb19-349"><a href="#cb19-349"></a><span class="co"># Also fill in missing values with "&lt;Missing&gt;"</span></span>
+<span id="cb19-350"><a href="#cb19-350"></a>ADLB <span class="ot">&lt;-</span> ADLB <span class="sc">%&gt;%</span></span>
+<span id="cb19-351"><a href="#cb19-351"></a>  tern<span class="sc">::</span><span class="fu">df_explicit_na</span>(</span>
+<span id="cb19-352"><a href="#cb19-352"></a>    <span class="at">omit_columns =</span> <span class="fu">setdiff</span>(<span class="fu">names</span>(ADLB), <span class="fu">c</span>(<span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb19-353"><a href="#cb19-353"></a>    <span class="at">char_as_factor =</span> <span class="cn">TRUE</span></span>
+<span id="cb19-354"><a href="#cb19-354"></a>  )</span>
+<span id="cb19-355"><a href="#cb19-355"></a></span>
+<span id="cb19-356"><a href="#cb19-356"></a><span class="co"># If statment below fails, pre-process ADLB to be one record per</span></span>
+<span id="cb19-357"><a href="#cb19-357"></a><span class="co"># study, subject, param and visit eg. filter with ANLFL = 'Y'</span></span>
+<span id="cb19-358"><a href="#cb19-358"></a><span class="fu">stopifnot</span>(<span class="fu">nrow</span>(ADLB) <span class="sc">==</span> <span class="fu">nrow</span>(<span class="fu">unique</span>(ADLB[, <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)])))</span>
+<span id="cb19-359"><a href="#cb19-359"></a></span>
+<span id="cb19-360"><a href="#cb19-360"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb19-361"><a href="#cb19-361"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb19-362"><a href="#cb19-362"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb19-363"><a href="#cb19-363"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>, <span class="st">"AVISIT"</span>)), <span class="co"># do not modify</span></span>
+<span id="cb19-364"><a href="#cb19-364"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb19-365"><a href="#cb19-365"></a><span class="st">    ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")</span></span>
+<span id="cb19-366"><a href="#cb19-366"></a><span class="st">    ADLB &lt;- ADLB %&gt;%</span></span>
+<span id="cb19-367"><a href="#cb19-367"></a><span class="st">      tern::df_explicit_na(</span></span>
+<span id="cb19-368"><a href="#cb19-368"></a><span class="st">        omit_columns = setdiff(names(ADLB), c("PARAMCD", "AVISIT")),</span></span>
+<span id="cb19-369"><a href="#cb19-369"></a><span class="st">        char_as_factor = TRUE)'</span></span>
+<span id="cb19-370"><a href="#cb19-370"></a>  ),</span>
+<span id="cb19-371"><a href="#cb19-371"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb19-372"><a href="#cb19-372"></a>    <span class="fu">tm_g_bivariate</span>(</span>
+<span id="cb19-373"><a href="#cb19-373"></a>      <span class="at">x =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb19-374"><a href="#cb19-374"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb19-375"><a href="#cb19-375"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb19-376"><a href="#cb19-376"></a>          <span class="at">label =</span> <span class="st">"Select variable:"</span>,</span>
+<span id="cb19-377"><a href="#cb19-377"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADSL),</span>
+<span id="cb19-378"><a href="#cb19-378"></a>          <span class="at">selected =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb19-379"><a href="#cb19-379"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb19-380"><a href="#cb19-380"></a>        )</span>
+<span id="cb19-381"><a href="#cb19-381"></a>      ),</span>
+<span id="cb19-382"><a href="#cb19-382"></a>      <span class="at">y =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb19-383"><a href="#cb19-383"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb19-384"><a href="#cb19-384"></a>        <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb19-385"><a href="#cb19-385"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb19-386"><a href="#cb19-386"></a>            <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"PARAMCD"</span>),</span>
+<span id="cb19-387"><a href="#cb19-387"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD),</span>
+<span id="cb19-388"><a href="#cb19-388"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>],</span>
+<span id="cb19-389"><a href="#cb19-389"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-390"><a href="#cb19-390"></a>            <span class="at">label =</span> <span class="st">"Choose lab parameter"</span></span>
+<span id="cb19-391"><a href="#cb19-391"></a>          ),</span>
+<span id="cb19-392"><a href="#cb19-392"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb19-393"><a href="#cb19-393"></a>            <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>),</span>
+<span id="cb19-394"><a href="#cb19-394"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT),</span>
+<span id="cb19-395"><a href="#cb19-395"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT)[<span class="dv">1</span>],</span>
+<span id="cb19-396"><a href="#cb19-396"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-397"><a href="#cb19-397"></a>            <span class="at">label =</span> <span class="st">"Choose visit"</span></span>
+<span id="cb19-398"><a href="#cb19-398"></a>          )</span>
+<span id="cb19-399"><a href="#cb19-399"></a>        ),</span>
+<span id="cb19-400"><a href="#cb19-400"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb19-401"><a href="#cb19-401"></a>          <span class="at">label =</span> <span class="st">"Select variable:"</span>,</span>
+<span id="cb19-402"><a href="#cb19-402"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb19-403"><a href="#cb19-403"></a>          <span class="at">selected =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb19-404"><a href="#cb19-404"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-405"><a href="#cb19-405"></a>          <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb19-406"><a href="#cb19-406"></a>        )</span>
+<span id="cb19-407"><a href="#cb19-407"></a>      ),</span>
+<span id="cb19-408"><a href="#cb19-408"></a>      <span class="at">row_facet =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb19-409"><a href="#cb19-409"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb19-410"><a href="#cb19-410"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb19-411"><a href="#cb19-411"></a>          <span class="at">label =</span> <span class="st">"Select variables:"</span>,</span>
+<span id="cb19-412"><a href="#cb19-412"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb19-413"><a href="#cb19-413"></a>          <span class="at">selected =</span> <span class="cn">NULL</span>,</span>
+<span id="cb19-414"><a href="#cb19-414"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-415"><a href="#cb19-415"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb19-416"><a href="#cb19-416"></a>        )</span>
+<span id="cb19-417"><a href="#cb19-417"></a>      ),</span>
+<span id="cb19-418"><a href="#cb19-418"></a>      <span class="at">col_facet =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb19-419"><a href="#cb19-419"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb19-420"><a href="#cb19-420"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb19-421"><a href="#cb19-421"></a>          <span class="at">label =</span> <span class="st">"Select variables:"</span>,</span>
+<span id="cb19-422"><a href="#cb19-422"></a>          <span class="at">choices =</span> <span class="fu">names</span>(ADLB),</span>
+<span id="cb19-423"><a href="#cb19-423"></a>          <span class="at">selected =</span> <span class="cn">NULL</span>,</span>
+<span id="cb19-424"><a href="#cb19-424"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-425"><a href="#cb19-425"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb19-426"><a href="#cb19-426"></a>        )</span>
+<span id="cb19-427"><a href="#cb19-427"></a>      )</span>
+<span id="cb19-428"><a href="#cb19-428"></a>    )</span>
+<span id="cb19-429"><a href="#cb19-429"></a>  )</span>
+<span id="cb19-430"><a href="#cb19-430"></a>)</span>
+<span id="cb19-431"><a href="#cb19-431"></a></span>
+<span id="cb19-432"><a href="#cb19-432"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb19-433"><a href="#cb19-433"></a><span class="in">```</span></span>
+<span id="cb19-434"><a href="#cb19-434"></a></span>
+<span id="cb19-435"><a href="#cb19-435"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb19-436"><a href="#cb19-436"></a></span>
+<span id="cb19-437"><a href="#cb19-437"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
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+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
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+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">PKPG06</span></a>
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+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CIG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Confidence Interval Plot</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of Mean and <br> 95% CIs for Mean</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot of Confidence Interval Using <br> a Different Stratification Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot of Median and <br> 95% CIs for Median</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot of Median and 95% CIs for <br> Median Using Different Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table of Mean <br> and Median</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cig01_cache/html/setup_c1ca01b49cb321b747b63b2500579a1a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>, AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The function <code>stat_mean_ci</code> from the <code>tern</code> package can be used with default values to draw the 95% confidence interval around the mean.</p>
+<div class="cell" data-test="{&quot;plot_v1_and_v2&quot;:&quot;plot&quot;}" data-hash="cig01_cache/html/plot1and2_6e82d8553cdeb2c366cb2548b197cab4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> SEX,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">lty =</span> SEX, <span class="at">shape =</span> SEX</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  )</span>
+<span id="cb2-7"><a href="#cb2-7"></a>) <span class="sc">+</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">labs</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">caption =</span> <span class="st">"Mean and 95% CIs for mean are displayed."</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb2-24"><a href="#cb2-24"></a>  )</span>
+<span id="cb2-25"><a href="#cb2-25"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cig01_files/figure-html/plot1and2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="cig01_cache/html/plot3_9ab32a5b7201e4a369c6e09f427c70ca">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> STRATA2,</span>
+<span id="cb3-5"><a href="#cb3-5"></a>    <span class="at">lty =</span> STRATA2, <span class="at">shape =</span> STRATA2</span>
+<span id="cb3-6"><a href="#cb3-6"></a>  )</span>
+<span id="cb3-7"><a href="#cb3-7"></a>) <span class="sc">+</span></span>
+<span id="cb3-8"><a href="#cb3-8"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb3-9"><a href="#cb3-9"></a>    <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci,</span>
+<span id="cb3-10"><a href="#cb3-10"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb3-13"><a href="#cb3-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-14"><a href="#cb3-14"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb3-16"><a href="#cb3-16"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb3-17"><a href="#cb3-17"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb3-18"><a href="#cb3-18"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-19"><a href="#cb3-19"></a>  <span class="fu">labs</span>(</span>
+<span id="cb3-20"><a href="#cb3-20"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb3-21"><a href="#cb3-21"></a>    <span class="at">caption =</span> <span class="st">"Mean and 95% CIs for mean are displayed."</span>,</span>
+<span id="cb3-22"><a href="#cb3-22"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb3-23"><a href="#cb3-23"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb3-24"><a href="#cb3-24"></a>  )</span>
+<span id="cb3-25"><a href="#cb3-25"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cig01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The function <code>stat_median_ci</code> from the <code>tern</code> package works similarly to <code>stat_mean_ci</code>.</p>
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="cig01_cache/html/plot4_84663a75a90139e0d24c7776907f885d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> STRATA1,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">lty =</span> STRATA1, <span class="at">shape =</span> STRATA1</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  )</span>
+<span id="cb4-7"><a href="#cb4-7"></a>) <span class="sc">+</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">fun.data =</span> stat_median_ci,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">fun =</span> median,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  ) <span class="sc">+</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="fu">labs</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">caption =</span> <span class="st">"Median and 95% CIs for median are displayed."</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb4-24"><a href="#cb4-24"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>To modify the confidence level for the estimation of the confidence interval, the call to <code>stat_mean_ci</code> (or <code>stat_median_ci</code>) can be slightly modified.</p>
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="cig01_cache/html/plot5_039752477baa9df59989d5622ad65eb0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb5-4"><a href="#cb5-4"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> SEX,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>    <span class="at">lty =</span> SEX, <span class="at">shape =</span> SEX</span>
+<span id="cb5-6"><a href="#cb5-6"></a>  )</span>
+<span id="cb5-7"><a href="#cb5-7"></a>) <span class="sc">+</span></span>
+<span id="cb5-8"><a href="#cb5-8"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb5-9"><a href="#cb5-9"></a>    <span class="at">fun.data =</span> <span class="cf">function</span>(x) tern<span class="sc">::</span><span class="fu">stat_mean_ci</span>(x, <span class="at">conf_level =</span> <span class="fl">0.9</span>),</span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb5-13"><a href="#cb5-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb5-15"><a href="#cb5-15"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb5-16"><a href="#cb5-16"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb5-17"><a href="#cb5-17"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb5-18"><a href="#cb5-18"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-19"><a href="#cb5-19"></a>  <span class="fu">labs</span>(</span>
+<span id="cb5-20"><a href="#cb5-20"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb5-21"><a href="#cb5-21"></a>    <span class="at">caption =</span> <span class="st">"Mean and 90% CIs for mean are displayed."</span>,</span>
+<span id="cb5-22"><a href="#cb5-22"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb5-23"><a href="#cb5-23"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb5-24"><a href="#cb5-24"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>The corresponding table is simply obtained using the <code>rtables</code> framework:</p>
+<div class="cell" data-test="{&quot;table_v6&quot;:&quot;table&quot;}" data-hash="cig01_cache/html/table6_3a9c1d1254738429e2bcbfc3a2cdc2a4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"mean_sd"</span>, <span class="st">"median"</span>))</span>
+<span id="cb6-4"><a href="#cb6-4"></a>table <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb)</span>
+<span id="cb6-5"><a href="#cb6-5"></a>table</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>              ARM A        ARM B        ARM C   
+————————————————————————————————————————————————
+Mean (SD)   17.7 (9.9)   18.7 (9.8)   19.5 (9.1)
+Median         17.5         18.2         19.0   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="cig01_cache/html/teal_0603d208941b73f0512cee06d9d09535">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-5"><a href="#cb8-5"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB),</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a><span class="st">    ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  ),</span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="fu">tm_g_ci</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>      <span class="at">label =</span> <span class="st">"Confidence Interval Plot"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>      <span class="at">x_var =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb8-20"><a href="#cb8-20"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"ARMCD"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>          <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb8-22"><a href="#cb8-22"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-23"><a href="#cb8-23"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>        )</span>
+<span id="cb8-25"><a href="#cb8-25"></a>      ),</span>
+<span id="cb8-26"><a href="#cb8-26"></a>      <span class="at">y_var =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb8-27"><a href="#cb8-27"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>        <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb8-29"><a href="#cb8-29"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>            <span class="at">vars =</span> <span class="st">"PARAMCD"</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>],</span>
+<span id="cb8-33"><a href="#cb8-33"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>            <span class="at">label =</span> <span class="st">"Select lab:"</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>          ),</span>
+<span id="cb8-36"><a href="#cb8-36"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>            <span class="at">vars =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT)[<span class="dv">1</span>],</span>
+<span id="cb8-40"><a href="#cb8-40"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>            <span class="at">label =</span> <span class="st">"Select visit:"</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>          )</span>
+<span id="cb8-43"><a href="#cb8-43"></a>        ),</span>
+<span id="cb8-44"><a href="#cb8-44"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>          <span class="at">label =</span> <span class="st">"Analyzed Value"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>          <span class="at">selected =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a>        )</span>
+<span id="cb8-51"><a href="#cb8-51"></a>      ),</span>
+<span id="cb8-52"><a href="#cb8-52"></a>      <span class="at">color =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb8-53"><a href="#cb8-53"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>          <span class="at">label =</span> <span class="st">"Color by variable"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>          <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"STRATA1"</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>        )</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      )</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    )</span>
+<span id="cb8-63"><a href="#cb8-63"></a>  ),</span>
+<span id="cb8-64"><a href="#cb8-64"></a>  <span class="at">header =</span> <span class="st">"Example of Confidence Interval Plot"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="at">footer =</span> tags<span class="sc">$</span><span class="fu">p</span>(</span>
+<span id="cb8-66"><a href="#cb8-66"></a>    <span class="at">class =</span> <span class="st">"text-muted"</span>, <span class="st">"Source: `teal.modules.clinical::tm_g_ci`"</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a>  )</span>
+<span id="cb8-68"><a href="#cb8-68"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:53:06.4337 pid:6516 token:[] teal.modules.clinical Initializing tm_g_ci</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cig01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cig01_cache/html/sessioninfo_e950967d2888d96e57dfdafa79f4d231">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              scda_0.1.6                  
+ [9] dplyr_1.1.3                  ggplot2_3.4.3               
+[11] tern_0.9.0                   rtables_0.6.3               
+[13] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        
+ [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        
+ [7] digest_0.6.33         estimability_1.4.1    mime_0.12            
+[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       
+[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       
+[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          
+[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           
+[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      
+[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   
+[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          
+[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       
+[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         
+[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          
+[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       
+[49] jsonlite_1.8.7        callr_3.7.3           teal.widgets_0.4.0   
+[52] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      
+[55] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             
+[58] codetools_0.2-19      gtable_0.3.4          later_1.3.1          
+[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         
+[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      
+[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           
+[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cig01_cache/html/snapshot_3aac405cc3c468941a4e7c1cf18f8500">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/cig01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> CIG01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Confidence Interval Plot</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-20"><a href="#cb14-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb14-21"><a href="#cb14-21"></a></span>
+<span id="cb14-22"><a href="#cb14-22"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-23"><a href="#cb14-23"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>, AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>)</span>
+<span id="cb14-24"><a href="#cb14-24"></a><span class="in">```</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a></span>
+<span id="cb14-26"><a href="#cb14-26"></a><span class="fu">## Plot of Mean and &lt;br/&gt; 95% CIs for Mean</span></span>
+<span id="cb14-27"><a href="#cb14-27"></a></span>
+<span id="cb14-28"><a href="#cb14-28"></a>The function <span class="in">`stat_mean_ci`</span> from the <span class="in">`tern`</span> package can be used with default values to draw the 95% confidence interval around the mean.</span>
+<span id="cb14-29"><a href="#cb14-29"></a></span>
+<span id="cb14-30"><a href="#cb14-30"></a><span class="in">```{r plot1and2, test = list(plot_v1_and_v2 = "plot")}</span></span>
+<span id="cb14-31"><a href="#cb14-31"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb14-32"><a href="#cb14-32"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-33"><a href="#cb14-33"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb14-34"><a href="#cb14-34"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> SEX,</span>
+<span id="cb14-35"><a href="#cb14-35"></a>    <span class="at">lty =</span> SEX, <span class="at">shape =</span> SEX</span>
+<span id="cb14-36"><a href="#cb14-36"></a>  )</span>
+<span id="cb14-37"><a href="#cb14-37"></a>) <span class="sc">+</span></span>
+<span id="cb14-38"><a href="#cb14-38"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-39"><a href="#cb14-39"></a>    <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci,</span>
+<span id="cb14-40"><a href="#cb14-40"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-41"><a href="#cb14-41"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb14-42"><a href="#cb14-42"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-43"><a href="#cb14-43"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-44"><a href="#cb14-44"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-45"><a href="#cb14-45"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb14-46"><a href="#cb14-46"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb14-47"><a href="#cb14-47"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-48"><a href="#cb14-48"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-49"><a href="#cb14-49"></a>  <span class="fu">labs</span>(</span>
+<span id="cb14-50"><a href="#cb14-50"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb14-51"><a href="#cb14-51"></a>    <span class="at">caption =</span> <span class="st">"Mean and 95% CIs for mean are displayed."</span>,</span>
+<span id="cb14-52"><a href="#cb14-52"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb14-53"><a href="#cb14-53"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb14-54"><a href="#cb14-54"></a>  )</span>
+<span id="cb14-55"><a href="#cb14-55"></a>plot</span>
+<span id="cb14-56"><a href="#cb14-56"></a><span class="in">```</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a></span>
+<span id="cb14-58"><a href="#cb14-58"></a><span class="fu">## Plot of Confidence Interval Using &lt;br/&gt; a Different Stratification Variable</span></span>
+<span id="cb14-59"><a href="#cb14-59"></a></span>
+<span id="cb14-60"><a href="#cb14-60"></a><span class="in">```{r plot3, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb14-61"><a href="#cb14-61"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb14-62"><a href="#cb14-62"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-63"><a href="#cb14-63"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb14-64"><a href="#cb14-64"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> STRATA2,</span>
+<span id="cb14-65"><a href="#cb14-65"></a>    <span class="at">lty =</span> STRATA2, <span class="at">shape =</span> STRATA2</span>
+<span id="cb14-66"><a href="#cb14-66"></a>  )</span>
+<span id="cb14-67"><a href="#cb14-67"></a>) <span class="sc">+</span></span>
+<span id="cb14-68"><a href="#cb14-68"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci,</span>
+<span id="cb14-70"><a href="#cb14-70"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-71"><a href="#cb14-71"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb14-72"><a href="#cb14-72"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-73"><a href="#cb14-73"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-74"><a href="#cb14-74"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb14-76"><a href="#cb14-76"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb14-77"><a href="#cb14-77"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-78"><a href="#cb14-78"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-79"><a href="#cb14-79"></a>  <span class="fu">labs</span>(</span>
+<span id="cb14-80"><a href="#cb14-80"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb14-81"><a href="#cb14-81"></a>    <span class="at">caption =</span> <span class="st">"Mean and 95% CIs for mean are displayed."</span>,</span>
+<span id="cb14-82"><a href="#cb14-82"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb14-83"><a href="#cb14-83"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb14-84"><a href="#cb14-84"></a>  )</span>
+<span id="cb14-85"><a href="#cb14-85"></a>plot</span>
+<span id="cb14-86"><a href="#cb14-86"></a><span class="in">```</span></span>
+<span id="cb14-87"><a href="#cb14-87"></a></span>
+<span id="cb14-88"><a href="#cb14-88"></a><span class="fu">## Plot of Median and &lt;br/&gt; 95% CIs for Median</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a></span>
+<span id="cb14-90"><a href="#cb14-90"></a>The function <span class="in">`stat_median_ci`</span> from the <span class="in">`tern`</span> package works similarly to <span class="in">`stat_mean_ci`</span>.</span>
+<span id="cb14-91"><a href="#cb14-91"></a></span>
+<span id="cb14-92"><a href="#cb14-92"></a><span class="in">```{r plot4, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb14-93"><a href="#cb14-93"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb14-94"><a href="#cb14-94"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-95"><a href="#cb14-95"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb14-96"><a href="#cb14-96"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> STRATA1,</span>
+<span id="cb14-97"><a href="#cb14-97"></a>    <span class="at">lty =</span> STRATA1, <span class="at">shape =</span> STRATA1</span>
+<span id="cb14-98"><a href="#cb14-98"></a>  )</span>
+<span id="cb14-99"><a href="#cb14-99"></a>) <span class="sc">+</span></span>
+<span id="cb14-100"><a href="#cb14-100"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-101"><a href="#cb14-101"></a>    <span class="at">fun.data =</span> stat_median_ci,</span>
+<span id="cb14-102"><a href="#cb14-102"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-103"><a href="#cb14-103"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb14-104"><a href="#cb14-104"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-105"><a href="#cb14-105"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-107"><a href="#cb14-107"></a>    <span class="at">fun =</span> median,</span>
+<span id="cb14-108"><a href="#cb14-108"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-110"><a href="#cb14-110"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-111"><a href="#cb14-111"></a>  <span class="fu">labs</span>(</span>
+<span id="cb14-112"><a href="#cb14-112"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb14-113"><a href="#cb14-113"></a>    <span class="at">caption =</span> <span class="st">"Median and 95% CIs for median are displayed."</span>,</span>
+<span id="cb14-114"><a href="#cb14-114"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb14-115"><a href="#cb14-115"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb14-116"><a href="#cb14-116"></a>  )</span>
+<span id="cb14-117"><a href="#cb14-117"></a><span class="in">```</span></span>
+<span id="cb14-118"><a href="#cb14-118"></a></span>
+<span id="cb14-119"><a href="#cb14-119"></a><span class="fu">## Plot of Median and 95% CIs for &lt;br/&gt; Median Using Different Alpha Level</span></span>
+<span id="cb14-120"><a href="#cb14-120"></a></span>
+<span id="cb14-121"><a href="#cb14-121"></a>To modify the confidence level for the estimation of the confidence interval, the call to <span class="in">`stat_mean_ci`</span> (or <span class="in">`stat_median_ci`</span>) can be slightly modified.</span>
+<span id="cb14-122"><a href="#cb14-122"></a></span>
+<span id="cb14-123"><a href="#cb14-123"></a><span class="in">```{r plot5, test = list(plot_v5 = "plot")}</span></span>
+<span id="cb14-124"><a href="#cb14-124"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(</span>
+<span id="cb14-125"><a href="#cb14-125"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-126"><a href="#cb14-126"></a>  <span class="at">mapping =</span> <span class="fu">aes</span>(</span>
+<span id="cb14-127"><a href="#cb14-127"></a>    <span class="at">x =</span> ARMCD, <span class="at">y =</span> AVAL, <span class="at">color =</span> SEX,</span>
+<span id="cb14-128"><a href="#cb14-128"></a>    <span class="at">lty =</span> SEX, <span class="at">shape =</span> SEX</span>
+<span id="cb14-129"><a href="#cb14-129"></a>  )</span>
+<span id="cb14-130"><a href="#cb14-130"></a>) <span class="sc">+</span></span>
+<span id="cb14-131"><a href="#cb14-131"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-132"><a href="#cb14-132"></a>    <span class="at">fun.data =</span> <span class="cf">function</span>(x) tern<span class="sc">::</span><span class="fu">stat_mean_ci</span>(x, <span class="at">conf_level =</span> <span class="fl">0.9</span>),</span>
+<span id="cb14-133"><a href="#cb14-133"></a>    <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-134"><a href="#cb14-134"></a>    <span class="at">width =</span> <span class="fl">0.1</span>,</span>
+<span id="cb14-135"><a href="#cb14-135"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-136"><a href="#cb14-136"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-137"><a href="#cb14-137"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb14-138"><a href="#cb14-138"></a>    <span class="at">fun =</span> mean,</span>
+<span id="cb14-139"><a href="#cb14-139"></a>    <span class="at">geom =</span> <span class="st">"point"</span>,</span>
+<span id="cb14-140"><a href="#cb14-140"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="fl">0.5</span>)</span>
+<span id="cb14-141"><a href="#cb14-141"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-142"><a href="#cb14-142"></a>  <span class="fu">labs</span>(</span>
+<span id="cb14-143"><a href="#cb14-143"></a>    <span class="at">title =</span> <span class="st">"Confidence Interval Plot by Treatment Group"</span>,</span>
+<span id="cb14-144"><a href="#cb14-144"></a>    <span class="at">caption =</span> <span class="st">"Mean and 90% CIs for mean are displayed."</span>,</span>
+<span id="cb14-145"><a href="#cb14-145"></a>    <span class="at">x =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb14-146"><a href="#cb14-146"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(adlb<span class="sc">$</span>PARAMCD[<span class="dv">1</span>], <span class="st">" ("</span>, adlb<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb14-147"><a href="#cb14-147"></a>  )</span>
+<span id="cb14-148"><a href="#cb14-148"></a><span class="in">```</span></span>
+<span id="cb14-149"><a href="#cb14-149"></a></span>
+<span id="cb14-150"><a href="#cb14-150"></a><span class="fu">## Table of Mean &lt;br/&gt; and Median</span></span>
+<span id="cb14-151"><a href="#cb14-151"></a></span>
+<span id="cb14-152"><a href="#cb14-152"></a>The corresponding table is simply obtained using the <span class="in">`rtables`</span> framework:</span>
+<span id="cb14-153"><a href="#cb14-153"></a></span>
+<span id="cb14-154"><a href="#cb14-154"></a><span class="in">```{r table6, test = list(table_v6 = "table")}</span></span>
+<span id="cb14-155"><a href="#cb14-155"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-156"><a href="#cb14-156"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-157"><a href="#cb14-157"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"mean_sd"</span>, <span class="st">"median"</span>))</span>
+<span id="cb14-158"><a href="#cb14-158"></a>table <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb)</span>
+<span id="cb14-159"><a href="#cb14-159"></a>table</span>
+<span id="cb14-160"><a href="#cb14-160"></a><span class="in">```</span></span>
+<span id="cb14-161"><a href="#cb14-161"></a></span>
+<span id="cb14-162"><a href="#cb14-162"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-163"><a href="#cb14-163"></a></span>
+<span id="cb14-164"><a href="#cb14-164"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-165"><a href="#cb14-165"></a></span>
+<span id="cb14-166"><a href="#cb14-166"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-167"><a href="#cb14-167"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb14-168"><a href="#cb14-168"></a></span>
+<span id="cb14-169"><a href="#cb14-169"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-170"><a href="#cb14-170"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-171"><a href="#cb14-171"></a></span>
+<span id="cb14-172"><a href="#cb14-172"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-173"><a href="#cb14-173"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb14-174"><a href="#cb14-174"></a></span>
+<span id="cb14-175"><a href="#cb14-175"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-176"><a href="#cb14-176"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-177"><a href="#cb14-177"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb14-178"><a href="#cb14-178"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB),</span>
+<span id="cb14-179"><a href="#cb14-179"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb14-180"><a href="#cb14-180"></a><span class="st">    ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb14-181"><a href="#cb14-181"></a>  ),</span>
+<span id="cb14-182"><a href="#cb14-182"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-183"><a href="#cb14-183"></a>    <span class="fu">tm_g_ci</span>(</span>
+<span id="cb14-184"><a href="#cb14-184"></a>      <span class="at">label =</span> <span class="st">"Confidence Interval Plot"</span>,</span>
+<span id="cb14-185"><a href="#cb14-185"></a>      <span class="at">x_var =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb14-186"><a href="#cb14-186"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb14-187"><a href="#cb14-187"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb14-188"><a href="#cb14-188"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"ARMCD"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb14-189"><a href="#cb14-189"></a>          <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb14-190"><a href="#cb14-190"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-191"><a href="#cb14-191"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-192"><a href="#cb14-192"></a>        )</span>
+<span id="cb14-193"><a href="#cb14-193"></a>      ),</span>
+<span id="cb14-194"><a href="#cb14-194"></a>      <span class="at">y_var =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb14-195"><a href="#cb14-195"></a>        <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb14-196"><a href="#cb14-196"></a>        <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb14-197"><a href="#cb14-197"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb14-198"><a href="#cb14-198"></a>            <span class="at">vars =</span> <span class="st">"PARAMCD"</span>,</span>
+<span id="cb14-199"><a href="#cb14-199"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD),</span>
+<span id="cb14-200"><a href="#cb14-200"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>],</span>
+<span id="cb14-201"><a href="#cb14-201"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-202"><a href="#cb14-202"></a>            <span class="at">label =</span> <span class="st">"Select lab:"</span></span>
+<span id="cb14-203"><a href="#cb14-203"></a>          ),</span>
+<span id="cb14-204"><a href="#cb14-204"></a>          <span class="fu">filter_spec</span>(</span>
+<span id="cb14-205"><a href="#cb14-205"></a>            <span class="at">vars =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb14-206"><a href="#cb14-206"></a>            <span class="at">choices =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT),</span>
+<span id="cb14-207"><a href="#cb14-207"></a>            <span class="at">selected =</span> <span class="fu">levels</span>(ADLB<span class="sc">$</span>AVISIT)[<span class="dv">1</span>],</span>
+<span id="cb14-208"><a href="#cb14-208"></a>            <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-209"><a href="#cb14-209"></a>            <span class="at">label =</span> <span class="st">"Select visit:"</span></span>
+<span id="cb14-210"><a href="#cb14-210"></a>          )</span>
+<span id="cb14-211"><a href="#cb14-211"></a>        ),</span>
+<span id="cb14-212"><a href="#cb14-212"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb14-213"><a href="#cb14-213"></a>          <span class="at">label =</span> <span class="st">"Analyzed Value"</span>,</span>
+<span id="cb14-214"><a href="#cb14-214"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb14-215"><a href="#cb14-215"></a>          <span class="at">selected =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-216"><a href="#cb14-216"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-217"><a href="#cb14-217"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-218"><a href="#cb14-218"></a>        )</span>
+<span id="cb14-219"><a href="#cb14-219"></a>      ),</span>
+<span id="cb14-220"><a href="#cb14-220"></a>      <span class="at">color =</span> <span class="fu">data_extract_spec</span>(</span>
+<span id="cb14-221"><a href="#cb14-221"></a>        <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb14-222"><a href="#cb14-222"></a>        <span class="at">select =</span> <span class="fu">select_spec</span>(</span>
+<span id="cb14-223"><a href="#cb14-223"></a>          <span class="at">label =</span> <span class="st">"Color by variable"</span>,</span>
+<span id="cb14-224"><a href="#cb14-224"></a>          <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>),</span>
+<span id="cb14-225"><a href="#cb14-225"></a>          <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"STRATA1"</span>),</span>
+<span id="cb14-226"><a href="#cb14-226"></a>          <span class="at">multiple =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-227"><a href="#cb14-227"></a>          <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-228"><a href="#cb14-228"></a>        )</span>
+<span id="cb14-229"><a href="#cb14-229"></a>      )</span>
+<span id="cb14-230"><a href="#cb14-230"></a>    )</span>
+<span id="cb14-231"><a href="#cb14-231"></a>  ),</span>
+<span id="cb14-232"><a href="#cb14-232"></a>  <span class="at">header =</span> <span class="st">"Example of Confidence Interval Plot"</span>,</span>
+<span id="cb14-233"><a href="#cb14-233"></a>  <span class="at">footer =</span> tags<span class="sc">$</span><span class="fu">p</span>(</span>
+<span id="cb14-234"><a href="#cb14-234"></a>    <span class="at">class =</span> <span class="st">"text-muted"</span>, <span class="st">"Source: `teal.modules.clinical::tm_g_ci`"</span></span>
+<span id="cb14-235"><a href="#cb14-235"></a>  )</span>
+<span id="cb14-236"><a href="#cb14-236"></a>)</span>
+<span id="cb14-237"><a href="#cb14-237"></a></span>
+<span id="cb14-238"><a href="#cb14-238"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-239"><a href="#cb14-239"></a><span class="in">```</span></span>
+<span id="cb14-240"><a href="#cb14-240"></a></span>
+<span id="cb14-241"><a href="#cb14-241"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-242"><a href="#cb14-242"></a></span>
+<span id="cb14-243"><a href="#cb14-243"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/graphs/other/cig01_files/figure-html/plot1and2-1.png b/stable/graphs/other/cig01_files/figure-html/plot1and2-1.png
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new file mode 100644
index 0000000000..3f807f1420
--- /dev/null
+++ b/stable/graphs/other/ippg01.html
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+code.sourceCode > span { color: inherit; text-decoration: inherit; }
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+pre.sourceCode { margin: 0; }
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+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">IPPG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Individual Patient Plot Over Time</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>For illustration purposes, we will subset the <code>adlb</code> dataset for safety population in treatment arm A and a specific lab parameter (<code>ALT</code>).</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Plot</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot with Patient Baselines as Reference</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ippg01_cache/html/setup_fd49cc8e178119de70c6e90615d78171">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># use small sample size</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The user can select different <code>plotting_choices</code> depending on their preference. To demonstrate, separate plots are produced with a maximum of 3 observations each.</p>
+<div class="cell" data-test="{&quot;plots_v1&quot;:&quot;plots&quot;}" data-hash="ippg01_cache/html/plots1_f677fe1c008e98ba9570165c6d7b985b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>plots <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">xvar =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">ylab =</span> <span class="st">"SGOT/ALT (U/L)"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="at">title =</span> <span class="st">"Individual Patient Plots"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">subtitle =</span> <span class="st">"Treatment Arm A"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">plotting_choices =</span> <span class="st">"split_by_max_obs"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="at">max_obs_per_plot =</span> <span class="dv">3</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>plots</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[[1]]</code></pre>
+</div>
+<div class="cell-output-display">
+<p><img src="ippg01_files/figure-html/plots1-1.png" class="img-fluid" width="1440"></p>
+</div>
+<div class="cell-output cell-output-stdout">
+<pre><code>
+[[2]]</code></pre>
+</div>
+<div class="cell-output-display">
+<p><img src="ippg01_files/figure-html/plots1-2.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Here, patients’ individual baseline values will be shown for reference. Note that users can provide their own custom theme to the function via the <code>ggtheme</code> argument.</p>
+<div class="cell" data-test="{&quot;plots_v2&quot;:&quot;plots&quot;}" data-hash="ippg01_cache/html/plots2_88c4a6046d9fca5eaf1c187d1253cac6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plots <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">xvar =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="at">ylab =</span> <span class="st">"SGOT/ALT (U/L)"</span>,</span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb5-8"><a href="#cb5-8"></a>  <span class="at">title =</span> <span class="st">"Individual Patient Plots"</span>,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="at">subtitle =</span> <span class="st">"Treatment Arm A"</span>,</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  <span class="at">add_baseline_hline =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>  <span class="at">yvar_baseline =</span> <span class="st">"BASE"</span>,</span>
+<span id="cb5-12"><a href="#cb5-12"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_minimal</span>(),</span>
+<span id="cb5-13"><a href="#cb5-13"></a>  <span class="at">plotting_choices =</span> <span class="st">"split_by_max_obs"</span>,</span>
+<span id="cb5-14"><a href="#cb5-14"></a>  <span class="at">max_obs_per_plot =</span> <span class="dv">3</span></span>
+<span id="cb5-15"><a href="#cb5-15"></a>)</span>
+<span id="cb5-16"><a href="#cb5-16"></a>plots</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[[1]]</code></pre>
+</div>
+<div class="cell-output-display">
+<p><img src="ippg01_files/figure-html/plots2-1.png" class="img-fluid" width="1440"></p>
+</div>
+<div class="cell-output cell-output-stdout">
+<pre><code>
+[[2]]</code></pre>
+</div>
+<div class="cell-output-display">
+<p><img src="ippg01_files/figure-html/plots2-2.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="ippg01_cache/html/teal_bdf0475a6e1a7ca67be0ec9ce3f6c270">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(teal)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a><span class="co"># use small sample size</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>)</span>
+<span id="cb8-8"><a href="#cb8-8"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-12"><a href="#cb8-12"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb) <span class="sc">%&gt;%</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span>)</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>      adsl,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% slice(1:15)</span></span>
+<span id="cb8-21"><a href="#cb8-21"></a><span class="st">               ADSL &lt;- df_explicit_na(ADSL)'</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>    ),</span>
+<span id="cb8-23"><a href="#cb8-23"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-24"><a href="#cb8-24"></a>      <span class="st">"ADLB"</span>,</span>
+<span id="cb8-25"><a href="#cb8-25"></a>      adlb,</span>
+<span id="cb8-26"><a href="#cb8-26"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;% filter(USUBJID %in% adsl$USUBJID)</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a><span class="st">             ADLB &lt;- df_explicit_na(ADLB) %&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a><span class="st">               dplyr::filter(USUBJID %in% ADSL$USUBJID,</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a><span class="st">                             AVISIT != "SCREENING")'</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>    )</span>
+<span id="cb8-31"><a href="#cb8-31"></a>  ),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-33"><a href="#cb8-33"></a>    <span class="fu">tm_g_ipp</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>      <span class="at">label =</span> <span class="st">"Individual Patient Plot"</span>,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb8-36"><a href="#cb8-36"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>        <span class="fu">value_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"ARMCD"</span>)),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>        <span class="st">"ARM A"</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>      ),</span>
+<span id="cb8-40"><a href="#cb8-40"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb8-42"><a href="#cb8-42"></a>        <span class="st">"ALT"</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>      ),</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>)),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>        <span class="st">"AVAL"</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>      ),</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      <span class="at">avalu_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVALU"</span>)),</span>
+<span id="cb8-50"><a href="#cb8-50"></a>        <span class="st">"AVALU"</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>      ),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"USUBJID"</span>)),</span>
+<span id="cb8-55"><a href="#cb8-55"></a>        <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>      ),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-59"><a href="#cb8-59"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVISIT"</span>)),</span>
+<span id="cb8-60"><a href="#cb8-60"></a>        <span class="st">"AVISIT"</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>      ),</span>
+<span id="cb8-62"><a href="#cb8-62"></a>      <span class="at">base_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-63"><a href="#cb8-63"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"BASE"</span>)),</span>
+<span id="cb8-64"><a href="#cb8-64"></a>        <span class="st">"BASE"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a>      ),</span>
+<span id="cb8-67"><a href="#cb8-67"></a>      <span class="at">add_baseline_hline =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-68"><a href="#cb8-68"></a>      <span class="at">separate_by_obs =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a>    )</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  )</span>
+<span id="cb8-71"><a href="#cb8-71"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:53:35.9124 pid:6627 token:[] teal.modules.clinical Initializing tm_g_ipp</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ippg01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ippg01_cache/html/sessioninfo_d7dac70a6e28c170935a2e58a494a9d8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              ggplot2_3.4.3               
+ [9] dplyr_1.1.3                  scda_0.1.6                  
+[11] tern_0.9.0                   rtables_0.6.3               
+[13] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        
+ [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        
+ [7] digest_0.6.33         estimability_1.4.1    mime_0.12            
+[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       
+[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       
+[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          
+[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           
+[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      
+[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   
+[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          
+[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       
+[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         
+[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          
+[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       
+[49] jsonlite_1.8.7        callr_3.7.3           teal.widgets_0.4.0   
+[52] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      
+[55] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             
+[58] codetools_0.2-19      gtable_0.3.4          later_1.3.1          
+[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         
+[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      
+[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           
+[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[85] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ippg01_cache/html/snapshot_d92b46fae1053bf5a01f4916c6ef3c2b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/ippg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+      }
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/other/cig01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CIG01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/other/kmg01.html" class="pagination-link">
+        <span class="nav-page-text">KMG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> IPPG01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Individual Patient Plot Over Time</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>For illustration purposes, we will subset the <span class="in">`adlb`</span> dataset for safety population in treatment arm A and a specific lab parameter (<span class="in">`ALT`</span>).</span>
+<span id="cb14-11"><a href="#cb14-11"></a></span>
+<span id="cb14-12"><a href="#cb14-12"></a>::: panel-tabset</span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a></span>
+<span id="cb14-15"><a href="#cb14-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-17"><a href="#cb14-17"></a></span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-20"><a href="#cb14-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-21"><a href="#cb14-21"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb14-22"><a href="#cb14-22"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb14-23"><a href="#cb14-23"></a></span>
+<span id="cb14-24"><a href="#cb14-24"></a><span class="co"># use small sample size</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>)</span>
+<span id="cb14-26"><a href="#cb14-26"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb14-27"><a href="#cb14-27"></a></span>
+<span id="cb14-28"><a href="#cb14-28"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-29"><a href="#cb14-29"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb14-30"><a href="#cb14-30"></a></span>
+<span id="cb14-31"><a href="#cb14-31"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb14-32"><a href="#cb14-32"></a>  <span class="fu">filter</span>(</span>
+<span id="cb14-33"><a href="#cb14-33"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-34"><a href="#cb14-34"></a>    PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>,</span>
+<span id="cb14-35"><a href="#cb14-35"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span>,</span>
+<span id="cb14-36"><a href="#cb14-36"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb14-37"><a href="#cb14-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-38"><a href="#cb14-38"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span>
+<span id="cb14-39"><a href="#cb14-39"></a><span class="in">```</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a></span>
+<span id="cb14-41"><a href="#cb14-41"></a><span class="fu">## Standard Plot</span></span>
+<span id="cb14-42"><a href="#cb14-42"></a></span>
+<span id="cb14-43"><a href="#cb14-43"></a>The user can select different <span class="in">`plotting_choices`</span> depending on their preference.</span>
+<span id="cb14-44"><a href="#cb14-44"></a>To demonstrate, separate plots are produced with a maximum of 3 observations each.</span>
+<span id="cb14-45"><a href="#cb14-45"></a></span>
+<span id="cb14-46"><a href="#cb14-46"></a><span class="in">```{r plots1, test = list(plots_v1 = "plots")}</span></span>
+<span id="cb14-47"><a href="#cb14-47"></a>plots <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb14-48"><a href="#cb14-48"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb14-49"><a href="#cb14-49"></a>  <span class="at">xvar =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb14-50"><a href="#cb14-50"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-51"><a href="#cb14-51"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb14-52"><a href="#cb14-52"></a>  <span class="at">ylab =</span> <span class="st">"SGOT/ALT (U/L)"</span>,</span>
+<span id="cb14-53"><a href="#cb14-53"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb14-54"><a href="#cb14-54"></a>  <span class="at">title =</span> <span class="st">"Individual Patient Plots"</span>,</span>
+<span id="cb14-55"><a href="#cb14-55"></a>  <span class="at">subtitle =</span> <span class="st">"Treatment Arm A"</span>,</span>
+<span id="cb14-56"><a href="#cb14-56"></a>  <span class="at">plotting_choices =</span> <span class="st">"split_by_max_obs"</span>,</span>
+<span id="cb14-57"><a href="#cb14-57"></a>  <span class="at">max_obs_per_plot =</span> <span class="dv">3</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a>)</span>
+<span id="cb14-59"><a href="#cb14-59"></a>plots</span>
+<span id="cb14-60"><a href="#cb14-60"></a><span class="in">```</span></span>
+<span id="cb14-61"><a href="#cb14-61"></a></span>
+<span id="cb14-62"><a href="#cb14-62"></a><span class="fu">## Plot with Patient Baselines as Reference</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a></span>
+<span id="cb14-64"><a href="#cb14-64"></a>Here, patients' individual baseline values will be shown for reference.</span>
+<span id="cb14-65"><a href="#cb14-65"></a>Note that users can provide their own custom theme to the function via the <span class="in">`ggtheme`</span> argument.</span>
+<span id="cb14-66"><a href="#cb14-66"></a></span>
+<span id="cb14-67"><a href="#cb14-67"></a><span class="in">```{r plots2, test = list(plots_v2 = "plots")}</span></span>
+<span id="cb14-68"><a href="#cb14-68"></a>plots <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb14-69"><a href="#cb14-69"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb14-70"><a href="#cb14-70"></a>  <span class="at">xvar =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb14-71"><a href="#cb14-71"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-72"><a href="#cb14-72"></a>  <span class="at">xlab =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb14-73"><a href="#cb14-73"></a>  <span class="at">ylab =</span> <span class="st">"SGOT/ALT (U/L)"</span>,</span>
+<span id="cb14-74"><a href="#cb14-74"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>  <span class="at">title =</span> <span class="st">"Individual Patient Plots"</span>,</span>
+<span id="cb14-76"><a href="#cb14-76"></a>  <span class="at">subtitle =</span> <span class="st">"Treatment Arm A"</span>,</span>
+<span id="cb14-77"><a href="#cb14-77"></a>  <span class="at">add_baseline_hline =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb14-78"><a href="#cb14-78"></a>  <span class="at">yvar_baseline =</span> <span class="st">"BASE"</span>,</span>
+<span id="cb14-79"><a href="#cb14-79"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_minimal</span>(),</span>
+<span id="cb14-80"><a href="#cb14-80"></a>  <span class="at">plotting_choices =</span> <span class="st">"split_by_max_obs"</span>,</span>
+<span id="cb14-81"><a href="#cb14-81"></a>  <span class="at">max_obs_per_plot =</span> <span class="dv">3</span></span>
+<span id="cb14-82"><a href="#cb14-82"></a>)</span>
+<span id="cb14-83"><a href="#cb14-83"></a>plots</span>
+<span id="cb14-84"><a href="#cb14-84"></a><span class="in">```</span></span>
+<span id="cb14-85"><a href="#cb14-85"></a></span>
+<span id="cb14-86"><a href="#cb14-86"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-87"><a href="#cb14-87"></a></span>
+<span id="cb14-88"><a href="#cb14-88"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a></span>
+<span id="cb14-90"><a href="#cb14-90"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-91"><a href="#cb14-91"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb14-92"><a href="#cb14-92"></a></span>
+<span id="cb14-93"><a href="#cb14-93"></a><span class="fu">library</span>(teal)</span>
+<span id="cb14-94"><a href="#cb14-94"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-95"><a href="#cb14-95"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-96"><a href="#cb14-96"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-97"><a href="#cb14-97"></a></span>
+<span id="cb14-98"><a href="#cb14-98"></a><span class="co"># use small sample size</span></span>
+<span id="cb14-99"><a href="#cb14-99"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>)</span>
+<span id="cb14-100"><a href="#cb14-100"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb14-101"><a href="#cb14-101"></a></span>
+<span id="cb14-102"><a href="#cb14-102"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-103"><a href="#cb14-103"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-104"><a href="#cb14-104"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb) <span class="sc">%&gt;%</span></span>
+<span id="cb14-105"><a href="#cb14-105"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span>)</span>
+<span id="cb14-106"><a href="#cb14-106"></a></span>
+<span id="cb14-107"><a href="#cb14-107"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-108"><a href="#cb14-108"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-110"><a href="#cb14-110"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb14-111"><a href="#cb14-111"></a>      adsl,</span>
+<span id="cb14-112"><a href="#cb14-112"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% slice(1:15)</span></span>
+<span id="cb14-113"><a href="#cb14-113"></a><span class="st">               ADSL &lt;- df_explicit_na(ADSL)'</span></span>
+<span id="cb14-114"><a href="#cb14-114"></a>    ),</span>
+<span id="cb14-115"><a href="#cb14-115"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-116"><a href="#cb14-116"></a>      <span class="st">"ADLB"</span>,</span>
+<span id="cb14-117"><a href="#cb14-117"></a>      adlb,</span>
+<span id="cb14-118"><a href="#cb14-118"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;% filter(USUBJID %in% adsl$USUBJID)</span></span>
+<span id="cb14-119"><a href="#cb14-119"></a><span class="st">             ADLB &lt;- df_explicit_na(ADLB) %&gt;%</span></span>
+<span id="cb14-120"><a href="#cb14-120"></a><span class="st">               dplyr::filter(USUBJID %in% ADSL$USUBJID,</span></span>
+<span id="cb14-121"><a href="#cb14-121"></a><span class="st">                             AVISIT != "SCREENING")'</span></span>
+<span id="cb14-122"><a href="#cb14-122"></a>    )</span>
+<span id="cb14-123"><a href="#cb14-123"></a>  ),</span>
+<span id="cb14-124"><a href="#cb14-124"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-125"><a href="#cb14-125"></a>    <span class="fu">tm_g_ipp</span>(</span>
+<span id="cb14-126"><a href="#cb14-126"></a>      <span class="at">label =</span> <span class="st">"Individual Patient Plot"</span>,</span>
+<span id="cb14-127"><a href="#cb14-127"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb14-128"><a href="#cb14-128"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-129"><a href="#cb14-129"></a>        <span class="fu">value_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"ARMCD"</span>)),</span>
+<span id="cb14-130"><a href="#cb14-130"></a>        <span class="st">"ARM A"</span></span>
+<span id="cb14-131"><a href="#cb14-131"></a>      ),</span>
+<span id="cb14-132"><a href="#cb14-132"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-133"><a href="#cb14-133"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb14-134"><a href="#cb14-134"></a>        <span class="st">"ALT"</span></span>
+<span id="cb14-135"><a href="#cb14-135"></a>      ),</span>
+<span id="cb14-136"><a href="#cb14-136"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-137"><a href="#cb14-137"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>)),</span>
+<span id="cb14-138"><a href="#cb14-138"></a>        <span class="st">"AVAL"</span></span>
+<span id="cb14-139"><a href="#cb14-139"></a>      ),</span>
+<span id="cb14-140"><a href="#cb14-140"></a>      <span class="at">avalu_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-141"><a href="#cb14-141"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVALU"</span>)),</span>
+<span id="cb14-142"><a href="#cb14-142"></a>        <span class="st">"AVALU"</span>,</span>
+<span id="cb14-143"><a href="#cb14-143"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-144"><a href="#cb14-144"></a>      ),</span>
+<span id="cb14-145"><a href="#cb14-145"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-146"><a href="#cb14-146"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"USUBJID"</span>)),</span>
+<span id="cb14-147"><a href="#cb14-147"></a>        <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-148"><a href="#cb14-148"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-149"><a href="#cb14-149"></a>      ),</span>
+<span id="cb14-150"><a href="#cb14-150"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-151"><a href="#cb14-151"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVISIT"</span>)),</span>
+<span id="cb14-152"><a href="#cb14-152"></a>        <span class="st">"AVISIT"</span></span>
+<span id="cb14-153"><a href="#cb14-153"></a>      ),</span>
+<span id="cb14-154"><a href="#cb14-154"></a>      <span class="at">base_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-155"><a href="#cb14-155"></a>        <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"BASE"</span>)),</span>
+<span id="cb14-156"><a href="#cb14-156"></a>        <span class="st">"BASE"</span>,</span>
+<span id="cb14-157"><a href="#cb14-157"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-158"><a href="#cb14-158"></a>      ),</span>
+<span id="cb14-159"><a href="#cb14-159"></a>      <span class="at">add_baseline_hline =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-160"><a href="#cb14-160"></a>      <span class="at">separate_by_obs =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-161"><a href="#cb14-161"></a>    )</span>
+<span id="cb14-162"><a href="#cb14-162"></a>  )</span>
+<span id="cb14-163"><a href="#cb14-163"></a>)</span>
+<span id="cb14-164"><a href="#cb14-164"></a></span>
+<span id="cb14-165"><a href="#cb14-165"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-166"><a href="#cb14-166"></a><span class="in">```</span></span>
+<span id="cb14-167"><a href="#cb14-167"></a></span>
+<span id="cb14-168"><a href="#cb14-168"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-169"><a href="#cb14-169"></a></span>
+<span id="cb14-170"><a href="#cb14-170"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">KMG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Kaplan-Meier Plot</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Plot</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot of Failures</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot Without <br> Comparative Statistics</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot Without <br> Censoring Marks</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Plot Modifying <br> Censoring Marks</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Plot Modifying Options for Statistics, <br> Tie Handling, Stratification, etc.</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="kmg01_cache/html/setup_ec36b030c2b3b4dd8772f62a4d419b4f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>anl <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARMCD"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot1_a0d1116853c2fa667395ae0b2e261aa6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.162] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot2_1f3212bc887cb02b400f89a7a7608478">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="at">yval =</span> <span class="st">"Failure"</span>,</span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="at">annot_surv_med =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb5-8"><a href="#cb5-8"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="at">font_size =</span> <span class="fl">7.5</span>,</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  <span class="at">position_coxph =</span> <span class="fu">c</span>(<span class="fl">0.3</span>, <span class="dv">0</span>),</span>
+<span id="cb5-11"><a href="#cb5-11"></a>  <span class="at">position_surv_med =</span> <span class="fu">c</span>(<span class="fl">0.9</span>, <span class="fl">0.3</span>)</span>
+<span id="cb5-12"><a href="#cb5-12"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.312] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot3_b5870d2e669bf5cda946ab04e52f7d91">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="at">annot_surv_med =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.436] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot4_543f4d5b717e1594e78d652ba0fec2f2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb11-2"><a href="#cb11-2"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb11-3"><a href="#cb11-3"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb11-4"><a href="#cb11-4"></a>  <span class="at">censor_show =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb11-5"><a href="#cb11-5"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb11-6"><a href="#cb11-6"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb11-7"><a href="#cb11-7"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-8"><a href="#cb11-8"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.572] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot5_bf3070a9fe83d4a37b01b465943a7a31">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb14-2"><a href="#cb14-2"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb14-3"><a href="#cb14-3"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb14-4"><a href="#cb14-4"></a>  <span class="at">pch =</span> <span class="dv">1</span>,</span>
+<span id="cb14-5"><a href="#cb14-5"></a>  <span class="at">size =</span> <span class="dv">2</span>,</span>
+<span id="cb14-6"><a href="#cb14-6"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb14-7"><a href="#cb14-7"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb14-8"><a href="#cb14-8"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-9"><a href="#cb14-9"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot5-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.722] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;plot_v6&quot;:&quot;plot&quot;}" data-hash="kmg01_cache/html/plot6_93350a1a0fdcb43057efa3e5e6c80f5e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>variables<span class="sc">$</span>strat <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb17-2"><a href="#cb17-2"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb17-3"><a href="#cb17-3"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb17-4"><a href="#cb17-4"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb17-5"><a href="#cb17-5"></a>  <span class="at">control_surv =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.8</span>),</span>
+<span id="cb17-6"><a href="#cb17-6"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb17-7"><a href="#cb17-7"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb17-8"><a href="#cb17-8"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  <span class="at">control_coxph_pw =</span> <span class="fu">control_coxph</span>(</span>
+<span id="cb17-10"><a href="#cb17-10"></a>    <span class="at">pval_method =</span> <span class="st">"wald"</span>,</span>
+<span id="cb17-11"><a href="#cb17-11"></a>    <span class="at">ties =</span> <span class="st">"breslow"</span>,</span>
+<span id="cb17-12"><a href="#cb17-12"></a>    <span class="at">conf_level =</span> <span class="fl">0.8</span></span>
+<span id="cb17-13"><a href="#cb17-13"></a>  )</span>
+<span id="cb17-14"><a href="#cb17-14"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/plot6-1.png" class="img-fluid" width="1440"></p>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>gTree[GRID.gTree.872] </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:36}" data-hash="kmg01_cache/html/teal_3ff29381dbd5ba7b40ec6f7d512ad789">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb20"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb20-1"><a href="#cb20-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb20-2"><a href="#cb20-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb20-3"><a href="#cb20-3"></a></span>
+<span id="cb20-4"><a href="#cb20-4"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb20-5"><a href="#cb20-5"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb20-6"><a href="#cb20-6"></a></span>
+<span id="cb20-7"><a href="#cb20-7"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb20-8"><a href="#cb20-8"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb20-9"><a href="#cb20-9"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb20-10"><a href="#cb20-10"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb20-11"><a href="#cb20-11"></a>  ),</span>
+<span id="cb20-12"><a href="#cb20-12"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb20-13"><a href="#cb20-13"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb20-14"><a href="#cb20-14"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb20-15"><a href="#cb20-15"></a>  )</span>
+<span id="cb20-16"><a href="#cb20-16"></a>)</span>
+<span id="cb20-17"><a href="#cb20-17"></a></span>
+<span id="cb20-18"><a href="#cb20-18"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb20-19"><a href="#cb20-19"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb20-20"><a href="#cb20-20"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb20-21"><a href="#cb20-21"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte")'</span>),</span>
+<span id="cb20-22"><a href="#cb20-22"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb20-23"><a href="#cb20-23"></a>  ),</span>
+<span id="cb20-24"><a href="#cb20-24"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb20-25"><a href="#cb20-25"></a>    <span class="fu">tm_g_km</span>(</span>
+<span id="cb20-26"><a href="#cb20-26"></a>      <span class="at">label =</span> <span class="st">"KM PLOT"</span>,</span>
+<span id="cb20-27"><a href="#cb20-27"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(<span class="dv">600</span>, <span class="dv">100</span>, <span class="dv">2000</span>),</span>
+<span id="cb20-28"><a href="#cb20-28"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb20-29"><a href="#cb20-29"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-30"><a href="#cb20-30"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb20-31"><a href="#cb20-31"></a>        <span class="st">"ARM"</span></span>
+<span id="cb20-32"><a href="#cb20-32"></a>      ),</span>
+<span id="cb20-33"><a href="#cb20-33"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-34"><a href="#cb20-34"></a>        <span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb20-35"><a href="#cb20-35"></a>        <span class="st">"OS"</span></span>
+<span id="cb20-36"><a href="#cb20-36"></a>      ),</span>
+<span id="cb20-37"><a href="#cb20-37"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb20-38"><a href="#cb20-38"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-39"><a href="#cb20-39"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-40"><a href="#cb20-40"></a>        <span class="st">"SEX"</span></span>
+<span id="cb20-41"><a href="#cb20-41"></a>      ),</span>
+<span id="cb20-42"><a href="#cb20-42"></a>      <span class="at">facet_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-43"><a href="#cb20-43"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-44"><a href="#cb20-44"></a>        <span class="cn">NULL</span></span>
+<span id="cb20-45"><a href="#cb20-45"></a>      )</span>
+<span id="cb20-46"><a href="#cb20-46"></a>    )</span>
+<span id="cb20-47"><a href="#cb20-47"></a>  )</span>
+<span id="cb20-48"><a href="#cb20-48"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:51:12.4556 pid:5913 token:[] teal.modules.clinical Initializing tm_g_km</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb22"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb22-1"><a href="#cb22-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="kmg01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="kmg01_cache/html/sessioninfo_68bc9ed6ce1d079d9c8b8cc486af798f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb23"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb23-1"><a href="#cb23-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              dplyr_1.1.3                 
+ [9] scda_0.1.6                   tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        
+ [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        
+ [7] digest_0.6.33         estimability_1.4.1    mime_0.12            
+[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       
+[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       
+[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          
+[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           
+[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      
+[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   
+[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[34] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[37] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[40] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[43] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[49] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[52] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[55] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[58] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[61] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[64] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[67] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[70] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[73] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[76] broom_1.0.5           teal.reporter_0.2.1   bslib_0.5.1          
+[79] httpuv_1.6.11         Rcpp_1.0.11           coda_0.19-4          
+[82] gridExtra_2.3         nlme_3.1-163          checkmate_2.2.0      
+[85] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="kmg01_cache/html/snapshot_631004804f80958e5a3639f5cbe5aa38">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb25"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb25-1"><a href="#cb25-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb25-2"><a href="#cb25-2"></a></span>
+<span id="cb25-3"><a href="#cb25-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb25-4"><a href="#cb25-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb25-5"><a href="#cb25-5"></a></span>
+<span id="cb25-6"><a href="#cb25-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb25-7"><a href="#cb25-7"></a></span>
+<span id="cb25-8"><a href="#cb25-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb25-9"><a href="#cb25-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb25-10"><a href="#cb25-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb25-11"><a href="#cb25-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/kmg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
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+    for (let i=0; i < stylesheets.length; i++) {
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+      stylesheet.rel = 'stylesheet';
+    }
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+  const manageTransitions = (selector, allowTransitions) => {
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+      } else {
+        el.classList.add('notransition');
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
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+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
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+          toggle.classList.add("alternate");     
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+          toggle.classList.remove("alternate");
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+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
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+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
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+  // Dark / light mode switch
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb26" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb26-1"><a href="#cb26-1"></a><span class="co">---</span></span>
+<span id="cb26-2"><a href="#cb26-2"></a><span class="an">title:</span><span class="co"> KMG01</span></span>
+<span id="cb26-3"><a href="#cb26-3"></a><span class="an">subtitle:</span><span class="co"> Kaplan-Meier Plot</span></span>
+<span id="cb26-4"><a href="#cb26-4"></a><span class="co">---</span></span>
+<span id="cb26-5"><a href="#cb26-5"></a></span>
+<span id="cb26-6"><a href="#cb26-6"></a>------------------------------------------------------------------------</span>
+<span id="cb26-7"><a href="#cb26-7"></a></span>
+<span id="cb26-8"><a href="#cb26-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb26-9"><a href="#cb26-9"></a></span>
+<span id="cb26-10"><a href="#cb26-10"></a>::: panel-tabset</span>
+<span id="cb26-11"><a href="#cb26-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb26-12"><a href="#cb26-12"></a></span>
+<span id="cb26-13"><a href="#cb26-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb26-14"><a href="#cb26-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb26-15"><a href="#cb26-15"></a></span>
+<span id="cb26-16"><a href="#cb26-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb26-17"><a href="#cb26-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb26-18"><a href="#cb26-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb26-19"><a href="#cb26-19"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb26-20"><a href="#cb26-20"></a></span>
+<span id="cb26-21"><a href="#cb26-21"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb26-22"><a href="#cb26-22"></a>anl <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb26-23"><a href="#cb26-23"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb26-24"><a href="#cb26-24"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>)</span>
+<span id="cb26-25"><a href="#cb26-25"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="at">tte =</span> <span class="st">"AVAL"</span>, <span class="at">is_event =</span> <span class="st">"is_event"</span>, <span class="at">arm =</span> <span class="st">"ARMCD"</span>)</span>
+<span id="cb26-26"><a href="#cb26-26"></a><span class="in">```</span></span>
+<span id="cb26-27"><a href="#cb26-27"></a></span>
+<span id="cb26-28"><a href="#cb26-28"></a><span class="fu">## Standard Plot</span></span>
+<span id="cb26-29"><a href="#cb26-29"></a></span>
+<span id="cb26-30"><a href="#cb26-30"></a><span class="in">```{r plot1, fig.height=8, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb26-31"><a href="#cb26-31"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-32"><a href="#cb26-32"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-33"><a href="#cb26-33"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-34"><a href="#cb26-34"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-35"><a href="#cb26-35"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-36"><a href="#cb26-36"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb26-37"><a href="#cb26-37"></a>)</span>
+<span id="cb26-38"><a href="#cb26-38"></a>plot</span>
+<span id="cb26-39"><a href="#cb26-39"></a><span class="in">```</span></span>
+<span id="cb26-40"><a href="#cb26-40"></a></span>
+<span id="cb26-41"><a href="#cb26-41"></a><span class="fu">## Plot of Failures</span></span>
+<span id="cb26-42"><a href="#cb26-42"></a></span>
+<span id="cb26-43"><a href="#cb26-43"></a><span class="in">```{r plot2, fig.height=8, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb26-44"><a href="#cb26-44"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-45"><a href="#cb26-45"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-46"><a href="#cb26-46"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-47"><a href="#cb26-47"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-48"><a href="#cb26-48"></a>  <span class="at">yval =</span> <span class="st">"Failure"</span>,</span>
+<span id="cb26-49"><a href="#cb26-49"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-50"><a href="#cb26-50"></a>  <span class="at">annot_surv_med =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb26-51"><a href="#cb26-51"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb26-52"><a href="#cb26-52"></a>  <span class="at">font_size =</span> <span class="fl">7.5</span>,</span>
+<span id="cb26-53"><a href="#cb26-53"></a>  <span class="at">position_coxph =</span> <span class="fu">c</span>(<span class="fl">0.3</span>, <span class="dv">0</span>),</span>
+<span id="cb26-54"><a href="#cb26-54"></a>  <span class="at">position_surv_med =</span> <span class="fu">c</span>(<span class="fl">0.9</span>, <span class="fl">0.3</span>)</span>
+<span id="cb26-55"><a href="#cb26-55"></a>)</span>
+<span id="cb26-56"><a href="#cb26-56"></a>plot</span>
+<span id="cb26-57"><a href="#cb26-57"></a><span class="in">```</span></span>
+<span id="cb26-58"><a href="#cb26-58"></a></span>
+<span id="cb26-59"><a href="#cb26-59"></a><span class="fu">## Plot Without &lt;br/&gt; Comparative Statistics</span></span>
+<span id="cb26-60"><a href="#cb26-60"></a></span>
+<span id="cb26-61"><a href="#cb26-61"></a><span class="in">```{r plot3, fig.height=8, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb26-62"><a href="#cb26-62"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-63"><a href="#cb26-63"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-64"><a href="#cb26-64"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-65"><a href="#cb26-65"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-66"><a href="#cb26-66"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-67"><a href="#cb26-67"></a>  <span class="at">annot_surv_med =</span> <span class="cn">TRUE</span></span>
+<span id="cb26-68"><a href="#cb26-68"></a>)</span>
+<span id="cb26-69"><a href="#cb26-69"></a>plot</span>
+<span id="cb26-70"><a href="#cb26-70"></a><span class="in">```</span></span>
+<span id="cb26-71"><a href="#cb26-71"></a></span>
+<span id="cb26-72"><a href="#cb26-72"></a><span class="fu">## Plot Without &lt;br/&gt; Censoring Marks</span></span>
+<span id="cb26-73"><a href="#cb26-73"></a></span>
+<span id="cb26-74"><a href="#cb26-74"></a><span class="in">```{r plot4, fig.height=8, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb26-75"><a href="#cb26-75"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-76"><a href="#cb26-76"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-77"><a href="#cb26-77"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-78"><a href="#cb26-78"></a>  <span class="at">censor_show =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb26-79"><a href="#cb26-79"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-80"><a href="#cb26-80"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-81"><a href="#cb26-81"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb26-82"><a href="#cb26-82"></a>)</span>
+<span id="cb26-83"><a href="#cb26-83"></a>plot</span>
+<span id="cb26-84"><a href="#cb26-84"></a><span class="in">```</span></span>
+<span id="cb26-85"><a href="#cb26-85"></a></span>
+<span id="cb26-86"><a href="#cb26-86"></a><span class="fu">## Plot Modifying &lt;br/&gt; Censoring Marks</span></span>
+<span id="cb26-87"><a href="#cb26-87"></a></span>
+<span id="cb26-88"><a href="#cb26-88"></a><span class="in">```{r plot5, fig.height=8, test = list(plot_v5 = "plot")}</span></span>
+<span id="cb26-89"><a href="#cb26-89"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-90"><a href="#cb26-90"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-91"><a href="#cb26-91"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-92"><a href="#cb26-92"></a>  <span class="at">pch =</span> <span class="dv">1</span>,</span>
+<span id="cb26-93"><a href="#cb26-93"></a>  <span class="at">size =</span> <span class="dv">2</span>,</span>
+<span id="cb26-94"><a href="#cb26-94"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-95"><a href="#cb26-95"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-96"><a href="#cb26-96"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span></span>
+<span id="cb26-97"><a href="#cb26-97"></a>)</span>
+<span id="cb26-98"><a href="#cb26-98"></a>plot</span>
+<span id="cb26-99"><a href="#cb26-99"></a><span class="in">```</span></span>
+<span id="cb26-100"><a href="#cb26-100"></a></span>
+<span id="cb26-101"><a href="#cb26-101"></a><span class="fu">## Plot Modifying Options for Statistics, &lt;br/&gt; Tie Handling, Stratification, etc.</span></span>
+<span id="cb26-102"><a href="#cb26-102"></a></span>
+<span id="cb26-103"><a href="#cb26-103"></a><span class="in">```{r plot6, test = list(plot_v6 = "plot")}</span></span>
+<span id="cb26-104"><a href="#cb26-104"></a>variables<span class="sc">$</span>strat <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb26-105"><a href="#cb26-105"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_km</span>(</span>
+<span id="cb26-106"><a href="#cb26-106"></a>  <span class="at">df =</span> anl,</span>
+<span id="cb26-107"><a href="#cb26-107"></a>  <span class="at">variables =</span> variables,</span>
+<span id="cb26-108"><a href="#cb26-108"></a>  <span class="at">control_surv =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.8</span>),</span>
+<span id="cb26-109"><a href="#cb26-109"></a>  <span class="at">xlab =</span> <span class="st">"Time (Days)"</span>,</span>
+<span id="cb26-110"><a href="#cb26-110"></a>  <span class="at">ylim =</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>),</span>
+<span id="cb26-111"><a href="#cb26-111"></a>  <span class="at">annot_coxph =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb26-112"><a href="#cb26-112"></a>  <span class="at">control_coxph_pw =</span> <span class="fu">control_coxph</span>(</span>
+<span id="cb26-113"><a href="#cb26-113"></a>    <span class="at">pval_method =</span> <span class="st">"wald"</span>,</span>
+<span id="cb26-114"><a href="#cb26-114"></a>    <span class="at">ties =</span> <span class="st">"breslow"</span>,</span>
+<span id="cb26-115"><a href="#cb26-115"></a>    <span class="at">conf_level =</span> <span class="fl">0.8</span></span>
+<span id="cb26-116"><a href="#cb26-116"></a>  )</span>
+<span id="cb26-117"><a href="#cb26-117"></a>)</span>
+<span id="cb26-118"><a href="#cb26-118"></a>plot</span>
+<span id="cb26-119"><a href="#cb26-119"></a><span class="in">```</span></span>
+<span id="cb26-120"><a href="#cb26-120"></a></span>
+<span id="cb26-121"><a href="#cb26-121"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb26-122"><a href="#cb26-122"></a></span>
+<span id="cb26-123"><a href="#cb26-123"></a><span class="fu">## `teal` App</span></span>
+<span id="cb26-124"><a href="#cb26-124"></a></span>
+<span id="cb26-125"><a href="#cb26-125"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb26-126"><a href="#cb26-126"></a><span class="co">#| screenshot.opts = list(delay = 36)</span></span>
+<span id="cb26-127"><a href="#cb26-127"></a></span>
+<span id="cb26-128"><a href="#cb26-128"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb26-129"><a href="#cb26-129"></a><span class="fu">library</span>(scda)</span>
+<span id="cb26-130"><a href="#cb26-130"></a></span>
+<span id="cb26-131"><a href="#cb26-131"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb26-132"><a href="#cb26-132"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb26-133"><a href="#cb26-133"></a></span>
+<span id="cb26-134"><a href="#cb26-134"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb26-135"><a href="#cb26-135"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb26-136"><a href="#cb26-136"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb26-137"><a href="#cb26-137"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb26-138"><a href="#cb26-138"></a>  ),</span>
+<span id="cb26-139"><a href="#cb26-139"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb26-140"><a href="#cb26-140"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb26-141"><a href="#cb26-141"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb26-142"><a href="#cb26-142"></a>  )</span>
+<span id="cb26-143"><a href="#cb26-143"></a>)</span>
+<span id="cb26-144"><a href="#cb26-144"></a></span>
+<span id="cb26-145"><a href="#cb26-145"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb26-146"><a href="#cb26-146"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb26-147"><a href="#cb26-147"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb26-148"><a href="#cb26-148"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte")'</span>),</span>
+<span id="cb26-149"><a href="#cb26-149"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb26-150"><a href="#cb26-150"></a>  ),</span>
+<span id="cb26-151"><a href="#cb26-151"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb26-152"><a href="#cb26-152"></a>    <span class="fu">tm_g_km</span>(</span>
+<span id="cb26-153"><a href="#cb26-153"></a>      <span class="at">label =</span> <span class="st">"KM PLOT"</span>,</span>
+<span id="cb26-154"><a href="#cb26-154"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(<span class="dv">600</span>, <span class="dv">100</span>, <span class="dv">2000</span>),</span>
+<span id="cb26-155"><a href="#cb26-155"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb26-156"><a href="#cb26-156"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb26-157"><a href="#cb26-157"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb26-158"><a href="#cb26-158"></a>        <span class="st">"ARM"</span></span>
+<span id="cb26-159"><a href="#cb26-159"></a>      ),</span>
+<span id="cb26-160"><a href="#cb26-160"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb26-161"><a href="#cb26-161"></a>        <span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb26-162"><a href="#cb26-162"></a>        <span class="st">"OS"</span></span>
+<span id="cb26-163"><a href="#cb26-163"></a>      ),</span>
+<span id="cb26-164"><a href="#cb26-164"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb26-165"><a href="#cb26-165"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb26-166"><a href="#cb26-166"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb26-167"><a href="#cb26-167"></a>        <span class="st">"SEX"</span></span>
+<span id="cb26-168"><a href="#cb26-168"></a>      ),</span>
+<span id="cb26-169"><a href="#cb26-169"></a>      <span class="at">facet_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb26-170"><a href="#cb26-170"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb26-171"><a href="#cb26-171"></a>        <span class="cn">NULL</span></span>
+<span id="cb26-172"><a href="#cb26-172"></a>      )</span>
+<span id="cb26-173"><a href="#cb26-173"></a>    )</span>
+<span id="cb26-174"><a href="#cb26-174"></a>  )</span>
+<span id="cb26-175"><a href="#cb26-175"></a>)</span>
+<span id="cb26-176"><a href="#cb26-176"></a></span>
+<span id="cb26-177"><a href="#cb26-177"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb26-178"><a href="#cb26-178"></a><span class="in">```</span></span>
+<span id="cb26-179"><a href="#cb26-179"></a></span>
+<span id="cb26-180"><a href="#cb26-180"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb26-181"><a href="#cb26-181"></a></span>
+<span id="cb26-182"><a href="#cb26-182"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LTG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Lattice Plot of Laboratory Tests by Treatment Group Over Time</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>Lattice plots are natively handled by R, the examples below rely mostly on the package <code>ggplot2</code>.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of Liver Function Tests</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot of Liver Function Tests <br> Including Mean, Median, and 95% CIs</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ltg01_cache/html/setup_e92bca2782d4973042f04b61cfc6032b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(teal)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Datasets</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">8</span>)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># Pre-processing</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb<span class="sc">$</span>AVISIT_txt <span class="ot">&lt;-</span> adlb<span class="sc">$</span>AVISIT</span>
+<span id="cb1-15"><a href="#cb1-15"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>adlb<span class="sc">$</span>ARM_N <span class="ot">&lt;-</span> adlb<span class="sc">$</span>ARM</span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="fu">levels</span>(adlb<span class="sc">$</span>ARM_N) <span class="ot">&lt;-</span> <span class="fu">with</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">paste0</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="fu">levels</span>(ARM_N), <span class="st">" (N = "</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="fu">tapply</span>(SUBJID, ARM_N, <span class="cf">function</span>(x) <span class="fu">length</span>(<span class="fu">unique</span>(x))), <span class="st">")"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  )</span>
+<span id="cb1-23"><a href="#cb1-23"></a>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="co"># Plot utils</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>npch <span class="ot">&lt;-</span> <span class="dv">1</span><span class="sc">:</span><span class="dv">25</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>npatients <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(adlb<span class="sc">$</span>SUBJID))</span>
+<span id="cb1-28"><a href="#cb1-28"></a>pch <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">rep</span>(npch, <span class="at">times =</span> npatients <span class="sc">%/%</span> <span class="fu">length</span>(npch)),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  npch[<span class="dv">1</span><span class="sc">:</span>(npatients <span class="sc">%%</span> <span class="fu">length</span>(npch))]</span>
+<span id="cb1-31"><a href="#cb1-31"></a>)</span>
+<span id="cb1-32"><a href="#cb1-32"></a></span>
+<span id="cb1-33"><a href="#cb1-33"></a><span class="co"># Add the mean along with the 95% CI at every visit.</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>mean_95_text <span class="ot">&lt;-</span> <span class="st">"Mean +/- 95% CI"</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a><span class="co"># Add the median and 95% CI as follows.</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>median_95_text <span class="ot">&lt;-</span> <span class="st">"Median +/- 95% CI"</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a><span class="co"># Add the median and 95% CI as follows.</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>median_80_text <span class="ot">&lt;-</span> <span class="st">"Median +/- 80% CI"</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<section id="basic-plot" class="level4"><h4 class="anchored" data-anchor-id="basic-plot">Basic Plot</h4>
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot1_3fc40aaf47252db116a25558f500a8c0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># General mapping and "lattice" ("facet" in ggplot2 nomenclature).</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>g1 <span class="ot">&lt;-</span> {</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">ggplot</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">data =</span> adlb,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">mapping =</span> <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">colour =</span> SUBJID, <span class="at">shape =</span> SUBJID)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="fu">facet_grid</span>(LBTESTCD <span class="sc">~</span> ARM, <span class="at">scales =</span> <span class="st">"free_y"</span>) <span class="sc">+</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="fu">scale_shape_manual</span>(<span class="at">values =</span> pch)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>}</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a><span class="co"># Add points and lines.</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>g1 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">geom_point</span>()</span>
+<span id="cb2-13"><a href="#cb2-13"></a>g1 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">geom_line</span>()</span>
+<span id="cb2-14"><a href="#cb2-14"></a>plot <span class="ot">&lt;-</span> g1</span>
+<span id="cb2-15"><a href="#cb2-15"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="modifying-facets" class="level4"><h4 class="anchored" data-anchor-id="modifying-facets">Modifying Facets</h4>
+<p>The units describing rows of panes and the number of patients under each arm is specified by modifying <code>facet_grid()</code>:</p>
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot2_83da2e13b268227eff702e40d1eaeb22">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a><span class="co"># Include the units and the sample size N.</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>g2 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">facet_grid</span>(</span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">paste0</span>(LBTESTCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">")"</span>) <span class="sc">~</span> ARM_N,</span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="at">scales =</span> <span class="st">"free_y"</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>)</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>plot <span class="ot">&lt;-</span> g2</span>
+<span id="cb3-8"><a href="#cb3-8"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="modifying-x-axis" class="level4"><h4 class="anchored" data-anchor-id="modifying-x-axis">Modifying X-Axis</h4>
+<p>The graphic elements are modified through usual <code>ggplot2</code> functions. For instance, the x-axis could be improved as follows:</p>
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;g3&quot;}" data-hash="ltg01_cache/html/plot3_0fd8bb96f218892123d66f6bd2ef5c23">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>g3 <span class="ot">&lt;-</span> g2 <span class="sc">+</span> <span class="fu">theme</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_text</span>(<span class="at">angle =</span> <span class="dv">45</span>, <span class="at">hjust =</span> <span class="dv">1</span>),</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb4-4"><a href="#cb4-4"></a>) <span class="sc">+</span> <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> adlb<span class="sc">$</span>AVISIT, <span class="at">labels =</span> adlb<span class="sc">$</span>AVISIT_txt)</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a>plot <span class="ot">&lt;-</span> g3</span>
+<span id="cb4-7"><a href="#cb4-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The functions <code>stat_mean_ci</code> and <code>stat_median_ci</code> from the <code>tern</code> package allow the addition of mean and/or median confidence intervals. The example below suggests a larger dataset, where the individual subject legend may not be relevant but the mean or the median are of special interest.</p>
+<section id="pre-processing" class="level4"><h4 class="anchored" data-anchor-id="pre-processing">Pre-Processing</h4>
+<div class="cell" data-hash="ltg01_cache/html/pre-processing_242799d02c57641640053ea2f3aa27b4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="co"># Datasets</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">40</span>)</span>
+<span id="cb5-3"><a href="#cb5-3"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb5-4"><a href="#cb5-4"></a></span>
+<span id="cb5-5"><a href="#cb5-5"></a><span class="co"># Pre-processing</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>adlb<span class="sc">$</span>AVISIT_txt <span class="ot">&lt;-</span> adlb<span class="sc">$</span>AVISIT</span>
+<span id="cb5-7"><a href="#cb5-7"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb5-8"><a href="#cb5-8"></a>adlb<span class="sc">$</span>ARM_N <span class="ot">&lt;-</span> adlb<span class="sc">$</span>ARM</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">levels</span>(adlb<span class="sc">$</span>ARM_N) <span class="ot">&lt;-</span> <span class="fu">with</span>(</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>  <span class="fu">paste0</span>(</span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="fu">levels</span>(ARM_N), <span class="st">" (N = "</span>,</span>
+<span id="cb5-13"><a href="#cb5-13"></a>    <span class="fu">tapply</span>(SUBJID, ARM_N, <span class="cf">function</span>(x) <span class="fu">length</span>(<span class="fu">unique</span>(x))), <span class="st">")"</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a>  )</span>
+<span id="cb5-15"><a href="#cb5-15"></a>)</span>
+<span id="cb5-16"><a href="#cb5-16"></a></span>
+<span id="cb5-17"><a href="#cb5-17"></a><span class="co"># Plot utils</span></span>
+<span id="cb5-18"><a href="#cb5-18"></a>npch <span class="ot">&lt;-</span> <span class="dv">1</span><span class="sc">:</span><span class="dv">25</span></span>
+<span id="cb5-19"><a href="#cb5-19"></a>npatients <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(adlb<span class="sc">$</span>SUBJID))</span>
+<span id="cb5-20"><a href="#cb5-20"></a>pch <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb5-21"><a href="#cb5-21"></a>  <span class="fu">rep</span>(npch, <span class="at">times =</span> npatients <span class="sc">%/%</span> <span class="fu">length</span>(npch)),</span>
+<span id="cb5-22"><a href="#cb5-22"></a>  npch[<span class="dv">1</span><span class="sc">:</span>(npatients <span class="sc">%%</span> <span class="fu">length</span>(npch))]</span>
+<span id="cb5-23"><a href="#cb5-23"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="basic-plot-1" class="level4"><h4 class="anchored" data-anchor-id="basic-plot-1">Basic Plot</h4>
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot4_2b3e54023189b46a009d864322cc1c8c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># General mapping and "lattice" ("facet" in ggplot2 nomenclature)</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>g4 <span class="ot">&lt;-</span> {</span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">ggplot</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">data =</span> adlb,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">mapping =</span> <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">colour =</span> SUBJID, <span class="at">shape =</span> SUBJID)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="fu">facet_grid</span>(LBTESTCD <span class="sc">~</span> ARM_N, <span class="at">scales =</span> <span class="st">"free_y"</span>) <span class="sc">+</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="fu">scale_shape_manual</span>(<span class="at">values =</span> pch) <span class="sc">+</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="fu">scale_color_manual</span>(<span class="at">values =</span> <span class="fu">rep</span>(<span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.colour"</span>), <span class="dv">2</span>))</span>
+<span id="cb6-10"><a href="#cb6-10"></a>}</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a><span class="co"># Add points and lines.</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a><span class="co"># Note that with so many patients, legend might not be useful and transparency</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a><span class="co">#   is advisable.</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">geom_point</span>(<span class="at">alpha =</span> .<span class="dv">3</span>)</span>
+<span id="cb6-16"><a href="#cb6-16"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">geom_line</span>(<span class="at">alpha =</span> .<span class="dv">3</span>)</span>
+<span id="cb6-17"><a href="#cb6-17"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">guides</span>(<span class="at">colour =</span> <span class="st">"none"</span>, <span class="at">shape =</span> <span class="st">"none"</span>)</span>
+<span id="cb6-18"><a href="#cb6-18"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">theme</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_text</span>(<span class="at">angle =</span> <span class="dv">45</span>, <span class="at">hjust =</span> <span class="dv">1</span>),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="at">axis.title  =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb6-21"><a href="#cb6-21"></a>)</span>
+<span id="cb6-22"><a href="#cb6-22"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> adlb<span class="sc">$</span>AVISIT, <span class="at">labels =</span> adlb<span class="sc">$</span>AVISIT_txt)</span>
+<span id="cb6-23"><a href="#cb6-23"></a>plot <span class="ot">&lt;-</span> g4</span>
+<span id="cb6-24"><a href="#cb6-24"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="adding-mean" class="level4"><h4 class="anchored" data-anchor-id="adding-mean">Adding Mean</h4>
+<div class="cell" data-test="{&quot;plot_v51&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot51_c522749cf95854521eea09388364d48a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>g51 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="at">fun =</span> mean, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> mean_95_text)</span>
+<span id="cb7-4"><a href="#cb7-4"></a>)</span>
+<span id="cb7-5"><a href="#cb7-5"></a>g51 <span class="ot">&lt;-</span> g51 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb7-6"><a href="#cb7-6"></a>  <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb7-7"><a href="#cb7-7"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> mean_95_text)</span>
+<span id="cb7-8"><a href="#cb7-8"></a>)</span>
+<span id="cb7-9"><a href="#cb7-9"></a>plot <span class="ot">&lt;-</span> g51</span>
+<span id="cb7-10"><a href="#cb7-10"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot51-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="adding-median" class="level4"><h4 class="anchored" data-anchor-id="adding-median">Adding Median</h4>
+<div class="cell" data-test="{&quot;plot_v52&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot52_f537b57d38425248250dd65605aa2f6b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="co"># Instead of a mean, the median could be more relevant.</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>g52 <span class="ot">&lt;-</span> g51 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">fun =</span> median, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_95_text)</span>
+<span id="cb8-5"><a href="#cb8-5"></a>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a>g52 <span class="ot">&lt;-</span> g52 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_median_ci, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_95_text)</span>
+<span id="cb8-9"><a href="#cb8-9"></a>)</span>
+<span id="cb8-10"><a href="#cb8-10"></a>plot <span class="ot">&lt;-</span> g52 <span class="sc">+</span> <span class="fu">guides</span>(<span class="at">linetype =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="st">"Aggregate"</span>))</span>
+<span id="cb8-11"><a href="#cb8-11"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot52-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="changing-confidence-level" class="level4"><h4 class="anchored" data-anchor-id="changing-confidence-level">Changing Confidence Level</h4>
+<div class="cell" data-test="{&quot;plot_v53&quot;:&quot;plot&quot;}" data-hash="ltg01_cache/html/plot53_c0ca1bb42bd19b077f98a12226933ebd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="co"># Change the confidence level of interval for the median.</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="co"># Note: check `?stat_mean_ci()` and `?stat_median_ci()` for further fine tuning.</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a>g53 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb9-4"><a href="#cb9-4"></a>  <span class="at">fun =</span> median, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb9-5"><a href="#cb9-5"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_80_text)</span>
+<span id="cb9-6"><a href="#cb9-6"></a>)</span>
+<span id="cb9-7"><a href="#cb9-7"></a>g53 <span class="ot">&lt;-</span> g53 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb9-8"><a href="#cb9-8"></a>  <span class="at">fun.data =</span> <span class="cf">function</span>(x) tern<span class="sc">::</span><span class="fu">stat_median_ci</span>(x, <span class="at">conf_level =</span> <span class="fl">0.8</span>),</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="at">geom =</span> <span class="st">"errorbar"</span>, <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_80_text)</span>
+<span id="cb9-10"><a href="#cb9-10"></a>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>plot <span class="ot">&lt;-</span> g53</span>
+<span id="cb9-12"><a href="#cb9-12"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ltg01_files/figure-html/plot53-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="ltg01_cache/html/teal_62140fee7eb8f2f3eb1a215669adff83">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ltg01_cache/html/sessioninfo_c475daaadded66cbcffdd002f874246b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] nestcolor_0.1.2              dplyr_1.1.3                 
+ [3] ggplot2_3.4.3                teal.modules.clinical_0.8.16
+ [5] teal_0.14.0                  teal.transform_0.4.0        
+ [7] teal.slice_0.4.0             teal.data_0.3.0             
+ [9] shiny_1.7.5                  tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0   farver_2.1.1       fastmap_1.1.1      TH.data_1.1-2     
+ [5] promises_1.2.1     shinyjs_2.1.0      digest_0.6.33      estimability_1.4.1
+ [9] mime_0.12          tern.gee_0.1.0     lifecycle_1.0.3    ellipsis_0.3.2    
+[13] survival_3.5-7     compiler_4.3.1     rlang_1.1.1        tools_4.3.1       
+[17] utf8_1.2.3         yaml_2.3.7         knitr_1.44         labeling_0.4.3    
+[21] htmlwidgets_1.6.2  multcomp_1.4-25    withr_2.5.0        purrr_1.0.2       
+[25] geepack_1.3.9      grid_4.3.1         fansi_1.0.4        teal.logger_0.1.3 
+[29] xtable_1.8-4       colorspace_2.1-0   emmeans_1.8.8      scales_1.2.1      
+[33] MASS_7.3-60        cli_3.6.1          mvtnorm_1.2-3      rmarkdown_2.25    
+[37] generics_0.1.3     rstudioapi_0.15.0  splines_4.3.1      assertthat_0.2.1  
+[41] vctrs_0.6.3        Matrix_1.6-1.1     sandwich_3.0-2     jsonlite_1.8.7    
+[45] testthat_3.1.10    tidyr_1.3.0        glue_1.6.2         codetools_0.2-19  
+[49] gtable_0.3.4       later_1.3.1        munsell_0.5.0      tibble_3.2.1      
+[53] logger_0.2.2       pillar_1.9.0       htmltools_0.5.6    brio_1.1.3        
+[57] R6_2.5.1           Rdpack_2.5         evaluate_0.21      lattice_0.21-8    
+[61] rbibutils_2.2.15   backports_1.4.1    broom_1.0.5        httpuv_1.6.11     
+[65] Rcpp_1.0.11        coda_0.19-4        nlme_3.1-163       checkmate_2.2.0   
+[69] xfun_0.40          zoo_1.8-12         pkgconfig_2.0.3   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ltg01_cache/html/snapshot_d6ee397963e87ee36c2878c760564da2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
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+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> LTG01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Lattice Plot of Laboratory Tests by Treatment Group Over Time</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>Lattice plots are natively handled by R, the examples below rely mostly on the package <span class="in">`ggplot2`</span>.</span>
+<span id="cb14-11"><a href="#cb14-11"></a></span>
+<span id="cb14-12"><a href="#cb14-12"></a>::: panel-tabset</span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a></span>
+<span id="cb14-15"><a href="#cb14-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-17"><a href="#cb14-17"></a></span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-20"><a href="#cb14-20"></a><span class="fu">library</span>(teal)</span>
+<span id="cb14-21"><a href="#cb14-21"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-22"><a href="#cb14-22"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb14-23"><a href="#cb14-23"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-24"><a href="#cb14-24"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb14-25"><a href="#cb14-25"></a></span>
+<span id="cb14-26"><a href="#cb14-26"></a><span class="co"># Datasets</span></span>
+<span id="cb14-27"><a href="#cb14-27"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">8</span>)</span>
+<span id="cb14-28"><a href="#cb14-28"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb14-29"><a href="#cb14-29"></a></span>
+<span id="cb14-30"><a href="#cb14-30"></a><span class="co"># Pre-processing</span></span>
+<span id="cb14-31"><a href="#cb14-31"></a>adlb<span class="sc">$</span>AVISIT_txt <span class="ot">&lt;-</span> adlb<span class="sc">$</span>AVISIT</span>
+<span id="cb14-32"><a href="#cb14-32"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb14-33"><a href="#cb14-33"></a>adlb<span class="sc">$</span>ARM_N <span class="ot">&lt;-</span> adlb<span class="sc">$</span>ARM</span>
+<span id="cb14-34"><a href="#cb14-34"></a><span class="fu">levels</span>(adlb<span class="sc">$</span>ARM_N) <span class="ot">&lt;-</span> <span class="fu">with</span>(</span>
+<span id="cb14-35"><a href="#cb14-35"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-36"><a href="#cb14-36"></a>  <span class="fu">paste0</span>(</span>
+<span id="cb14-37"><a href="#cb14-37"></a>    <span class="fu">levels</span>(ARM_N), <span class="st">" (N = "</span>,</span>
+<span id="cb14-38"><a href="#cb14-38"></a>    <span class="fu">tapply</span>(SUBJID, ARM_N, <span class="cf">function</span>(x) <span class="fu">length</span>(<span class="fu">unique</span>(x))), <span class="st">")"</span></span>
+<span id="cb14-39"><a href="#cb14-39"></a>  )</span>
+<span id="cb14-40"><a href="#cb14-40"></a>)</span>
+<span id="cb14-41"><a href="#cb14-41"></a></span>
+<span id="cb14-42"><a href="#cb14-42"></a><span class="co"># Plot utils</span></span>
+<span id="cb14-43"><a href="#cb14-43"></a>npch <span class="ot">&lt;-</span> <span class="dv">1</span><span class="sc">:</span><span class="dv">25</span></span>
+<span id="cb14-44"><a href="#cb14-44"></a>npatients <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(adlb<span class="sc">$</span>SUBJID))</span>
+<span id="cb14-45"><a href="#cb14-45"></a>pch <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb14-46"><a href="#cb14-46"></a>  <span class="fu">rep</span>(npch, <span class="at">times =</span> npatients <span class="sc">%/%</span> <span class="fu">length</span>(npch)),</span>
+<span id="cb14-47"><a href="#cb14-47"></a>  npch[<span class="dv">1</span><span class="sc">:</span>(npatients <span class="sc">%%</span> <span class="fu">length</span>(npch))]</span>
+<span id="cb14-48"><a href="#cb14-48"></a>)</span>
+<span id="cb14-49"><a href="#cb14-49"></a></span>
+<span id="cb14-50"><a href="#cb14-50"></a><span class="co"># Add the mean along with the 95% CI at every visit.</span></span>
+<span id="cb14-51"><a href="#cb14-51"></a>mean_95_text <span class="ot">&lt;-</span> <span class="st">"Mean +/- 95% CI"</span></span>
+<span id="cb14-52"><a href="#cb14-52"></a><span class="co"># Add the median and 95% CI as follows.</span></span>
+<span id="cb14-53"><a href="#cb14-53"></a>median_95_text <span class="ot">&lt;-</span> <span class="st">"Median +/- 95% CI"</span></span>
+<span id="cb14-54"><a href="#cb14-54"></a><span class="co"># Add the median and 95% CI as follows.</span></span>
+<span id="cb14-55"><a href="#cb14-55"></a>median_80_text <span class="ot">&lt;-</span> <span class="st">"Median +/- 80% CI"</span></span>
+<span id="cb14-56"><a href="#cb14-56"></a><span class="in">```</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a></span>
+<span id="cb14-58"><a href="#cb14-58"></a><span class="fu">## Plot of Liver Function Tests</span></span>
+<span id="cb14-59"><a href="#cb14-59"></a></span>
+<span id="cb14-60"><a href="#cb14-60"></a><span class="fu">#### Basic Plot</span></span>
+<span id="cb14-61"><a href="#cb14-61"></a></span>
+<span id="cb14-62"><a href="#cb14-62"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a><span class="co"># General mapping and "lattice" ("facet" in ggplot2 nomenclature).</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a>g1 <span class="ot">&lt;-</span> {</span>
+<span id="cb14-65"><a href="#cb14-65"></a>  <span class="fu">ggplot</span>(</span>
+<span id="cb14-66"><a href="#cb14-66"></a>    <span class="at">data =</span> adlb,</span>
+<span id="cb14-67"><a href="#cb14-67"></a>    <span class="at">mapping =</span> <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">colour =</span> SUBJID, <span class="at">shape =</span> SUBJID)</span>
+<span id="cb14-68"><a href="#cb14-68"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="fu">facet_grid</span>(LBTESTCD <span class="sc">~</span> ARM, <span class="at">scales =</span> <span class="st">"free_y"</span>) <span class="sc">+</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a>    <span class="fu">scale_shape_manual</span>(<span class="at">values =</span> pch)</span>
+<span id="cb14-71"><a href="#cb14-71"></a>}</span>
+<span id="cb14-72"><a href="#cb14-72"></a></span>
+<span id="cb14-73"><a href="#cb14-73"></a><span class="co"># Add points and lines.</span></span>
+<span id="cb14-74"><a href="#cb14-74"></a>g1 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">geom_point</span>()</span>
+<span id="cb14-75"><a href="#cb14-75"></a>g1 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">geom_line</span>()</span>
+<span id="cb14-76"><a href="#cb14-76"></a>plot <span class="ot">&lt;-</span> g1</span>
+<span id="cb14-77"><a href="#cb14-77"></a>plot</span>
+<span id="cb14-78"><a href="#cb14-78"></a><span class="in">```</span></span>
+<span id="cb14-79"><a href="#cb14-79"></a></span>
+<span id="cb14-80"><a href="#cb14-80"></a><span class="fu">#### Modifying Facets</span></span>
+<span id="cb14-81"><a href="#cb14-81"></a></span>
+<span id="cb14-82"><a href="#cb14-82"></a>The units describing rows of panes and the number of patients under each arm is specified by modifying <span class="in">`facet_grid()`</span>:</span>
+<span id="cb14-83"><a href="#cb14-83"></a></span>
+<span id="cb14-84"><a href="#cb14-84"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb14-85"><a href="#cb14-85"></a><span class="co"># Include the units and the sample size N.</span></span>
+<span id="cb14-86"><a href="#cb14-86"></a>g2 <span class="ot">&lt;-</span> g1 <span class="sc">+</span> <span class="fu">facet_grid</span>(</span>
+<span id="cb14-87"><a href="#cb14-87"></a>  <span class="fu">paste0</span>(LBTESTCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">")"</span>) <span class="sc">~</span> ARM_N,</span>
+<span id="cb14-88"><a href="#cb14-88"></a>  <span class="at">scales =</span> <span class="st">"free_y"</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a>)</span>
+<span id="cb14-90"><a href="#cb14-90"></a></span>
+<span id="cb14-91"><a href="#cb14-91"></a>plot <span class="ot">&lt;-</span> g2</span>
+<span id="cb14-92"><a href="#cb14-92"></a>plot</span>
+<span id="cb14-93"><a href="#cb14-93"></a><span class="in">```</span></span>
+<span id="cb14-94"><a href="#cb14-94"></a></span>
+<span id="cb14-95"><a href="#cb14-95"></a><span class="fu">#### Modifying X-Axis</span></span>
+<span id="cb14-96"><a href="#cb14-96"></a></span>
+<span id="cb14-97"><a href="#cb14-97"></a>The graphic elements are modified through usual <span class="in">`ggplot2`</span> functions.</span>
+<span id="cb14-98"><a href="#cb14-98"></a>For instance, the x-axis could be improved as follows:</span>
+<span id="cb14-99"><a href="#cb14-99"></a></span>
+<span id="cb14-100"><a href="#cb14-100"></a><span class="in">```{r plot3, test = list(plot_v3 = "g3")}</span></span>
+<span id="cb14-101"><a href="#cb14-101"></a>g3 <span class="ot">&lt;-</span> g2 <span class="sc">+</span> <span class="fu">theme</span>(</span>
+<span id="cb14-102"><a href="#cb14-102"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_text</span>(<span class="at">angle =</span> <span class="dv">45</span>, <span class="at">hjust =</span> <span class="dv">1</span>),</span>
+<span id="cb14-103"><a href="#cb14-103"></a>  <span class="at">axis.title =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb14-104"><a href="#cb14-104"></a>) <span class="sc">+</span> <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> adlb<span class="sc">$</span>AVISIT, <span class="at">labels =</span> adlb<span class="sc">$</span>AVISIT_txt)</span>
+<span id="cb14-105"><a href="#cb14-105"></a></span>
+<span id="cb14-106"><a href="#cb14-106"></a>plot <span class="ot">&lt;-</span> g3</span>
+<span id="cb14-107"><a href="#cb14-107"></a>plot</span>
+<span id="cb14-108"><a href="#cb14-108"></a><span class="in">```</span></span>
+<span id="cb14-109"><a href="#cb14-109"></a></span>
+<span id="cb14-110"><a href="#cb14-110"></a><span class="fu">## Plot of Liver Function Tests &lt;br/&gt; Including Mean, Median, and 95% CIs</span></span>
+<span id="cb14-111"><a href="#cb14-111"></a></span>
+<span id="cb14-112"><a href="#cb14-112"></a>The functions <span class="in">`stat_mean_ci`</span> and <span class="in">`stat_median_ci`</span> from the <span class="in">`tern`</span> package allow the addition of mean and/or median confidence intervals.</span>
+<span id="cb14-113"><a href="#cb14-113"></a>The example below suggests a larger dataset, where the individual subject legend may not be relevant but the mean or the median are of special interest.</span>
+<span id="cb14-114"><a href="#cb14-114"></a></span>
+<span id="cb14-115"><a href="#cb14-115"></a><span class="fu">#### Pre-Processing</span></span>
+<span id="cb14-116"><a href="#cb14-116"></a></span>
+<span id="cb14-117"><a href="#cb14-117"></a><span class="in">```{r pre-processing}</span></span>
+<span id="cb14-118"><a href="#cb14-118"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-119"><a href="#cb14-119"></a></span>
+<span id="cb14-120"><a href="#cb14-120"></a><span class="co"># Datasets</span></span>
+<span id="cb14-121"><a href="#cb14-121"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span> <span class="fu">slice</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">40</span>)</span>
+<span id="cb14-122"><a href="#cb14-122"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(USUBJID <span class="sc">%in%</span> adsl<span class="sc">$</span>USUBJID)</span>
+<span id="cb14-123"><a href="#cb14-123"></a></span>
+<span id="cb14-124"><a href="#cb14-124"></a><span class="co"># Pre-processing</span></span>
+<span id="cb14-125"><a href="#cb14-125"></a>adlb<span class="sc">$</span>AVISIT_txt <span class="ot">&lt;-</span> adlb<span class="sc">$</span>AVISIT</span>
+<span id="cb14-126"><a href="#cb14-126"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb14-127"><a href="#cb14-127"></a>adlb<span class="sc">$</span>ARM_N <span class="ot">&lt;-</span> adlb<span class="sc">$</span>ARM</span>
+<span id="cb14-128"><a href="#cb14-128"></a><span class="fu">levels</span>(adlb<span class="sc">$</span>ARM_N) <span class="ot">&lt;-</span> <span class="fu">with</span>(</span>
+<span id="cb14-129"><a href="#cb14-129"></a>  <span class="at">data =</span> adlb,</span>
+<span id="cb14-130"><a href="#cb14-130"></a>  <span class="fu">paste0</span>(</span>
+<span id="cb14-131"><a href="#cb14-131"></a>    <span class="fu">levels</span>(ARM_N), <span class="st">" (N = "</span>,</span>
+<span id="cb14-132"><a href="#cb14-132"></a>    <span class="fu">tapply</span>(SUBJID, ARM_N, <span class="cf">function</span>(x) <span class="fu">length</span>(<span class="fu">unique</span>(x))), <span class="st">")"</span></span>
+<span id="cb14-133"><a href="#cb14-133"></a>  )</span>
+<span id="cb14-134"><a href="#cb14-134"></a>)</span>
+<span id="cb14-135"><a href="#cb14-135"></a></span>
+<span id="cb14-136"><a href="#cb14-136"></a><span class="co"># Plot utils</span></span>
+<span id="cb14-137"><a href="#cb14-137"></a>npch <span class="ot">&lt;-</span> <span class="dv">1</span><span class="sc">:</span><span class="dv">25</span></span>
+<span id="cb14-138"><a href="#cb14-138"></a>npatients <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(adlb<span class="sc">$</span>SUBJID))</span>
+<span id="cb14-139"><a href="#cb14-139"></a>pch <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb14-140"><a href="#cb14-140"></a>  <span class="fu">rep</span>(npch, <span class="at">times =</span> npatients <span class="sc">%/%</span> <span class="fu">length</span>(npch)),</span>
+<span id="cb14-141"><a href="#cb14-141"></a>  npch[<span class="dv">1</span><span class="sc">:</span>(npatients <span class="sc">%%</span> <span class="fu">length</span>(npch))]</span>
+<span id="cb14-142"><a href="#cb14-142"></a>)</span>
+<span id="cb14-143"><a href="#cb14-143"></a><span class="in">```</span></span>
+<span id="cb14-144"><a href="#cb14-144"></a></span>
+<span id="cb14-145"><a href="#cb14-145"></a><span class="fu">#### Basic Plot</span></span>
+<span id="cb14-146"><a href="#cb14-146"></a></span>
+<span id="cb14-147"><a href="#cb14-147"></a><span class="in">```{r plot4, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb14-148"><a href="#cb14-148"></a><span class="co"># General mapping and "lattice" ("facet" in ggplot2 nomenclature)</span></span>
+<span id="cb14-149"><a href="#cb14-149"></a>g4 <span class="ot">&lt;-</span> {</span>
+<span id="cb14-150"><a href="#cb14-150"></a>  <span class="fu">ggplot</span>(</span>
+<span id="cb14-151"><a href="#cb14-151"></a>    <span class="at">data =</span> adlb,</span>
+<span id="cb14-152"><a href="#cb14-152"></a>    <span class="at">mapping =</span> <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">colour =</span> SUBJID, <span class="at">shape =</span> SUBJID)</span>
+<span id="cb14-153"><a href="#cb14-153"></a>  ) <span class="sc">+</span></span>
+<span id="cb14-154"><a href="#cb14-154"></a>    <span class="fu">facet_grid</span>(LBTESTCD <span class="sc">~</span> ARM_N, <span class="at">scales =</span> <span class="st">"free_y"</span>) <span class="sc">+</span></span>
+<span id="cb14-155"><a href="#cb14-155"></a>    <span class="fu">scale_shape_manual</span>(<span class="at">values =</span> pch) <span class="sc">+</span></span>
+<span id="cb14-156"><a href="#cb14-156"></a>    <span class="fu">scale_color_manual</span>(<span class="at">values =</span> <span class="fu">rep</span>(<span class="fu">getOption</span>(<span class="st">"ggplot2.discrete.colour"</span>), <span class="dv">2</span>))</span>
+<span id="cb14-157"><a href="#cb14-157"></a>}</span>
+<span id="cb14-158"><a href="#cb14-158"></a></span>
+<span id="cb14-159"><a href="#cb14-159"></a><span class="co"># Add points and lines.</span></span>
+<span id="cb14-160"><a href="#cb14-160"></a><span class="co"># Note that with so many patients, legend might not be useful and transparency</span></span>
+<span id="cb14-161"><a href="#cb14-161"></a><span class="co">#   is advisable.</span></span>
+<span id="cb14-162"><a href="#cb14-162"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">geom_point</span>(<span class="at">alpha =</span> .<span class="dv">3</span>)</span>
+<span id="cb14-163"><a href="#cb14-163"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">geom_line</span>(<span class="at">alpha =</span> .<span class="dv">3</span>)</span>
+<span id="cb14-164"><a href="#cb14-164"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">guides</span>(<span class="at">colour =</span> <span class="st">"none"</span>, <span class="at">shape =</span> <span class="st">"none"</span>)</span>
+<span id="cb14-165"><a href="#cb14-165"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">theme</span>(</span>
+<span id="cb14-166"><a href="#cb14-166"></a>  <span class="at">axis.text.x =</span> <span class="fu">element_text</span>(<span class="at">angle =</span> <span class="dv">45</span>, <span class="at">hjust =</span> <span class="dv">1</span>),</span>
+<span id="cb14-167"><a href="#cb14-167"></a>  <span class="at">axis.title  =</span> <span class="fu">element_blank</span>()</span>
+<span id="cb14-168"><a href="#cb14-168"></a>)</span>
+<span id="cb14-169"><a href="#cb14-169"></a>g4 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> adlb<span class="sc">$</span>AVISIT, <span class="at">labels =</span> adlb<span class="sc">$</span>AVISIT_txt)</span>
+<span id="cb14-170"><a href="#cb14-170"></a>plot <span class="ot">&lt;-</span> g4</span>
+<span id="cb14-171"><a href="#cb14-171"></a>plot</span>
+<span id="cb14-172"><a href="#cb14-172"></a><span class="in">```</span></span>
+<span id="cb14-173"><a href="#cb14-173"></a></span>
+<span id="cb14-174"><a href="#cb14-174"></a><span class="fu">#### Adding Mean</span></span>
+<span id="cb14-175"><a href="#cb14-175"></a></span>
+<span id="cb14-176"><a href="#cb14-176"></a><span class="in">```{r plot51, test = list(plot_v51 = "plot")}</span></span>
+<span id="cb14-177"><a href="#cb14-177"></a>g51 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-178"><a href="#cb14-178"></a>  <span class="at">fun =</span> mean, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb14-179"><a href="#cb14-179"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> mean_95_text)</span>
+<span id="cb14-180"><a href="#cb14-180"></a>)</span>
+<span id="cb14-181"><a href="#cb14-181"></a>g51 <span class="ot">&lt;-</span> g51 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-182"><a href="#cb14-182"></a>  <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_mean_ci, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-183"><a href="#cb14-183"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> mean_95_text)</span>
+<span id="cb14-184"><a href="#cb14-184"></a>)</span>
+<span id="cb14-185"><a href="#cb14-185"></a>plot <span class="ot">&lt;-</span> g51</span>
+<span id="cb14-186"><a href="#cb14-186"></a>plot</span>
+<span id="cb14-187"><a href="#cb14-187"></a><span class="in">```</span></span>
+<span id="cb14-188"><a href="#cb14-188"></a></span>
+<span id="cb14-189"><a href="#cb14-189"></a><span class="fu">#### Adding Median</span></span>
+<span id="cb14-190"><a href="#cb14-190"></a></span>
+<span id="cb14-191"><a href="#cb14-191"></a><span class="in">```{r plot52, test = list(plot_v52 = "plot")}</span></span>
+<span id="cb14-192"><a href="#cb14-192"></a><span class="co"># Instead of a mean, the median could be more relevant.</span></span>
+<span id="cb14-193"><a href="#cb14-193"></a>g52 <span class="ot">&lt;-</span> g51 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-194"><a href="#cb14-194"></a>  <span class="at">fun =</span> median, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb14-195"><a href="#cb14-195"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_95_text)</span>
+<span id="cb14-196"><a href="#cb14-196"></a>)</span>
+<span id="cb14-197"><a href="#cb14-197"></a>g52 <span class="ot">&lt;-</span> g52 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-198"><a href="#cb14-198"></a>  <span class="at">fun.data =</span> tern<span class="sc">::</span>stat_median_ci, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb14-199"><a href="#cb14-199"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_95_text)</span>
+<span id="cb14-200"><a href="#cb14-200"></a>)</span>
+<span id="cb14-201"><a href="#cb14-201"></a>plot <span class="ot">&lt;-</span> g52 <span class="sc">+</span> <span class="fu">guides</span>(<span class="at">linetype =</span> <span class="fu">guide_legend</span>(<span class="at">title =</span> <span class="st">"Aggregate"</span>))</span>
+<span id="cb14-202"><a href="#cb14-202"></a>plot</span>
+<span id="cb14-203"><a href="#cb14-203"></a><span class="in">```</span></span>
+<span id="cb14-204"><a href="#cb14-204"></a></span>
+<span id="cb14-205"><a href="#cb14-205"></a><span class="fu">#### Changing Confidence Level</span></span>
+<span id="cb14-206"><a href="#cb14-206"></a></span>
+<span id="cb14-207"><a href="#cb14-207"></a><span class="in">```{r plot53, test = list(plot_v53 = "plot")}</span></span>
+<span id="cb14-208"><a href="#cb14-208"></a><span class="co"># Change the confidence level of interval for the median.</span></span>
+<span id="cb14-209"><a href="#cb14-209"></a><span class="co"># Note: check `?stat_mean_ci()` and `?stat_median_ci()` for further fine tuning.</span></span>
+<span id="cb14-210"><a href="#cb14-210"></a>g53 <span class="ot">&lt;-</span> g4 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-211"><a href="#cb14-211"></a>  <span class="at">fun =</span> median, <span class="at">linewidth =</span> <span class="dv">1</span>, <span class="at">geom =</span> <span class="st">"line"</span>,</span>
+<span id="cb14-212"><a href="#cb14-212"></a>  <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_80_text)</span>
+<span id="cb14-213"><a href="#cb14-213"></a>)</span>
+<span id="cb14-214"><a href="#cb14-214"></a>g53 <span class="ot">&lt;-</span> g53 <span class="sc">+</span> <span class="fu">stat_summary</span>(</span>
+<span id="cb14-215"><a href="#cb14-215"></a>  <span class="at">fun.data =</span> <span class="cf">function</span>(x) tern<span class="sc">::</span><span class="fu">stat_median_ci</span>(x, <span class="at">conf_level =</span> <span class="fl">0.8</span>),</span>
+<span id="cb14-216"><a href="#cb14-216"></a>  <span class="at">geom =</span> <span class="st">"errorbar"</span>, <span class="fu">aes</span>(<span class="at">group =</span> <span class="dv">1</span>, <span class="at">linetype =</span> median_80_text)</span>
+<span id="cb14-217"><a href="#cb14-217"></a>)</span>
+<span id="cb14-218"><a href="#cb14-218"></a>plot <span class="ot">&lt;-</span> g53</span>
+<span id="cb14-219"><a href="#cb14-219"></a>plot</span>
+<span id="cb14-220"><a href="#cb14-220"></a><span class="in">```</span></span>
+<span id="cb14-221"><a href="#cb14-221"></a></span>
+<span id="cb14-222"><a href="#cb14-222"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-223"><a href="#cb14-223"></a></span>
+<span id="cb14-224"><a href="#cb14-224"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-225"><a href="#cb14-225"></a></span>
+<span id="cb14-226"><a href="#cb14-226"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-227"><a href="#cb14-227"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-228"><a href="#cb14-228"></a></span>
+<span id="cb14-229"><a href="#cb14-229"></a><span class="co"># In progress</span></span>
+<span id="cb14-230"><a href="#cb14-230"></a><span class="in">```</span></span>
+<span id="cb14-231"><a href="#cb14-231"></a></span>
+<span id="cb14-232"><a href="#cb14-232"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-233"><a href="#cb14-233"></a></span>
+<span id="cb14-234"><a href="#cb14-234"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+ <span class="menu-text">Concomitant Medications</span></a>
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+ <span class="menu-text">DMT01</span></a>
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+ <span class="menu-text">Disposition</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
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+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MNG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Mean Plot</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of Mean <br> and CI</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot of Mean and CIs of Change <br> from Baseline (Changing the Input <br> Analysis Data Set and Analysis Variable)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot of Mean (+/-SD) <br> (Changing the Statistics)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Plot of Mean and CI <br> (Modify Alpha Level)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Plot of Mean and CI (with Number <br> of Patients only in Table Section)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Plot of Mean and CI <br> (with Table Section)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Plot of Median and CI (Visits <br> Condensed in Table Section)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Plot of Mean and <br> Upper Confidence Limit</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mng01_cache/html/setup_80a9c5e42824911d430b305252c564d6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a>advs_f <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DIABP"</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">df_explicit_na</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot1_ff7d60639ec1e41554eeb6732d9cd1c3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot2_61b976e9e34d11fd486e6b36ac990c82">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="at">df =</span> advs_f,</span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(<span class="at">y =</span> <span class="st">"CHG"</span>),</span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean and 95% Confidence Intervals of Change from Baseline by Visit"</span>,</span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="at">subtitle =</span> <span class="st">"Assessment:"</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>)</span>
+<span id="cb3-8"><a href="#cb3-8"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot3_754267c7d189a103dc25e2320bd12b1d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean (+/-SD)"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>)</span>
+<span id="cb4-9"><a href="#cb4-9"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot4_6396b9bceb587b07a1e420fc3cb4860d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="at">control =</span> <span class="fu">control_analyze_vars</span>(<span class="at">conf_level =</span> <span class="fl">0.80</span>),</span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean and 80% Confidence Limits by Visit"</span>,</span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>)</span>
+<span id="cb5-8"><a href="#cb5-8"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;plot_v5&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot5_6cd3557988832f3cb6745908b9eb2e13">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="at">table =</span> <span class="st">"n"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot5-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;plot_v6&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot6_2d1a5bfbe226127757873b2f417f27a9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb7-4"><a href="#cb7-4"></a>  <span class="at">table =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"mean_ci"</span>),</span>
+<span id="cb7-5"><a href="#cb7-5"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb7-6"><a href="#cb7-6"></a>)</span>
+<span id="cb7-7"><a href="#cb7-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot6-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<p>This option is not supported.</p>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<div class="cell" data-test="{&quot;plot_v7&quot;:&quot;plot&quot;}" data-hash="mng01_cache/html/plot7_701cd2988c9f5bc9af55acdee18aa3be">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">whiskers =</span> <span class="st">"mean_ci_upr"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>)</span>
+<span id="cb8-7"><a href="#cb8-7"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/plot7-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="mng01_cache/html/teal_7d9ef3747b719cbaea50cab1f1783e19">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb9-4"><a href="#cb9-4"></a></span>
+<span id="cb9-5"><a href="#cb9-5"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-6"><a href="#cb9-6"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-7"><a href="#cb9-7"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min))</span>
+<span id="cb9-8"><a href="#cb9-8"></a></span>
+<span id="cb9-9"><a href="#cb9-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb9-11"><a href="#cb9-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb9-12"><a href="#cb9-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB, <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="st">                    mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min))'</span>),</span>
+<span id="cb9-14"><a href="#cb9-14"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a>  ),</span>
+<span id="cb9-16"><a href="#cb9-16"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb9-17"><a href="#cb9-17"></a>    <span class="fu">tm_g_lineplot</span>(</span>
+<span id="cb9-18"><a href="#cb9-18"></a>      <span class="at">label =</span> <span class="st">"LINE PLOT"</span>,</span>
+<span id="cb9-19"><a href="#cb9-19"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb9-20"><a href="#cb9-20"></a>      <span class="at">strata =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-21"><a href="#cb9-21"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb9-22"><a href="#cb9-22"></a>        <span class="st">"ARM"</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>      ),</span>
+<span id="cb9-24"><a href="#cb9-24"></a>      <span class="at">y =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>        <span class="fu">variable_choices</span>(ADLB, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"BASE"</span>, <span class="st">"CHG"</span>, <span class="st">"PCHG"</span>)),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>        <span class="st">"AVAL"</span></span>
+<span id="cb9-27"><a href="#cb9-27"></a>      ),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>      <span class="at">param =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-29"><a href="#cb9-29"></a>        <span class="fu">value_choices</span>(ADLB, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb9-30"><a href="#cb9-30"></a>        <span class="st">"ALT"</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>      )</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    )</span>
+<span id="cb9-33"><a href="#cb9-33"></a>  )</span>
+<span id="cb9-34"><a href="#cb9-34"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:54:18.9714 pid:6758 token:[] teal.modules.clinical Initializing tm_g_lineplot</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mng01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mng01_cache/html/sessioninfo_2aed547e490732fe45c7df71863a11ed">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] nestcolor_0.1.2              scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        
+ [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        
+ [7] digest_0.6.33         estimability_1.4.1    mime_0.12            
+[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       
+[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       
+[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          
+[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           
+[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      
+[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   
+[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[34] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[37] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[40] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[43] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[49] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[52] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[55] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[58] ps_1.7.5              codetools_0.2-19      cowplot_1.1.1        
+[61] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[64] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[67] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[70] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[73] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[76] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[79] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          
+[82] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[85] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[88] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mng01_cache/html/snapshot_9c6d3e0df49a5ed4654acdf5a9a8b457">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/other/mng01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+    placement: 'right',
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+      }
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/other/ltg01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LTG01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/pharmacokinetic/pkcg01.html" class="pagination-link">
+        <span class="nav-page-text">PKCG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> MNG01</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Mean Plot</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>::: panel-tabset</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-14"><a href="#cb15-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a></span>
+<span id="cb15-16"><a href="#cb15-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-17"><a href="#cb15-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb15-18"><a href="#cb15-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-19"><a href="#cb15-19"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb15-20"><a href="#cb15-20"></a></span>
+<span id="cb15-21"><a href="#cb15-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-22"><a href="#cb15-22"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb15-23"><a href="#cb15-23"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb15-24"><a href="#cb15-24"></a></span>
+<span id="cb15-25"><a href="#cb15-25"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb15-26"><a href="#cb15-26"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-27"><a href="#cb15-27"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb15-28"><a href="#cb15-28"></a></span>
+<span id="cb15-29"><a href="#cb15-29"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb15-30"><a href="#cb15-30"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-31"><a href="#cb15-31"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb15-32"><a href="#cb15-32"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb15-33"><a href="#cb15-33"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb15-34"><a href="#cb15-34"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb15-35"><a href="#cb15-35"></a>    PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>,</span>
+<span id="cb15-36"><a href="#cb15-36"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb15-37"><a href="#cb15-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-38"><a href="#cb15-38"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-39"><a href="#cb15-39"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb15-40"><a href="#cb15-40"></a></span>
+<span id="cb15-41"><a href="#cb15-41"></a>advs_f <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb15-42"><a href="#cb15-42"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb15-44"><a href="#cb15-44"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb15-45"><a href="#cb15-45"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb15-46"><a href="#cb15-46"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DIABP"</span>,</span>
+<span id="cb15-47"><a href="#cb15-47"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb15-48"><a href="#cb15-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-49"><a href="#cb15-49"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-50"><a href="#cb15-50"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb15-51"><a href="#cb15-51"></a><span class="in">```</span></span>
+<span id="cb15-52"><a href="#cb15-52"></a></span>
+<span id="cb15-53"><a href="#cb15-53"></a><span class="fu">## Plot of Mean &lt;br/&gt; and CI</span></span>
+<span id="cb15-54"><a href="#cb15-54"></a></span>
+<span id="cb15-55"><a href="#cb15-55"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb15-56"><a href="#cb15-56"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-57"><a href="#cb15-57"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-58"><a href="#cb15-58"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-59"><a href="#cb15-59"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-60"><a href="#cb15-60"></a>)</span>
+<span id="cb15-61"><a href="#cb15-61"></a>plot</span>
+<span id="cb15-62"><a href="#cb15-62"></a><span class="in">```</span></span>
+<span id="cb15-63"><a href="#cb15-63"></a></span>
+<span id="cb15-64"><a href="#cb15-64"></a><span class="fu">## Plot of Mean and CIs of Change &lt;br/&gt; from Baseline (Changing the Input &lt;br/&gt; Analysis Data Set and Analysis Variable)</span></span>
+<span id="cb15-65"><a href="#cb15-65"></a></span>
+<span id="cb15-66"><a href="#cb15-66"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb15-67"><a href="#cb15-67"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-68"><a href="#cb15-68"></a>  <span class="at">df =</span> advs_f,</span>
+<span id="cb15-69"><a href="#cb15-69"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-70"><a href="#cb15-70"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(<span class="at">y =</span> <span class="st">"CHG"</span>),</span>
+<span id="cb15-71"><a href="#cb15-71"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean and 95% Confidence Intervals of Change from Baseline by Visit"</span>,</span>
+<span id="cb15-72"><a href="#cb15-72"></a>  <span class="at">subtitle =</span> <span class="st">"Assessment:"</span></span>
+<span id="cb15-73"><a href="#cb15-73"></a>)</span>
+<span id="cb15-74"><a href="#cb15-74"></a>plot</span>
+<span id="cb15-75"><a href="#cb15-75"></a><span class="in">```</span></span>
+<span id="cb15-76"><a href="#cb15-76"></a></span>
+<span id="cb15-77"><a href="#cb15-77"></a><span class="fu">## Plot of Mean (+/-SD) &lt;br/&gt; (Changing the Statistics)</span></span>
+<span id="cb15-78"><a href="#cb15-78"></a></span>
+<span id="cb15-79"><a href="#cb15-79"></a><span class="in">```{r plot3, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb15-80"><a href="#cb15-80"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-81"><a href="#cb15-81"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-82"><a href="#cb15-82"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-83"><a href="#cb15-83"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb15-84"><a href="#cb15-84"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb15-85"><a href="#cb15-85"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean (+/-SD)"</span>,</span>
+<span id="cb15-86"><a href="#cb15-86"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-87"><a href="#cb15-87"></a>)</span>
+<span id="cb15-88"><a href="#cb15-88"></a>plot</span>
+<span id="cb15-89"><a href="#cb15-89"></a><span class="in">```</span></span>
+<span id="cb15-90"><a href="#cb15-90"></a></span>
+<span id="cb15-91"><a href="#cb15-91"></a><span class="fu">## Plot of Mean and CI &lt;br/&gt; (Modify Alpha Level)</span></span>
+<span id="cb15-92"><a href="#cb15-92"></a></span>
+<span id="cb15-93"><a href="#cb15-93"></a><span class="in">```{r plot4, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb15-94"><a href="#cb15-94"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-95"><a href="#cb15-95"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-96"><a href="#cb15-96"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-97"><a href="#cb15-97"></a>  <span class="at">control =</span> <span class="fu">control_analyze_vars</span>(<span class="at">conf_level =</span> <span class="fl">0.80</span>),</span>
+<span id="cb15-98"><a href="#cb15-98"></a>  <span class="at">title =</span> <span class="st">"Plot of Mean and 80% Confidence Limits by Visit"</span>,</span>
+<span id="cb15-99"><a href="#cb15-99"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-100"><a href="#cb15-100"></a>)</span>
+<span id="cb15-101"><a href="#cb15-101"></a>plot</span>
+<span id="cb15-102"><a href="#cb15-102"></a><span class="in">```</span></span>
+<span id="cb15-103"><a href="#cb15-103"></a></span>
+<span id="cb15-104"><a href="#cb15-104"></a><span class="fu">## Plot of Mean and CI (with Number &lt;br/&gt; of Patients only in Table Section)</span></span>
+<span id="cb15-105"><a href="#cb15-105"></a></span>
+<span id="cb15-106"><a href="#cb15-106"></a><span class="in">```{r plot5, test = list(plot_v5 = "plot")}</span></span>
+<span id="cb15-107"><a href="#cb15-107"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-108"><a href="#cb15-108"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-109"><a href="#cb15-109"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-110"><a href="#cb15-110"></a>  <span class="at">table =</span> <span class="st">"n"</span>,</span>
+<span id="cb15-111"><a href="#cb15-111"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-112"><a href="#cb15-112"></a>)</span>
+<span id="cb15-113"><a href="#cb15-113"></a>plot</span>
+<span id="cb15-114"><a href="#cb15-114"></a><span class="in">```</span></span>
+<span id="cb15-115"><a href="#cb15-115"></a></span>
+<span id="cb15-116"><a href="#cb15-116"></a><span class="fu">## Plot of Mean and CI &lt;br/&gt; (with Table Section)</span></span>
+<span id="cb15-117"><a href="#cb15-117"></a></span>
+<span id="cb15-118"><a href="#cb15-118"></a><span class="in">```{r plot6, fig.height = 8, test = list(plot_v6 = "plot")}</span></span>
+<span id="cb15-119"><a href="#cb15-119"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-120"><a href="#cb15-120"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-121"><a href="#cb15-121"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-122"><a href="#cb15-122"></a>  <span class="at">table =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"mean_ci"</span>),</span>
+<span id="cb15-123"><a href="#cb15-123"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-124"><a href="#cb15-124"></a>)</span>
+<span id="cb15-125"><a href="#cb15-125"></a>plot</span>
+<span id="cb15-126"><a href="#cb15-126"></a><span class="in">```</span></span>
+<span id="cb15-127"><a href="#cb15-127"></a></span>
+<span id="cb15-128"><a href="#cb15-128"></a><span class="fu">## Plot of Median and CI (Visits &lt;br/&gt; Condensed in Table Section)</span></span>
+<span id="cb15-129"><a href="#cb15-129"></a></span>
+<span id="cb15-130"><a href="#cb15-130"></a>This option is not supported.</span>
+<span id="cb15-131"><a href="#cb15-131"></a></span>
+<span id="cb15-132"><a href="#cb15-132"></a><span class="fu">## Plot of Mean and &lt;br/&gt; Upper Confidence Limit</span></span>
+<span id="cb15-133"><a href="#cb15-133"></a></span>
+<span id="cb15-134"><a href="#cb15-134"></a><span class="in">```{r plot7, test = list(plot_v7 = "plot")}</span></span>
+<span id="cb15-135"><a href="#cb15-135"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb15-136"><a href="#cb15-136"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb15-137"><a href="#cb15-137"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb15-138"><a href="#cb15-138"></a>  <span class="at">whiskers =</span> <span class="st">"mean_ci_upr"</span>,</span>
+<span id="cb15-139"><a href="#cb15-139"></a>  <span class="at">subtitle =</span> <span class="st">"Laboratory Test:"</span></span>
+<span id="cb15-140"><a href="#cb15-140"></a>)</span>
+<span id="cb15-141"><a href="#cb15-141"></a>plot</span>
+<span id="cb15-142"><a href="#cb15-142"></a><span class="in">```</span></span>
+<span id="cb15-143"><a href="#cb15-143"></a></span>
+<span id="cb15-144"><a href="#cb15-144"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-145"><a href="#cb15-145"></a></span>
+<span id="cb15-146"><a href="#cb15-146"></a><span class="fu">## `teal` App</span></span>
+<span id="cb15-147"><a href="#cb15-147"></a></span>
+<span id="cb15-148"><a href="#cb15-148"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb15-149"><a href="#cb15-149"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb15-150"><a href="#cb15-150"></a></span>
+<span id="cb15-151"><a href="#cb15-151"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-152"><a href="#cb15-152"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-153"><a href="#cb15-153"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb15-154"><a href="#cb15-154"></a></span>
+<span id="cb15-155"><a href="#cb15-155"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-156"><a href="#cb15-156"></a>ADLB <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN, min))</span>
+<span id="cb15-158"><a href="#cb15-158"></a></span>
+<span id="cb15-159"><a href="#cb15-159"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb15-160"><a href="#cb15-160"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb15-161"><a href="#cb15-161"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb15-162"><a href="#cb15-162"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, ADLB, <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb15-163"><a href="#cb15-163"></a><span class="st">                    mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min))'</span>),</span>
+<span id="cb15-164"><a href="#cb15-164"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-165"><a href="#cb15-165"></a>  ),</span>
+<span id="cb15-166"><a href="#cb15-166"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb15-167"><a href="#cb15-167"></a>    <span class="fu">tm_g_lineplot</span>(</span>
+<span id="cb15-168"><a href="#cb15-168"></a>      <span class="at">label =</span> <span class="st">"LINE PLOT"</span>,</span>
+<span id="cb15-169"><a href="#cb15-169"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb15-170"><a href="#cb15-170"></a>      <span class="at">strata =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-171"><a href="#cb15-171"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb15-172"><a href="#cb15-172"></a>        <span class="st">"ARM"</span></span>
+<span id="cb15-173"><a href="#cb15-173"></a>      ),</span>
+<span id="cb15-174"><a href="#cb15-174"></a>      <span class="at">y =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-175"><a href="#cb15-175"></a>        <span class="fu">variable_choices</span>(ADLB, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"BASE"</span>, <span class="st">"CHG"</span>, <span class="st">"PCHG"</span>)),</span>
+<span id="cb15-176"><a href="#cb15-176"></a>        <span class="st">"AVAL"</span></span>
+<span id="cb15-177"><a href="#cb15-177"></a>      ),</span>
+<span id="cb15-178"><a href="#cb15-178"></a>      <span class="at">param =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-179"><a href="#cb15-179"></a>        <span class="fu">value_choices</span>(ADLB, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb15-180"><a href="#cb15-180"></a>        <span class="st">"ALT"</span></span>
+<span id="cb15-181"><a href="#cb15-181"></a>      )</span>
+<span id="cb15-182"><a href="#cb15-182"></a>    )</span>
+<span id="cb15-183"><a href="#cb15-183"></a>  )</span>
+<span id="cb15-184"><a href="#cb15-184"></a>)</span>
+<span id="cb15-185"><a href="#cb15-185"></a></span>
+<span id="cb15-186"><a href="#cb15-186"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb15-187"><a href="#cb15-187"></a><span class="in">```</span></span>
+<span id="cb15-188"><a href="#cb15-188"></a></span>
+<span id="cb15-189"><a href="#cb15-189"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-190"><a href="#cb15-190"></a></span>
+<span id="cb15-191"><a href="#cb15-191"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+      &nbsp;
+    </div>
+  </div>
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+
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\ No newline at end of file
diff --git a/stable/graphs/other/mng01_files/figure-html/plot1-1.png b/stable/graphs/other/mng01_files/figure-html/plot1-1.png
new file mode 100644
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+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+ <span class="menu-text">DMT01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Disclosures</span></a>
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+ <span class="menu-text">Disposition</span></a>
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+<li class="sidebar-item">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Plot of PK Concentration Over Time by Subject</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot in Linear Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot in Log Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkcg01_cache/html/setup_b7d4767aeacfe33dedf18de4d622cf7b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkcg01_cache/html/plot1_dbd421b8d5c301ceb391de6323c31f6f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">filter</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by</span><span class="sc">\n</span><span class="st">Patient: PK Evaluable Patients"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a></span>
+<span id="cb2-12"><a href="#cb2-12"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="at">plotting_choices =</span> <span class="st">"separate_by_obs"</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>)</span>
+<span id="cb2-26"><a href="#cb2-26"></a>plot <span class="ot">&lt;-</span> result[[<span class="dv">1</span>]] <span class="co"># only show the first subject</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkcg01_cache/html/plot2_1b906e125d2fbdfdd1b10d088867bc17">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(</span>
+<span id="cb3-3"><a href="#cb3-3"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span>
+<span id="cb3-8"><a href="#cb3-8"></a></span>
+<span id="cb3-9"><a href="#cb3-9"></a>use_title2 <span class="ot">&lt;-</span> <span class="st">"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by</span><span class="sc">\n</span><span class="st">Patient: PK Evaluable Patients"</span></span>
+<span id="cb3-10"><a href="#cb3-10"></a>use_subtitle2 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb3-11"><a href="#cb3-11"></a>use_footnote2 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a></span>
+<span id="cb3-13"><a href="#cb3-13"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb3-14"><a href="#cb3-14"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb3-15"><a href="#cb3-15"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb3-16"><a href="#cb3-16"></a>  <span class="at">yvar =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb3-18"><a href="#cb3-18"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb3-19"><a href="#cb3-19"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb3-20"><a href="#cb3-20"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb3-21"><a href="#cb3-21"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb3-22"><a href="#cb3-22"></a>  <span class="at">title =</span> use_title2,</span>
+<span id="cb3-23"><a href="#cb3-23"></a>  <span class="at">subtitle =</span> use_subtitle2,</span>
+<span id="cb3-24"><a href="#cb3-24"></a>  <span class="at">caption =</span> use_footnote2,</span>
+<span id="cb3-25"><a href="#cb3-25"></a>  <span class="at">plotting_choices =</span> <span class="st">"separate_by_obs"</span></span>
+<span id="cb3-26"><a href="#cb3-26"></a>)</span>
+<span id="cb3-27"><a href="#cb3-27"></a>plot <span class="ot">&lt;-</span> result[[<span class="dv">1</span>]] <span class="sc">+</span> ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span>
+<span id="cb3-28"><a href="#cb3-28"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkcg01_cache/html/teal_bd40d184cd5dddababbc33236137b4b8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkcg01_cache/html/sessioninfo_4e49b670f7f40ef3675224b4b8cdd061">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkcg01_cache/html/snapshot_74b8e6cc5edaa09b14af29db3b3aacf1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkcg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
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+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/pharmacokinetic/pkcg02.html" class="pagination-link">
+        <span class="nav-page-text">PKCG02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKCG01</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Plot of PK Concentration Over Time by Subject</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a><span class="in">```</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a><span class="fu">## Plot in Linear Scale</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span>
+<span id="cb8-34"><a href="#cb8-34"></a></span>
+<span id="cb8-35"><a href="#cb8-35"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by</span><span class="sc">\n</span><span class="st">Patient: PK Evaluable Patients"</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a></span>
+<span id="cb8-39"><a href="#cb8-39"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb8-47"><a href="#cb8-47"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="at">plotting_choices =</span> <span class="st">"separate_by_obs"</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>)</span>
+<span id="cb8-53"><a href="#cb8-53"></a>plot <span class="ot">&lt;-</span> result[[<span class="dv">1</span>]] <span class="co"># only show the first subject</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>plot</span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="in">```</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a></span>
+<span id="cb8-57"><a href="#cb8-57"></a><span class="fu">## Plot in Log Scale</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a></span>
+<span id="cb8-59"><a href="#cb8-59"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID))</span>
+<span id="cb8-67"><a href="#cb8-67"></a></span>
+<span id="cb8-68"><a href="#cb8-68"></a>use_title2 <span class="ot">&lt;-</span> <span class="st">"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by</span><span class="sc">\n</span><span class="st">Patient: PK Evaluable Patients"</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a>use_subtitle2 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb8-70"><a href="#cb8-70"></a>use_footnote2 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a></span>
+<span id="cb8-72"><a href="#cb8-72"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb8-75"><a href="#cb8-75"></a>  <span class="at">yvar =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb8-76"><a href="#cb8-76"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a>  <span class="at">title =</span> use_title2,</span>
+<span id="cb8-82"><a href="#cb8-82"></a>  <span class="at">subtitle =</span> use_subtitle2,</span>
+<span id="cb8-83"><a href="#cb8-83"></a>  <span class="at">caption =</span> use_footnote2,</span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="at">plotting_choices =</span> <span class="st">"separate_by_obs"</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>)</span>
+<span id="cb8-86"><a href="#cb8-86"></a>plot <span class="ot">&lt;-</span> result[[<span class="dv">1</span>]] <span class="sc">+</span> ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span>
+<span id="cb8-87"><a href="#cb8-87"></a>plot</span>
+<span id="cb8-88"><a href="#cb8-88"></a><span class="in">```</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a></span>
+<span id="cb8-90"><a href="#cb8-90"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-91"><a href="#cb8-91"></a></span>
+<span id="cb8-92"><a href="#cb8-92"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-93"><a href="#cb8-93"></a></span>
+<span id="cb8-94"><a href="#cb8-94"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-95"><a href="#cb8-95"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a></span>
+<span id="cb8-97"><a href="#cb8-97"></a><span class="co"># In progress</span></span>
+<span id="cb8-98"><a href="#cb8-98"></a><span class="in">```</span></span>
+<span id="cb8-99"><a href="#cb8-99"></a></span>
+<span id="cb8-100"><a href="#cb8-100"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-101"><a href="#cb8-101"></a></span>
+<span id="cb8-102"><a href="#cb8-102"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCG02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Plot of PK Concentration Over Time by Cohort/Treatment Group/Dose</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot in Linear Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot in Log Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkcg02_cache/html/setup_a2fc3d3f8391bcf0d7ca2bb4a8028dd7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkcg02_cache/html/plot1_868ae1b8e14e9418e817f6b3981a7a6e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">filter</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">filter</span>(Patient_ID <span class="sc">%in%</span> <span class="fu">unique</span>(Patient_ID)[<span class="dv">1</span><span class="sc">:</span><span class="dv">10</span>])</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a>use_title1 <span class="ot">&lt;-</span> <span class="st">"Plot of X Concentration (ug/mL) Over Time by Treatment: </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>use_subtitle1 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>use_footnote1 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">title =</span> use_title1,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">subtitle =</span> use_subtitle1,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="at">caption =</span> use_footnote1,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="at">plotting_choices =</span> <span class="st">"all_in_one"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>)</span>
+<span id="cb2-27"><a href="#cb2-27"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg02_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkcg02_cache/html/plot2_1c3fa17a506905054855fb616b8a4219">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(</span>
+<span id="cb3-3"><a href="#cb3-3"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-8"><a href="#cb3-8"></a>  <span class="fu">filter</span>(Patient_ID <span class="sc">%in%</span> <span class="fu">unique</span>(Patient_ID)[<span class="dv">1</span><span class="sc">:</span><span class="dv">10</span>])</span>
+<span id="cb3-9"><a href="#cb3-9"></a></span>
+<span id="cb3-10"><a href="#cb3-10"></a>use_title3 <span class="ot">&lt;-</span> <span class="st">"Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb3-11"><a href="#cb3-11"></a>use_subtitle3 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a>use_footnote3 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb3-13"><a href="#cb3-13"></a></span>
+<span id="cb3-14"><a href="#cb3-14"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb3-15"><a href="#cb3-15"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb3-16"><a href="#cb3-16"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="at">yvar =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb3-18"><a href="#cb3-18"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb3-19"><a href="#cb3-19"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb3-20"><a href="#cb3-20"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb3-21"><a href="#cb3-21"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb3-22"><a href="#cb3-22"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb3-23"><a href="#cb3-23"></a>  <span class="at">title =</span> use_title3,</span>
+<span id="cb3-24"><a href="#cb3-24"></a>  <span class="at">caption =</span> use_footnote3,</span>
+<span id="cb3-25"><a href="#cb3-25"></a>  <span class="at">subtitle =</span> use_subtitle3,</span>
+<span id="cb3-26"><a href="#cb3-26"></a>  <span class="at">plotting_choices =</span> <span class="st">"all_in_one"</span></span>
+<span id="cb3-27"><a href="#cb3-27"></a>)</span>
+<span id="cb3-28"><a href="#cb3-28"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span>
+<span id="cb3-29"><a href="#cb3-29"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg02_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkcg02_cache/html/teal_45e549bd2197b6aeac26506e1431b4c8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkcg02_cache/html/sessioninfo_6416fc0aef7227bef747f2cfff9c7bab">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkcg02_cache/html/snapshot_568b86f8a77f8462361b244754741c92">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkcg02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/pharmacokinetic/pkcg01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKCG01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/pharmacokinetic/pkcg03.html" class="pagination-link">
+        <span class="nav-page-text">PKCG03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKCG02</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Plot of PK Concentration Over Time by Cohort/Treatment Group/Dose</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a><span class="in">```</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a><span class="fu">## Plot in Linear Scale</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="fu">filter</span>(Patient_ID <span class="sc">%in%</span> <span class="fu">unique</span>(Patient_ID)[<span class="dv">1</span><span class="sc">:</span><span class="dv">10</span>])</span>
+<span id="cb8-35"><a href="#cb8-35"></a></span>
+<span id="cb8-36"><a href="#cb8-36"></a>use_title1 <span class="ot">&lt;-</span> <span class="st">"Plot of X Concentration (ug/mL) Over Time by Treatment: </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>use_subtitle1 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>use_footnote1 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a></span>
+<span id="cb8-40"><a href="#cb8-40"></a>plot <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="at">yvar =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb8-47"><a href="#cb8-47"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>  <span class="at">title =</span> use_title1,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  <span class="at">subtitle =</span> use_subtitle1,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="at">caption =</span> use_footnote1,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>  <span class="at">plotting_choices =</span> <span class="st">"all_in_one"</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a>)</span>
+<span id="cb8-54"><a href="#cb8-54"></a>plot</span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="in">```</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a></span>
+<span id="cb8-57"><a href="#cb8-57"></a><span class="fu">## Plot in Log Scale</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a></span>
+<span id="cb8-59"><a href="#cb8-59"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>adpc_a <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>,</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    ARMCD <span class="sc">==</span> <span class="st">"ARM A"</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a>  <span class="fu">filter</span>(Patient_ID <span class="sc">%in%</span> <span class="fu">unique</span>(Patient_ID)[<span class="dv">1</span><span class="sc">:</span><span class="dv">10</span>])</span>
+<span id="cb8-68"><a href="#cb8-68"></a></span>
+<span id="cb8-69"><a href="#cb8-69"></a>use_title3 <span class="ot">&lt;-</span> <span class="st">"Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb8-70"><a href="#cb8-70"></a>use_subtitle3 <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma X (ug/mL) </span><span class="sc">\n</span><span class="st">Treatment Group: ARM A"</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a>use_footnote3 <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a>result <span class="ot">&lt;-</span> <span class="fu">g_ipp</span>(</span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="at">df =</span> adpc_a,</span>
+<span id="cb8-75"><a href="#cb8-75"></a>  <span class="at">xvar =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb8-76"><a href="#cb8-76"></a>  <span class="at">yvar =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="at">xlab =</span> <span class="st">"Norminal Time from First Dose (hr)"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>  <span class="at">ylab =</span> <span class="st">"Concentration (ug/mL)"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="at">id_var =</span> <span class="st">"Patient_ID"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>  <span class="at">add_baseline_hline =</span> F,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>  <span class="at">yvar_baseline =</span> <span class="st">"AVAL"</span>, <span class="co">#  yvar_baseline cannot be NA or ignore</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a>  <span class="at">title =</span> use_title3,</span>
+<span id="cb8-83"><a href="#cb8-83"></a>  <span class="at">caption =</span> use_footnote3,</span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="at">subtitle =</span> use_subtitle3,</span>
+<span id="cb8-85"><a href="#cb8-85"></a>  <span class="at">plotting_choices =</span> <span class="st">"all_in_one"</span></span>
+<span id="cb8-86"><a href="#cb8-86"></a>)</span>
+<span id="cb8-87"><a href="#cb8-87"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span>
+<span id="cb8-88"><a href="#cb8-88"></a>plot</span>
+<span id="cb8-89"><a href="#cb8-89"></a><span class="in">```</span></span>
+<span id="cb8-90"><a href="#cb8-90"></a></span>
+<span id="cb8-91"><a href="#cb8-91"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-92"><a href="#cb8-92"></a></span>
+<span id="cb8-93"><a href="#cb8-93"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-94"><a href="#cb8-94"></a></span>
+<span id="cb8-95"><a href="#cb8-95"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-97"><a href="#cb8-97"></a></span>
+<span id="cb8-98"><a href="#cb8-98"></a><span class="co"># In progress</span></span>
+<span id="cb8-99"><a href="#cb8-99"></a><span class="in">```</span></span>
+<span id="cb8-100"><a href="#cb8-100"></a></span>
+<span id="cb8-101"><a href="#cb8-101"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-102"><a href="#cb8-102"></a></span>
+<span id="cb8-103"><a href="#cb8-103"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
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+
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCG03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Plot of Mean PK Concentration Over Time by Cohort</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot in Linear Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot in Log Scale</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkcg03_cache/html/setup_17f312d5255faa9e3f17eb1144c5de7d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ARM <span class="sc">!=</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">df_explicit_na</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkcg03_cache/html/plot1_5984534b8fae00d56fb78ae5a8c29770">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte:"</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a></span>
+<span id="cb2-5"><a href="#cb2-5"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">df =</span> adpc,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">x =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">y_lab =</span> <span class="st">"Concentration"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>()</span>
+<span id="cb2-24"><a href="#cb2-24"></a>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>))</span>
+<span id="cb2-27"><a href="#cb2-27"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg03_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkcg03_cache/html/plot2_7617a76127576e41d45c18f52209b720">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte:"</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a></span>
+<span id="cb3-5"><a href="#cb3-5"></a>adpc <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>))</span>
+<span id="cb3-7"><a href="#cb3-7"></a></span>
+<span id="cb3-8"><a href="#cb3-8"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb3-9"><a href="#cb3-9"></a>  <span class="at">df =</span> adpc,</span>
+<span id="cb3-10"><a href="#cb3-10"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="at">x =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="at">y =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb3-13"><a href="#cb3-13"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb3-14"><a href="#cb3-14"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb3-16"><a href="#cb3-16"></a>  ),</span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb3-18"><a href="#cb3-18"></a>  <span class="at">y_lab =</span> <span class="st">"Concentration"</span>,</span>
+<span id="cb3-19"><a href="#cb3-19"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb3-20"><a href="#cb3-20"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb3-21"><a href="#cb3-21"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb3-22"><a href="#cb3-22"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb3-23"><a href="#cb3-23"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb3-24"><a href="#cb3-24"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb3-25"><a href="#cb3-25"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb3-26"><a href="#cb3-26"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>()</span>
+<span id="cb3-27"><a href="#cb3-27"></a>)</span>
+<span id="cb3-28"><a href="#cb3-28"></a></span>
+<span id="cb3-29"><a href="#cb3-29"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb3-30"><a href="#cb3-30"></a>  ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Scale for y is already present.
+Adding another scale for y, which will replace the existing scale.</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkcg03_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkcg03_cache/html/teal_eb83a57f42f3c7a9c2a6eef476c3379d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkcg03_cache/html/sessioninfo_1986d9d6694d612aa72ce04dbe22312c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   
+ [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    
+ [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       
+[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     
+[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      
+[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      
+[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 
+[29] forcats_1.0.0     broom_1.0.5       vctrs_0.6.3       R6_2.5.1         
+[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     
+[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     
+[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     
+[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  
+[49] compiler_4.3.1   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkcg03_cache/html/snapshot_1adb6f0f0f7c432a0e34902da4c0619c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkcg03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
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+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/pharmacokinetic/pkcg02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKCG02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/pharmacokinetic/pkpg01.html" class="pagination-link">
+        <span class="nav-page-text">PKPG01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> PKCG03</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Plot of Mean PK Concentration Over Time by Cohort</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb10-20"><a href="#cb10-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb10-21"><a href="#cb10-21"></a></span>
+<span id="cb10-22"><a href="#cb10-22"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ARM <span class="sc">!=</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb10-25"><a href="#cb10-25"></a></span>
+<span id="cb10-26"><a href="#cb10-26"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>  <span class="fu">mutate</span>(<span class="at">Patient_ID =</span> <span class="fu">sub</span>(<span class="st">".*id-"</span>, <span class="st">""</span>, USUBJID)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="fu">filter</span>(PARAM <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb10-31"><a href="#cb10-31"></a><span class="in">```</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a></span>
+<span id="cb10-33"><a href="#cb10-33"></a><span class="fu">## Plot in Linear Scale</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a></span>
+<span id="cb10-35"><a href="#cb10-35"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte:"</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>  <span class="at">df =</span> adpc,</span>
+<span id="cb10-42"><a href="#cb10-42"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    <span class="at">x =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  ),</span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="at">y_lab =</span> <span class="st">"Concentration"</span>,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb10-58"><a href="#cb10-58"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>()</span>
+<span id="cb10-59"><a href="#cb10-59"></a>)</span>
+<span id="cb10-60"><a href="#cb10-60"></a></span>
+<span id="cb10-61"><a href="#cb10-61"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>))</span>
+<span id="cb10-62"><a href="#cb10-62"></a>plot</span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="in">```</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="fu">## Plot in Log Scale</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="in">```{r plot2, warning=FALSE, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, </span><span class="sc">\n</span><span class="st">PK Evaluable Patients"</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte:"</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>adpc <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="fu">mutate</span>(<span class="at">avalog =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">!=</span> <span class="dv">0</span>, AVAL, <span class="fl">0.001</span>))</span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb10-76"><a href="#cb10-76"></a>  <span class="at">df =</span> adpc,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">x =</span> <span class="st">"NFRLT"</span>,</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    <span class="at">y =</span> <span class="st">"avalog"</span>,</span>
+<span id="cb10-80"><a href="#cb10-80"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb10-82"><a href="#cb10-82"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb10-83"><a href="#cb10-83"></a>  ),</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="at">alt_counts_df =</span> adsl_f,</span>
+<span id="cb10-85"><a href="#cb10-85"></a>  <span class="at">y_lab =</span> <span class="st">"Concentration"</span>,</span>
+<span id="cb10-86"><a href="#cb10-86"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-87"><a href="#cb10-87"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-88"><a href="#cb10-88"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb10-89"><a href="#cb10-89"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb10-90"><a href="#cb10-90"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb10-91"><a href="#cb10-91"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb10-92"><a href="#cb10-92"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb10-93"><a href="#cb10-93"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>()</span>
+<span id="cb10-94"><a href="#cb10-94"></a>)</span>
+<span id="cb10-95"><a href="#cb10-95"></a></span>
+<span id="cb10-96"><a href="#cb10-96"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a>  ggplot2<span class="sc">::</span><span class="fu">scale_y_log10</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>), <span class="at">label =</span> <span class="fu">c</span>(<span class="fl">0.001</span>, <span class="fl">0.01</span>, <span class="fl">0.1</span>, <span class="dv">1</span>, <span class="dv">10</span>))</span>
+<span id="cb10-98"><a href="#cb10-98"></a>plot</span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="in">```</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a></span>
+<span id="cb10-101"><a href="#cb10-101"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-102"><a href="#cb10-102"></a></span>
+<span id="cb10-103"><a href="#cb10-103"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a></span>
+<span id="cb10-105"><a href="#cb10-105"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-107"><a href="#cb10-107"></a></span>
+<span id="cb10-108"><a href="#cb10-108"></a><span class="co"># In progress</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a><span class="in">```</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a></span>
+<span id="cb10-111"><a href="#cb10-111"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-112"><a href="#cb10-112"></a></span>
+<span id="cb10-113"><a href="#cb10-113"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
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+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
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+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
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+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPG01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Plot of Mean Cumulative Percentage (%) of Recovered Drug in Urine</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot with Two Cohorts</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot with Six Cohorts</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpg01_cache/html/setup_9182d0db7d6ed474e3af1a52df0c8efd">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># loading in the data</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># filtering the rows for specific data entries</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"RCPCINT"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># adding or modifying specific columns</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">as.factor</span>(TRT01A)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(<span class="at">PARAM1 =</span> <span class="st">"Fe"</span>) <span class="sc">%&gt;%</span> <span class="co"># re-format PK parameter name</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">mutate</span>(<span class="at">Time =</span> <span class="fu">as.numeric</span>(<span class="fu">gsub</span>(<span class="st">"PT*|</span><span class="sc">\\</span><span class="st">.|H$"</span>, <span class="st">""</span>, PPENINT))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># in cases where the cohorts are numeric it is possible to rename them</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="fu">levels</span>(adpp<span class="sc">$</span>ARM) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="st">"A: Drug X"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="st">"C: Combination"</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkpg01_cache/html/plot1_940c9303ed2f6730bdd16a1476f67e8f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine </span><span class="sc">\n</span><span class="st">by Analyte, Visit: PK Evaluable Patients"</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X </span><span class="sc">\n</span><span class="st">Visit: CYCLE 1 DAY 1 </span><span class="sc">\n</span><span class="st">PK Parameter:"</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a></span>
+<span id="cb2-5"><a href="#cb2-5"></a>separation_between_barplots <span class="ot">&lt;-</span> <span class="fl">1.5</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a></span>
+<span id="cb2-7"><a href="#cb2-7"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="at">df =</span> adpp,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">x =</span> <span class="st">"Time"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM1"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ),</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">alt_counts_df =</span> adpp,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">y_lab =</span> <span class="st">"Cummulative Percentage"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">x_lab =</span> <span class="st">"Time (hours)"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>(),</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="at">position =</span> ggplot2<span class="sc">::</span><span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="dv">2</span>)</span>
+<span id="cb2-28"><a href="#cb2-28"></a>)</span>
+<span id="cb2-29"><a href="#cb2-29"></a></span>
+<span id="cb2-30"><a href="#cb2-30"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="dv">12</span>, <span class="dv">24</span>))</span>
+<span id="cb2-32"><a href="#cb2-32"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg01_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>In this case we need to process the data further by artificially adding more random rows. Of course this step is not necessary in the case that data already has more cohorts.</p>
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkpg01_cache/html/plot2_fb3d6b508dc8c504a32c4ea5fa3083b9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp_hck <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">mutate</span>(AVAL <span class="sc">+</span> <span class="dv">1</span> <span class="sc">*</span> <span class="fu">rnorm</span>(<span class="fu">nrow</span>(adpp), <span class="at">mean =</span> <span class="dv">1</span>, <span class="at">sd =</span> <span class="dv">1</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">as.factor</span>(<span class="fu">sample</span>(</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    <span class="fu">c</span>(</span>
+<span id="cb3-5"><a href="#cb3-5"></a>      <span class="st">"D: Drug D"</span>,</span>
+<span id="cb3-6"><a href="#cb3-6"></a>      <span class="st">"E: Drug E"</span>,</span>
+<span id="cb3-7"><a href="#cb3-7"></a>      <span class="st">"F: Drug F"</span>,</span>
+<span id="cb3-8"><a href="#cb3-8"></a>      <span class="st">"G: Drug G"</span></span>
+<span id="cb3-9"><a href="#cb3-9"></a>    ),</span>
+<span id="cb3-10"><a href="#cb3-10"></a>    <span class="fu">nrow</span>(adpp),</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="at">replace =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.4</span>, <span class="fl">0.3</span>, <span class="fl">0.2</span>, <span class="fl">0.1</span>)</span>
+<span id="cb3-13"><a href="#cb3-13"></a>  )))</span>
+<span id="cb3-14"><a href="#cb3-14"></a></span>
+<span id="cb3-15"><a href="#cb3-15"></a>adpp <span class="ot">&lt;-</span> <span class="fu">bind_rows</span>(adpp, adpp_hck)</span>
+<span id="cb3-16"><a href="#cb3-16"></a></span>
+<span id="cb3-17"><a href="#cb3-17"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine </span><span class="sc">\n</span><span class="st">by Analyte, Visit: PK Evaluable Patients"</span></span>
+<span id="cb3-18"><a href="#cb3-18"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X </span><span class="sc">\n</span><span class="st">Visit: CYCLE 1 DAY 1 </span><span class="sc">\n</span><span class="st">PK Parameter:"</span></span>
+<span id="cb3-19"><a href="#cb3-19"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb3-20"><a href="#cb3-20"></a></span>
+<span id="cb3-21"><a href="#cb3-21"></a>separation_between_barplots <span class="ot">&lt;-</span> <span class="fl">1.5</span></span>
+<span id="cb3-22"><a href="#cb3-22"></a></span>
+<span id="cb3-23"><a href="#cb3-23"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb3-24"><a href="#cb3-24"></a>  <span class="at">df =</span> adpp,</span>
+<span id="cb3-25"><a href="#cb3-25"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb3-26"><a href="#cb3-26"></a>    <span class="at">x =</span> <span class="st">"Time"</span>,</span>
+<span id="cb3-27"><a href="#cb3-27"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb3-28"><a href="#cb3-28"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb3-29"><a href="#cb3-29"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM1"</span>,</span>
+<span id="cb3-30"><a href="#cb3-30"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb3-31"><a href="#cb3-31"></a>  ),</span>
+<span id="cb3-32"><a href="#cb3-32"></a>  <span class="at">alt_counts_df =</span> adpp,</span>
+<span id="cb3-33"><a href="#cb3-33"></a>  <span class="at">y_lab =</span> <span class="st">"Cummulative Percentage"</span>,</span>
+<span id="cb3-34"><a href="#cb3-34"></a>  <span class="at">x_lab =</span> <span class="st">"Time (hours)"</span>,</span>
+<span id="cb3-35"><a href="#cb3-35"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb3-36"><a href="#cb3-36"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb3-37"><a href="#cb3-37"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb3-38"><a href="#cb3-38"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb3-39"><a href="#cb3-39"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb3-40"><a href="#cb3-40"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb3-41"><a href="#cb3-41"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb3-42"><a href="#cb3-42"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>(),</span>
+<span id="cb3-43"><a href="#cb3-43"></a>  <span class="at">position =</span> ggplot2<span class="sc">::</span><span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="dv">2</span>)</span>
+<span id="cb3-44"><a href="#cb3-44"></a>)</span>
+<span id="cb3-45"><a href="#cb3-45"></a></span>
+<span id="cb3-46"><a href="#cb3-46"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb3-47"><a href="#cb3-47"></a>  <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="dv">12</span>, <span class="dv">24</span>))</span>
+<span id="cb3-48"><a href="#cb3-48"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg01_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpg01_cache/html/teal_d8936fc54602499b03e272c2ea5f8aa2">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpg01_cache/html/sessioninfo_2b815c696032c630bee6b4be29619da4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   
+ [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    
+ [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       
+[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     
+[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      
+[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      
+[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 
+[29] forcats_1.0.0     broom_1.0.5       vctrs_0.6.3       R6_2.5.1         
+[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     
+[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     
+[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     
+[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  
+[49] compiler_4.3.1   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpg01_cache/html/snapshot_e50ea14434fa3baffc78a14315547a2f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkpg01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKPG01</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Plot of Mean Cumulative Percentage (%) of Recovered Drug in Urine</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb8-21"><a href="#cb8-21"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a></span>
+<span id="cb8-23"><a href="#cb8-23"></a><span class="co"># loading in the data</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a><span class="co"># filtering the rows for specific data entries</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"RCPCINT"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="co"># adding or modifying specific columns</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">as.factor</span>(TRT01A)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">mutate</span>(<span class="at">PARAM1 =</span> <span class="st">"Fe"</span>) <span class="sc">%&gt;%</span> <span class="co"># re-format PK parameter name</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="fu">mutate</span>(<span class="at">Time =</span> <span class="fu">as.numeric</span>(<span class="fu">gsub</span>(<span class="st">"PT*|</span><span class="sc">\\</span><span class="st">.|H$"</span>, <span class="st">""</span>, PPENINT))) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb8-37"><a href="#cb8-37"></a></span>
+<span id="cb8-38"><a href="#cb8-38"></a><span class="co"># in cases where the cohorts are numeric it is possible to rename them</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a><span class="fu">levels</span>(adpp<span class="sc">$</span>ARM) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="st">"A: Drug X"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="st">"C: Combination"</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>)</span>
+<span id="cb8-43"><a href="#cb8-43"></a><span class="in">```</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a></span>
+<span id="cb8-45"><a href="#cb8-45"></a><span class="fu">## Plot with Two Cohorts</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a></span>
+<span id="cb8-47"><a href="#cb8-47"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine </span><span class="sc">\n</span><span class="st">by Analyte, Visit: PK Evaluable Patients"</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X </span><span class="sc">\n</span><span class="st">Visit: CYCLE 1 DAY 1 </span><span class="sc">\n</span><span class="st">PK Parameter:"</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a></span>
+<span id="cb8-52"><a href="#cb8-52"></a>separation_between_barplots <span class="ot">&lt;-</span> <span class="fl">1.5</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a></span>
+<span id="cb8-54"><a href="#cb8-54"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>  <span class="at">df =</span> adpp,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">x =</span> <span class="st">"Time"</span>,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM1"</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  ),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>  <span class="at">alt_counts_df =</span> adpp,</span>
+<span id="cb8-64"><a href="#cb8-64"></a>  <span class="at">y_lab =</span> <span class="st">"Cummulative Percentage"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="at">x_lab =</span> <span class="st">"Time (hours)"</span>,</span>
+<span id="cb8-66"><a href="#cb8-66"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-67"><a href="#cb8-67"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-68"><a href="#cb8-68"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb8-69"><a href="#cb8-69"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>(),</span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="at">position =</span> ggplot2<span class="sc">::</span><span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="dv">2</span>)</span>
+<span id="cb8-75"><a href="#cb8-75"></a>)</span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a>  <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="dv">12</span>, <span class="dv">24</span>))</span>
+<span id="cb8-79"><a href="#cb8-79"></a>plot</span>
+<span id="cb8-80"><a href="#cb8-80"></a><span class="in">```</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a></span>
+<span id="cb8-82"><a href="#cb8-82"></a><span class="fu">## Plot with Six Cohorts</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a>In this case we need to process the data further by artificially adding more random rows.</span>
+<span id="cb8-85"><a href="#cb8-85"></a>Of course this step is not necessary in the case that data already has more cohorts.</span>
+<span id="cb8-86"><a href="#cb8-86"></a></span>
+<span id="cb8-87"><a href="#cb8-87"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb8-88"><a href="#cb8-88"></a>adpp_hck <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>  <span class="fu">mutate</span>(AVAL <span class="sc">+</span> <span class="dv">1</span> <span class="sc">*</span> <span class="fu">rnorm</span>(<span class="fu">nrow</span>(adpp), <span class="at">mean =</span> <span class="dv">1</span>, <span class="at">sd =</span> <span class="dv">1</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-90"><a href="#cb8-90"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">as.factor</span>(<span class="fu">sample</span>(</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    <span class="fu">c</span>(</span>
+<span id="cb8-92"><a href="#cb8-92"></a>      <span class="st">"D: Drug D"</span>,</span>
+<span id="cb8-93"><a href="#cb8-93"></a>      <span class="st">"E: Drug E"</span>,</span>
+<span id="cb8-94"><a href="#cb8-94"></a>      <span class="st">"F: Drug F"</span>,</span>
+<span id="cb8-95"><a href="#cb8-95"></a>      <span class="st">"G: Drug G"</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a>    ),</span>
+<span id="cb8-97"><a href="#cb8-97"></a>    <span class="fu">nrow</span>(adpp),</span>
+<span id="cb8-98"><a href="#cb8-98"></a>    <span class="at">replace =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.4</span>, <span class="fl">0.3</span>, <span class="fl">0.2</span>, <span class="fl">0.1</span>)</span>
+<span id="cb8-100"><a href="#cb8-100"></a>  )))</span>
+<span id="cb8-101"><a href="#cb8-101"></a></span>
+<span id="cb8-102"><a href="#cb8-102"></a>adpp <span class="ot">&lt;-</span> <span class="fu">bind_rows</span>(adpp, adpp_hck)</span>
+<span id="cb8-103"><a href="#cb8-103"></a></span>
+<span id="cb8-104"><a href="#cb8-104"></a>use_title <span class="ot">&lt;-</span> <span class="st">"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine </span><span class="sc">\n</span><span class="st">by Analyte, Visit: PK Evaluable Patients"</span></span>
+<span id="cb8-105"><a href="#cb8-105"></a>use_subtitle <span class="ot">&lt;-</span> <span class="st">"Analyte: Plasma Drug X </span><span class="sc">\n</span><span class="st">Visit: CYCLE 1 DAY 1 </span><span class="sc">\n</span><span class="st">PK Parameter:"</span></span>
+<span id="cb8-106"><a href="#cb8-106"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb8-107"><a href="#cb8-107"></a></span>
+<span id="cb8-108"><a href="#cb8-108"></a>separation_between_barplots <span class="ot">&lt;-</span> <span class="fl">1.5</span></span>
+<span id="cb8-109"><a href="#cb8-109"></a></span>
+<span id="cb8-110"><a href="#cb8-110"></a>result <span class="ot">&lt;-</span> <span class="fu">g_lineplot</span>(</span>
+<span id="cb8-111"><a href="#cb8-111"></a>  <span class="at">df =</span> adpp,</span>
+<span id="cb8-112"><a href="#cb8-112"></a>  <span class="at">variables =</span> <span class="fu">control_lineplot_vars</span>(</span>
+<span id="cb8-113"><a href="#cb8-113"></a>    <span class="at">x =</span> <span class="st">"Time"</span>,</span>
+<span id="cb8-114"><a href="#cb8-114"></a>    <span class="at">y =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-115"><a href="#cb8-115"></a>    <span class="at">strata =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb8-116"><a href="#cb8-116"></a>    <span class="at">paramcd =</span> <span class="st">"PARAM1"</span>,</span>
+<span id="cb8-117"><a href="#cb8-117"></a>    <span class="at">y_unit =</span> <span class="st">"AVALU"</span></span>
+<span id="cb8-118"><a href="#cb8-118"></a>  ),</span>
+<span id="cb8-119"><a href="#cb8-119"></a>  <span class="at">alt_counts_df =</span> adpp,</span>
+<span id="cb8-120"><a href="#cb8-120"></a>  <span class="at">y_lab =</span> <span class="st">"Cummulative Percentage"</span>,</span>
+<span id="cb8-121"><a href="#cb8-121"></a>  <span class="at">x_lab =</span> <span class="st">"Time (hours)"</span>,</span>
+<span id="cb8-122"><a href="#cb8-122"></a>  <span class="at">y_lab_add_paramcd =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-123"><a href="#cb8-123"></a>  <span class="at">y_lab_add_unit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-124"><a href="#cb8-124"></a>  <span class="at">interval =</span> <span class="st">"mean_sdi"</span>,</span>
+<span id="cb8-125"><a href="#cb8-125"></a>  <span class="at">whiskers =</span> <span class="fu">c</span>(<span class="st">"mean_sdi_lwr"</span>, <span class="st">"mean_sdi_upr"</span>),</span>
+<span id="cb8-126"><a href="#cb8-126"></a>  <span class="at">title =</span> use_title,</span>
+<span id="cb8-127"><a href="#cb8-127"></a>  <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb8-128"><a href="#cb8-128"></a>  <span class="at">caption =</span> use_footnote,</span>
+<span id="cb8-129"><a href="#cb8-129"></a>  <span class="at">ggtheme =</span> <span class="fu">theme_nest</span>(),</span>
+<span id="cb8-130"><a href="#cb8-130"></a>  <span class="at">position =</span> ggplot2<span class="sc">::</span><span class="fu">position_dodge</span>(<span class="at">width =</span> <span class="dv">2</span>)</span>
+<span id="cb8-131"><a href="#cb8-131"></a>)</span>
+<span id="cb8-132"><a href="#cb8-132"></a></span>
+<span id="cb8-133"><a href="#cb8-133"></a>plot <span class="ot">&lt;-</span> result <span class="sc">+</span> <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb8-134"><a href="#cb8-134"></a>  <span class="fu">scale_x_continuous</span>(<span class="at">breaks =</span> <span class="fu">c</span>(<span class="dv">12</span>, <span class="dv">24</span>))</span>
+<span id="cb8-135"><a href="#cb8-135"></a>plot</span>
+<span id="cb8-136"><a href="#cb8-136"></a><span class="in">```</span></span>
+<span id="cb8-137"><a href="#cb8-137"></a></span>
+<span id="cb8-138"><a href="#cb8-138"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-139"><a href="#cb8-139"></a></span>
+<span id="cb8-140"><a href="#cb8-140"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-141"><a href="#cb8-141"></a></span>
+<span id="cb8-142"><a href="#cb8-142"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-143"><a href="#cb8-143"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-144"><a href="#cb8-144"></a></span>
+<span id="cb8-145"><a href="#cb8-145"></a><span class="co"># In progress</span></span>
+<span id="cb8-146"><a href="#cb8-146"></a><span class="in">```</span></span>
+<span id="cb8-147"><a href="#cb8-147"></a></span>
+<span id="cb8-148"><a href="#cb8-148"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-149"><a href="#cb8-149"></a></span>
+<span id="cb8-150"><a href="#cb8-150"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/graphs/pharmacokinetic/pkpg01_files/figure-html/plot1-1.png b/stable/graphs/pharmacokinetic/pkpg01_files/figure-html/plot1-1.png
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diff --git a/stable/graphs/pharmacokinetic/pkpg02.html b/stable/graphs/pharmacokinetic/pkpg02.html
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<div class="quarto-title-block"><div><h1 class="title">PKPG02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary of Serum PK Parameters by Treatment</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Summary of Pharmacokinetic <br> Parameters – Plasma</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Summary of Plasma Pharmacokinetic <br> Parameters with Median Points</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpg02_cache/html/setup_b7711452a23c1f5c6e7aaceca9cbfcdb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># need adex for dose info and adpp for AUC max info</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adpp_a <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    AVISITN <span class="sc">==</span> <span class="st">"1"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">==</span> <span class="st">"AUCIFO"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(<span class="at">AUCinf =</span> AVAL)</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>adex_a <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    AVISITN <span class="sc">==</span> <span class="st">"1"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DOSE"</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">mutate</span>(<span class="at">Dose =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">select</span>(USUBJID, Dose)</span>
+<span id="cb1-26"><a href="#cb1-26"></a></span>
+<span id="cb1-27"><a href="#cb1-27"></a><span class="co"># join the dose information to the adpp table</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>adpp_adex <span class="ot">&lt;-</span> <span class="fu">left_join</span>(adpp_a, adex_a, <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">group_by</span>(<span class="st">`</span><span class="at">ARM</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(<span class="at">count =</span> <span class="fu">paste0</span>(<span class="st">`</span><span class="at">ARM</span><span class="st">`</span>, <span class="st">" ("</span>, <span class="fu">n</span>(), <span class="st">")"</span>))</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a><span class="co"># set x and y variable names</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>x_var <span class="ot">&lt;-</span> <span class="st">"Dose"</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>y_var <span class="ot">&lt;-</span> <span class="st">"AUCinf"</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkpg02_cache/html/plot1_7cb1e83e0ee7b16ee3dc10c2e349bfd6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># calculate Summary Statistics (mean and sd) for each group</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>SummaryStat <span class="ot">&lt;-</span> adpp_adex <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">group_by</span>(<span class="at">Dose =</span> <span class="fu">as.factor</span>(Dose)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">summarise</span>(<span class="at">AUCsd =</span> <span class="fu">sd</span>(AUCinf), <span class="at">meanAUC =</span> <span class="fu">mean</span>(AUCinf))</span>
+<span id="cb2-5"><a href="#cb2-5"></a>SummaryStat<span class="sc">$</span>Dose <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">as.character</span>(SummaryStat<span class="sc">$</span>Dose))</span>
+<span id="cb2-6"><a href="#cb2-6"></a></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="co"># generate linear model</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>mod1 <span class="ot">&lt;-</span> <span class="fu">lm</span>(<span class="fu">log</span>(AUCinf) <span class="sc">~</span> <span class="fu">log</span>(Dose), adpp_adex)</span>
+<span id="cb2-9"><a href="#cb2-9"></a></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="co"># obtain linear model coefficient values</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>cf <span class="ot">&lt;-</span> <span class="fu">round</span>(<span class="fu">coef</span>(mod1), <span class="dv">2</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a><span class="co"># generate linear model equation</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>eq <span class="ot">&lt;-</span> <span class="fu">paste0</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="st">"y = "</span>, cf[<span class="dv">1</span>],</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">ifelse</span>(<span class="fu">sign</span>(cf[<span class="dv">2</span>]) <span class="sc">==</span> <span class="dv">1</span>, <span class="st">" + "</span>, <span class="st">" - "</span>), <span class="fu">abs</span>(cf[<span class="dv">2</span>]), <span class="st">" x , "</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="st">"R²"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="st">" = "</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">signif</span>(<span class="fu">summary</span>(mod1)<span class="sc">$</span>adj.r.squared, <span class="dv">3</span>)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>)</span>
+<span id="cb2-21"><a href="#cb2-21"></a></span>
+<span id="cb2-22"><a href="#cb2-22"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp_adex, <span class="fu">aes</span>(<span class="at">x =</span> .data[[x_var]], <span class="at">y =</span> .data[[y_var]])) <span class="sc">+</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">annotate</span>(<span class="at">geom =</span> <span class="st">"text"</span>, <span class="at">x =</span> <span class="fu">min</span>(adpp_adex[[x_var]]), <span class="at">y =</span> <span class="fu">max</span>(adpp_adex[[y_var]]), <span class="at">label =</span> eq, <span class="at">hjust =</span> <span class="fl">0.1</span>) <span class="sc">+</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">geom_point</span>(<span class="at">size =</span> <span class="dv">1</span>, <span class="fu">aes</span>(<span class="at">color =</span> <span class="fu">factor</span>(<span class="st">`</span><span class="at">count</span><span class="st">`</span>))) <span class="sc">+</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">scale_x_continuous</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">name =</span> <span class="st">"Dose (mg/mL)"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">breaks =</span> <span class="fu">unique</span>(adpp_adex<span class="sc">$</span>Dose)</span>
+<span id="cb2-28"><a href="#cb2-28"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  <span class="fu">scale_y_continuous</span>(</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">name =</span> <span class="fu">paste</span>(y_var, adpp_a<span class="sc">$</span>AVALU),</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">trans =</span> <span class="st">"log"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">breaks =</span> <span class="fu">exp</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(</span>
+<span id="cb2-33"><a href="#cb2-33"></a>      <span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)),</span>
+<span id="cb2-34"><a href="#cb2-34"></a>      <span class="at">by =</span> <span class="dv">1</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>    ))),</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">labels =</span> <span class="fu">as.character</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(</span>
+<span id="cb2-37"><a href="#cb2-37"></a>      <span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)),</span>
+<span id="cb2-38"><a href="#cb2-38"></a>      <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>    )))</span>
+<span id="cb2-40"><a href="#cb2-40"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="fu">geom_smooth</span>(<span class="at">method =</span> <span class="st">"lm"</span>, <span class="at">formula =</span> y <span class="sc">~</span> x, <span class="at">se =</span> F, <span class="at">color =</span> <span class="st">"black"</span>, <span class="at">linewidth =</span> <span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="co"># Display error bars for each dosing group (this will only appear if the sd is less than the mean)</span></span>
+<span id="cb2-43"><a href="#cb2-43"></a>  <span class="fu">geom_errorbar</span>(</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> <span class="st">`</span><span class="at">Dose</span><span class="st">`</span>, <span class="at">y =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span>, <span class="at">ymin =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span> <span class="sc">-</span> <span class="st">`</span><span class="at">AUCsd</span><span class="st">`</span>, <span class="at">ymax =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span> <span class="sc">+</span> AUCsd), <span class="at">width =</span> .<span class="dv">05</span>,</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(.<span class="dv">1</span>)</span>
+<span id="cb2-46"><a href="#cb2-46"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> Dose, <span class="at">y =</span> meanAUC, <span class="at">size =</span> <span class="dv">1</span>), <span class="at">shape =</span> <span class="dv">2</span>, <span class="at">show.legend =</span> <span class="cn">FALSE</span>) <span class="sc">+</span></span>
+<span id="cb2-48"><a href="#cb2-48"></a>  <span class="fu">ggtitle</span>(<span class="fu">paste</span>(</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="st">"Dose-Proportionality Plot of Serum"</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adex<span class="sc">$</span>TRT01P)),</span>
+<span id="cb2-50"><a href="#cb2-50"></a>    y_var, <span class="st">"in"</span>, adpp_a<span class="sc">$</span>AVALU</span>
+<span id="cb2-51"><a href="#cb2-51"></a>  ), <span class="at">subtitle =</span> <span class="st">"Summary of serum PK parameters by treatment"</span>) <span class="sc">+</span></span>
+<span id="cb2-52"><a href="#cb2-52"></a>  <span class="fu">labs</span>(<span class="at">color =</span> <span class="st">"Treatment Arm"</span>) <span class="sc">+</span></span>
+<span id="cb2-53"><a href="#cb2-53"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb2-54"><a href="#cb2-54"></a></span>
+<span id="cb2-55"><a href="#cb2-55"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg02_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkpg02_cache/html/plot2_3dc7560aa629cbf200994de67fdde281">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a><span class="co"># calculate median for each group if preferred</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>SummaryStat <span class="ot">&lt;-</span> adpp_adex <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">group_by</span>(<span class="at">Dose =</span> <span class="fu">as.factor</span>(Dose)) <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">summarise</span>(<span class="at">medAUC =</span> <span class="fu">median</span>(AUCinf))</span>
+<span id="cb3-5"><a href="#cb3-5"></a>SummaryStat<span class="sc">$</span>Dose <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">as.character</span>(SummaryStat<span class="sc">$</span>Dose))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp_adex, <span class="fu">aes</span>(<span class="at">x =</span> .data[[x_var]], <span class="at">y =</span> .data[[y_var]])) <span class="sc">+</span></span>
+<span id="cb3-8"><a href="#cb3-8"></a>  <span class="fu">annotate</span>(<span class="at">geom =</span> <span class="st">"text"</span>, <span class="at">x =</span> <span class="fu">min</span>(adpp_adex[[x_var]]), <span class="at">y =</span> <span class="fu">max</span>(adpp_adex[[y_var]]), <span class="at">label =</span> eq, <span class="at">hjust =</span> <span class="fl">0.1</span>) <span class="sc">+</span></span>
+<span id="cb3-9"><a href="#cb3-9"></a>  <span class="fu">geom_point</span>(<span class="at">size =</span> <span class="dv">1</span>, <span class="fu">aes</span>(<span class="at">color =</span> <span class="fu">factor</span>(<span class="st">`</span><span class="at">count</span><span class="st">`</span>))) <span class="sc">+</span></span>
+<span id="cb3-10"><a href="#cb3-10"></a>  <span class="fu">geom_smooth</span>(<span class="at">method =</span> <span class="st">"lm"</span>, <span class="at">formula =</span> y <span class="sc">~</span> x, <span class="at">se =</span> F, <span class="at">color =</span> <span class="st">"black"</span>, <span class="at">linewidth =</span> <span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb3-11"><a href="#cb3-11"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> Dose, <span class="at">y =</span> medAUC, <span class="at">size =</span> <span class="dv">1</span>), <span class="at">shape =</span> <span class="dv">2</span>, <span class="at">show.legend =</span> <span class="cn">FALSE</span>) <span class="sc">+</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a>  <span class="fu">ggtitle</span>(<span class="fu">paste</span>(<span class="st">"Dose-Proportionality Plot of Serum"</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adex<span class="sc">$</span>TRT01P)), y_var, <span class="st">"in"</span>, adpp_a<span class="sc">$</span>AVALU), <span class="at">subtitle =</span> <span class="st">"Summary of serum PK parameters by treatment"</span>) <span class="sc">+</span></span>
+<span id="cb3-13"><a href="#cb3-13"></a>  <span class="fu">labs</span>(<span class="at">color =</span> <span class="st">"Treatment Arm"</span>) <span class="sc">+</span></span>
+<span id="cb3-14"><a href="#cb3-14"></a>  <span class="fu">scale_y_continuous</span>(</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">name =</span> <span class="fu">paste</span>(y_var, adpp_a<span class="sc">$</span>AVALU),</span>
+<span id="cb3-16"><a href="#cb3-16"></a>    <span class="at">trans =</span> <span class="st">"log"</span>,</span>
+<span id="cb3-17"><a href="#cb3-17"></a>    <span class="at">breaks =</span> <span class="fu">exp</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(<span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span>))),</span>
+<span id="cb3-18"><a href="#cb3-18"></a>    <span class="at">labels =</span> <span class="fu">as.character</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(<span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span>)))</span>
+<span id="cb3-19"><a href="#cb3-19"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-20"><a href="#cb3-20"></a>  <span class="fu">scale_x_continuous</span>(</span>
+<span id="cb3-21"><a href="#cb3-21"></a>    <span class="at">name =</span> <span class="st">"Dose (mg/mL)"</span>,</span>
+<span id="cb3-22"><a href="#cb3-22"></a>    <span class="at">breaks =</span> <span class="fu">unique</span>(adpp_adex<span class="sc">$</span>Dose)</span>
+<span id="cb3-23"><a href="#cb3-23"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-24"><a href="#cb3-24"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb3-25"><a href="#cb3-25"></a></span>
+<span id="cb3-26"><a href="#cb3-26"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg02_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpg02_cache/html/teal_0bf94be615733b2dd01c661991967852">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpg02_cache/html/sessioninfo_3c0017c1243c48255c8d4a3a621b4117">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   
+ [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    
+ [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       
+[13] survival_3.5-7    mgcv_1.9-0        purrr_1.0.2       fansi_1.0.4      
+[17] scales_1.2.1      codetools_0.2-19  Rdpack_2.5        cli_3.6.1        
+[21] rlang_1.1.1       rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1    
+[25] withr_2.5.0       yaml_2.3.7        tools_4.3.1       checkmate_2.2.0  
+[29] colorspace_2.1-0  broom_1.0.5       vctrs_0.6.3       R6_2.5.1         
+[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     
+[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     
+[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     
+[45] htmltools_0.5.6   nlme_3.1-163      rmarkdown_2.25    testthat_3.1.10  
+[49] compiler_4.3.1   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpg02_cache/html/snapshot_349e2237032953ab54b4fc0cc19a14ff">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkpg02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKPG02</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary of Serum PK Parameters by Treatment</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a><span class="co"># need adex for dose info and adpp for AUC max info</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a>adpp_a <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    AVISITN <span class="sc">==</span> <span class="st">"1"</span>,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    PARAMCD <span class="sc">==</span> <span class="st">"AUCIFO"</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="fu">mutate</span>(<span class="at">AUCinf =</span> AVAL)</span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a>adex_a <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    AVISITN <span class="sc">==</span> <span class="st">"1"</span>,</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DOSE"</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  <span class="fu">mutate</span>(<span class="at">Dose =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="fu">select</span>(USUBJID, Dose)</span>
+<span id="cb8-41"><a href="#cb8-41"></a></span>
+<span id="cb8-42"><a href="#cb8-42"></a><span class="co"># join the dose information to the adpp table</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>adpp_adex <span class="ot">&lt;-</span> <span class="fu">left_join</span>(adpp_a, adex_a, <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="fu">group_by</span>(<span class="st">`</span><span class="at">ARM</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="fu">mutate</span>(<span class="at">count =</span> <span class="fu">paste0</span>(<span class="st">`</span><span class="at">ARM</span><span class="st">`</span>, <span class="st">" ("</span>, <span class="fu">n</span>(), <span class="st">")"</span>))</span>
+<span id="cb8-46"><a href="#cb8-46"></a></span>
+<span id="cb8-47"><a href="#cb8-47"></a><span class="co"># set x and y variable names</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>x_var <span class="ot">&lt;-</span> <span class="st">"Dose"</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>y_var <span class="ot">&lt;-</span> <span class="st">"AUCinf"</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a><span class="in">```</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a></span>
+<span id="cb8-52"><a href="#cb8-52"></a><span class="fu">## Summary of Pharmacokinetic &lt;br/&gt; Parameters -- Plasma</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a></span>
+<span id="cb8-54"><a href="#cb8-54"></a><span class="in">```{r plot1, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="co"># calculate Summary Statistics (mean and sd) for each group</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>SummaryStat <span class="ot">&lt;-</span> adpp_adex <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">group_by</span>(<span class="at">Dose =</span> <span class="fu">as.factor</span>(Dose)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  <span class="fu">summarise</span>(<span class="at">AUCsd =</span> <span class="fu">sd</span>(AUCinf), <span class="at">meanAUC =</span> <span class="fu">mean</span>(AUCinf))</span>
+<span id="cb8-59"><a href="#cb8-59"></a>SummaryStat<span class="sc">$</span>Dose <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">as.character</span>(SummaryStat<span class="sc">$</span>Dose))</span>
+<span id="cb8-60"><a href="#cb8-60"></a></span>
+<span id="cb8-61"><a href="#cb8-61"></a><span class="co"># generate linear model</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>mod1 <span class="ot">&lt;-</span> <span class="fu">lm</span>(<span class="fu">log</span>(AUCinf) <span class="sc">~</span> <span class="fu">log</span>(Dose), adpp_adex)</span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a><span class="co"># obtain linear model coefficient values</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>cf <span class="ot">&lt;-</span> <span class="fu">round</span>(<span class="fu">coef</span>(mod1), <span class="dv">2</span>)</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a><span class="co"># generate linear model equation</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>eq <span class="ot">&lt;-</span> <span class="fu">paste0</span>(</span>
+<span id="cb8-69"><a href="#cb8-69"></a>  <span class="st">"y = "</span>, cf[<span class="dv">1</span>],</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  <span class="fu">ifelse</span>(<span class="fu">sign</span>(cf[<span class="dv">2</span>]) <span class="sc">==</span> <span class="dv">1</span>, <span class="st">" + "</span>, <span class="st">" - "</span>), <span class="fu">abs</span>(cf[<span class="dv">2</span>]), <span class="st">" x , "</span>,</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="st">"R²"</span>,</span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="st">" = "</span>,</span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">signif</span>(<span class="fu">summary</span>(mod1)<span class="sc">$</span>adj.r.squared, <span class="dv">3</span>)</span>
+<span id="cb8-74"><a href="#cb8-74"></a>)</span>
+<span id="cb8-75"><a href="#cb8-75"></a></span>
+<span id="cb8-76"><a href="#cb8-76"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp_adex, <span class="fu">aes</span>(<span class="at">x =</span> .data[[x_var]], <span class="at">y =</span> .data[[y_var]])) <span class="sc">+</span></span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="fu">annotate</span>(<span class="at">geom =</span> <span class="st">"text"</span>, <span class="at">x =</span> <span class="fu">min</span>(adpp_adex[[x_var]]), <span class="at">y =</span> <span class="fu">max</span>(adpp_adex[[y_var]]), <span class="at">label =</span> eq, <span class="at">hjust =</span> <span class="fl">0.1</span>) <span class="sc">+</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a>  <span class="fu">geom_point</span>(<span class="at">size =</span> <span class="dv">1</span>, <span class="fu">aes</span>(<span class="at">color =</span> <span class="fu">factor</span>(<span class="st">`</span><span class="at">count</span><span class="st">`</span>))) <span class="sc">+</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="fu">scale_x_continuous</span>(</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="at">name =</span> <span class="st">"Dose (mg/mL)"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    <span class="at">breaks =</span> <span class="fu">unique</span>(adpp_adex<span class="sc">$</span>Dose)</span>
+<span id="cb8-82"><a href="#cb8-82"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a>  <span class="fu">scale_y_continuous</span>(</span>
+<span id="cb8-84"><a href="#cb8-84"></a>    <span class="at">name =</span> <span class="fu">paste</span>(y_var, adpp_a<span class="sc">$</span>AVALU),</span>
+<span id="cb8-85"><a href="#cb8-85"></a>    <span class="at">trans =</span> <span class="st">"log"</span>,</span>
+<span id="cb8-86"><a href="#cb8-86"></a>    <span class="at">breaks =</span> <span class="fu">exp</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(</span>
+<span id="cb8-87"><a href="#cb8-87"></a>      <span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)),</span>
+<span id="cb8-88"><a href="#cb8-88"></a>      <span class="at">by =</span> <span class="dv">1</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>    ))),</span>
+<span id="cb8-90"><a href="#cb8-90"></a>    <span class="at">labels =</span> <span class="fu">as.character</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(</span>
+<span id="cb8-91"><a href="#cb8-91"></a>      <span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)),</span>
+<span id="cb8-92"><a href="#cb8-92"></a>      <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span></span>
+<span id="cb8-93"><a href="#cb8-93"></a>    )))</span>
+<span id="cb8-94"><a href="#cb8-94"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-95"><a href="#cb8-95"></a>  <span class="fu">geom_smooth</span>(<span class="at">method =</span> <span class="st">"lm"</span>, <span class="at">formula =</span> y <span class="sc">~</span> x, <span class="at">se =</span> F, <span class="at">color =</span> <span class="st">"black"</span>, <span class="at">linewidth =</span> <span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a>  <span class="co"># Display error bars for each dosing group (this will only appear if the sd is less than the mean)</span></span>
+<span id="cb8-97"><a href="#cb8-97"></a>  <span class="fu">geom_errorbar</span>(</span>
+<span id="cb8-98"><a href="#cb8-98"></a>    <span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> <span class="st">`</span><span class="at">Dose</span><span class="st">`</span>, <span class="at">y =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span>, <span class="at">ymin =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span> <span class="sc">-</span> <span class="st">`</span><span class="at">AUCsd</span><span class="st">`</span>, <span class="at">ymax =</span> <span class="st">`</span><span class="at">meanAUC</span><span class="st">`</span> <span class="sc">+</span> AUCsd), <span class="at">width =</span> .<span class="dv">05</span>,</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(.<span class="dv">1</span>)</span>
+<span id="cb8-100"><a href="#cb8-100"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-101"><a href="#cb8-101"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> Dose, <span class="at">y =</span> meanAUC, <span class="at">size =</span> <span class="dv">1</span>), <span class="at">shape =</span> <span class="dv">2</span>, <span class="at">show.legend =</span> <span class="cn">FALSE</span>) <span class="sc">+</span></span>
+<span id="cb8-102"><a href="#cb8-102"></a>  <span class="fu">ggtitle</span>(<span class="fu">paste</span>(</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="st">"Dose-Proportionality Plot of Serum"</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adex<span class="sc">$</span>TRT01P)),</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    y_var, <span class="st">"in"</span>, adpp_a<span class="sc">$</span>AVALU</span>
+<span id="cb8-105"><a href="#cb8-105"></a>  ), <span class="at">subtitle =</span> <span class="st">"Summary of serum PK parameters by treatment"</span>) <span class="sc">+</span></span>
+<span id="cb8-106"><a href="#cb8-106"></a>  <span class="fu">labs</span>(<span class="at">color =</span> <span class="st">"Treatment Arm"</span>) <span class="sc">+</span></span>
+<span id="cb8-107"><a href="#cb8-107"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb8-108"><a href="#cb8-108"></a></span>
+<span id="cb8-109"><a href="#cb8-109"></a>plot</span>
+<span id="cb8-110"><a href="#cb8-110"></a><span class="in">```</span></span>
+<span id="cb8-111"><a href="#cb8-111"></a></span>
+<span id="cb8-112"><a href="#cb8-112"></a><span class="fu">## Summary of Plasma Pharmacokinetic &lt;br/&gt; Parameters with Median Points</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a></span>
+<span id="cb8-114"><a href="#cb8-114"></a><span class="in">```{r plot2, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb8-115"><a href="#cb8-115"></a><span class="co"># calculate median for each group if preferred</span></span>
+<span id="cb8-116"><a href="#cb8-116"></a>SummaryStat <span class="ot">&lt;-</span> adpp_adex <span class="sc">%&gt;%</span></span>
+<span id="cb8-117"><a href="#cb8-117"></a>  <span class="fu">group_by</span>(<span class="at">Dose =</span> <span class="fu">as.factor</span>(Dose)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-118"><a href="#cb8-118"></a>  <span class="fu">summarise</span>(<span class="at">medAUC =</span> <span class="fu">median</span>(AUCinf))</span>
+<span id="cb8-119"><a href="#cb8-119"></a>SummaryStat<span class="sc">$</span>Dose <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">as.character</span>(SummaryStat<span class="sc">$</span>Dose))</span>
+<span id="cb8-120"><a href="#cb8-120"></a></span>
+<span id="cb8-121"><a href="#cb8-121"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp_adex, <span class="fu">aes</span>(<span class="at">x =</span> .data[[x_var]], <span class="at">y =</span> .data[[y_var]])) <span class="sc">+</span></span>
+<span id="cb8-122"><a href="#cb8-122"></a>  <span class="fu">annotate</span>(<span class="at">geom =</span> <span class="st">"text"</span>, <span class="at">x =</span> <span class="fu">min</span>(adpp_adex[[x_var]]), <span class="at">y =</span> <span class="fu">max</span>(adpp_adex[[y_var]]), <span class="at">label =</span> eq, <span class="at">hjust =</span> <span class="fl">0.1</span>) <span class="sc">+</span></span>
+<span id="cb8-123"><a href="#cb8-123"></a>  <span class="fu">geom_point</span>(<span class="at">size =</span> <span class="dv">1</span>, <span class="fu">aes</span>(<span class="at">color =</span> <span class="fu">factor</span>(<span class="st">`</span><span class="at">count</span><span class="st">`</span>))) <span class="sc">+</span></span>
+<span id="cb8-124"><a href="#cb8-124"></a>  <span class="fu">geom_smooth</span>(<span class="at">method =</span> <span class="st">"lm"</span>, <span class="at">formula =</span> y <span class="sc">~</span> x, <span class="at">se =</span> F, <span class="at">color =</span> <span class="st">"black"</span>, <span class="at">linewidth =</span> <span class="fl">0.5</span>) <span class="sc">+</span></span>
+<span id="cb8-125"><a href="#cb8-125"></a>  <span class="fu">geom_point</span>(<span class="at">data =</span> SummaryStat, <span class="fu">aes</span>(<span class="at">x =</span> Dose, <span class="at">y =</span> medAUC, <span class="at">size =</span> <span class="dv">1</span>), <span class="at">shape =</span> <span class="dv">2</span>, <span class="at">show.legend =</span> <span class="cn">FALSE</span>) <span class="sc">+</span></span>
+<span id="cb8-126"><a href="#cb8-126"></a>  <span class="fu">ggtitle</span>(<span class="fu">paste</span>(<span class="st">"Dose-Proportionality Plot of Serum"</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adex<span class="sc">$</span>TRT01P)), y_var, <span class="st">"in"</span>, adpp_a<span class="sc">$</span>AVALU), <span class="at">subtitle =</span> <span class="st">"Summary of serum PK parameters by treatment"</span>) <span class="sc">+</span></span>
+<span id="cb8-127"><a href="#cb8-127"></a>  <span class="fu">labs</span>(<span class="at">color =</span> <span class="st">"Treatment Arm"</span>) <span class="sc">+</span></span>
+<span id="cb8-128"><a href="#cb8-128"></a>  <span class="fu">scale_y_continuous</span>(</span>
+<span id="cb8-129"><a href="#cb8-129"></a>    <span class="at">name =</span> <span class="fu">paste</span>(y_var, adpp_a<span class="sc">$</span>AVALU),</span>
+<span id="cb8-130"><a href="#cb8-130"></a>    <span class="at">trans =</span> <span class="st">"log"</span>,</span>
+<span id="cb8-131"><a href="#cb8-131"></a>    <span class="at">breaks =</span> <span class="fu">exp</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(<span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span>))),</span>
+<span id="cb8-132"><a href="#cb8-132"></a>    <span class="at">labels =</span> <span class="fu">as.character</span>(<span class="fu">ceiling</span>(<span class="fu">seq</span>(<span class="at">from =</span> <span class="fu">min</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">to =</span> <span class="fu">max</span>(<span class="fu">log</span>(adpp_adex<span class="sc">$</span>AUCinf)), <span class="at">by =</span> <span class="dv">1</span>)))</span>
+<span id="cb8-133"><a href="#cb8-133"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-134"><a href="#cb8-134"></a>  <span class="fu">scale_x_continuous</span>(</span>
+<span id="cb8-135"><a href="#cb8-135"></a>    <span class="at">name =</span> <span class="st">"Dose (mg/mL)"</span>,</span>
+<span id="cb8-136"><a href="#cb8-136"></a>    <span class="at">breaks =</span> <span class="fu">unique</span>(adpp_adex<span class="sc">$</span>Dose)</span>
+<span id="cb8-137"><a href="#cb8-137"></a>  ) <span class="sc">+</span></span>
+<span id="cb8-138"><a href="#cb8-138"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb8-139"><a href="#cb8-139"></a></span>
+<span id="cb8-140"><a href="#cb8-140"></a>plot</span>
+<span id="cb8-141"><a href="#cb8-141"></a><span class="in">```</span></span>
+<span id="cb8-142"><a href="#cb8-142"></a></span>
+<span id="cb8-143"><a href="#cb8-143"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-144"><a href="#cb8-144"></a></span>
+<span id="cb8-145"><a href="#cb8-145"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-146"><a href="#cb8-146"></a></span>
+<span id="cb8-147"><a href="#cb8-147"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-148"><a href="#cb8-148"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-149"><a href="#cb8-149"></a></span>
+<span id="cb8-150"><a href="#cb8-150"></a><span class="co"># In progress</span></span>
+<span id="cb8-151"><a href="#cb8-151"></a><span class="in">```</span></span>
+<span id="cb8-152"><a href="#cb8-152"></a></span>
+<span id="cb8-153"><a href="#cb8-153"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-154"><a href="#cb8-154"></a></span>
+<span id="cb8-155"><a href="#cb8-155"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
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+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPG03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Box Plot of Pharmacokinetic Parameters by Visit – Plasma</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of CMAX by Visit</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpg03_cache/html/setup_94c44fb9c25940cebf487139c302e525">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkpg03_cache/html/plot1_3c6baeabe83ec66920e97c5056341af8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># filtered parameter</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CMAX"</span>, PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>use_title <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Boxplot of "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" by Visit"</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>use_subtitle <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Analyte:</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> SUBJID)) <span class="sc">+</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(AVISIT, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(AVAL <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(AVAL)<span class="sc">$</span>out),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">label =</span> SUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">labs</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">title =</span> use_title,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">caption =</span> use_footnote,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(<span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb2-26"><a href="#cb2-26"></a></span>
+<span id="cb2-27"><a href="#cb2-27"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg03_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpg03_cache/html/sessioninfo_e4680ae02faa30ed05d8d7150ca0f31c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      
+[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpg03_cache/html/snapshot_b886ce63b45a6e47e86cb1c95e9e0a24">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb5-2"><a href="#cb5-2"></a></span>
+<span id="cb5-3"><a href="#cb5-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb5-4"><a href="#cb5-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb5-5"><a href="#cb5-5"></a></span>
+<span id="cb5-6"><a href="#cb5-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb5-11"><a href="#cb5-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkpg03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+  const findCites = (el) => {
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+    if (parentEl) {
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+      if (cites) {
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+      }
+    } else {
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../graphs/pharmacokinetic/pkpg02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPG02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../graphs/pharmacokinetic/pkpg04.html" class="pagination-link">
+        <span class="nav-page-text">PKPG04</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb6" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb6-1"><a href="#cb6-1"></a><span class="co">---</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="an">title:</span><span class="co"> PKPG03</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="an">subtitle:</span><span class="co"> Box Plot of Pharmacokinetic Parameters by Visit -- Plasma</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="co">---</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>------------------------------------------------------------------------</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb6-9"><a href="#cb6-9"></a></span>
+<span id="cb6-10"><a href="#cb6-10"></a>::: panel-tabset</span>
+<span id="cb6-11"><a href="#cb6-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a></span>
+<span id="cb6-16"><a href="#cb6-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb6-17"><a href="#cb6-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-18"><a href="#cb6-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-19"><a href="#cb6-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb6-20"><a href="#cb6-20"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb6-21"><a href="#cb6-21"></a></span>
+<span id="cb6-22"><a href="#cb6-22"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb6-23"><a href="#cb6-23"></a><span class="in">```</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a></span>
+<span id="cb6-25"><a href="#cb6-25"></a><span class="fu">## Plot of CMAX by Visit</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a></span>
+<span id="cb6-27"><a href="#cb6-27"></a></span>
+<span id="cb6-28"><a href="#cb6-28"></a><span class="in">```{r plot1, warning=FALSE, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a><span class="co"># filtered parameter</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CMAX"</span>, PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>)</span>
+<span id="cb6-31"><a href="#cb6-31"></a></span>
+<span id="cb6-32"><a href="#cb6-32"></a>use_title <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Boxplot of "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" by Visit"</span>)</span>
+<span id="cb6-33"><a href="#cb6-33"></a>use_subtitle <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Analyte:</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb6-34"><a href="#cb6-34"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a></span>
+<span id="cb6-36"><a href="#cb6-36"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> SUBJID)) <span class="sc">+</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(AVISIT, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(AVAL <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(AVAL)<span class="sc">$</span>out),</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">label =</span> SUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)</span>
+<span id="cb6-44"><a href="#cb6-44"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>  <span class="fu">labs</span>(</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">title =</span> use_title,</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb6-48"><a href="#cb6-48"></a>    <span class="at">caption =</span> use_footnote,</span>
+<span id="cb6-49"><a href="#cb6-49"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb6-50"><a href="#cb6-50"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(<span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb6-51"><a href="#cb6-51"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-52"><a href="#cb6-52"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb6-54"><a href="#cb6-54"></a></span>
+<span id="cb6-55"><a href="#cb6-55"></a>plot</span>
+<span id="cb6-56"><a href="#cb6-56"></a><span class="in">```</span></span>
+<span id="cb6-57"><a href="#cb6-57"></a></span>
+<span id="cb6-58"><a href="#cb6-58"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb6-59"><a href="#cb6-59"></a></span>
+<span id="cb6-60"><a href="#cb6-60"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb6-61"><a href="#cb6-61"></a></span>
+<span id="cb6-62"><a href="#cb6-62"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPG04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Box Plot of Pharmacokinetic Parameters by Visit – Plasma</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot of CMAX by Visit</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpg04_cache/html/setup_3545be6d22539e21b97bc014119b9561">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(ggrepel)</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkpg04_cache/html/plot1_ca45d0abd571a6725f32e65517dccb31">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># filtered parameter</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(<span class="fu">toupper</span>(PARAMCD) <span class="sc">==</span> <span class="st">"CMAX"</span> <span class="sc">&amp;</span> <span class="fu">toupper</span>(PPSPEC) <span class="sc">==</span> <span class="st">"PLASMA"</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>use_title <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Boxplot of "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" by Visit"</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>use_subtitle <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Analyte:</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>p <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> SUBJID)) <span class="sc">+</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">geom_text_repel</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(AVISIT, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(AVAL <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(AVAL)<span class="sc">$</span>out),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">label =</span> SUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">labs</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">title =</span> use_title,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">caption =</span> use_footnote,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(<span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb2-26"><a href="#cb2-26"></a></span>
+<span id="cb2-27"><a href="#cb2-27"></a>plot <span class="ot">&lt;-</span> p <span class="sc">+</span> <span class="fu">geom_point</span>(<span class="fu">aes</span>(<span class="at">fill =</span> ACTARM), <span class="at">size =</span> <span class="dv">2</span>, <span class="at">shape =</span> <span class="dv">21</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>))</span>
+<span id="cb2-28"><a href="#cb2-28"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg04_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpg04_cache/html/sessioninfo_361ab8bc07430b140383bf0e54e672cc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  ggrepel_0.9.3    ggplot2_3.4.3    dplyr_1.1.3     
+[5] scda_0.1.6       tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[9] formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   
+ [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    
+ [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       
+[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     
+[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      
+[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      
+[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 
+[29] broom_1.0.5       vctrs_0.6.3       R6_2.5.1          lifecycle_1.0.3  
+[33] htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0      gtable_0.3.4     
+[37] glue_1.6.2        Rcpp_1.0.11       xfun_0.40         tibble_3.2.1     
+[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     
+[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  
+[49] compiler_4.3.1   </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpg04_cache/html/snapshot_7e2ccd3c37d5d9f21973a09649876356">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb5-2"><a href="#cb5-2"></a></span>
+<span id="cb5-3"><a href="#cb5-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb5-4"><a href="#cb5-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb5-5"><a href="#cb5-5"></a></span>
+<span id="cb5-6"><a href="#cb5-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb5-11"><a href="#cb5-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkpg04.lock">Download</a></p>
+</section>
+</div>
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+</div>
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../graphs/pharmacokinetic/pkpg03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPG03</span>
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+        <span class="nav-page-text">PKPG06</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb6" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb6-1"><a href="#cb6-1"></a><span class="co">---</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="an">title:</span><span class="co"> PKPG04</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="an">subtitle:</span><span class="co"> Box Plot of Pharmacokinetic Parameters by Visit -- Plasma</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="co">---</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>------------------------------------------------------------------------</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb6-9"><a href="#cb6-9"></a></span>
+<span id="cb6-10"><a href="#cb6-10"></a>::: panel-tabset</span>
+<span id="cb6-11"><a href="#cb6-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a></span>
+<span id="cb6-16"><a href="#cb6-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb6-17"><a href="#cb6-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-18"><a href="#cb6-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-19"><a href="#cb6-19"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb6-20"><a href="#cb6-20"></a><span class="fu">library</span>(ggrepel)</span>
+<span id="cb6-21"><a href="#cb6-21"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb6-22"><a href="#cb6-22"></a></span>
+<span id="cb6-23"><a href="#cb6-23"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb6-24"><a href="#cb6-24"></a><span class="in">```</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a></span>
+<span id="cb6-26"><a href="#cb6-26"></a><span class="fu">## Plot of CMAX by Visit</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a></span>
+<span id="cb6-28"><a href="#cb6-28"></a><span class="in">```{r plot1, warning=FALSE, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a><span class="co"># filtered parameter</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(<span class="fu">toupper</span>(PARAMCD) <span class="sc">==</span> <span class="st">"CMAX"</span> <span class="sc">&amp;</span> <span class="fu">toupper</span>(PPSPEC) <span class="sc">==</span> <span class="st">"PLASMA"</span>)</span>
+<span id="cb6-31"><a href="#cb6-31"></a></span>
+<span id="cb6-32"><a href="#cb6-32"></a>use_title <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Boxplot of "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" by Visit"</span>)</span>
+<span id="cb6-33"><a href="#cb6-33"></a>use_subtitle <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="st">"Analyte:</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb6-34"><a href="#cb6-34"></a>use_footnote <span class="ot">&lt;-</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a></span>
+<span id="cb6-36"><a href="#cb6-36"></a>p <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(adpp, <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> SUBJID)) <span class="sc">+</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a>  <span class="fu">geom_text_repel</span>(</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(AVISIT, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(AVAL <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(AVAL)<span class="sc">$</span>out),</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="fu">aes</span>(<span class="at">x =</span> AVISIT, <span class="at">y =</span> AVAL, <span class="at">label =</span> SUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)</span>
+<span id="cb6-44"><a href="#cb6-44"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>  <span class="fu">labs</span>(</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">title =</span> use_title,</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="at">subtitle =</span> use_subtitle,</span>
+<span id="cb6-48"><a href="#cb6-48"></a>    <span class="at">caption =</span> use_footnote,</span>
+<span id="cb6-49"><a href="#cb6-49"></a>    <span class="at">x =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb6-50"><a href="#cb6-50"></a>    <span class="at">y =</span> <span class="fu">paste0</span>(<span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>PARAM)), <span class="st">" ("</span>, <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp<span class="sc">$</span>AVALU)), <span class="st">")"</span>)</span>
+<span id="cb6-51"><a href="#cb6-51"></a>  ) <span class="sc">+</span></span>
+<span id="cb6-52"><a href="#cb6-52"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb6-54"><a href="#cb6-54"></a></span>
+<span id="cb6-55"><a href="#cb6-55"></a>plot <span class="ot">&lt;-</span> p <span class="sc">+</span> <span class="fu">geom_point</span>(<span class="fu">aes</span>(<span class="at">fill =</span> ACTARM), <span class="at">size =</span> <span class="dv">2</span>, <span class="at">shape =</span> <span class="dv">21</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>))</span>
+<span id="cb6-56"><a href="#cb6-56"></a>plot</span>
+<span id="cb6-57"><a href="#cb6-57"></a><span class="in">```</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a></span>
+<span id="cb6-59"><a href="#cb6-59"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb6-60"><a href="#cb6-60"></a></span>
+<span id="cb6-61"><a href="#cb6-61"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb6-62"><a href="#cb6-62"></a></span>
+<span id="cb6-63"><a href="#cb6-63"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/graphs/pharmacokinetic/pkpg04_files/figure-html/plot1-1.png b/stable/graphs/pharmacokinetic/pkpg04_files/figure-html/plot1-1.png
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPG06</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Boxplot of Metabolite to Parent Ratios by Treatment</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Plot with Whiskers at ±1.5 <br> Times Inter-Quartile Range</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Plot with Whiskers at <br> Minimum and Maximum Values</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Plot with Whiskers at <br> 5th and 95th Percentiles</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpg06_cache/html/setup_d16d4760040953607f4999296279ceca">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Filter NAs</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(PPSPEC <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PARAM <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PPCAT <span class="sc">!=</span> <span class="st">"NA"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CMAX"</span> <span class="sc">|</span> PARAMCD <span class="sc">==</span> <span class="st">"AUCIFO"</span>, AVISITN <span class="sc">==</span> <span class="dv">1</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># filter data by PPCAT and calculate ratio</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>anl_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Metabolite Drug X"</span>, <span class="st">"Plasma Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">pivot_wider</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, ACTARM, PARAMCD, AVISIT),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ratio =</span> <span class="st">`</span><span class="at">Metabolite Drug X</span><span class="st">`</span> <span class="sc">/</span> <span class="st">`</span><span class="at">Plasma Drug X</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(ratio), ratio <span class="sc">!=</span> <span class="cn">Inf</span>)</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a>anl_y <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Metabolite Drug Y"</span>, <span class="st">"Plasma Drug Y"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">pivot_wider</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, ACTARM, PARAMCD, AVISIT),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ratio =</span> <span class="st">`</span><span class="at">Metabolite Drug Y</span><span class="st">`</span> <span class="sc">/</span> <span class="st">`</span><span class="at">Plasma Drug Y</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(ratio), ratio <span class="sc">!=</span> <span class="cn">Inf</span>)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="co"># functions to calculate custom quantiles and outliers</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>quantiles <span class="ot">&lt;-</span> <span class="cf">function</span>(x) {</span>
+<span id="cb1-38"><a href="#cb1-38"></a>  quant <span class="ot">&lt;-</span> <span class="fu">quantile</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>))</span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">names</span>(quant) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ymin"</span>, <span class="st">"lower"</span>, <span class="st">"middle"</span>, <span class="st">"upper"</span>, <span class="st">"ymax"</span>)</span>
+<span id="cb1-40"><a href="#cb1-40"></a>  quant</span>
+<span id="cb1-41"><a href="#cb1-41"></a>}</span>
+<span id="cb1-42"><a href="#cb1-42"></a></span>
+<span id="cb1-43"><a href="#cb1-43"></a>outliers <span class="ot">&lt;-</span> <span class="cf">function</span>(x) {</span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">return</span>(x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, <span class="fl">0.05</span>) <span class="sc">|</span> x <span class="sc">&gt;</span> <span class="fu">quantile</span>(x, <span class="fl">0.95</span>))</span>
+<span id="cb1-45"><a href="#cb1-45"></a>}</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<section id="drug-x-boxplot" class="level4"><h4 class="anchored" data-anchor-id="drug-x-boxplot">Drug X Boxplot</h4>
+<div class="cell" data-test="{&quot;plot_v1&quot;:&quot;plot&quot;}" data-hash="pkpg06_cache/html/plot1_90f5a918e914911e979ac94354f6ecd4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ratio <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(ratio)<span class="sc">$</span>out),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">label =</span> USUBJID, <span class="at">col =</span> <span class="fu">factor</span>(ACTARM)),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">labs</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">+</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb2-19"><a href="#cb2-19"></a></span>
+<span id="cb2-20"><a href="#cb2-20"></a><span class="co"># PKPG06</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg06_files/figure-html/plot1-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section><section id="drug-y-boxplot" class="level4"><h4 class="anchored" data-anchor-id="drug-y-boxplot">Drug Y Boxplot</h4>
+<div class="cell" data-test="{&quot;plot_v2&quot;:&quot;plot&quot;}" data-hash="pkpg06_cache/html/plot2_2eed00466f718efc861b2c16c528e5cc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_y, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb3-6"><a href="#cb3-6"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ratio <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(ratio)<span class="sc">$</span>out),</span>
+<span id="cb3-7"><a href="#cb3-7"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">label =</span> USUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb3-8"><a href="#cb3-8"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb3-9"><a href="#cb3-9"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-10"><a href="#cb3-10"></a>  <span class="fu">labs</span>(</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug Y, Metabolite Drug Y "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_y<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_y<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb3-13"><a href="#cb3-13"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb3-14"><a href="#cb3-14"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb3-16"><a href="#cb3-16"></a>  ) <span class="sc">+</span></span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb3-18"><a href="#cb3-18"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb3-19"><a href="#cb3-19"></a></span>
+<span id="cb3-20"><a href="#cb3-20"></a><span class="co"># result</span></span>
+<span id="cb3-21"><a href="#cb3-21"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg06_files/figure-html/plot2-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;plot_v3&quot;:&quot;plot&quot;}" data-hash="pkpg06_cache/html/plot3_668f017ccc1dc51451613e83f66df9ee">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># whiskers are formed with the minimum and maximum values</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">0</span>) <span class="sc">+</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>, <span class="at">coef =</span> <span class="cn">NULL</span>) <span class="sc">+</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">labs</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">caption =</span> <span class="st">"Program:</span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  ) <span class="sc">+</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a><span class="co"># result</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg06_files/figure-html/plot3-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;plot_v4&quot;:&quot;plot&quot;}" data-hash="pkpg06_cache/html/plot4_c233b02b3f9ab7bc9c30d824618f458e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>anl_x_without_outliers <span class="ot">&lt;-</span> anl_x <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">outlier =</span> <span class="fu">ifelse</span>(<span class="fu">outliers</span>(ratio), ratio, <span class="fu">as.numeric</span>(<span class="cn">NA</span>)))</span>
+<span id="cb5-4"><a href="#cb5-4"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="fu">factor</span>(PARAMCD), ratio, <span class="at">fill =</span> <span class="fu">factor</span>(ACTARM), <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb5-6"><a href="#cb5-6"></a>    <span class="at">fun.data =</span> quantiles, <span class="at">geom =</span> <span class="st">"boxplot"</span>,</span>
+<span id="cb5-7"><a href="#cb5-7"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)</span>
+<span id="cb5-8"><a href="#cb5-8"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="at">fun.data =</span> quantiles, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)</span>
+<span id="cb5-13"><a href="#cb5-13"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a>  <span class="fu">geom_point</span>(</span>
+<span id="cb5-15"><a href="#cb5-15"></a>    <span class="at">data =</span> anl_x_without_outliers,</span>
+<span id="cb5-16"><a href="#cb5-16"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> outlier), <span class="at">na.rm =</span> T,</span>
+<span id="cb5-17"><a href="#cb5-17"></a>    <span class="at">size =</span> <span class="dv">2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb5-18"><a href="#cb5-18"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-19"><a href="#cb5-19"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb5-20"><a href="#cb5-20"></a>    <span class="at">data =</span> anl_x_without_outliers,</span>
+<span id="cb5-21"><a href="#cb5-21"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> outlier, <span class="at">label =</span> USUBJID, <span class="at">color =</span> ACTARM), <span class="at">na.rm =</span> T,</span>
+<span id="cb5-22"><a href="#cb5-22"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">vjust =</span> <span class="dv">1</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb5-23"><a href="#cb5-23"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-24"><a href="#cb5-24"></a>  <span class="fu">labs</span>(</span>
+<span id="cb5-25"><a href="#cb5-25"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb5-26"><a href="#cb5-26"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb5-27"><a href="#cb5-27"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb5-28"><a href="#cb5-28"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb5-29"><a href="#cb5-29"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb5-30"><a href="#cb5-30"></a>  ) <span class="sc">+</span></span>
+<span id="cb5-31"><a href="#cb5-31"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb5-32"><a href="#cb5-32"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb5-33"><a href="#cb5-33"></a></span>
+<span id="cb5-34"><a href="#cb5-34"></a><span class="co"># result</span></span>
+<span id="cb5-35"><a href="#cb5-35"></a>plot</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pkpg06_files/figure-html/plot4-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpg06_cache/html/teal_3256e0db1d8b6d1ed3cec4c3bdde0e79">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpg06_cache/html/sessioninfo_094e928333d5b7123463945bd01998fd">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] nestcolor_0.1.2  tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 tidyr_1.3.0      ggplot2_3.4.3    scda_0.1.6      
+[9] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  splines_4.3.1     scales_1.2.1     
+ [9] yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8    R6_2.5.1         
+[13] labeling_0.4.3    generics_0.1.3    knitr_1.44        rbibutils_2.2.15 
+[17] htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0   tibble_3.2.1     
+[21] munsell_0.5.0     pillar_1.9.0      rlang_1.1.1       utf8_1.2.3       
+[25] testthat_3.1.10   broom_1.0.5       xfun_0.40         cli_3.6.1        
+[29] withr_2.5.0       Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        farver_2.1.1      codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  rmarkdown_2.25    purrr_1.0.2      
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpg06_cache/html/snapshot_69307bceac9d6edbc8dc0ed55efb4ea4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/graphs/pharmacokinetic/pkpg06.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+      <a href="../../graphs/pharmacokinetic/pkpg04.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPG04</span>
+      </a>          
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> PKPG06</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Boxplot of Metabolite to Parent Ratios by Treatment</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(ggplot2)</span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb10-20"><a href="#cb10-20"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-21"><a href="#cb10-21"></a><span class="fu">library</span>(nestcolor)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a><span class="co"># Filter NAs</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>  <span class="fu">filter</span>(PPSPEC <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PARAM <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PPCAT <span class="sc">!=</span> <span class="st">"NA"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CMAX"</span> <span class="sc">|</span> PARAMCD <span class="sc">==</span> <span class="st">"AUCIFO"</span>, AVISITN <span class="sc">==</span> <span class="dv">1</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="co"># filter data by PPCAT and calculate ratio</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>anl_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Metabolite Drug X"</span>, <span class="st">"Plasma Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">pivot_wider</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, ACTARM, PARAMCD, AVISIT),</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb10-37"><a href="#cb10-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ratio =</span> <span class="st">`</span><span class="at">Metabolite Drug X</span><span class="st">`</span> <span class="sc">/</span> <span class="st">`</span><span class="at">Plasma Drug X</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(ratio), ratio <span class="sc">!=</span> <span class="cn">Inf</span>)</span>
+<span id="cb10-40"><a href="#cb10-40"></a></span>
+<span id="cb10-41"><a href="#cb10-41"></a>anl_y <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Metabolite Drug Y"</span>, <span class="st">"Plasma Drug Y"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>  <span class="fu">pivot_wider</span>(</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, ACTARM, PARAMCD, AVISIT),</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb10-47"><a href="#cb10-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ratio =</span> <span class="st">`</span><span class="at">Metabolite Drug Y</span><span class="st">`</span> <span class="sc">/</span> <span class="st">`</span><span class="at">Plasma Drug Y</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(ratio), ratio <span class="sc">!=</span> <span class="cn">Inf</span>)</span>
+<span id="cb10-50"><a href="#cb10-50"></a></span>
+<span id="cb10-51"><a href="#cb10-51"></a><span class="co"># functions to calculate custom quantiles and outliers</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>quantiles <span class="ot">&lt;-</span> <span class="cf">function</span>(x) {</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  quant <span class="ot">&lt;-</span> <span class="fu">quantile</span>(x, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.05</span>, <span class="fl">0.25</span>, <span class="fl">0.5</span>, <span class="fl">0.75</span>, <span class="fl">0.95</span>))</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="fu">names</span>(quant) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ymin"</span>, <span class="st">"lower"</span>, <span class="st">"middle"</span>, <span class="st">"upper"</span>, <span class="st">"ymax"</span>)</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  quant</span>
+<span id="cb10-56"><a href="#cb10-56"></a>}</span>
+<span id="cb10-57"><a href="#cb10-57"></a></span>
+<span id="cb10-58"><a href="#cb10-58"></a>outliers <span class="ot">&lt;-</span> <span class="cf">function</span>(x) {</span>
+<span id="cb10-59"><a href="#cb10-59"></a>  <span class="fu">return</span>(x <span class="sc">&lt;</span> <span class="fu">quantile</span>(x, <span class="fl">0.05</span>) <span class="sc">|</span> x <span class="sc">&gt;</span> <span class="fu">quantile</span>(x, <span class="fl">0.95</span>))</span>
+<span id="cb10-60"><a href="#cb10-60"></a>}</span>
+<span id="cb10-61"><a href="#cb10-61"></a><span class="in">```</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a></span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="fu">## Plot with Whiskers at ±1.5 &lt;br/&gt; Times Inter-Quartile Range</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="fu">#### Drug X Boxplot</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="in">```{r plot1, warning=FALSE, test = list(plot_v1 = "plot")}</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb10-73"><a href="#cb10-73"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ratio <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(ratio)<span class="sc">$</span>out),</span>
+<span id="cb10-74"><a href="#cb10-74"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">label =</span> USUBJID, <span class="at">col =</span> <span class="fu">factor</span>(ACTARM)),</span>
+<span id="cb10-75"><a href="#cb10-75"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb10-76"><a href="#cb10-76"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-77"><a href="#cb10-77"></a>  <span class="fu">labs</span>(</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb10-80"><a href="#cb10-80"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb10-82"><a href="#cb10-82"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb10-83"><a href="#cb10-83"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb10-85"><a href="#cb10-85"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb10-86"><a href="#cb10-86"></a></span>
+<span id="cb10-87"><a href="#cb10-87"></a><span class="co"># PKPG06</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a>plot</span>
+<span id="cb10-89"><a href="#cb10-89"></a><span class="in">```</span></span>
+<span id="cb10-90"><a href="#cb10-90"></a></span>
+<span id="cb10-91"><a href="#cb10-91"></a><span class="fu">#### Drug Y Boxplot</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a></span>
+<span id="cb10-93"><a href="#cb10-93"></a><span class="in">```{r plot2, warning=FALSE, test = list(plot_v2 = "plot")}</span></span>
+<span id="cb10-94"><a href="#cb10-94"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_y, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">2</span>) <span class="sc">+</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>) <span class="sc">+</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb10-99"><a href="#cb10-99"></a>    <span class="at">data =</span> . <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ratio <span class="sc">%in%</span> <span class="fu">boxplot.stats</span>(ratio)<span class="sc">$</span>out),</span>
+<span id="cb10-100"><a href="#cb10-100"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">label =</span> USUBJID, <span class="at">color =</span> ACTARM),</span>
+<span id="cb10-101"><a href="#cb10-101"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb10-102"><a href="#cb10-102"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-103"><a href="#cb10-103"></a>  <span class="fu">labs</span>(</span>
+<span id="cb10-104"><a href="#cb10-104"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb10-105"><a href="#cb10-105"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug Y, Metabolite Drug Y "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_y<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_y<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb10-106"><a href="#cb10-106"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb10-107"><a href="#cb10-107"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb10-108"><a href="#cb10-108"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb10-111"><a href="#cb10-111"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb10-112"><a href="#cb10-112"></a></span>
+<span id="cb10-113"><a href="#cb10-113"></a><span class="co"># result</span></span>
+<span id="cb10-114"><a href="#cb10-114"></a>plot</span>
+<span id="cb10-115"><a href="#cb10-115"></a><span class="in">```</span></span>
+<span id="cb10-116"><a href="#cb10-116"></a></span>
+<span id="cb10-117"><a href="#cb10-117"></a><span class="fu">## Plot with Whiskers at &lt;br/&gt; Minimum and Maximum Values</span></span>
+<span id="cb10-118"><a href="#cb10-118"></a></span>
+<span id="cb10-119"><a href="#cb10-119"></a><span class="in">```{r plot3, warning=FALSE, test = list(plot_v3 = "plot")}</span></span>
+<span id="cb10-120"><a href="#cb10-120"></a><span class="co"># whiskers are formed with the minimum and maximum values</span></span>
+<span id="cb10-121"><a href="#cb10-121"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> ratio, <span class="at">fill =</span> ACTARM, <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb10-122"><a href="#cb10-122"></a>  <span class="fu">geom_boxplot</span>(<span class="at">outlier.size =</span> <span class="dv">0</span>) <span class="sc">+</span></span>
+<span id="cb10-123"><a href="#cb10-123"></a>  <span class="fu">stat_boxplot</span>(<span class="at">geom =</span> <span class="st">"errorbar"</span>, <span class="at">coef =</span> <span class="cn">NULL</span>) <span class="sc">+</span></span>
+<span id="cb10-124"><a href="#cb10-124"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="fl">0.75</span>)) <span class="sc">+</span></span>
+<span id="cb10-125"><a href="#cb10-125"></a>  <span class="fu">labs</span>(</span>
+<span id="cb10-126"><a href="#cb10-126"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb10-127"><a href="#cb10-127"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>    <span class="at">caption =</span> <span class="st">"Program:</span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb10-129"><a href="#cb10-129"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb10-130"><a href="#cb10-130"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb10-131"><a href="#cb10-131"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-132"><a href="#cb10-132"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb10-134"><a href="#cb10-134"></a></span>
+<span id="cb10-135"><a href="#cb10-135"></a><span class="co"># result</span></span>
+<span id="cb10-136"><a href="#cb10-136"></a>plot</span>
+<span id="cb10-137"><a href="#cb10-137"></a><span class="in">```</span></span>
+<span id="cb10-138"><a href="#cb10-138"></a></span>
+<span id="cb10-139"><a href="#cb10-139"></a><span class="fu">## Plot with Whiskers at &lt;br/&gt; 5th and 95th Percentiles</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a></span>
+<span id="cb10-141"><a href="#cb10-141"></a><span class="in">```{r plot4, warning=FALSE, test = list(plot_v4 = "plot")}</span></span>
+<span id="cb10-142"><a href="#cb10-142"></a>anl_x_without_outliers <span class="ot">&lt;-</span> anl_x <span class="sc">%&gt;%</span></span>
+<span id="cb10-143"><a href="#cb10-143"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(PARAMCD, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb10-144"><a href="#cb10-144"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">outlier =</span> <span class="fu">ifelse</span>(<span class="fu">outliers</span>(ratio), ratio, <span class="fu">as.numeric</span>(<span class="cn">NA</span>)))</span>
+<span id="cb10-145"><a href="#cb10-145"></a>plot <span class="ot">&lt;-</span> <span class="fu">ggplot</span>(anl_x, <span class="fu">aes</span>(<span class="fu">factor</span>(PARAMCD), ratio, <span class="at">fill =</span> <span class="fu">factor</span>(ACTARM), <span class="at">label =</span> USUBJID)) <span class="sc">+</span></span>
+<span id="cb10-146"><a href="#cb10-146"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb10-147"><a href="#cb10-147"></a>    <span class="at">fun.data =</span> quantiles, <span class="at">geom =</span> <span class="st">"boxplot"</span>,</span>
+<span id="cb10-148"><a href="#cb10-148"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)</span>
+<span id="cb10-149"><a href="#cb10-149"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-150"><a href="#cb10-150"></a>  <span class="fu">stat_summary</span>(<span class="at">geom =</span> <span class="st">"point"</span>, <span class="at">fun =</span> <span class="st">"mean"</span>, <span class="at">col =</span> <span class="st">"black"</span>, <span class="at">size =</span> <span class="dv">5</span>, <span class="at">shape =</span> <span class="dv">8</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)) <span class="sc">+</span></span>
+<span id="cb10-151"><a href="#cb10-151"></a>  <span class="fu">stat_summary</span>(</span>
+<span id="cb10-152"><a href="#cb10-152"></a>    <span class="at">fun.data =</span> quantiles, <span class="at">geom =</span> <span class="st">"errorbar"</span>,</span>
+<span id="cb10-153"><a href="#cb10-153"></a>    <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>)</span>
+<span id="cb10-154"><a href="#cb10-154"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-155"><a href="#cb10-155"></a>  <span class="fu">geom_point</span>(</span>
+<span id="cb10-156"><a href="#cb10-156"></a>    <span class="at">data =</span> anl_x_without_outliers,</span>
+<span id="cb10-157"><a href="#cb10-157"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> outlier), <span class="at">na.rm =</span> T,</span>
+<span id="cb10-158"><a href="#cb10-158"></a>    <span class="at">size =</span> <span class="dv">2</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb10-159"><a href="#cb10-159"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-160"><a href="#cb10-160"></a>  <span class="fu">geom_text</span>(</span>
+<span id="cb10-161"><a href="#cb10-161"></a>    <span class="at">data =</span> anl_x_without_outliers,</span>
+<span id="cb10-162"><a href="#cb10-162"></a>    <span class="fu">aes</span>(<span class="at">x =</span> PARAMCD, <span class="at">y =</span> outlier, <span class="at">label =</span> USUBJID, <span class="at">color =</span> ACTARM), <span class="at">na.rm =</span> T,</span>
+<span id="cb10-163"><a href="#cb10-163"></a>    <span class="at">size =</span> <span class="dv">3</span>, <span class="at">hjust =</span> <span class="sc">-</span><span class="fl">0.2</span>, <span class="at">vjust =</span> <span class="dv">1</span>, <span class="at">position =</span> <span class="fu">position_dodge</span>(<span class="dv">1</span>), <span class="at">show.legend =</span> F</span>
+<span id="cb10-164"><a href="#cb10-164"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-165"><a href="#cb10-165"></a>  <span class="fu">labs</span>(</span>
+<span id="cb10-166"><a href="#cb10-166"></a>    <span class="at">title =</span> <span class="st">"Boxplot of Metabolite to Parent Ratios by Treatment"</span>,</span>
+<span id="cb10-167"><a href="#cb10-167"></a>    <span class="at">subtitle =</span> <span class="fu">paste0</span>(<span class="st">"Analyte: Plasma Drug X, Metabolite Drug X "</span>, <span class="st">"</span><span class="sc">\n</span><span class="st">PK Parameter: "</span>, <span class="fu">as.character</span>(<span class="fu">paste</span>(<span class="fu">unique</span>(anl_x<span class="sc">$</span>PARAMCD), <span class="at">collapse =</span> <span class="st">", "</span>)), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">as.character</span>((<span class="fu">unique</span>(anl_x<span class="sc">$</span>AVISIT)))),</span>
+<span id="cb10-168"><a href="#cb10-168"></a>    <span class="at">caption =</span> <span class="st">"Program: </span><span class="sc">\n</span><span class="st">Output:"</span>,</span>
+<span id="cb10-169"><a href="#cb10-169"></a>    <span class="at">x =</span> <span class="st">"Parameter"</span>,</span>
+<span id="cb10-170"><a href="#cb10-170"></a>    <span class="at">y =</span> <span class="st">"Metabolite to Parent Ratio"</span></span>
+<span id="cb10-171"><a href="#cb10-171"></a>  ) <span class="sc">+</span></span>
+<span id="cb10-172"><a href="#cb10-172"></a>  <span class="fu">theme</span>(<span class="at">plot.caption =</span> <span class="fu">element_text</span>(<span class="at">hjust =</span> <span class="dv">0</span>)) <span class="sc">+</span></span>
+<span id="cb10-173"><a href="#cb10-173"></a>  <span class="fu">theme_nest</span>()</span>
+<span id="cb10-174"><a href="#cb10-174"></a></span>
+<span id="cb10-175"><a href="#cb10-175"></a><span class="co"># result</span></span>
+<span id="cb10-176"><a href="#cb10-176"></a>plot</span>
+<span id="cb10-177"><a href="#cb10-177"></a><span class="in">```</span></span>
+<span id="cb10-178"><a href="#cb10-178"></a></span>
+<span id="cb10-179"><a href="#cb10-179"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-180"><a href="#cb10-180"></a></span>
+<span id="cb10-181"><a href="#cb10-181"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-182"><a href="#cb10-182"></a></span>
+<span id="cb10-183"><a href="#cb10-183"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-184"><a href="#cb10-184"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-185"><a href="#cb10-185"></a></span>
+<span id="cb10-186"><a href="#cb10-186"></a><span class="co"># In progress</span></span>
+<span id="cb10-187"><a href="#cb10-187"></a><span class="in">```</span></span>
+<span id="cb10-188"><a href="#cb10-188"></a></span>
+<span id="cb10-189"><a href="#cb10-189"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-190"><a href="#cb10-190"></a></span>
+<span id="cb10-191"><a href="#cb10-191"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
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diff --git a/stable/index.html b/stable/index.html
new file mode 100644
index 0000000000..5e4cc56bb5
--- /dev/null
+++ b/stable/index.html
@@ -0,0 +1,1911 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+
+
+<title>TLG Catalog</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+
+<script src="site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="site_libs/clipboard/clipboard.min.js"></script>
+<script src="site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="site_libs/quarto-search/fuse.min.js"></script>
+<script src="site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="./">
+<link href="./assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="site_libs/quarto-html/quarto.js"></script>
+<script src="site_libs/quarto-html/popper.min.js"></script>
+<script src="site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="site_libs/quarto-html/anchor.min.js"></script>
+<link href="site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark">
+<script id="quarto-search-options" type="application/json">{
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+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
+    "search-label": "Search"
+  }
+}</script>
+
+<script type="text/plain" cookie-consent="tracking">
+
+(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){
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+  })(window,document,'script','https://www.google-analytics.com/analytics.js','ga');
+ga('create', 'UA-125641273-1', 'auto');
+
+ga('send', {
+  hitType: 'pageview',
+  'anonymizeIp': true,
+});
+</script>
+
+<script type="text/javascript" charset="UTF-8">
+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
+  });
+});
+</script> 
+  
+<style>html{ scroll-behavior: smooth; }</style>
+
+
+<link rel="stylesheet" href="assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog">
+<meta property="og:description" content="Tables, Listings, and Graphs Catalog">
+<meta property="og:image" content="https://insightsengineering.github.io/tlg-catalog/assets/img/tlgc.png">
+<meta property="og:site-name" content="TLG Catalog">
+<meta property="og:image:height" content="1501">
+<meta property="og:image:width" content="1299">
+</head>
+
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top">
+    <nav class="navbar navbar-expand navbar-dark ">
+      <div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="./index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">    
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/development" rel="" target="">
+ <span class="dropdown-text">Development</span></a>
+  </li>  
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+  </li>
+</ul>
+          <div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav>
+  <nav class="quarto-secondary-nav">
+    <div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item"><a href="./index.html">Introduction</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav>
+</header>
+<!-- content -->
+<div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto">
+    <div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="./index.html" class="sidebar-logo-link">
+      <img src="./assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none">
+      </a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./index.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+    </div>
+</nav>
+<div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content">
+
+<header id="title-block-header" class="quarto-title-block default">
+<div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">TLG Catalog</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Tables, Listings, and Graphs Catalog</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header>
+
+<p><img src="./assets/img/tlgc.png" style="float: right;" width="200;"></p>
+<section id="introduction" class="level2">
+<h2 class="anchored" data-anchor-id="introduction">Introduction</h2>
+<p>A catalog of Tables, Listings, and Graphs output produced by NEST tools.</p>
+<p><strong>See the full index of available TLG templates on the <a href="./tlg-index.html">Index page</a>.</strong></p>
+</section>
+<section id="license" class="level2">
+<h2 class="anchored" data-anchor-id="license">License</h2>
+<p>This catalog as well as code examples are licensed under the Apache License, Version 2.0.</p>
+
+
+<!-- -->
+
+</section>
+
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+</script>
+<script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb1" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb1-1"><a href="#cb1-1"></a><span class="co">---</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="an">title:</span><span class="co"> "TLG Catalog"</span></span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="an">subtitle:</span><span class="co"> "Tables, Listings, and Graphs Catalog"</span></span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="co">---</span></span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="kw">&lt;img</span> <span class="er">src</span><span class="ot">=</span><span class="st">"./assets/img/tlgc.png"</span> <span class="er">style</span><span class="ot">=</span><span class="st">"float: right;"</span> <span class="er">width</span><span class="ot">=</span><span class="st">"200;"</span><span class="kw">/&gt;</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="fu">## Introduction</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a>A catalog of Tables, Listings, and Graphs output produced by NEST tools.</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>**See the full index of available TLG templates on the [Index page](tlg-index.qmd).**</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="fu">## License</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a></span>
+<span id="cb1-16"><a href="#cb1-16"></a>This catalog as well as code examples are licensed under the Apache License, Version 2.0.</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer">
+  <div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+
+<script src="site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/ADA/adal02.html b/stable/listings/ADA/adal02.html
new file mode 100644
index 0000000000..863285de33
--- /dev/null
+++ b/stable/listings/ADA/adal02.html
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - ADAL02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
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+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
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+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - ADAL02">
+<meta property="og:description" content="Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients">
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+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
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+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
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+  <i class="bi"></i>
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+</a>
+</div>
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+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/ADA/adal02.html">ADA</a></li><li class="breadcrumb-item"><a href="../../listings/ADA/adal02.html">ADAL02</a></li></ol></nav>
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+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
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+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="true">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAL02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adal02_cache/html/setup_c5bfef730483bbd1526c8ad9bd7b7336">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>  <span class="fu">filter</span>(NFRLT <span class="sc">%%</span> <span class="dv">1</span> <span class="sc">==</span> <span class="dv">0</span> <span class="sc">&amp;</span> NFRLT <span class="sc">&gt;</span> <span class="dv">0</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>trt <span class="ot">&lt;-</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"A: Drug X Antibody"</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>drugcd <span class="ot">&lt;-</span> <span class="fu">unique</span>(adab<span class="sc">$</span>PARAMCD[adab<span class="sc">$</span>PARAM <span class="sc">==</span> <span class="st">"Antibody titer units"</span>])[<span class="dv">1</span>]</span>
+<span id="cb1-11"><a href="#cb1-11"></a>min_titer <span class="ot">&lt;-</span> <span class="fl">1.10</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adab_x <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    ARM <span class="sc">==</span> trt,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    PARCAT1 <span class="sc">==</span> drug_a,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">filter</span>(<span class="fu">if_any</span>(<span class="fu">matches</span>(<span class="st">"Treatment Emergent - Positive"</span>), <span class="sc">~</span> .x <span class="sc">==</span> <span class="dv">1</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="co"># filter(`Treatment Emergent - Positive` == 1) %&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">VISN =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      VISIT, <span class="st">"</span><span class="sc">\n</span><span class="st">(Day "</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>        NFRLT <span class="sc">%%</span> <span class="dv">1</span> <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>        NFRLT,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>        <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(NFRLT, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      ),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      <span class="st">")"</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>    )),</span>
+<span id="cb1-37"><a href="#cb1-37"></a>    <span class="at">PTES =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="fu">ifelse</span>(<span class="st">"Treatment induced ADA"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>, F),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb1-40"><a href="#cb1-40"></a>        <span class="st">"Transient ADA"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.) <span class="sc">&amp;</span> <span class="st">`</span><span class="at">Transient ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>        <span class="st">"Induced (Transient)"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>        <span class="st">"Induced (Persistent)"</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>      ),</span>
+<span id="cb1-44"><a href="#cb1-44"></a>      <span class="st">"Enhanced"</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>    )</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">AVAL =</span> <span class="fu">paste0</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb1-50"><a href="#cb1-50"></a>        <span class="fu">ifelse</span>(<span class="st">"ADA interpreted per sample result"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">0</span>, F),</span>
+<span id="cb1-51"><a href="#cb1-51"></a>        <span class="st">"NEGATIVE"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>        <span class="fu">ifelse</span>(</span>
+<span id="cb1-53"><a href="#cb1-53"></a>          <span class="fu">ifelse</span>(<span class="st">"Antibody titer units"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="sc">!</span><span class="fu">is.na</span>(<span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span>), F),</span>
+<span id="cb1-54"><a href="#cb1-54"></a>          <span class="fu">ifelse</span>(</span>
+<span id="cb1-55"><a href="#cb1-55"></a>            <span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span> <span class="sc">&lt;</span> min_titer,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>            <span class="fu">paste0</span>(<span class="st">"&lt;"</span>, <span class="fu">format</span>(min_titer, <span class="at">nsmall =</span> <span class="dv">2</span>)),</span>
+<span id="cb1-57"><a href="#cb1-57"></a>            <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(<span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span>, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb1-58"><a href="#cb1-58"></a>          ),</span>
+<span id="cb1-59"><a href="#cb1-59"></a>          <span class="st">"---"</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>        )</span>
+<span id="cb1-61"><a href="#cb1-61"></a>      ),</span>
+<span id="cb1-62"><a href="#cb1-62"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb1-63"><a href="#cb1-63"></a>        <span class="fu">ifelse</span>(<span class="st">"NAB interpreted per sample result"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>, F),</span>
+<span id="cb1-64"><a href="#cb1-64"></a>        <span class="st">"*"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>        <span class="st">""</span></span>
+<span id="cb1-66"><a href="#cb1-66"></a>      )</span>
+<span id="cb1-67"><a href="#cb1-67"></a>    )</span>
+<span id="cb1-68"><a href="#cb1-68"></a>  )</span>
+<span id="cb1-69"><a href="#cb1-69"></a></span>
+<span id="cb1-70"><a href="#cb1-70"></a>out <span class="ot">&lt;-</span> adab_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-71"><a href="#cb1-71"></a>  <span class="fu">select</span>(USUBJID, VISN, AVAL, PTES) <span class="sc">%&gt;%</span></span>
+<span id="cb1-72"><a href="#cb1-72"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-73"><a href="#cb1-73"></a>    <span class="at">names_from =</span> VISN,</span>
+<span id="cb1-74"><a href="#cb1-74"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-75"><a href="#cb1-75"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-76"><a href="#cb1-76"></a>  <span class="fu">select</span>(USUBJID, <span class="fu">unique</span>(adab_x<span class="sc">$</span>VISN[<span class="fu">order</span>(adab_x<span class="sc">$</span>NFRLT)]), PTES)</span>
+<span id="cb1-77"><a href="#cb1-77"></a></span>
+<span id="cb1-78"><a href="#cb1-78"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-79"><a href="#cb1-79"></a></span>
+<span id="cb1-80"><a href="#cb1-80"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-81"><a href="#cb1-81"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-82"><a href="#cb1-82"></a>    <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb1-83"><a href="#cb1-83"></a>    <span class="at">PTES =</span> <span class="st">"Patient Treatment</span><span class="sc">\n</span><span class="st">Emergent ADA Status"</span></span>
+<span id="cb1-84"><a href="#cb1-84"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="adal02_cache/html/lsting_f21329fe4763d002f94c142fa9d24649">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"Listing of Anti-"</span>, drugcd, <span class="st">" Antibody Data for Treatment Emergent ADA Positive Patients, PK Population"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="st">"</span><span class="sc">\n</span><span class="st">Protocol: "</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>]</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Treatment Group:"</span>, trt),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">main_footer =</span> <span class="st">"Minimum reportable titer = 1.10 (example only)</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a><span class="st">--- = No sample evaluated</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a><span class="st">ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies)</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a><span class="st">Number of patients positive for Treatment Emergent ADA = the number of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a><span class="st">Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a><span class="st">Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a><span class="st">Transient ADA = ADA positive result detected (a) at only one post-baseline sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints during treatment where the first and last ADA positive samples  are separated by a period of &lt; 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a><span class="st">Persistent ADA =  ADA positive result detected (a) at the last post-baseline sampling timepoint, OR (b) at 2 or more time points during treatment where the first and last ADA positive samples are separated by a period ≥ 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a><span class="st">Asterisk denotes sample that tested positive for Neutralizing Antibodies."</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Anti-R1800000 Antibody Data for Treatment Emergent ADA Positive Patients, PK Population
+Protocol: A: Drug X Antibody
+
+Treatment Group: A: Drug X
+
+—————————————————————————————————————————————————————
+                         Day 2     Patient Treatment 
+     Subject ID         (Day 1)   Emergent ADA Status
+—————————————————————————————————————————————————————
+AB12345-BRA-1-id-105      ---          Enhanced      
+AB12345-BRA-1-id-134      ---          Enhanced      
+ AB12345-BRA-1-id-42      ---          Enhanced      
+ AB12345-BRA-1-id-93      ---          Enhanced      
+AB12345-BRA-11-id-217     ---          Enhanced      
+AB12345-BRA-11-id-345     ---          Enhanced      
+AB12345-BRA-11-id-397     ---          Enhanced      
+AB12345-BRA-11-id-50      ---          Enhanced      
+AB12345-BRA-13-id-177     ---          Enhanced      
+AB12345-BRA-14-id-23      ---          Enhanced      
+AB12345-BRA-15-id-36      ---          Enhanced      
+AB12345-BRA-2-id-296      ---          Enhanced      
+AB12345-BRA-6-id-369      ---          Enhanced      
+ AB12345-CAN-1-id-18      ---          Enhanced      
+AB12345-CAN-11-id-139     ---          Enhanced      
+AB12345-CAN-14-id-104     ---          Enhanced      
+AB12345-CHN-1-id-119      ---          Enhanced      
+AB12345-CHN-1-id-123      ---          Enhanced      
+AB12345-CHN-1-id-133      ---          Enhanced      
+AB12345-CHN-1-id-199      ---          Enhanced      
+—————————————————————————————————————————————————————
+
+Minimum reportable titer = 1.10 (example only)
+--- = No sample evaluated
+ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies)
+Number of patients positive for Treatment Emergent ADA = the number of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.
+Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.
+Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.
+Transient ADA = ADA positive result detected (a) at only one post-baseline sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints during treatment where the first and last ADA positive samples  are separated by a period of &lt; 16 weeks, irrespective of any negative samples in between.
+Persistent ADA =  ADA positive result detected (a) at the last post-baseline sampling timepoint, OR (b) at 2 or more time points during treatment where the first and last ADA positive samples are separated by a period ≥ 16 weeks, irrespective of any negative samples in between.
+Asterisk denotes sample that tested positive for Neutralizing Antibodies.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adal02_cache/html/sessioninfo_f28b883eb204bca2e63c1637a6fffc8f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adal02_cache/html/snapshot_96956d937d3b1a489925994e3e8aecf3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/ADA/adal02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> ADAL02</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>  <span class="fu">filter</span>(NFRLT <span class="sc">%%</span> <span class="dv">1</span> <span class="sc">==</span> <span class="dv">0</span> <span class="sc">&amp;</span> NFRLT <span class="sc">&gt;</span> <span class="dv">0</span>)</span>
+<span id="cb9-22"><a href="#cb9-22"></a></span>
+<span id="cb9-23"><a href="#cb9-23"></a>trt <span class="ot">&lt;-</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"A: Drug X Antibody"</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a>drugcd <span class="ot">&lt;-</span> <span class="fu">unique</span>(adab<span class="sc">$</span>PARAMCD[adab<span class="sc">$</span>PARAM <span class="sc">==</span> <span class="st">"Antibody titer units"</span>])[<span class="dv">1</span>]</span>
+<span id="cb9-26"><a href="#cb9-26"></a>min_titer <span class="ot">&lt;-</span> <span class="fl">1.10</span></span>
+<span id="cb9-27"><a href="#cb9-27"></a></span>
+<span id="cb9-28"><a href="#cb9-28"></a>adab_x <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-30"><a href="#cb9-30"></a>    ARM <span class="sc">==</span> trt,</span>
+<span id="cb9-31"><a href="#cb9-31"></a>    PARCAT1 <span class="sc">==</span> drug_a,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-37"><a href="#cb9-37"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="fu">filter</span>(<span class="fu">if_any</span>(<span class="fu">matches</span>(<span class="st">"Treatment Emergent - Positive"</span>), <span class="sc">~</span> .x <span class="sc">==</span> <span class="dv">1</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="co"># filter(`Treatment Emergent - Positive` == 1) %&gt;%</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-43"><a href="#cb9-43"></a>    <span class="at">VISN =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(</span>
+<span id="cb9-44"><a href="#cb9-44"></a>      VISIT, <span class="st">"</span><span class="sc">\n</span><span class="st">(Day "</span>,</span>
+<span id="cb9-45"><a href="#cb9-45"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb9-46"><a href="#cb9-46"></a>        NFRLT <span class="sc">%%</span> <span class="dv">1</span> <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb9-47"><a href="#cb9-47"></a>        NFRLT,</span>
+<span id="cb9-48"><a href="#cb9-48"></a>        <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(NFRLT, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb9-49"><a href="#cb9-49"></a>      ),</span>
+<span id="cb9-50"><a href="#cb9-50"></a>      <span class="st">")"</span></span>
+<span id="cb9-51"><a href="#cb9-51"></a>    )),</span>
+<span id="cb9-52"><a href="#cb9-52"></a>    <span class="at">PTES =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb9-53"><a href="#cb9-53"></a>      <span class="fu">ifelse</span>(<span class="st">"Treatment induced ADA"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>, F),</span>
+<span id="cb9-54"><a href="#cb9-54"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb9-55"><a href="#cb9-55"></a>        <span class="st">"Transient ADA"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.) <span class="sc">&amp;</span> <span class="st">`</span><span class="at">Transient ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb9-56"><a href="#cb9-56"></a>        <span class="st">"Induced (Transient)"</span>,</span>
+<span id="cb9-57"><a href="#cb9-57"></a>        <span class="st">"Induced (Persistent)"</span></span>
+<span id="cb9-58"><a href="#cb9-58"></a>      ),</span>
+<span id="cb9-59"><a href="#cb9-59"></a>      <span class="st">"Enhanced"</span></span>
+<span id="cb9-60"><a href="#cb9-60"></a>    )</span>
+<span id="cb9-61"><a href="#cb9-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-62"><a href="#cb9-62"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-63"><a href="#cb9-63"></a>    <span class="at">AVAL =</span> <span class="fu">paste0</span>(</span>
+<span id="cb9-64"><a href="#cb9-64"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb9-65"><a href="#cb9-65"></a>        <span class="fu">ifelse</span>(<span class="st">"ADA interpreted per sample result"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">0</span>, F),</span>
+<span id="cb9-66"><a href="#cb9-66"></a>        <span class="st">"NEGATIVE"</span>,</span>
+<span id="cb9-67"><a href="#cb9-67"></a>        <span class="fu">ifelse</span>(</span>
+<span id="cb9-68"><a href="#cb9-68"></a>          <span class="fu">ifelse</span>(<span class="st">"Antibody titer units"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="sc">!</span><span class="fu">is.na</span>(<span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span>), F),</span>
+<span id="cb9-69"><a href="#cb9-69"></a>          <span class="fu">ifelse</span>(</span>
+<span id="cb9-70"><a href="#cb9-70"></a>            <span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span> <span class="sc">&lt;</span> min_titer,</span>
+<span id="cb9-71"><a href="#cb9-71"></a>            <span class="fu">paste0</span>(<span class="st">"&lt;"</span>, <span class="fu">format</span>(min_titer, <span class="at">nsmall =</span> <span class="dv">2</span>)),</span>
+<span id="cb9-72"><a href="#cb9-72"></a>            <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(<span class="st">`</span><span class="at">Antibody titer units</span><span class="st">`</span>, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb9-73"><a href="#cb9-73"></a>          ),</span>
+<span id="cb9-74"><a href="#cb9-74"></a>          <span class="st">"---"</span></span>
+<span id="cb9-75"><a href="#cb9-75"></a>        )</span>
+<span id="cb9-76"><a href="#cb9-76"></a>      ),</span>
+<span id="cb9-77"><a href="#cb9-77"></a>      <span class="fu">ifelse</span>(</span>
+<span id="cb9-78"><a href="#cb9-78"></a>        <span class="fu">ifelse</span>(<span class="st">"NAB interpreted per sample result"</span> <span class="sc">%in%</span> <span class="fu">names</span>(.), <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="dv">1</span>, F),</span>
+<span id="cb9-79"><a href="#cb9-79"></a>        <span class="st">"*"</span>,</span>
+<span id="cb9-80"><a href="#cb9-80"></a>        <span class="st">""</span></span>
+<span id="cb9-81"><a href="#cb9-81"></a>      )</span>
+<span id="cb9-82"><a href="#cb9-82"></a>    )</span>
+<span id="cb9-83"><a href="#cb9-83"></a>  )</span>
+<span id="cb9-84"><a href="#cb9-84"></a></span>
+<span id="cb9-85"><a href="#cb9-85"></a>out <span class="ot">&lt;-</span> adab_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-86"><a href="#cb9-86"></a>  <span class="fu">select</span>(USUBJID, VISN, AVAL, PTES) <span class="sc">%&gt;%</span></span>
+<span id="cb9-87"><a href="#cb9-87"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-88"><a href="#cb9-88"></a>    <span class="at">names_from =</span> VISN,</span>
+<span id="cb9-89"><a href="#cb9-89"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb9-90"><a href="#cb9-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-91"><a href="#cb9-91"></a>  <span class="fu">select</span>(USUBJID, <span class="fu">unique</span>(adab_x<span class="sc">$</span>VISN[<span class="fu">order</span>(adab_x<span class="sc">$</span>NFRLT)]), PTES)</span>
+<span id="cb9-92"><a href="#cb9-92"></a></span>
+<span id="cb9-93"><a href="#cb9-93"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-94"><a href="#cb9-94"></a></span>
+<span id="cb9-95"><a href="#cb9-95"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb9-96"><a href="#cb9-96"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb9-97"><a href="#cb9-97"></a>    <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb9-98"><a href="#cb9-98"></a>    <span class="at">PTES =</span> <span class="st">"Patient Treatment</span><span class="sc">\n</span><span class="st">Emergent ADA Status"</span></span>
+<span id="cb9-99"><a href="#cb9-99"></a>  )</span>
+<span id="cb9-100"><a href="#cb9-100"></a><span class="in">```</span></span>
+<span id="cb9-101"><a href="#cb9-101"></a></span>
+<span id="cb9-102"><a href="#cb9-102"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-103"><a href="#cb9-103"></a></span>
+<span id="cb9-104"><a href="#cb9-104"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-105"><a href="#cb9-105"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-106"><a href="#cb9-106"></a>  out,</span>
+<span id="cb9-107"><a href="#cb9-107"></a>  <span class="at">key_cols =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb9-108"><a href="#cb9-108"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-109"><a href="#cb9-109"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb9-110"><a href="#cb9-110"></a>    <span class="st">"Listing of Anti-"</span>, drugcd, <span class="st">" Antibody Data for Treatment Emergent ADA Positive Patients, PK Population"</span>,</span>
+<span id="cb9-111"><a href="#cb9-111"></a>    <span class="st">"</span><span class="sc">\n</span><span class="st">Protocol: "</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>]</span>
+<span id="cb9-112"><a href="#cb9-112"></a>  ),</span>
+<span id="cb9-113"><a href="#cb9-113"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Treatment Group:"</span>, trt),</span>
+<span id="cb9-114"><a href="#cb9-114"></a>  <span class="at">main_footer =</span> <span class="st">"Minimum reportable titer = 1.10 (example only)</span></span>
+<span id="cb9-115"><a href="#cb9-115"></a><span class="st">--- = No sample evaluated</span></span>
+<span id="cb9-116"><a href="#cb9-116"></a><span class="st">ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies)</span></span>
+<span id="cb9-117"><a href="#cb9-117"></a><span class="st">Number of patients positive for Treatment Emergent ADA = the number of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.</span></span>
+<span id="cb9-118"><a href="#cb9-118"></a><span class="st">Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb9-119"><a href="#cb9-119"></a><span class="st">Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb9-120"><a href="#cb9-120"></a><span class="st">Transient ADA = ADA positive result detected (a) at only one post-baseline sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints during treatment where the first and last ADA positive samples  are separated by a period of &lt; 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb9-121"><a href="#cb9-121"></a><span class="st">Persistent ADA =  ADA positive result detected (a) at the last post-baseline sampling timepoint, OR (b) at 2 or more time points during treatment where the first and last ADA positive samples are separated by a period ≥ 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb9-122"><a href="#cb9-122"></a><span class="st">Asterisk denotes sample that tested positive for Neutralizing Antibodies."</span></span>
+<span id="cb9-123"><a href="#cb9-123"></a>)</span>
+<span id="cb9-124"><a href="#cb9-124"></a></span>
+<span id="cb9-125"><a href="#cb9-125"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-126"><a href="#cb9-126"></a><span class="in">```</span></span>
+<span id="cb9-127"><a href="#cb9-127"></a></span>
+<span id="cb9-128"><a href="#cb9-128"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-129"><a href="#cb9-129"></a></span>
+<span id="cb9-130"><a href="#cb9-130"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-131"><a href="#cb9-131"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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new file mode 100644
index 0000000000..68057f3666
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET06_SMQ</span></a>
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+ <span class="menu-text">AET09</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">Deaths</span></a>
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="true">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EGL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of ECG Data: Safety-Evaluable Patients</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="egl01_cache/html/setup_9ad0734898fe6fffcc3339f124b96750">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>get_param_unit_range <span class="ot">&lt;-</span> <span class="cf">function</span>(dataset) {</span>
+<span id="cb1-8"><a href="#cb1-8"></a>  u_rng <span class="ot">&lt;-</span> <span class="fu">lapply</span>(<span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD), <span class="cf">function</span>(p) {</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    dat <span class="ot">&lt;-</span> dataset <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> p)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="fu">list</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>      <span class="at">unit =</span> <span class="fu">unique</span>(dat<span class="sc">$</span>AVALU),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>      <span class="at">range =</span> <span class="fu">paste0</span>(<span class="fu">unique</span>(dat<span class="sc">$</span>ANRLO), <span class="st">"-"</span>, <span class="fu">unique</span>(dat<span class="sc">$</span>ANRHI))</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    )</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  })</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">names</span>(u_rng) <span class="ot">&lt;-</span> <span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  u_rng</span>
+<span id="cb1-17"><a href="#cb1-17"></a>}</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>eg_u_rng <span class="ot">&lt;-</span> <span class="fu">get_param_unit_range</span>(adeg)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>adeg_sub <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(EGSEQ) <span class="sc">&amp;</span> PARAMCD <span class="sc">!=</span> <span class="st">"ECGINTP"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, <span class="fu">sub</span>(<span class="st">"^.*-([[:alnum:]]+)$"</span>, <span class="st">"</span><span class="sc">\\</span><span class="st">1"</span>, SUBJID), <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">AVAL_ANRIND =</span> <span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">""</span>), AVAL, <span class="fu">paste</span>(AVAL, <span class="fu">substr</span>(ANRIND, <span class="dv">1</span>, <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">"/"</span>)),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">CHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(CHG, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>)</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  )</span>
+<span id="cb1-30"><a href="#cb1-30"></a></span>
+<span id="cb1-31"><a href="#cb1-31"></a>anl_eg <span class="ot">&lt;-</span> adeg_sub <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">select</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(AVAL_ANRIND, CHG)</span>
+<span id="cb1-37"><a href="#cb1-37"></a>  )</span>
+<span id="cb1-38"><a href="#cb1-38"></a></span>
+<span id="cb1-39"><a href="#cb1-39"></a>out <span class="ot">&lt;-</span> anl_eg <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">select</span>(CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_HR, CHG_HR, AVAL_ANRIND_QT, CHG_QT, AVAL_ANRIND_RR, CHG_RR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">AVAL_ANRIND_HR =</span> <span class="fu">paste0</span>(<span class="st">"Heart Rate Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>HR<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>HR<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">CHG_HR =</span> <span class="st">"Heart Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">AVAL_ANRIND_QT =</span> <span class="fu">paste0</span>(<span class="st">"QT Duration Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>QT<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>QT<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">CHG_QT =</span> <span class="st">"QT Duration</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    <span class="at">AVAL_ANRIND_RR =</span> <span class="fu">paste0</span>(<span class="st">"RR Duration Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>RR<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>RR<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">CHG_RR =</span> <span class="st">"RR Duration</span><span class="sc">\n</span><span class="st">Change from BL"</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="egl01_cache/html/lsting_85cd5af40355717a3b764df1f4957a6f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVISIT"</span>, <span class="st">"ADY"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of ECG Data: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">  outside the Roche standard reference range."</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of ECG Data: Safety-Evaluable Patients
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                              Heart Rate Result                    QT Duration Result                    RR Duration Result                 
+                                                                                      Study     (beats/min);        Heart Rate          (msec);          QT Duration          (msec);          RR Duration  
+Center/Subject ID            Age/Sex/Race              Treatment          Visit        Day     Range:(40-100)     Change from BL    Range:(200-500)     Change from BL    Range:(600-1500)    Change from BL
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+    BRA-1/105       38/M/BLACK OR AFRICAN AMERICAN     A: Drug X        BASELINE       149          66.94               NA               441.78               NA               896.59               NA      
+                                                                      WEEK 1 DAY 8     314          63.18             -3.76              365.68             -76.10            1376.26             479.67    
+                                                                      WEEK 2 DAY 15    398          57.57             -9.37              355.48             -86.29             799.57             -97.02    
+                                                                      WEEK 3 DAY 22    470          73.36              6.42              352.45             -89.33            1015.00             118.41    
+                                                                      WEEK 4 DAY 29    528          53.72             -13.22             388.42             -53.36            1189.29             292.70    
+                                                                      WEEK 5 DAY 36    535          58.25             -8.69              291.77            -150.01             936.09             39.50     
+    BRA-1/134                 47/M/WHITE               A: Drug X        BASELINE       227          46.99               NA               385.29               NA               835.17               NA      
+                                                                      WEEK 1 DAY 8     255          48.38              1.39              453.74             68.46              901.86             66.68     
+                                                                      WEEK 2 DAY 15    269         35.40/L            -11.59             413.54             28.26              892.01             56.84     
+                                                                      WEEK 3 DAY 22    357          60.50             13.51              394.23              8.95             490.18/L           -344.99    
+                                                                      WEEK 4 DAY 29    436          82.28             35.29              398.29             13.00              757.96             -77.21    
+                                                                      WEEK 5 DAY 36    440         38.89/L            -8.10              339.38             -45.91             880.26             45.08     
+    BRA-1/141                 35/F/WHITE             C: Combination     BASELINE       52           92.83               NA               302.14               NA              1436.04               NA      
+                                                                      WEEK 1 DAY 8     189          67.20             -25.63            197.02/L           -105.11             988.48            -447.56    
+                                                                      WEEK 2 DAY 15    262          71.22             -21.60             255.81             -46.33            1494.56             58.52     
+                                                                      WEEK 3 DAY 22    386          71.39             -21.44             245.22             -56.92            1193.28            -242.76    
+                                                                      WEEK 4 DAY 29    425          69.49             -23.34             369.92             67.78              976.32            -459.72    
+                                                                      WEEK 5 DAY 36    730          81.26             -11.56            199.68/L           -102.45             779.76            -656.28    
+    BRA-1/236       32/M/BLACK OR AFRICAN AMERICAN     B: Placebo       BASELINE       275          88.84               NA               418.61               NA             1608.46/H              NA      
+                                                                      WEEK 1 DAY 8     431         34.23/L            -54.61             449.83             31.21             1148.53            -459.93    
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if
+  outside the Roche standard reference range.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egl01_cache/html/sessioninfo_68a9ae35a760d71c96d554479fad635a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egl01_cache/html/snapshot_48825f08057c6b56aa4a54b371b1735b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/ECG/egl01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/disposition/dsl02.html" class="pagination-link">
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+  <div class="nav-page nav-page-next">
+      <a href="../../listings/efficacy/oncl01.html" class="pagination-link">
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> EGL01</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> 'Listing of ECG Data: Safety-Evaluable Patients'</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>get_param_unit_range <span class="ot">&lt;-</span> <span class="cf">function</span>(dataset) {</span>
+<span id="cb7-23"><a href="#cb7-23"></a>  u_rng <span class="ot">&lt;-</span> <span class="fu">lapply</span>(<span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD), <span class="cf">function</span>(p) {</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    dat <span class="ot">&lt;-</span> dataset <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> p)</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="fu">list</span>(</span>
+<span id="cb7-26"><a href="#cb7-26"></a>      <span class="at">unit =</span> <span class="fu">unique</span>(dat<span class="sc">$</span>AVALU),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>      <span class="at">range =</span> <span class="fu">paste0</span>(<span class="fu">unique</span>(dat<span class="sc">$</span>ANRLO), <span class="st">"-"</span>, <span class="fu">unique</span>(dat<span class="sc">$</span>ANRHI))</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    )</span>
+<span id="cb7-29"><a href="#cb7-29"></a>  })</span>
+<span id="cb7-30"><a href="#cb7-30"></a>  <span class="fu">names</span>(u_rng) <span class="ot">&lt;-</span> <span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD)</span>
+<span id="cb7-31"><a href="#cb7-31"></a>  u_rng</span>
+<span id="cb7-32"><a href="#cb7-32"></a>}</span>
+<span id="cb7-33"><a href="#cb7-33"></a></span>
+<span id="cb7-34"><a href="#cb7-34"></a>eg_u_rng <span class="ot">&lt;-</span> <span class="fu">get_param_unit_range</span>(adeg)</span>
+<span id="cb7-35"><a href="#cb7-35"></a></span>
+<span id="cb7-36"><a href="#cb7-36"></a>adeg_sub <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(EGSEQ) <span class="sc">&amp;</span> PARAMCD <span class="sc">!=</span> <span class="st">"ECGINTP"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-38"><a href="#cb7-38"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, <span class="fu">sub</span>(<span class="st">"^.*-([[:alnum:]]+)$"</span>, <span class="st">"</span><span class="sc">\\</span><span class="st">1"</span>, SUBJID), <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-41"><a href="#cb7-41"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>),</span>
+<span id="cb7-42"><a href="#cb7-42"></a>    <span class="at">AVAL_ANRIND =</span> <span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">""</span>), AVAL, <span class="fu">paste</span>(AVAL, <span class="fu">substr</span>(ANRIND, <span class="dv">1</span>, <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">"/"</span>)),</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="at">CHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(CHG, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>)</span>
+<span id="cb7-44"><a href="#cb7-44"></a>  )</span>
+<span id="cb7-45"><a href="#cb7-45"></a></span>
+<span id="cb7-46"><a href="#cb7-46"></a>anl_eg <span class="ot">&lt;-</span> adeg_sub <span class="sc">%&gt;%</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>  <span class="fu">select</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) <span class="sc">%&gt;%</span></span>
+<span id="cb7-48"><a href="#cb7-48"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-49"><a href="#cb7-49"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),</span>
+<span id="cb7-50"><a href="#cb7-50"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb7-51"><a href="#cb7-51"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(AVAL_ANRIND, CHG)</span>
+<span id="cb7-52"><a href="#cb7-52"></a>  )</span>
+<span id="cb7-53"><a href="#cb7-53"></a></span>
+<span id="cb7-54"><a href="#cb7-54"></a>out <span class="ot">&lt;-</span> anl_eg <span class="sc">%&gt;%</span></span>
+<span id="cb7-55"><a href="#cb7-55"></a>  <span class="fu">select</span>(CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_HR, CHG_HR, AVAL_ANRIND_QT, CHG_QT, AVAL_ANRIND_RR, CHG_RR) <span class="sc">%&gt;%</span></span>
+<span id="cb7-56"><a href="#cb7-56"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb7-57"><a href="#cb7-57"></a>    <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb7-58"><a href="#cb7-58"></a>    <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb7-59"><a href="#cb7-59"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-60"><a href="#cb7-60"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb7-61"><a href="#cb7-61"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb7-62"><a href="#cb7-62"></a>    <span class="at">AVAL_ANRIND_HR =</span> <span class="fu">paste0</span>(<span class="st">"Heart Rate Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>HR<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>HR<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-63"><a href="#cb7-63"></a>    <span class="at">CHG_HR =</span> <span class="st">"Heart Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-64"><a href="#cb7-64"></a>    <span class="at">AVAL_ANRIND_QT =</span> <span class="fu">paste0</span>(<span class="st">"QT Duration Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>QT<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>QT<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-65"><a href="#cb7-65"></a>    <span class="at">CHG_QT =</span> <span class="st">"QT Duration</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-66"><a href="#cb7-66"></a>    <span class="at">AVAL_ANRIND_RR =</span> <span class="fu">paste0</span>(<span class="st">"RR Duration Result</span><span class="sc">\n</span><span class="st">("</span>, eg_u_rng<span class="sc">$</span>RR<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, eg_u_rng<span class="sc">$</span>RR<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-67"><a href="#cb7-67"></a>    <span class="at">CHG_RR =</span> <span class="st">"RR Duration</span><span class="sc">\n</span><span class="st">Change from BL"</span></span>
+<span id="cb7-68"><a href="#cb7-68"></a>  )</span>
+<span id="cb7-69"><a href="#cb7-69"></a><span class="in">```</span></span>
+<span id="cb7-70"><a href="#cb7-70"></a></span>
+<span id="cb7-71"><a href="#cb7-71"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-72"><a href="#cb7-72"></a></span>
+<span id="cb7-73"><a href="#cb7-73"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-74"><a href="#cb7-74"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-75"><a href="#cb7-75"></a>  out,</span>
+<span id="cb7-76"><a href="#cb7-76"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVISIT"</span>, <span class="st">"ADY"</span>),</span>
+<span id="cb7-77"><a href="#cb7-77"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-78"><a href="#cb7-78"></a>  <span class="at">main_title =</span> <span class="st">"Listing of ECG Data: Safety-Evaluable Patients"</span>,</span>
+<span id="cb7-79"><a href="#cb7-79"></a>  <span class="at">main_footer =</span> <span class="st">"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if</span></span>
+<span id="cb7-80"><a href="#cb7-80"></a><span class="st">  outside the Roche standard reference range."</span></span>
+<span id="cb7-81"><a href="#cb7-81"></a>)</span>
+<span id="cb7-82"><a href="#cb7-82"></a></span>
+<span id="cb7-83"><a href="#cb7-83"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-84"><a href="#cb7-84"></a><span class="in">```</span></span>
+<span id="cb7-85"><a href="#cb7-85"></a></span>
+<span id="cb7-86"><a href="#cb7-86"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-87"><a href="#cb7-87"></a></span>
+<span id="cb7-88"><a href="#cb7-88"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-89"><a href="#cb7-89"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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\ No newline at end of file
diff --git a/stable/listings/adverse-events/ael01.html b/stable/listings/adverse-events/ael01.html
new file mode 100644
index 0000000000..25d8c2cea7
--- /dev/null
+++ b/stable/listings/adverse-events/ael01.html
@@ -0,0 +1,2037 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AEL01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+  "notice_banner_reject_button_hide":false,
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+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
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+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
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+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/adverse-events/ael01.html">Adverse Events</a></li><li class="breadcrumb-item"><a href="../../listings/adverse-events/ael01.html">AEL01</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael01_cache/html/setup_e1162b24ad039bbf626f45fa0765459f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">select</span>(AESOC, AEDECOD, AELLT, AETERM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">AESOC =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">AELLT =</span> <span class="st">"MedDRA Lowest Level Term"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">AETERM =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Adverse Event Term"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael01_cache/html/lsting_db3f1646d2c9519db962abbab8ab1a06">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"AESOC"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"AELLT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms
+
+—————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                               Investigator-Specified
+MedDRA System Organ Class   MedDRA Preferred Term   MedDRA Lowest Level Term     Adverse Event Term  
+—————————————————————————————————————————————————————————————————————————————————————————————————————
+          cl A                  dcd A.1.1.1.1            llt A.1.1.1.1             trm A.1.1.1.1     
+                                dcd A.1.1.1.2            llt A.1.1.1.2             trm A.1.1.1.2     
+          cl B                  dcd B.1.1.1.1            llt B.1.1.1.1             trm B.1.1.1.1     
+                                dcd B.2.1.2.1            llt B.2.1.2.1             trm B.2.1.2.1     
+                                dcd B.2.2.3.1            llt B.2.2.3.1             trm B.2.2.3.1     
+          cl C                  dcd C.1.1.1.3            llt C.1.1.1.3             trm C.1.1.1.3     
+                                dcd C.2.1.2.1            llt C.2.1.2.1             trm C.2.1.2.1     
+          cl D                  dcd D.1.1.1.1            llt D.1.1.1.1             trm D.1.1.1.1     
+                                dcd D.1.1.4.2            llt D.1.1.4.2             trm D.1.1.4.2     
+                                dcd D.2.1.5.3            llt D.2.1.5.3             trm D.2.1.5.3     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael01_cache/html/sessioninfo_edc243003449a7e576ef513007c4e1b6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael01_cache/html/snapshot_ced775f2d816240942e50dcfacf540b6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
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+    } else {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/ADA/adal02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ADAL02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/adverse-events/ael01_nollt.html" class="pagination-link">
+        <span class="nav-page-text">AEL01_NOLLT</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> AEL01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">select</span>(AESOC, AEDECOD, AELLT, AETERM) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">unique</span>()</span>
+<span id="cb9-25"><a href="#cb9-25"></a></span>
+<span id="cb9-26"><a href="#cb9-26"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>  <span class="at">AESOC =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span>,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">AELLT =</span> <span class="st">"MedDRA Lowest Level Term"</span>,</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="at">AETERM =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Adverse Event Term"</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>)</span>
+<span id="cb9-32"><a href="#cb9-32"></a><span class="in">```</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a></span>
+<span id="cb9-34"><a href="#cb9-34"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a></span>
+<span id="cb9-36"><a href="#cb9-36"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  out,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"AESOC"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"AELLT"</span>),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms"</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a>)</span>
+<span id="cb9-43"><a href="#cb9-43"></a></span>
+<span id="cb9-44"><a href="#cb9-44"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-45"><a href="#cb9-45"></a><span class="in">```</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a></span>
+<span id="cb9-47"><a href="#cb9-47"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-50"><a href="#cb9-50"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/adverse-events/ael01_nollt.html b/stable/listings/adverse-events/ael01_nollt.html
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@@ -0,0 +1,2035 @@
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+ <span class="menu-text">ADAT04B</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL01_NOLLT</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Preferred Terms and Investigator-Specified Adverse Event Terms</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael01_nollt_cache/html/setup_1ea379a2248ed228c431e0f9494b582b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">select</span>(AESOC, AEDECOD, AETERM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">AESOC =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">AETERM =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Adverse Event Term"</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael01_nollt_cache/html/lsting_9f1c612e672736eab55e223580ae5703">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"AESOC"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Preferred Terms and Investigator-Specified Adverse Event Terms"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Preferred Terms and Investigator-Specified Adverse Event Terms
+
+——————————————————————————————————————————————————————————————————————————
+                                                    Investigator-Specified
+MedDRA System Organ Class   MedDRA Preferred Term     Adverse Event Term  
+——————————————————————————————————————————————————————————————————————————
+          cl A                  dcd A.1.1.1.1           trm A.1.1.1.1     
+                                dcd A.1.1.1.2           trm A.1.1.1.2     
+          cl B                  dcd B.1.1.1.1           trm B.1.1.1.1     
+                                dcd B.2.1.2.1           trm B.2.1.2.1     
+                                dcd B.2.2.3.1           trm B.2.2.3.1     
+          cl C                  dcd C.1.1.1.3           trm C.1.1.1.3     
+                                dcd C.2.1.2.1           trm C.2.1.2.1     
+          cl D                  dcd D.1.1.1.1           trm D.1.1.1.1     
+                                dcd D.1.1.4.2           trm D.1.1.4.2     
+                                dcd D.2.1.5.3           trm D.2.1.5.3     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael01_nollt_cache/html/sessioninfo_6bd27d217564bd56c4ffc219fe8124ed">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael01_nollt_cache/html/snapshot_8d5e3f583fc0f40266503681808c9601">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/adverse-events/ael01_nollt.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/adverse-events/ael01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AEL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/adverse-events/ael02.html" class="pagination-link">
+        <span class="nav-page-text">AEL02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> AEL01_NOLLT</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Preferred Terms and Investigator-Specified Adverse Event Terms</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">select</span>(AESOC, AEDECOD, AETERM) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">unique</span>()</span>
+<span id="cb9-25"><a href="#cb9-25"></a></span>
+<span id="cb9-26"><a href="#cb9-26"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>  <span class="at">AESOC =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span>,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">AETERM =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Adverse Event Term"</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>)</span>
+<span id="cb9-31"><a href="#cb9-31"></a><span class="in">```</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a></span>
+<span id="cb9-33"><a href="#cb9-33"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-34"><a href="#cb9-34"></a></span>
+<span id="cb9-35"><a href="#cb9-35"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  out,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"AESOC"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Preferred Terms and Investigator-Specified Adverse Event Terms"</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>)</span>
+<span id="cb9-42"><a href="#cb9-42"></a></span>
+<span id="cb9-43"><a href="#cb9-43"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-44"><a href="#cb9-44"></a><span class="in">```</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a></span>
+<span id="cb9-46"><a href="#cb9-46"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-47"><a href="#cb9-47"></a></span>
+<span id="cb9-48"><a href="#cb9-48"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-49"><a href="#cb9-49"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/listings/adverse-events/ael02.html b/stable/listings/adverse-events/ael02.html
new file mode 100644
index 0000000000..5a5055059d
--- /dev/null
+++ b/stable/listings/adverse-events/ael02.html
@@ -0,0 +1,2135 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AEL02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
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+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
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+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Adverse Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael02_cache/html/setup_f39803d0772d0c9f80a6614f0fef72fc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">Date_First =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">Duration =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">Serious =</span> <span class="fu">ifelse</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AESER <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">Related =</span> <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">Outcome =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">Treated =</span> <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">Action =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>    )</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">select</span>(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, Serious, AESEV, Related, Outcome, Treated, Action)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="at">AEDECOD =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  <span class="at">Date_First =</span> <span class="st">"Date of</span><span class="sc">\n</span><span class="st">First Study</span><span class="sc">\n</span><span class="st">Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="at">ASTDY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="at">Duration =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="at">Serious =</span> <span class="st">"Serious"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="at">AESEV =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="at">Related =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="at">Outcome =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="at">Treated =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="at">Action =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael02_cache/html/lsting_f9c552f298653e1d33c48d54ec033b4e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Adverse Events"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">    recovering/resolving; 6 = unknown.</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Adverse Events
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                          Date of                                                                                         
+                                                                         Adverse        First Study     Study       AE                  Most      Caused by                         Action
+                                                                       Event MedDRA         Drug        Day of   Duration              Extreme      Study     Outcome   Treatment   Taken 
+Center/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Administration   Onset    in Days    Serious   Intensity     Drug        (1)      for AE      (2)  
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd B.2.1.2.1      04NOV2020       162       173        No      MODERATE       No          5         Yes        2   
+                                                                      dcd D.1.1.4.2      04NOV2020       196       166        No      MODERATE       No          5         No         2   
+                                                                      dcd A.1.1.1.2      04NOV2020       321       149        Yes     MODERATE       No          5         Yes        2   
+                                                                      dcd A.1.1.1.2      04NOV2020       393        43        Yes     MODERATE       No          5         No         5   
+  BRA-1/id-141                35/F/WHITE             C: Combination   dcd B.2.1.2.1      25JUL2020       387        11        No      MODERATE       No          3         Yes        1   
+                                                                      dcd D.2.1.5.3      25JUL2020       455       628        No        MILD         Yes         3         No         1   
+                                                                      dcd A.1.1.1.1      25JUL2020       739        36        No        MILD         No          4         Yes        3   
+                                                                      dcd A.1.1.1.2      25JUL2020       899       139        Yes     MODERATE       No          4         Yes        2   
+                                                                      dcd A.1.1.1.1      25JUL2020       951        66        No        MILD         No          5         No         1   
+                                                                      dcd D.1.1.1.1      25JUL2020       1093       3         Yes      SEVERE        Yes         1         No         6   
+  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JAN2021        33       614        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd B.1.1.1.1      15JAN2021       271       775        Yes      SEVERE        Yes         1         Yes        6   
+                                                                      dcd B.1.1.1.1      15JAN2021       1051       7         Yes      SEVERE        Yes         1         Yes        6   
+  BRA-1/id-265                25/M/WHITE             C: Combination   dcd C.2.1.2.1      07OCT2019        84        78        No      MODERATE       Yes         2         Yes        5   
+                                                                      dcd D.1.1.4.2      07OCT2019       349       285        No      MODERATE       No          3         Yes        7   
+                                                                      dcd D.1.1.1.1      07OCT2019       685        37        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd C.1.1.1.3      07OCT2019       705        66        No       SEVERE        Yes         4         Yes        7   
+   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd C.2.1.2.1      01JAN2020        39       506        No      MODERATE       Yes         2         No         6   
+                                                                      dcd D.1.1.1.1      01JAN2020        64       630        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd C.2.1.2.1      01JAN2020        95       306        No      MODERATE       Yes         5         No         2   
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =
+    recovering/resolving; 6 = unknown.
+(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug
+    withdrawn; 6 = not applicable; 7 = unknown.
+*  Study day derived from imputed onset date.
+** Duration derived from imputed onset date and/or end date.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael02_cache/html/sessioninfo_847fb4419b44f09aa2fcff2aaf207eea">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael02_cache/html/snapshot_b82be46d4b58a9b71373a2dd5f404feb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/adverse-events/ael02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
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+      bodyEl.classList.remove("quarto-light");
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+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
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+    const els = window.document.querySelectorAll(selector);
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+        el.classList.add('notransition');
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
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+          toggle.classList.remove("alternate");
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+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
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+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
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+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
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+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
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+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
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+  // Ensure there is a toggle, if there isn't float one in the top right
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+    a.href = "";
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
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+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
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+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
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+      button.setAttribute("data-bs-toggle", "tooltip");
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+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
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+      if (tooltip) {
+        tooltip.hide();
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+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
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+        } else {
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+        } 
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+    const config = {
+      allowHTML: true,
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+      delay: 100,
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+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
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+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+            height = bottom - top;
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
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+              parent.appendChild(div);
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+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
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+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/adverse-events/ael01_nollt.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AEL01_NOLLT</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/adverse-events/ael02_ed.html" class="pagination-link">
+        <span class="nav-page-text">AEL02_ED</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> AEL02</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Adverse Events</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">Date_First =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>    <span class="at">Duration =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    <span class="at">Serious =</span> <span class="fu">ifelse</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AESER <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb7-29"><a href="#cb7-29"></a>    <span class="at">Related =</span> <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb7-30"><a href="#cb7-30"></a>    <span class="at">Outcome =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-31"><a href="#cb7-31"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-32"><a href="#cb7-32"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-34"><a href="#cb7-34"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-35"><a href="#cb7-35"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-36"><a href="#cb7-36"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>    ),</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="at">Treated =</span> <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">Action =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-40"><a href="#cb7-40"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-41"><a href="#cb7-41"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-42"><a href="#cb7-42"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-43"><a href="#cb7-43"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-44"><a href="#cb7-44"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-45"><a href="#cb7-45"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb7-46"><a href="#cb7-46"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>    )</span>
+<span id="cb7-48"><a href="#cb7-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-49"><a href="#cb7-49"></a>  <span class="fu">select</span>(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, Serious, AESEV, Related, Outcome, Treated, Action)</span>
+<span id="cb7-50"><a href="#cb7-50"></a></span>
+<span id="cb7-51"><a href="#cb7-51"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb7-52"><a href="#cb7-52"></a>  <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-53"><a href="#cb7-53"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb7-54"><a href="#cb7-54"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-55"><a href="#cb7-55"></a>  <span class="at">AEDECOD =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb7-56"><a href="#cb7-56"></a>  <span class="at">Date_First =</span> <span class="st">"Date of</span><span class="sc">\n</span><span class="st">First Study</span><span class="sc">\n</span><span class="st">Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb7-57"><a href="#cb7-57"></a>  <span class="at">ASTDY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb7-58"><a href="#cb7-58"></a>  <span class="at">Duration =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb7-59"><a href="#cb7-59"></a>  <span class="at">Serious =</span> <span class="st">"Serious"</span>,</span>
+<span id="cb7-60"><a href="#cb7-60"></a>  <span class="at">AESEV =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb7-61"><a href="#cb7-61"></a>  <span class="at">Related =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb7-62"><a href="#cb7-62"></a>  <span class="at">Outcome =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb7-63"><a href="#cb7-63"></a>  <span class="at">Treated =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb7-64"><a href="#cb7-64"></a>  <span class="at">Action =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span></span>
+<span id="cb7-65"><a href="#cb7-65"></a>)</span>
+<span id="cb7-66"><a href="#cb7-66"></a><span class="in">```</span></span>
+<span id="cb7-67"><a href="#cb7-67"></a></span>
+<span id="cb7-68"><a href="#cb7-68"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-69"><a href="#cb7-69"></a></span>
+<span id="cb7-70"><a href="#cb7-70"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-71"><a href="#cb7-71"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-72"><a href="#cb7-72"></a>  out,</span>
+<span id="cb7-73"><a href="#cb7-73"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-74"><a href="#cb7-74"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-75"><a href="#cb7-75"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Adverse Events"</span>,</span>
+<span id="cb7-76"><a href="#cb7-76"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =</span></span>
+<span id="cb7-77"><a href="#cb7-77"></a><span class="st">    recovering/resolving; 6 = unknown.</span></span>
+<span id="cb7-78"><a href="#cb7-78"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb7-79"><a href="#cb7-79"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb7-80"><a href="#cb7-80"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb7-81"><a href="#cb7-81"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb7-82"><a href="#cb7-82"></a>)</span>
+<span id="cb7-83"><a href="#cb7-83"></a></span>
+<span id="cb7-84"><a href="#cb7-84"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-85"><a href="#cb7-85"></a><span class="in">```</span></span>
+<span id="cb7-86"><a href="#cb7-86"></a></span>
+<span id="cb7-87"><a href="#cb7-87"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-88"><a href="#cb7-88"></a></span>
+<span id="cb7-89"><a href="#cb7-89"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-90"><a href="#cb7-90"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/adverse-events/ael02_ed.html b/stable/listings/adverse-events/ael02_ed.html
new file mode 100644
index 0000000000..83d6db09a5
--- /dev/null
+++ b/stable/listings/adverse-events/ael02_ed.html
@@ -0,0 +1,2171 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AEL02_ED</title>
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+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
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+  vertical-align: middle;
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+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Listings</span></a>
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL02_ED</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Adverse Events (for Early Development Studies)</p>
+</div>
+
+
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+<div class="quarto-title-meta">
+
+    
+  
+    
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+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael02_ed_cache/html/setup_b88e5c9bfd7b10bfa76f03ad8f658748">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(lubridate)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adae_anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">DHM =</span> <span class="fu">as.period</span>(LDOSEDTM <span class="sc">%--%</span> ASTDTM),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">TMOM =</span> <span class="fu">minute</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(<span class="fu">second</span>(DHM) <span class="sc">&gt;=</span> <span class="dv">30</span>, <span class="dv">1</span>, <span class="dv">0</span>),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">TMOH =</span> <span class="fu">hour</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(TMOM <span class="sc">==</span> <span class="dv">60</span>, <span class="dv">1</span>, <span class="dv">0</span>),</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">TMOD =</span> <span class="fu">day</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(TMOH <span class="sc">==</span> <span class="dv">24</span>, <span class="dv">1</span>, <span class="dv">0</span>)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">TMOM =</span> TMOM <span class="sc">%%</span> <span class="dv">60</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">TMOH =</span> TMOH <span class="sc">%%</span> <span class="dv">24</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  )</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>out <span class="ot">&lt;-</span> adae_anl <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">ADURN =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">cent_subj =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AESER_F =</span> <span class="fu">if_else</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">AEREL_F =</span> <span class="fu">if_else</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">AECONTRT_F =</span> <span class="fu">if_else</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">AEOUT_F =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>    ),</span>
+<span id="cb1-37"><a href="#cb1-37"></a>    <span class="at">AEACN_F =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>    )</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">select</span>(</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    cent_subj, ASR, TRT01A, AEDECOD, ASTDY, TMOD, TMOH, TMOM,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    ADURN, AESER_F, AESEV, AEREL_F, AEOUT_F, AECONTRT_F, AEACN_F</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  )</span>
+<span id="cb1-51"><a href="#cb1-51"></a></span>
+<span id="cb1-52"><a href="#cb1-52"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb1-53"><a href="#cb1-53"></a>  <span class="at">cent_subj  =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>  <span class="at">ASR        =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>  <span class="at">TRT01A     =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>  <span class="at">AEDECOD    =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="at">ASTDY      =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb1-58"><a href="#cb1-58"></a>  <span class="at">TMOD       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">days"</span>,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>  <span class="at">TMOH       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">hrs"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>  <span class="at">TMOM       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">mins"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>  <span class="at">ADURN      =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>  <span class="at">AESER_F    =</span> <span class="st">"Serious"</span>,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>  <span class="at">AESEV      =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb1-64"><a href="#cb1-64"></a>  <span class="at">AEREL_F    =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>  <span class="at">AEOUT_F    =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>  <span class="at">AECONTRT_F =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb1-67"><a href="#cb1-67"></a>  <span class="at">AEACN_F    =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span></span>
+<span id="cb1-68"><a href="#cb1-68"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael02_ed_cache/html/lsting_6f1532c155a5d5cd6c202ee1d938424b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"cent_subj"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Adverse Events (for early development studies)"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">    recovering/resolving; 6 = unknown.</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Adverse Events (for early development studies)
+
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                Time from   Time from   Time from                                                                            
+                                                                         Adverse       Study    Last Dose   Last Dose   Last Dose      AE                  Most      Caused by                         Action
+                                                                       Event MedDRA    Day of   to Onset    to Onset    to Onset    Duration              Extreme      Study     Outcome   Treatment   Taken 
+Center/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Onset      days         hrs        mins      in Days    Serious   Intensity     Drug        (1)      for AE      (2)  
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd B.2.1.2.1     162         7          19           4         173        No      MODERATE       No          5         Yes        2   
+                                                                      dcd D.1.1.4.2     196         1          20          48         166        No      MODERATE       No          5         No         2   
+                                                                      dcd A.1.1.1.2     321        28          12          54         149        Yes     MODERATE       No          5         Yes        2   
+                                                                      dcd A.1.1.1.2     393        12          19          17          43        Yes     MODERATE       No          5         No         5   
+  BRA-1/id-141                35/F/WHITE             C: Combination   dcd B.2.1.2.1     387        25           8          22          11        No      MODERATE       No          3         Yes        1   
+                                                                      dcd D.2.1.5.3     455         6          16          56         628        No        MILD         Yes         3         No         1   
+                                                                      dcd A.1.1.1.1     739         0           9          38          36        No        MILD         No          4         Yes        3   
+                                                                      dcd A.1.1.1.2     899        -1          23           6         139        Yes     MODERATE       No          4         Yes        2   
+                                                                      dcd A.1.1.1.1     951         6          22          41          66        No        MILD         No          5         No         1   
+                                                                      dcd D.1.1.1.1     1093       21           5          35          3         Yes      SEVERE        Yes         1         No         6   
+  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      33        11          10          13         614        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd B.1.1.1.1     271        14           7          24         775        Yes      SEVERE        Yes         1         Yes        6   
+                                                                      dcd B.1.1.1.1     1051       26          16          28          7         Yes      SEVERE        Yes         1         Yes        6   
+  BRA-1/id-265                25/M/WHITE             C: Combination   dcd C.2.1.2.1      84        28          16          25          78        No      MODERATE       Yes         2         Yes        5   
+                                                                      dcd D.1.1.4.2     349         1           6          20         285        No      MODERATE       No          3         Yes        7   
+                                                                      dcd D.1.1.1.1     685        15           8          59          37        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd C.1.1.1.3     705        22           4          54          66        No       SEVERE        Yes         4         Yes        7   
+   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd C.2.1.2.1      39        30           9           4         506        No      MODERATE       Yes         2         No         6   
+                                                                      dcd D.1.1.1.1      64        26          17          10         630        Yes      SEVERE        Yes         1         No         6   
+                                                                      dcd C.2.1.2.1      95         4          12          58         306        No      MODERATE       Yes         5         No         2   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =
+    recovering/resolving; 6 = unknown.
+(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug
+    withdrawn; 6 = not applicable; 7 = unknown.
+*  Study day derived from imputed onset date.
+** Duration derived from imputed onset date and/or end date.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael02_ed_cache/html/sessioninfo_552261a19e5cc45d67afe5011564c46b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] lubridate_1.9.2  rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] scda_0.1.6       dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] timechange_0.2.0  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1          tidyselect_1.2.0 
+[29] utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0  
+[33] withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael02_ed_cache/html/snapshot_c4fe9207641ccce83768c21b0cd9bbac">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/adverse-events/ael02_ed.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/adverse-events/ael02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AEL02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/adverse-events/ael03.html" class="pagination-link">
+        <span class="nav-page-text">AEL03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> AEL02_ED</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Adverse Events (for Early Development Studies)</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a><span class="fu">library</span>(lubridate)</span>
+<span id="cb7-20"><a href="#cb7-20"></a></span>
+<span id="cb7-21"><a href="#cb7-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb7-22"><a href="#cb7-22"></a></span>
+<span id="cb7-23"><a href="#cb7-23"></a>adae_anl <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-25"><a href="#cb7-25"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">DHM =</span> <span class="fu">as.period</span>(LDOSEDTM <span class="sc">%--%</span> ASTDTM),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>    <span class="at">TMOM =</span> <span class="fu">minute</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(<span class="fu">second</span>(DHM) <span class="sc">&gt;=</span> <span class="dv">30</span>, <span class="dv">1</span>, <span class="dv">0</span>),</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    <span class="at">TMOH =</span> <span class="fu">hour</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(TMOM <span class="sc">==</span> <span class="dv">60</span>, <span class="dv">1</span>, <span class="dv">0</span>),</span>
+<span id="cb7-29"><a href="#cb7-29"></a>    <span class="at">TMOD =</span> <span class="fu">day</span>(DHM) <span class="sc">+</span> <span class="fu">ifelse</span>(TMOH <span class="sc">==</span> <span class="dv">24</span>, <span class="dv">1</span>, <span class="dv">0</span>)</span>
+<span id="cb7-30"><a href="#cb7-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-31"><a href="#cb7-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-32"><a href="#cb7-32"></a>    <span class="at">TMOM =</span> TMOM <span class="sc">%%</span> <span class="dv">60</span>,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>    <span class="at">TMOH =</span> TMOH <span class="sc">%%</span> <span class="dv">24</span></span>
+<span id="cb7-34"><a href="#cb7-34"></a>  )</span>
+<span id="cb7-35"><a href="#cb7-35"></a></span>
+<span id="cb7-36"><a href="#cb7-36"></a>out <span class="ot">&lt;-</span> adae_anl <span class="sc">%&gt;%</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="at">ADURN =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">cent_subj =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-41"><a href="#cb7-41"></a>    <span class="at">AESER_F =</span> <span class="fu">if_else</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb7-42"><a href="#cb7-42"></a>    <span class="at">AEREL_F =</span> <span class="fu">if_else</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="at">AECONTRT_F =</span> <span class="fu">if_else</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>, <span class="st">""</span>),</span>
+<span id="cb7-44"><a href="#cb7-44"></a>    <span class="at">AEOUT_F =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-45"><a href="#cb7-45"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-46"><a href="#cb7-46"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-47"><a href="#cb7-47"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-48"><a href="#cb7-48"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-49"><a href="#cb7-49"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-50"><a href="#cb7-50"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb7-51"><a href="#cb7-51"></a>    ),</span>
+<span id="cb7-52"><a href="#cb7-52"></a>    <span class="at">AEACN_F =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-53"><a href="#cb7-53"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-54"><a href="#cb7-54"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-55"><a href="#cb7-55"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-56"><a href="#cb7-56"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-57"><a href="#cb7-57"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-58"><a href="#cb7-58"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb7-59"><a href="#cb7-59"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb7-60"><a href="#cb7-60"></a>    )</span>
+<span id="cb7-61"><a href="#cb7-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-62"><a href="#cb7-62"></a>  <span class="fu">select</span>(</span>
+<span id="cb7-63"><a href="#cb7-63"></a>    cent_subj, ASR, TRT01A, AEDECOD, ASTDY, TMOD, TMOH, TMOM,</span>
+<span id="cb7-64"><a href="#cb7-64"></a>    ADURN, AESER_F, AESEV, AEREL_F, AEOUT_F, AECONTRT_F, AEACN_F</span>
+<span id="cb7-65"><a href="#cb7-65"></a>  )</span>
+<span id="cb7-66"><a href="#cb7-66"></a></span>
+<span id="cb7-67"><a href="#cb7-67"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb7-68"><a href="#cb7-68"></a>  <span class="at">cent_subj  =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-69"><a href="#cb7-69"></a>  <span class="at">ASR        =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb7-70"><a href="#cb7-70"></a>  <span class="at">TRT01A     =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-71"><a href="#cb7-71"></a>  <span class="at">AEDECOD    =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb7-72"><a href="#cb7-72"></a>  <span class="at">ASTDY      =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb7-73"><a href="#cb7-73"></a>  <span class="at">TMOD       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">days"</span>,</span>
+<span id="cb7-74"><a href="#cb7-74"></a>  <span class="at">TMOH       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">hrs"</span>,</span>
+<span id="cb7-75"><a href="#cb7-75"></a>  <span class="at">TMOM       =</span> <span class="st">"Time from</span><span class="sc">\n</span><span class="st">Last Dose</span><span class="sc">\n</span><span class="st">to Onset</span><span class="sc">\n</span><span class="st">mins"</span>,</span>
+<span id="cb7-76"><a href="#cb7-76"></a>  <span class="at">ADURN      =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb7-77"><a href="#cb7-77"></a>  <span class="at">AESER_F    =</span> <span class="st">"Serious"</span>,</span>
+<span id="cb7-78"><a href="#cb7-78"></a>  <span class="at">AESEV      =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb7-79"><a href="#cb7-79"></a>  <span class="at">AEREL_F    =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb7-80"><a href="#cb7-80"></a>  <span class="at">AEOUT_F    =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb7-81"><a href="#cb7-81"></a>  <span class="at">AECONTRT_F =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb7-82"><a href="#cb7-82"></a>  <span class="at">AEACN_F    =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span></span>
+<span id="cb7-83"><a href="#cb7-83"></a>)</span>
+<span id="cb7-84"><a href="#cb7-84"></a><span class="in">```</span></span>
+<span id="cb7-85"><a href="#cb7-85"></a></span>
+<span id="cb7-86"><a href="#cb7-86"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-87"><a href="#cb7-87"></a></span>
+<span id="cb7-88"><a href="#cb7-88"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-89"><a href="#cb7-89"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-90"><a href="#cb7-90"></a>  out,</span>
+<span id="cb7-91"><a href="#cb7-91"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"cent_subj"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-92"><a href="#cb7-92"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-93"><a href="#cb7-93"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Adverse Events (for early development studies)"</span>,</span>
+<span id="cb7-94"><a href="#cb7-94"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =</span></span>
+<span id="cb7-95"><a href="#cb7-95"></a><span class="st">    recovering/resolving; 6 = unknown.</span></span>
+<span id="cb7-96"><a href="#cb7-96"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb7-97"><a href="#cb7-97"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb7-98"><a href="#cb7-98"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb7-99"><a href="#cb7-99"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb7-100"><a href="#cb7-100"></a>)</span>
+<span id="cb7-101"><a href="#cb7-101"></a></span>
+<span id="cb7-102"><a href="#cb7-102"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-103"><a href="#cb7-103"></a><span class="in">```</span></span>
+<span id="cb7-104"><a href="#cb7-104"></a></span>
+<span id="cb7-105"><a href="#cb7-105"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-106"><a href="#cb7-106"></a></span>
+<span id="cb7-107"><a href="#cb7-107"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-108"><a href="#cb7-108"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/adverse-events/ael03.html b/stable/listings/adverse-events/ael03.html
new file mode 100644
index 0000000000..b759d8d483
--- /dev/null
+++ b/stable/listings/adverse-events/ael03.html
@@ -0,0 +1,2165 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
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+/* CSS for syntax highlighting */
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+.sourceCode { overflow: visible; }
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+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+ <span class="menu-text">Version</span>
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+ <span class="menu-text">ADA</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Demography</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Serious Adverse Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael03_cache/html/setup_2eb881a62b93cb3f1a9cd5c6046deb02">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">Date_First =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">Duration =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">Related =</span> <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">Outcome =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">Treated =</span> <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">Action =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>    ),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    <span class="at">SERREAS =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      AESDTH <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      AESLIFE <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      AESHOSP <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      AESDISAB <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      AESCONG <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"5"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      AESMIE <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"6"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">" "</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>    )</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="fu">select</span>(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, AESEV, Related, Outcome, Treated, Action, SERREAS)</span>
+<span id="cb1-44"><a href="#cb1-44"></a></span>
+<span id="cb1-45"><a href="#cb1-45"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="at">AEDECOD =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="at">Date_First =</span> <span class="st">"Date of</span><span class="sc">\n</span><span class="st">First Study</span><span class="sc">\n</span><span class="st">Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="at">ASTDY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="at">Duration =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>  <span class="at">AESEV =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>  <span class="at">Related =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>  <span class="at">Outcome =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>  <span class="at">Treated =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="at">Action =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span>,</span>
+<span id="cb1-58"><a href="#cb1-58"></a>  <span class="at">SERREAS =</span> <span class="st">"Reason</span><span class="sc">\n</span><span class="st">Classified</span><span class="sc">\n</span><span class="st">as Serious</span><span class="sc">\n</span><span class="st">(3)"</span></span>
+<span id="cb1-59"><a href="#cb1-59"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael03_cache/html/lsting_e3223d45edfa3faba786247eed310820">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Serious Adverse Events"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae;</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">    5 = recovering/resolving; 6 = unknown.</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="st">(3) Reason classified as serious: 1 = resulted in death; 2 = life threatening; 3 = required prolonged in patient</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a><span class="st">    hospitalization; 4 = disabling; 5 = a congenital anomaly/birth defect in offspring of study subject; 6 = does not meet any of</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a><span class="st">    the above serious criteria, but may jeopardize the subject, and may require medical or surgical intervention to prevent one of</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a><span class="st">    the outcomes listed above.</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>)</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Serious Adverse Events
+
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                          Date of                                                                                    Reason  
+                                                                         Adverse        First Study     Study       AE        Most      Caused by                         Action   Classified
+                                                                       Event MedDRA         Drug        Day of   Duration    Extreme      Study     Outcome   Treatment   Taken    as Serious
+Center/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Administration   Onset    in Days    Intensity     Drug        (1)      for AE      (2)        (3)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd A.1.1.1.2      04NOV2020       321       149      MODERATE       No          5         Yes        2          4     
+                                                                      dcd A.1.1.1.2      04NOV2020       393        43      MODERATE       No          5         No         5          5     
+  BRA-1/id-141                35/F/WHITE             C: Combination   dcd A.1.1.1.2      25JUL2020       899       139      MODERATE       No          4         Yes        2          4     
+                                                                      dcd D.1.1.1.1      25JUL2020       1093       3        SEVERE        Yes         1         No         6          1     
+  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JAN2021        33       614       SEVERE        Yes         1         No         6          1     
+                                                                      dcd B.1.1.1.1      15JAN2021       271       775       SEVERE        Yes         1         Yes        6          1     
+                                                                      dcd B.1.1.1.1      15JAN2021       1051       7        SEVERE        Yes         1         Yes        6          1     
+  BRA-1/id-265                25/M/WHITE             C: Combination   dcd D.1.1.1.1      07OCT2019       685        37       SEVERE        Yes         1         No         6          1     
+   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd D.1.1.1.1      01JAN2020        64       630       SEVERE        Yes         1         No         6          1     
+                                                                      dcd A.1.1.1.2      01JAN2020       160       259      MODERATE       No          2         Yes        2          4     
+                                                                      dcd B.2.2.3.1      01JAN2020       292        50        MILD         No          3         No         2          4     
+                                                                      dcd A.1.1.1.2      01JAN2020       459       195      MODERATE       No          5         Yes        2          5     
+                                                                      dcd B.1.1.1.1      01JAN2020       470       131       SEVERE        Yes         1         No         6          1     
+                                                                      dcd A.1.1.1.2      01JAN2020       475       113      MODERATE       No          4         Yes        2          4     
+                                                                      dcd B.1.1.1.1      01JAN2020       641        15       SEVERE        Yes         1         Yes        6          1     
+   BRA-1/id-65      25/F/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JUL2019       349       441       SEVERE        Yes         1         No         6          1     
+   BRA-1/id-93                34/F/ASIAN               A: Drug X      dcd D.1.1.1.1      20JUN2020       316       250       SEVERE        Yes         1         No         6          1     
+                                                                      dcd B.1.1.1.1      20JUN2020       523        24       SEVERE        Yes         1         No         6          1     
+                                                                      dcd B.2.2.3.1      20JUN2020       596        10        MILD         No          3         Yes        2          4     
+  BRA-11/id-321               33/F/ASIAN             C: Combination   dcd A.1.1.1.2      06OCT2020       427       335      MODERATE       No          4         No         6          2     
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae;
+    5 = recovering/resolving; 6 = unknown.
+(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug
+    withdrawn; 6 = not applicable; 7 = unknown.
+(3) Reason classified as serious: 1 = resulted in death; 2 = life threatening; 3 = required prolonged in patient
+    hospitalization; 4 = disabling; 5 = a congenital anomaly/birth defect in offspring of study subject; 6 = does not meet any of
+    the above serious criteria, but may jeopardize the subject, and may require medical or surgical intervention to prevent one of
+    the outcomes listed above.
+*  Study day derived from imputed onset date.
+** Duration derived from imputed onset date and/or end date.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael03_cache/html/sessioninfo_17461db9de0c5476abf650484c1ee76a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael03_cache/html/snapshot_910711957e1a444b0371058b66295cbe">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/adverse-events/ael03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> AEL03</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Serious Adverse Events</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>out <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>    <span class="at">Date_First =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    <span class="at">Duration =</span> AENDY <span class="sc">-</span> ASTDY <span class="sc">+</span> <span class="dv">1</span>,</span>
+<span id="cb7-29"><a href="#cb7-29"></a>    <span class="at">Related =</span> <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AEREL <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb7-30"><a href="#cb7-30"></a>    <span class="at">Outcome =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-31"><a href="#cb7-31"></a>      AEOUT <span class="sc">==</span> <span class="st">"FATAL"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-32"><a href="#cb7-32"></a>      AEOUT <span class="sc">==</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-34"><a href="#cb7-34"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-35"><a href="#cb7-35"></a>      AEOUT <span class="sc">==</span> <span class="st">"RECOVERING/RESOLVING"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-36"><a href="#cb7-36"></a>      AEOUT <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">6</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>    ),</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="at">Treated =</span> <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Yes"</span>, <span class="fu">ifelse</span>(AECONTRT <span class="sc">==</span> <span class="st">"N"</span>, <span class="st">"No"</span>, <span class="st">""</span>)),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">Action =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-40"><a href="#cb7-40"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE INCREASED"</span> <span class="sc">~</span> <span class="dv">1</span>,</span>
+<span id="cb7-41"><a href="#cb7-41"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE NOT CHANGED"</span> <span class="sc">~</span> <span class="dv">2</span>,</span>
+<span id="cb7-42"><a href="#cb7-42"></a>      AEACN <span class="sc">==</span> <span class="st">"DOSE REDUCED"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"DOSE RATE REDUCED"</span> <span class="sc">~</span> <span class="dv">3</span>,</span>
+<span id="cb7-43"><a href="#cb7-43"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG INTERRUPTED"</span> <span class="sc">~</span> <span class="dv">4</span>,</span>
+<span id="cb7-44"><a href="#cb7-44"></a>      AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span> <span class="sc">~</span> <span class="dv">5</span>,</span>
+<span id="cb7-45"><a href="#cb7-45"></a>      AEACN <span class="sc">==</span> <span class="st">"NOT APPLICABLE"</span> <span class="sc">|</span> AEACN <span class="sc">==</span> <span class="st">"NOT EVALUABLE"</span> <span class="sc">~</span> <span class="dv">6</span>,</span>
+<span id="cb7-46"><a href="#cb7-46"></a>      AEACN <span class="sc">==</span> <span class="st">"UNKNOWN"</span> <span class="sc">~</span> <span class="dv">7</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>    ),</span>
+<span id="cb7-48"><a href="#cb7-48"></a>    <span class="at">SERREAS =</span> <span class="fu">case_when</span>(</span>
+<span id="cb7-49"><a href="#cb7-49"></a>      AESDTH <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb7-50"><a href="#cb7-50"></a>      AESLIFE <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb7-51"><a href="#cb7-51"></a>      AESHOSP <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb7-52"><a href="#cb7-52"></a>      AESDISAB <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb7-53"><a href="#cb7-53"></a>      AESCONG <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"5"</span>,</span>
+<span id="cb7-54"><a href="#cb7-54"></a>      AESMIE <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"6"</span>,</span>
+<span id="cb7-55"><a href="#cb7-55"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">" "</span></span>
+<span id="cb7-56"><a href="#cb7-56"></a>    )</span>
+<span id="cb7-57"><a href="#cb7-57"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-58"><a href="#cb7-58"></a>  <span class="fu">select</span>(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, AESEV, Related, Outcome, Treated, Action, SERREAS)</span>
+<span id="cb7-59"><a href="#cb7-59"></a></span>
+<span id="cb7-60"><a href="#cb7-60"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb7-61"><a href="#cb7-61"></a>  <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-62"><a href="#cb7-62"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb7-63"><a href="#cb7-63"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-64"><a href="#cb7-64"></a>  <span class="at">AEDECOD =</span> <span class="st">"Adverse</span><span class="sc">\n</span><span class="st">Event MedDRA</span><span class="sc">\n</span><span class="st">Preferred Term"</span>,</span>
+<span id="cb7-65"><a href="#cb7-65"></a>  <span class="at">Date_First =</span> <span class="st">"Date of</span><span class="sc">\n</span><span class="st">First Study</span><span class="sc">\n</span><span class="st">Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb7-66"><a href="#cb7-66"></a>  <span class="at">ASTDY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day of</span><span class="sc">\n</span><span class="st">Onset"</span>,</span>
+<span id="cb7-67"><a href="#cb7-67"></a>  <span class="at">Duration =</span> <span class="st">"AE</span><span class="sc">\n</span><span class="st">Duration</span><span class="sc">\n</span><span class="st">in Days"</span>,</span>
+<span id="cb7-68"><a href="#cb7-68"></a>  <span class="at">AESEV =</span> <span class="st">"Most</span><span class="sc">\n</span><span class="st">Extreme</span><span class="sc">\n</span><span class="st">Intensity"</span>,</span>
+<span id="cb7-69"><a href="#cb7-69"></a>  <span class="at">Related =</span> <span class="st">"Caused by</span><span class="sc">\n</span><span class="st">Study</span><span class="sc">\n</span><span class="st">Drug"</span>,</span>
+<span id="cb7-70"><a href="#cb7-70"></a>  <span class="at">Outcome =</span> <span class="st">"Outcome</span><span class="sc">\n</span><span class="st">(1)"</span>,</span>
+<span id="cb7-71"><a href="#cb7-71"></a>  <span class="at">Treated =</span> <span class="st">"Treatment</span><span class="sc">\n</span><span class="st">for AE"</span>,</span>
+<span id="cb7-72"><a href="#cb7-72"></a>  <span class="at">Action =</span> <span class="st">"Action</span><span class="sc">\n</span><span class="st">Taken</span><span class="sc">\n</span><span class="st">(2)"</span>,</span>
+<span id="cb7-73"><a href="#cb7-73"></a>  <span class="at">SERREAS =</span> <span class="st">"Reason</span><span class="sc">\n</span><span class="st">Classified</span><span class="sc">\n</span><span class="st">as Serious</span><span class="sc">\n</span><span class="st">(3)"</span></span>
+<span id="cb7-74"><a href="#cb7-74"></a>)</span>
+<span id="cb7-75"><a href="#cb7-75"></a><span class="in">```</span></span>
+<span id="cb7-76"><a href="#cb7-76"></a></span>
+<span id="cb7-77"><a href="#cb7-77"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-78"><a href="#cb7-78"></a></span>
+<span id="cb7-79"><a href="#cb7-79"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-80"><a href="#cb7-80"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-81"><a href="#cb7-81"></a>  out,</span>
+<span id="cb7-82"><a href="#cb7-82"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-83"><a href="#cb7-83"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-84"><a href="#cb7-84"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Serious Adverse Events"</span>,</span>
+<span id="cb7-85"><a href="#cb7-85"></a>  <span class="at">main_footer =</span> <span class="st">"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae;</span></span>
+<span id="cb7-86"><a href="#cb7-86"></a><span class="st">    5 = recovering/resolving; 6 = unknown.</span></span>
+<span id="cb7-87"><a href="#cb7-87"></a><span class="st">(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug</span></span>
+<span id="cb7-88"><a href="#cb7-88"></a><span class="st">    withdrawn; 6 = not applicable; 7 = unknown.</span></span>
+<span id="cb7-89"><a href="#cb7-89"></a><span class="st">(3) Reason classified as serious: 1 = resulted in death; 2 = life threatening; 3 = required prolonged in patient</span></span>
+<span id="cb7-90"><a href="#cb7-90"></a><span class="st">    hospitalization; 4 = disabling; 5 = a congenital anomaly/birth defect in offspring of study subject; 6 = does not meet any of</span></span>
+<span id="cb7-91"><a href="#cb7-91"></a><span class="st">    the above serious criteria, but may jeopardize the subject, and may require medical or surgical intervention to prevent one of</span></span>
+<span id="cb7-92"><a href="#cb7-92"></a><span class="st">    the outcomes listed above.</span></span>
+<span id="cb7-93"><a href="#cb7-93"></a><span class="st">*  Study day derived from imputed onset date.</span></span>
+<span id="cb7-94"><a href="#cb7-94"></a><span class="st">** Duration derived from imputed onset date and/or end date."</span></span>
+<span id="cb7-95"><a href="#cb7-95"></a>)</span>
+<span id="cb7-96"><a href="#cb7-96"></a></span>
+<span id="cb7-97"><a href="#cb7-97"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-98"><a href="#cb7-98"></a><span class="in">```</span></span>
+<span id="cb7-99"><a href="#cb7-99"></a></span>
+<span id="cb7-100"><a href="#cb7-100"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-101"><a href="#cb7-101"></a></span>
+<span id="cb7-102"><a href="#cb7-102"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-103"><a href="#cb7-103"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/adverse-events/ael04.html b/stable/listings/adverse-events/ael04.html
new file mode 100644
index 0000000000..00891fd5b7
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+++ b/stable/listings/adverse-events/ael04.html
@@ -0,0 +1,2068 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+ul.task-list{list-style: none;}
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+div.sourceCode { overflow: auto; }
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+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
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+  <i class="bi"></i>
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+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
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+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+ <span class="menu-text">ADA</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AEL04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Patient Deaths</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ael04_cache/html/setup_36526772c33c1ca165a36aafd4a31de5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(DTHADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">TRTSD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>))</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">arrange</span>(SUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">select</span>(ID, AGSXRC, TRT01A, TRTSD, EOSDY, DTHADY, DTHCAUS, ADTHAUT)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">TRTSD =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">EOSDY =</span> <span class="st">"Day of Last</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">DTHADY =</span> <span class="st">"Day of</span><span class="sc">\n</span><span class="st">Death"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">DTHCAUS =</span> <span class="st">"Cause of Death"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">ADTHAUT =</span> <span class="st">"Autopsy</span><span class="sc">\n</span><span class="st">Performed?"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="ael04_cache/html/lsting_2d7edc49d454b9c640751dfd7647a9b2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="st">"ID"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patient Deaths"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Patient Deaths
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                             Date of First     Day of Last                                              
+                                                                               Study Drug       Study Drug     Day of                          Autopsy  
+Center/Patient ID               Age/Sex/Race                  Treatment      Administration   Administration   Death      Cause of Death      Performed?
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                   47/M/WHITE                   A: Drug X        04NOV2020           473          496        ADVERSE EVENT         Yes    
+  BRA-1/id-265                   25/M/WHITE                 C: Combination     07OCT2019           863          872           SUICIDE             No    
+   BRA-1/id-93                   34/F/ASIAN                   A: Drug X        20JUN2020           610          657        ADVERSE EVENT         Yes    
+  BRA-11/id-217                  43/M/ASIAN                   A: Drug X        28SEP2019           871          893        ADVERSE EVENT         Yes    
+   BRA-11/id-9                   40/M/ASIAN                 C: Combination     25MAR2019           1056         1091    DISEASE PROGRESSION      Yes    
+  BRA-14/id-120                  33/F/ASIAN                 C: Combination     19SEP2020           512          546        ADVERSE EVENT         Yes    
+  BRA-15/id-36                   38/F/ASIAN                   A: Drug X        08JAN2020           767          812     DISEASE PROGRESSION      Yes    
+  CAN-1/id-341                   43/F/ASIAN                   B: Placebo       23MAY2019           998          1013          SUICIDE            Yes    
+  CAN-11/id-139                  31/M/ASIAN                   A: Drug X        15SEP2020           519          563        ADVERSE EVENT         Yes    
+  CHN-1/id-123                   27/F/ASIAN                   A: Drug X        28JAN2020           750          750     DISEASE PROGRESSION      Yes    
+  CHN-1/id-156                   32/F/ASIAN                   B: Placebo       06SEP2020           528          542           SUICIDE             No    
+  CHN-1/id-199         27/M/BLACK OR AFRICAN AMERICAN         A: Drug X        08JAN2020           773          779     DISEASE PROGRESSION      Yes    
+  CHN-1/id-229      37/M/AMERICAN INDIAN OR ALASKA NATIVE     B: Placebo       13OCT2020           495          543     DISEASE PROGRESSION      Yes    
+  CHN-1/id-233         36/F/BLACK OR AFRICAN AMERICAN       C: Combination     11FEB2021           369          406           MISSING             NA    
+  CHN-1/id-235                   39/M/ASIAN                   A: Drug X        13JUL2019           950          968        ADVERSE EVENT         Yes    
+  CHN-1/id-307                   24/M/ASIAN                   B: Placebo       11MAR2019           1076         1121     LOST TO FOLLOW UP        NA    
+  CHN-1/id-346                   21/M/WHITE                   B: Placebo       23NOV2019           812          834        ADVERSE EVENT         Yes    
+   CHN-1/id-62                   36/F/WHITE                   A: Drug X        22NOV2020           455          497        ADVERSE EVENT         Yes    
+  CHN-10/id-380                  42/F/WHITE                   B: Placebo       09MAY2020           644          650        ADVERSE EVENT         Yes    
+  CHN-11/id-184                  38/F/ASIAN                 C: Combination     04MAY2019           1018         1029    DISEASE PROGRESSION      Yes    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ael04_cache/html/sessioninfo_3e3a296058566f5a9cee2ae45256327c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ael04_cache/html/snapshot_7086fead75e8e04d4664ba06c7f40fb7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/adverse-events/ael04.lock">Download</a></p>
+</section>
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+    if (parentEl) {
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+          el,
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+        };
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+      }
+    } else {
+      return undefined;
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    if (citeInfo) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/adverse-events/ael03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AEL03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/concomitant-medications/cml01.html" class="pagination-link">
+        <span class="nav-page-text">CML01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> AEL04</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Patient Deaths</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(DTHADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">TRTSD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>))</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="fu">arrange</span>(SUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">select</span>(ID, AGSXRC, TRT01A, TRTSD, EOSDY, DTHADY, DTHCAUS, ADTHAUT)</span>
+<span id="cb9-31"><a href="#cb9-31"></a></span>
+<span id="cb9-32"><a href="#cb9-32"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-36"><a href="#cb9-36"></a>  <span class="at">TRTSD =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  <span class="at">EOSDY =</span> <span class="st">"Day of Last</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">DTHADY =</span> <span class="st">"Day of</span><span class="sc">\n</span><span class="st">Death"</span>,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">DTHCAUS =</span> <span class="st">"Cause of Death"</span>,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">ADTHAUT =</span> <span class="st">"Autopsy</span><span class="sc">\n</span><span class="st">Performed?"</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>)</span>
+<span id="cb9-42"><a href="#cb9-42"></a><span class="in">```</span></span>
+<span id="cb9-43"><a href="#cb9-43"></a></span>
+<span id="cb9-44"><a href="#cb9-44"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a></span>
+<span id="cb9-46"><a href="#cb9-46"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-48"><a href="#cb9-48"></a>  out,</span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="at">key_cols =</span> <span class="st">"ID"</span>,</span>
+<span id="cb9-50"><a href="#cb9-50"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patient Deaths"</span></span>
+<span id="cb9-52"><a href="#cb9-52"></a>)</span>
+<span id="cb9-53"><a href="#cb9-53"></a></span>
+<span id="cb9-54"><a href="#cb9-54"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-55"><a href="#cb9-55"></a><span class="in">```</span></span>
+<span id="cb9-56"><a href="#cb9-56"></a></span>
+<span id="cb9-57"><a href="#cb9-57"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-58"><a href="#cb9-58"></a></span>
+<span id="cb9-59"><a href="#cb9-59"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-60"><a href="#cb9-60"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/concomitant-medications/cml01.html b/stable/listings/concomitant-medications/cml01.html
new file mode 100644
index 0000000000..4cfefb0d93
--- /dev/null
+++ b/stable/listings/concomitant-medications/cml01.html
@@ -0,0 +1,2090 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - CML01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../listings/concomitant-medications/cml02a_gl.html" rel="next">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+});
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+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
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+});
+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - CML01">
+<meta property="og:description" content="Listing of Previous and Concomitant Medications">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="../../index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/development" rel="" target="">
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+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/concomitant-medications/cml01.html">Concomitant Medications</a></li><li class="breadcrumb-item"><a href="../../listings/concomitant-medications/cml01.html">CML01</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CML01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Previous and Concomitant Medications</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cml01_cache/html/setup_f8024a3ca91f703cff6ba75c914741d1">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(CMDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">TRTSD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">CMASTD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ASTDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">CMSTRFL =</span> <span class="fu">ifelse</span>(ASTDY <span class="sc">&lt;</span> <span class="dv">0</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">CMENRFL =</span> <span class="fu">ifelse</span>(CMENRTPT <span class="sc">==</span> <span class="st">"ONGOING"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">select</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    ID, AGSXRC, TRT01A, CMDECOD, TRTSD, CMASTD, ASTDY, ADURN,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    CMSTRFL, CMENRFL, CMDOSE, CMDOSU, CMDOSFRQ, CMROUTE</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  )</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">CMDECOD =</span> <span class="st">"Medication Name"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">TRTSD =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">CMASTD =</span> <span class="st">"Medication</span><span class="sc">\n</span><span class="st">Start Date"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="at">ASTDY =</span> <span class="st">"Study Day"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="at">ADURN =</span> <span class="st">"Duration</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="at">CMSTRFL =</span> <span class="st">"Previous?"</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="at">CMENRFL =</span> <span class="st">"Ongoing</span><span class="sc">\n</span><span class="st">at Final</span><span class="sc">\n</span><span class="st">Contact?"</span>,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="at">CMDOSE =</span> <span class="st">"Dose"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="at">CMDOSU =</span> <span class="st">"Dose Unit"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="at">CMDOSFRQ =</span> <span class="st">"Frequency"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  <span class="at">CMROUTE =</span> <span class="st">"Route"</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="cml01_cache/html/lsting_b7ac5da5d4c39d1b587363110b66efca">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Previous and Concomitant Medications"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Previous and Concomitant Medications
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                        Date of First                                                    Ongoing                                                        
+                                                                                          Study Drug     Medication               Duration               at Final                                                       
+Center/Patient ID            Age/Sex/Race              Treatment      Medication Name   Administration   Start Date   Study Day    (days)    Previous?   Contact?   Dose   Dose Unit       Frequency           Route    
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                47/M/WHITE               A: Drug X       medname A_2/3      04NOV2020      21SEP2021       321        -148        No          No       30    mg/breath          Q4H          INTRAMUSCULAR
+                                                                                          04NOV2020      02DEC2021       393        -42         No          No       41     umol/L           TWICE            UNKNOWN   
+                                                                       medname B_1/4      04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS 
+                                                                                          04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS 
+                                                                                          04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS 
+                                                                       medname C_1/2      04NOV2020      19MAY2021       196        -165        No          No       22      ug/mL            TID             INHALED   
+                                                                                          04NOV2020      19MAY2021       196        -165        No          No       22      ug/mL            TID             INHALED   
+  BRA-1/id-141                35/F/WHITE             C: Combination    medname A_1/3      25JUL2020      03AUG2022       739        -35         No          No       84      ug/mL            QN              INHALED   
+                                                                                          25JUL2020      10JAN2023       899        -138        No          No       1       DROP      4 TIMES PER MONTH       ORAL     
+                                                                                          25JUL2020      03MAR2023       951        -65         No          No       70       uL              QN               NASAL    
+                                                                       medname A_3/3      25JUL2020      16AUG2021       387        -10         No          No       54     umol/L            QN           INTRAMUSCULAR
+                                                                                          25JUL2020      16AUG2021       387        -10         No          No       54     umol/L            QN           INTRAMUSCULAR
+                                                                       medname B_4/4      25JUL2020      23JUL2023      1093         -2         No          No       55       uL              Q4H           INTRAVENOUS 
+                                                                       medname C_2/2      25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   
+                                                                                          25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   
+                                                                                          25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   
+  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo      medname A_2/3      15JAN2021      13OCT2021       271        -774        No          No       9      umol/L     4 TIMES PER MONTH      UNKNOWN   
+                                                                       medname A_3/3      15JAN2021      17FEB2021       33         -613        No          No       30      DROP             Q4H             UNKNOWN   
+                                                                                          15JAN2021      02DEC2023      1051         -6         No          No       74    mg/breath         TWICE            INHALED   
+                                                                                          15JAN2021      17FEB2021       33         -613        No          No       30      DROP             Q4H             UNKNOWN   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cml01_cache/html/sessioninfo_2b05537c1e44f97466e23123dc0ff945">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cml01_cache/html/snapshot_fc524e07325bfea8c590664c27c172d0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/concomitant-medications/cml01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> CML01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Previous and Concomitant Medications</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(CMDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">TRTSD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">CMASTD =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ASTDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-29"><a href="#cb9-29"></a>    <span class="at">CMSTRFL =</span> <span class="fu">ifelse</span>(ASTDY <span class="sc">&lt;</span> <span class="dv">0</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>),</span>
+<span id="cb9-30"><a href="#cb9-30"></a>    <span class="at">CMENRFL =</span> <span class="fu">ifelse</span>(CMENRTPT <span class="sc">==</span> <span class="st">"ONGOING"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>)</span>
+<span id="cb9-31"><a href="#cb9-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>  <span class="fu">select</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    ID, AGSXRC, TRT01A, CMDECOD, TRTSD, CMASTD, ASTDY, ADURN,</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    CMSTRFL, CMENRFL, CMDOSE, CMDOSU, CMDOSFRQ, CMROUTE</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  )</span>
+<span id="cb9-36"><a href="#cb9-36"></a></span>
+<span id="cb9-37"><a href="#cb9-37"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">CMDECOD =</span> <span class="st">"Medication Name"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">TRTSD =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">CMASTD =</span> <span class="st">"Medication</span><span class="sc">\n</span><span class="st">Start Date"</span>,</span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="at">ASTDY =</span> <span class="st">"Study Day"</span>,</span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="at">ADURN =</span> <span class="st">"Duration</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb9-46"><a href="#cb9-46"></a>  <span class="at">CMSTRFL =</span> <span class="st">"Previous?"</span>,</span>
+<span id="cb9-47"><a href="#cb9-47"></a>  <span class="at">CMENRFL =</span> <span class="st">"Ongoing</span><span class="sc">\n</span><span class="st">at Final</span><span class="sc">\n</span><span class="st">Contact?"</span>,</span>
+<span id="cb9-48"><a href="#cb9-48"></a>  <span class="at">CMDOSE =</span> <span class="st">"Dose"</span>,</span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="at">CMDOSU =</span> <span class="st">"Dose Unit"</span>,</span>
+<span id="cb9-50"><a href="#cb9-50"></a>  <span class="at">CMDOSFRQ =</span> <span class="st">"Frequency"</span>,</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  <span class="at">CMROUTE =</span> <span class="st">"Route"</span></span>
+<span id="cb9-52"><a href="#cb9-52"></a>)</span>
+<span id="cb9-53"><a href="#cb9-53"></a><span class="in">```</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a></span>
+<span id="cb9-55"><a href="#cb9-55"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-56"><a href="#cb9-56"></a></span>
+<span id="cb9-57"><a href="#cb9-57"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-58"><a href="#cb9-58"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-59"><a href="#cb9-59"></a>  out,</span>
+<span id="cb9-60"><a href="#cb9-60"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb9-61"><a href="#cb9-61"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-62"><a href="#cb9-62"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Previous and Concomitant Medications"</span></span>
+<span id="cb9-63"><a href="#cb9-63"></a>)</span>
+<span id="cb9-64"><a href="#cb9-64"></a></span>
+<span id="cb9-65"><a href="#cb9-65"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-66"><a href="#cb9-66"></a><span class="in">```</span></span>
+<span id="cb9-67"><a href="#cb9-67"></a></span>
+<span id="cb9-68"><a href="#cb9-68"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-69"><a href="#cb9-69"></a></span>
+<span id="cb9-70"><a href="#cb9-70"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-71"><a href="#cb9-71"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/concomitant-medications/cml02a_gl.html b/stable/listings/concomitant-medications/cml02a_gl.html
new file mode 100644
index 0000000000..360e4d459f
--- /dev/null
+++ b/stable/listings/concomitant-medications/cml02a_gl.html
@@ -0,0 +1,2042 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - CML02A_GL</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
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+<meta name="quarto:offset" content="../../">
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+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+ga('create', 'UA-125641273-1', 'auto');
+
+ga('send', {
+  hitType: 'pageview',
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+});
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+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
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+});
+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - CML02A_GL">
+<meta property="og:description" content="Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="../../index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
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+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/concomitant-medications/cml01.html">Concomitant Medications</a></li><li class="breadcrumb-item"><a href="../../listings/concomitant-medications/cml02a_gl.html">CML02A_GL</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
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+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+</li>
+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CML02A_GL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cml02a_gl_cache/html/setup_77f01ca6660654bc172f106d7f34c541">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">select</span>(ATC2, CMDECOD, CMTRT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">ATC2 =</span> <span class="st">"ATC Class Level 2"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">CMDECOD =</span> <span class="st">"WHODrug Preferred Name"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">CMTRT =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Treatment Term"</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="cml02a_gl_cache/html/lsting_523be8804e99a781ccb66688b435fdc1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"CMDECOD"</span>, <span class="st">"CMTRT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms
+
+———————————————————————————————————————————————————————————————————
+                                             Investigator-Specified
+ATC Class Level 2   WHODrug Preferred Name       Treatment Term    
+———————————————————————————————————————————————————————————————————
+   ATCCLAS2 A           medname A_1/3                A_1/3         
+                        medname A_2/3                A_2/3         
+                        medname A_3/3                A_3/3         
+  ATCCLAS2 A p2         medname A_3/3                A_3/3         
+   ATCCLAS2 B           medname B_1/4                B_1/4         
+                        medname B_2/4                B_2/4         
+                        medname B_3/4                B_3/4         
+                        medname B_4/4                B_4/4         
+  ATCCLAS2 B p2         medname B_1/4                B_1/4         
+                        medname B_2/4                B_2/4         
+  ATCCLAS2 B p3         medname B_1/4                B_1/4         
+                        medname B_2/4                B_2/4         
+   ATCCLAS2 C           medname C_1/2                C_1/2         
+                        medname C_2/2                C_2/2         
+  ATCCLAS2 C p2         medname C_1/2                C_1/2         
+                        medname C_2/2                C_2/2         
+  ATCCLAS2 C p3         medname C_2/2                C_2/2         </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cml02a_gl_cache/html/sessioninfo_d21f8bf60f63ce709f16219be9d22757">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cml02a_gl_cache/html/snapshot_c334a50a90515a4a7d67cf51688d2985">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/concomitant-medications/cml02a_gl.lock">Download</a></p>
+</section>
+</div>
+</div>
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+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
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+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
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+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/concomitant-medications/cml01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CML01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/concomitant-medications/cml02b_gl.html" class="pagination-link">
+        <span class="nav-page-text">CML02B_GL</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> CML02A_GL</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">select</span>(ATC2, CMDECOD, CMTRT) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">unique</span>()</span>
+<span id="cb9-25"><a href="#cb9-25"></a></span>
+<span id="cb9-26"><a href="#cb9-26"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>  <span class="at">ATC2 =</span> <span class="st">"ATC Class Level 2"</span>,</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="at">CMDECOD =</span> <span class="st">"WHODrug Preferred Name"</span>,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">CMTRT =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Treatment Term"</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>)</span>
+<span id="cb9-31"><a href="#cb9-31"></a><span class="in">```</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a></span>
+<span id="cb9-33"><a href="#cb9-33"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-34"><a href="#cb9-34"></a></span>
+<span id="cb9-35"><a href="#cb9-35"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  out,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"CMDECOD"</span>, <span class="st">"CMTRT"</span>),</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms"</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>)</span>
+<span id="cb9-42"><a href="#cb9-42"></a></span>
+<span id="cb9-43"><a href="#cb9-43"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-44"><a href="#cb9-44"></a><span class="in">```</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a></span>
+<span id="cb9-46"><a href="#cb9-46"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-47"><a href="#cb9-47"></a></span>
+<span id="cb9-48"><a href="#cb9-48"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-49"><a href="#cb9-49"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/concomitant-medications/cml02b_gl.html b/stable/listings/concomitant-medications/cml02b_gl.html
new file mode 100644
index 0000000000..2eb41d0497
--- /dev/null
+++ b/stable/listings/concomitant-medications/cml02b_gl.html
@@ -0,0 +1,2048 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+/* CSS for syntax highlighting */
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
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+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+      </ul>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+ <span class="menu-text">DMT01</span></a>
+  </div>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+ <span class="menu-text">DISCLOSUREST01</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">Disposition</span></a>
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+<li class="sidebar-item">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CML02B_GL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cml02b_gl_cache/html/setup_d39eefa5feb1788dd4018ba455849e9e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">select</span>(ATC1, ATC2, ATC3, ATC4, CMDECOD, CMTRT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">ATC1 =</span> <span class="st">"ATC Class Level 1"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">ATC2 =</span> <span class="st">"ATC Class Level 2"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">ATC3 =</span> <span class="st">"ATC Class Level 3"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">ATC4 =</span> <span class="st">"ATC Class Level 4"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">CMDECOD =</span> <span class="st">"WHODrug Preferred Name"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">CMTRT =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Treatment Term"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="cml02b_gl_cache/html/lsting_e3997e3948587bb1de31b959c1a54e92">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>, <span class="st">"CMDECOD"</span>, <span class="st">"CMTRT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                         Investigator-Specified
+ATC Class Level 1   ATC Class Level 2   ATC Class Level 3   ATC Class Level 4   WHODrug Preferred Name       Treatment Term    
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   ATCCLAS1 A          ATCCLAS2 A          ATCCLAS3 A          ATCCLAS4 A           medname A_1/3                A_1/3         
+                                                                                    medname A_2/3                A_2/3         
+                                                                                    medname A_3/3                A_3/3         
+  ATCCLAS1 A p2       ATCCLAS2 A p2       ATCCLAS3 A p2       ATCCLAS4 A p2         medname A_3/3                A_3/3         
+   ATCCLAS1 B          ATCCLAS2 B          ATCCLAS3 B          ATCCLAS4 B           medname B_1/4                B_1/4         
+                                                                                    medname B_2/4                B_2/4         
+                                                                                    medname B_3/4                B_3/4         
+                                                                                    medname B_4/4                B_4/4         
+  ATCCLAS1 B p2       ATCCLAS2 B p2       ATCCLAS3 B p2       ATCCLAS4 B p2         medname B_1/4                B_1/4         
+                                                                                    medname B_2/4                B_2/4         
+  ATCCLAS1 B p3       ATCCLAS2 B p3       ATCCLAS3 B p3       ATCCLAS4 B p3         medname B_1/4                B_1/4         
+                                                                                    medname B_2/4                B_2/4         
+   ATCCLAS1 C          ATCCLAS2 C          ATCCLAS3 C          ATCCLAS4 C           medname C_1/2                C_1/2         
+                                                                                    medname C_2/2                C_2/2         
+  ATCCLAS1 C p2       ATCCLAS2 C p2       ATCCLAS3 C p2       ATCCLAS4 C p2         medname C_1/2                C_1/2         
+                                                                                    medname C_2/2                C_2/2         
+  ATCCLAS1 C p3       ATCCLAS2 C p3       ATCCLAS3 C p3       ATCCLAS4 C p3         medname C_2/2                C_2/2         </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cml02b_gl_cache/html/sessioninfo_fc8fdd4ba528c141f1467f2ad7f69f33">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cml02b_gl_cache/html/snapshot_eeb13c0f82baa038f1f80981f126ba6e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/concomitant-medications/cml02b_gl.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    if (citeInfo) {
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/concomitant-medications/cml02a_gl.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CML02A_GL</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/development-safety-update-report/dsur4.html" class="pagination-link">
+        <span class="nav-page-text">DSUR4</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> CML02B_GL</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">select</span>(ATC1, ATC2, ATC3, ATC4, CMDECOD, CMTRT) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">unique</span>()</span>
+<span id="cb9-25"><a href="#cb9-25"></a></span>
+<span id="cb9-26"><a href="#cb9-26"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>  <span class="at">ATC1 =</span> <span class="st">"ATC Class Level 1"</span>,</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="at">ATC2 =</span> <span class="st">"ATC Class Level 2"</span>,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">ATC3 =</span> <span class="st">"ATC Class Level 3"</span>,</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="at">ATC4 =</span> <span class="st">"ATC Class Level 4"</span>,</span>
+<span id="cb9-31"><a href="#cb9-31"></a>  <span class="at">CMDECOD =</span> <span class="st">"WHODrug Preferred Name"</span>,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>  <span class="at">CMTRT =</span> <span class="st">"Investigator-Specified</span><span class="sc">\n</span><span class="st">Treatment Term"</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a>)</span>
+<span id="cb9-34"><a href="#cb9-34"></a><span class="in">```</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a></span>
+<span id="cb9-36"><a href="#cb9-36"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a></span>
+<span id="cb9-38"><a href="#cb9-38"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-39"><a href="#cb9-39"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  out,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>, <span class="st">"CMDECOD"</span>, <span class="st">"CMTRT"</span>),</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms"</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a>)</span>
+<span id="cb9-45"><a href="#cb9-45"></a></span>
+<span id="cb9-46"><a href="#cb9-46"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-47"><a href="#cb9-47"></a><span class="in">```</span></span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-50"><a href="#cb9-50"></a></span>
+<span id="cb9-51"><a href="#cb9-51"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-52"><a href="#cb9-52"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/listings/development-safety-update-report/dsur4.html b/stable/listings/development-safety-update-report/dsur4.html
new file mode 100644
index 0000000000..ad2b94f9a0
--- /dev/null
+++ b/stable/listings/development-safety-update-report/dsur4.html
@@ -0,0 +1,2049 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
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+div.sourceCode { overflow: auto; }
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+pre > code.sourceCode { white-space: pre-wrap; }
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+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="true">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DSUR4</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Patients Who Died During Reporting Period</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dsur4_cache/html/setup_5b51bae8d31a8f3532855d5033d5edd7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(DTHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">select</span>(ARM, ID, DTHCAUS)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>death_num <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(out<span class="sc">$</span>ID))</span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">ARM =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">DTHCAUS =</span> <span class="st">"Cause of Death"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="dsur4_cache/html/lsting_bdc0624f18c3086f5be1faa39632bf43">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients Who Died During Reporting Period"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Number of patient deaths during reporting period ="</span>, death_num)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Patients Who Died During Reporting Period
+Number of patient deaths during reporting period = 70
+
+———————————————————————————————————————————————————————————————————
+Treatment Group   Center/Patient ID          Cause of Death        
+———————————————————————————————————————————————————————————————————
+   A: Drug X        CHN-3/id-128              ADVERSE EVENT        
+                     RUS-1/id-52           DISEASE PROGRESSION     
+                    CHN-1/id-235              ADVERSE EVENT        
+                    CHN-5/id-108                 MISSING           
+                    CHN-17/id-182           LOST TO FOLLOW UP      
+                    BRA-11/id-217             ADVERSE EVENT        
+                    CHN-15/id-14           DISEASE PROGRESSION     
+                    CHN-2/id-274                 SUICIDE           
+                    USA-11/id-339                UNKNOWN           
+                    BRA-15/id-36           DISEASE PROGRESSION     
+                    CHN-1/id-199           DISEASE PROGRESSION     
+                    CHN-2/id-272           DISEASE PROGRESSION     
+                    CHN-1/id-123           DISEASE PROGRESSION     
+                    CHN-12/id-258                SUICIDE           
+                    CHN-17/id-92            LOST TO FOLLOW UP      
+                     NGA-1/id-46           DISEASE PROGRESSION     
+                     BRA-1/id-93              ADVERSE EVENT        
+                     CHN-6/id-30      Post-study reporting of death
+                    CAN-11/id-139             ADVERSE EVENT        
+                    GBR-1/id-319              ADVERSE EVENT        </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dsur4_cache/html/sessioninfo_7fdf866053cad907bf800e9c4b7672dc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dsur4_cache/html/snapshot_5638209e8ea0e83dbef10c206a9ad5b6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/development-safety-update-report/dsur4.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
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+    // flash "checked"
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+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+      let selectedAnnoteEl;
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
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+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
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+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
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+          selectedAnnoteEl = annoteEl;
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+      const unselectCodeLines = () => {
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+    if (parentEl) {
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/concomitant-medications/cml02b_gl.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CML02B_GL</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/disposition/dsl01.html" class="pagination-link">
+        <span class="nav-page-text">DSL01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> DSUR4</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Patients Who Died During Reporting Period</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(DTHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a>  <span class="fu">select</span>(ARM, ID, DTHCAUS)</span>
+<span id="cb9-26"><a href="#cb9-26"></a>death_num <span class="ot">&lt;-</span> <span class="fu">length</span>(<span class="fu">unique</span>(out<span class="sc">$</span>ID))</span>
+<span id="cb9-27"><a href="#cb9-27"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="at">ARM =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="at">DTHCAUS =</span> <span class="st">"Cause of Death"</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>)</span>
+<span id="cb9-32"><a href="#cb9-32"></a><span class="in">```</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a></span>
+<span id="cb9-34"><a href="#cb9-34"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a></span>
+<span id="cb9-36"><a href="#cb9-36"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  out,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients Who Died During Reporting Period"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Number of patient deaths during reporting period ="</span>, death_num)</span>
+<span id="cb9-43"><a href="#cb9-43"></a>)</span>
+<span id="cb9-44"><a href="#cb9-44"></a></span>
+<span id="cb9-45"><a href="#cb9-45"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-46"><a href="#cb9-46"></a><span class="in">```</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a></span>
+<span id="cb9-48"><a href="#cb9-48"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-49"><a href="#cb9-49"></a></span>
+<span id="cb9-50"><a href="#cb9-50"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-51"><a href="#cb9-51"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/listings/disposition/dsl01.html b/stable/listings/disposition/dsl01.html
new file mode 100644
index 0000000000..1f18e4d7cd
--- /dev/null
+++ b/stable/listings/disposition/dsl01.html
@@ -0,0 +1,2064 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - DSL01</title>
+<style>
+code{white-space: pre-wrap;}
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+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="true">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DSL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Patients with Study Drug Withdrawn Due to Adverse Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dsl01_cache/html/setup_a0f66ae1877faadd91fb3676417f0a79">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(AEWITHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">SSADM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="at">format =</span> <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">STDWD =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(TRTEDTM, TRTSDTM, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">DISCONT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(DCSREAS) <span class="sc">&amp;</span> <span class="fu">toupper</span>(EOSSTT) <span class="sc">==</span> <span class="st">"DISCONTINUED"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, SSADM, STDWD, DISCONT)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">SSADM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">STDWD =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">of Withdrawal"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">DISCONT =</span> <span class="st">"Discontinued</span><span class="sc">\n</span><span class="st">Early from Study?"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="dsl01_cache/html/lsting_1436e860297bd9a9b04289f370371919">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients with Study Drug Withdrawn Due to Adverse Events"</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Patients with Study Drug Withdrawn Due to Adverse Events
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                      Date of First                                     
+                                                                                        Study Drug       Study Day       Discontinued   
+Center/Patient ID                    Age/Sex/Race                      Treatment      Administration   of Withdrawal   Early from Study?
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   BRA-1/id-42              36/M/BLACK OR AFRICAN AMERICAN             A: Drug X        01JAN2020           NA                No        
+  BRA-11/id-237                       64/F/ASIAN                     C: Combination     10MAR2020          1096               No        
+   CHN-1/id-26                        29/M/WHITE                       A: Drug X        16JUL2020          1096               No        
+   CHN-1/id-62                        36/F/WHITE                       A: Drug X        22NOV2020           455               Yes       
+  CHN-11/id-256                       23/M/ASIAN                       A: Drug X        17MAR2020          1096               No        
+  CHN-11/id-257                       32/F/ASIAN                     C: Combination     15NOV2020          1096               No        
+  CHN-11/id-263                       34/F/ASIAN                     C: Combination     03APR2019          1096               No        
+  CHN-11/id-349                       40/M/ASIAN                     C: Combination     13NOV2020          1096               No        
+  CHN-11/id-91              44/M/BLACK OR AFRICAN AMERICAN           C: Combination     29MAY2020           625               Yes       
+  CHN-13/id-102                       37/M/ASIAN                       B: Placebo       23MAR2019          1096               No        
+  CHN-15/id-262             35/M/BLACK OR AFRICAN AMERICAN           C: Combination     26FEB2019          1096               No        
+  CHN-17/id-31                        35/F/ASIAN                     C: Combination     17NOV2019           NA                No        
+  CHN-3/id-333              30/F/BLACK OR AFRICAN AMERICAN             B: Placebo       13JAN2020           NA                No        
+   CHN-7/id-28          40/M/AMERICAN INDIAN OR ALASKA NATIVE          B: Placebo       11MAR2019          1096               No        
+   CHN-9/id-11      28/F/NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER     B: Placebo       27JAN2021           388               Yes       
+  CHN-9/id-147                        26/F/ASIAN                       B: Placebo       06FEB2020           NA                No        
+  NGA-11/id-173             24/F/BLACK OR AFRICAN AMERICAN           C: Combination     10MAR2019          1096               No        
+  PAK-2/id-191          38/F/AMERICAN INDIAN OR ALASKA NATIVE        C: Combination     07APR2019          1096               No        
+  RUS-18/id-359             47/F/BLACK OR AFRICAN AMERICAN             A: Drug X        08JUN2019          1096               No        
+  USA-11/id-100                       40/F/ASIAN                     C: Combination     10MAR2020           705               Yes       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dsl01_cache/html/sessioninfo_0ba2da453a78dbf1162abee0252ac5fc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dsl01_cache/html/snapshot_021e96b58ddb0e2c4b4aa3776c78cc79">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/disposition/dsl01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
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+      bodyEl.classList.remove("quarto-light");
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+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
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+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
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+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
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+      return false;
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+  function toggleCodeHandler(show) {
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+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
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+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
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+      }
+      return false;
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+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
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+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
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+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
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+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
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+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/development-safety-update-report/dsur4.html" class="pagination-link">
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+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/disposition/dsl02.html" class="pagination-link">
+        <span class="nav-page-text">DSL02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> DSL01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Patients with Study Drug Withdrawn Due to Adverse Events</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(AEWITHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">SSADM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="at">format =</span> <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">STDWD =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(TRTEDTM, TRTSDTM, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb9-29"><a href="#cb9-29"></a>    <span class="at">DISCONT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(DCSREAS) <span class="sc">&amp;</span> <span class="fu">toupper</span>(EOSSTT) <span class="sc">==</span> <span class="st">"DISCONTINUED"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>)</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, SSADM, STDWD, DISCONT)</span>
+<span id="cb9-32"><a href="#cb9-32"></a></span>
+<span id="cb9-33"><a href="#cb9-33"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb9-36"><a href="#cb9-36"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  <span class="at">SSADM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">STDWD =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">of Withdrawal"</span>,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">DISCONT =</span> <span class="st">"Discontinued</span><span class="sc">\n</span><span class="st">Early from Study?"</span></span>
+<span id="cb9-40"><a href="#cb9-40"></a>)</span>
+<span id="cb9-41"><a href="#cb9-41"></a><span class="in">```</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a></span>
+<span id="cb9-43"><a href="#cb9-43"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a></span>
+<span id="cb9-45"><a href="#cb9-45"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-47"><a href="#cb9-47"></a>  out,</span>
+<span id="cb9-48"><a href="#cb9-48"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients with Study Drug Withdrawn Due to Adverse Events"</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>)</span>
+<span id="cb9-51"><a href="#cb9-51"></a></span>
+<span id="cb9-52"><a href="#cb9-52"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-53"><a href="#cb9-53"></a><span class="in">```</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a></span>
+<span id="cb9-55"><a href="#cb9-55"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-56"><a href="#cb9-56"></a></span>
+<span id="cb9-57"><a href="#cb9-57"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-58"><a href="#cb9-58"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/disposition/dsl02.html b/stable/listings/disposition/dsl02.html
new file mode 100644
index 0000000000..4b6d2109ea
--- /dev/null
+++ b/stable/listings/disposition/dsl02.html
@@ -0,0 +1,2067 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET07</span></a>
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="true">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DSL02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Patients Who Discontinued Early from Study</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dsl02_cache/html/setup_f160ba5332e8e806a435e48dcf0efe99">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(AEWITHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">DISCONT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(DCSREAS) <span class="sc">&amp;</span> EOSSTT <span class="sc">!=</span> <span class="st">"COMPLETED"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">SSADTM =</span> <span class="fu">as.POSIXct</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>      <span class="fu">strftime</span>(TRTSDTM, <span class="at">format =</span> <span class="st">"%Y-%m-%d %H:%M:%S"</span>),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      <span class="at">format =</span> <span class="st">"%Y-%m-%d"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      <span class="at">tz =</span> <span class="st">"UTC"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>    ),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">SSAEDY =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(EOSDT, SSADTM, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">RANDEDY =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(EOSDT, RANDDT, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">filter</span>(DISCONT <span class="sc">==</span> <span class="st">"Yes"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, SSADTM, EOSDY, SSAEDY, RANDEDY, DCSREAS)</span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">SSADTM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="at">EOSDY =</span> <span class="st">"Day of Last</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="at">SSAEDY =</span> <span class="st">"Day of Study</span><span class="sc">\n</span><span class="st">Discontinuation</span><span class="sc">\n</span><span class="st">Relative to First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="at">RANDEDY =</span> <span class="st">"Day of Study</span><span class="sc">\n</span><span class="st">Discontinuation</span><span class="sc">\n</span><span class="st">Relative to</span><span class="sc">\n</span><span class="st">Randomization"</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="at">DCSREAS =</span> <span class="st">"Reason for</span><span class="sc">\n</span><span class="st">Discontinuation"</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="dsl02_cache/html/lsting_d67ae4bcda3449f958d1ff922ce3ad70">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients Who Discontinued Early from Study"</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Patients Who Discontinued Early from Study
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                                          Day of Study                                        
+                                                                                                                         Discontinuation     Day of Study                     
+                                                                                      Date of First     Day of Last     Relative to First   Discontinuation                   
+                                                                                        Study Drug       Study Drug        Study Drug         Relative to        Reason for   
+Center/Patient ID                    Age/Sex/Race                      Treatment      Administration   Administration    Administration      Randomization    Discontinuation 
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   CHN-1/id-62                        36/F/WHITE                       A: Drug X        2020-11-22          455                454                455              DEATH      
+  CHN-11/id-91              44/M/BLACK OR AFRICAN AMERICAN           C: Combination     2020-05-29          625                625                626              DEATH      
+   CHN-9/id-11      28/F/NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER     B: Placebo       2021-01-27          388                387                388              DEATH      
+  USA-11/id-100                       40/F/ASIAN                     C: Combination     2020-03-10          705                705                707         LACK OF EFFICACY
+  USA-11/id-136                       38/F/ASIAN                     C: Combination     2019-10-02          865                864                868              DEATH      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dsl02_cache/html/sessioninfo_dbf6f697b12c78a17fb5db9ca35ae352">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dsl02_cache/html/snapshot_3ac1481ad96dc1203ace732f732dfd47">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/disposition/dsl02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> DSL02</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Patients Who Discontinued Early from Study</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(AEWITHFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">DISCONT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(DCSREAS) <span class="sc">&amp;</span> EOSSTT <span class="sc">!=</span> <span class="st">"COMPLETED"</span>, <span class="st">"Yes"</span>, <span class="st">"No"</span>),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">SSADTM =</span> <span class="fu">as.POSIXct</span>(</span>
+<span id="cb9-29"><a href="#cb9-29"></a>      <span class="fu">strftime</span>(TRTSDTM, <span class="at">format =</span> <span class="st">"%Y-%m-%d %H:%M:%S"</span>),</span>
+<span id="cb9-30"><a href="#cb9-30"></a>      <span class="at">format =</span> <span class="st">"%Y-%m-%d"</span>,</span>
+<span id="cb9-31"><a href="#cb9-31"></a>      <span class="at">tz =</span> <span class="st">"UTC"</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>    ),</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">SSAEDY =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(EOSDT, SSADTM, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">RANDEDY =</span> <span class="fu">as.numeric</span>(<span class="fu">ceiling</span>(<span class="fu">difftime</span>(EOSDT, RANDDT, <span class="at">units =</span> <span class="st">"days"</span>))),</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>  <span class="fu">filter</span>(DISCONT <span class="sc">==</span> <span class="st">"Yes"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, SSADTM, EOSDY, SSAEDY, RANDEDY, DCSREAS)</span>
+<span id="cb9-38"><a href="#cb9-38"></a></span>
+<span id="cb9-39"><a href="#cb9-39"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">SSADTM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="at">EOSDY =</span> <span class="st">"Day of Last</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="at">SSAEDY =</span> <span class="st">"Day of Study</span><span class="sc">\n</span><span class="st">Discontinuation</span><span class="sc">\n</span><span class="st">Relative to First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-46"><a href="#cb9-46"></a>  <span class="at">RANDEDY =</span> <span class="st">"Day of Study</span><span class="sc">\n</span><span class="st">Discontinuation</span><span class="sc">\n</span><span class="st">Relative to</span><span class="sc">\n</span><span class="st">Randomization"</span>,</span>
+<span id="cb9-47"><a href="#cb9-47"></a>  <span class="at">DCSREAS =</span> <span class="st">"Reason for</span><span class="sc">\n</span><span class="st">Discontinuation"</span></span>
+<span id="cb9-48"><a href="#cb9-48"></a>)</span>
+<span id="cb9-49"><a href="#cb9-49"></a><span class="in">```</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a></span>
+<span id="cb9-51"><a href="#cb9-51"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-52"><a href="#cb9-52"></a></span>
+<span id="cb9-53"><a href="#cb9-53"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-55"><a href="#cb9-55"></a>  out,</span>
+<span id="cb9-56"><a href="#cb9-56"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-57"><a href="#cb9-57"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Patients Who Discontinued Early from Study"</span></span>
+<span id="cb9-58"><a href="#cb9-58"></a>)</span>
+<span id="cb9-59"><a href="#cb9-59"></a></span>
+<span id="cb9-60"><a href="#cb9-60"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-61"><a href="#cb9-61"></a><span class="in">```</span></span>
+<span id="cb9-62"><a href="#cb9-62"></a></span>
+<span id="cb9-63"><a href="#cb9-63"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-64"><a href="#cb9-64"></a></span>
+<span id="cb9-65"><a href="#cb9-65"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-66"><a href="#cb9-66"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ONCL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Individual Efficacy Data</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="oncl01_cache/html/setup_09995e43812337ad86c1c39963198e1f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>out_ex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">select</span>(ID, AVAL)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>out_rs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Investigator End Of Induction Response"</span>, <span class="st">"Best Confirmed Overall Response by Investigator"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">select</span>(ID, AVALC, PARAM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">id_cols =</span> ID,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">right_join</span>(out_ex, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adtte_flt <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"OS"</span>, <span class="st">"PFS"</span>, <span class="st">"CRSD"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">PARAM =</span> <span class="fu">paste</span>(PARAM, <span class="fu">paste0</span>(<span class="st">"("</span>, AVALU, <span class="st">")"</span>), <span class="at">sep =</span> <span class="st">" "</span>), <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">trigeventpfs =</span> <span class="fu">ifelse</span>(CNSR <span class="sc">==</span> <span class="dv">0</span>, EVNTDESC, <span class="cn">NA</span>)</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  )</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a><span class="co"># Select triggering event variable</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>out_trg <span class="ot">&lt;-</span> adtte_flt <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">select</span>(ID, trigeventpfs)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a>out_tte <span class="ot">&lt;-</span> adtte_flt <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="fu">select</span>(ID, TRT01A, PARAM, AVAL, trigeventpfs) <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(ID, TRT01A),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="fu">mutate_at</span>(</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="fu">c</span>(<span class="st">"Overall Survival (DAYS)"</span>, <span class="st">"Progression Free Survival (DAYS)"</span>, <span class="st">"Duration of Confirmed Response (DAYS)"</span>),</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="cf">function</span>(x) <span class="fu">format</span>(<span class="fu">round</span>(x, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>)</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">select</span>(ID, TRT01A, <span class="st">`</span><span class="at">Overall Survival (DAYS)</span><span class="st">`</span>, <span class="st">`</span><span class="at">Progression Free Survival (DAYS)</span><span class="st">`</span>, <span class="st">`</span><span class="at">Duration of Confirmed Response (DAYS)</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="fu">right_join</span>(out_trg, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>)</span>
+<span id="cb1-49"><a href="#cb1-49"></a></span>
+<span id="cb1-50"><a href="#cb1-50"></a>out <span class="ot">&lt;-</span> out_tte <span class="sc">%&gt;%</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">right_join</span>(out_rs, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="fu">select</span>(</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    <span class="st">"ID"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVAL"</span>, <span class="st">"Best Confirmed Overall Response by Investigator"</span>, <span class="st">"Investigator End Of Induction Response"</span>, <span class="st">"Overall Survival (DAYS)"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    <span class="st">"Progression Free Survival (DAYS)"</span>, <span class="st">"trigeventpfs"</span>, <span class="st">"Duration of Confirmed Response (DAYS)"</span></span>
+<span id="cb1-55"><a href="#cb1-55"></a>  )</span>
+<span id="cb1-56"><a href="#cb1-56"></a></span>
+<span id="cb1-57"><a href="#cb1-57"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-58"><a href="#cb1-58"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-59"><a href="#cb1-59"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>    <span class="at">AVAL =</span> <span class="st">"Number of Doses</span><span class="sc">\n</span><span class="st">Received"</span>,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>    <span class="st">`</span><span class="at">Best Confirmed Overall Response by Investigator</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Best Confirmed</span><span class="sc">\n</span><span class="st">Overall Response</span><span class="sc">\n</span><span class="st">by Investigator"</span>,</span>
+<span id="cb1-64"><a href="#cb1-64"></a>    <span class="st">`</span><span class="at">Investigator End Of Induction Response</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Investigator</span><span class="sc">\n</span><span class="st">End Of Induction</span><span class="sc">\n</span><span class="st">Response"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">trigeventpfs =</span> <span class="st">"Triggering Event</span><span class="sc">\n</span><span class="st"> for PFS"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    <span class="st">`</span><span class="at">Overall Survival (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Overall Survival</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb1-67"><a href="#cb1-67"></a>    <span class="st">`</span><span class="at">Progression Free Survival (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"PFS</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb1-68"><a href="#cb1-68"></a>    <span class="st">`</span><span class="at">Duration of Confirmed Response (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Duration of</span><span class="sc">\n</span><span class="st">Confirmed Response</span><span class="sc">\n</span><span class="st">(days)"</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="oncl01_cache/html/lsting_0f97d11f35f2d3f5f39f11cba822660d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Individual Efficacy Data"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"PFS = Progression Free Survival"</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Individual Efficacy Data
+
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                        Best Confirmed      Investigator                                                          Duration of    
+                                     Number of Doses   Overall Response   End Of Induction   Overall Survival    PFS      Triggering Event     Confirmed Response
+Center/Patient ID     Treatment         Received       by Investigator        Response            (days)        (days)         for PFS               (days)      
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-105        A: Drug X             7                 CR                 CR               402.6         235.7    Disease Progression         119.6       
+                                            7                 CR                 CR               402.6         235.7            NA                  119.6       
+                                            7                 CR                 CR               402.6         235.7            NA                  119.6       
+  BRA-1/id-134        A: Drug X             7                 CR                 CR                90.1          90.1           Death                 90.1       
+                                            7                 CR                 CR                90.1          90.1           Death                 90.1       
+                                            7                 CR                 CR                90.1          90.1           Death                 90.1       
+  BRA-1/id-141      C: Combination          7                 CR                 PR               422.9         216.3            NA                  123.0       
+                                            7                 CR                 PR               422.9         216.3            NA                  123.0       
+                                            7                 CR                 PR               422.9         216.3            NA                  123.0       
+  BRA-1/id-236        B: Placebo            7                 PR                 SD               240.8         240.8            NA                  118.8       
+                                            7                 PR                 SD               240.8         240.8           Death                118.8       
+                                            7                 PR                 SD               240.8         240.8           Death                118.8       
+  BRA-1/id-265      C: Combination          7                 CR                 PD               130.9         130.9           Death                130.9       
+                                            7                 CR                 PD               130.9         130.9           Death                130.9       
+                                            7                 CR                 PD               130.9         130.9           Death                130.9       
+   BRA-1/id-42        A: Drug X             7                 PR                 PR               407.0         204.6    Disease Progression         193.9       
+                                            7                 PR                 PR               407.0         204.6            NA                  193.9       
+                                            7                 PR                 PR               407.0         204.6            NA                  193.9       
+   BRA-1/id-65        B: Placebo            7                 PR                 SD               332.6         288.1            NA                  190.6       
+                                            7                 PR                 SD               332.6         288.1            NA                  190.6       
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+PFS = Progression Free Survival</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="oncl01_cache/html/sessioninfo_1a21768895f809145ec23f7f7386b26c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     
+[5] scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="oncl01_cache/html/snapshot_216672b96da7be4bce179dbac8557117">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/efficacy/oncl01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> ONCL01</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Individual Efficacy Data</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb7-22"><a href="#cb7-22"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb7-23"><a href="#cb7-23"></a></span>
+<span id="cb7-24"><a href="#cb7-24"></a>out_ex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb7-25"><a href="#cb7-25"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-26"><a href="#cb7-26"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-27"><a href="#cb7-27"></a>  <span class="fu">select</span>(ID, AVAL)</span>
+<span id="cb7-28"><a href="#cb7-28"></a></span>
+<span id="cb7-29"><a href="#cb7-29"></a>out_rs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb7-30"><a href="#cb7-30"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Investigator End Of Induction Response"</span>, <span class="st">"Best Confirmed Overall Response by Investigator"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-31"><a href="#cb7-31"></a>  <span class="fu">mutate</span>(<span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-32"><a href="#cb7-32"></a>  <span class="fu">select</span>(ID, AVALC, PARAM) <span class="sc">%&gt;%</span></span>
+<span id="cb7-33"><a href="#cb7-33"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-34"><a href="#cb7-34"></a>    <span class="at">id_cols =</span> ID,</span>
+<span id="cb7-35"><a href="#cb7-35"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb7-36"><a href="#cb7-36"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb7-37"><a href="#cb7-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-38"><a href="#cb7-38"></a>  <span class="fu">right_join</span>(out_ex, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>)</span>
+<span id="cb7-39"><a href="#cb7-39"></a></span>
+<span id="cb7-40"><a href="#cb7-40"></a>adtte_flt <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb7-41"><a href="#cb7-41"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"OS"</span>, <span class="st">"PFS"</span>, <span class="st">"CRSD"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-42"><a href="#cb7-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="at">PARAM =</span> <span class="fu">paste</span>(PARAM, <span class="fu">paste0</span>(<span class="st">"("</span>, AVALU, <span class="st">")"</span>), <span class="at">sep =</span> <span class="st">" "</span>), <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-44"><a href="#cb7-44"></a>    <span class="at">trigeventpfs =</span> <span class="fu">ifelse</span>(CNSR <span class="sc">==</span> <span class="dv">0</span>, EVNTDESC, <span class="cn">NA</span>)</span>
+<span id="cb7-45"><a href="#cb7-45"></a>  )</span>
+<span id="cb7-46"><a href="#cb7-46"></a></span>
+<span id="cb7-47"><a href="#cb7-47"></a><span class="co"># Select triggering event variable</span></span>
+<span id="cb7-48"><a href="#cb7-48"></a>out_trg <span class="ot">&lt;-</span> adtte_flt <span class="sc">%&gt;%</span></span>
+<span id="cb7-49"><a href="#cb7-49"></a>  <span class="fu">select</span>(ID, trigeventpfs)</span>
+<span id="cb7-50"><a href="#cb7-50"></a></span>
+<span id="cb7-51"><a href="#cb7-51"></a>out_tte <span class="ot">&lt;-</span> adtte_flt <span class="sc">%&gt;%</span></span>
+<span id="cb7-52"><a href="#cb7-52"></a>  <span class="fu">select</span>(ID, TRT01A, PARAM, AVAL, trigeventpfs) <span class="sc">%&gt;%</span></span>
+<span id="cb7-53"><a href="#cb7-53"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-54"><a href="#cb7-54"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(ID, TRT01A),</span>
+<span id="cb7-55"><a href="#cb7-55"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb7-56"><a href="#cb7-56"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb7-57"><a href="#cb7-57"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-58"><a href="#cb7-58"></a>  <span class="fu">mutate_at</span>(</span>
+<span id="cb7-59"><a href="#cb7-59"></a>    <span class="fu">c</span>(<span class="st">"Overall Survival (DAYS)"</span>, <span class="st">"Progression Free Survival (DAYS)"</span>, <span class="st">"Duration of Confirmed Response (DAYS)"</span>),</span>
+<span id="cb7-60"><a href="#cb7-60"></a>    <span class="cf">function</span>(x) <span class="fu">format</span>(<span class="fu">round</span>(x, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>)</span>
+<span id="cb7-61"><a href="#cb7-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-62"><a href="#cb7-62"></a>  <span class="fu">select</span>(ID, TRT01A, <span class="st">`</span><span class="at">Overall Survival (DAYS)</span><span class="st">`</span>, <span class="st">`</span><span class="at">Progression Free Survival (DAYS)</span><span class="st">`</span>, <span class="st">`</span><span class="at">Duration of Confirmed Response (DAYS)</span><span class="st">`</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-63"><a href="#cb7-63"></a>  <span class="fu">right_join</span>(out_trg, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>)</span>
+<span id="cb7-64"><a href="#cb7-64"></a></span>
+<span id="cb7-65"><a href="#cb7-65"></a>out <span class="ot">&lt;-</span> out_tte <span class="sc">%&gt;%</span></span>
+<span id="cb7-66"><a href="#cb7-66"></a>  <span class="fu">right_join</span>(out_rs, ., <span class="at">by =</span> <span class="st">"ID"</span>, <span class="at">multiple =</span> <span class="st">"all"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-67"><a href="#cb7-67"></a>  <span class="fu">select</span>(</span>
+<span id="cb7-68"><a href="#cb7-68"></a>    <span class="st">"ID"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVAL"</span>, <span class="st">"Best Confirmed Overall Response by Investigator"</span>, <span class="st">"Investigator End Of Induction Response"</span>, <span class="st">"Overall Survival (DAYS)"</span>,</span>
+<span id="cb7-69"><a href="#cb7-69"></a>    <span class="st">"Progression Free Survival (DAYS)"</span>, <span class="st">"trigeventpfs"</span>, <span class="st">"Duration of Confirmed Response (DAYS)"</span></span>
+<span id="cb7-70"><a href="#cb7-70"></a>  )</span>
+<span id="cb7-71"><a href="#cb7-71"></a></span>
+<span id="cb7-72"><a href="#cb7-72"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb7-73"><a href="#cb7-73"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb7-74"><a href="#cb7-74"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb7-75"><a href="#cb7-75"></a>    <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-76"><a href="#cb7-76"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-77"><a href="#cb7-77"></a>    <span class="at">AVAL =</span> <span class="st">"Number of Doses</span><span class="sc">\n</span><span class="st">Received"</span>,</span>
+<span id="cb7-78"><a href="#cb7-78"></a>    <span class="st">`</span><span class="at">Best Confirmed Overall Response by Investigator</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Best Confirmed</span><span class="sc">\n</span><span class="st">Overall Response</span><span class="sc">\n</span><span class="st">by Investigator"</span>,</span>
+<span id="cb7-79"><a href="#cb7-79"></a>    <span class="st">`</span><span class="at">Investigator End Of Induction Response</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Investigator</span><span class="sc">\n</span><span class="st">End Of Induction</span><span class="sc">\n</span><span class="st">Response"</span>,</span>
+<span id="cb7-80"><a href="#cb7-80"></a>    <span class="at">trigeventpfs =</span> <span class="st">"Triggering Event</span><span class="sc">\n</span><span class="st"> for PFS"</span>,</span>
+<span id="cb7-81"><a href="#cb7-81"></a>    <span class="st">`</span><span class="at">Overall Survival (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Overall Survival</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb7-82"><a href="#cb7-82"></a>    <span class="st">`</span><span class="at">Progression Free Survival (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"PFS</span><span class="sc">\n</span><span class="st">(days)"</span>,</span>
+<span id="cb7-83"><a href="#cb7-83"></a>    <span class="st">`</span><span class="at">Duration of Confirmed Response (DAYS)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"Duration of</span><span class="sc">\n</span><span class="st">Confirmed Response</span><span class="sc">\n</span><span class="st">(days)"</span></span>
+<span id="cb7-84"><a href="#cb7-84"></a>  )</span>
+<span id="cb7-85"><a href="#cb7-85"></a><span class="in">```</span></span>
+<span id="cb7-86"><a href="#cb7-86"></a></span>
+<span id="cb7-87"><a href="#cb7-87"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-88"><a href="#cb7-88"></a></span>
+<span id="cb7-89"><a href="#cb7-89"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-90"><a href="#cb7-90"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-91"><a href="#cb7-91"></a>  out,</span>
+<span id="cb7-92"><a href="#cb7-92"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-93"><a href="#cb7-93"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-94"><a href="#cb7-94"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Individual Efficacy Data"</span>,</span>
+<span id="cb7-95"><a href="#cb7-95"></a>  <span class="at">main_footer =</span> <span class="st">"PFS = Progression Free Survival"</span></span>
+<span id="cb7-96"><a href="#cb7-96"></a>)</span>
+<span id="cb7-97"><a href="#cb7-97"></a></span>
+<span id="cb7-98"><a href="#cb7-98"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-99"><a href="#cb7-99"></a><span class="in">```</span></span>
+<span id="cb7-100"><a href="#cb7-100"></a></span>
+<span id="cb7-101"><a href="#cb7-101"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-102"><a href="#cb7-102"></a></span>
+<span id="cb7-103"><a href="#cb7-103"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-104"><a href="#cb7-104"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/exposure/exl01.html b/stable/listings/exposure/exl01.html
new file mode 100644
index 0000000000..d36f2262a8
--- /dev/null
+++ b/stable/listings/exposure/exl01.html
@@ -0,0 +1,2063 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - EXL01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../listings/lab-results/lbl01.html" rel="next">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+  }
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+
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+  'anonymizeIp': true,
+});
+</script><script type="text/javascript" charset="UTF-8">
+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
+  });
+});
+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - EXL01">
+<meta property="og:description" content="Listing of Exposure to Study Drug">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="../../index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
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+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
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+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/exposure/exl01.html">Exposure</a></li><li class="breadcrumb-item"><a href="../../listings/exposure/exl01.html">EXL01</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="true">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EXL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Exposure to Study Drug</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="exl01_cache/html/setup_1adf92b5e200a0c92417ed03d574bf10">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"DOSE"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">arrange</span>(CRTNPT, AVISIT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">select</span>(CRTNPT, AVISIT, EXSTDY, EXENDY, TRT01A, AVAL, AVALU, EXDOSFRQ, EXROUTE)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">EXSTDY =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">From"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">EXENDY =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">To"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">AVAL =</span> <span class="st">"Dose"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">AVALU =</span> <span class="st">"Unit"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">EXDOSFRQ =</span> <span class="st">"Frequency"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">EXROUTE =</span> <span class="st">"Route"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="exl01_cache/html/lsting_3ee49fda2bd3de1c08f1173fb8122a36">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Exposure to Study Drug"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Exposure to Study Drug
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                    Study Day   Study Day                                                          
+Center/Subject ID       Visit         From         To         Treatment      Dose   Unit   Frequency      Route    
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-105        SCREENING        -1          -1         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+                      BASELINE          1           1         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+                    WEEK 1 DAY 8        8           8         A: Drug X      720     mg      ONCE      SUBCUTANEOUS
+                    WEEK 2 DAY 15      15          15         A: Drug X      480     mg      ONCE      INTRAVENOUS 
+                    WEEK 3 DAY 22      22          22         A: Drug X      480     mg      ONCE      INTRAVENOUS 
+                    WEEK 4 DAY 29      29          29         A: Drug X      720     mg      ONCE      INTRAVENOUS 
+                    WEEK 5 DAY 36      36          36         A: Drug X      720     mg      ONCE      INTRAVENOUS 
+  BRA-1/id-134        SCREENING        -1          -1         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+                      BASELINE          1           1         A: Drug X      720     mg      ONCE      INTRAVENOUS 
+                    WEEK 1 DAY 8        8           8         A: Drug X      720     mg      ONCE      INTRAVENOUS 
+                    WEEK 2 DAY 15      15          15         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+                    WEEK 3 DAY 22      22          22         A: Drug X      720     mg      ONCE      INTRAVENOUS 
+                    WEEK 4 DAY 29      29          29         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+                    WEEK 5 DAY 36      36          36         A: Drug X      960     mg      ONCE      INTRAVENOUS 
+  BRA-1/id-141        SCREENING        -1          -1       C: Combination   960     mg      ONCE      INTRAVENOUS 
+                      BASELINE          1           1       C: Combination   720     mg      ONCE      SUBCUTANEOUS
+                    WEEK 1 DAY 8        8           8       C: Combination   720     mg      ONCE      INTRAVENOUS 
+                    WEEK 2 DAY 15      15          15       C: Combination   960     mg      ONCE      INTRAVENOUS 
+                    WEEK 3 DAY 22      22          22       C: Combination   1200    mg      ONCE      INTRAVENOUS 
+                    WEEK 4 DAY 29      29          29       C: Combination   1200    mg      ONCE      INTRAVENOUS </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="exl01_cache/html/sessioninfo_993c756c99e2c688e14440610599ce82">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="exl01_cache/html/snapshot_93124afa99110ea863af73fc6744e3a9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/exposure/exl01.lock">Download</a></p>
+</section>
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+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
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+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
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+      if (cites) {
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+      }
+    } else {
+      return undefined;
+    }
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../listings/efficacy/oncl01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ONCL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/lab-results/lbl01.html" class="pagination-link">
+        <span class="nav-page-text">LBL01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> EXL01</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Exposure to Study Drug</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>out <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"DOSE"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)</span>
+<span id="cb7-26"><a href="#cb7-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-27"><a href="#cb7-27"></a>  <span class="fu">arrange</span>(CRTNPT, AVISIT) <span class="sc">%&gt;%</span></span>
+<span id="cb7-28"><a href="#cb7-28"></a>  <span class="fu">select</span>(CRTNPT, AVISIT, EXSTDY, EXENDY, TRT01A, AVAL, AVALU, EXDOSFRQ, EXROUTE)</span>
+<span id="cb7-29"><a href="#cb7-29"></a></span>
+<span id="cb7-30"><a href="#cb7-30"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb7-31"><a href="#cb7-31"></a>  <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb7-32"><a href="#cb7-32"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>  <span class="at">EXSTDY =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">From"</span>,</span>
+<span id="cb7-34"><a href="#cb7-34"></a>  <span class="at">EXENDY =</span> <span class="st">"Study Day</span><span class="sc">\n</span><span class="st">To"</span>,</span>
+<span id="cb7-35"><a href="#cb7-35"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-36"><a href="#cb7-36"></a>  <span class="at">AVAL =</span> <span class="st">"Dose"</span>,</span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="at">AVALU =</span> <span class="st">"Unit"</span>,</span>
+<span id="cb7-38"><a href="#cb7-38"></a>  <span class="at">EXDOSFRQ =</span> <span class="st">"Frequency"</span>,</span>
+<span id="cb7-39"><a href="#cb7-39"></a>  <span class="at">EXROUTE =</span> <span class="st">"Route"</span></span>
+<span id="cb7-40"><a href="#cb7-40"></a>)</span>
+<span id="cb7-41"><a href="#cb7-41"></a><span class="in">```</span></span>
+<span id="cb7-42"><a href="#cb7-42"></a></span>
+<span id="cb7-43"><a href="#cb7-43"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-44"><a href="#cb7-44"></a></span>
+<span id="cb7-45"><a href="#cb7-45"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-46"><a href="#cb7-46"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-47"><a href="#cb7-47"></a>  out,</span>
+<span id="cb7-48"><a href="#cb7-48"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb7-49"><a href="#cb7-49"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-50"><a href="#cb7-50"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Exposure to Study Drug"</span></span>
+<span id="cb7-51"><a href="#cb7-51"></a>)</span>
+<span id="cb7-52"><a href="#cb7-52"></a></span>
+<span id="cb7-53"><a href="#cb7-53"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-54"><a href="#cb7-54"></a><span class="in">```</span></span>
+<span id="cb7-55"><a href="#cb7-55"></a></span>
+<span id="cb7-56"><a href="#cb7-56"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-57"><a href="#cb7-57"></a></span>
+<span id="cb7-58"><a href="#cb7-58"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-59"><a href="#cb7-59"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/lab-results/lbl01.html b/stable/listings/lab-results/lbl01.html
new file mode 100644
index 0000000000..d8fb074882
--- /dev/null
+++ b/stable/listings/lab-results/lbl01.html
@@ -0,0 +1,2117 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBL01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Laboratory Test Results</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbl01_cache/html/setup_e93920f41dcd28ec8dc7c1e71d1542a0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(LBSEQ) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(ADY) <span class="sc">&amp;</span> ANRIND <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAMCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">" / NCI CTCAE grade)"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb1-17"><a href="#cb1-17"></a>      ),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"H"</span>, <span class="st">"L"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    ),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">AVALC =</span> <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_GR =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"H"</span>, <span class="st">"L"</span>),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    AVALC,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="fu">paste</span>(AVALC, <span class="fu">paste0</span>(ANRIND, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)), <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-29"><a href="#cb1-29"></a></span>
+<span id="cb1-30"><a href="#cb1-30"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">arrange</span>(CPID, ADY, PARAM_U, LBSEQ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, CPID, ADY),</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">values_from =</span> AVAL_GR</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="fu">group_by</span>(CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, DLD, <span class="fu">unique</span>(adlb_x<span class="sc">$</span>PARAM_U))</span>
+<span id="cb1-41"><a href="#cb1-41"></a></span>
+<span id="cb1-42"><a href="#cb1-42"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-43"><a href="#cb1-43"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="lbl01_cache/html/lsting_30cfd222f4e2b64eff3f23e38ed338c1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Test Results"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Laboratory Test Results
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                              Days Since                                                                                
+                                     Study   Last Dose of             ALT                       CRP                        IGA          
+Center/Patient ID     Treatment       Day     Study Drug    (U/L / NCI CTCAE grade)   (mg/L / NCI CTCAE grade)   (g/L / NCI CTCAE grade)
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-105        A: Drug X       80          NA               4.30 / L4                    9.09                      2.84          
+                                      149         69                 24.70                      9.15                      2.93          
+                                      314        165                 24.87                   10.89 / H2                   2.66          
+                                      398         84               3.67 / L3                    8.14                      2.86          
+                                      470         72                 18.55                   10.59 / H3                   2.88          
+                                      528         58                 7.73                    10.09 / H3                   2.93          
+                                      535         7                  23.51                      9.20                      2.88          
+  BRA-1/id-134        A: Drug X       225         NA                 7.37                    10.46 / H1                   2.86          
+                                      227         2                  16.42                   7.43 / L1                    2.76          
+                                      255         28                 11.16                      9.41                      2.75          
+                                      269         14                 15.89                   10.02 / H4                   2.84          
+                                      357         88                 24.35                      8.01                      2.86          
+                                      436         79                 16.03                      8.51                      2.98          
+                                      440         4                  17.21                   7.63 / L3                    2.78          
+  BRA-1/id-141      C: Combination     4          NA                 11.32                      9.21                      2.84          
+                                      52          48                 25.77                   10.00 / H2                   2.69          
+                                      189        137                 32.73                      9.08                      2.85          
+                                      262         73                 34.69                      8.81                      2.81          
+                                      386        124                 8.58                       8.81                      2.81          
+                                      425         39                 19.58                      8.79                      2.87          
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbl01_cache/html/sessioninfo_d4c08103c9dec8ccb756f0f0fddee660">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbl01_cache/html/snapshot_9ffd334894ecd465e4c2255dfcc4bbfd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/lab-results/lbl01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
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+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
+    } else {
+      localAlternateSentinel = value;
+    }
+  }
+  const getColorSchemeSentinel = () => {
+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
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+        { trigger: "manual", 
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+    }
+    setTimeout(function() {
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+    // clear code selection
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+                     window.document.getElementById('quarto-code-tools-source');
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+        if (codeDiv.classList.contains(fromCls)) {
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+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+        let height = null;
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+            height = bottom - top;
+          }
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
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+      const unselectCodeLines = () => {
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+          if (div) {
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+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
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+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+      }
+  const findCites = (el) => {
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+          el,
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+      }
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+    }
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/exposure/exl01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EXL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/lab-results/lbl01_rls.html" class="pagination-link">
+        <span class="nav-page-text">LBL01_RLS</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> LBL01</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Laboratory Test Results</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(LBSEQ) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(ADY) <span class="sc">&amp;</span> ANRIND <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAMCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">" / NCI CTCAE grade)"</span>),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb7-28"><a href="#cb7-28"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb7-29"><a href="#cb7-29"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb7-30"><a href="#cb7-30"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb7-31"><a href="#cb7-31"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb7-32"><a href="#cb7-32"></a>      ),</span>
+<span id="cb7-33"><a href="#cb7-33"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"H"</span>, <span class="st">"L"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb7-34"><a href="#cb7-34"></a>    ),</span>
+<span id="cb7-35"><a href="#cb7-35"></a>    <span class="at">AVALC =</span> <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb7-36"><a href="#cb7-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_GR =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"H"</span>, <span class="st">"L"</span>),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    AVALC,</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="fu">paste</span>(AVALC, <span class="fu">paste0</span>(ANRIND, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)), <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb7-41"><a href="#cb7-41"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb7-42"><a href="#cb7-42"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb7-43"><a href="#cb7-43"></a>  <span class="fu">unique</span>()</span>
+<span id="cb7-44"><a href="#cb7-44"></a></span>
+<span id="cb7-45"><a href="#cb7-45"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb7-46"><a href="#cb7-46"></a>  <span class="fu">arrange</span>(CPID, ADY, PARAM_U, LBSEQ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-48"><a href="#cb7-48"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, CPID, ADY),</span>
+<span id="cb7-49"><a href="#cb7-49"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb7-50"><a href="#cb7-50"></a>    <span class="at">values_from =</span> AVAL_GR</span>
+<span id="cb7-51"><a href="#cb7-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-52"><a href="#cb7-52"></a>  <span class="fu">group_by</span>(CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb7-53"><a href="#cb7-53"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-54"><a href="#cb7-54"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb7-55"><a href="#cb7-55"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, DLD, <span class="fu">unique</span>(adlb_x<span class="sc">$</span>PARAM_U))</span>
+<span id="cb7-56"><a href="#cb7-56"></a></span>
+<span id="cb7-57"><a href="#cb7-57"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb7-58"><a href="#cb7-58"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb7-59"><a href="#cb7-59"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb7-60"><a href="#cb7-60"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-61"><a href="#cb7-61"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-62"><a href="#cb7-62"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb7-63"><a href="#cb7-63"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span></span>
+<span id="cb7-64"><a href="#cb7-64"></a>  )</span>
+<span id="cb7-65"><a href="#cb7-65"></a><span class="in">```</span></span>
+<span id="cb7-66"><a href="#cb7-66"></a></span>
+<span id="cb7-67"><a href="#cb7-67"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-68"><a href="#cb7-68"></a></span>
+<span id="cb7-69"><a href="#cb7-69"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-70"><a href="#cb7-70"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-71"><a href="#cb7-71"></a>  out,</span>
+<span id="cb7-72"><a href="#cb7-72"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-73"><a href="#cb7-73"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-74"><a href="#cb7-74"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Test Results"</span>,</span>
+<span id="cb7-75"><a href="#cb7-75"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb7-76"><a href="#cb7-76"></a>)</span>
+<span id="cb7-77"><a href="#cb7-77"></a></span>
+<span id="cb7-78"><a href="#cb7-78"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-79"><a href="#cb7-79"></a><span class="in">```</span></span>
+<span id="cb7-80"><a href="#cb7-80"></a></span>
+<span id="cb7-81"><a href="#cb7-81"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-82"><a href="#cb7-82"></a></span>
+<span id="cb7-83"><a href="#cb7-83"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-84"><a href="#cb7-84"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/lab-results/lbl01_rls.html b/stable/listings/lab-results/lbl01_rls.html
new file mode 100644
index 0000000000..15c8af2822
--- /dev/null
+++ b/stable/listings/lab-results/lbl01_rls.html
@@ -0,0 +1,2130 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBL01_RLS</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBL01_RLS</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Laboratory Test Results Using Roche Safety Lab Standardization</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbl01_rls_cache/html/setup_0fb45c09f6b98c8ebbccda89684240ea">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL))</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(<span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="fu">case_when</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>)) <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb1-12"><a href="#cb1-12"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>)) <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>)) <span class="sc">~</span> <span class="st">"LL"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>)) <span class="sc">~</span> <span class="st">"HH"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    ),</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"H"</span>, <span class="st">"HH"</span>, <span class="st">"L"</span>, <span class="st">"LL"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  ))</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a>adlb_x <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(LBSEQ) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(ADY) <span class="sc">&amp;</span> ANRIND <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAMCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">AVALC =</span> <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_GR =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"H"</span>, <span class="st">"HH"</span>, <span class="st">"L"</span>, <span class="st">"LL"</span>),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    AVALC,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="fu">paste</span>(AVALC, ANRIND, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-34"><a href="#cb1-34"></a></span>
+<span id="cb1-35"><a href="#cb1-35"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>  <span class="fu">arrange</span>(CPID, ADY, PARAM_U, LBSEQ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, CPID, ADY),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">values_from =</span> AVAL_GR</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">group_by</span>(CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, DLD, <span class="fu">unique</span>(adlb_x<span class="sc">$</span>PARAM_U))</span>
+<span id="cb1-46"><a href="#cb1-46"></a></span>
+<span id="cb1-47"><a href="#cb1-47"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-48"><a href="#cb1-48"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="lbl01_rls_cache/html/lsting_6e26a34be6f43627683e89acd50f18e9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Test Results Using Roche Safety Lab Standardization"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"Abnormalities are flagged as high (H) or low (L) if outside the Roche standard reference range; high high (HH) or low low (LL) if</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">  outside the Roche marked reference range with a clinically relevant change from baseline. "</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Laboratory Test Results Using Roche Safety Lab Standardization
+
+—————————————————————————————————————————————————————————————————————————————————————————
+                                              Days Since                                 
+                                     Study   Last Dose of      ALT         CRP       IGA 
+Center/Patient ID     Treatment       Day     Study Drug      (U/L)      (mg/L)     (g/L)
+—————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-105        A: Drug X       80          NA        4.30 / L      9.09      2.84 
+                                      149         69          24.70       9.15      2.93 
+                                      314        165          24.87     10.89 / H   2.66 
+                                      398         84        3.67 / L      8.14      2.86 
+                                      470         72          18.55     10.59 / H   2.88 
+                                      528         58          7.73      10.09 / H   2.93 
+                                      535         7           23.51       9.20      2.88 
+  BRA-1/id-134        A: Drug X       225         NA          7.37      10.46 / H   2.86 
+                                      227         2           16.42     7.43 / L    2.76 
+                                      255         28          11.16       9.41      2.75 
+                                      269         14          15.89     10.02 / H   2.84 
+                                      357         88          24.35       8.01      2.86 
+                                      436         79          16.03       8.51      2.98 
+                                      440         4           17.21     7.63 / L    2.78 
+  BRA-1/id-141      C: Combination     4          NA          11.32       9.21      2.84 
+                                      52          48          25.77     10.00 / H   2.69 
+                                      189        137          32.73       9.08      2.85 
+                                      262         73          34.69       8.81      2.81 
+                                      386        124          8.58        8.81      2.81 
+                                      425         39          19.58       8.79      2.87 
+—————————————————————————————————————————————————————————————————————————————————————————
+
+Abnormalities are flagged as high (H) or low (L) if outside the Roche standard reference range; high high (HH) or low low (LL) if
+  outside the Roche marked reference range with a clinically relevant change from baseline. </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbl01_rls_cache/html/sessioninfo_70c5ac8fd837b6dbc3bfebde8fda6207">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbl01_rls_cache/html/snapshot_2752b0030cd36d5e7064143e842fa7a3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/lab-results/lbl01_rls.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
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+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+    for (let i=0; i < stylesheets.length; i++) {
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+      stylesheet.rel = 'stylesheet';
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+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
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+      } else {
+        el.classList.add('notransition');
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+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
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+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> LBL01_RLS</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Laboratory Test Results Using Roche Safety Lab Standardization</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-21"><a href="#cb7-21"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL))</span>
+<span id="cb7-22"><a href="#cb7-22"></a></span>
+<span id="cb7-23"><a href="#cb7-23"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb7-24"><a href="#cb7-24"></a>  <span class="fu">mutate</span>(<span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="fu">case_when</span>(</span>
+<span id="cb7-26"><a href="#cb7-26"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>)) <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb7-27"><a href="#cb7-27"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>)) <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb7-28"><a href="#cb7-28"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>)) <span class="sc">~</span> <span class="st">"LL"</span>,</span>
+<span id="cb7-29"><a href="#cb7-29"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> stats<span class="sc">::</span><span class="fu">quantile</span>(adlb<span class="sc">$</span>AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>)) <span class="sc">~</span> <span class="st">"HH"</span>,</span>
+<span id="cb7-30"><a href="#cb7-30"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb7-31"><a href="#cb7-31"></a>    ),</span>
+<span id="cb7-32"><a href="#cb7-32"></a>    <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"H"</span>, <span class="st">"HH"</span>, <span class="st">"L"</span>, <span class="st">"LL"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb7-33"><a href="#cb7-33"></a>  ))</span>
+<span id="cb7-34"><a href="#cb7-34"></a></span>
+<span id="cb7-35"><a href="#cb7-35"></a>adlb_x <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb7-36"><a href="#cb7-36"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(LBSEQ) <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(ADY) <span class="sc">&amp;</span> ANRIND <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAMCD, <span class="st">"</span><span class="sc">\n</span><span class="st">("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="at">AVALC =</span> <span class="fu">as.character</span>(<span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>))</span>
+<span id="cb7-41"><a href="#cb7-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-42"><a href="#cb7-42"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_GR =</span> <span class="fu">ifelse</span>(</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"H"</span>, <span class="st">"HH"</span>, <span class="st">"L"</span>, <span class="st">"LL"</span>),</span>
+<span id="cb7-44"><a href="#cb7-44"></a>    AVALC,</span>
+<span id="cb7-45"><a href="#cb7-45"></a>    <span class="fu">paste</span>(AVALC, ANRIND, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb7-46"><a href="#cb7-46"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb7-48"><a href="#cb7-48"></a>  <span class="fu">unique</span>()</span>
+<span id="cb7-49"><a href="#cb7-49"></a></span>
+<span id="cb7-50"><a href="#cb7-50"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb7-51"><a href="#cb7-51"></a>  <span class="fu">arrange</span>(CPID, ADY, PARAM_U, LBSEQ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-52"><a href="#cb7-52"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-53"><a href="#cb7-53"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, CPID, ADY),</span>
+<span id="cb7-54"><a href="#cb7-54"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb7-55"><a href="#cb7-55"></a>    <span class="at">values_from =</span> AVAL_GR</span>
+<span id="cb7-56"><a href="#cb7-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-57"><a href="#cb7-57"></a>  <span class="fu">group_by</span>(CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb7-58"><a href="#cb7-58"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-59"><a href="#cb7-59"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb7-60"><a href="#cb7-60"></a>  <span class="fu">select</span>(CPID, TRT01A, ADY, DLD, <span class="fu">unique</span>(adlb_x<span class="sc">$</span>PARAM_U))</span>
+<span id="cb7-61"><a href="#cb7-61"></a></span>
+<span id="cb7-62"><a href="#cb7-62"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb7-63"><a href="#cb7-63"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb7-64"><a href="#cb7-64"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb7-65"><a href="#cb7-65"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-66"><a href="#cb7-66"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb7-67"><a href="#cb7-67"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb7-68"><a href="#cb7-68"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span></span>
+<span id="cb7-69"><a href="#cb7-69"></a>  )</span>
+<span id="cb7-70"><a href="#cb7-70"></a><span class="in">```</span></span>
+<span id="cb7-71"><a href="#cb7-71"></a></span>
+<span id="cb7-72"><a href="#cb7-72"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-73"><a href="#cb7-73"></a></span>
+<span id="cb7-74"><a href="#cb7-74"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-75"><a href="#cb7-75"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-76"><a href="#cb7-76"></a>  out,</span>
+<span id="cb7-77"><a href="#cb7-77"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CPID"</span>, <span class="st">"TRT01A"</span>),</span>
+<span id="cb7-78"><a href="#cb7-78"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-79"><a href="#cb7-79"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Test Results Using Roche Safety Lab Standardization"</span>,</span>
+<span id="cb7-80"><a href="#cb7-80"></a>  <span class="at">main_footer =</span> <span class="st">"Abnormalities are flagged as high (H) or low (L) if outside the Roche standard reference range; high high (HH) or low low (LL) if</span></span>
+<span id="cb7-81"><a href="#cb7-81"></a><span class="st">  outside the Roche marked reference range with a clinically relevant change from baseline. "</span></span>
+<span id="cb7-82"><a href="#cb7-82"></a>)</span>
+<span id="cb7-83"><a href="#cb7-83"></a></span>
+<span id="cb7-84"><a href="#cb7-84"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-85"><a href="#cb7-85"></a><span class="in">```</span></span>
+<span id="cb7-86"><a href="#cb7-86"></a></span>
+<span id="cb7-87"><a href="#cb7-87"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-88"><a href="#cb7-88"></a></span>
+<span id="cb7-89"><a href="#cb7-89"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-90"><a href="#cb7-90"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/listings/lab-results/lbl02a.html b/stable/listings/lab-results/lbl02a.html
new file mode 100644
index 0000000000..b84718ab7a
--- /dev/null
+++ b/stable/listings/lab-results/lbl02a.html
@@ -0,0 +1,2119 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
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+    padding: 0 4px; width: 4em;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+<!-- sidebar -->
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+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
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+        <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">ADA</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBL02A</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Laboratory Abnormalities (constant units)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbl02a_cache/html/setup_1011b159a867cdbe16ee6bd96e478f05">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"HIGH"</span>),</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="sc">!</span>ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"0"</span>, <span class="st">""</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">LBTEST_U =</span> <span class="fu">paste0</span>(LBTEST, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">ADTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ADTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(<span class="fu">format</span>(<span class="fu">round</span>(ANRLO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="fu">format</span>(<span class="fu">round</span>(ANRHI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">ANRIND_GR =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"L"</span>, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"H"</span>, ATOXGR)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      )</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    )</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, ADTM, AVAL, ADY, LBNRNG, ANRIND_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">group_by</span>(LBTEST_U, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb1-33"><a href="#cb1-33"></a></span>
+<span id="cb1-34"><a href="#cb1-34"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, ADTM, DLD, AVAL, LBNRNG, ANRIND_GR)</span>
+<span id="cb1-36"><a href="#cb1-36"></a></span>
+<span id="cb1-37"><a href="#cb1-37"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-38"><a href="#cb1-38"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">LBTEST_U =</span> <span class="st">"Lab Test (Unit)"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">ADTM =</span> <span class="st">"Date"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">LBNRNG =</span> <span class="st">"Lab Normal</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">ANRIND_GR =</span> <span class="st">"NCI</span><span class="sc">\n</span><span class="st">CTCAE</span><span class="sc">\n</span><span class="st">Grade"</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="lbl02a_cache/html/lsting_ac1bff4724c24f7b5aa1152a0727047d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST_U"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 1"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 1
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                  Days Since                           NCI 
+                                                                             Study               Last Dose of            Lab Normal   CTCAE
+             Lab Test (Unit)                 Treatment   Center/Patient ID    Day      Date       Study Drug    Result     Range      Grade
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (U/L)   A: Drug X     BRA-1/id-105       80     27MAY2020        0          4.3     7.0 - 55.0    L4  
+                                                                              398    10APR2021       318         3.7     7.0 - 55.0    L3  
+                                                            BRA-1/id-93       207    13JAN2021        0          6.1     7.0 - 55.0    L1  
+                                                           BRA-11/id-397      326    19MAY2021        0          1.5     7.0 - 55.0    L1  
+                                                           BRA-14/id-23       594    22JUN2021        0          0.6     7.0 - 55.0    L1  
+                                                           BRA-2/id-296       281    30OCT2021        0          2.6     7.0 - 55.0    L1  
+                                                                              734    26JAN2023       453         3.9     7.0 - 55.0    L1  
+                                                            CAN-1/id-18       465    12APR2022        0          1.8     7.0 - 55.0    L2  
+                                                           CHN-1/id-133       127    13DEC2020        0          5.6     7.0 - 55.0    L2  
+                                                                              197    21FEB2021        70         1.2     7.0 - 55.0    L4  
+                                                           CHN-1/id-199       277    11OCT2020        0          5.3     7.0 - 55.0    L4  
+                                                                              672    10NOV2021       395         6.8     7.0 - 55.0    L2  
+                                                           CHN-1/id-235       348    25JUN2020        0          3.0     7.0 - 55.0    L3  
+                                                                              381    28JUL2020        33         4.7     7.0 - 55.0    L1  
+                                                            CHN-1/id-26       905    07JAN2023        0          1.1     7.0 - 55.0    L1  
+                                                           CHN-1/id-275       364    01JUN2021        0          5.1     7.0 - 55.0    L2  
+                                                           CHN-1/id-277       483    12MAY2022        0          1.1     7.0 - 55.0    L4  
+                                                           CHN-1/id-287       182    23MAY2020        0          5.9     7.0 - 55.0    L2  
+                                                                              191    01JUN2020        9          5.3     7.0 - 55.0    L3  
+                                                                              515    21APR2021       324         2.9     7.0 - 55.0    L4  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbl02a_cache/html/sessioninfo_23daee7e7fbe8d4b1ee01be9293e4077">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbl02a_cache/html/snapshot_bfa68babf172248c6c834db696cb42d2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/lab-results/lbl02a.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/lab-results/lbl01_rls.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBL01_RLS</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/lab-results/lbl02a_rls.html" class="pagination-link">
+        <span class="nav-page-text">LBL02A_RLS</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> LBL02A</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Laboratory Abnormalities (constant units)</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"HIGH"</span>),</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="sc">!</span>ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"0"</span>, <span class="st">""</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span></span>
+<span id="cb9-27"><a href="#cb9-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-28"><a href="#cb9-28"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-29"><a href="#cb9-29"></a>    <span class="at">LBTEST_U =</span> <span class="fu">paste0</span>(LBTEST, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb9-30"><a href="#cb9-30"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-31"><a href="#cb9-31"></a>    <span class="at">ADTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ADTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(<span class="fu">format</span>(<span class="fu">round</span>(ANRLO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="fu">format</span>(<span class="fu">round</span>(ANRHI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">ANRIND_GR =</span> <span class="fu">factor</span>(</span>
+<span id="cb9-35"><a href="#cb9-35"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb9-36"><a href="#cb9-36"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"L"</span>, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)),</span>
+<span id="cb9-37"><a href="#cb9-37"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"H"</span>, ATOXGR)</span>
+<span id="cb9-38"><a href="#cb9-38"></a>      )</span>
+<span id="cb9-39"><a href="#cb9-39"></a>    )</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, ADTM, AVAL, ADY, LBNRNG, ANRIND_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="fu">group_by</span>(LBTEST_U, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, ADTM, DLD, AVAL, LBNRNG, ANRIND_GR)</span>
+<span id="cb9-51"><a href="#cb9-51"></a></span>
+<span id="cb9-52"><a href="#cb9-52"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-53"><a href="#cb9-53"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb9-55"><a href="#cb9-55"></a>    <span class="at">LBTEST_U =</span> <span class="st">"Lab Test (Unit)"</span>,</span>
+<span id="cb9-56"><a href="#cb9-56"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-57"><a href="#cb9-57"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-58"><a href="#cb9-58"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb9-59"><a href="#cb9-59"></a>    <span class="at">ADTM =</span> <span class="st">"Date"</span>,</span>
+<span id="cb9-60"><a href="#cb9-60"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb9-61"><a href="#cb9-61"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb9-62"><a href="#cb9-62"></a>    <span class="at">LBNRNG =</span> <span class="st">"Lab Normal</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb9-63"><a href="#cb9-63"></a>    <span class="at">ANRIND_GR =</span> <span class="st">"NCI</span><span class="sc">\n</span><span class="st">CTCAE</span><span class="sc">\n</span><span class="st">Grade"</span></span>
+<span id="cb9-64"><a href="#cb9-64"></a>  )</span>
+<span id="cb9-65"><a href="#cb9-65"></a><span class="in">```</span></span>
+<span id="cb9-66"><a href="#cb9-66"></a></span>
+<span id="cb9-67"><a href="#cb9-67"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-68"><a href="#cb9-68"></a></span>
+<span id="cb9-69"><a href="#cb9-69"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-70"><a href="#cb9-70"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-71"><a href="#cb9-71"></a>  out,</span>
+<span id="cb9-72"><a href="#cb9-72"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST_U"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb9-73"><a href="#cb9-73"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-74"><a href="#cb9-74"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 1"</span>,</span>
+<span id="cb9-75"><a href="#cb9-75"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb9-76"><a href="#cb9-76"></a>)</span>
+<span id="cb9-77"><a href="#cb9-77"></a></span>
+<span id="cb9-78"><a href="#cb9-78"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-79"><a href="#cb9-79"></a><span class="in">```</span></span>
+<span id="cb9-80"><a href="#cb9-80"></a></span>
+<span id="cb9-81"><a href="#cb9-81"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-82"><a href="#cb9-82"></a></span>
+<span id="cb9-83"><a href="#cb9-83"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-84"><a href="#cb9-84"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/listings/lab-results/lbl02a_rls.html b/stable/listings/lab-results/lbl02a_rls.html
new file mode 100644
index 0000000000..ef1173c8a0
--- /dev/null
+++ b/stable/listings/lab-results/lbl02a_rls.html
@@ -0,0 +1,2166 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBL02A_RLS</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
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+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
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+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/lab-results/lbl01.html">Lab Results</a></li><li class="breadcrumb-item"><a href="../../listings/lab-results/lbl02a_rls.html">LBL02A_RLS</a></li></ol></nav>
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+    </div>
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+<!-- sidebar -->
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">ADA</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBL02A_RLS</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbl02a_rls_cache/html/setup_7f25c864d612448582e9a294ac23ea17">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">LBTEST_U =</span> <span class="fu">paste0</span>(LBTEST, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">mutate</span>(<span class="at">CRC =</span> <span class="fu">paste</span>(<span class="st">"40%"</span>, <span class="st">"40%"</span>, <span class="at">sep =</span> <span class="st">" / "</span>))</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>std_rng <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">group_by</span>(LBTEST_U) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">STD_RNG_LO =</span> stats<span class="sc">::</span><span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>), <span class="at">na.rm =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">STD_RNG_HI =</span> stats<span class="sc">::</span><span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adlb_x <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">left_join</span>(std_rng, <span class="at">by =</span> <span class="st">"LBTEST_U"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">PCHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(PCHG, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(ANRLO, ANRHI, <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">STD_RNG_LO =</span> <span class="fu">format</span>(<span class="fu">round</span>(STD_RNG_LO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">STD_RNG_HI =</span> <span class="fu">format</span>(<span class="fu">round</span>(STD_RNG_HI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">STD_RNG =</span> <span class="fu">paste</span>(STD_RNG_LO, STD_RNG_HI, <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;</span> STD_RNG_LO <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> STD_RNG_HI <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> STD_RNG_LO <span class="sc">~</span> <span class="st">"LL"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> STD_RNG_HI <span class="sc">~</span> <span class="st">"HH"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>    ))</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND) <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">group_by</span>(LBTEST_U, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb1-51"><a href="#cb1-51"></a></span>
+<span id="cb1-52"><a href="#cb1-52"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, DLD, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND)</span>
+<span id="cb1-54"><a href="#cb1-54"></a></span>
+<span id="cb1-55"><a href="#cb1-55"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-56"><a href="#cb1-56"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    <span class="at">LBTEST_U =</span> <span class="st">"Lab Test (Unit)"</span>,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb1-64"><a href="#cb1-64"></a>    <span class="at">PCHG =</span> <span class="st">"% Change</span><span class="sc">\n</span><span class="st">from</span><span class="sc">\n</span><span class="st">Baseline"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">STD_RNG =</span> <span class="st">"Standard</span><span class="sc">\n</span><span class="st">Reference</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    <span class="at">LBNRNG =</span> <span class="st">"Marked</span><span class="sc">\n</span><span class="st">Reference</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb1-67"><a href="#cb1-67"></a>    <span class="at">CRC =</span> <span class="st">"Clinically</span><span class="sc">\n</span><span class="st">Relevant</span><span class="sc">\n</span><span class="st">Change</span><span class="sc">\n</span><span class="st">Dec./Inc."</span>,</span>
+<span id="cb1-68"><a href="#cb1-68"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality</span><span class="sc">\n</span><span class="st">Flag"</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="lbl02a_rls_cache/html/lsting_2f8ea3dbe3a49144e2a6dcac2eaadb4b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST_U"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"Standard reference range, marked reference range and clinically relevant change from baseline are from the Roche Safety Lab</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">Standardization guideline.  Abnormalities are flagged as high (H) or low (L) if outside the standard reference range; high high (HH)</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="st">or low low (LL) if outside the marked reference range with a clinically relevant change from baseline."</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                                                                  Clinically              
+                                                                                      Days Since             % Change     Standard     Marked      Relevant               
+                                                                             Study   Last Dose of              from      Reference    Reference     Change     Abnormality
+             Lab Test (Unit)                 Treatment   Center/Patient ID    Day     Study Drug    Result   Baseline      Range        Range     Dec./Inc.       Flag    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (U/L)   A: Drug X     BRA-1/id-105       80          0          4.3        NA       5.5 - 31.1    7 - 55     40% / 40%        LL     
+                                                                              149         69         24.7       0.0      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              314        165         24.9       0.7      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              398         84         3.7       -85.2     5.5 - 31.1    7 - 55     40% / 40%        LL     
+                                                                              470         72         18.5      -24.9     5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              528         58         7.7       -68.7     5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              535         7          23.5      -4.8      5.5 - 31.1    7 - 55     40% / 40%               
+                                                           BRA-1/id-134       225         0          7.4        NA       5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              227         2          16.4       0.0      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              255         28         11.2      -32.0     5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              269         14         15.9      -3.2      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              357         88         24.4      48.3      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              436         79         16.0      -2.4      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              440         4          17.2       4.8      5.5 - 31.1    7 - 55     40% / 40%               
+                                                            BRA-1/id-42       176         0          16.6       NA       5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              477        301         16.5       0.0      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              534         57         18.7      13.4      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              550         16         11.4      -30.6     5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              569         19         21.7      31.3      5.5 - 31.1    7 - 55     40% / 40%               
+                                                                              608         39         24.6      49.2      5.5 - 31.1    7 - 55     40% / 40%               
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+Standard reference range, marked reference range and clinically relevant change from baseline are from the Roche Safety Lab
+Standardization guideline.  Abnormalities are flagged as high (H) or low (L) if outside the standard reference range; high high (HH)
+or low low (LL) if outside the marked reference range with a clinically relevant change from baseline.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbl02a_rls_cache/html/sessioninfo_344c68af471b7de473ae62f3dd17c7f7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbl02a_rls_cache/html/snapshot_f0401580cea8f6656e3fe141aa72c784">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/lab-results/lbl02a_rls.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
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+    // flash "checked"
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+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/lab-results/lbl02a.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBL02A</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/lab-results/lbl02b.html" class="pagination-link">
+        <span class="nav-page-text">LBL02B</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> LBL02A_RLS</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-26"><a href="#cb9-26"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">LBTEST_U =</span> <span class="fu">paste0</span>(LBTEST, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>)</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">mutate</span>(<span class="at">CRC =</span> <span class="fu">paste</span>(<span class="st">"40%"</span>, <span class="st">"40%"</span>, <span class="at">sep =</span> <span class="st">" / "</span>))</span>
+<span id="cb9-31"><a href="#cb9-31"></a></span>
+<span id="cb9-32"><a href="#cb9-32"></a>std_rng <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a>  <span class="fu">group_by</span>(LBTEST_U) <span class="sc">%&gt;%</span></span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="fu">summarise</span>(</span>
+<span id="cb9-35"><a href="#cb9-35"></a>    <span class="at">STD_RNG_LO =</span> stats<span class="sc">::</span><span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>), <span class="at">na.rm =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb9-36"><a href="#cb9-36"></a>    <span class="at">STD_RNG_HI =</span> stats<span class="sc">::</span><span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.9</span>), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb9-39"><a href="#cb9-39"></a></span>
+<span id="cb9-40"><a href="#cb9-40"></a>adlb_x <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="fu">left_join</span>(std_rng, <span class="at">by =</span> <span class="st">"LBTEST_U"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-43"><a href="#cb9-43"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb9-44"><a href="#cb9-44"></a>    <span class="at">PCHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(PCHG, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb9-45"><a href="#cb9-45"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(ANRLO, ANRHI, <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb9-46"><a href="#cb9-46"></a>    <span class="at">STD_RNG_LO =</span> <span class="fu">format</span>(<span class="fu">round</span>(STD_RNG_LO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb9-47"><a href="#cb9-47"></a>    <span class="at">STD_RNG_HI =</span> <span class="fu">format</span>(<span class="fu">round</span>(STD_RNG_HI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>)</span>
+<span id="cb9-48"><a href="#cb9-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-50"><a href="#cb9-50"></a>    <span class="at">STD_RNG =</span> <span class="fu">paste</span>(STD_RNG_LO, STD_RNG_HI, <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb9-51"><a href="#cb9-51"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb9-52"><a href="#cb9-52"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;</span> STD_RNG_LO <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb9-53"><a href="#cb9-53"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> STD_RNG_HI <span class="sc">~</span> <span class="st">"H"</span>,</span>
+<span id="cb9-54"><a href="#cb9-54"></a>      ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> STD_RNG_LO <span class="sc">~</span> <span class="st">"LL"</span>,</span>
+<span id="cb9-55"><a href="#cb9-55"></a>      ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> STD_RNG_HI <span class="sc">~</span> <span class="st">"HH"</span>,</span>
+<span id="cb9-56"><a href="#cb9-56"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb9-57"><a href="#cb9-57"></a>    ))</span>
+<span id="cb9-58"><a href="#cb9-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-59"><a href="#cb9-59"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND) <span class="sc">%&gt;%</span></span>
+<span id="cb9-60"><a href="#cb9-60"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-61"><a href="#cb9-61"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb9-62"><a href="#cb9-62"></a>  <span class="fu">group_by</span>(LBTEST_U, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb9-63"><a href="#cb9-63"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-64"><a href="#cb9-64"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-65"><a href="#cb9-65"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb9-66"><a href="#cb9-66"></a></span>
+<span id="cb9-67"><a href="#cb9-67"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-68"><a href="#cb9-68"></a>  <span class="fu">select</span>(LBTEST_U, TRT01A, CPID, ADY, DLD, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND)</span>
+<span id="cb9-69"><a href="#cb9-69"></a></span>
+<span id="cb9-70"><a href="#cb9-70"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-71"><a href="#cb9-71"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb9-72"><a href="#cb9-72"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb9-73"><a href="#cb9-73"></a>    <span class="at">LBTEST_U =</span> <span class="st">"Lab Test (Unit)"</span>,</span>
+<span id="cb9-74"><a href="#cb9-74"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-75"><a href="#cb9-75"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-76"><a href="#cb9-76"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb9-77"><a href="#cb9-77"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb9-78"><a href="#cb9-78"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb9-79"><a href="#cb9-79"></a>    <span class="at">PCHG =</span> <span class="st">"% Change</span><span class="sc">\n</span><span class="st">from</span><span class="sc">\n</span><span class="st">Baseline"</span>,</span>
+<span id="cb9-80"><a href="#cb9-80"></a>    <span class="at">STD_RNG =</span> <span class="st">"Standard</span><span class="sc">\n</span><span class="st">Reference</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb9-81"><a href="#cb9-81"></a>    <span class="at">LBNRNG =</span> <span class="st">"Marked</span><span class="sc">\n</span><span class="st">Reference</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb9-82"><a href="#cb9-82"></a>    <span class="at">CRC =</span> <span class="st">"Clinically</span><span class="sc">\n</span><span class="st">Relevant</span><span class="sc">\n</span><span class="st">Change</span><span class="sc">\n</span><span class="st">Dec./Inc."</span>,</span>
+<span id="cb9-83"><a href="#cb9-83"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality</span><span class="sc">\n</span><span class="st">Flag"</span></span>
+<span id="cb9-84"><a href="#cb9-84"></a>  )</span>
+<span id="cb9-85"><a href="#cb9-85"></a><span class="in">```</span></span>
+<span id="cb9-86"><a href="#cb9-86"></a></span>
+<span id="cb9-87"><a href="#cb9-87"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-88"><a href="#cb9-88"></a></span>
+<span id="cb9-89"><a href="#cb9-89"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-90"><a href="#cb9-90"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-91"><a href="#cb9-91"></a>  out,</span>
+<span id="cb9-92"><a href="#cb9-92"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST_U"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb9-93"><a href="#cb9-93"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-94"><a href="#cb9-94"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization"</span>,</span>
+<span id="cb9-95"><a href="#cb9-95"></a>  <span class="at">main_footer =</span> <span class="st">"Standard reference range, marked reference range and clinically relevant change from baseline are from the Roche Safety Lab</span></span>
+<span id="cb9-96"><a href="#cb9-96"></a><span class="st">Standardization guideline.  Abnormalities are flagged as high (H) or low (L) if outside the standard reference range; high high (HH)</span></span>
+<span id="cb9-97"><a href="#cb9-97"></a><span class="st">or low low (LL) if outside the marked reference range with a clinically relevant change from baseline."</span></span>
+<span id="cb9-98"><a href="#cb9-98"></a>)</span>
+<span id="cb9-99"><a href="#cb9-99"></a></span>
+<span id="cb9-100"><a href="#cb9-100"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-101"><a href="#cb9-101"></a><span class="in">```</span></span>
+<span id="cb9-102"><a href="#cb9-102"></a></span>
+<span id="cb9-103"><a href="#cb9-103"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-104"><a href="#cb9-104"></a></span>
+<span id="cb9-105"><a href="#cb9-105"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-106"><a href="#cb9-106"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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+++ b/stable/listings/lab-results/lbl02b.html
@@ -0,0 +1,2121 @@
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+ <span class="menu-text">AET02_SMQ</span></a>
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+ <span class="menu-text">AET03</span></a>
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+ <span class="menu-text">AET04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET09</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">DTHT01</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
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+  </div>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBL02B</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Laboratory Abnormalities (variable units)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbl02b_cache/html/setup_8ad6968454dcba11e1dcf39425077873">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    <span class="sc">!</span><span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR) <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span>,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="sc">!</span><span class="fu">is.na</span>(ADY),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">ADTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ADTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(<span class="fu">format</span>(<span class="fu">round</span>(ANRLO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="fu">format</span>(<span class="fu">round</span>(ANRHI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">ANRIND_GR =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"L"</span>, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"H"</span>, ATOXGR)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      )</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    )</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">select</span>(LBTEST, TRT01A, CPID, ADY, ADTM, AVAL, AVALU, LBNRNG, ANRIND_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">group_by</span>(LBTEST, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb1-33"><a href="#cb1-33"></a></span>
+<span id="cb1-34"><a href="#cb1-34"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">select</span>(LBTEST, TRT01A, CPID, ADY, ADTM, DLD, AVAL, AVALU, LBNRNG, ANRIND_GR)</span>
+<span id="cb1-36"><a href="#cb1-36"></a></span>
+<span id="cb1-37"><a href="#cb1-37"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-38"><a href="#cb1-38"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">LBTEST =</span> <span class="st">"Lab Test"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">ADTM =</span> <span class="st">"Date"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">AVALU =</span> <span class="st">"Unit"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">LBNRNG =</span> <span class="st">"Lab Normal</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">ANRIND_GR =</span> <span class="st">"NCI</span><span class="sc">\n</span><span class="st">CTCAE</span><span class="sc">\n</span><span class="st">Grade"</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="lbl02b_cache/html/lsting_67454b9d9f642b33953b5c8710d617e6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 2"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 2
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                            Days Since                                  NCI 
+                                                                       Study               Last Dose of                   Lab Normal   CTCAE
+              Lab Test                 Treatment   Center/Patient ID    Day      Date       Study Drug    Result   Unit     Range      Grade
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement   A: Drug X     BRA-1/id-105       80     27MAY2020        0          4.3     U/L    7.0 - 55.0    L4  
+                                                                        398    10APR2021       318         3.7     U/L    7.0 - 55.0    L3  
+                                                      CAN-1/id-18       465    12APR2022        0          1.8     U/L    7.0 - 55.0    L2  
+                                                     CHN-1/id-133       127    13DEC2020        0          5.6     U/L    7.0 - 55.0    L2  
+                                                                        197    21FEB2021        70         1.2     U/L    7.0 - 55.0    L4  
+                                                     CHN-1/id-199       277    11OCT2020        0          5.3     U/L    7.0 - 55.0    L4  
+                                                                        672    10NOV2021       395         6.8     U/L    7.0 - 55.0    L2  
+                                                     CHN-1/id-235       348    25JUN2020        0          3.0     U/L    7.0 - 55.0    L3  
+                                                     CHN-1/id-275       364    01JUN2021        0          5.1     U/L    7.0 - 55.0    L2  
+                                                     CHN-1/id-277       483    12MAY2022        0          1.1     U/L    7.0 - 55.0    L4  
+                                                     CHN-1/id-287       182    23MAY2020        0          5.9     U/L    7.0 - 55.0    L2  
+                                                                        191    01JUN2020        9          5.3     U/L    7.0 - 55.0    L3  
+                                                                        515    21APR2021       324         2.9     U/L    7.0 - 55.0    L4  
+                                                     CHN-1/id-315       289    05JUN2020        0          4.6     U/L    7.0 - 55.0    L4  
+                                                                        599    11APR2021       310         5.2     U/L    7.0 - 55.0    L4  
+                                                     CHN-1/id-316       971    14MAY2023        0          3.6     U/L    7.0 - 55.0    L4  
+                                                     CHN-1/id-360       689    01APR2022        0          4.7     U/L    7.0 - 55.0    L2  
+                                                     CHN-1/id-371       81     01MAY2021        0          5.9     U/L    7.0 - 55.0    L2  
+                                                      CHN-1/id-47       236    11SEP2020        0          4.4     U/L    7.0 - 55.0    L3  
+                                                      CHN-1/id-53       98     13FEB2020        0          6.4     U/L    7.0 - 55.0    L2  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbl02b_cache/html/sessioninfo_ae0eb8a06cfefc16221b36786e62542f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbl02b_cache/html/snapshot_754dac54bd93d36eeb2b1ee1cbddd457">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/lab-results/lbl02b.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> LBL02B</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Laboratory Abnormalities (variable units)</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>adlb_x <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    <span class="sc">!</span><span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR) <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    LBTEST <span class="sc">!=</span> <span class="st">""</span>,</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="sc">!</span><span class="fu">is.na</span>(ADY),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="sc">!</span>ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb9-28"><a href="#cb9-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-30"><a href="#cb9-30"></a>    <span class="at">CPID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-31"><a href="#cb9-31"></a>    <span class="at">ADTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ADTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>),</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">LBNRNG =</span> <span class="fu">paste</span>(<span class="fu">format</span>(<span class="fu">round</span>(ANRLO, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="fu">format</span>(<span class="fu">round</span>(ANRHI, <span class="dv">1</span>), <span class="at">nsmall =</span> <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">" - "</span>),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">ANRIND_GR =</span> <span class="fu">factor</span>(</span>
+<span id="cb9-35"><a href="#cb9-35"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb9-36"><a href="#cb9-36"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"L"</span>, <span class="fu">sub</span>(<span class="st">"-"</span>, <span class="st">""</span>, ATOXGR)),</span>
+<span id="cb9-37"><a href="#cb9-37"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">~</span> <span class="fu">paste0</span>(<span class="st">"H"</span>, ATOXGR)</span>
+<span id="cb9-38"><a href="#cb9-38"></a>      )</span>
+<span id="cb9-39"><a href="#cb9-39"></a>    )</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="fu">select</span>(LBTEST, TRT01A, CPID, ADY, ADTM, AVAL, AVALU, LBNRNG, ANRIND_GR) <span class="sc">%&gt;%</span></span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="fu">arrange</span>(CPID, ADY) <span class="sc">%&gt;%</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="fu">group_by</span>(LBTEST, CPID) <span class="sc">%&gt;%</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> ADY <span class="sc">-</span> <span class="fu">lag</span>(ADY)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a>  <span class="fu">mutate</span>(<span class="at">DLD =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(DLD), <span class="dv">0</span>, DLD))</span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a>out <span class="ot">&lt;-</span> adlb_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>  <span class="fu">select</span>(LBTEST, TRT01A, CPID, ADY, ADTM, DLD, AVAL, AVALU, LBNRNG, ANRIND_GR)</span>
+<span id="cb9-51"><a href="#cb9-51"></a></span>
+<span id="cb9-52"><a href="#cb9-52"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-53"><a href="#cb9-53"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span></span>
+<span id="cb9-54"><a href="#cb9-54"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb9-55"><a href="#cb9-55"></a>    <span class="at">LBTEST =</span> <span class="st">"Lab Test"</span>,</span>
+<span id="cb9-56"><a href="#cb9-56"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-57"><a href="#cb9-57"></a>    <span class="at">CPID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-58"><a href="#cb9-58"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb9-59"><a href="#cb9-59"></a>    <span class="at">ADTM =</span> <span class="st">"Date"</span>,</span>
+<span id="cb9-60"><a href="#cb9-60"></a>    <span class="at">DLD =</span> <span class="st">"Days Since</span><span class="sc">\n</span><span class="st">Last Dose of</span><span class="sc">\n</span><span class="st">Study Drug"</span>,</span>
+<span id="cb9-61"><a href="#cb9-61"></a>    <span class="at">AVAL =</span> <span class="st">"Result"</span>,</span>
+<span id="cb9-62"><a href="#cb9-62"></a>    <span class="at">AVALU =</span> <span class="st">"Unit"</span>,</span>
+<span id="cb9-63"><a href="#cb9-63"></a>    <span class="at">LBNRNG =</span> <span class="st">"Lab Normal</span><span class="sc">\n</span><span class="st">Range"</span>,</span>
+<span id="cb9-64"><a href="#cb9-64"></a>    <span class="at">ANRIND_GR =</span> <span class="st">"NCI</span><span class="sc">\n</span><span class="st">CTCAE</span><span class="sc">\n</span><span class="st">Grade"</span></span>
+<span id="cb9-65"><a href="#cb9-65"></a>  )</span>
+<span id="cb9-66"><a href="#cb9-66"></a><span class="in">```</span></span>
+<span id="cb9-67"><a href="#cb9-67"></a></span>
+<span id="cb9-68"><a href="#cb9-68"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-69"><a href="#cb9-69"></a></span>
+<span id="cb9-70"><a href="#cb9-70"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-71"><a href="#cb9-71"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-72"><a href="#cb9-72"></a>  out,</span>
+<span id="cb9-73"><a href="#cb9-73"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"LBTEST"</span>, <span class="st">"TRT01A"</span>, <span class="st">"CPID"</span>),</span>
+<span id="cb9-74"><a href="#cb9-74"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-75"><a href="#cb9-75"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 2"</span>,</span>
+<span id="cb9-76"><a href="#cb9-76"></a>  <span class="at">main_footer =</span> <span class="st">"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade."</span></span>
+<span id="cb9-77"><a href="#cb9-77"></a>)</span>
+<span id="cb9-78"><a href="#cb9-78"></a></span>
+<span id="cb9-79"><a href="#cb9-79"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-80"><a href="#cb9-80"></a><span class="in">```</span></span>
+<span id="cb9-81"><a href="#cb9-81"></a></span>
+<span id="cb9-82"><a href="#cb9-82"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-83"><a href="#cb9-83"></a></span>
+<span id="cb9-84"><a href="#cb9-84"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-85"><a href="#cb9-85"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
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+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/medical-history/mhl01.html b/stable/listings/medical-history/mhl01.html
new file mode 100644
index 0000000000..fef26ed9d4
--- /dev/null
+++ b/stable/listings/medical-history/mhl01.html
@@ -0,0 +1,2074 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - MHL01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
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+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
+    "search-label": "Search"
+  }
+}</script><script type="text/plain" cookie-consent="tracking">
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+
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+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
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+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - MHL01">
+<meta property="og:description" content="Listing of Medical History and Concurrent Diseases">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="../../index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/development" rel="" target="">
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+  </li>  
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/medical-history/mhl01.html">Medical History</a></li><li class="breadcrumb-item"><a href="../../listings/medical-history/mhl01.html">MHL01</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="true">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MHL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Medical History and Concurrent Diseases</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mhl01_cache/html/setup_efe0cdf8f83f62e351c550865a0c2136">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>admh <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>out <span class="ot">&lt;-</span> admh <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">TRTSDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">ASTDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ASTDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">AENDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(AENDTM), <span class="st">"%d%b%Y"</span>))</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, MHBODSYS, MHDECOD, TRTSDTM, ASTDTM, ASTDY, AENDTM, AENDY, ATIREL)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">MHBODSYS =</span> <span class="st">"SOC"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">MHDECOD =</span> <span class="st">"Disease Term"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">TRTSDTM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">ASTDTM =</span> <span class="st">"Start Date</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">ASTDY =</span> <span class="st">"Start Day</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">AENDTM =</span> <span class="st">"End Date</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">AENDY =</span> <span class="st">"End Day</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">ATIREL =</span> <span class="st">"Time Relation</span><span class="sc">\n</span><span class="st">of Disease"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="mhl01_cache/html/lsting_355d8beef91f411ea202ef08e481dcd5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>, <span class="st">"MHBODSYS"</span>, <span class="st">"MHDECOD"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Medical History and Concurrent Diseases"</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Medical History and Concurrent Diseases
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                            Date of First                                                                         
+                                                                                              Study Drug     Start Date   Start Day     End Date     End Day       Time Relation  
+Center/Patient ID            Age/Sex/Race              Treatment      SOC    Disease Term   Administration   of Disease   of Disease   of Disease   of Disease      of Disease    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+  BRA-1/id-134                47/M/WHITE               A: Drug X      cl A    trm A_2/2       04NOV2020      21SEP2021       321       16FEB2022       469       PRIOR_CONCOMITANT
+                                                                                              04NOV2020      02DEC2021       393       13JAN2022       435       PRIOR_CONCOMITANT
+                                                                      cl B    trm B_2/3       04NOV2020      15APR2021       162       04OCT2021       334       PRIOR_CONCOMITANT
+                                                                      cl D    trm D_2/3       04NOV2020      19MAY2021       196       31OCT2021       361       PRIOR_CONCOMITANT
+  BRA-1/id-141                35/F/WHITE             C: Combination   cl A    trm A_1/2       25JUL2020      03AUG2022       739       07SEP2022       774       PRIOR_CONCOMITANT
+                                                                                              25JUL2020      03MAR2023       951       07MAY2023       1016      PRIOR_CONCOMITANT
+                                                                              trm A_2/2       25JUL2020      10JAN2023       899       28MAY2023       1037      PRIOR_CONCOMITANT
+                                                                      cl B    trm B_2/3       25JUL2020      16AUG2021       387       26AUG2021       397       PRIOR_CONCOMITANT
+                                                                      cl D    trm D_1/3       25JUL2020      23JUL2023       1093      25JUL2023       1095      PRIOR_CONCOMITANT
+                                                                              trm D_3/3       25JUL2020      23OCT2021       455       12JUL2023       1082      PRIOR_CONCOMITANT
+  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     cl B    trm B_1/3       15JAN2021      17FEB2021        33       23OCT2022       646       PRIOR_CONCOMITANT
+                                                                                              15JAN2021      13OCT2021       271       26NOV2023       1045      PRIOR_CONCOMITANT
+                                                                                              15JAN2021      02DEC2023       1051      08DEC2023       1057      PRIOR_CONCOMITANT
+  BRA-1/id-265                25/M/WHITE             C: Combination   cl C    trm C_1/2       07OCT2019      11SEP2021       705       15NOV2021       770       PRIOR_CONCOMITANT
+                                                                              trm C_2/2       07OCT2019      30DEC2019        84       16MAR2020       161       PRIOR_CONCOMITANT
+                                                                      cl D    trm D_1/3       07OCT2019      22AUG2021       685       27SEP2021       721       PRIOR_CONCOMITANT
+                                                                              trm D_2/3       07OCT2019      20SEP2020       349       01JUL2021       633       PRIOR_CONCOMITANT
+   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      cl A    trm A_2/2       01JAN2020      09JUN2020       160       22FEB2021       418       PRIOR_CONCOMITANT
+                                                                                              01JAN2020      04APR2021       459       15OCT2021       653       PRIOR_CONCOMITANT
+                                                                                              01JAN2020      20APR2021       475       10AUG2021       587       PRIOR_CONCOMITANT</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mhl01_cache/html/sessioninfo_03202c55e5d3e1742c1ef53086194d52">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mhl01_cache/html/snapshot_ae004f1f89ca1307c0f8b5e4eaf31049">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/medical-history/mhl01.lock">Download</a></p>
+</section>
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/lab-results/lbl02b.html" class="pagination-link">
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+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/pharmacokinetic/pkcl01.html" class="pagination-link">
+        <span class="nav-page-text">PKCL01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> MHL01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Medical History and Concurrent Diseases</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>admh <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>out <span class="ot">&lt;-</span> admh <span class="sc">%&gt;%</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    <span class="at">ASR =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">ID =</span> <span class="fu">paste</span>(SITEID, SUBJID, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">TRTSDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(TRTSDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">ASTDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(ASTDTM), <span class="st">"%d%b%Y"</span>)),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">AENDTM =</span> <span class="fu">toupper</span>(<span class="fu">format</span>(<span class="fu">as.Date</span>(AENDTM), <span class="st">"%d%b%Y"</span>))</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">select</span>(ID, ASR, TRT01A, MHBODSYS, MHDECOD, TRTSDTM, ASTDTM, ASTDY, AENDTM, AENDY, ATIREL)</span>
+<span id="cb9-31"><a href="#cb9-31"></a></span>
+<span id="cb9-32"><a href="#cb9-32"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>  <span class="at">ID =</span> <span class="st">"Center/Patient ID"</span>,</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="at">ASR =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb9-36"><a href="#cb9-36"></a>  <span class="at">MHBODSYS =</span> <span class="st">"SOC"</span>,</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  <span class="at">MHDECOD =</span> <span class="st">"Disease Term"</span>,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>  <span class="at">TRTSDTM =</span> <span class="st">"Date of First</span><span class="sc">\n</span><span class="st">Study Drug</span><span class="sc">\n</span><span class="st">Administration"</span>,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>  <span class="at">ASTDTM =</span> <span class="st">"Start Date</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">ASTDY =</span> <span class="st">"Start Day</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">AENDTM =</span> <span class="st">"End Date</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">AENDY =</span> <span class="st">"End Day</span><span class="sc">\n</span><span class="st">of Disease"</span>,</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">ATIREL =</span> <span class="st">"Time Relation</span><span class="sc">\n</span><span class="st">of Disease"</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a>)</span>
+<span id="cb9-45"><a href="#cb9-45"></a><span class="in">```</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a></span>
+<span id="cb9-47"><a href="#cb9-47"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  out,</span>
+<span id="cb9-52"><a href="#cb9-52"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ID"</span>, <span class="st">"ASR"</span>, <span class="st">"TRT01A"</span>, <span class="st">"MHBODSYS"</span>, <span class="st">"MHDECOD"</span>),</span>
+<span id="cb9-53"><a href="#cb9-53"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-54"><a href="#cb9-54"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Medical History and Concurrent Diseases"</span></span>
+<span id="cb9-55"><a href="#cb9-55"></a>)</span>
+<span id="cb9-56"><a href="#cb9-56"></a></span>
+<span id="cb9-57"><a href="#cb9-57"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-58"><a href="#cb9-58"></a><span class="in">```</span></span>
+<span id="cb9-59"><a href="#cb9-59"></a></span>
+<span id="cb9-60"><a href="#cb9-60"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-61"><a href="#cb9-61"></a></span>
+<span id="cb9-62"><a href="#cb9-62"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-63"><a href="#cb9-63"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
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+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/listings/pharmacokinetic/pkcl01.html b/stable/listings/pharmacokinetic/pkcl01.html
new file mode 100644
index 0000000000..0eed8f8a8c
--- /dev/null
+++ b/stable/listings/pharmacokinetic/pkcl01.html
@@ -0,0 +1,2060 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - PKCL01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../listings/pharmacokinetic/pkcl02.html" rel="next">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
+    "search-label": "Search"
+  }
+}</script><script type="text/plain" cookie-consent="tracking">
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+ga('create', 'UA-125641273-1', 'auto');
+
+ga('send', {
+  hitType: 'pageview',
+  'anonymizeIp': true,
+});
+</script><script type="text/javascript" charset="UTF-8">
+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
+  });
+});
+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - PKCL01">
+<meta property="og:description" content="Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="../../index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Listings</li><li class="breadcrumb-item"><a href="../../listings/pharmacokinetic/pkcl01.html">Pharmacokinetic</a></li><li class="breadcrumb-item"><a href="../../listings/pharmacokinetic/pkcl01.html">PKCL01</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkcl01_cache/html/setup_c31cde6a80e83b5f0c3d3abdcaf827b8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>analyte <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>out <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">filter</span>(PARAM <span class="sc">==</span> analyte) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">select</span>(ARM, USUBJID, VISIT, NFRLT, AFRLT, AVAL)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">ARM =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">VISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">NFRLT =</span> <span class="fu">paste0</span>(<span class="st">"Nominal Sampling</span><span class="sc">\n</span><span class="st">Time ("</span>, adpc<span class="sc">$</span>RELTMU[<span class="dv">1</span>], <span class="st">")"</span>),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">AFRLT =</span> <span class="fu">paste0</span>(<span class="st">"Actual Time</span><span class="sc">\n</span><span class="st">From First</span><span class="sc">\n</span><span class="st">Dose ("</span>, adpc<span class="sc">$</span>RELTMU[<span class="dv">1</span>], <span class="st">")"</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">AVAL =</span> <span class="fu">paste0</span>(<span class="st">"Concentration</span><span class="sc">\n</span><span class="st">("</span>, adpc<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="pkcl01_cache/html/lsting_d8e61ade103ddfb6bef62d138849d7db">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"USUBJID"</span>, <span class="st">"VISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, analyte, <span class="st">"Concentration by Treatment Group, Subject and Nominal Time, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, analyte)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Plasma Drug X Concentration by Treatment Group, Subject and Nominal Time, PK Population
+Protocol: xxnnnnn
+Analyte: Plasma Drug X
+
+———————————————————————————————————————————————————————————————————————————————————————————————
+                                                                    Actual Time                
+                                                 Nominal Sampling   From First    Concentration
+Treatment Group        Subject ID        Visit      Time (hr)        Dose (hr)       (ug/mL)   
+———————————————————————————————————————————————————————————————————————————————————————————————
+   A: Drug X      AB12345-BRA-1-id-105   Day 1          0                0              0      
+                                                       0.5              0.5          10.404    
+                                                        1                1           13.987    
+                                                       1.5              1.5          14.142    
+                                                        2                2           12.744    
+                                                        3                3            8.803    
+                                                        4                4            5.461    
+                                                        8                8            0.562    
+                                                        12              12            0.049    
+                                         Day 2          24              24              0      
+                  AB12345-BRA-1-id-134   Day 1          0                0              0      
+                                                       0.5              0.5          14.405    
+                                                        1                1           17.863    
+                                                       1.5              1.5          16.613    
+                                                        2                2           13.735    
+                                                        3                3            7.923    
+                                                        4                4            4.064    
+                                                        8                8            0.178    
+                                                        12              12            0.006    
+                                         Day 2          24              24              0      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkcl01_cache/html/sessioninfo_f3a0813aeb2d7e9bb08920101ab77877">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      scda_0.1.6       rlistings_0.2.4  tibble_3.2.1    
+[5] formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       
+ [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      
+[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    
+[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 
+[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0
+[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       
+[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      
+[33] tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkcl01_cache/html/snapshot_434a094f44fefff49669fae338905bbd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/pharmacokinetic/pkcl01.lock">Download</a></p>
+</section>
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+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
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+      for (const childEl of codeEl.children) {
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+          childEl.remove();
+        }
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+      return codeEl.innerText;
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+  });
+  clipboard.on('success', function(e) {
+    // button target
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+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
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+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
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+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
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+        let top = null;
+        let height = null;
+        let parent = null;
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+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/medical-history/mhl01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">MHL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/pharmacokinetic/pkcl02.html" class="pagination-link">
+        <span class="nav-page-text">PKCL02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> PKCL01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>analyte <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a></span>
+<span id="cb9-24"><a href="#cb9-24"></a>out <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a>  <span class="fu">filter</span>(PARAM <span class="sc">==</span> analyte) <span class="sc">%&gt;%</span></span>
+<span id="cb9-26"><a href="#cb9-26"></a>  <span class="fu">select</span>(ARM, USUBJID, VISIT, NFRLT, AFRLT, AVAL)</span>
+<span id="cb9-27"><a href="#cb9-27"></a></span>
+<span id="cb9-28"><a href="#cb9-28"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  <span class="at">ARM =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb9-31"><a href="#cb9-31"></a>  <span class="at">VISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>  <span class="at">NFRLT =</span> <span class="fu">paste0</span>(<span class="st">"Nominal Sampling</span><span class="sc">\n</span><span class="st">Time ("</span>, adpc<span class="sc">$</span>RELTMU[<span class="dv">1</span>], <span class="st">")"</span>),</span>
+<span id="cb9-33"><a href="#cb9-33"></a>  <span class="at">AFRLT =</span> <span class="fu">paste0</span>(<span class="st">"Actual Time</span><span class="sc">\n</span><span class="st">From First</span><span class="sc">\n</span><span class="st">Dose ("</span>, adpc<span class="sc">$</span>RELTMU[<span class="dv">1</span>], <span class="st">")"</span>),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  <span class="at">AVAL =</span> <span class="fu">paste0</span>(<span class="st">"Concentration</span><span class="sc">\n</span><span class="st">("</span>, adpc<span class="sc">$</span>AVALU[<span class="dv">1</span>], <span class="st">")"</span>)</span>
+<span id="cb9-35"><a href="#cb9-35"></a>)</span>
+<span id="cb9-36"><a href="#cb9-36"></a><span class="in">```</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a></span>
+<span id="cb9-38"><a href="#cb9-38"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-39"><a href="#cb9-39"></a></span>
+<span id="cb9-40"><a href="#cb9-40"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  out,</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"USUBJID"</span>, <span class="st">"VISIT"</span>),</span>
+<span id="cb9-44"><a href="#cb9-44"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-45"><a href="#cb9-45"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, analyte, <span class="st">"Concentration by Treatment Group, Subject and Nominal Time, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb9-46"><a href="#cb9-46"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, analyte)</span>
+<span id="cb9-47"><a href="#cb9-47"></a>)</span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-50"><a href="#cb9-50"></a><span class="in">```</span></span>
+<span id="cb9-51"><a href="#cb9-51"></a></span>
+<span id="cb9-52"><a href="#cb9-52"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-53"><a href="#cb9-53"></a></span>
+<span id="cb9-54"><a href="#cb9-54"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-55"><a href="#cb9-55"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/listings/pharmacokinetic/pkcl02.html b/stable/listings/pharmacokinetic/pkcl02.html
new file mode 100644
index 0000000000..3a7eb54b97
--- /dev/null
+++ b/stable/listings/pharmacokinetic/pkcl02.html
@@ -0,0 +1,2135 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - PKCL02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCL02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Drug A Urine Concentration and Volumes</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkcl02_cache/html/setup_1d2aa4a954a7979708c4c4ed25589f62">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Drug X"</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>spec <span class="ot">&lt;-</span> <span class="st">"URINE"</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adpc_x <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">mutate</span>(<span class="at">REGIMEN =</span> <span class="fu">ifelse</span>(<span class="st">"REGIMEN"</span> <span class="sc">%in%</span> <span class="fu">names</span>(adpc), REGIMEN, <span class="st">"BID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="fu">grepl</span>(drug_a, PARAM),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    ASMED <span class="sc">==</span> spec</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  )</span>
+<span id="cb1-15"><a href="#cb1-15"></a></span>
+<span id="cb1-16"><a href="#cb1-16"></a>out <span class="ot">&lt;-</span> adpc_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_longer</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">cols =</span> <span class="fu">c</span>(AVAL, PCVOL),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">names_to =</span> <span class="st">"URCD"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">values_to =</span> <span class="st">"VALUE"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">URCD =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      URCD <span class="sc">==</span> <span class="st">"AVAL"</span> <span class="sc">~</span> <span class="st">"UR_Conc"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      URCD <span class="sc">==</span> <span class="st">"PCVOL"</span> <span class="sc">~</span> <span class="st">"Vurine"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> URCD</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    ),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">UNIT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      URCD <span class="sc">==</span> <span class="st">"UR_Conc"</span> <span class="sc">~</span> <span class="fu">as.character</span>(AVALU),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      URCD <span class="sc">==</span> <span class="st">"Vurine"</span> <span class="sc">~</span> <span class="fu">as.character</span>(PCVOLU),</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NA"</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>    )</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">PARAM_INT =</span> <span class="fu">paste0</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      URCD, <span class="st">" ("</span>, UNIT, <span class="st">") -</span><span class="sc">\n</span><span class="st">Urine Collection</span><span class="sc">\n</span><span class="st">Interval"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      <span class="fu">ifelse</span>(PCTPT <span class="sc">==</span> <span class="st">"Predose"</span>, <span class="st">""</span>, <span class="st">" (hours)"</span>), <span class="st">":</span><span class="sc">\n</span><span class="st">"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="fu">gsub</span>(<span class="st">"[PTH]"</span>, <span class="st">""</span>, PCTPT)</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    )</span>
+<span id="cb1-40"><a href="#cb1-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>  <span class="fu">select</span>(TRT01A, USUBJID, VISIT, PARAM_INT, VALUE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, VISIT),</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">names_from =</span> PARAM_INT,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">values_from =</span> VALUE</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  )</span>
+<span id="cb1-48"><a href="#cb1-48"></a></span>
+<span id="cb1-49"><a href="#cb1-49"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-50"><a href="#cb1-50"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>  <span class="at">VISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="pkcl02_cache/html/lsting_09c549cb64c8a7719a5c7f2a3d6c97ee">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"VISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"Listing of "</span>, drug_a, <span class="st">" Urine Concentration and Volumes following "</span>, <span class="fu">unique</span>(adpc_x<span class="sc">$</span>REGIMEN)[<span class="dv">1</span>],</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="st">" of "</span>, drug_a, <span class="st">", PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Drug X Urine Concentration and Volumes following BID of Drug X, PK Population
+Protocol: xxnnnnn
+Analyte: Drug X
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                  UR_Conc (ug/mL) -    Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -  
+                                                  Urine Collection    Urine Collection   Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection 
+                                                      Interval:          Interval:       Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):
+Treatment Group        Subject ID         Visit        redose              redose              0 - 4               0 - 4               4 - 8               4 - 8              8 - 12              8 - 12              0 - 24              0 - 24      
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   A: Drug X      AB12345-BRA-1-id-105    Day 1           0                713.94              5.461               96.92               0.562              235.38               0.049              384.98                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                735.22      
+                  AB12345-BRA-1-id-134    Day 1           0               1068.83              4.064               145.1               0.178              352.39               0.006              576.35                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                1080.14     
+                   AB12345-BRA-1-id-42    Day 1           0                817.09              4.277              110.93               0.305              269.39               0.018               440.6                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                737.25      
+                   AB12345-BRA-1-id-93    Day 1           0                864.61              4.324              117.38               0.278              285.06               0.015              466.23                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                757.23      
+                  AB12345-BRA-11-id-217   Day 1           0                724.93              6.225               98.41               0.672              239.01               0.059              390.91                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                1185.46     
+                  AB12345-BRA-11-id-345   Day 1           0                840.09              6.511              114.05               0.588              276.98               0.04               453.01                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                883.89      
+                  AB12345-BRA-11-id-397   Day 1           0                974.41              5.478              132.28               0.354              321.26               0.017              525.44                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                918.67      
+                  AB12345-BRA-11-id-50    Day 1           0                922.97              4.122               125.3               0.228               304.3               0.01                497.7                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                808.08      
+                  AB12345-BRA-13-id-177   Day 1           0                694.09              4.267               94.23               0.421              228.84               0.038              374.28                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                908.45      
+                  AB12345-BRA-14-id-23    Day 1           0                722.84              4.254               98.13               0.386              238.32               0.032              389.78                NA                  NA        
+                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                 862.1      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkcl02_cache/html/sessioninfo_8d07e5e3ab78d6efa1b8d1aaab90ee29">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkcl02_cache/html/snapshot_e65006503cd81a9c7b95358a1a4cea77">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/pharmacokinetic/pkcl02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+        el.classList.add('notransition');
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+      disableStylesheet(alternateStylesheets);
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+          toggle.classList.remove("alternate");
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+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
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+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
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+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
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+            //compute the position of the single el (top and bottom and make a div)
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+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
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+          el,
+          cites: cites.split(' ')
+        };
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+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
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+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/pharmacokinetic/pkcl01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKCL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/pharmacokinetic/pkpl01.html" class="pagination-link">
+        <span class="nav-page-text">PKPL01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> PKCL02</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Drug A Urine Concentration and Volumes</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Drug X"</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>spec <span class="ot">&lt;-</span> <span class="st">"URINE"</span></span>
+<span id="cb9-22"><a href="#cb9-22"></a></span>
+<span id="cb9-23"><a href="#cb9-23"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb9-24"><a href="#cb9-24"></a>adpc_x <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a>  <span class="fu">mutate</span>(<span class="at">REGIMEN =</span> <span class="fu">ifelse</span>(<span class="st">"REGIMEN"</span> <span class="sc">%in%</span> <span class="fu">names</span>(adpc), REGIMEN, <span class="st">"BID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-26"><a href="#cb9-26"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="fu">grepl</span>(drug_a, PARAM),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    ASMED <span class="sc">==</span> spec</span>
+<span id="cb9-29"><a href="#cb9-29"></a>  )</span>
+<span id="cb9-30"><a href="#cb9-30"></a></span>
+<span id="cb9-31"><a href="#cb9-31"></a>out <span class="ot">&lt;-</span> adpc_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_longer</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">cols =</span> <span class="fu">c</span>(AVAL, PCVOL),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">names_to =</span> <span class="st">"URCD"</span>,</span>
+<span id="cb9-35"><a href="#cb9-35"></a>    <span class="at">values_to =</span> <span class="st">"VALUE"</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-38"><a href="#cb9-38"></a>    <span class="at">URCD =</span> <span class="fu">case_when</span>(</span>
+<span id="cb9-39"><a href="#cb9-39"></a>      URCD <span class="sc">==</span> <span class="st">"AVAL"</span> <span class="sc">~</span> <span class="st">"UR_Conc"</span>,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>      URCD <span class="sc">==</span> <span class="st">"PCVOL"</span> <span class="sc">~</span> <span class="st">"Vurine"</span>,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> URCD</span>
+<span id="cb9-42"><a href="#cb9-42"></a>    ),</span>
+<span id="cb9-43"><a href="#cb9-43"></a>    <span class="at">UNIT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb9-44"><a href="#cb9-44"></a>      URCD <span class="sc">==</span> <span class="st">"UR_Conc"</span> <span class="sc">~</span> <span class="fu">as.character</span>(AVALU),</span>
+<span id="cb9-45"><a href="#cb9-45"></a>      URCD <span class="sc">==</span> <span class="st">"Vurine"</span> <span class="sc">~</span> <span class="fu">as.character</span>(PCVOLU),</span>
+<span id="cb9-46"><a href="#cb9-46"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NA"</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a>    )</span>
+<span id="cb9-48"><a href="#cb9-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-49"><a href="#cb9-49"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-50"><a href="#cb9-50"></a>    <span class="at">PARAM_INT =</span> <span class="fu">paste0</span>(</span>
+<span id="cb9-51"><a href="#cb9-51"></a>      URCD, <span class="st">" ("</span>, UNIT, <span class="st">") -</span><span class="sc">\n</span><span class="st">Urine Collection</span><span class="sc">\n</span><span class="st">Interval"</span>,</span>
+<span id="cb9-52"><a href="#cb9-52"></a>      <span class="fu">ifelse</span>(PCTPT <span class="sc">==</span> <span class="st">"Predose"</span>, <span class="st">""</span>, <span class="st">" (hours)"</span>), <span class="st">":</span><span class="sc">\n</span><span class="st">"</span>,</span>
+<span id="cb9-53"><a href="#cb9-53"></a>      <span class="fu">gsub</span>(<span class="st">"[PTH]"</span>, <span class="st">""</span>, PCTPT)</span>
+<span id="cb9-54"><a href="#cb9-54"></a>    )</span>
+<span id="cb9-55"><a href="#cb9-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-56"><a href="#cb9-56"></a>  <span class="fu">select</span>(TRT01A, USUBJID, VISIT, PARAM_INT, VALUE) <span class="sc">%&gt;%</span></span>
+<span id="cb9-57"><a href="#cb9-57"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-58"><a href="#cb9-58"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-59"><a href="#cb9-59"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, VISIT),</span>
+<span id="cb9-60"><a href="#cb9-60"></a>    <span class="at">names_from =</span> PARAM_INT,</span>
+<span id="cb9-61"><a href="#cb9-61"></a>    <span class="at">values_from =</span> VALUE</span>
+<span id="cb9-62"><a href="#cb9-62"></a>  )</span>
+<span id="cb9-63"><a href="#cb9-63"></a></span>
+<span id="cb9-64"><a href="#cb9-64"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-65"><a href="#cb9-65"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb9-66"><a href="#cb9-66"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb9-67"><a href="#cb9-67"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb9-68"><a href="#cb9-68"></a>  <span class="at">VISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb9-69"><a href="#cb9-69"></a>)</span>
+<span id="cb9-70"><a href="#cb9-70"></a><span class="in">```</span></span>
+<span id="cb9-71"><a href="#cb9-71"></a></span>
+<span id="cb9-72"><a href="#cb9-72"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-73"><a href="#cb9-73"></a></span>
+<span id="cb9-74"><a href="#cb9-74"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-75"><a href="#cb9-75"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-76"><a href="#cb9-76"></a>  out,</span>
+<span id="cb9-77"><a href="#cb9-77"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"VISIT"</span>),</span>
+<span id="cb9-78"><a href="#cb9-78"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-79"><a href="#cb9-79"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb9-80"><a href="#cb9-80"></a>    <span class="st">"Listing of "</span>, drug_a, <span class="st">" Urine Concentration and Volumes following "</span>, <span class="fu">unique</span>(adpc_x<span class="sc">$</span>REGIMEN)[<span class="dv">1</span>],</span>
+<span id="cb9-81"><a href="#cb9-81"></a>    <span class="st">" of "</span>, drug_a, <span class="st">", PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span></span>
+<span id="cb9-82"><a href="#cb9-82"></a>  ),</span>
+<span id="cb9-83"><a href="#cb9-83"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb9-84"><a href="#cb9-84"></a>)</span>
+<span id="cb9-85"><a href="#cb9-85"></a></span>
+<span id="cb9-86"><a href="#cb9-86"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-87"><a href="#cb9-87"></a><span class="in">```</span></span>
+<span id="cb9-88"><a href="#cb9-88"></a></span>
+<span id="cb9-89"><a href="#cb9-89"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-90"><a href="#cb9-90"></a></span>
+<span id="cb9-91"><a href="#cb9-91"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-92"><a href="#cb9-92"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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--- /dev/null
+++ b/stable/listings/pharmacokinetic/pkpl01.html
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+ <span class="menu-text">AET03</span></a>
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+ <span class="menu-text">AET04</span></a>
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+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET09</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+  <div class="sidebar-item-container"> 
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+ <span class="menu-text">DTHT01</span></a>
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+ <span class="menu-text">DMT01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+ <span class="menu-text">DISCLOSUREST01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Drug A Plasma PK Parameters</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpl01_cache/html/setup_358731088a34a6532a96fe93da246abf">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>spec <span class="ot">&lt;-</span> <span class="st">"Plasma"</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  PPCAT <span class="sc">==</span> drug_a,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  PPSPEC <span class="sc">==</span> spec</span>
+<span id="cb1-12"><a href="#cb1-12"></a>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>out <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">select</span>(TRT01A, USUBJID, AVISIT, PARAM, AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, AVISIT),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  )</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="pkpl01_cache/html/lsting_73fa0c88247358fca48118c94bdabe8e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, drug_a, spec, <span class="st">"PK Parameters, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Plasma Drug X Plasma PK Parameters, PK Population
+Protocol: xxnnnnn
+Analyte: Plasma Drug X
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Group        Subject ID             Visit       AUC Infinity Obs (day*ug/mL)   Max Conc (ug/mL)   Total CL Obs (ml/day/kg)
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   A: Drug X      AB12345-BRA-1-id-105      SCREENING           145.191684898102         35.5067335878638       5.1567601025515     
+                                          CYCLE 1 DAY 1         246.349321001289         31.2264481880236       4.41386730113941    
+                                          CYCLE 1 DAY 2         225.443483077171         43.4987268488453       4.81490455551286    
+                  AB12345-BRA-1-id-134      SCREENING           157.461703380688         32.1171292884992       6.0374125711965     
+                                          CYCLE 1 DAY 1         248.519038520728         21.7795763901966        4.561839813278     
+                                          CYCLE 1 DAY 2         230.794839837734         21.0627132276049       6.95200595313275    
+                   AB12345-BRA-1-id-42      SCREENING           194.224015921831         20.4565798423567       6.33709739029277    
+                                          CYCLE 1 DAY 1         210.528307366678         26.7845825535397       3.50776680376268    
+                                          CYCLE 1 DAY 2         167.592869235882         34.8276545020143       4.11969088323673    
+                   AB12345-BRA-1-id-93      SCREENING           186.75868084484          27.3983170052516       3.40495133575408    
+                                          CYCLE 1 DAY 1         160.406798051843         17.5296885232566       3.8508725098954     
+                                          CYCLE 1 DAY 2         252.04512291352          32.4903879259459       6.21586252565961    
+                  AB12345-BRA-11-id-217     SCREENING           215.367414313054         20.8879942219526       6.55883385955605    
+                                          CYCLE 1 DAY 1         272.094354596647         34.2812274648873       5.04441608634882    
+                                          CYCLE 1 DAY 2         174.183265394136          23.04243406023        4.07416508597243    
+                  AB12345-BRA-11-id-345     SCREENING           235.746948097021         26.5740342881269       5.52059967823211    
+                                          CYCLE 1 DAY 1         228.51025073098          39.7523164840323       6.32996327499752    
+                                          CYCLE 1 DAY 2         120.712762389698          24.37143486359        5.02620823564574    
+                  AB12345-BRA-11-id-397     SCREENING           165.925716319045         21.8770819414152       6.3713157196375     
+                                          CYCLE 1 DAY 1         201.536920713046         36.5841424116449       4.32440907316618    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpl01_cache/html/sessioninfo_d00b973c6c35c594e2af45e70f33398b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpl01_cache/html/snapshot_86a4ee4c8a69533924d972e1c734928a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/pharmacokinetic/pkpl01.lock">Download</a></p>
+</section>
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+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
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+        button.removeAttribute("data-bs-placement");
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+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
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+          details.removeAttribute("open");
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+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
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+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
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+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
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+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
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+        let top = null;
+        let height = null;
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+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
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+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
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+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
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+          el,
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/pharmacokinetic/pkcl02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKCL02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/pharmacokinetic/pkpl02.html" class="pagination-link">
+        <span class="nav-page-text">PKPL02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> PKPL01</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Drug A Plasma PK Parameters</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>spec <span class="ot">&lt;-</span> <span class="st">"Plasma"</span></span>
+<span id="cb9-22"><a href="#cb9-22"></a></span>
+<span id="cb9-23"><a href="#cb9-23"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb9-24"><a href="#cb9-24"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>  PPCAT <span class="sc">==</span> drug_a,</span>
+<span id="cb9-26"><a href="#cb9-26"></a>  PPSPEC <span class="sc">==</span> spec</span>
+<span id="cb9-27"><a href="#cb9-27"></a>)</span>
+<span id="cb9-28"><a href="#cb9-28"></a></span>
+<span id="cb9-29"><a href="#cb9-29"></a>out <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>  <span class="fu">select</span>(TRT01A, USUBJID, AVISIT, PARAM, AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, AVISIT),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb9-35"><a href="#cb9-35"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb9-36"><a href="#cb9-36"></a>  )</span>
+<span id="cb9-37"><a href="#cb9-37"></a></span>
+<span id="cb9-38"><a href="#cb9-38"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-39"><a href="#cb9-39"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb9-40"><a href="#cb9-40"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb9-43"><a href="#cb9-43"></a>)</span>
+<span id="cb9-44"><a href="#cb9-44"></a><span class="in">```</span></span>
+<span id="cb9-45"><a href="#cb9-45"></a></span>
+<span id="cb9-46"><a href="#cb9-46"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-47"><a href="#cb9-47"></a></span>
+<span id="cb9-48"><a href="#cb9-48"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-49"><a href="#cb9-49"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-50"><a href="#cb9-50"></a>  out,</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb9-52"><a href="#cb9-52"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-53"><a href="#cb9-53"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, drug_a, spec, <span class="st">"PK Parameters, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb9-54"><a href="#cb9-54"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb9-55"><a href="#cb9-55"></a>)</span>
+<span id="cb9-56"><a href="#cb9-56"></a></span>
+<span id="cb9-57"><a href="#cb9-57"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-58"><a href="#cb9-58"></a><span class="in">```</span></span>
+<span id="cb9-59"><a href="#cb9-59"></a></span>
+<span id="cb9-60"><a href="#cb9-60"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-61"><a href="#cb9-61"></a></span>
+<span id="cb9-62"><a href="#cb9-62"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-63"><a href="#cb9-63"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/listings/pharmacokinetic/pkpl02.html b/stable/listings/pharmacokinetic/pkpl02.html
new file mode 100644
index 0000000000..ccff53ba1d
--- /dev/null
+++ b/stable/listings/pharmacokinetic/pkpl02.html
@@ -0,0 +1,2076 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - PKPL02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../listings/pharmacokinetic/pkpl04.html" rel="next">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPL02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Drug A Urine PK Parameters</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpl02_cache/html/setup_d2e679ee1ed9b02ed7643f6a89e4f2aa">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>spec <span class="ot">&lt;-</span> <span class="st">"Urine"</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  PPCAT <span class="sc">==</span> drug_a,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  PPSPEC <span class="sc">==</span> spec</span>
+<span id="cb1-12"><a href="#cb1-12"></a>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>out <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">select</span>(TRT01A, USUBJID, AVISIT, PARAM, AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, AVISIT),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  )</span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-25"><a href="#cb1-25"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="pkpl02_cache/html/lsting_366632d571ea89f968203f1ab3d64ef3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, drug_a, spec, <span class="st">"PK Parameters, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Plasma Drug X Urine PK Parameters, PK Population
+Protocol: xxnnnnn
+Analyte: Plasma Drug X
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Group        Subject ID             Visit        Renal CL (L/hr)     Renal CL Norm by Dose (L/hr/mg)   Amt Rec from T1 to T2 (mg)   Pct Rec from T1 to T2 (%)
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+   A: Drug X      AB12345-BRA-1-id-105      SCREENING     0.0538423152160391         0.00441769893771616              2.15210785813109            17.8220657702531     
+                                          CYCLE 1 DAY 1   0.0480828455497337         0.00418360874479016              1.77968465488986            13.4821873677008     
+                                          CYCLE 1 DAY 2   0.0524191320174391         0.00574562025709617              1.7751362634173             11.7748899262287     
+                  AB12345-BRA-1-id-134      SCREENING     0.054828756388858          0.00489378524965625              1.69069405572207            14.6782255303037     
+                                          CYCLE 1 DAY 1   0.0463628883891636         0.00281388401660215              1.03364773182262            15.2049132671477     
+                                          CYCLE 1 DAY 2   0.0542853013687975         0.00480239019141706              2.07978470495693            16.6499332185177     
+                   AB12345-BRA-1-id-42      SCREENING     0.0479776607513692         0.00620670551445586              1.49259200502984            12.4632371401908     
+                                          CYCLE 1 DAY 1   0.060136833920038          0.00423749524975822               2.002399829348             16.1228873656652     
+                                          CYCLE 1 DAY 2   0.0222050225259149         0.0041513339034891               1.65173021070619             10.129985981426     
+                   AB12345-BRA-1-id-93      SCREENING     0.0429283028076499         0.00450841008626937             0.882348047230192            19.8088728992851     
+                                          CYCLE 1 DAY 1   0.0343747382858835         0.00495342578722049              1.73500915591676            14.8733500411057     
+                                          CYCLE 1 DAY 2   0.0474831008867497         0.00415970555107753              1.30298887256052            14.9616973312841     
+                  AB12345-BRA-11-id-217     SCREENING     0.0524432563610182         0.00439177770746837              1.16344390767412             16.584779611686     
+                                          CYCLE 1 DAY 1   0.0411628011374518         0.00567801310981526              1.11763922430636            19.3000982041101     
+                                          CYCLE 1 DAY 2   0.0672581292323284         0.00400060865194939              1.45655867480937            10.1596117673893     
+                  AB12345-BRA-11-id-345     SCREENING     0.044070189259969          0.00561835429596993              1.43739076299198            15.4875095868721     
+                                          CYCLE 1 DAY 1   0.0362275034574886         0.0038765297501434                0.96604915921              17.1567306808389     
+                                          CYCLE 1 DAY 2   0.0416331541840018         0.00462187415243145              1.27070193721417            19.2547757988484     
+                  AB12345-BRA-11-id-397     SCREENING     0.0379747899730378         0.0047876948377162               1.67729762147252            11.6015615292251     
+                                          CYCLE 1 DAY 1   0.0430467407701829         0.00463308440642305              1.1695965192594             12.5511219923965     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpl02_cache/html/sessioninfo_5ca38107503dd8e9768dcc5e90bf617f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpl02_cache/html/snapshot_65c28e3d07e053af7ec461b15caf1a3c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/pharmacokinetic/pkpl02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
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+            if (gutterDiv === null) {
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+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
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+          selectedAnnoteEl = annoteEl;
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+      };
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+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
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+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
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+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/pharmacokinetic/pkpl01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPL01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/pharmacokinetic/pkpl04.html" class="pagination-link">
+        <span class="nav-page-text">PKPL04</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> PKPL02</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Drug A Urine PK Parameters</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>spec <span class="ot">&lt;-</span> <span class="st">"Urine"</span></span>
+<span id="cb9-22"><a href="#cb9-22"></a></span>
+<span id="cb9-23"><a href="#cb9-23"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb9-24"><a href="#cb9-24"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(</span>
+<span id="cb9-25"><a href="#cb9-25"></a>  PPCAT <span class="sc">==</span> drug_a,</span>
+<span id="cb9-26"><a href="#cb9-26"></a>  PPSPEC <span class="sc">==</span> spec</span>
+<span id="cb9-27"><a href="#cb9-27"></a>)</span>
+<span id="cb9-28"><a href="#cb9-28"></a></span>
+<span id="cb9-29"><a href="#cb9-29"></a>out <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a>  <span class="fu">select</span>(TRT01A, USUBJID, AVISIT, PARAM, AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb9-33"><a href="#cb9-33"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(TRT01A, USUBJID, AVISIT),</span>
+<span id="cb9-35"><a href="#cb9-35"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb9-36"><a href="#cb9-36"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb9-37"><a href="#cb9-37"></a>  )</span>
+<span id="cb9-38"><a href="#cb9-38"></a></span>
+<span id="cb9-39"><a href="#cb9-39"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-40"><a href="#cb9-40"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="at">TRT01A =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb9-42"><a href="#cb9-42"></a>  <span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>,</span>
+<span id="cb9-43"><a href="#cb9-43"></a>  <span class="at">AVISIT =</span> <span class="st">"Visit"</span></span>
+<span id="cb9-44"><a href="#cb9-44"></a>)</span>
+<span id="cb9-45"><a href="#cb9-45"></a><span class="in">```</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a></span>
+<span id="cb9-47"><a href="#cb9-47"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb9-48"><a href="#cb9-48"></a></span>
+<span id="cb9-49"><a href="#cb9-49"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-50"><a href="#cb9-50"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  out,</span>
+<span id="cb9-52"><a href="#cb9-52"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"TRT01A"</span>, <span class="st">"USUBJID"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb9-53"><a href="#cb9-53"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-54"><a href="#cb9-54"></a>  <span class="at">main_title =</span> <span class="fu">paste</span>(<span class="st">"Listing of"</span>, drug_a, spec, <span class="st">"PK Parameters, PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>),</span>
+<span id="cb9-55"><a href="#cb9-55"></a>  <span class="at">subtitles =</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, drug_a)</span>
+<span id="cb9-56"><a href="#cb9-56"></a>)</span>
+<span id="cb9-57"><a href="#cb9-57"></a></span>
+<span id="cb9-58"><a href="#cb9-58"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-59"><a href="#cb9-59"></a><span class="in">```</span></span>
+<span id="cb9-60"><a href="#cb9-60"></a></span>
+<span id="cb9-61"><a href="#cb9-61"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-62"><a href="#cb9-62"></a></span>
+<span id="cb9-63"><a href="#cb9-63"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-64"><a href="#cb9-64"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/listings/pharmacokinetic/pkpl04.html b/stable/listings/pharmacokinetic/pkpl04.html
new file mode 100644
index 0000000000..ecd0dda80c
--- /dev/null
+++ b/stable/listings/pharmacokinetic/pkpl04.html
@@ -0,0 +1,2109 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+ul.task-list{list-style: none;}
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
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+div.sourceCode { overflow: auto; }
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+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+  { counter-reset: source-line 0; }
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+  { position: relative; left: -4em; counter-increment: source-line; }
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+div.sourceCode
+  {   }
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+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPL04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Individual Drug A AUCIFO and CMAX Ratios Following Drug A or Drug B</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing - CYCLE 1 DAY 1</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpl04_cache/html/setup_bd7c61c0eb618aba1a1691f53d2eae1b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>visit <span class="ot">&lt;-</span> <span class="st">"CYCLE 1 DAY 1"</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span> <span class="co"># numerator drug</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>drug_b <span class="ot">&lt;-</span> <span class="st">"Plasma Drug Y"</span> <span class="co"># denominator drug</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    AVISIT <span class="sc">==</span> visit,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(drug_a, drug_b),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CMAX"</span>, <span class="st">"AUCIFO"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  )</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>adpp_ratio <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, PARAM_U),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  )</span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a>adpp_ratio[, <span class="fu">paste0</span>(drug_a, <span class="st">"/"</span>, drug_b)] <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">unlist</span>(adpp_ratio[, drug_a] <span class="sc">/</span> adpp_ratio[, drug_b]))</span>
+<span id="cb1-29"><a href="#cb1-29"></a></span>
+<span id="cb1-30"><a href="#cb1-30"></a>out <span class="ot">&lt;-</span> adpp_ratio <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">id_cols =</span> USUBJID,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">names_glue =</span> <span class="st">"{PARAM_U}</span><span class="sc">\n</span><span class="st">{.value}"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(<span class="fu">all_of</span>(drug_a), <span class="fu">all_of</span>(drug_b), <span class="fu">paste0</span>(drug_a, <span class="st">"/"</span>, drug_b))</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="fu">select</span>(<span class="fu">names</span>(.)[<span class="fu">c</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, <span class="dv">4</span>, <span class="dv">6</span>, <span class="dv">3</span>, <span class="dv">5</span>, <span class="dv">7</span>)])</span>
+<span id="cb1-38"><a href="#cb1-38"></a></span>
+<span id="cb1-39"><a href="#cb1-39"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb1-40"><a href="#cb1-40"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(<span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="pkpl04_cache/html/lsting_577c2b20acd8395e721c15de03171f12">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"Listing of Individual "</span>, drug_a, <span class="st">" "</span>, <span class="fu">paste</span>(<span class="fu">unique</span>(adpp_x<span class="sc">$</span>PARAM), <span class="at">collapse =</span> <span class="st">" and "</span>), <span class="st">" Ratios following "</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="fu">unique</span>(adpp_x<span class="sc">$</span>REGIMEN), <span class="st">" "</span>, <span class="fu">paste</span>(drug_a, drug_b, <span class="at">sep =</span> <span class="st">" or "</span>), <span class="st">", PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">unique</span>(adpp_x<span class="sc">$</span>AVISIT)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">subtitles =</span> <span class="fu">paste0</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Analytes: "</span>, <span class="fu">paste</span>(drug_a, drug_b, <span class="at">sep =</span> <span class="st">" and "</span>))</span>
+<span id="cb2-11"><a href="#cb2-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>sorting incoming data by key columns</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Individual Plasma Drug X AUC Infinity Obs and Max Conc Ratios following BID Plasma Drug X or Plasma Drug Y, PK Population
+Protocol: xxnnnnn
+Visit: CYCLE 1 DAY 1
+
+Analytes: Plasma Drug X and Plasma Drug Y
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                        AUC Infinity Obs (day*ug/mL)   AUC Infinity Obs (day*ug/mL)   AUC Infinity Obs (day*ug/mL)   Max Conc (ug/mL)   Max Conc (ug/mL)        Max Conc (ug/mL)      
+     Subject ID                Plasma Drug X                  Plasma Drug Y           Plasma Drug X/Plasma Drug Y     Plasma Drug X      Plasma Drug Y     Plasma Drug X/Plasma Drug Y
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+AB12345-BRA-1-id-105          246.349321001289                      NA                             NA                31.2264481880236          NA                      NA             
+AB12345-BRA-1-id-134          248.519038520728                      NA                             NA                21.7795763901966          NA                      NA             
+AB12345-BRA-1-id-141          204.038850147211               191.797779791421               1.06382279486812         29.5409649407056   38.8911230490524        0.759581174949522     
+AB12345-BRA-1-id-265          196.360864588266               218.652833415662              0.898048570973609         35.6328283094637   34.2215467219396        1.04123956170044      
+ AB12345-BRA-1-id-42          210.528307366678                      NA                             NA                26.7845825535397          NA                      NA             
+ AB12345-BRA-1-id-93          160.406798051843                      NA                             NA                17.5296885232566          NA                      NA             
+AB12345-BRA-11-id-171         217.543269983548               180.798322952882               1.20323721166508         30.3782220474834   31.615072576154         0.960877820992148     
+AB12345-BRA-11-id-217         272.094354596647                      NA                             NA                34.2812274648873          NA                      NA             
+AB12345-BRA-11-id-237         148.094218281784               193.694022424355              0.764578154907287         32.9103242471385   38.7385450224575        0.849549827647366     
+AB12345-BRA-11-id-321         206.178847103577               216.464946980475               0.95248145244585         33.0064256549217   28.4783979285037         1.1589986816599      
+AB12345-BRA-11-id-345         228.51025073098                       NA                             NA                39.7523164840323          NA                      NA             
+AB12345-BRA-11-id-397         201.536920713046                      NA                             NA                36.5841424116449          NA                      NA             
+AB12345-BRA-11-id-50          189.012389008811                      NA                             NA                21.1977400008473          NA                      NA             
+ AB12345-BRA-11-id-9          235.477941027941               207.851453783084               1.13291457308587         27.1559637630099   28.2923295654501        0.959834844995305     
+AB12345-BRA-13-id-177         185.956676853099                      NA                             NA                31.0405525087113          NA                      NA             
+AB12345-BRA-14-id-120         209.878908685802               301.584778421544              0.695920098435608         31.8076450080362   22.9229189133965        1.38759139393227      
+AB12345-BRA-14-id-23          270.799396057463                      NA                             NA                29.2804222629517          NA                      NA             
+AB12345-BRA-15-id-36          183.877364155027                      NA                             NA                37.9405096212457          NA                      NA             
+AB12345-BRA-2-id-296          216.092875093089                      NA                             NA                27.3509307000219          NA                      NA             
+AB12345-BRA-4-id-368          203.23438144437                149.30280248041                1.36122281744199         38.3952821076341   30.8121148640987        1.24610992387189      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpl04_cache/html/sessioninfo_5a1483999894f8d4503998aa0df83658">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpl04_cache/html/snapshot_e0c327bf278c4b30af5690ffa1b0ca79">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/pharmacokinetic/pkpl04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
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+  }
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/pharmacokinetic/pkpl02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPL02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../listings/vital-signs/vsl01.html" class="pagination-link">
+        <span class="nav-page-text">VSL01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb9" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb9-1"><a href="#cb9-1"></a><span class="co">---</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="an">title:</span><span class="co"> PKPL04</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="an">subtitle:</span><span class="co"> Listing of Individual Drug A AUCIFO and CMAX Ratios Following Drug A or Drug B</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="co">---</span></span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>------------------------------------------------------------------------</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb9-9"><a href="#cb9-9"></a></span>
+<span id="cb9-10"><a href="#cb9-10"></a>::: panel-tabset</span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a></span>
+<span id="cb9-16"><a href="#cb9-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-17"><a href="#cb9-17"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb9-18"><a href="#cb9-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb9-21"><a href="#cb9-21"></a></span>
+<span id="cb9-22"><a href="#cb9-22"></a>visit <span class="ot">&lt;-</span> <span class="st">"CYCLE 1 DAY 1"</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a>drug_a <span class="ot">&lt;-</span> <span class="st">"Plasma Drug X"</span> <span class="co"># numerator drug</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a>drug_b <span class="ot">&lt;-</span> <span class="st">"Plasma Drug Y"</span> <span class="co"># denominator drug</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a></span>
+<span id="cb9-26"><a href="#cb9-26"></a>adpp_x <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb9-27"><a href="#cb9-27"></a>  <span class="fu">filter</span>(</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    AVISIT <span class="sc">==</span> visit,</span>
+<span id="cb9-29"><a href="#cb9-29"></a>    PPCAT <span class="sc">%in%</span> <span class="fu">c</span>(drug_a, drug_b),</span>
+<span id="cb9-30"><a href="#cb9-30"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CMAX"</span>, <span class="st">"AUCIFO"</span>)</span>
+<span id="cb9-31"><a href="#cb9-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-32"><a href="#cb9-32"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">PARAM_U =</span> <span class="fu">paste0</span>(PARAM, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>)</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  )</span>
+<span id="cb9-35"><a href="#cb9-35"></a></span>
+<span id="cb9-36"><a href="#cb9-36"></a>adpp_ratio <span class="ot">&lt;-</span> adpp_x <span class="sc">%&gt;%</span></span>
+<span id="cb9-37"><a href="#cb9-37"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-38"><a href="#cb9-38"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(USUBJID, PARAM_U),</span>
+<span id="cb9-39"><a href="#cb9-39"></a>    <span class="at">names_from =</span> PPCAT,</span>
+<span id="cb9-40"><a href="#cb9-40"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb9-41"><a href="#cb9-41"></a>  )</span>
+<span id="cb9-42"><a href="#cb9-42"></a></span>
+<span id="cb9-43"><a href="#cb9-43"></a>adpp_ratio[, <span class="fu">paste0</span>(drug_a, <span class="st">"/"</span>, drug_b)] <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">unlist</span>(adpp_ratio[, drug_a] <span class="sc">/</span> adpp_ratio[, drug_b]))</span>
+<span id="cb9-44"><a href="#cb9-44"></a></span>
+<span id="cb9-45"><a href="#cb9-45"></a>out <span class="ot">&lt;-</span> adpp_ratio <span class="sc">%&gt;%</span></span>
+<span id="cb9-46"><a href="#cb9-46"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb9-47"><a href="#cb9-47"></a>    <span class="at">id_cols =</span> USUBJID,</span>
+<span id="cb9-48"><a href="#cb9-48"></a>    <span class="at">names_from =</span> PARAM_U,</span>
+<span id="cb9-49"><a href="#cb9-49"></a>    <span class="at">names_glue =</span> <span class="st">"{PARAM_U}</span><span class="sc">\n</span><span class="st">{.value}"</span>,</span>
+<span id="cb9-50"><a href="#cb9-50"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(<span class="fu">all_of</span>(drug_a), <span class="fu">all_of</span>(drug_b), <span class="fu">paste0</span>(drug_a, <span class="st">"/"</span>, drug_b))</span>
+<span id="cb9-51"><a href="#cb9-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-52"><a href="#cb9-52"></a>  <span class="fu">select</span>(<span class="fu">names</span>(.)[<span class="fu">c</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, <span class="dv">4</span>, <span class="dv">6</span>, <span class="dv">3</span>, <span class="dv">5</span>, <span class="dv">7</span>)])</span>
+<span id="cb9-53"><a href="#cb9-53"></a></span>
+<span id="cb9-54"><a href="#cb9-54"></a><span class="fu">var_labels</span>(out) <span class="ot">&lt;-</span> <span class="fu">names</span>(out)</span>
+<span id="cb9-55"><a href="#cb9-55"></a>out <span class="ot">&lt;-</span> out <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(<span class="at">USUBJID =</span> <span class="st">"Subject ID"</span>)</span>
+<span id="cb9-56"><a href="#cb9-56"></a><span class="in">```</span></span>
+<span id="cb9-57"><a href="#cb9-57"></a></span>
+<span id="cb9-58"><a href="#cb9-58"></a><span class="fu">## Standard Listing - CYCLE 1 DAY 1</span></span>
+<span id="cb9-59"><a href="#cb9-59"></a></span>
+<span id="cb9-60"><a href="#cb9-60"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb9-61"><a href="#cb9-61"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb9-62"><a href="#cb9-62"></a>  out,</span>
+<span id="cb9-63"><a href="#cb9-63"></a>  <span class="at">key_cols =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb9-64"><a href="#cb9-64"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb9-65"><a href="#cb9-65"></a>  <span class="at">main_title =</span> <span class="fu">paste0</span>(</span>
+<span id="cb9-66"><a href="#cb9-66"></a>    <span class="st">"Listing of Individual "</span>, drug_a, <span class="st">" "</span>, <span class="fu">paste</span>(<span class="fu">unique</span>(adpp_x<span class="sc">$</span>PARAM), <span class="at">collapse =</span> <span class="st">" and "</span>), <span class="st">" Ratios following "</span>,</span>
+<span id="cb9-67"><a href="#cb9-67"></a>    <span class="fu">unique</span>(adpp_x<span class="sc">$</span>REGIMEN), <span class="st">" "</span>, <span class="fu">paste</span>(drug_a, drug_b, <span class="at">sep =</span> <span class="st">" or "</span>), <span class="st">", PK Population</span><span class="sc">\n</span><span class="st">Protocol: xxnnnnn"</span>,</span>
+<span id="cb9-68"><a href="#cb9-68"></a>    <span class="st">"</span><span class="sc">\n</span><span class="st">Visit: "</span>, <span class="fu">unique</span>(adpp_x<span class="sc">$</span>AVISIT)</span>
+<span id="cb9-69"><a href="#cb9-69"></a>  ),</span>
+<span id="cb9-70"><a href="#cb9-70"></a>  <span class="at">subtitles =</span> <span class="fu">paste0</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Analytes: "</span>, <span class="fu">paste</span>(drug_a, drug_b, <span class="at">sep =</span> <span class="st">" and "</span>))</span>
+<span id="cb9-71"><a href="#cb9-71"></a>)</span>
+<span id="cb9-72"><a href="#cb9-72"></a></span>
+<span id="cb9-73"><a href="#cb9-73"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb9-74"><a href="#cb9-74"></a><span class="in">```</span></span>
+<span id="cb9-75"><a href="#cb9-75"></a></span>
+<span id="cb9-76"><a href="#cb9-76"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb9-77"><a href="#cb9-77"></a></span>
+<span id="cb9-78"><a href="#cb9-78"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb9-79"><a href="#cb9-79"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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new file mode 100644
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@@ -0,0 +1,2149 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
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+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
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+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
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+div.sourceCode { overflow: auto; }
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+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
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+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+ <span class="menu-text">AET06</span></a>
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+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET07</span></a>
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+ <span class="menu-text">ECG</span></a>
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+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="true">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">VSL01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Listing of Vital Signs: Safety-Evaluable Patients</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Listing</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="vsl01_cache/html/setup_bb716f9fe7551b3306ca5aa3a6512892">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>get_param_unit_range <span class="ot">&lt;-</span> <span class="cf">function</span>(dataset) {</span>
+<span id="cb1-8"><a href="#cb1-8"></a>  u_rng <span class="ot">&lt;-</span> <span class="fu">lapply</span>(<span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD), <span class="cf">function</span>(p) {</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    dat <span class="ot">&lt;-</span> dataset <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> p)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="fu">list</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>      <span class="at">unit =</span> <span class="fu">unique</span>(dat<span class="sc">$</span>AVALU),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>      <span class="at">range =</span> <span class="fu">paste0</span>(<span class="fu">unique</span>(dat<span class="sc">$</span>ANRLO), <span class="st">"-"</span>, <span class="fu">unique</span>(dat<span class="sc">$</span>ANRHI))</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    )</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  })</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">names</span>(u_rng) <span class="ot">&lt;-</span> <span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  u_rng</span>
+<span id="cb1-17"><a href="#cb1-17"></a>}</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>vs_u_rng <span class="ot">&lt;-</span> <span class="fu">get_param_unit_range</span>(advs)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>advs_sub <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(VSSEQ)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, <span class="fu">sub</span>(<span class="st">"^.*-([[:alnum:]]+)$"</span>, <span class="st">"</span><span class="sc">\\</span><span class="st">1"</span>, SUBJID), <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">AVAL_ANRIND =</span> <span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">""</span>), AVAL, <span class="fu">paste</span>(AVAL, <span class="fu">substr</span>(ANRIND, <span class="dv">1</span>, <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">"/"</span>)),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">CHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(CHG, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>)</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  )</span>
+<span id="cb1-30"><a href="#cb1-30"></a></span>
+<span id="cb1-31"><a href="#cb1-31"></a>anl_vs <span class="ot">&lt;-</span> advs_sub <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">select</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(AVAL_ANRIND, CHG)</span>
+<span id="cb1-37"><a href="#cb1-37"></a>  )</span>
+<span id="cb1-38"><a href="#cb1-38"></a></span>
+<span id="cb1-39"><a href="#cb1-39"></a>out <span class="ot">&lt;-</span> anl_vs <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">select</span>(</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_WEIGHT, CHG_WEIGHT, AVAL_ANRIND_TEMP, CHG_TEMP, AVAL_ANRIND_DIABP,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    CHG_DIABP, AVAL_ANRIND_SYSBP, CHG_SYSBP, AVAL_ANRIND_PULSE, CHG_PULSE, AVAL_ANRIND_RESP, CHG_RESP</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">AVAL_ANRIND_WEIGHT =</span> <span class="fu">paste0</span>(<span class="st">"Weight</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>WEIGHT<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>WEIGHT<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    <span class="at">CHG_WEIGHT =</span> <span class="st">"Weight</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">AVAL_ANRIND_TEMP =</span> <span class="fu">paste0</span>(<span class="st">"Temperature Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>TEMP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>TEMP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    <span class="at">CHG_TEMP =</span> <span class="st">"Temperature Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    <span class="at">AVAL_ANRIND_DIABP =</span> <span class="fu">paste0</span>(<span class="st">"Diastolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>DIABP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>DIABP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    <span class="at">CHG_DIABP =</span> <span class="st">"Diastolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>    <span class="at">AVAL_ANRIND_SYSBP =</span> <span class="fu">paste0</span>(<span class="st">"Systolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>SYSBP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>SYSBP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-57"><a href="#cb1-57"></a>    <span class="at">CHG_SYSBP =</span> <span class="st">"Systolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    <span class="at">AVAL_ANRIND_PULSE =</span> <span class="fu">paste0</span>(<span class="st">"Pulse Rate Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>PULSE<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>PULSE<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="at">CHG_PULSE =</span> <span class="st">"Pulse Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="at">AVAL_ANRIND_RESP =</span> <span class="fu">paste0</span>(<span class="st">"Respiratory Rate</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>RESP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>RESP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb1-61"><a href="#cb1-61"></a>    <span class="at">CHG_RESP =</span> <span class="st">"Respiratory Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;lsting&quot;:&quot;lsting&quot;}" data-hash="vsl01_cache/html/lsting_96148642f6f7a3be03df0b829ce360f0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  out,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Vital Signs: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">main_footer =</span> <span class="st">"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a><span class="st">  outside the Roche standard reference range."</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a></span>
+<span id="cb2-10"><a href="#cb2-10"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Listing of Vital Signs: Safety-Evaluable Patients
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                                                                                                                                        Diastolic Blood                                                                                                                                
+                                                                                                                                                                           Pressure,                        Systolic Blood                                                                                             
+                                                                                                  Weight                                                                    Sitting       Diastolic Blood      Pressure,      Systolic Blood                                        Respiratory Rate                   
+                                                                                                  Result                        Temperature Result                          Result           Pressure,          Sitting         Pressure,      Pulse Rate Result                         Result                        
+                                                                                      Study       (Kg);            Weight              (C);          Temperature Rate        (Pa);            Sitting            (Pa);           Sitting         (beats/min);        Pulse Rate      (breaths/min);    Respiratory Rate
+Center/Subject ID            Age/Sex/Race              Treatment          Visit        Day    Range:(40-100)   Change from BL   Range:(36.1-37.2)     Change from BL    Range:(80-120)    Change from BL    Range:(120-180)   Change from BL    Range:(60-100)     Change from BL    Range:(12-20)      Change from BL 
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+    BRA-1/105       38/M/BLACK OR AFRICAN AMERICAN     A: Drug X      WEEK 1 DAY 8     189        90.96            24.62              36.79               -1.88             101.10            -12.65           181.05/H            3.70              84.91             -2.05             18.34               1.13      
+                                                                      WEEK 2 DAY 15    323        41.40            -24.93             36.52               -2.14             111.02             -2.72            132.47            -44.88             71.54             -15.42            9.81/L             -7.40      
+                                                                      WEEK 3 DAY 22    492        60.55            -5.78             35.03/L              -3.64              88.35            -25.39           112.67/L           -64.68            33.75/L            -53.22           21.23/H              4.02      
+                                                                      WEEK 4 DAY 29    550        69.69             3.36             35.71/L              -2.95             100.74            -13.00           194.88/H           17.53              97.51             10.54             12.50              -4.71      
+                                                                      WEEK 5 DAY 36    628        81.64            15.30             36.01/L              -2.65            123.17/H            9.43             140.33            -37.02             62.50             -24.47           10.91/L             -6.30      
+    BRA-1/134                 47/M/WHITE               A: Drug X      WEEK 1 DAY 8     203        42.95            -12.51             36.39               -1.38             112.71             26.38            148.69            -52.75             69.12              3.72             15.31              -2.84      
+                                                                      WEEK 2 DAY 15    326       20.36/L           -35.09            35.75/L              -2.03              98.42             12.09           188.08/H           -13.36             68.79              3.40             17.60              -0.55      
+                                                                      WEEK 3 DAY 22    363        46.33            -9.12             35.43/L              -2.34              97.88             11.55            160.05            -41.39             90.21             24.81             18.15               0.00      
+                                                                      WEEK 4 DAY 29    367        43.83            -11.62            36.01/L              -1.76              98.97             12.65            132.19            -69.25             88.39             23.00             19.62               1.48      
+                                                                      WEEK 5 DAY 36    417       31.75/L           -23.71             36.35               -1.42            124.26/H            37.94            134.30            -67.14             88.64             23.25            20.08/H              1.94      
+    BRA-1/141                 35/F/WHITE             C: Combination   WEEK 1 DAY 8     515        65.32             9.22              36.72               -0.29              81.16            -48.30            73.44/L           -63.33             99.83             23.51            21.66/H             10.64      
+                                                                      WEEK 2 DAY 15    764        87.53            31.44             37.68/H               0.67             110.55            -18.90            172.75            35.98            114.23/H            37.92             16.13               5.10      
+                                                                      WEEK 3 DAY 22    814        69.69            13.59             38.39/H               1.38             69.94/L           -59.52            155.35            18.58              88.12             11.80             15.31               4.29      
+                                                                      WEEK 4 DAY 29    844        74.64            18.54              36.62               -0.40              84.59            -44.87            156.15            19.38              71.44             -4.87             12.20               1.18      
+                                                                      WEEK 5 DAY 36    914       39.39/L           -16.71             36.81               -0.21             102.02            -27.44            135.87            -0.90              68.75             -7.56             9.76/L             -1.26      
+    BRA-1/236       32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     WEEK 1 DAY 8     486       37.04/L           -0.79              36.11                0.27            120.31/H            11.74            146.04            -5.09              65.75             -3.33            22.69/H              3.96      
+                                                                      WEEK 2 DAY 15    678        80.66            42.83             35.64/L              -0.21             106.20             -2.37            146.80            -4.32              82.04             12.96             16.89              -1.84      
+                                                                      WEEK 3 DAY 22    762        86.71            48.88              36.16                0.32             104.63             -3.94            76.01/L           -75.12             70.13              1.05             19.70               0.97      
+                                                                      WEEK 4 DAY 29    773        48.43            10.60             35.38/L              -0.47             111.13             2.56             134.79            -16.34             80.78             11.70             17.98              -0.75      
+                                                                      WEEK 5 DAY 36    901       24.05/L           -13.78            35.90/L               0.05             108.01             -0.56            137.95            -13.17             68.35             -0.73             8.48/L             -10.25     
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if
+  outside the Roche standard reference range.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="vsl01_cache/html/sessioninfo_9bb0476c6eb1dc0e4a376f6f88891de6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      
+[5] dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      
+ [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   
+ [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       
+[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    
+[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   
+[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  
+[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         
+[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   
+[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="vsl01_cache/html/snapshot_7c6283b10cc549f90c66bfd99cfd75df">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/listings/vital-signs/vsl01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    } else {
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../listings/pharmacokinetic/pkpl04.html" class="pagination-link">
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+      <a href="../../graphs/efficacy/fstg01.html" class="pagination-link">
+        <span class="nav-page-text">FSTG01</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb7" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb7-1"><a href="#cb7-1"></a><span class="co">---</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="an">title:</span><span class="co"> VSL01</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="an">subtitle:</span><span class="co"> 'Listing of Vital Signs: Safety-Evaluable Patients'</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="co">---</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>------------------------------------------------------------------------</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb7-9"><a href="#cb7-9"></a></span>
+<span id="cb7-10"><a href="#cb7-10"></a>::: panel-tabset</span>
+<span id="cb7-11"><a href="#cb7-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a></span>
+<span id="cb7-13"><a href="#cb7-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb7-14"><a href="#cb7-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a></span>
+<span id="cb7-16"><a href="#cb7-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-17"><a href="#cb7-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-18"><a href="#cb7-18"></a><span class="fu">library</span>(rlistings)</span>
+<span id="cb7-19"><a href="#cb7-19"></a></span>
+<span id="cb7-20"><a href="#cb7-20"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb7-21"><a href="#cb7-21"></a></span>
+<span id="cb7-22"><a href="#cb7-22"></a>get_param_unit_range <span class="ot">&lt;-</span> <span class="cf">function</span>(dataset) {</span>
+<span id="cb7-23"><a href="#cb7-23"></a>  u_rng <span class="ot">&lt;-</span> <span class="fu">lapply</span>(<span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD), <span class="cf">function</span>(p) {</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    dat <span class="ot">&lt;-</span> dataset <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> p)</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="fu">list</span>(</span>
+<span id="cb7-26"><a href="#cb7-26"></a>      <span class="at">unit =</span> <span class="fu">unique</span>(dat<span class="sc">$</span>AVALU),</span>
+<span id="cb7-27"><a href="#cb7-27"></a>      <span class="at">range =</span> <span class="fu">paste0</span>(<span class="fu">unique</span>(dat<span class="sc">$</span>ANRLO), <span class="st">"-"</span>, <span class="fu">unique</span>(dat<span class="sc">$</span>ANRHI))</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    )</span>
+<span id="cb7-29"><a href="#cb7-29"></a>  })</span>
+<span id="cb7-30"><a href="#cb7-30"></a>  <span class="fu">names</span>(u_rng) <span class="ot">&lt;-</span> <span class="fu">unique</span>(dataset<span class="sc">$</span>PARAMCD)</span>
+<span id="cb7-31"><a href="#cb7-31"></a>  u_rng</span>
+<span id="cb7-32"><a href="#cb7-32"></a>}</span>
+<span id="cb7-33"><a href="#cb7-33"></a></span>
+<span id="cb7-34"><a href="#cb7-34"></a>vs_u_rng <span class="ot">&lt;-</span> <span class="fu">get_param_unit_range</span>(advs)</span>
+<span id="cb7-35"><a href="#cb7-35"></a></span>
+<span id="cb7-36"><a href="#cb7-36"></a>advs_sub <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb7-37"><a href="#cb7-37"></a>  <span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(AVAL) <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(VSSEQ)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-38"><a href="#cb7-38"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">CRTNPT =</span> <span class="fu">paste</span>(SITEID, <span class="fu">sub</span>(<span class="st">"^.*-([[:alnum:]]+)$"</span>, <span class="st">"</span><span class="sc">\\</span><span class="st">1"</span>, SUBJID), <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="at">AGSXRC =</span> <span class="fu">paste</span>(AGE, SEX, RACE, <span class="at">sep =</span> <span class="st">"/"</span>),</span>
+<span id="cb7-41"><a href="#cb7-41"></a>    <span class="at">AVAL =</span> <span class="fu">format</span>(<span class="fu">round</span>(AVAL, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>),</span>
+<span id="cb7-42"><a href="#cb7-42"></a>    <span class="at">AVAL_ANRIND =</span> <span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">""</span>), AVAL, <span class="fu">paste</span>(AVAL, <span class="fu">substr</span>(ANRIND, <span class="dv">1</span>, <span class="dv">1</span>), <span class="at">sep =</span> <span class="st">"/"</span>)),</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="at">CHG =</span> <span class="fu">format</span>(<span class="fu">round</span>(CHG, <span class="dv">2</span>), <span class="at">nsmall =</span> <span class="dv">2</span>)</span>
+<span id="cb7-44"><a href="#cb7-44"></a>  )</span>
+<span id="cb7-45"><a href="#cb7-45"></a></span>
+<span id="cb7-46"><a href="#cb7-46"></a>anl_vs <span class="ot">&lt;-</span> advs_sub <span class="sc">%&gt;%</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>  <span class="fu">select</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) <span class="sc">%&gt;%</span></span>
+<span id="cb7-48"><a href="#cb7-48"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb7-49"><a href="#cb7-49"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),</span>
+<span id="cb7-50"><a href="#cb7-50"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb7-51"><a href="#cb7-51"></a>    <span class="at">values_from =</span> <span class="fu">c</span>(AVAL_ANRIND, CHG)</span>
+<span id="cb7-52"><a href="#cb7-52"></a>  )</span>
+<span id="cb7-53"><a href="#cb7-53"></a></span>
+<span id="cb7-54"><a href="#cb7-54"></a>out <span class="ot">&lt;-</span> anl_vs <span class="sc">%&gt;%</span></span>
+<span id="cb7-55"><a href="#cb7-55"></a>  <span class="fu">select</span>(</span>
+<span id="cb7-56"><a href="#cb7-56"></a>    CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_WEIGHT, CHG_WEIGHT, AVAL_ANRIND_TEMP, CHG_TEMP, AVAL_ANRIND_DIABP,</span>
+<span id="cb7-57"><a href="#cb7-57"></a>    CHG_DIABP, AVAL_ANRIND_SYSBP, CHG_SYSBP, AVAL_ANRIND_PULSE, CHG_PULSE, AVAL_ANRIND_RESP, CHG_RESP</span>
+<span id="cb7-58"><a href="#cb7-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-59"><a href="#cb7-59"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb7-60"><a href="#cb7-60"></a>    <span class="at">CRTNPT =</span> <span class="st">"Center/Subject ID"</span>,</span>
+<span id="cb7-61"><a href="#cb7-61"></a>    <span class="at">AGSXRC =</span> <span class="st">"Age/Sex/Race"</span>,</span>
+<span id="cb7-62"><a href="#cb7-62"></a>    <span class="at">TRT01A =</span> <span class="st">"Treatment"</span>,</span>
+<span id="cb7-63"><a href="#cb7-63"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb7-64"><a href="#cb7-64"></a>    <span class="at">ADY =</span> <span class="st">"Study</span><span class="sc">\n</span><span class="st">Day"</span>,</span>
+<span id="cb7-65"><a href="#cb7-65"></a>    <span class="at">AVAL_ANRIND_WEIGHT =</span> <span class="fu">paste0</span>(<span class="st">"Weight</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>WEIGHT<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>WEIGHT<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-66"><a href="#cb7-66"></a>    <span class="at">CHG_WEIGHT =</span> <span class="st">"Weight</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-67"><a href="#cb7-67"></a>    <span class="at">AVAL_ANRIND_TEMP =</span> <span class="fu">paste0</span>(<span class="st">"Temperature Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>TEMP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>TEMP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-68"><a href="#cb7-68"></a>    <span class="at">CHG_TEMP =</span> <span class="st">"Temperature Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-69"><a href="#cb7-69"></a>    <span class="at">AVAL_ANRIND_DIABP =</span> <span class="fu">paste0</span>(<span class="st">"Diastolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>DIABP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>DIABP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-70"><a href="#cb7-70"></a>    <span class="at">CHG_DIABP =</span> <span class="st">"Diastolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-71"><a href="#cb7-71"></a>    <span class="at">AVAL_ANRIND_SYSBP =</span> <span class="fu">paste0</span>(<span class="st">"Systolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>SYSBP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>SYSBP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-72"><a href="#cb7-72"></a>    <span class="at">CHG_SYSBP =</span> <span class="st">"Systolic Blood</span><span class="sc">\n</span><span class="st">Pressure,</span><span class="sc">\n</span><span class="st">Sitting</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-73"><a href="#cb7-73"></a>    <span class="at">AVAL_ANRIND_PULSE =</span> <span class="fu">paste0</span>(<span class="st">"Pulse Rate Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>PULSE<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>PULSE<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-74"><a href="#cb7-74"></a>    <span class="at">CHG_PULSE =</span> <span class="st">"Pulse Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span>,</span>
+<span id="cb7-75"><a href="#cb7-75"></a>    <span class="at">AVAL_ANRIND_RESP =</span> <span class="fu">paste0</span>(<span class="st">"Respiratory Rate</span><span class="sc">\n</span><span class="st">Result</span><span class="sc">\n</span><span class="st">("</span>, vs_u_rng<span class="sc">$</span>RESP<span class="sc">$</span>unit, <span class="st">");</span><span class="sc">\n</span><span class="st">Range:("</span>, vs_u_rng<span class="sc">$</span>RESP<span class="sc">$</span>range, <span class="st">")"</span>),</span>
+<span id="cb7-76"><a href="#cb7-76"></a>    <span class="at">CHG_RESP =</span> <span class="st">"Respiratory Rate</span><span class="sc">\n</span><span class="st">Change from BL"</span></span>
+<span id="cb7-77"><a href="#cb7-77"></a>  )</span>
+<span id="cb7-78"><a href="#cb7-78"></a><span class="in">```</span></span>
+<span id="cb7-79"><a href="#cb7-79"></a></span>
+<span id="cb7-80"><a href="#cb7-80"></a><span class="fu">## Standard Listing</span></span>
+<span id="cb7-81"><a href="#cb7-81"></a></span>
+<span id="cb7-82"><a href="#cb7-82"></a><span class="in">```{r lsting, test = list(lsting = "lsting")}</span></span>
+<span id="cb7-83"><a href="#cb7-83"></a>lsting <span class="ot">&lt;-</span> <span class="fu">as_listing</span>(</span>
+<span id="cb7-84"><a href="#cb7-84"></a>  out,</span>
+<span id="cb7-85"><a href="#cb7-85"></a>  <span class="at">key_cols =</span> <span class="fu">c</span>(<span class="st">"CRTNPT"</span>, <span class="st">"AGSXRC"</span>, <span class="st">"TRT01A"</span>, <span class="st">"AVISIT"</span>),</span>
+<span id="cb7-86"><a href="#cb7-86"></a>  <span class="at">disp_cols =</span> <span class="fu">names</span>(out),</span>
+<span id="cb7-87"><a href="#cb7-87"></a>  <span class="at">main_title =</span> <span class="st">"Listing of Vital Signs: Safety-Evaluable Patients"</span>,</span>
+<span id="cb7-88"><a href="#cb7-88"></a>  <span class="at">main_footer =</span> <span class="st">"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if</span></span>
+<span id="cb7-89"><a href="#cb7-89"></a><span class="st">  outside the Roche standard reference range."</span></span>
+<span id="cb7-90"><a href="#cb7-90"></a>)</span>
+<span id="cb7-91"><a href="#cb7-91"></a></span>
+<span id="cb7-92"><a href="#cb7-92"></a><span class="fu">head</span>(lsting, <span class="dv">20</span>)</span>
+<span id="cb7-93"><a href="#cb7-93"></a><span class="in">```</span></span>
+<span id="cb7-94"><a href="#cb7-94"></a></span>
+<span id="cb7-95"><a href="#cb7-95"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb7-96"><a href="#cb7-96"></a></span>
+<span id="cb7-97"><a href="#cb7-97"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb7-98"><a href="#cb7-98"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/repro.html b/stable/repro.html
new file mode 100644
index 0000000000..375599c578
--- /dev/null
+++ b/stable/repro.html
@@ -0,0 +1,1915 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog – repro</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="site_libs/clipboard/clipboard.min.js"></script>
+<script src="site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="site_libs/quarto-search/fuse.min.js"></script>
+<script src="site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="./">
+<link href="./assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
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+<script src="site_libs/quarto-html/popper.min.js"></script>
+<script src="site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="site_libs/quarto-html/anchor.min.js"></script>
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+<link href="site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
+    "search-label": "Search"
+  }
+}</script><script type="text/plain" cookie-consent="tracking">
+
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+  })(window,document,'script','https://www.google-analytics.com/analytics.js','ga');
+ga('create', 'UA-125641273-1', 'auto');
+
+ga('send', {
+  hitType: 'pageview',
+  'anonymizeIp': true,
+});
+</script><script type="text/javascript" charset="UTF-8">
+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
+  });
+});
+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="assets/css/style.scss">
+</head>
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top"><nav class="navbar navbar-expand navbar-dark "><div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="./index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+<li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
+<li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/development" rel="" target="">
+ <span class="dropdown-text">Development</span></a>
+  </li>  
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
+</li>
+</ul>
+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
+  <a href="" class="quarto-reader-toggle quarto-navigation-tool px-1" onclick="window.quartoToggleReader(); return false;" title="Toggle reader mode">
+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="./index.html" class="sidebar-logo-link">
+      <img src="./assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><div class="quarto-title-block"><div class="quarto-title-tools-only"><h1></h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div><section id="reproducibility" class="level2"><h2 class="anchored" data-anchor-id="reproducibility">Reproducibility</h2>
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="repro_cache/html/sessioninfo_3eceae37f079ec1c8fca4b39376a9b2d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+loaded via a namespace (and not attached):
+ [1] htmlwidgets_1.6.2 compiler_4.3.1    fastmap_1.1.1     cli_3.6.1        
+ [5] tools_4.3.1       htmltools_0.5.6   rstudioapi_0.15.0 yaml_2.3.7       
+ [9] rmarkdown_2.25    knitr_1.44        jsonlite_1.8.7    xfun_0.40        
+[13] digest_0.6.33     rlang_1.1.1       evaluate_0.21    </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="repro_cache/html/snapshot_04ea286955b99e4732d4ff9dd8cc817f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb3-2"><a href="#cb3-2"></a></span>
+<span id="cb3-3"><a href="#cb3-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb3-4"><a href="#cb3-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb3-5"><a href="#cb3-5"></a></span>
+<span id="cb3-6"><a href="#cb3-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb3-7"><a href="#cb3-7"></a></span>
+<span id="cb3-8"><a href="#cb3-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb3-9"><a href="#cb3-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb3-10"><a href="#cb3-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb3-11"><a href="#cb3-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/repro.lock">Download</a></p>
+
+
+<!-- -->
+
+</section></section></main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
+    } else {
+      localAlternateSentinel = value;
+    }
+  }
+  const getColorSchemeSentinel = () => {
+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
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+    toggleColorMode(true);
+  } else {
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+  const icon = "";
+  const anchorJS = new window.AnchorJS();
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+    return false;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+          childEl.remove();
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+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
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+        if (codeDiv.classList.contains(fromCls)) {
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+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb4" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">## Reproducibility</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">### Session Info</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a><span class="in">```{r sessioninfo, message=FALSE}</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a><span class="co">#| renv.ignore: TRUE</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a><span class="fu">sessionInfo</span>()</span>
+<span id="cb4-10"><a href="#cb4-10"></a><span class="in">```</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a><span class="fu">### `.lock` file</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>Download the <span class="in">`.lock`</span> file and use <span class="co">[</span><span class="ot">`renv::restore()`</span><span class="co">](https://rstudio.github.io/renv/reference/restore.html)</span> on it to recreate environment used to generate this website.</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a><span class="in">```{r snapshot, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a><span class="co">#| code-fold: true</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a><span class="co">#| renv.ignore: TRUE</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a></span>
+<span id="cb4-20"><a href="#cb4-20"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-21"><a href="#cb4-21"></a></span>
+<span id="cb4-22"><a href="#cb4-22"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb4-23"><a href="#cb4-23"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb4-24"><a href="#cb4-24"></a></span>
+<span id="cb4-25"><a href="#cb4-25"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb4-26"><a href="#cb4-26"></a></span>
+<span id="cb4-27"><a href="#cb4-27"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-30"><a href="#cb4-30"></a>)</span>
+<span id="cb4-31"><a href="#cb4-31"></a><span class="in">```</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a></span>
+<span id="cb4-33"><a href="#cb4-33"></a><span class="co">[</span><span class="ot">Download</span><span class="co">]</span>(<span class="in">`r if(exists("lock_path")) lock_path else "test"`</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/robots.txt b/stable/robots.txt
new file mode 100644
index 0000000000..1d34213894
--- /dev/null
+++ b/stable/robots.txt
@@ -0,0 +1 @@
+Sitemap: https://insightsengineering.github.io/tlg-catalog/sitemap.xml
diff --git a/stable/search.json b/stable/search.json
new file mode 100644
index 0000000000..f4d5b2296f
--- /dev/null
+++ b/stable/search.json
@@ -0,0 +1,989 @@
+[
+  {
+    "objectID": "tables/exposure/ext01.html",
+    "href": "tables/exposure/ext01.html",
+    "title": "EXT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Optional Analyses\nTable with User-Specified  Categories for Missed Doses\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\nlibrary(tidyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadex &lt;- df_explicit_na(adex)\n\nadex &lt;- adex %&gt;%\n  filter(PARCAT1 == \"OVERALL\") %&gt;%\n  select(STUDYID, USUBJID, ACTARM, PARAMCD, PARAM, AVAL, PARCAT2) %&gt;%\n  mutate(\n    PARAMCD = as.character(PARAMCD),\n    AVALC = \"\"\n  ) %&gt;%\n  droplevels()\n\n# Add new param tdurd for treatment duration.\nset.seed(99)\ntdurd_adsl &lt;- adsl %&gt;%\n  select(STUDYID, USUBJID, ACTARM) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(1:150, size = nrow(adsl), replace = TRUE),\n    AVALC = case_when(\n      0 &lt;= AVAL & AVAL &lt;= 30 ~ \"0 - 30\",\n      31 &lt;= AVAL & AVAL &lt;= 60 ~ \"31 - 60\",\n      61 &lt;= AVAL & AVAL &lt;= 90 ~ \"61 - 90\",\n      TRUE ~ \"&gt;= 91\"\n    )\n  )\ntdurd &lt;- adex %&gt;%\n  filter(PARAMCD == \"TNDOSE\") %&gt;%\n  select(STUDYID, USUBJID, PARCAT2) %&gt;%\n  left_join(tdurd_adsl, by = c(\"STUDYID\", \"USUBJID\"))\n\n# Add new param tndosmis for missed doses.\ntndosmis_adsl &lt;- adsl %&gt;%\n  select(STUDYID, USUBJID, ACTARM) %&gt;%\n  mutate(\n    PARAMCD = \"TNDOSMIS\",\n    PARAM = \"Total number of missed doses during study\",\n    AVAL = sample(0:20, size = nrow(adsl), replace = TRUE),\n    AVALC = \"\"\n  )\ntndosmis &lt;- adex %&gt;%\n  filter(PARAMCD == \"TNDOSE\") %&gt;%\n  select(STUDYID, USUBJID, PARCAT2) %&gt;%\n  left_join(tndosmis_adsl, by = c(\"STUDYID\", \"USUBJID\"))\n\nadex &lt;- dplyr::bind_rows(adex, tdurd, tndosmis) %&gt;%\n  mutate(PARAM = factor(\n    PARAM,\n    levels = c(\n      \"Overall duration (days)\", \"Total dose administered\", \"Total number of doses administered\",\n      \"Total number of missed doses during study\"\n    )\n  ))\n\n\n\n\n\nCode# When summary table contains only categorical or only numeric parameters\n\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARCAT2\", split_label = \"\\nParameter Category (Drug A/Drug B)\", label_pos = \"topleft\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun) %&gt;%\n  analyze_vars(vars = \"AVAL\")\n\nresult &lt;- build_table(lyt = lyt, df = adex, alt_counts_df = adsl)\n\nresult\n\n                                                 A: Drug X        B: Placebo      C: Combination \nParameter Category (Drug A/Drug B)                (N=134)           (N=134)           (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————\nDrug A                                                                                           \n  Overall duration (days)                                                                        \n    n                                               75                67                75       \n    Mean (SD)                                   74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  \n    Median                                         77.0              80.0              78.0      \n    Min - Max                                   5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  \n  Total dose administered                                                                        \n    n                                               75                67                75       \n    Mean (SD)                                 6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)\n    Median                                        6720.0            6480.0            7200.0     \n    Min - Max                                 4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0\n  Total number of doses administered                                                             \n    n                                               75                67                75       \n    Mean (SD)                                    7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                          7.0               7.0               7.0      \n    Min - Max                                    7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \n  Total number of missed doses during study                                                      \n    n                                               75                67                75       \n    Mean (SD)                                   10.5 (5.9)        10.0 (6.1)         9.5 (5.5)   \n    Median                                         10.0              11.0               9.0      \n    Min - Max                                   0.0 - 20.0        0.0 - 19.0        0.0 - 20.0   \nDrug B                                                                                           \n  Overall duration (days)                                                                        \n    n                                               59                67                57       \n    Mean (SD)                                   77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  \n    Median                                         79.0              76.0              65.0      \n    Min - Max                                   2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  \n  Total dose administered                                                                        \n    n                                               59                67                57       \n    Mean (SD)                                 6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)\n    Median                                        6720.0            6240.0            6480.0     \n    Min - Max                                 4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0\n  Total number of doses administered                                                             \n    n                                               59                67                57       \n    Mean (SD)                                    7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                          7.0               7.0               7.0      \n    Min - Max                                    7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \n  Total number of missed doses during study                                                      \n    n                                               59                67                57       \n    Mean (SD)                                    9.1 (6.5)        10.0 (6.3)        10.7 (5.8)   \n    Median                                          9.0              10.0              11.0      \n    Min - Max                                   0.0 - 20.0        0.0 - 20.0        1.0 - 20.0   \n\n\n\n\n\nCode# When summary table contains both categorical and numeric parameters,\n# developer needs to do pre-processing to transform dataset to wide format.\nadex_avalc_wide &lt;- adex %&gt;%\n  filter(PARAMCD == \"TDURD\") %&gt;%\n  select(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(STUDYID, USUBJID, PARCAT2),\n    names_from = PARAMCD,\n    values_from = AVALC\n  ) %&gt;%\n  mutate(\n    TDURDC = factor(TDURD, levels = c(\"0 - 30\", \"31 - 60\", \"61 - 90\", \"&gt;= 91\"))\n  ) %&gt;%\n  select(-TDURD)\n\nanl &lt;- adex %&gt;%\n  select(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(STUDYID, USUBJID, ACTARM, PARCAT2),\n    names_from = PARAMCD,\n    values_from = AVAL\n  ) %&gt;%\n  left_join(adex_avalc_wide, by = c(\"STUDYID\", \"USUBJID\", \"PARCAT2\")) %&gt;%\n  var_relabel(\n    TDOSE = \"Total dose administered\",\n    TNDOSE = \"Total number of doses administered\",\n    TDURD = \"Overall duration (days)\",\n    TNDOSMIS = \"Total number of missed doses during study\",\n    TDURDC = \"Overall duration (days)\"\n  )\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARCAT2\", split_label = \"\\nParameter Category (Drug A/Drug B)\", label_pos = \"topleft\") %&gt;%\n  analyze_vars(\n    vars = c(\"TDURD\", \"TDURDC\", \"TDOSE\", \"TNDOSE\"),\n    var_labels = var_labels(anl)[c(\"TDURD\", \"TDURDC\", \"TDOSE\", \"TNDOSE\")]\n  )\n\nresult &lt;- build_table(lyt = lyt, df = anl, alt_counts_df = adsl)\n\nresult\n\n                                          A: Drug X        B: Placebo      C: Combination \nParameter Category (Drug A/Drug B)         (N=134)           (N=134)           (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————\nDrug A                                                                                    \n  Overall duration (days)                                                                 \n    n                                        75                67                75       \n    Mean (SD)                            74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  \n    Median                                  77.0              80.0              78.0      \n    Min - Max                            5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  \n  Overall duration (days)                                                                 \n    n                                        75                67                75       \n    0 - 30                                12 (16%)         12 (17.9%)         15 (20%)    \n    31 - 60                               18 (24%)         12 (17.9%)        14 (18.7%)   \n    61 - 90                              19 (25.3%)        15 (22.4%)         18 (24%)    \n    &gt;= 91                                26 (34.7%)        28 (41.8%)        28 (37.3%)   \n  Total dose administered                                                                 \n    n                                        75                67                75       \n    Mean (SD)                          6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)\n    Median                                 6720.0            6480.0            7200.0     \n    Min - Max                          4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0\n  Total number of doses administered                                                      \n    n                                        75                67                75       \n    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                   7.0               7.0               7.0      \n    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \nDrug B                                                                                    \n  Overall duration (days)                                                                 \n    n                                        59                67                57       \n    Mean (SD)                            77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  \n    Median                                  79.0              76.0              65.0      \n    Min - Max                            2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  \n  Overall duration (days)                                                                 \n    n                                        59                67                57       \n    0 - 30                                8 (13.6%)        10 (14.9%)        16 (28.1%)   \n    31 - 60                              14 (23.7%)        16 (23.9%)        12 (21.1%)   \n    61 - 90                              15 (25.4%)        17 (25.4%)        11 (19.3%)   \n    &gt;= 91                                22 (37.3%)        24 (35.8%)        18 (31.6%)   \n  Total dose administered                                                                 \n    n                                        59                67                57       \n    Mean (SD)                          6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)\n    Median                                 6720.0            6240.0            6480.0     \n    Min - Max                          4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0\n  Total number of doses administered                                                      \n    n                                        59                67                57       \n    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                   7.0               7.0               7.0      \n    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \n\n\n\n\n\nCode# When summary table contains both categorical and numeric parameters,\n# developer needs to do pre-processing to transform dataset to wide format.\nadex_avalc_wide &lt;- adex %&gt;%\n  filter(PARAMCD == \"TDURD\") %&gt;%\n  select(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(STUDYID, USUBJID, PARCAT2),\n    names_from = PARAMCD,\n    values_from = AVALC\n  ) %&gt;%\n  mutate(\n    TDURDC = factor(TDURD, levels = c(\"0 - 30\", \"31 - 60\", \"61 - 90\", \"&gt;= 91\"))\n  ) %&gt;%\n  select(-TDURD)\n\nanl &lt;- adex %&gt;%\n  select(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(STUDYID, USUBJID, ACTARM, PARCAT2),\n    names_from = PARAMCD,\n    values_from = AVAL\n  ) %&gt;%\n  left_join(adex_avalc_wide, by = c(\"STUDYID\", \"USUBJID\", \"PARCAT2\")) %&gt;%\n  var_relabel(\n    TDOSE = \"Total dose administered\",\n    TNDOSE = \"Total number of doses administered\",\n    TDURD = \"Overall duration (days)\",\n    TNDOSMIS = \"Total number of missed doses during study\",\n    TDURDC = \"Overall duration (days)\"\n  )\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARCAT2\", split_label = \"\\nParameter Category (Drug A/Drug B)\", label_pos = \"topleft\") %&gt;%\n  analyze_vars(\n    vars = c(\"TDURD\", \"TDURDC\", \"TDOSE\", \"TNDOSE\"),\n    var_labels = var_labels(anl)[c(\"TDURD\", \"TDURDC\", \"TDOSE\", \"TNDOSE\")]\n  ) %&gt;%\n  count_missed_doses(\n    \"TNDOSMIS\",\n    thresholds = c(1, 5, 10, 15),\n    var_labels = \"Missed Doses\"\n  )\n\nresult &lt;- build_table(lyt = lyt, df = anl, alt_counts_df = adsl)\n\nresult\n\n                                          A: Drug X        B: Placebo      C: Combination \nParameter Category (Drug A/Drug B)         (N=134)           (N=134)           (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————\nDrug A                                                                                    \n  Overall duration (days)                                                                 \n    n                                        75                67                75       \n    Mean (SD)                            74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  \n    Median                                  77.0              80.0              78.0      \n    Min - Max                            5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  \n  Overall duration (days)                                                                 \n    n                                        75                67                75       \n    0 - 30                                12 (16%)         12 (17.9%)         15 (20%)    \n    31 - 60                               18 (24%)         12 (17.9%)        14 (18.7%)   \n    61 - 90                              19 (25.3%)        15 (22.4%)         18 (24%)    \n    &gt;= 91                                26 (34.7%)        28 (41.8%)        28 (37.3%)   \n  Total dose administered                                                                 \n    n                                        75                67                75       \n    Mean (SD)                          6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)\n    Median                                 6720.0            6480.0            7200.0     \n    Min - Max                          4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0\n  Total number of doses administered                                                      \n    n                                        75                67                75       \n    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                   7.0               7.0               7.0      \n    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \n  Missed Doses                                                                            \n    n                                        75                67                75       \n    At least 1 missed dose               74 (55.2%)         63 (47%)         73 (55.3%)   \n    At least 5 missed doses               59 (44%)         49 (36.6%)        59 (44.7%)   \n    At least 10 missed doses             41 (30.6%)        38 (28.4%)         37 (28%)    \n    At least 15 missed doses             26 (19.4%)        21 (15.7%)        16 (12.1%)   \nDrug B                                                                                    \n  Overall duration (days)                                                                 \n    n                                        59                67                57       \n    Mean (SD)                            77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  \n    Median                                  79.0              76.0              65.0      \n    Min - Max                            2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  \n  Overall duration (days)                                                                 \n    n                                        59                67                57       \n    0 - 30                                8 (13.6%)        10 (14.9%)        16 (28.1%)   \n    31 - 60                              14 (23.7%)        16 (23.9%)        12 (21.1%)   \n    61 - 90                              15 (25.4%)        17 (25.4%)        11 (19.3%)   \n    &gt;= 91                                22 (37.3%)        24 (35.8%)        18 (31.6%)   \n  Total dose administered                                                                 \n    n                                        59                67                57       \n    Mean (SD)                          6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)\n    Median                                 6720.0            6240.0            6480.0     \n    Min - Max                          4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0\n  Total number of doses administered                                                      \n    n                                        59                67                57       \n    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   \n    Median                                   7.0               7.0               7.0      \n    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   \n  Missed Doses                                                                            \n    n                                        59                67                57       \n    At least 1 missed dose               56 (41.8%)         63 (47%)         57 (43.2%)   \n    At least 5 missed doses              41 (30.6%)        50 (37.3%)        47 (35.6%)   \n    At least 10 missed doses             27 (20.1%)        36 (26.9%)        31 (23.5%)   \n    At least 15 missed doses             17 (12.7%)        18 (13.4%)        20 (15.2%)   \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\nadex_labels &lt;- unname(var_labels(adex))\nadex &lt;- adex %&gt;%\n  filter(PARCAT1 == \"OVERALL\") %&gt;%\n  mutate(\n    AVALCAT1 = case_when(\n      PARAMCD == \"TDOSE\" & AVAL &lt; 5000 ~ \"LOW\",\n      PARAMCD == \"TDOSE\" & AVAL &gt;= 5000 ~ \"HIGH\",\n      PARAMCD == \"TNDOSE\" & AVAL &lt; 10 ~ \"&lt; 10\",\n      PARAMCD == \"TNDOSE\" & AVAL &gt;= 10 ~ \"&gt;= 10\"\n    )\n  )\nvar_labels(adex) &lt;- c(adex_labels, \"\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'\n    ),\n    cdisc_dataset(\n      \"ADEX\",\n      adex,\n      code = 'ADEX &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n      ADEX_labels &lt;- unname(var_labels(ADEX))\n      ADEX &lt;- ADEX %&gt;%\n        filter(PARCAT1 == \"OVERALL\") %&gt;%\n        mutate(\n          AVALCAT1 = case_when(\n            PARAMCD == \"TDOSE\" &  AVAL &lt; 5000 ~  \"LOW\",\n            PARAMCD == \"TDOSE\" &  AVAL &gt;= 5000 ~ \"HIGH\",\n            PARAMCD == \"TNDOSE\" &  AVAL &lt; 10 ~  \"&lt; 10\",\n            PARAMCD == \"TNDOSE\" &  AVAL &gt;= 10 ~  \"&gt;= 10\")\n        )\n      var_labels(ADEX) &lt;- c(ADEX_labels, \"\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Exposure Table\",\n      dataname = \"ADEX\",\n      arm_var = choices_selected(\n        choices = variable_choices(adex, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adex, c(\"PARCAT2\", \"PARAM\")),\n        selected = c(\"PARCAT2\", \"PARAM\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adex, c(\"AVAL\", \"AVALCAT1\")),\n        selected = c(\"AVAL\", \"AVALCAT1\")\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adex, \"PARAMCD\", \"PARAM\"),\n        selected = c(\"TDOSE\", \"TNDOSE\")\n      ),\n      denominator = choices_selected(\n        choices = c(\"n\", \"N\", \"omit\"),\n        selected = \"N\"\n      )\n    )\n  ), # Set initial filter state as single study drug to produce smaller table\n  filter = list(ADEX = list(PARCAT2 = \"Drug A\", AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:38:22.4584 pid:14172 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tidyr_1.3.0                  dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/risk-management-plan/rmpt03.html",
+    "href": "tables/risk-management-plan/rmpt03.html",
+    "title": "RMPT03",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Excluding Empty Age Groups\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadex &lt;- df_explicit_na(adex)\n\n# Simulate ADEX records with PARAMCD == \"TDURD\" as they are not in sample scda dataset.\nset.seed(1, kind = \"Mersenne-Twister\")\nadex2 &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE)\n  ) %&gt;%\n  bind_rows(adex)\n\n# Now pre-processing steps are carried out.\nanl &lt;- adex2 %&gt;%\n  filter(\n    PARAMCD == \"TDURD\",\n    PARCAT2 == \"Drug A\",\n    SAFFL == \"Y\"\n  ) %&gt;%\n  mutate(\n    AGEGR1 = factor(ifelse(AGE &lt; 65, \"&lt;65\", \"&gt;=65\")),\n    AGEGR2 = factor(case_when(\n      AGE &lt; 18 ~ \"&lt; 18\",\n      AGE &gt;= 18 & AGE &lt;= 40 ~ \"18 - 40\",\n      AGE &gt; 40 & AGE &lt;= 64 ~ \"41 - 64\",\n      TRUE ~ \"&gt;=65\"\n    ), levels = c(\"&lt; 18\", \"18 - 40\", \"41 - 64\", \"&gt;=65\")),\n    SEX = factor(case_when(\n      SEX == \"F\" ~ \"Female\",\n      SEX == \"M\" ~ \"Male\"\n    ))\n  )\n\nadsl_f &lt;- adsl %&gt;%\n  filter(adsl$SAFFL == \"Y\") %&gt;%\n  mutate(SEX = factor(case_when(\n    SEX == \"F\" ~ \"Female\",\n    SEX == \"M\" ~ \"Male\"\n  )))\n\n\n\n\n\nCodelyt &lt;- basic_table(\n  title = \"Extent of Exposure by Age Group and Gender: Safety-Evaluable Patients\",\n  main_footer = \"* Patient Time is the sum of exposure across all patients in days.\"\n) %&gt;%\n  split_cols_by(\"SEX\", split_fun = add_overall_level(\"Total\", first = FALSE)) %&gt;%\n  summarize_patients_exposure_in_cols(\n    var = \"AVAL\", col_split = TRUE,\n    .labels = c(n_patients = \"Number of Patients\", sum_exposure = \"Patient Time*\"),\n    custom_label = \"Total Number of Patients and Patient Time\"\n  ) %&gt;%\n  analyze_patients_exposure_in_cols(\n    var = \"AGEGR1\",\n    col_split = FALSE\n  ) %&gt;%\n  append_topleft(c(\"\", \"Age group (years)\"))\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_f)\nresult\n\nExtent of Exposure by Age Group and Gender: Safety-Evaluable Patients\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                          Female                                Male                                Total               \nAge group (years)                           Number of Patients   Patient Time*   Number of Patients   Patient Time*   Number of Patients   Patient Time*\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal Number of Patients and Patient Time      134 (58.0%)           12591           83 (49.1%)           8050           217 (54.2%)           20641    \n  &lt;65                                          134 (58.0%)           12591           82 (48.5%)           7970           216 (54.0%)           20561    \n  &gt;=65                                           0 (0.0%)              0              1 (0.6%)             80              1 (0.2%)             80      \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n* Patient Time is the sum of exposure across all patients in days.\n\n\n\n\n\nCodelyt &lt;- basic_table(\n  title = \"Duration of Exposure: Safety-Evaluable Patients\",\n  main_footer = \"* Patient Time is the sum of exposure across all patients in days.\"\n) %&gt;%\n  split_cols_by(\"SEX\", split_fun = add_overall_level(\"Total\", first = FALSE)) %&gt;%\n  summarize_patients_exposure_in_cols(\n    var = \"AVAL\", col_split = TRUE,\n    .labels = c(n_patients = \"Number of Patients\", sum_exposure = \"Patient Time*\"),\n    custom_label = \"Total Number of Patients and Patient Time\"\n  ) %&gt;%\n  analyze_patients_exposure_in_cols(\n    var = \"AGEGR2\",\n    col_split = FALSE\n  ) %&gt;%\n  append_topleft(c(\"\", \"Age group (years)\"))\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\nresult\n\nDuration of Exposure: Safety-Evaluable Patients\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                          Female                                Male                                Total               \nAge group (years)                           Number of Patients   Patient Time*   Number of Patients   Patient Time*   Number of Patients   Patient Time*\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal Number of Patients and Patient Time      134 (58.0%)           12591           83 (49.1%)           8050           217 (54.2%)           20641    \n  18 - 40                                      118 (51.1%)           11203           60 (35.5%)           5787           178 (44.5%)           16990    \n  41 - 64                                       16 (6.9%)            1388            22 (13.0%)           2183            38 (9.5%)            3571     \n  &gt;=65                                           0 (0.0%)              0              1 (0.6%)             80              1 (0.2%)             80      \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n* Patient Time is the sum of exposure across all patients in days.\n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\nset.seed(1, kind = \"Mersenne-Twister\")\n\nlabels &lt;- var_labels(adex)\nadex &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n    AVALU = \"Days\"\n  ) %&gt;%\n  bind_rows(adex)\n\nadex &lt;- adex %&gt;%\n  mutate(\n    AGEGR1 = factor(ifelse(AGE &lt; 65, \"&lt;65\", \"&gt;=65\")),\n    AGEGR2 = factor(case_when(\n      AGE &lt; 18 ~ \"&lt; 18\",\n      AGE &gt;= 18 & AGE &lt;= 40 ~ \"18 - 40\",\n      AGE &gt; 40 & AGE &lt;= 64 ~ \"41 - 64\",\n      TRUE ~ \"&gt;=65\"\n    ), levels = c(\"&lt; 18\", \"18 - 40\", \"41 - 64\", \"&gt;=65\")),\n    SEX = factor(case_when(\n      SEX == \"F\" ~ \"Female\",\n      SEX == \"M\" ~ \"Male\"\n    ))\n  )\n\nvar_labels(adex) &lt;- c(labels, \"Age group (years)\", \"Age group (years)\")\n\nadsl &lt;- adsl %&gt;%\n  mutate(SEX = factor(case_when(\n    SEX == \"F\" ~ \"Female\",\n    SEX == \"M\" ~ \"Male\"\n  )))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n  ADSL &lt;- ADSL %&gt;% filter(ADSL$SAFFL == \"Y\") %&gt;%\n  mutate(SEX = factor(case_when(\n    SEX == \"F\" ~ \"Female\",\n    SEX == \"M\" ~ \"Male\"\n  )))'),\n    cdisc_dataset(\"ADEX\", adex, code = 'ADEX &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n  set.seed(1, kind = \"Mersenne-Twister\")\n  labels &lt;- var_labels(ADEX)\n  ADEX &lt;- ADEX %&gt;%\n    distinct(USUBJID, .keep_all = TRUE) %&gt;%\n    mutate(PARAMCD = \"TDURD\",\n           PARAM = \"Overall duration (days)\",\n           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n           AVALU = \"Days\") %&gt;%\n    bind_rows(ADEX)\n\n  ADEX &lt;- ADEX %&gt;%\n    mutate(\n      AGEGR1 = factor(ifelse(AGE &lt; 65, \"&lt;65\", \"&gt;=65\")),\n      AGEGR2 = factor(case_when(\n        AGE &lt; 18 ~ \"&lt; 18\",\n        AGE &gt;= 18 & AGE &lt;= 40 ~ \"18 - 40\",\n        AGE &gt; 40 & AGE &lt;= 64 ~ \"41 - 64\",\n        TRUE ~ \"&gt;=65\"\n      ), levels = c(\"&lt; 18\", \"18 - 40\", \"41 - 64\", \"&gt;=65\")),\n      SEX = factor(case_when(\n        SEX == \"F\" ~ \"Female\",\n        SEX == \"M\" ~ \"Male\"\n    )))\n  var_labels(ADEX) &lt;- c(labels, \"Age group (years)\", \"Age group (years)\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_exposure(\n      label = \"Duration of Exposure Table\",\n      dataname = \"ADEX\",\n      paramcd = choices_selected(\n        choices = value_choices(adex, \"PARAMCD\", \"PARAM\"),\n        selected = \"TDURD\"\n      ),\n      col_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"SEX\", \"ARM\")),\n        selected = \"SEX\"\n      ),\n      row_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"AGEGR1\", \"AGEGR2\")),\n        selected = \"AGEGR1\"\n      ),\n      parcat = choices_selected(\n        choices = value_choices(adex, \"PARCAT2\"),\n        selected = \"Drug A\"\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:36:59.4025 pid:13976 token:[] teal.modules.clinical Initializing tm_t_exposure\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/risk-management-plan/rmpt04.html",
+    "href": "tables/risk-management-plan/rmpt04.html",
+    "title": "RMPT04",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadex &lt;- df_explicit_na(adex)\n\n# Simulate ADEX records with PARAMCD == \"TDURD\" as they are not in sample scda dataset.\nset.seed(1, kind = \"Mersenne-Twister\")\nadex2 &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE)\n  ) %&gt;%\n  bind_rows(adex)\n\n\n# Now pre-processing steps are carried out.\nanl &lt;- adex2 %&gt;%\n  filter(\n    PARAMCD == \"TDURD\",\n    PARCAT2 == \"Drug A\",\n    SAFFL == \"Y\"\n  )\n\nadsl_f &lt;- adsl %&gt;% filter(adsl$SAFFL == \"Y\")\n\n\n\n\n\nCodelyt &lt;- basic_table(\n  title = \"Extent of Exposure by Ethnic Origin: Safety-Evaluable Patients\",\n  main_footer = \"* Patient Time is the sum of exposure across all patients in days.\",\n  show_colcounts = TRUE\n) %&gt;%\n  analyze_patients_exposure_in_cols(\n    var = \"ETHNIC\",\n    col_split = TRUE,\n    add_total_level = TRUE,\n    custom_label = \"Total\"\n  ) %&gt;%\n  append_topleft(c(\"\", \"Ethnicity\"))\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_f)\nresult\n\nExtent of Exposure by Ethnic Origin: Safety-Evaluable Patients\n\n——————————————————————————————————————————————————\n                          Patients     Person time\nEthnicity                  (N=400)       (N=400)  \n——————————————————————————————————————————————————\nNOT REPORTED              18 (4.5%)       2085    \nHISPANIC OR LATINO        28 (7.0%)       2423    \nNOT HISPANIC OR LATINO   165 (41.2%)      15570   \nUNKNOWN                   6 (1.5%)         563    \nTotal                    217 (54.2%)      20641   \n——————————————————————————————————————————————————\n\n* Patient Time is the sum of exposure across all patients in days.\n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\nset.seed(1, kind = \"Mersenne-Twister\")\nadex &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n    AVALU = \"Days\"\n  ) %&gt;%\n  bind_rows(adex)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADEX\", adex, code = 'ADEX &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n  set.seed(1, kind = \"Mersenne-Twister\")\n  ADEX &lt;- ADEX %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(PARAMCD = \"TDURD\",\n         PARAM = \"Overall duration (days)\",\n         AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n         AVALU = \"Days\") %&gt;%\n  bind_rows(ADEX)'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_exposure(\n      label = \"Duration of Exposure Table\",\n      dataname = \"ADEX\",\n      paramcd = choices_selected(\n        choices = value_choices(adex, \"PARAMCD\", \"PARAM\"),\n        selected = \"TDURD\"\n      ),\n      col_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"ARM\")),\n        selected = NULL\n      ),\n      row_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"ETHNIC\", \"SEX\")),\n        selected = \"ETHNIC\"\n      ),\n      parcat = choices_selected(\n        choices = value_choices(adex, \"PARCAT2\"),\n        selected = \"Drug A\"\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:36:02.8990 pid:13780 token:[] teal.modules.clinical Initializing tm_t_exposure\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/risk-management-plan/rmpt06.html",
+    "href": "tables/risk-management-plan/rmpt06.html",
+    "title": "RMPT06",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting  Sections to Display\nTable with Differences\nTable Modifying Alpha Level and  Type of Confidence Interval\nTable by SMQ\nteal App\nReproducibility\n\n\n\nThe adae and adsl datasets need to undergo data processing before table production. Some new variables are added to these datasets to create the desired tables.\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(\n  adae,\n  omit_columns = c(\"SMQ01NAM\", \"SMQ01SC\", \"SMQ02NAM\", \"SMQ02SC\", \"CQ01NAM\", \"STUDYID\", \"USUBJID\")\n)\n\ndf_max &lt;- aggregate(as.numeric(AETOXGR) ~ USUBJID, data = adae, FUN = max, drop = FALSE)\ncolnames(df_max) &lt;- c(\"USUBJID\", \"WTOXGR\")\n\nadae &lt;- adae %&gt;%\n  left_join(df_max, by = c(\"USUBJID\")) %&gt;%\n  mutate(\n    WTOXGR = factor(WTOXGR, levels = c(\"1\", \"2\", \"3\", \"4\", \"5\")),\n    fl_ser = AESER == \"Y\"\n  ) %&gt;%\n  mutate(\n    WTOXGR = forcats::fct_recode(\n      WTOXGR,\n      \"Grade 1\" = \"1\",\n      \"Grade 2\" = \"2\",\n      \"Grade 3\" = \"3\",\n      \"Grade 4\" = \"4\",\n      \"Grade 5\" = \"5\"\n    ),\n    AEOUT = forcats::fct_recode(\n      AEOUT,\n      \"Fatal outcome\" = \"FATAL\",\n      \"Unresolved\" = \"NOT RECOVERED/NOT RESOLVED\",\n      \"Recovered/Resolved\" = \"RECOVERED/RESOLVED\",\n      \"Resolved with sequelae\" = \"RECOVERED/RESOLVED WITH SEQUELAE\",\n      \"Recovering/Resolving\" = \"RECOVERING/RESOLVING\",\n      \"Unknown outcome\" = \"UNKNOWN\"\n    )\n  ) %&gt;%\n  var_relabel(\n    WTOXGR = \"Worst overall grade\",\n    fl_ser = \"Number of patients with at least one serious AE\"\n  )\n\n# Add AE flag to adsl.\nadsl1 &lt;- adsl %&gt;%\n  mutate(AEFL = ifelse(USUBJID %in% adae$USUBJID, TRUE, FALSE)) %&gt;%\n  var_relabel(AEFL = \"At least one AE\")\n\n\n\n\nPlease note that by default the percentage analysis uses Wald’s confidence interval with continuity correction and the default confidence interval for percentage is 95%. To use a different method for confidence interval calculation, the method name needs to be provided to method argument.\n\nCodelyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  estimate_proportion(\n    vars = \"AEFL\",\n    method = \"clopper-pearson\",\n    .labels = c(\n      n_prop = \"Number of patients with at least one adverse event\",\n      prop_ci = \"95% CI for % of patients with at least one AE (Clopper-Pearson)\"\n    ),\n    table_names = \"est_prop\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl1, alt_counts_df = adsl1)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_values(\n    \"STUDYID\",\n    values = as.character(unique(adae$STUDYID)),\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences(\n    \"WTOXGR\",\n    var_labels = \"Number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"fl_ser\"\n  ) %&gt;%\n  count_occurrences(\n    \"AEOUT\",\n    denom = \"n\",\n    var_labels = \"Number of patients with at least one AE by outcome\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adsl,\n  result_adae[seq_len(nrow(result_adae)), ]\n)\n\nresult\n\n                                                                   A: Drug X      B: Placebo    C: Combination\n                                                                    (N=134)        (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————\nNumber of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  \n95% CI for % of patients with at least one AE (Clopper-Pearson)   (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) \nTotal number of AEs                                                   609            622             703      \nNumber of patients with at least one AE by worst grade                                                        \n  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   \n  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   \n  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  \n  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  \n  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  \nNumber of patients with at least one serious AE                   104 (85.2%)    101 (82.1%)      99 (82.5%)  \nNumber of patients with at least one AE by outcome                                                            \n  Fatal outcome                                                    76 (62.3%)     70 (56.9%)      75 (62.5%)  \n  Unresolved                                                       66 (54.1%)     64 (52.0%)      70 (58.3%)  \n  Recovered/Resolved                                               73 (59.8%)     83 (67.5%)      88 (73.3%)  \n  Resolved with sequelae                                           44 (36.1%)     40 (32.5%)      43 (35.8%)  \n  Recovering/Resolving                                             81 (66.4%)     84 (68.3%)      88 (73.3%)  \n  Unknown outcome                                                  38 (31.1%)     49 (39.8%)      44 (36.7%)  \n\n\n\n\n\nCodelyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  estimate_proportion(\n    vars = \"AEFL\",\n    method = \"clopper-pearson\",\n    .labels = c(\n      n_prop = \"Number of patients with at least one adverse event\",\n      prop_ci = \"95% CI for % of patients with at least one AE (Clopper-Pearson)\"\n    ),\n    table_names = \"est_prop\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl1, alt_counts_df = adsl1)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_values(\n    \"STUDYID\",\n    values = as.character(unique(adae$STUDYID)),\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences(\n    \"WTOXGR\",\n    var_labels = \"Number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"fl_ser\",\n    denom = \"N_col\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adsl,\n  result_adae[seq_len(nrow(result_adae)), ]\n)\n\nresult\n\n                                                                   A: Drug X      B: Placebo    C: Combination\n                                                                    (N=134)        (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————\nNumber of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  \n95% CI for % of patients with at least one AE (Clopper-Pearson)   (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) \nTotal number of AEs                                                   609            622             703      \nNumber of patients with at least one AE by worst grade                                                        \n  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   \n  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   \n  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  \n  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  \n  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  \nNumber of patients with at least one serious AE                   104 (77.6%)    101 (75.4%)      99 (75.0%)  \n\n\n\n\nPlease note that by default the percentage difference analysis also uses Wald’s confidence interval with continuity correction and the default confidence interval is 95%.\n\nCodelyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"AEFL\",\n    method = \"clopper-pearson\",\n    .labels = c(\n      n_prop = \"Number of patients with at least one adverse event\",\n      prop_ci = \"95% CI for % of patients with at least one AE\"\n    ),\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"AEFL\",\n    .labels = c(\n      diff = \"Difference in % of patients with at least one AE\",\n      diff_ci = \"95% CI of difference (Wald, with correction)\"\n    ),\n    table_names = \"est_prop_diff\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl1, alt_counts_df = adsl1)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_values(\n    \"STUDYID\",\n    values = as.character(unique(adae$STUDYID)),\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences(\n    \"WTOXGR\",\n    var_labels = \"Number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"fl_ser\",\n    denom = \"N_col\"\n  ) %&gt;%\n  count_occurrences(\n    \"AEOUT\",\n    denom = \"n\",\n    var_labels = \"Number of patients with at least one AE by outcome\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adsl,\n  result_adae[seq_len(nrow(result_adae)), ]\n)\n\nresult\n\n                                                          A: Drug X      B: Placebo    C: Combination\n                                                           (N=134)        (N=134)         (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————\nNumber of patients with at least one adverse event       122 (91.0%)    123 (91.8%)     120 (90.9%)  \n95% CI for % of patients with at least one AE            (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) \nDifference in % of patients with at least one AE                            0.7             -0.1     \n  95% CI of difference (Wald, with correction)                          (-6.7, 8.2)     (-7.8, 7.5)  \nTotal number of AEs                                          609            622             703      \nNumber of patients with at least one AE by worst grade                                               \n  Grade 1                                                  7 (5.2%)       9 (6.7%)        4 (3.0%)   \n  Grade 2                                                  6 (4.5%)      10 (7.5%)        7 (5.3%)   \n  Grade 3                                                 18 (13.4%)     14 (10.4%)      16 (12.1%)  \n  Grade 4                                                 15 (11.2%)     20 (14.9%)      18 (13.6%)  \n  Grade 5                                                 76 (56.7%)     70 (52.2%)      75 (56.8%)  \nNumber of patients with at least one serious AE          104 (77.6%)    101 (75.4%)      99 (75.0%)  \nNumber of patients with at least one AE by outcome                                                   \n  Fatal outcome                                           76 (62.3%)     70 (56.9%)      75 (62.5%)  \n  Unresolved                                              66 (54.1%)     64 (52.0%)      70 (58.3%)  \n  Recovered/Resolved                                      73 (59.8%)     83 (67.5%)      88 (73.3%)  \n  Resolved with sequelae                                  44 (36.1%)     40 (32.5%)      43 (35.8%)  \n  Recovering/Resolving                                    81 (66.4%)     84 (68.3%)      88 (73.3%)  \n  Unknown outcome                                         38 (31.1%)     49 (39.8%)      44 (36.7%)  \n\n\n\n\nThe confidence level can be changed through the conf_level argument.\n\nCodelyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"AEFL\",\n    conf_level = 0.90,\n    method = \"clopper-pearson\",\n    .labels = c(\n      n_prop = \"Number of patients with at least one adverse event\",\n      prop_ci = \"90% CI for % of patients with at least one AE (Clopper-Pearson)\"\n    ),\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"AEFL\",\n    conf_level = 0.90,\n    method = \"newcombe\",\n    .labels = c(\n      diff = \"Difference in % of patients with at least one AE\",\n      diff_ci = \"90% CI of difference (Newcombe)\"\n    ),\n    table_names = \"est_prop_diff\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl1, alt_counts_df = adsl1)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_values(\n    \"STUDYID\",\n    values = as.character(unique(adae$STUDYID)),\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences(\n    \"WTOXGR\",\n    var_labels = \"Number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"fl_ser\",\n    denom = \"N_col\"\n  ) %&gt;%\n  count_occurrences(\n    \"AEOUT\",\n    denom = \"n\",\n    var_labels = \"Number of patients with at least one AE by outcome\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adsl,\n  result_adae[seq_len(nrow(result_adae)), ]\n)\n\nresult\n\n                                                                   A: Drug X      B: Placebo    C: Combination\n                                                                    (N=134)        (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————\nNumber of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  \n90% CI for % of patients with at least one AE (Clopper-Pearson)   (85.9, 94.8)   (86.8, 95.3)    (85.7, 94.7) \nDifference in % of patients with at least one AE                                     0.7             -0.1     \n  90% CI of difference (Newcombe)                                                (-5.1, 6.6)     (-6.1, 5.8)  \nTotal number of AEs                                                   609            622             703      \nNumber of patients with at least one AE by worst grade                                                        \n  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   \n  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   \n  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  \n  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  \n  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  \nNumber of patients with at least one serious AE                   104 (77.6%)    101 (75.4%)      99 (75.0%)  \nNumber of patients with at least one AE by outcome                                                            \n  Fatal outcome                                                    76 (62.3%)     70 (56.9%)      75 (62.5%)  \n  Unresolved                                                       66 (54.1%)     64 (52.0%)      70 (58.3%)  \n  Recovered/Resolved                                               73 (59.8%)     83 (67.5%)      88 (73.3%)  \n  Resolved with sequelae                                           44 (36.1%)     40 (32.5%)      43 (35.8%)  \n  Recovering/Resolving                                             81 (66.4%)     84 (68.3%)      88 (73.3%)  \n  Unknown outcome                                                  38 (31.1%)     49 (39.8%)      44 (36.7%)  \n\n\n\n\n\nCode# In progress\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       dplyr_1.1.3      tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disposition/pdt01.html",
+    "href": "tables/disposition/pdt01.html",
+    "title": "PDT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\naddv &lt;- synthetic_cdisc_dataset(\"latest\", \"addv\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\naddv &lt;- df_explicit_na(addv)\n\naddv &lt;- addv %&gt;%\n  var_relabel(\n    DVDECOD = \"Category\",\n    DVTERM = \"Description\"\n  )\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one major protocol deviation\",\n      nonunique = \"Total number of major protocol deviations\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"DVDECOD\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(addv$DVDECOD)\n  ) %&gt;%\n  count_occurrences(vars = \"DVTERM\") %&gt;%\n  append_varlabels(addv, \"DVTERM\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = addv, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(path = c(\"DVDECOD\", \"*\", \"DVTERM\"), scorefun = score_occurrences)\n\nresult\n\nCategory                                                              A: Drug X    B: Placebo   C: Combination\n  Description                                                          (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one major protocol deviation   28 (20.9%)   22 (16.4%)     18 (13.6%)  \nTotal number of major protocol deviations                                 49           35             35      \nEXCLUSION CRITERIA                                                                                            \n  Active or untreated or other excluded cns metastases                 2 (1.5%)     4 (3.0%)       1 (0.8%)   \n  Pregnancy criteria                                                   3 (2.2%)     3 (2.2%)       1 (0.8%)   \n  History of other malignancies within the last 5 years                3 (2.2%)     1 (0.7%)       1 (0.8%)   \n  Uncontrolled concurrent condition                                    2 (1.5%)        0           3 (2.3%)   \n  Other exclusion criteria                                             1 (0.7%)        0           2 (1.5%)   \n  Received prior prohibited therapy or medication                      2 (1.5%)     1 (0.7%)          0       \nINCLUSION CRITERIA                                                                                            \n  No signed ICF at study entry                                         5 (3.7%)        0           6 (4.5%)   \n  Ineligible cancer type or current cancer stage                       3 (2.2%)     2 (1.5%)       4 (3.0%)   \n  Inclusion lab values outside allowed limits                          4 (3.0%)     1 (0.7%)          0       \n  Does not meet prior therapy requirements                             2 (1.5%)     1 (0.7%)       1 (0.8%)   \n  Inclusion-related test not done/out of window                        1 (0.7%)     1 (0.7%)          0       \nMEDICATION                                                                                                    \n  Discontinued study drug for unspecified reason                       3 (2.2%)     2 (1.5%)       1 (0.8%)   \n  Significant deviation from planned dose                              3 (2.2%)     1 (0.7%)       2 (1.5%)   \n  Received incorrect study medication                                     0         3 (2.2%)       1 (0.8%)   \n  Received prohibited concomitant medication                           1 (0.7%)     2 (1.5%)       1 (0.8%)   \n  Dose missed or significantly out of window                           2 (1.5%)        0           1 (0.8%)   \nPROCEDURAL                                                                                                    \n  Eligibility-related test not done/out of window                      2 (1.5%)     4 (3.0%)       3 (2.3%)   \n  Omission of screening tumor assessment                               4 (3.0%)     1 (0.7%)       3 (2.3%)   \n  Missed assessment affecting safety/study outcomes                    2 (1.5%)     3 (2.2%)       1 (0.8%)   \n  Failure to sign updated ICF within two visits                        2 (1.5%)     1 (0.7%)       1 (0.8%)   \n  Missed 2 or more efficacy assessments                                1 (0.7%)     2 (1.5%)          0       \n  Omission of complete lab panel required by protocol                     0            0           1 (0.8%)   \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\naddv &lt;- synthetic_cdisc_dataset(\"latest\", \"addv\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\naddv &lt;- df_explicit_na(addv)\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADDV\", addv, code = 'ADDV &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"addv\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Major Protocol Deviations Table\",\n      dataname = \"ADDV\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(addv, c(\"DVTERM\")),\n        selected = c(\"DVTERM\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(addv, c(\"DVDECOD\")),\n        selected = \"DVDECOD\"\n      ),\n      add_total = TRUE,\n      event_type = \"major protocol deviation\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:34:45.1909 pid:13481 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/demography/dmt01.html",
+    "href": "tables/demography/dmt01.html",
+    "title": "DMT01",
+    "section": "",
+    "text": "Data Setup\nTable with an Additional  Study-Specific Continuous Variable\nTable with an Additional  Study-Specific Categorical Variable\nTable with Subgrouping  for Some Analyses\nTable with Additional Vital  Signs Baseline Values\nTable with Additional  Values from ADSUB\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(tidyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\nadsub &lt;- synthetic_cdisc_dataset(\"latest\", \"adsub\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadvs &lt;- df_explicit_na(advs)\nadsub &lt;- df_explicit_na(adsub)\n\n# Change description in variable SEX.\nadsl &lt;- adsl %&gt;%\n  mutate(\n    SEX = factor(case_when(\n      SEX == \"M\" ~ \"Male\",\n      SEX == \"F\" ~ \"Female\",\n      SEX == \"U\" ~ \"Unknown\",\n      SEX == \"UNDIFFERENTIATED\" ~ \"Undifferentiated\"\n    )),\n    AGEGR1 = factor(\n      case_when(\n        between(AGE, 18, 40) ~ \"18-40\",\n        between(AGE, 41, 64) ~ \"41-64\",\n        AGE &gt; 64 ~ \"&gt;=65\"\n      ),\n      levels = c(\"18-40\", \"41-64\", \"&gt;=65\")\n    ),\n    BMRKR1_CAT = factor(\n      case_when(\n        BMRKR1 &lt; 3.5 ~ \"LOW\",\n        BMRKR1 &gt;= 3.5 & BMRKR1 &lt; 10 ~ \"MEDIUM\",\n        BMRKR1 &gt;= 10 ~ \"HIGH\"\n      ),\n      levels = c(\"LOW\", \"MEDIUM\", \"HIGH\")\n    )\n  ) %&gt;%\n  var_relabel(\n    BMRKR1_CAT = \"Biomarker 1 Categories\"\n  )\n# The developer needs to do pre-processing to add necessary variables based on ADVS to analysis dataset.\n# Obtain SBP, DBP and weight.\nget_param_advs &lt;- function(pname, plabel) {\n  ds &lt;- advs %&gt;%\n    filter(PARAM == plabel & AVISIT == \"BASELINE\") %&gt;%\n    select(USUBJID, AVAL)\n\n  colnames(ds) &lt;- c(\"USUBJID\", pname)\n\n  ds\n}\n# The developer needs to do pre-processing to add necessary variables based on ADSUB to analysis dataset.\n# Obtain baseline BMI (BBMISI).\nget_param_adsub &lt;- function(pname, plabel) {\n  ds &lt;- adsub %&gt;%\n    filter(PARAM == plabel) %&gt;%\n    select(USUBJID, AVAL)\n\n  colnames(ds) &lt;- c(\"USUBJID\", pname)\n\n  ds\n}\nadsl &lt;- adsl %&gt;%\n  left_join(get_param_advs(\"SBP\", \"Systolic Blood Pressure\"), by = \"USUBJID\") %&gt;%\n  left_join(get_param_advs(\"DBP\", \"Diastolic Blood Pressure\"), by = \"USUBJID\") %&gt;%\n  left_join(get_param_advs(\"WGT\", \"Weight\"), by = \"USUBJID\") %&gt;%\n  left_join(get_param_adsub(\"BBMISI\", \"Baseline BMI\"), by = \"USUBJID\")\n\n\n\n\n\nCodevars &lt;- c(\"AGE\", \"AGEGR1\", \"SEX\", \"ETHNIC\", \"RACE\", \"BMRKR1\")\nvar_labels &lt;- c(\n  \"Age (yr)\",\n  \"Age Group\",\n  \"Sex\",\n  \"Ethnicity\",\n  \"Race\",\n  \"Continous Level Biomarker 1\"\n)\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  analyze_vars(\n    vars = vars,\n    var_labels = var_labels\n  ) %&gt;%\n  build_table(adsl)\n\nresult\n\n                                               A: Drug X    B: Placebo    C: Combination   All Patients\n                                                (N=134)       (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————————————————————————\nAge (yr)                                                                                               \n  n                                               134           134            132             400     \n  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)      34.9 (7.4) \n  Median                                         33.0          35.0            35.0            34.0    \n  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0     20.0 - 69.0 \nAge Group                                                                                              \n  n                                               134           134            132             400     \n  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)     322 (80.5%) \n  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)      77 (19.2%) \n  &gt;=65                                             0             0           1 (0.8%)        1 (0.2%)  \nSex                                                                                                    \n  n                                               134           134            132             400     \n  Female                                       79 (59%)     82 (61.2%)       70 (53%)      231 (57.8%) \n  Male                                         55 (41%)     52 (38.8%)       62 (47%)      169 (42.2%) \nEthnicity                                                                                              \n  n                                               134           134            132             400     \n  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)       27 (6.8%)  \n  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)       48 (12%)  \n  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)      308 (77%)  \n  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)       17 (4.2%)  \nRace                                                                                                   \n  n                                               134           134            132             400     \n  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)      208 (52%)  \n  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)      91 (22.8%) \n  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)      74 (18.5%) \n  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)       25 (6.2%)  \n  MULTIPLE                                         0         1 (0.7%)           0            1 (0.2%)  \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0            1 (0.2%)  \n  OTHER                                            0             0              0               0      \n  UNKNOWN                                          0             0              0               0      \nContinous Level Biomarker 1                                                                            \n  n                                               134           134            132             400     \n  Mean (SD)                                    6.0 (3.6)     5.7 (3.3)      5.6 (3.5)       5.8 (3.4)  \n  Median                                          5.4           4.8            4.6             4.8     \n  Min - Max                                   0.4 - 17.7    0.6 - 14.2      0.2 - 21.4      0.2 - 21.4 \n\n\n\n\n\nCodevars &lt;- c(\"AGE\", \"AGEGR1\", \"SEX\", \"ETHNIC\", \"RACE\", \"BMRKR1_CAT\")\nvar_labels &lt;- c(\n  \"Age (yr)\",\n  \"Age Group\",\n  \"Sex\",\n  \"Ethnicity\",\n  \"Race\",\n  \"Biomarker 1 Categories\"\n)\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_vars(\n    vars = vars,\n    var_labels = var_labels\n  ) %&gt;%\n  build_table(adsl)\n\nresult\n\n                                               A: Drug X    B: Placebo    C: Combination\n                                                (N=134)       (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————\nAge (yr)                                                                                \n  n                                               134           134            132      \n  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)  \n  Median                                         33.0          35.0            35.0     \n  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0  \nAge Group                                                                               \n  n                                               134           134            132      \n  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)  \n  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)  \n  &gt;=65                                             0             0           1 (0.8%)   \nSex                                                                                     \n  n                                               134           134            132      \n  Female                                       79 (59%)     82 (61.2%)       70 (53%)   \n  Male                                         55 (41%)     52 (38.8%)       62 (47%)   \nEthnicity                                                                               \n  n                                               134           134            132      \n  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)   \n  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)  \n  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)  \n  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)   \nRace                                                                                    \n  n                                               134           134            132      \n  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)  \n  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)  \n  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)  \n  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)   \n  MULTIPLE                                         0         1 (0.7%)           0       \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0       \n  OTHER                                            0             0              0       \n  UNKNOWN                                          0             0              0       \nBiomarker 1 Categories                                                                  \n  n                                               134           134            132      \n  LOW                                         33 (24.6%)    41 (30.6%)      38 (28.8%)  \n  MEDIUM                                      84 (62.7%)    76 (56.7%)      80 (60.6%)  \n  HIGH                                        17 (12.7%)    17 (12.7%)      14 (10.6%)  \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_vars(\n    vars = c(\"AGE\", \"SEX\", \"RACE\"),\n    var_labels = c(\"Age\", \"Sex\", \"Race\")\n  ) %&gt;%\n  split_rows_by(\"STRATA1\",\n    split_fun = split_fun\n  ) %&gt;%\n  analyze_vars(\"BMRKR1\") %&gt;%\n  build_table(adsl)\n\nresult\n\n                                               A: Drug X    B: Placebo    C: Combination\n                                                (N=134)       (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————\nAge                                                                                     \n  n                                               134           134            132      \n  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)  \n  Median                                         33.0          35.0            35.0     \n  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0  \nSex                                                                                     \n  n                                               134           134            132      \n  Female                                       79 (59%)     82 (61.2%)       70 (53%)   \n  Male                                         55 (41%)     52 (38.8%)       62 (47%)   \nRace                                                                                    \n  n                                               134           134            132      \n  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)  \n  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)  \n  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)  \n  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)   \n  MULTIPLE                                         0         1 (0.7%)           0       \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0       \n  OTHER                                            0             0              0       \n  UNKNOWN                                          0             0              0       \nA                                                                                       \n  n                                               38            44              40      \n  Mean (SD)                                    5.8 (3.8)     5.4 (3.2)      5.1 (3.2)   \n  Median                                          5.1           4.5            3.8      \n  Min - Max                                   0.4 - 17.7    1.4 - 14.2      1.5 - 14.0  \nB                                                                                       \n  n                                               47            45              43      \n  Mean (SD)                                    6.1 (3.6)     5.8 (3.6)      5.7 (3.4)   \n  Median                                          5.2           4.8            5.1      \n  Min - Max                                   1.6 - 17.2    0.6 - 13.3      0.2 - 16.5  \nC                                                                                       \n  n                                               49            45              49      \n  Mean (SD)                                    6.0 (3.4)     5.9 (3.2)      6.0 (3.8)   \n  Median                                          5.8           5.6            4.5      \n  Min - Max                                   0.5 - 15.1    1.5 - 13.9      1.2 - 21.4  \n\n\n\n\n\nCoderesult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_vars(\n    vars = c(\"AGE\", \"SEX\", \"RACE\", \"DBP\", \"SBP\"),\n    var_labels = c(\n      \"Age (yr)\",\n      \"Sex\",\n      \"Race\",\n      \"Diastolic Blood Pressure\",\n      \"Systolic Blood Pressure\"\n    )\n  ) %&gt;%\n  build_table(adsl)\n\nresult\n\n                                               A: Drug X      B: Placebo    C: Combination\n                                                (N=134)        (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————\nAge (yr)                                                                                  \n  n                                               134            134             132      \n  Mean (SD)                                    33.8 (6.6)     35.4 (7.9)      35.4 (7.7)  \n  Median                                          33.0           35.0            35.0     \n  Min - Max                                   21.0 - 50.0    21.0 - 62.0     20.0 - 69.0  \nSex                                                                                       \n  n                                               134            134             132      \n  Female                                        79 (59%)      82 (61.2%)       70 (53%)   \n  Male                                          55 (41%)      52 (38.8%)       62 (47%)   \nRace                                                                                      \n  n                                               134            134             132      \n  ASIAN                                        68 (50.7%)      67 (50%)       73 (55.3%)  \n  BLACK OR AFRICAN AMERICAN                    31 (23.1%)     28 (20.9%)      32 (24.2%)  \n  WHITE                                        27 (20.1%)     26 (19.4%)      21 (15.9%)  \n  AMERICAN INDIAN OR ALASKA NATIVE               8 (6%)       11 (8.2%)        6 (4.5%)   \n  MULTIPLE                                         0           1 (0.7%)           0       \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0           1 (0.7%)           0       \n  OTHER                                            0              0               0       \n  UNKNOWN                                          0              0               0       \nDiastolic Blood Pressure                                                                  \n  n                                               134            134             132      \n  Mean (SD)                                   96.5 (19.9)    101.1 (19.9)    102.8 (19.5) \n  Median                                          96.0          100.4           102.0     \n  Min - Max                                   44.3 - 136.6   29.2 - 143.8    49.4 - 153.5 \nSystolic Blood Pressure                                                                   \n  n                                               134            134             132      \n  Mean (SD)                                   151.7 (31.5)   149.5 (26.5)    144.7 (30.1) \n  Median                                         150.1          153.0           146.5     \n  Min - Max                                   69.1 - 231.2   87.2 - 220.9    71.8 - 220.2 \n\n\n\n\n\nCoderesult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_vars(\n    vars = c(\"AGE\", \"SEX\", \"RACE\", \"BBMISI\"),\n    var_labels = c(\n      \"Age (yr)\",\n      \"Sex\",\n      \"Race\",\n      \"Baseline BMI\"\n    )\n  ) %&gt;%\n  build_table(adsl)\n\nresult\n\n                                               A: Drug X     B: Placebo     C: Combination\n                                                (N=134)        (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————\nAge (yr)                                                                                  \n  n                                               134            134             132      \n  Mean (SD)                                   33.8 (6.6)     35.4 (7.9)       35.4 (7.7)  \n  Median                                         33.0           35.0             35.0     \n  Min - Max                                   21.0 - 50.0    21.0 - 62.0     20.0 - 69.0  \nSex                                                                                       \n  n                                               134            134             132      \n  Female                                       79 (59%)      82 (61.2%)        70 (53%)   \n  Male                                         55 (41%)      52 (38.8%)        62 (47%)   \nRace                                                                                      \n  n                                               134            134             132      \n  ASIAN                                       68 (50.7%)      67 (50%)        73 (55.3%)  \n  BLACK OR AFRICAN AMERICAN                   31 (23.1%)     28 (20.9%)       32 (24.2%)  \n  WHITE                                       27 (20.1%)     26 (19.4%)       21 (15.9%)  \n  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)        11 (8.2%)        6 (4.5%)   \n  MULTIPLE                                         0          1 (0.7%)            0       \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0          1 (0.7%)            0       \n  OTHER                                            0              0               0       \n  UNKNOWN                                          0              0               0       \nBaseline BMI                                                                              \n  n                                               134            134             132      \n  Mean (SD)                                   30.0 (18.3)    32.4 (23.2)     30.1 (18.4)  \n  Median                                         27.1           31.1             30.0     \n  Min - Max                                   -6.9 - 75.9   -26.6 - 117.9    -44.2 - 87.5 \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Include `EOSDY` and `DCSREAS` variables below because they contain missing data.\nstopifnot(\n  any(is.na(adsl$EOSDY)),\n  any(is.na(adsl$DCSREAS))\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary(\n      label = \"Demographic Table\",\n      dataname = \"ADSL\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      summarize_vars = choices_selected(\n        c(\"SEX\", \"RACE\", \"BMRKR2\", \"EOSDY\", \"DCSREAS\"),\n        c(\"SEX\", \"RACE\")\n      ),\n      useNA = \"ifany\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:33:28.1316 pid:13285 token:[] teal.modules.clinical Initializing tm_t_summary\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tidyr_1.3.0                  dplyr_1.1.3                 \n [9] scda_0.1.6                   tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt05.html",
+    "href": "tables/lab-results/lbt05.html",
+    "title": "LBT05",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Showing  All Categories\nTable with  Study-Specific  MLAs\nTable of Lab Abnormalities Showing  All Categories But Only for Parameter  Codes with At Least One Abnormality\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\nqntls &lt;- adlb %&gt;%\n  group_by(PARAMCD) %&gt;%\n  summarise(as_tibble(t(quantile(AVAL, probs = c(0.1, 0.9)))), .groups = \"drop_last\") %&gt;%\n  rename(q1 = 2, q2 = 3)\n\nadlb &lt;- adlb %&gt;%\n  left_join(qntls, by = \"PARAMCD\")\n\nset.seed(1)\n\n# Modify ANRIND and create AVALCAT1/PARCAT2\n# PARCAT2 is just used for filtering, but in order to be the\n# filtering as realistic as possible, will create the variable.\nadlb &lt;- adlb %&gt;%\n  mutate(\n    ANRIND = factor(\n      case_when(\n        ANRIND == \"LOW\" & AVAL &lt;= q1 ~ \"LOW LOW\",\n        ANRIND == \"HIGH\" & AVAL &gt;= q2 ~ \"HIGH HIGH\",\n        TRUE ~ as.character(ANRIND)\n      ),\n      levels = c(\"\", \"HIGH\", \"HIGH HIGH\", \"LOW\", \"LOW LOW\", \"NORMAL\")\n    ),\n    AVALCAT1 = factor(\n      case_when(\n        ANRIND %in% c(\"HIGH HIGH\", \"LOW LOW\") ~\n          sample(x = c(\"LAST\", \"REPLICATED\", \"SINGLE\"), size = n(), replace = TRUE, prob = c(0.3, 0.6, 0.1)),\n        TRUE ~ \"\"\n      ),\n      levels = c(\"\", c(\"LAST\", \"REPLICATED\", \"SINGLE\"))\n    ),\n    PARCAT2 = factor(ifelse(ANRIND %in% c(\"HIGH HIGH\", \"LOW LOW\"), \"LS\",\n      sample(c(\"SI\", \"CV\", \"LS\"), size = n(), replace = TRUE)\n    ))\n  ) %&gt;%\n  select(-q1, -q2)\n\n# Pre-processing steps\nadlb_f &lt;- adlb %&gt;%\n  filter(ONTRTFL == \"Y\" & PARCAT2 == \"LS\" & SAFFL == \"Y\" & !is.na(AVAL)) %&gt;%\n  mutate(abn_dir = factor(case_when(\n    ANRIND == \"LOW LOW\" ~ \"Low\",\n    ANRIND == \"HIGH HIGH\" ~ \"High\",\n    TRUE ~ \"\"\n  ), levels = c(\"Low\", \"High\", \"\"))) %&gt;%\n  df_explicit_na()\n\n# Construct analysis map\nmap &lt;- expand.grid(\n  PARAM = levels(adlb$PARAM),\n  abn_dir = c(\"Low\", \"High\"),\n  stringsAsFactors = FALSE\n) %&gt;%\n  arrange(PARAM, desc(abn_dir))\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    label_pos = \"topleft\",\n    split_label = \"Laboratory Test\"\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = \"unique_count\") %&gt;%\n  split_rows_by(\"abn_dir\", split_fun = trim_levels_to_map(map)) %&gt;%\n  count_abnormal_by_marked(\n    var = \"AVALCAT1\",\n    variables = list(id = \"USUBJID\", param = \"PARAM\", direction = \"abn_dir\")\n  ) %&gt;%\n  append_topleft(\"  Direction of Abnormality\")\n\nresult &lt;- build_table(lyt, df = adlb_f, alt_counts_df = adsl)\n\nhas_lbl &lt;- function(lbl) CombinationFunction(function(tr) obj_label(tr) == lbl || sum(unlist(row_values(tr))) != 0)\nresult &lt;- prune_table(result, keep_rows(has_lbl(\"Any Abnormality\")))\n\nresult\n\nLaboratory Test                            A: Drug X    B: Placebo   C: Combination\n  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (n)      125          120            125      \n  Low                                                                              \n    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    \n    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  \n    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  \n  High                                                                             \n    Any Abnormality                            0            0              0       \nC-Reactive Protein Measurement (n)            129          130            121      \n  Low                                                                              \n    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    \n    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  \n    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  \n  High                                                                             \n    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   \n    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  \n    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  \nImmunoglobulin A Measurement (n)              129          122            121      \n  Low                                                                              \n    Any Abnormality                            0            0              0       \n  High                                                                             \n    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   \n    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  \n    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    label_pos = \"topleft\",\n    split_label = \"Laboratory Test\"\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = \"unique_count\") %&gt;%\n  split_rows_by(\"abn_dir\", split_fun = trim_levels_to_map(map)) %&gt;%\n  count_abnormal_by_marked(\n    var = \"AVALCAT1\",\n    variables = list(id = \"USUBJID\", param = \"PARAM\", direction = \"abn_dir\")\n  ) %&gt;%\n  append_topleft(\"  Direction of Abnormality\")\n\nresult &lt;- build_table(lyt, df = adlb_f, alt_counts_df = adsl)\n\nresult\n\nLaboratory Test                            A: Drug X    B: Placebo   C: Combination\n  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (n)      125          120            125      \n  Low                                                                              \n    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    \n    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  \n    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  \n  High                                                                             \n    Single, not last                           0            0              0       \n    Last or replicated                         0            0              0       \n    Any Abnormality                            0            0              0       \nC-Reactive Protein Measurement (n)            129          130            121      \n  Low                                                                              \n    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    \n    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  \n    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  \n  High                                                                             \n    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   \n    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  \n    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  \nImmunoglobulin A Measurement (n)              129          122            121      \n  Low                                                                              \n    Single, not last                           0            0              0       \n    Last or replicated                         0            0              0       \n    Any Abnormality                            0            0              0       \n  High                                                                             \n    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   \n    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  \n    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  \n\n\n\n\n\nCode# This variant reflects user modifications made to the laboratory analysis data set related to Safety Lab Standardization metadata.\n# There is no unique layout level variation.\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    label_pos = \"topleft\",\n    split_label = \"Laboratory Test\",\n    split_fun = trim_levels_in_group(\"abn_dir\", drop_outlevs = TRUE)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = \"unique_count\") %&gt;%\n  split_rows_by(\"abn_dir\") %&gt;%\n  count_abnormal_by_marked(\n    var = \"AVALCAT1\",\n    variables = list(id = \"USUBJID\", param = \"PARAM\", direction = \"abn_dir\")\n  ) %&gt;%\n  append_topleft(\"  Direction of Abnormality\")\n\nresult &lt;- build_table(lyt, df = adlb_f, alt_counts_df = adsl)\n\nresult &lt;- result %&gt;% prune_table()\nresult\n\nLaboratory Test                            A: Drug X    B: Placebo   C: Combination\n  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (n)      125          120            125      \n  Low                                                                              \n    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    \n    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  \n    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  \nC-Reactive Protein Measurement (n)            129          130            121      \n  Low                                                                              \n    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    \n    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  \n    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  \n  High                                                                             \n    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   \n    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  \n    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  \nImmunoglobulin A Measurement (n)              129          122            121      \n  High                                                                             \n    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   \n    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  \n    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  \n\nCode# Another approach would be to create an empirical map by removing the ALT records\n# and use it in `trim_levels_to_map`.\n# this is an a posteriori approach, though.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       \n[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  \n[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt09.html",
+    "href": "tables/lab-results/lbt09.html",
+    "title": "LBT09",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting Sections\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadhy &lt;- synthetic_cdisc_dataset(\"latest\", \"adhy\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadhy_liver &lt;- df_explicit_na(adhy)\n\n# Define values of interest in PARAMCD variable.\nparamcd_tbili_alt &lt;- c(\"BLAL\", \"BGAL\", \"BA2AL\", \"BA5AL\")\nparamcd_tbili_ast &lt;- c(\"BLAS\", \"BGAS\", \"BA2AS\", \"BA5AS\")\n\n# Select LBT09 parameters.\nadhy_liver &lt;- adhy_liver %&gt;%\n  filter(\n    SAFFL == \"Y\",\n    AVISIT %in% c(\"BASELINE\", \"POST-BASELINE\"),\n    PARAMCD %in% c(paramcd_tbili_alt, paramcd_tbili_ast)\n  )\n\n# Let's be explicit about factor levels for AVISIT and PARAMCD.\nadhy_liver &lt;- adhy_liver %&gt;%\n  mutate(\n    AVISIT = factor(AVISIT, levels = c(\"BASELINE\", \"POST-BASELINE\")),\n    PARAMCD = factor(PARAMCD, levels = c(paramcd_tbili_alt, paramcd_tbili_ast))\n  )\n\n# Create indicator and category variables.\nadhy_liver &lt;- adhy_liver %&gt;%\n  mutate(\n    TBILI_CAT = factor( # Create TBILI_CAT categories variable - this is needed so we get the right nesting in the table.\n      case_when(\n        PARAMCD %in% c(paramcd_tbili_alt[1], paramcd_tbili_ast[1]) ~ \"Total Bilirubin &lt;= 2xULN\",\n        PARAMCD %in% c(paramcd_tbili_alt[2], paramcd_tbili_ast[2]) ~ \"Total Bilirubin &gt; 2xULN\",\n        PARAMCD %in% c(paramcd_tbili_alt[3], paramcd_tbili_ast[3]) ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN\",\n        PARAMCD %in% c(paramcd_tbili_alt[4], paramcd_tbili_ast[4]) ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN\"\n      ),\n      levels = c(\n        \"Total Bilirubin &lt;= 2xULN\",\n        \"Total Bilirubin &gt; 2xULN\",\n        \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN\",\n        \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN\"\n      )\n    ),\n    ALTAST_CAT = factor( # Create ALTAST_CAT categories variable - this will be the labels for different ALT/AST categories displayed in the table.\n      case_when(\n        PARAMCD %in% paramcd_tbili_alt & AVALC == \"&gt;3-5ULN\" ~ \"ALT &gt;3 - &lt;= 5xULN\",\n        PARAMCD %in% paramcd_tbili_alt & AVALC == \"&gt;5-10ULN\" ~ \"ALT &gt;5 - &lt;= 10xULN\",\n        PARAMCD %in% paramcd_tbili_alt & AVALC == \"&gt;10-20ULN\" ~ \"ALT &gt;10 - &lt;= 20xULN\",\n        PARAMCD %in% paramcd_tbili_alt & AVALC == \"&gt;20ULN\" ~ \"ALT &gt; 20xULN\",\n        PARAMCD %in% paramcd_tbili_ast & AVALC == \"&gt;3-5ULN\" ~ \"AST &gt;3 - &lt;= 5xULN\",\n        PARAMCD %in% paramcd_tbili_ast & AVALC == \"&gt;5-10ULN\" ~ \"AST &gt;5 - &lt;= 10xULN\",\n        PARAMCD %in% paramcd_tbili_ast & AVALC == \"&gt;10-20ULN\" ~ \"AST &gt;10 - &lt;= 20xULN\",\n        PARAMCD %in% paramcd_tbili_ast & AVALC == \"&gt;20ULN\" ~ \"AST &gt; 20xULN\",\n        TRUE ~ \"Criteria not met\"\n      ),\n      levels = c(\n        \"ALT &gt;3 - &lt;= 5xULN\", \"ALT &gt;5 - &lt;= 10xULN\", \"ALT &gt;10 - &lt;= 20xULN\",\n        \"20\" = \"ALT &gt; 20xULN\",\n        \"AST &gt;3 - &lt;= 5xULN\", \"AST &gt;5 - &lt;= 10xULN\", \"AST &gt;10 - &lt;= 20xULN\", \"AST &gt; 20xULN\",\n        \"Criteria not met\"\n      )\n    ),\n    ALTAST_ind = factor(\n      case_when(\n        PARAMCD %in% paramcd_tbili_alt ~ \"ALT\",\n        PARAMCD %in% paramcd_tbili_ast ~ \"AST\"\n      ),\n      levels = c(\"ALT\", \"AST\")\n    )\n  )\n\nmap &lt;- data.frame(\n  ALTAST_ind = c(rep(\"ALT\", 5), rep(\"AST\", 5)),\n  ALTAST_CAT = c(\n    \"ALT &gt;3 - &lt;= 5xULN\", \"ALT &gt;5 - &lt;= 10xULN\", \"ALT &gt;10 - &lt;= 20xULN\",\n    \"20\" = \"ALT &gt; 20xULN\", \"Criteria not met\",\n    \"AST &gt;3 - &lt;= 5xULN\", \"AST &gt;5 - &lt;= 10xULN\", \"AST &gt;10 - &lt;= 20xULN\", \"AST &gt; 20xULN\", \"Criteria not met\"\n  ),\n  stringsAsFactors = FALSE\n)\n\n\n\n\n\nCoderesult &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"AVISIT\") %&gt;%\n  split_rows_by(\"TBILI_CAT\") %&gt;%\n  # below split helps us get the right denominator between ALT/AST but it can be hidden\n  split_rows_by(\"ALTAST_ind\", split_fun = trim_levels_to_map(map), child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"ALTAST_CAT\",\n    .stats = \"fraction\",\n    denom = \"n\",\n    drop = FALSE\n  ) %&gt;%\n  append_topleft(\"Liver Laboratory Test Criterion\") %&gt;%\n  build_table(df = adhy_liver)\n\n# trim away rows with criteria not met\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- result %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\nLiver Laboratory Test Criterion                                        A: Drug X                        B: Placebo                      C: Combination         \n                                                               BASELINE      POST-BASELINE       BASELINE      POST-BASELINE       BASELINE      POST-BASELINE \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                                                                                                       \n  ALT &gt;3 - &lt;= 5xULN                                         23/134 (17.2%)   15/134 (11.2%)   25/134 (18.7%)   27/134 (20.1%)   27/132 (20.5%)   30/132 (22.7%)\n  ALT &gt;5 - &lt;= 10xULN                                        28/134 (20.9%)   29/134 (21.6%)   29/134 (21.6%)   19/134 (14.2%)   36/132 (27.3%)   29/132 (22.0%)\n  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   30/134 (22.4%)   32/134 (23.9%)   33/134 (24.6%)   28/132 (21.2%)   24/132 (18.2%)\n  ALT &gt; 20xULN                                              32/134 (23.9%)   35/134 (26.1%)   24/134 (17.9%)   23/134 (17.2%)   20/132 (15.2%)   26/132 (19.7%)\n  AST &gt;3 - &lt;= 5xULN                                         31/134 (23.1%)   34/134 (25.4%)   30/134 (22.4%)   26/134 (19.4%)   34/132 (25.8%)   24/132 (18.2%)\n  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   25/134 (18.7%)   26/134 (19.4%)   26/134 (19.4%)   22/132 (16.7%)   27/132 (20.5%)\n  AST &gt;10 - &lt;= 20xULN                                       22/134 (16.4%)   29/134 (21.6%)   16/134 (11.9%)   22/134 (16.4%)   34/132 (25.8%)   19/132 (14.4%)\n  AST &gt; 20xULN                                              20/134 (14.9%)   16/134 (11.9%)   28/134 (20.9%)   31/134 (23.1%)   21/132 (15.9%)   39/132 (29.5%)\nTotal Bilirubin &gt; 2xULN                                                                                                                                        \n  ALT &gt;3 - &lt;= 5xULN                                         40/134 (29.9%)   28/134 (20.9%)   31/134 (23.1%)   28/134 (20.9%)   18/132 (13.6%)   32/132 (24.2%)\n  ALT &gt;5 - &lt;= 10xULN                                        24/134 (17.9%)   29/134 (21.6%)   30/134 (22.4%)   37/134 (27.6%)   33/132 (25.0%)   24/132 (18.2%)\n  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   22/134 (16.4%)   26/134 (19.4%)   18/134 (13.4%)   21/132 (15.9%)   30/132 (22.7%)\n  ALT &gt; 20xULN                                              19/134 (14.2%)   33/134 (24.6%)   23/134 (17.2%)   19/134 (14.2%)   30/132 (22.7%)   22/132 (16.7%)\n  AST &gt;3 - &lt;= 5xULN                                         17/134 (12.7%)   27/134 (20.1%)   36/134 (26.9%)   25/134 (18.7%)   26/132 (19.7%)   34/132 (25.8%)\n  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   28/134 (20.9%)   24/134 (17.9%)   28/134 (20.9%)   20/132 (15.2%)   23/132 (17.4%)\n  AST &gt;10 - &lt;= 20xULN                                       36/134 (26.9%)   28/134 (20.9%)   16/134 (11.9%)   26/134 (19.4%)   33/132 (25.0%)   26/132 (19.7%)\n  AST &gt; 20xULN                                              30/134 (22.4%)   21/134 (15.7%)   30/134 (22.4%)   24/134 (17.9%)   24/132 (18.2%)   25/132 (18.9%)\nTotal Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN                                                                                                      \n  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   22/134 (16.4%)   28/134 (20.9%)   23/134 (17.2%)   38/132 (28.8%)   23/132 (17.4%)\n  ALT &gt;5 - &lt;= 10xULN                                        26/134 (19.4%)   25/134 (18.7%)   19/134 (14.2%)   22/134 (16.4%)   32/132 (24.2%)   32/132 (24.2%)\n  ALT &gt;10 - &lt;= 20xULN                                       26/134 (19.4%)   30/134 (22.4%)   31/134 (23.1%)   30/134 (22.4%)   21/132 (15.9%)   27/132 (20.5%)\n  ALT &gt; 20xULN                                              30/134 (22.4%)   28/134 (20.9%)   24/134 (17.9%)   36/134 (26.9%)   20/132 (15.2%)   23/132 (17.4%)\n  AST &gt;3 - &lt;= 5xULN                                         37/134 (27.6%)   25/134 (18.7%)   31/134 (23.1%)   26/134 (19.4%)   24/132 (18.2%)   36/132 (27.3%)\n  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   32/134 (23.9%)   29/134 (21.6%)   30/134 (22.4%)   26/132 (19.7%)   24/132 (18.2%)\n  AST &gt;10 - &lt;= 20xULN                                       25/134 (18.7%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   29/132 (22.0%)   23/132 (17.4%)\n  AST &gt; 20xULN                                              26/134 (19.4%)   25/134 (18.7%)   23/134 (17.2%)   30/134 (22.4%)   23/132 (17.4%)   24/132 (18.2%)\nTotal Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN                                                                                                      \n  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   21/134 (15.7%)   30/134 (22.4%)   17/134 (12.7%)   28/132 (21.2%)   31/132 (23.5%)\n  ALT &gt;5 - &lt;= 10xULN                                        36/134 (26.9%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   26/132 (19.7%)   29/132 (22.0%)\n  ALT &gt;10 - &lt;= 20xULN                                       30/134 (22.4%)   21/134 (15.7%)   28/134 (20.9%)   36/134 (26.9%)   25/132 (18.9%)   24/132 (18.2%)\n  ALT &gt; 20xULN                                              14/134 (10.4%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   31/132 (23.5%)   23/132 (17.4%)\n  AST &gt;3 - &lt;= 5xULN                                         21/134 (15.7%)   26/134 (19.4%)   29/134 (21.6%)   31/134 (23.1%)   33/132 (25.0%)   19/132 (14.4%)\n  AST &gt;5 - &lt;= 10xULN                                        29/134 (21.6%)   26/134 (19.4%)   24/134 (17.9%)   26/134 (19.4%)   23/132 (17.4%)   32/132 (24.2%)\n  AST &gt;10 - &lt;= 20xULN                                       29/134 (21.6%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   22/132 (16.7%)   21/132 (15.9%)\n  AST &gt; 20xULN                                              34/134 (25.4%)   21/134 (15.7%)   19/134 (14.2%)   28/134 (20.9%)   21/132 (15.9%)   33/132 (25.0%)\n\n\n\n\n\nCoderesult &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"AVISIT\") %&gt;%\n  split_rows_by(\"TBILI_CAT\", split_fun = remove_split_levels(\"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN\")) %&gt;%\n  # below split helps us get the right denominator between ALT/AST but it can be hidden\n  split_rows_by(\"ALTAST_ind\", split_fun = trim_levels_to_map(map), child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"ALTAST_CAT\",\n    .stats = \"fraction\",\n    denom = \"n\",\n    drop = FALSE\n  ) %&gt;%\n  append_topleft(\"Liver Laboratory Test Criterion\") %&gt;%\n  build_table(df = adhy_liver)\n\n# trim away rows with criteria not met\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- result %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\nLiver Laboratory Test Criterion                                        A: Drug X                        B: Placebo                      C: Combination         \n                                                               BASELINE      POST-BASELINE       BASELINE      POST-BASELINE       BASELINE      POST-BASELINE \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                                                                                                       \n  ALT &gt;3 - &lt;= 5xULN                                         23/134 (17.2%)   15/134 (11.2%)   25/134 (18.7%)   27/134 (20.1%)   27/132 (20.5%)   30/132 (22.7%)\n  ALT &gt;5 - &lt;= 10xULN                                        28/134 (20.9%)   29/134 (21.6%)   29/134 (21.6%)   19/134 (14.2%)   36/132 (27.3%)   29/132 (22.0%)\n  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   30/134 (22.4%)   32/134 (23.9%)   33/134 (24.6%)   28/132 (21.2%)   24/132 (18.2%)\n  ALT &gt; 20xULN                                              32/134 (23.9%)   35/134 (26.1%)   24/134 (17.9%)   23/134 (17.2%)   20/132 (15.2%)   26/132 (19.7%)\n  AST &gt;3 - &lt;= 5xULN                                         31/134 (23.1%)   34/134 (25.4%)   30/134 (22.4%)   26/134 (19.4%)   34/132 (25.8%)   24/132 (18.2%)\n  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   25/134 (18.7%)   26/134 (19.4%)   26/134 (19.4%)   22/132 (16.7%)   27/132 (20.5%)\n  AST &gt;10 - &lt;= 20xULN                                       22/134 (16.4%)   29/134 (21.6%)   16/134 (11.9%)   22/134 (16.4%)   34/132 (25.8%)   19/132 (14.4%)\n  AST &gt; 20xULN                                              20/134 (14.9%)   16/134 (11.9%)   28/134 (20.9%)   31/134 (23.1%)   21/132 (15.9%)   39/132 (29.5%)\nTotal Bilirubin &gt; 2xULN                                                                                                                                        \n  ALT &gt;3 - &lt;= 5xULN                                         40/134 (29.9%)   28/134 (20.9%)   31/134 (23.1%)   28/134 (20.9%)   18/132 (13.6%)   32/132 (24.2%)\n  ALT &gt;5 - &lt;= 10xULN                                        24/134 (17.9%)   29/134 (21.6%)   30/134 (22.4%)   37/134 (27.6%)   33/132 (25.0%)   24/132 (18.2%)\n  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   22/134 (16.4%)   26/134 (19.4%)   18/134 (13.4%)   21/132 (15.9%)   30/132 (22.7%)\n  ALT &gt; 20xULN                                              19/134 (14.2%)   33/134 (24.6%)   23/134 (17.2%)   19/134 (14.2%)   30/132 (22.7%)   22/132 (16.7%)\n  AST &gt;3 - &lt;= 5xULN                                         17/134 (12.7%)   27/134 (20.1%)   36/134 (26.9%)   25/134 (18.7%)   26/132 (19.7%)   34/132 (25.8%)\n  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   28/134 (20.9%)   24/134 (17.9%)   28/134 (20.9%)   20/132 (15.2%)   23/132 (17.4%)\n  AST &gt;10 - &lt;= 20xULN                                       36/134 (26.9%)   28/134 (20.9%)   16/134 (11.9%)   26/134 (19.4%)   33/132 (25.0%)   26/132 (19.7%)\n  AST &gt; 20xULN                                              30/134 (22.4%)   21/134 (15.7%)   30/134 (22.4%)   24/134 (17.9%)   24/132 (18.2%)   25/132 (18.9%)\nTotal Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN                                                                                                      \n  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   21/134 (15.7%)   30/134 (22.4%)   17/134 (12.7%)   28/132 (21.2%)   31/132 (23.5%)\n  ALT &gt;5 - &lt;= 10xULN                                        36/134 (26.9%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   26/132 (19.7%)   29/132 (22.0%)\n  ALT &gt;10 - &lt;= 20xULN                                       30/134 (22.4%)   21/134 (15.7%)   28/134 (20.9%)   36/134 (26.9%)   25/132 (18.9%)   24/132 (18.2%)\n  ALT &gt; 20xULN                                              14/134 (10.4%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   31/132 (23.5%)   23/132 (17.4%)\n  AST &gt;3 - &lt;= 5xULN                                         21/134 (15.7%)   26/134 (19.4%)   29/134 (21.6%)   31/134 (23.1%)   33/132 (25.0%)   19/132 (14.4%)\n  AST &gt;5 - &lt;= 10xULN                                        29/134 (21.6%)   26/134 (19.4%)   24/134 (17.9%)   26/134 (19.4%)   23/132 (17.4%)   32/132 (24.2%)\n  AST &gt;10 - &lt;= 20xULN                                       29/134 (21.6%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   22/132 (16.7%)   21/132 (15.9%)\n  AST &gt; 20xULN                                              34/134 (25.4%)   21/134 (15.7%)   19/134 (14.2%)   28/134 (20.9%)   21/132 (15.9%)   33/132 (25.0%)\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt06.html",
+    "href": "tables/lab-results/lbt06.html",
+    "title": "LBT06",
+    "section": "",
+    "text": "Data Setup\nStandard Table for  Single Lab Test\nStandard Table for  Multiple Lab Tests\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n# Please note that df_explict_na has a na_level argument defaulting to \"&lt;Missing&gt;\",\n# Please don't change the na_level to anything other than NA, empty string or the default \"&lt;Missing&gt;\".\n\nadlb_f &lt;- adlb %&gt;%\n  dplyr::filter(ABLFL != \"Y\") %&gt;%\n  dplyr::filter(!(AVISIT %in% c(\"SCREENING\", \"BASELINE\"))) %&gt;%\n  dplyr::mutate(AVISIT = droplevels(AVISIT)) %&gt;%\n  var_relabel(AVISIT = \"Visit\")\n\nadlb_f_crp &lt;- adlb_f %&gt;% dplyr::filter(PARAMCD == \"CRP\")\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f_crp$AVISIT)) %&gt;%\n  count_abnormal_by_baseline(\n    \"ANRIND\",\n    abnormal = c(Low = \"LOW\", High = \"HIGH\"),\n    .indent_mods = 4L\n  ) %&gt;%\n  append_varlabels(adlb_f_crp, \"ANRIND\", indent = 1L) %&gt;%\n  append_topleft(\"    Baseline Status\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adlb_f_crp,\n  alt_counts_df = adsl\n) %&gt;%\n  trim_rows()\n\nresult\n\nVisit                                                                                  \n  Analysis Reference Range Indicator     A: Drug X        B: Placebo     C: Combination\n    Baseline Status                       (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————\nWEEK 1 DAY 8                                                                           \n  Low                                                                                  \n            Not low                    16/119 (13.4%)   22/113 (19.5%)   24/112 (21.4%)\n            Low                         2/15 (13.3%)     2/21 (9.5%)       7/20 (35%)  \n            Total                      18/134 (13.4%)   24/134 (17.9%)   31/132 (23.5%)\n  High                                                                                 \n            Not high                   21/114 (18.4%)   20/112 (17.9%)   17/115 (14.8%)\n            High                         2/20 (10%)      4/22 (18.2%)     3/17 (17.6%) \n            Total                      23/134 (17.2%)   24/134 (17.9%)   20/132 (15.2%)\nWEEK 2 DAY 15                                                                          \n  Low                                                                                  \n            Not low                    26/119 (21.8%)   20/113 (17.7%)   12/112 (10.7%)\n            Low                         2/15 (13.3%)     3/21 (14.3%)      4/20 (20%)  \n            Total                      28/134 (20.9%)   23/134 (17.2%)   16/132 (12.1%)\n  High                                                                                 \n            Not high                   15/114 (13.2%)   17/112 (15.2%)    15/115 (13%) \n            High                         2/20 (10%)      4/22 (18.2%)     4/17 (23.5%) \n            Total                      17/134 (12.7%)   21/134 (15.7%)   19/132 (14.4%)\nWEEK 3 DAY 22                                                                          \n  Low                                                                                  \n            Not low                    15/119 (12.6%)   21/113 (18.6%)   18/112 (16.1%)\n            Low                             0/15         3/21 (14.3%)         0/20     \n            Total                      15/134 (11.2%)   24/134 (17.9%)   18/132 (13.6%)\n  High                                                                                 \n            Not high                   22/114 (19.3%)   18/112 (16.1%)   17/115 (14.8%)\n            High                         2/20 (10%)      5/22 (22.7%)     1/17 (5.9%)  \n            Total                      24/134 (17.9%)   23/134 (17.2%)   18/132 (13.6%)\nWEEK 4 DAY 29                                                                          \n  Low                                                                                  \n            Not low                    30/119 (25.2%)   13/113 (11.5%)   16/112 (14.3%)\n            Low                          3/15 (20%)      2/21 (9.5%)       5/20 (25%)  \n            Total                      33/134 (24.6%)   15/134 (11.2%)   21/132 (15.9%)\n  High                                                                                 \n            Not high                   17/114 (14.9%)   11/112 (9.8%)    16/115 (13.9%)\n            High                         2/20 (10%)      6/22 (27.3%)     3/17 (17.6%) \n            Total                      19/134 (14.2%)   17/134 (12.7%)   19/132 (14.4%)\nWEEK 5 DAY 36                                                                          \n  Low                                                                                  \n            Not low                    17/119 (14.3%)   19/113 (16.8%)   16/112 (14.3%)\n            Low                         2/15 (13.3%)     3/21 (14.3%)      5/20 (25%)  \n            Total                      19/134 (14.2%)   22/134 (16.4%)   21/132 (15.9%)\n  High                                                                                 \n            Not high                   19/114 (16.7%)   17/112 (15.2%)   11/115 (9.6%) \n            High                         4/20 (20%)      6/22 (27.3%)     2/17 (11.8%) \n            Total                      23/134 (17.2%)   23/134 (17.2%)   13/132 (9.8%) \n\n\n\n\n\nCode# The following code generates one large table for multiple lab tests.\n# If separate tables are needed for each lab test per GDSR standard, use the code for \"single lab test\".\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f$PARAM)) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f$AVISIT)) %&gt;%\n  count_abnormal_by_baseline(\n    \"ANRIND\",\n    abnormal = c(Low = \"LOW\", High = \"HIGH\"),\n    .indent_mods = 4L\n  ) %&gt;%\n  append_varlabels(adlb_f, \"ANRIND\", indent = 2L) %&gt;%\n  append_topleft(\"      Baseline Status\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adlb_f,\n  alt_counts_df = adsl\n) %&gt;%\n  trim_rows()\n\nresult\n\nParameter                                                                                \n  Visit                                                                                  \n    Analysis Reference Range Indicator     A: Drug X        B: Placebo     C: Combination\n      Baseline Status                       (N=134)          (N=134)          (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                     \n  WEEK 1 DAY 8                                                                           \n    Low                                                                                  \n              Not low                    19/113 (16.8%)   13/117 (11.1%)   14/123 (11.4%)\n              Low                         2/21 (9.5%)      1/17 (5.9%)      1/9 (11.1%)  \n              Total                      21/134 (15.7%)   14/134 (10.4%)   15/132 (11.4%)\n    High                                                                                 \n              Not high                       0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n  WEEK 2 DAY 15                                                                          \n    Low                                                                                  \n              Not low                     17/113 (15%)    13/117 (11.1%)   13/123 (10.6%)\n              Low                         2/21 (9.5%)      2/17 (11.8%)     4/9 (44.4%)  \n              Total                      19/134 (14.2%)   15/134 (11.2%)   17/132 (12.9%)\n    High                                                                                 \n              Not high                       0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n  WEEK 3 DAY 22                                                                          \n    Low                                                                                  \n              Not low                    10/113 (8.8%)    20/117 (17.1%)   21/123 (17.1%)\n              Low                          4/21 (19%)      4/17 (23.5%)     2/9 (22.2%)  \n              Total                      14/134 (10.4%)   24/134 (17.9%)   23/132 (17.4%)\n    High                                                                                 \n              Not high                       0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n  WEEK 4 DAY 29                                                                          \n    Low                                                                                  \n              Not low                    15/113 (13.3%)   19/117 (16.2%)   18/123 (14.6%)\n              Low                         2/21 (9.5%)      3/17 (17.6%)     1/9 (11.1%)  \n              Total                      17/134 (12.7%)   22/134 (16.4%)   19/132 (14.4%)\n    High                                                                                 \n              Not high                       0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n  WEEK 5 DAY 36                                                                          \n    Low                                                                                  \n              Not low                     17/113 (15%)    23/117 (19.7%)   18/123 (14.6%)\n              Low                             0/21         1/17 (5.9%)      1/9 (11.1%)  \n              Total                      17/134 (12.7%)   24/134 (17.9%)   19/132 (14.4%)\n    High                                                                                 \n              Not high                       0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \nC-Reactive Protein Measurement                                                           \n  WEEK 1 DAY 8                                                                           \n    Low                                                                                  \n              Not low                    16/119 (13.4%)   22/113 (19.5%)   24/112 (21.4%)\n              Low                         2/15 (13.3%)     2/21 (9.5%)       7/20 (35%)  \n              Total                      18/134 (13.4%)   24/134 (17.9%)   31/132 (23.5%)\n    High                                                                                 \n              Not high                   21/114 (18.4%)   20/112 (17.9%)   17/115 (14.8%)\n              High                         2/20 (10%)      4/22 (18.2%)     3/17 (17.6%) \n              Total                      23/134 (17.2%)   24/134 (17.9%)   20/132 (15.2%)\n  WEEK 2 DAY 15                                                                          \n    Low                                                                                  \n              Not low                    26/119 (21.8%)   20/113 (17.7%)   12/112 (10.7%)\n              Low                         2/15 (13.3%)     3/21 (14.3%)      4/20 (20%)  \n              Total                      28/134 (20.9%)   23/134 (17.2%)   16/132 (12.1%)\n    High                                                                                 \n              Not high                   15/114 (13.2%)   17/112 (15.2%)    15/115 (13%) \n              High                         2/20 (10%)      4/22 (18.2%)     4/17 (23.5%) \n              Total                      17/134 (12.7%)   21/134 (15.7%)   19/132 (14.4%)\n  WEEK 3 DAY 22                                                                          \n    Low                                                                                  \n              Not low                    15/119 (12.6%)   21/113 (18.6%)   18/112 (16.1%)\n              Low                             0/15         3/21 (14.3%)         0/20     \n              Total                      15/134 (11.2%)   24/134 (17.9%)   18/132 (13.6%)\n    High                                                                                 \n              Not high                   22/114 (19.3%)   18/112 (16.1%)   17/115 (14.8%)\n              High                         2/20 (10%)      5/22 (22.7%)     1/17 (5.9%)  \n              Total                      24/134 (17.9%)   23/134 (17.2%)   18/132 (13.6%)\n  WEEK 4 DAY 29                                                                          \n    Low                                                                                  \n              Not low                    30/119 (25.2%)   13/113 (11.5%)   16/112 (14.3%)\n              Low                          3/15 (20%)      2/21 (9.5%)       5/20 (25%)  \n              Total                      33/134 (24.6%)   15/134 (11.2%)   21/132 (15.9%)\n    High                                                                                 \n              Not high                   17/114 (14.9%)   11/112 (9.8%)    16/115 (13.9%)\n              High                         2/20 (10%)      6/22 (27.3%)     3/17 (17.6%) \n              Total                      19/134 (14.2%)   17/134 (12.7%)   19/132 (14.4%)\n  WEEK 5 DAY 36                                                                          \n    Low                                                                                  \n              Not low                    17/119 (14.3%)   19/113 (16.8%)   16/112 (14.3%)\n              Low                         2/15 (13.3%)     3/21 (14.3%)      5/20 (25%)  \n              Total                      19/134 (14.2%)   22/134 (16.4%)   21/132 (15.9%)\n    High                                                                                 \n              Not high                   19/114 (16.7%)   17/112 (15.2%)   11/115 (9.6%) \n              High                         4/20 (20%)      6/22 (27.3%)     2/17 (11.8%) \n              Total                      23/134 (17.2%)   23/134 (17.2%)   13/132 (9.8%) \nImmunoglobulin A Measurement                                                             \n  WEEK 1 DAY 8                                                                           \n    Low                                                                                  \n              Not low                        0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n    High                                                                                 \n              Not high                   18/119 (15.1%)   20/116 (17.2%)   14/113 (12.4%)\n              High                        1/15 (6.7%)      5/18 (27.8%)     4/19 (21.1%) \n              Total                      19/134 (14.2%)   25/134 (18.7%)   18/132 (13.6%)\n  WEEK 2 DAY 15                                                                          \n    Low                                                                                  \n              Not low                        0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n    High                                                                                 \n              Not high                   16/119 (13.4%)   13/116 (11.2%)   12/113 (10.6%)\n              High                        1/15 (6.7%)      1/18 (5.6%)      2/19 (10.5%) \n              Total                      17/134 (12.7%)   14/134 (10.4%)   14/132 (10.6%)\n  WEEK 3 DAY 22                                                                          \n    Low                                                                                  \n              Not low                        0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n    High                                                                                 \n              Not high                   17/119 (14.3%)   15/116 (12.9%)   21/113 (18.6%)\n              High                            0/15         1/18 (5.6%)      1/19 (5.3%)  \n              Total                      17/134 (12.7%)   16/134 (11.9%)   22/132 (16.7%)\n  WEEK 4 DAY 29                                                                          \n    Low                                                                                  \n              Not low                        0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n    High                                                                                 \n              Not high                    19/119 (16%)    16/116 (13.8%)   19/113 (16.8%)\n              High                        4/15 (26.7%)     5/18 (27.8%)     3/19 (15.8%) \n              Total                      23/134 (17.2%)   21/134 (15.7%)   22/132 (16.7%)\n  WEEK 5 DAY 36                                                                          \n    Low                                                                                  \n              Not low                        0/134            0/134            0/132     \n              Total                          0/134            0/134            0/132     \n    High                                                                                 \n              Not high                   16/119 (13.4%)   21/116 (18.1%)   20/113 (17.7%)\n              High                        1/15 (6.7%)      3/18 (16.7%)         0/19     \n              Total                      17/134 (12.7%)   24/134 (17.9%)   20/132 (15.2%)\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt10.html",
+    "href": "tables/lab-results/lbt10.html",
+    "title": "LBT10",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting Sections\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadhy &lt;- synthetic_cdisc_dataset(\"latest\", \"adhy\")\n\nadhy_liver &lt;- adhy %&gt;%\n  filter(PARAMCD %in% c(\n    \"BL2AL2CU\", \"BL2AS2CU\", \"BG2AL2CU\", \"BG2AS2CU\", \"B2A2L2CU\", \"B2A2S2CU\", \"B2A5L2CU\", \"B2A5S2CU\"\n  )) %&gt;%\n  mutate(PARAMCAT = case_when(\n    PARAMCD %in% c(\"BL2AL2CU\", \"BL2AS2CU\") ~ \"Total Bilirubin &lt;= 2xULN\",\n    PARAMCD %in% c(\"BG2AL2CU\", \"BG2AS2CU\") ~ \"Total Bilirubin &gt; 2xULN\",\n    PARAMCD %in% c(\"B2A2L2CU\", \"B2A2S2CU\") ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN\",\n    PARAMCD %in% c(\"B2A5L2CU\", \"B2A5S2CU\") ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN\"\n  )) %&gt;%\n  mutate(AVALC_FORMAT = case_when(\n    PARAMCD %in% c(\"BL2AL2CU\", \"BG2AL2CU\", \"B2A2L2CU\", \"B2A5L2CU\") & AVALC == \"Y\" ~ \"ALT &gt;3xULN at 2 Visits\",\n    PARAMCD %in% c(\"BL2AS2CU\", \"BG2AS2CU\", \"B2A2S2CU\", \"B2A5S2CU\") & AVALC == \"Y\" ~ \"AST &gt;3xULN at 2 Visits\",\n    TRUE ~ \"Criteria not met\"\n  ))\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nanl &lt;- df_explicit_na(adhy_liver)\n\n\n\n\n\nCodetbl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_rows_by(\"PARAMCAT\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"AVALC_FORMAT\",\n    .stats = c(\"fraction\"),\n    denom = \"n\",\n    drop = TRUE\n  ) %&gt;%\n  build_table(anl, alt_counts_df = adsl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- tbl %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                               ARM A            ARM B            ARM C     \n                              (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                   \n  ALT &gt;3xULN at 2 Visits   20/134 (14.9%)   21/134 (15.7%)   20/132 (15.2%)\n  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   25/134 (18.7%)   27/132 (20.5%)\nTotal Bilirubin &gt; 2xULN                                                    \n  ALT &gt;3xULN at 2 Visits   24/134 (17.9%)   32/134 (23.9%)   24/132 (18.2%)\n  AST &gt;3xULN at 2 Visits   33/134 (24.6%)   29/134 (21.6%)   25/132 (18.9%)\n\n\n\n\n\nCodetbl2 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_rows_by(\"PARAMCAT\", split_fun = remove_split_levels(\"Total Bilirubin &gt; 2xULN\")) %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"AVALC_FORMAT\",\n    .stats = c(\"fraction\"),\n    denom = \"n\",\n    drop = TRUE\n  ) %&gt;%\n  build_table(anl, alt_counts_df = adsl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- tbl2 %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                               ARM A            ARM B            ARM C     \n                              (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                   \n  ALT &gt;3xULN at 2 Visits   20/134 (14.9%)   21/134 (15.7%)   20/132 (15.2%)\n  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   25/134 (18.7%)   27/132 (20.5%)\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt03.html",
+    "href": "tables/lab-results/lbt03.html",
+    "title": "LBT03",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\nFor illustration purposes, this example focuses on “C-Reactive Protein Measurement” starting from baseline, while excluding visit at week 1 for subjects who were randomized to the placebo group.\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\nsaved_labels &lt;- var_labels(adlb)\n\nadlb_f &lt;- adlb %&gt;%\n  filter(\n    PARAM == \"C-Reactive Protein Measurement\",\n    !(ARM == \"B: Placebo\" &\n      AVISIT == \"WEEK 1 DAY 8\"),\n    AVISIT != \"SCREENING\"\n  ) %&gt;%\n  dplyr::mutate(\n    AVISIT = droplevels(AVISIT),\n    ABLFLL = ABLFL == \"Y\"\n  )\n\nvar_labels(adlb_f) &lt;- c(saved_labels, \"\")\n\n\n\n\nThe LBT03 template is the result of a junction between the analysis of AVAL at baseline and CHG at visit time. AVAL is summarized for baseline visits and and CHG is summarized for post-baseline visits.\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f$AVISIT)) %&gt;%\n  summarize_change(\n    \"CHG\",\n    variables = list(value = \"AVAL\", baseline_flag = \"ABLFLL\"),\n    na.rm = TRUE\n  )\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adlb_f,\n  alt_counts_df = adsl\n)\n\nresult\n\nAnalysis Visit    A: Drug X      B: Placebo    C: Combination\n                   (N=134)        (N=134)         (N=132)    \n—————————————————————————————————————————————————————————————\nBASELINE                                                     \n  n                  134            134             132      \n  Mean (SD)      9.06 (0.93)    8.99 (0.98)     8.98 (0.89)  \n  Median             9.07           8.92            8.96     \n  Min - Max      6.21 - 11.87   6.23 - 11.63    6.24 - 11.18 \nWEEK 1 DAY 8                                                 \n  n                  134             0              132      \n  Mean (SD)      -0.05 (1.38)        NA         -0.02 (1.30) \n  Median            -0.17            NA             0.02     \n  Min - Max      -3.56 - 3.48        NA         -3.28 - 3.33 \nWEEK 2 DAY 15                                                \n  n                  134            134             132      \n  Mean (SD)      -0.19 (1.47)   0.01 (1.45)     0.15 (1.25)  \n  Median            -0.27          -0.00            0.15     \n  Min - Max      -4.53 - 4.45   -3.79 - 3.43    -2.92 - 3.28 \nWEEK 3 DAY 22                                                \n  n                  134            134             132      \n  Mean (SD)      0.03 (1.38)    -0.02 (1.49)    0.02 (1.34)  \n  Median             0.15          -0.04            0.20     \n  Min - Max      -3.95 - 2.99   -4.28 - 4.24    -2.76 - 3.26 \nWEEK 4 DAY 29                                                \n  n                  134            134             132      \n  Mean (SD)      -0.26 (1.45)   0.05 (1.24)     -0.01 (1.17) \n  Median            -0.37           0.10           -0.06     \n  Min - Max      -3.74 - 4.15   -3.34 - 3.71    -3.06 - 3.22 \nWEEK 5 DAY 36                                                \n  n                  134            134             132      \n  Mean (SD)      -0.02 (1.50)   0.07 (1.34)     0.03 (1.27)  \n  Median             0.01           0.15            0.05     \n  Min - Max      -4.15 - 3.96   -3.50 - 3.53    -3.63 - 4.78 \n\n\nIn the final step, a new variable is derived from AVISIT that can specify the method of estimation of the evaluated change.\n\nCodeadlb_f &lt;- adlb_f %&gt;% mutate(AVISIT_header = recode(AVISIT,\n  \"BASELINE\" = \"BASELINE\",\n  \"WEEK 1 DAY 8\" = \"WEEK 1 DAY 8 value minus baseline\",\n  \"WEEK 2 DAY 15\" = \"WEEK 2 DAY 15 value minus baseline\",\n  \"WEEK 3 DAY 22\" = \"WEEK 3 DAY 22 value minus baseline\",\n  \"WEEK 4 DAY 29\" = \"WEEK 4 DAY 29 value minus baseline\",\n  \"WEEK 5 DAY 36\" = \"WEEK 5 DAY 36 value minus baseline\"\n))\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\"AVISIT_header\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb_f$AVISIT)\n  ) %&gt;%\n  summarize_change(\n    \"CHG\",\n    variables = list(value = \"AVAL\", baseline_flag = \"ABLFLL\"),\n    na.rm = TRUE\n  )\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adlb_f,\n  alt_counts_df = adsl\n)\n\nresult\n\nAnalysis Visit                        A: Drug X      B: Placebo    C: Combination\n                                       (N=134)        (N=134)         (N=132)    \n—————————————————————————————————————————————————————————————————————————————————\nBASELINE                                                                         \n  n                                      134            134             132      \n  Mean (SD)                          9.06 (0.93)    8.99 (0.98)     8.98 (0.89)  \n  Median                                 9.07           8.92            8.96     \n  Min - Max                          6.21 - 11.87   6.23 - 11.63    6.24 - 11.18 \nWEEK 1 DAY 8 value minus baseline                                                \n  n                                      134             0              132      \n  Mean (SD)                          -0.05 (1.38)        NA         -0.02 (1.30) \n  Median                                -0.17            NA             0.02     \n  Min - Max                          -3.56 - 3.48        NA         -3.28 - 3.33 \nWEEK 2 DAY 15 value minus baseline                                               \n  n                                      134            134             132      \n  Mean (SD)                          -0.19 (1.47)   0.01 (1.45)     0.15 (1.25)  \n  Median                                -0.27          -0.00            0.15     \n  Min - Max                          -4.53 - 4.45   -3.79 - 3.43    -2.92 - 3.28 \nWEEK 3 DAY 22 value minus baseline                                               \n  n                                      134            134             132      \n  Mean (SD)                          0.03 (1.38)    -0.02 (1.49)    0.02 (1.34)  \n  Median                                 0.15          -0.04            0.20     \n  Min - Max                          -3.95 - 2.99   -4.28 - 4.24    -2.76 - 3.26 \nWEEK 4 DAY 29 value minus baseline                                               \n  n                                      134            134             132      \n  Mean (SD)                          -0.26 (1.45)   0.05 (1.24)     -0.01 (1.17) \n  Median                                -0.37           0.10           -0.06     \n  Min - Max                          -3.74 - 4.15   -3.34 - 3.71    -3.06 - 3.22 \nWEEK 5 DAY 36 value minus baseline                                               \n  n                                      134            134             132      \n  Mean (SD)                          -0.02 (1.50)   0.07 (1.34)     0.03 (1.27)  \n  Median                                 0.01           0.15            0.05     \n  Min - Max                          -4.15 - 3.96   -3.50 - 3.53    -3.63 - 4.78 \n\n\n\n\nHere, we pre-process and manually define the variable “Baseline or Absolute Change from Baseline”.\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))\nadlb &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adlb\")) %&gt;%\n  filter(\n    !(ARM == \"B: Placebo\" & AVISIT == \"WEEK 1 DAY 8\"),\n    AVISIT != \"SCREENING\"\n  ) %&gt;%\n  dplyr::mutate(\n    AVISIT = droplevels(AVISIT),\n    ABLFLL = ABLFL == \"Y\",\n    AVISIT_header = recode(AVISIT,\n      \"BASELINE\" = \"BASELINE\",\n      \"WEEK 1 DAY 8\" = \"WEEK 1 DAY 8 value minus baseline\",\n      \"WEEK 2 DAY 15\" = \"WEEK 2 DAY 15 value minus baseline\",\n      \"WEEK 3 DAY 22\" = \"WEEK 3 DAY 22 value minus baseline\",\n      \"WEEK 4 DAY 29\" = \"WEEK 4 DAY 29 value minus baseline\",\n      \"WEEK 5 DAY 36\" = \"WEEK 5 DAY 36 value minus baseline\"\n    )\n  ) %&gt;%\n  dplyr::group_by(USUBJID, PARAM) %&gt;%\n  dplyr::mutate(\n    AVAL_CHG = AVAL - (!ABLFLL) * sum(AVAL * ABLFLL)\n  ) %&gt;%\n  dplyr::ungroup() %&gt;%\n  var_relabel(\n    AVAL_CHG = \"Baseline or Absolute Change from Baseline\",\n    ABLFLL = \"Baseline Flag (TRUE/FALSE)\",\n    AVISIT_header = \"Analysis Visit\"\n  )\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADLB\", adlb, code = '\n                  ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adlb\")) %&gt;%\n                  filter(\n                    !(ARM == \"B: Placebo\" & AVISIT == \"WEEK 1 DAY 8\"),\n                    AVISIT != \"SCREENING\"\n                  ) %&gt;%\n                  dplyr::mutate(\n                    AVISIT = droplevels(AVISIT),\n                    ABLFLL = ABLFL == \"Y\",\n                    AVISIT_header = recode(AVISIT,\n                           \"BASELINE\" = \"BASELINE\",\n                           \"WEEK 1 DAY 8\" = \"WEEK 1 DAY 8 value minus baseline\",\n                           \"WEEK 2 DAY 15\" = \"WEEK 2 DAY 15 value minus baseline\",\n                           \"WEEK 3 DAY 22\" = \"WEEK 3 DAY 22 value minus baseline\",\n                           \"WEEK 4 DAY 29\" = \"WEEK 4 DAY 29 value minus baseline\",\n                           \"WEEK 5 DAY 36\" = \"WEEK 5 DAY 36 value minus baseline\"\n                           )\n                  ) %&gt;%\n                  dplyr::group_by(USUBJID, PARAM) %&gt;%\n                  dplyr::mutate(\n                    AVAL_CHG = AVAL - (!ABLFLL) * sum(AVAL * ABLFLL)\n                  ) %&gt;%\n                  dplyr::ungroup()  %&gt;%\n                  var_relabel(\n                    AVAL_CHG = \"Baseline or Absolute Change from Baseline\",\n                    ABLFLL = \"Baseline Flag (TRUE/FALSE)\",\n                    AVISIT_header = \"Analysis Visit\"\n                  )'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Laboratory Test Results Change from Baseline by Visit\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"PARAM\", \"AVISIT_header\")), # note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`\n        selected = c(\"PARAM\", \"AVISIT_header\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"AVAL\", \"CHG\", \"AVAL_CHG\")),\n        selected = c(\"AVAL_CHG\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = \"CRP\"\n      )\n    )\n  ),\n  filter = list(ADLB = list(AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:30:04.6421 pid:12583 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt07.html",
+    "href": "tables/lab-results/lbt07.html",
+    "title": "LBT07",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\nlibrary(forcats)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_labels &lt;- var_labels(adlb)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\n# Select worst post-baseline records.\nadlb_f &lt;- adlb %&gt;%\n  filter(ATOXGR != \"&lt;Missing&gt;\") %&gt;%\n  filter(ONTRTFL == \"Y\") %&gt;%\n  filter(WGRLOFL == \"Y\" | WGRHIFL == \"Y\")\n\nvar_labels(adlb_f) &lt;- adlb_labels\n\n# Derive GRADE_DIR and GRADE_ANL to use in layout from ATOXGR\nadlb_f &lt;- adlb_f %&gt;%\n  mutate(\n    GRADE_DIR = factor(\n      case_when(\n        ATOXGR %in% c(\"-1\", \"-2\", \"-3\", \"-4\") & .data$WGRLOFL == \"Y\" ~ \"LOW\",\n        ATOXGR == \"0\" ~ \"ZERO\",\n        ATOXGR %in% c(\"1\", \"2\", \"3\", \"4\") & .data$WGRHIFL == \"Y\" ~ \"HIGH\",\n        TRUE ~ \"NONE\"\n      ),\n      levels = c(\"LOW\", \"ZERO\", \"HIGH\", \"NONE\")\n    ),\n    GRADE_ANL = forcats::fct_relevel(\n      forcats::fct_recode(ATOXGR,\n        `1` = \"-1\", `2` = \"-2\", `3` = \"-3\", `4` = \"-4\"\n      ),\n      c(\"0\", \"1\", \"2\", \"3\", \"4\")\n    )\n  ) %&gt;%\n  var_relabel(\n    GRADE_DIR = \"Direction of Abnormality\",\n    GRADE_ANL = \"Analysis Grade\"\n  )\n\n# Construct analysis map\nmap &lt;- expand.grid(\n  PARAM = levels(adlb$PARAM),\n  GRADE_DIR = c(\"LOW\", \"HIGH\"),\n  GRADE_ANL = as.character(1:4),\n  stringsAsFactors = FALSE\n) %&gt;%\n  arrange(PARAM, desc(GRADE_DIR), GRADE_ANL)\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb_f$PARAM)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    required = \"ATOXGR\",\n    .stats = \"unique_count\"\n  ) %&gt;%\n  split_rows_by(\n    \"GRADE_DIR\",\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb_f$GRADE_DIR),\n    split_fun = trim_levels_to_map(map)\n  ) %&gt;%\n  count_abnormal_by_worst_grade(\n    var = \"GRADE_ANL\",\n    variables = list(id = \"USUBJID\", param = \"PARAM\", grade_dir = \"GRADE_DIR\"),\n    .indent_mods = 4L\n  ) %&gt;%\n  append_topleft(\"            Highest NCI CTCAE Grade\")\n\nresult &lt;- build_table(lyt = lyt, df = adlb_f, alt_counts_df = adsl)\nresult &lt;- result %&gt;% prune_table()\n\nresult\n\nParameter                                                                          \n  Direction of Abnormality                 A: Drug X    B: Placebo   C: Combination\n            Highest NCI CTCAE Grade         (N=134)      (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (n)      134          134            132      \n  LOW                                                                              \n            1                              15 (11.2%)   11 (8.2%)      15 (11.4%)  \n            2                              18 (13.4%)   24 (17.9%)     17 (12.9%)  \n            3                              16 (11.9%)   24 (17.9%)     16 (12.1%)  \n            4                              17 (12.7%)   10 (7.5%)      18 (13.6%)  \n            Any                            66 (49.3%)   69 (51.5%)      66 (50%)   \nC-Reactive Protein Measurement (n)            134          134            132      \n  LOW                                                                              \n            1                              21 (15.7%)   22 (16.4%)     12 (9.1%)   \n            2                              24 (17.9%)   22 (16.4%)     18 (13.6%)  \n            3                              29 (21.6%)   21 (15.7%)     25 (18.9%)  \n            4                              10 (7.5%)    16 (11.9%)     22 (16.7%)  \n            Any                            84 (62.7%)   81 (60.4%)     77 (58.3%)  \n  HIGH                                                                             \n            1                              20 (14.9%)   22 (16.4%)     22 (16.7%)  \n            2                              21 (15.7%)   15 (11.2%)     14 (10.6%)  \n            3                              25 (18.7%)   16 (11.9%)     20 (15.2%)  \n            4                              13 (9.7%)    20 (14.9%)     11 (8.3%)   \n            Any                             79 (59%)    73 (54.5%)     67 (50.8%)  \nImmunoglobulin A Measurement (n)              134          134            132      \n  HIGH                                                                             \n            1                              19 (14.2%)    12 (9%)       18 (13.6%)  \n            2                              17 (12.7%)   24 (17.9%)     19 (14.4%)  \n            3                              21 (15.7%)   23 (17.2%)     23 (17.4%)  \n            4                              13 (9.7%)    13 (9.7%)       9 (6.8%)   \n            Any                            70 (52.2%)   72 (53.7%)     69 (52.3%)  \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  filter(!AVISIT %in% c(\"SCREENING\", \"BASELINE\"))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", adlb,\n      code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n    filter(!AVISIT %in% c(\"SCREENING\", \"BASELINE\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_abnormality_by_worst_grade(\n      label = \"Laboratory Test Results with Highest Grade Post-Baseline\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = c(\"ALT\", \"CRP\", \"IGA\")\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = (\n    list(\n      ADSL = list(SAFFL = \"Y\"),\n      ADLB = list(ONTRTFL = \"Y\")\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:28:45.3840 pid:12387 token:[] teal.modules.clinical Initializing tm_t_abnormality_by_worst_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] forcats_1.0.0                dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt12.html",
+    "href": "tables/lab-results/lbt12.html",
+    "title": "LBT12",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadhy &lt;- synthetic_cdisc_dataset(\"latest\", \"adhy\")\n\nanl &lt;- adhy\nanl$APERIODC &lt;- as.factor(anl$APERIODC) # to ensure the table is built even if there is no patients after filtering\nanl$ACTARM &lt;- as.factor(anl$ACTARM) # to ensure the table is built even if there is no patients after filtering\n\nanl &lt;- anl %&gt;%\n  filter(\n    SAFFL == \"Y\",\n    PARAMCD %in% c(\"ASTPULN\", \"ALTPULN\", \"ALTASTPU\") & AVISIT == \"POST-BASELINE\"\n  ) %&gt;%\n  mutate(\n    ARM_AVALC = factor(\n      case_when(\n        AVALC == \"Y\" ~ as.character(ACTARM),\n        TRUE ~ \"Criteria not met\"\n      ),\n      levels = c(levels(anl$ACTARM), \"Criteria not met\")\n    ),\n    PARAM = factor(\n      case_when(\n        PARAMCD == \"ASTPULN\" ~ \"AST &gt;3x ULN\",\n        PARAMCD == \"ALTPULN\" ~ \"ALT &gt;3x ULN\",\n        PARAMCD == \"ALTASTPU\" ~ \"AST &gt;3x ULN or ALT &gt;x3 ULN\"\n      ),\n      levels = c(\"AST &gt;3x ULN\", \"ALT &gt;3x ULN\", \"AST &gt;3x ULN or ALT &gt;x3 ULN\")\n    ),\n    TITLE = factor(\"First Elevated Result Occurring During\")\n  )\n\nanl &lt;- df_explicit_na(anl)\n\n\n\n\n\nCoderesult &lt;- basic_table() %&gt;%\n  split_cols_by(\"TITLE\") %&gt;%\n  split_cols_by(\"APERIODC\") %&gt;%\n  split_rows_by(\"PARAM\") %&gt;%\n  split_rows_by(\"ACTARM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\"ARM_AVALC\", .stats = \"fraction\", denom = \"n\", drop = TRUE) %&gt;%\n  build_table(anl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  dplyr::if_else(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- result %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                              First Elevated Result Occurring During  \n                                  PERIOD 1              PERIOD 2      \n——————————————————————————————————————————————————————————————————————\nAST &gt;3x ULN                                                           \n  A: Drug X                     11/134 (8.2%)        21/134 (15.7%)   \n  B: Placebo                   17/134 (12.7%)        16/134 (11.9%)   \n  C: Combination                10/132 (7.6%)         8/132 (6.1%)    \nALT &gt;3x ULN                                                           \n  A: Drug X                    14/134 (10.4%)         8/134 (6.0%)    \n  B: Placebo                   24/134 (17.9%)        18/134 (13.4%)   \n  C: Combination               16/132 (12.1%)         10/132 (7.6%)   \nAST &gt;3x ULN or ALT &gt;x3 ULN                                            \n  A: Drug X                    14/134 (10.4%)        15/134 (11.2%)   \n  B: Placebo                    8/134 (6.0%)          13/134 (9.7%)   \n  C: Combination                11/132 (8.3%)         12/132 (9.1%)   \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt13.html",
+    "href": "tables/lab-results/lbt13.html",
+    "title": "LBT13",
+    "section": "",
+    "text": "Data Setup\nStandard Table (Low)\nStandard Table (High)\nTable Without Patients with  Missing Baseline (Low)\nTable with Missing Baseline  Considered as Grade 0 (High)\nTable with Fill-In  of Grades (High)\nteal App\nReproducibility\n\n\n\nPlease note that for each variant, the adlb dataset needs to be filtered on correct flags like WGRLOVFL, WGRHIVFL, et al., otherwise the layout function will not return the correct counts. There is an option to create a record for a lab test where no record is found at that visit. If you specified add_derived_type = \"PHANTOM\" & dtype_phantom_cond, you don’t have to use the h_adsl_adlb_merge_using_worst_flag function to preprocess your adlb dataset. Otherwise please follow the pre-processing steps below before applying the layout functions.\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\n# Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be\n# selected properly.\nadsl_f &lt;- adsl %&gt;% filter(SAFFL == \"Y\")\nadlb &lt;- adlb %&gt;% filter(PARAMCD == \"CRP\" & SAFFL == \"Y\")\n\n\n\n\nNote that the worst laboratory flag (below WGRLOVFL) must be selected appropriately to match the direction of abnormality (here Low). New grouping variables ATOXGR_GP and BTOXGR_GP are created to display the correct output.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRLOVFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- adsl_f %&gt;%\n  h_adsl_adlb_merge_using_worst_flag(\n    adlb_f,\n    worst_flag = c(\"WGRLOVFL\" = \"Y\"),\n    by_visit = TRUE,\n    no_fillin_visits = c(\"SCREENING\", \"BASELINE\", \"UNSCHEDULED\")\n  )\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = case_when(\n      ATOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      ATOXGR == -1 ~ \"1\",\n      ATOXGR == -2 ~ \"2\",\n      ATOXGR == -3 ~ \"3\",\n      ATOXGR == -4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = case_when(\n      BTOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      BTOXGR == -1 ~ \"1\",\n      BTOXGR == -2 ~ \"2\",\n      BTOXGR == -3 ~ \"3\",\n      BTOXGR == -4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  )\n\nadlb_out &lt;- adlb_out %&gt;% mutate(\n  AVISIT = forcats::fct_reorder(AVISIT, AVISITN),\n  ATOXGR_GP = factor(ATOXGR_GP, levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n  BTOXGR_GP = factor(BTOXGR_GP, levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n)\n\nadlb_out &lt;- adlb_out %&gt;%\n  var_relabel(\n    PARAMCD = \"Parameter Code\",\n    AVISIT = \"Visit\",\n    ATOXGR_GP = \"NCI CTCAE Grade at Visit\",\n    BTOXGR_GP = \"Baseline NCI CTCAE Grade\"\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAMCD\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$PARAMCD)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$AVISIT)\n  ) %&gt;%\n  split_rows_by(\n    \"ATOXGR_GP\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$ATOXGR_GP)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\")) %&gt;%\n  count_occurrences(\"BTOXGR_GP\", denom = \"n\", drop = TRUE) %&gt;%\n  append_varlabels(adlb_out, \"BTOXGR_GP\", indent = 3L) %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter Code                                                             \n  Visit                                                                    \n    NCI CTCAE Grade at Visit      A: Drug X    B: Placebo    C: Combination\n      Baseline NCI CTCAE Grade     (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————\nCRP                                                                        \n  WEEK 1 DAY 8                                                             \n    Not Low (n)                      116           110            101      \n      Not Low                    103 (88.8%)   91 (82.7%)      88 (87.1%)  \n      1                           3 (2.6%)      5 (4.5%)        6 (5.9%)   \n      2                           4 (3.4%)      9 (8.2%)        2 (2.0%)   \n      3                           3 (2.6%)      4 (3.6%)        4 (4.0%)   \n      4                           3 (2.6%)      1 (0.9%)        1 (1.0%)   \n    1 (n)                             4             7              5       \n      Not Low                     3 (75.0%)     7 (100%)       4 (80.0%)   \n      3                           1 (25.0%)         0          1 (20.0%)   \n    2 (n)                             5             6              11      \n      Not Low                     5 (100%)      5 (83.3%)      8 (72.7%)   \n      1                               0             0           1 (9.1%)   \n      3                               0             0          2 (18.2%)   \n      4                               0         1 (16.7%)          0       \n    3 (n)                             6             8              5       \n      Not Low                     6 (100%)      7 (87.5%)       5 (100%)   \n      3                               0         1 (12.5%)          0       \n    4 (n)                             3             3              10      \n      Not Low                     2 (66.7%)     3 (100%)       7 (70.0%)   \n      1                               0             0          2 (20.0%)   \n      2                           1 (33.3%)         0              0       \n      4                               0             0          1 (10.0%)   \n  WEEK 2 DAY 15                                                            \n    Not Low (n)                      106           111            116      \n      Not Low                    93 (87.7%)    93 (83.8%)     100 (86.2%)  \n      1                           3 (2.8%)      4 (3.6%)        8 (6.9%)   \n      2                           5 (4.7%)      7 (6.3%)        2 (1.7%)   \n      3                           2 (1.9%)      5 (4.5%)        6 (5.2%)   \n      4                           3 (2.8%)      2 (1.8%)           0       \n    1 (n)                            15             9              2       \n      Not Low                    13 (86.7%)     8 (88.9%)      1 (50.0%)   \n      2                               0         1 (11.1%)          0       \n      3                           2 (13.3%)         0              0       \n      4                               0             0          1 (50.0%)   \n    2 (n)                             3             3              6       \n      Not Low                     3 (100%)      3 (100%)       4 (66.7%)   \n      1                               0             0          1 (16.7%)   \n      3                               0             0          1 (16.7%)   \n    3 (n)                             7             7              6       \n      Not Low                     7 (100%)      6 (85.7%)      5 (83.3%)   \n      2                               0         1 (14.3%)          0       \n      4                               0             0          1 (16.7%)   \n    4 (n)                             3             4              2       \n      Not Low                     3 (100%)      3 (75.0%)       2 (100%)   \n      1                               0         1 (25.0%)          0       \n  WEEK 3 DAY 22                                                            \n    Not Low (n)                      119           110            114      \n      Not Low                    104 (87.4%)   92 (83.6%)      94 (82.5%)  \n      1                           3 (2.5%)      4 (3.6%)        9 (7.9%)   \n      2                           5 (4.2%)      7 (6.4%)        2 (1.8%)   \n      3                           4 (3.4%)      5 (4.5%)        7 (6.1%)   \n      4                           3 (2.5%)      2 (1.8%)        2 (1.8%)   \n    1 (n)                             9             9              6       \n      Not Low                     9 (100%)      7 (77.8%)       6 (100%)   \n      2                               0         2 (22.2%)          0       \n    2 (n)                             1             7              3       \n      Not Low                     1 (100%)      6 (85.7%)       3 (100%)   \n      1                               0         1 (14.3%)          0       \n    3 (n)                             4             5              4       \n      Not Low                     4 (100%)      5 (100%)        4 (100%)   \n    4 (n)                             1             3              5       \n      Not Low                     1 (100%)      3 (100%)        5 (100%)   \n  WEEK 4 DAY 29                                                            \n    Not Low (n)                      101           119            111      \n      Not Low                    89 (88.1%)    100 (84.0%)     96 (86.5%)  \n      1                           3 (3.0%)      4 (3.4%)        6 (5.4%)   \n      2                           4 (4.0%)      8 (6.7%)        1 (0.9%)   \n      3                           2 (2.0%)      5 (4.2%)        6 (5.4%)   \n      4                           3 (3.0%)      2 (1.7%)        2 (1.8%)   \n    1 (n)                            10             5              6       \n      Not Low                     9 (90.0%)     5 (100%)       5 (83.3%)   \n      1                               0             0          1 (16.7%)   \n      2                           1 (10.0%)         0              0       \n    2 (n)                            13             4              6       \n      Not Low                     13 (100%)     3 (75.0%)      5 (83.3%)   \n      1                               0             0          1 (16.7%)   \n      2                               0         1 (25.0%)          0       \n    3 (n)                             8             2              6       \n      Not Low                     6 (75.0%)     1 (50.0%)      5 (83.3%)   \n      1                               0         1 (50.0%)          0       \n      2                               0             0          1 (16.7%)   \n      3                           2 (25.0%)         0              0       \n    4 (n)                             2             4              3       \n      Not Low                     2 (100%)      4 (100%)       1 (33.3%)   \n      1                               0             0          1 (33.3%)   \n      3                               0             0          1 (33.3%)   \n  WEEK 5 DAY 36                                                            \n    Not Low (n)                      115           112            111      \n      Not Low                    102 (88.7%)   94 (83.9%)      96 (86.5%)  \n      1                           2 (1.7%)      4 (3.6%)        6 (5.4%)   \n      2                           5 (4.3%)      7 (6.2%)        2 (1.8%)   \n      3                           3 (2.6%)      5 (4.5%)        5 (4.5%)   \n      4                           3 (2.6%)      2 (1.8%)        2 (1.8%)   \n    1 (n)                             5             7              6       \n      Not Low                     5 (100%)      4 (57.1%)      5 (83.3%)   \n      1                               0         1 (14.3%)      1 (16.7%)   \n      2                               0         2 (28.6%)          0       \n    2 (n)                             5            11              6       \n      Not Low                     5 (100%)      11 (100%)       6 (100%)   \n    3 (n)                             8             2              7       \n      Not Low                     6 (75.0%)     2 (100%)       4 (57.1%)   \n      1                           1 (12.5%)         0          1 (14.3%)   \n      3                           1 (12.5%)         0          2 (28.6%)   \n    4 (n)                             1             2              2       \n      Not Low                     1 (100%)      2 (100%)       1 (50.0%)   \n      1                               0             0          1 (50.0%)   \n\n\n\n\nNote that the worst laboratory flag (below WGRHIVFL) must be selected appropriately to match the direction of abnormality (here High). New grouping variables ATOXGR_GP and BTOXGR_GP are created to display the correct output.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIVFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- adsl_f %&gt;%\n  h_adsl_adlb_merge_using_worst_flag(\n    adlb_f,\n    worst_flag = c(\"WGRHIVFL\" = \"Y\"),\n    by_visit = TRUE,\n    no_fillin_visits = c(\"SCREENING\", \"BASELINE\", \"UNSCHEDULED\")\n  )\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  )\n\nadlb_out &lt;- adlb_out %&gt;% mutate(\n  AVISIT = forcats::fct_reorder(AVISIT, AVISITN),\n  ATOXGR_GP = factor(ATOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n  BTOXGR_GP = factor(BTOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n)\n\nadlb_out &lt;- adlb_out %&gt;%\n  var_relabel(\n    PARAMCD = \"Parameter Code\",\n    AVISIT = \"Visit\",\n    ATOXGR_GP = \"NCI CTCAE Grade at Visit\",\n    BTOXGR_GP = \"Baseline NCI CTCAE Grade\"\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAMCD\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$PARAMCD)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$AVISIT)\n  ) %&gt;%\n  split_rows_by(\n    \"ATOXGR_GP\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$ATOXGR_GP)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\")) %&gt;%\n  count_occurrences(\"BTOXGR_GP\", denom = \"n\", drop = TRUE) %&gt;%\n  append_varlabels(adlb_out, \"BTOXGR_GP\", indent = 3L) %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter Code                                                            \n  Visit                                                                   \n    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination\n      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————\nCRP                                                                       \n  WEEK 1 DAY 8                                                            \n    Not High (n)                    111           110            112      \n      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  \n      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   \n      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   \n      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   \n      4                           2 (1.8%)     2 (1.8%)           0       \n    1 (n)                            8            11              6       \n      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   \n      3                          1 (12.5%)         0          1 (16.7%)   \n    2 (n)                            6             4              5       \n      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   \n      1                              0         3 (75.0%)      1 (20.0%)   \n    3 (n)                            8             3              4       \n      Not High                   7 (87.5%)     3 (100%)        4 (100%)   \n      4                          1 (12.5%)         0              0       \n    4 (n)                            1             6              5       \n      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   \n      1                              0             0          1 (20.0%)   \n      3                              0         1 (16.7%)          0       \n  WEEK 2 DAY 15                                                           \n    Not High (n)                    117           113            113      \n      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  \n      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   \n      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   \n      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   \n      4                           3 (2.6%)     2 (1.8%)           0       \n    1 (n)                            6             9              7       \n      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   \n      1                              0         1 (11.1%)          0       \n      2                              0             0          1 (14.3%)   \n      3                          1 (16.7%)         0              0       \n    2 (n)                            4             4              6       \n      Not High                    4 (100%)     4 (100%)       3 (50.0%)   \n      1                              0             0          3 (50.0%)   \n    3 (n)                            5             3              5       \n      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   \n      1                          1 (20.0%)     1 (33.3%)          0       \n    4 (n)                            2             5              1       \n      Not High                    2 (100%)     3 (60.0%)       1 (100%)   \n      1                              0         2 (40.0%)          0       \n  WEEK 3 DAY 22                                                           \n    Not High (n)                    110           111            114      \n      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  \n      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   \n      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   \n      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n    1 (n)                            7             8              7       \n      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   \n      1                              0         1 (12.5%)          0       \n      2                              0         1 (12.5%)      1 (14.3%)   \n      3                              0         1 (12.5%)          0       \n    2 (n)                            9             7              5       \n      Not High                    9 (100%)     6 (85.7%)       5 (100%)   \n      3                              0         1 (14.3%)          0       \n    3 (n)                            6             3              4       \n      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   \n      3                          1 (16.7%)         0              0       \n      4                              0         1 (33.3%)          0       \n    4 (n)                            2             5              2       \n      Not High                   1 (50.0%)     5 (100%)        2 (100%)   \n      3                          1 (50.0%)         0              0       \n  WEEK 4 DAY 29                                                           \n    Not High (n)                    115           117            113      \n      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  \n      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   \n      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   \n      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   \n      4                           1 (0.9%)         0              0       \n    1 (n)                            4             3              11      \n      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  \n      2                              0             0           1 (9.1%)   \n      4                              0         1 (33.3%)          0       \n    2 (n)                            6             4              2       \n      Not High                    6 (100%)     3 (75.0%)       2 (100%)   \n      1                              0         1 (25.0%)          0       \n    3 (n)                            6             7              4       \n      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   \n      1                              0         1 (14.3%)          0       \n      3                              0         1 (14.3%)          0       \n      4                          1 (16.7%)     1 (14.3%)          0       \n    4 (n)                            3             3              2       \n      Not High                   2 (66.7%)     2 (66.7%)          0       \n      1                              0         1 (33.3%)      1 (50.0%)   \n      2                              0             0          1 (50.0%)   \n      4                          1 (33.3%)         0              0       \n  WEEK 5 DAY 36                                                           \n    Not High (n)                    111           111            119      \n      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  \n      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   \n      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   \n      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n    1 (n)                            8            11              5       \n      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   \n      1                              0         1 (9.1%)           0       \n      2                              0             0          1 (20.0%)   \n      3                          1 (12.5%)     1 (9.1%)           0       \n    2 (n)                            7             6              3       \n      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   \n      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   \n      2                          1 (14.3%)     1 (16.7%)          0       \n      4                              0         1 (16.7%)          0       \n    3 (n)                            3             3              4       \n      Not High                    3 (100%)     3 (100%)        4 (100%)   \n    4 (n)                            5             3              1       \n      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   \n      1                          1 (20.0%)         0              0       \n      3                              0         1 (33.3%)          0       \n\n\n\n\nNote that missing baseline values are filtered out in the pre-processing step.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRLOVFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- adsl_f %&gt;%\n  h_adsl_adlb_merge_using_worst_flag(\n    adlb_f,\n    worst_flag = c(\"WGRLOVFL\" = \"Y\"),\n    by_visit = TRUE,\n    no_fillin_visits = c(\"SCREENING\", \"BASELINE\", \"UNSCHEDULED\")\n  )\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  filter(BTOXGR != \"&lt;Missing&gt;\") %&gt;% # filter out missing baseline grade\n  mutate(\n    ATOXGR_GP = case_when(\n      ATOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      ATOXGR == -1 ~ \"1\",\n      ATOXGR == -2 ~ \"2\",\n      ATOXGR == -3 ~ \"3\",\n      ATOXGR == -4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = case_when(\n      BTOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      BTOXGR == -1 ~ \"1\",\n      BTOXGR == -2 ~ \"2\",\n      BTOXGR == -3 ~ \"3\",\n      BTOXGR == -4 ~ \"4\"\n    )\n  )\n\nadlb_out &lt;- adlb_out %&gt;% mutate(\n  AVISIT = forcats::fct_reorder(AVISIT, AVISITN),\n  ATOXGR_GP = factor(ATOXGR_GP, levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n  BTOXGR_GP = factor(BTOXGR_GP, levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\"))\n)\n\nadlb_out &lt;- adlb_out %&gt;%\n  var_relabel(\n    PARAMCD = \"Parameter Code\",\n    AVISIT = \"Visit\",\n    ATOXGR_GP = \"NCI CTCAE Grade at Visit\",\n    BTOXGR_GP = \"Baseline NCI CTCAE Grade\"\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAMCD\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$PARAMCD)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$AVISIT)\n  ) %&gt;%\n  split_rows_by(\n    \"ATOXGR_GP\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$ATOXGR_GP)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\")) %&gt;%\n  count_occurrences(\"BTOXGR_GP\", denom = \"n\", drop = TRUE) %&gt;%\n  append_varlabels(adlb_out, \"BTOXGR_GP\", indent = 3L) %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter Code                                                             \n  Visit                                                                    \n    NCI CTCAE Grade at Visit      A: Drug X    B: Placebo    C: Combination\n      Baseline NCI CTCAE Grade     (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————\nCRP                                                                        \n  WEEK 1 DAY 8                                                             \n    Not Low (n)                      116           110            101      \n      Not Low                    103 (88.8%)   91 (82.7%)      88 (87.1%)  \n      1                           3 (2.6%)      5 (4.5%)        6 (5.9%)   \n      2                           4 (3.4%)      9 (8.2%)        2 (2.0%)   \n      3                           3 (2.6%)      4 (3.6%)        4 (4.0%)   \n      4                           3 (2.6%)      1 (0.9%)        1 (1.0%)   \n    1 (n)                             4             7              5       \n      Not Low                     3 (75.0%)     7 (100%)       4 (80.0%)   \n      3                           1 (25.0%)         0          1 (20.0%)   \n    2 (n)                             5             6              11      \n      Not Low                     5 (100%)      5 (83.3%)      8 (72.7%)   \n      1                               0             0           1 (9.1%)   \n      3                               0             0          2 (18.2%)   \n      4                               0         1 (16.7%)          0       \n    3 (n)                             6             8              5       \n      Not Low                     6 (100%)      7 (87.5%)       5 (100%)   \n      3                               0         1 (12.5%)          0       \n    4 (n)                             3             3              10      \n      Not Low                     2 (66.7%)     3 (100%)       7 (70.0%)   \n      1                               0             0          2 (20.0%)   \n      2                           1 (33.3%)         0              0       \n      4                               0             0          1 (10.0%)   \n  WEEK 2 DAY 15                                                            \n    Not Low (n)                      106           111            116      \n      Not Low                    93 (87.7%)    93 (83.8%)     100 (86.2%)  \n      1                           3 (2.8%)      4 (3.6%)        8 (6.9%)   \n      2                           5 (4.7%)      7 (6.3%)        2 (1.7%)   \n      3                           2 (1.9%)      5 (4.5%)        6 (5.2%)   \n      4                           3 (2.8%)      2 (1.8%)           0       \n    1 (n)                            15             9              2       \n      Not Low                    13 (86.7%)     8 (88.9%)      1 (50.0%)   \n      2                               0         1 (11.1%)          0       \n      3                           2 (13.3%)         0              0       \n      4                               0             0          1 (50.0%)   \n    2 (n)                             3             3              6       \n      Not Low                     3 (100%)      3 (100%)       4 (66.7%)   \n      1                               0             0          1 (16.7%)   \n      3                               0             0          1 (16.7%)   \n    3 (n)                             7             7              6       \n      Not Low                     7 (100%)      6 (85.7%)      5 (83.3%)   \n      2                               0         1 (14.3%)          0       \n      4                               0             0          1 (16.7%)   \n    4 (n)                             3             4              2       \n      Not Low                     3 (100%)      3 (75.0%)       2 (100%)   \n      1                               0         1 (25.0%)          0       \n  WEEK 3 DAY 22                                                            \n    Not Low (n)                      119           110            114      \n      Not Low                    104 (87.4%)   92 (83.6%)      94 (82.5%)  \n      1                           3 (2.5%)      4 (3.6%)        9 (7.9%)   \n      2                           5 (4.2%)      7 (6.4%)        2 (1.8%)   \n      3                           4 (3.4%)      5 (4.5%)        7 (6.1%)   \n      4                           3 (2.5%)      2 (1.8%)        2 (1.8%)   \n    1 (n)                             9             9              6       \n      Not Low                     9 (100%)      7 (77.8%)       6 (100%)   \n      2                               0         2 (22.2%)          0       \n    2 (n)                             1             7              3       \n      Not Low                     1 (100%)      6 (85.7%)       3 (100%)   \n      1                               0         1 (14.3%)          0       \n    3 (n)                             4             5              4       \n      Not Low                     4 (100%)      5 (100%)        4 (100%)   \n    4 (n)                             1             3              5       \n      Not Low                     1 (100%)      3 (100%)        5 (100%)   \n  WEEK 4 DAY 29                                                            \n    Not Low (n)                      101           119            111      \n      Not Low                    89 (88.1%)    100 (84.0%)     96 (86.5%)  \n      1                           3 (3.0%)      4 (3.4%)        6 (5.4%)   \n      2                           4 (4.0%)      8 (6.7%)        1 (0.9%)   \n      3                           2 (2.0%)      5 (4.2%)        6 (5.4%)   \n      4                           3 (3.0%)      2 (1.7%)        2 (1.8%)   \n    1 (n)                            10             5              6       \n      Not Low                     9 (90.0%)     5 (100%)       5 (83.3%)   \n      1                               0             0          1 (16.7%)   \n      2                           1 (10.0%)         0              0       \n    2 (n)                            13             4              6       \n      Not Low                     13 (100%)     3 (75.0%)      5 (83.3%)   \n      1                               0             0          1 (16.7%)   \n      2                               0         1 (25.0%)          0       \n    3 (n)                             8             2              6       \n      Not Low                     6 (75.0%)     1 (50.0%)      5 (83.3%)   \n      1                               0         1 (50.0%)          0       \n      2                               0             0          1 (16.7%)   \n      3                           2 (25.0%)         0              0       \n    4 (n)                             2             4              3       \n      Not Low                     2 (100%)      4 (100%)       1 (33.3%)   \n      1                               0             0          1 (33.3%)   \n      3                               0             0          1 (33.3%)   \n  WEEK 5 DAY 36                                                            \n    Not Low (n)                      115           112            111      \n      Not Low                    102 (88.7%)   94 (83.9%)      96 (86.5%)  \n      1                           2 (1.7%)      4 (3.6%)        6 (5.4%)   \n      2                           5 (4.3%)      7 (6.2%)        2 (1.8%)   \n      3                           3 (2.6%)      5 (4.5%)        5 (4.5%)   \n      4                           3 (2.6%)      2 (1.8%)        2 (1.8%)   \n    1 (n)                             5             7              6       \n      Not Low                     5 (100%)      4 (57.1%)      5 (83.3%)   \n      1                               0         1 (14.3%)      1 (16.7%)   \n      2                               0         2 (28.6%)          0       \n    2 (n)                             5            11              6       \n      Not Low                     5 (100%)      11 (100%)       6 (100%)   \n    3 (n)                             8             2              7       \n      Not Low                     6 (75.0%)     2 (100%)       4 (57.1%)   \n      1                           1 (12.5%)         0          1 (14.3%)   \n      3                           1 (12.5%)         0          2 (28.6%)   \n    4 (n)                             1             2              2       \n      Not Low                     1 (100%)      2 (100%)       1 (50.0%)   \n      1                               0             0          1 (50.0%)   \n\n\n\n\nNote that when BTOXGR is missing, the grouping variable BTOXGR_GP is now \"Not High\" instead of \"Missing\" compared to Standard Table (High).\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIVFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- adsl_f %&gt;%\n  h_adsl_adlb_merge_using_worst_flag(\n    adlb_f,\n    worst_flag = c(\"WGRHIVFL\" = \"Y\"),\n    by_visit = TRUE,\n    no_fillin_visits = c(\"SCREENING\", \"BASELINE\", \"UNSCHEDULED\")\n  )\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4, \"&lt;Missing&gt;\") ~ \"Not High\", # Missing BTOXGR now grouped to \"Not High\"\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\"\n    )\n  )\n\nadlb_out &lt;- adlb_out %&gt;% mutate(\n  AVISIT = forcats::fct_reorder(AVISIT, AVISITN),\n  ATOXGR_GP = factor(ATOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n  BTOXGR_GP = factor(BTOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n)\n\nadlb_out &lt;- adlb_out %&gt;%\n  var_relabel(\n    PARAMCD = \"Parameter Code\",\n    AVISIT = \"Visit\",\n    ATOXGR_GP = \"NCI CTCAE Grade at Visit\",\n    BTOXGR_GP = \"Baseline NCI CTCAE Grade\"\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAMCD\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$PARAMCD)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$AVISIT)\n  ) %&gt;%\n  split_rows_by(\n    \"ATOXGR_GP\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$ATOXGR_GP)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\")) %&gt;%\n  count_occurrences(\"BTOXGR_GP\", denom = \"n\", drop = TRUE) %&gt;%\n  append_varlabels(adlb_out, \"BTOXGR_GP\", indent = 3L) %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter Code                                                            \n  Visit                                                                   \n    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination\n      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————\nCRP                                                                       \n  WEEK 1 DAY 8                                                            \n    Not High (n)                    111           110            112      \n      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  \n      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   \n      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   \n      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   \n      4                           2 (1.8%)     2 (1.8%)           0       \n    1 (n)                            8            11              6       \n      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   \n      3                          1 (12.5%)         0          1 (16.7%)   \n    2 (n)                            6             4              5       \n      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   \n      1                              0         3 (75.0%)      1 (20.0%)   \n    3 (n)                            8             3              4       \n      Not High                   7 (87.5%)     3 (100%)        4 (100%)   \n      4                          1 (12.5%)         0              0       \n    4 (n)                            1             6              5       \n      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   \n      1                              0             0          1 (20.0%)   \n      3                              0         1 (16.7%)          0       \n  WEEK 2 DAY 15                                                           \n    Not High (n)                    117           113            113      \n      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  \n      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   \n      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   \n      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   \n      4                           3 (2.6%)     2 (1.8%)           0       \n    1 (n)                            6             9              7       \n      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   \n      1                              0         1 (11.1%)          0       \n      2                              0             0          1 (14.3%)   \n      3                          1 (16.7%)         0              0       \n    2 (n)                            4             4              6       \n      Not High                    4 (100%)     4 (100%)       3 (50.0%)   \n      1                              0             0          3 (50.0%)   \n    3 (n)                            5             3              5       \n      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   \n      1                          1 (20.0%)     1 (33.3%)          0       \n    4 (n)                            2             5              1       \n      Not High                    2 (100%)     3 (60.0%)       1 (100%)   \n      1                              0         2 (40.0%)          0       \n  WEEK 3 DAY 22                                                           \n    Not High (n)                    110           111            114      \n      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  \n      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   \n      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   \n      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n    1 (n)                            7             8              7       \n      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   \n      1                              0         1 (12.5%)          0       \n      2                              0         1 (12.5%)      1 (14.3%)   \n      3                              0         1 (12.5%)          0       \n    2 (n)                            9             7              5       \n      Not High                    9 (100%)     6 (85.7%)       5 (100%)   \n      3                              0         1 (14.3%)          0       \n    3 (n)                            6             3              4       \n      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   \n      3                          1 (16.7%)         0              0       \n      4                              0         1 (33.3%)          0       \n    4 (n)                            2             5              2       \n      Not High                   1 (50.0%)     5 (100%)        2 (100%)   \n      3                          1 (50.0%)         0              0       \n  WEEK 4 DAY 29                                                           \n    Not High (n)                    115           117            113      \n      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  \n      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   \n      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   \n      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   \n      4                           1 (0.9%)         0              0       \n    1 (n)                            4             3              11      \n      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  \n      2                              0             0           1 (9.1%)   \n      4                              0         1 (33.3%)          0       \n    2 (n)                            6             4              2       \n      Not High                    6 (100%)     3 (75.0%)       2 (100%)   \n      1                              0         1 (25.0%)          0       \n    3 (n)                            6             7              4       \n      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   \n      1                              0         1 (14.3%)          0       \n      3                              0         1 (14.3%)          0       \n      4                          1 (16.7%)     1 (14.3%)          0       \n    4 (n)                            3             3              2       \n      Not High                   2 (66.7%)     2 (66.7%)          0       \n      1                              0         1 (33.3%)      1 (50.0%)   \n      2                              0             0          1 (50.0%)   \n      4                          1 (33.3%)         0              0       \n  WEEK 5 DAY 36                                                           \n    Not High (n)                    111           111            119      \n      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  \n      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   \n      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   \n      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n    1 (n)                            8            11              5       \n      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   \n      1                              0         1 (9.1%)           0       \n      2                              0             0          1 (20.0%)   \n      3                          1 (12.5%)     1 (9.1%)           0       \n    2 (n)                            7             6              3       \n      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   \n      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   \n      2                          1 (14.3%)     1 (16.7%)          0       \n      4                              0         1 (16.7%)          0       \n    3 (n)                            3             3              4       \n      Not High                    3 (100%)     3 (100%)        4 (100%)   \n    4 (n)                            5             3              1       \n      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   \n      1                          1 (20.0%)         0              0       \n      3                              0         1 (33.3%)          0       \n\n\n\n\nPre-processing is the same as for Standard Table (High), but in order to keep all levels, the drop argument in count_occurrences is set to FALSE.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIVFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- adsl_f %&gt;%\n  h_adsl_adlb_merge_using_worst_flag(\n    adlb_f,\n    worst_flag = c(\"WGRHIVFL\" = \"Y\"),\n    by_visit = TRUE,\n    no_fillin_visits = c(\"SCREENING\", \"BASELINE\", \"UNSCHEDULED\")\n  )\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    )\n  )\n\nadlb_out &lt;- adlb_out %&gt;% mutate(\n  AVISIT = forcats::fct_reorder(AVISIT, AVISITN),\n  ATOXGR_GP = factor(ATOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n  BTOXGR_GP = factor(BTOXGR_GP, levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n)\n\nadlb_out &lt;- adlb_out %&gt;%\n  var_relabel(\n    PARAMCD = \"Parameter Code\",\n    AVISIT = \"Visit\",\n    ATOXGR_GP = \"NCI CTCAE Grade at Visit\",\n    BTOXGR_GP = \"Baseline NCI CTCAE Grade\"\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAMCD\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$PARAMCD)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb_out$AVISIT)\n  ) %&gt;%\n  split_rows_by(\n    \"ATOXGR_GP\",\n    split_fun = keep_split_levels(c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\")),\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb_out$ATOXGR_GP)\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\")) %&gt;%\n  count_occurrences(\"BTOXGR_GP\", denom = \"n\", drop = FALSE) %&gt;%\n  append_varlabels(adlb_out, \"BTOXGR_GP\", indent = 3L) %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter Code                                                            \n  Visit                                                                   \n    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination\n      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————\nCRP                                                                       \n  WEEK 1 DAY 8                                                            \n    Not High (n)                    111           110            112      \n      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  \n      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   \n      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   \n      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   \n      4                           2 (1.8%)     2 (1.8%)           0       \n      Missing                        0             0              0       \n    1 (n)                            8            11              6       \n      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                          1 (12.5%)         0          1 (16.7%)   \n      4                              0             0              0       \n      Missing                        0             0              0       \n    2 (n)                            6             4              5       \n      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   \n      1                              0         3 (75.0%)      1 (20.0%)   \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    3 (n)                            8             3              4       \n      Not High                   7 (87.5%)     3 (100%)        4 (100%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                          1 (12.5%)         0              0       \n      Missing                        0             0              0       \n    4 (n)                            1             6              5       \n      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   \n      1                              0             0          1 (20.0%)   \n      2                              0             0              0       \n      3                              0         1 (16.7%)          0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    Missing (n)                      0             0              0       \n      Not High                       0             0              0       \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n  WEEK 2 DAY 15                                                           \n    Not High (n)                    117           113            113      \n      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  \n      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   \n      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   \n      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   \n      4                           3 (2.6%)     2 (1.8%)           0       \n      Missing                        0             0              0       \n    1 (n)                            6             9              7       \n      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   \n      1                              0         1 (11.1%)          0       \n      2                              0             0          1 (14.3%)   \n      3                          1 (16.7%)         0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    2 (n)                            4             4              6       \n      Not High                    4 (100%)     4 (100%)       3 (50.0%)   \n      1                              0             0          3 (50.0%)   \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    3 (n)                            5             3              5       \n      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   \n      1                          1 (20.0%)     1 (33.3%)          0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    4 (n)                            2             5              1       \n      Not High                    2 (100%)     3 (60.0%)       1 (100%)   \n      1                              0         2 (40.0%)          0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    Missing (n)                      0             0              0       \n      Not High                       0             0              0       \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n  WEEK 3 DAY 22                                                           \n    Not High (n)                    110           111            114      \n      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  \n      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   \n      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   \n      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n      Missing                        0             0              0       \n    1 (n)                            7             8              7       \n      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   \n      1                              0         1 (12.5%)          0       \n      2                              0         1 (12.5%)      1 (14.3%)   \n      3                              0         1 (12.5%)          0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    2 (n)                            9             7              5       \n      Not High                    9 (100%)     6 (85.7%)       5 (100%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0         1 (14.3%)          0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    3 (n)                            6             3              4       \n      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                          1 (16.7%)         0              0       \n      4                              0         1 (33.3%)          0       \n      Missing                        0             0              0       \n    4 (n)                            2             5              2       \n      Not High                   1 (50.0%)     5 (100%)        2 (100%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                          1 (50.0%)         0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    Missing (n)                      0             0              0       \n      Not High                       0             0              0       \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n  WEEK 4 DAY 29                                                           \n    Not High (n)                    115           117            113      \n      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  \n      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   \n      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   \n      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   \n      4                           1 (0.9%)         0              0       \n      Missing                        0             0              0       \n    1 (n)                            4             3              11      \n      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  \n      1                              0             0              0       \n      2                              0             0           1 (9.1%)   \n      3                              0             0              0       \n      4                              0         1 (33.3%)          0       \n      Missing                        0             0              0       \n    2 (n)                            6             4              2       \n      Not High                    6 (100%)     3 (75.0%)       2 (100%)   \n      1                              0         1 (25.0%)          0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    3 (n)                            6             7              4       \n      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   \n      1                              0         1 (14.3%)          0       \n      2                              0             0              0       \n      3                              0         1 (14.3%)          0       \n      4                          1 (16.7%)     1 (14.3%)          0       \n      Missing                        0             0              0       \n    4 (n)                            3             3              2       \n      Not High                   2 (66.7%)     2 (66.7%)          0       \n      1                              0         1 (33.3%)      1 (50.0%)   \n      2                              0             0          1 (50.0%)   \n      3                              0             0              0       \n      4                          1 (33.3%)         0              0       \n      Missing                        0             0              0       \n    Missing (n)                      0             0              0       \n      Not High                       0             0              0       \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n  WEEK 5 DAY 36                                                           \n    Not High (n)                    111           111            119      \n      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  \n      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   \n      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   \n      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   \n      4                           3 (2.7%)     1 (0.9%)           0       \n      Missing                        0             0              0       \n    1 (n)                            8            11              5       \n      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   \n      1                              0         1 (9.1%)           0       \n      2                              0             0          1 (20.0%)   \n      3                          1 (12.5%)     1 (9.1%)           0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    2 (n)                            7             6              3       \n      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   \n      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   \n      2                          1 (14.3%)     1 (16.7%)          0       \n      3                              0             0              0       \n      4                              0         1 (16.7%)          0       \n      Missing                        0             0              0       \n    3 (n)                            3             3              4       \n      Not High                    3 (100%)     3 (100%)        4 (100%)   \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    4 (n)                            5             3              1       \n      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   \n      1                          1 (20.0%)         0              0       \n      2                              0             0              0       \n      3                              0         1 (33.3%)          0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n    Missing (n)                      0             0              0       \n      Not High                       0             0              0       \n      1                              0             0              0       \n      2                              0             0              0       \n      3                              0             0              0       \n      4                              0             0              0       \n      Missing                        0             0              0       \n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", adlb,\n      code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_shift_by_grade(\n      label = \"Grade Laboratory Abnormality Table\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = \"ALT\"\n      ),\n      worst_flag_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"WGRLOVFL\", \"WGRLOFL\", \"WGRHIVFL\", \"WGRHIFL\")),\n        selected = c(\"WGRLOVFL\")\n      ),\n      worst_flag_indicator = choices_selected(\n        value_choices(adlb, \"WGRLOVFL\"),\n        selected = \"Y\", fixed = TRUE\n      ),\n      anl_toxgrade_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"ATOXGR\")),\n        selected = c(\"ATOXGR\"),\n        fixed = TRUE\n      ),\n      base_toxgrade_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"BTOXGR\")),\n        selected = c(\"BTOXGR\"),\n        fixed = TRUE\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:26:32.4707 pid:12041 token:[] teal.modules.clinical Initializing tm_t_shift_by_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt10_bl.html",
+    "href": "tables/lab-results/lbt10_bl.html",
+    "title": "LBT10_BL",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting Sections\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadhy &lt;- synthetic_cdisc_dataset(\"latest\", \"adhy\")\n\nadhy_liver &lt;- adhy %&gt;%\n  filter(PARAMCD %in% c(\n    \"BL2AL2CB\", \"BL2AS2CB\", \"BG2AL2CB\", \"BG2AS2CB\", \"B2A2L2CB\", \"B2A2S2CB\", \"B2A5L2CB\", \"B2A5S2CB\"\n  )) %&gt;%\n  mutate(PARAMCAT = case_when(\n    PARAMCD %in% c(\"BL2AL2CB\", \"BL2AS2CB\") ~ \"Total Bilirubin &lt;= 2xULN\",\n    PARAMCD %in% c(\"BG2AL2CB\", \"BG2AS2CB\") ~ \"Total Bilirubin &gt; 2xULN\",\n    PARAMCD %in% c(\"B2A2L2CB\", \"B2A2S2CB\") ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN\",\n    PARAMCD %in% c(\"B2A5L2CB\", \"B2A5S2CB\") ~ \"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN\"\n  )) %&gt;%\n  mutate(AVALC_FORMAT = case_when(\n    PARAMCD %in% c(\"BL2AL2CB\", \"BG2AL2CB\", \"B2A2L2CB\", \"B2A5L2CB\") & AVALC == \"Y\" ~ \"ALT &gt;3xULN at 2 Visits\",\n    PARAMCD %in% c(\"BL2AS2CB\", \"BG2AS2CB\", \"B2A2S2CB\", \"B2A5S2CB\") & AVALC == \"Y\" ~ \"AST &gt;3xULN at 2 Visits\",\n    TRUE ~ \"Criteria not met\"\n  ))\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nanl &lt;- df_explicit_na(adhy_liver)\n\n\n\n\n\nCodetbl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_rows_by(\"PARAMCAT\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"AVALC_FORMAT\",\n    .stats = c(\"fraction\"),\n    denom = \"n\",\n    drop = TRUE\n  ) %&gt;%\n  build_table(anl, alt_counts_df = adsl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- tbl %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                               ARM A            ARM B            ARM C     \n                              (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                   \n  ALT &gt;3xULN at 2 Visits   25/134 (18.7%)   20/134 (14.9%)   27/132 (20.5%)\n  AST &gt;3xULN at 2 Visits   22/134 (16.4%)   14/134 (10.4%)   37/132 (28.0%)\nTotal Bilirubin &gt; 2xULN                                                    \n  ALT &gt;3xULN at 2 Visits   26/134 (19.4%)   31/134 (23.1%)   23/132 (17.4%)\n  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   27/134 (20.1%)   26/132 (19.7%)\n\n\n\n\n\nCodetbl2 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_rows_by(\"PARAMCAT\", split_fun = remove_split_levels(\"Total Bilirubin &gt; 2xULN\")) %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\n    vars = \"AVALC_FORMAT\",\n    .stats = c(\"fraction\"),\n    denom = \"n\",\n    drop = TRUE\n  ) %&gt;%\n  build_table(anl, alt_counts_df = adsl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  ifelse(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- tbl2 %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                               ARM A            ARM B            ARM C     \n                              (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————\nTotal Bilirubin &lt;= 2xULN                                                   \n  ALT &gt;3xULN at 2 Visits   25/134 (18.7%)   20/134 (14.9%)   27/132 (20.5%)\n  AST &gt;3xULN at 2 Visits   22/134 (16.4%)   14/134 (10.4%)   37/132 (28.0%)\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ADA/adat03.html",
+    "href": "tables/ADA/adat03.html",
+    "title": "ADAT03",
+    "section": "",
+    "text": "Data Setup\nStandard Table (μg/mL)\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\")\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadab &lt;- df_explicit_na(adab)\nadpc &lt;- df_explicit_na(adpc)\n\n# Adjust zzz parameter\nmax_conc &lt;- 15\n\nadpc &lt;- adpc %&gt;% select(USUBJID, NFRLT, AVAL, AVALU, AVALCAT1)\n\nanl &lt;- adab %&gt;%\n  filter(., PARAM == \"ADA interpreted per sample result\") %&gt;%\n  select(-AVAL, AVALC, AVALU)\n\nanl &lt;- merge(anl, adpc, by = c(\"USUBJID\", \"NFRLT\")) %&gt;%\n  mutate(AVAL_LT = ifelse(AVAL &lt;= max_conc, TRUE, FALSE))\n\n\n\n\n\nCode# parameters in columns\nadat03_stats &lt;- c(\"n\", \"mean\", \"sd\", \"median\", \"min\", \"max\", \"cv\", \"geom_mean\", \"count_fraction\")\nadat03_lbls &lt;- c(\n  n = \"Total Number\\nof Measurable\\n Samples\",\n  mean = \"Mean\",\n  sd = \"SD\",\n  median = \"Median\",\n  min = \"Minimum\",\n  max = \"Maximum\",\n  cv = \"CV (%)\",\n  geom_mean = \"Geometric Mean\",\n  count_fraction = paste0(\"Samples with\\nConcentration\\n≤ \", max_conc, \"μg/mL\")\n)\nadat03_fmts &lt;- c(\n  n = \"xx.\",\n  mean = sprintf_format(\"%.3e\"),\n  sd = sprintf_format(\"%.3e\"),\n  median = sprintf_format(\"%.3e\"),\n  min = sprintf_format(\"%.3e\"),\n  max = sprintf_format(\"%.3e\"),\n  cv = \"xx.x\",\n  geom_mean = sprintf_format(\"%.3e\"),\n  count_fraction = format_count_fraction\n)\n\nafun_list &lt;- lapply(\n  1:9,\n  function(i) make_afun(s_summary, .stats = adat03_stats[i], .formats = adat03_fmts[i], .labels = \"Overall\")\n)\n\n# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_rows_by(\n    var = \"ARM\",\n    label_pos = \"topleft\",\n    split_label = \"Treatment Group\",\n    split_fun = drop_split_levels,\n    section_div = \"\"\n  ) %&gt;%\n  add_rowcounts() %&gt;%\n  split_rows_by(\n    var = \"VISIT\",\n    label_pos = \"topleft\",\n    split_label = \"Visit\",\n    split_fun = drop_split_levels,\n    child_labels = \"hidden\"\n  ) %&gt;%\n  analyze_vars_in_cols(\n    vars = c(rep(\"AVAL\", 8), \"AVAL_LT\"),\n    .stats = adat03_stats,\n    .labels = adat03_lbls,\n    .formats = adat03_fmts\n  ) %&gt;%\n  analyze_colvars(\n    afun_list,\n    nested = FALSE,\n    extra_args = list(\".labels\" = \"Overall\")\n  )\n\nresult &lt;- build_table(lyt, anl, alt_counts_df = adsl)\n\nmain_title(result) &lt;- paste(\n  \"Summary of Serum Concentrations (μg/mL) at Timepoints Where ADA Samples Were Collected and Analyzed\\n\n  Protocol:\", unique(adab$PARCAT1)[1]\n)\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adab$PARAMCD)[1])\nfnotes_at_path(result, rowpath = NULL, colpath = c(\"multivars\", \"AVAL\")) &lt;- \"Refers to the total no. of measurable ADA samples that have a corresponding measurable drug concentration sample (i.e. results with\nvalid numeric values and LTRs). LTR results on post-dose samples are replaced by aaa µg/mL i.e. half of MQC value.\"\nfnotes_at_path(result, rowpath = NULL, colpath = c(\"multivars\", \"AVAL_LT\")) &lt;- \"In validation, the assay was able to detect yyy ng/mL of surrogate ADA in the presence of zzz µg/mL of [drug]. BLQ = Below Limit of\nQuantitation, LTR = Lower than Reportable, MQC = Minimum Quantifiable Concentration, ADA = Anti-Drug Antibodies (is also referred to as ATA,\nor Anti-Therapeutic Antibodies). RXXXXXXX is also known as [drug]\"\n\nresult\n\nSummary of Serum Concentrations (μg/mL) at Timepoints Where ADA Samples Were Collected and Analyzed\n\n  Protocol: A: Drug X Antibody\nAnalyte: R1800000\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Group                                                                                                                             \n  Visit                  Total Number                                                                                          Samples with \n                         of Measurable                                                                                         Concentration\n                          Samples {1}      Mean         SD        Median      Minimum     Maximum    CV (%)   Geometric Mean   ≤ 15μg/mL {2}\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nA: Drug X (N=536)                                                                                                                           \n  Day 1                       402        0.000e+00   0.000e+00   0.000e+00   0.000e+00   0.000e+00     NA           NA          402 (100%)  \n  Day 2                       134        1.618e+01   1.626e+00   1.619e+01   1.260e+01   1.986e+01    10.0      1.610e+01       39 (29.1%)  \n\nC: Combination (N=792)                                                                                                                      \n  Day 1                       528        0.000e+00   0.000e+00   0.000e+00   0.000e+00   0.000e+00     NA           NA          528 (100%)  \n  Day 2                       264        2.468e+01   8.645e+00   2.251e+01   1.264e+01   3.947e+01    35.0      2.315e+01       28 (10.6%)  \n\nOverall                      1328        6.540e+00   1.095e+01   0.000e+00   0.000e+00   3.947e+01   167.5          NA          997 (75.1%) \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n{1} - Refers to the total no. of measurable ADA samples that have a corresponding measurable drug concentration sample (i.e. results with\nvalid numeric values and LTRs). LTR results on post-dose samples are replaced by aaa µg/mL i.e. half of MQC value.\n{2} - In validation, the assay was able to detect yyy ng/mL of surrogate ADA in the presence of zzz µg/mL of [drug]. BLQ = Below Limit of\nQuantitation, LTR = Lower than Reportable, MQC = Minimum Quantifiable Concentration, ADA = Anti-Drug Antibodies (is also referred to as ATA,\nor Anti-Therapeutic Antibodies). RXXXXXXX is also known as [drug]\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] scda_0.1.6       dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       \n[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  \n[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ADA/adat01.html",
+    "href": "tables/ADA/adat01.html",
+    "title": "ADAT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\nlibrary(tibble)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\")\n\ncombodf &lt;- tribble(\n  ~valname, ~label, ~levelcombo, ~exargs,\n  \"all_X\", \"All Drug X\", c(\"A: Drug X\", \"C: Combination\"), list(),\n  \"all_pt\", \"All Patients\", c(\"A: Drug X\", \"B: Placebo\", \"C: Combination\"), list()\n)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadab &lt;- adab %&gt;%\n  filter(PARCAT1 == \"A: Drug X Antibody\") %&gt;%\n  select(-ARRLT, -NRRLT)\n\n# Baseline Pts\nadab_b &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL == \"Y\",\n    ADABLPFL == \"Y\",\n    PARAM %in% c(\"ADA interpreted per sample result\")\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU) %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate_at(\n    c(\"ADA interpreted per sample result\"),\n    as.logical\n  ) %&gt;%\n  mutate(\n    ADABLPFL = ADABLPFL == \"Y\",\n    PADABLPFL = `ADA interpreted per sample result` == \"TRUE\",\n    NADABLPFL = `ADA interpreted per sample result` == \"FALSE\"\n  ) %&gt;%\n  var_relabel(\n    ADABLPFL = \"Baseline evaluable patients\",\n    PADABLPFL = \"Patient with a positive sample at baseline\",\n    NADABLPFL = \"Patient with no positive samples at baseline\"\n  )\n\n# Post Baseline Treatment Enhanced NAb positive Pts\nadab_pb &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    ADPBLPFL == \"Y\",\n    PARAM %in% c(\n      \"ADA interpreted per sample result\",\n      \"Treatment Emergent - Positive\",\n      \"Treatment induced ADA\",\n      \"Treatment enhanced ADA\",\n      \"Treatment Emergent - Negative\",\n      \"Treatment unaffected\"\n    )\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate(\n    across(\n      any_of(c(\n        \"ADA interpreted per sample result\", \"Treatment Emergent - Positive\",\n        \"Treatment induced ADA\", \"Treatment enhanced ADA\",\n        \"Treatment Emergent - Negative\", \"Treatment unaffected\"\n      )),\n      as.logical\n    )\n  ) %&gt;%\n  mutate(\n    ADPBLPFL = ADPBLPFL == \"Y\",\n    PTEFL = if (exists(\"Treatment Emergent - Positive\", where = .)) `Treatment Emergent - Positive` == \"TRUE\" else FALSE,\n    TIFL = if (exists(\"Treatment induced ADA\", where = .)) `Treatment induced ADA` == \"TRUE\" else FALSE,\n    TEFL = if (exists(\"Treatment enhanced ADA\", where = .)) `Treatment enhanced ADA` == \"TRUE\" else FALSE,\n    NTEFL = if (exists(\"Treatment Emergent - Negative\", where = .)) `Treatment Emergent - Negative` == \"TRUE\" else FALSE,\n    TUFL = if (exists(\"Treatment unaffected\", where = .)) `Treatment unaffected` == \"TRUE\" else FALSE\n  ) %&gt;%\n  var_relabel(\n    ADPBLPFL = \"Post-baseline evaluable patients\",\n    PTEFL = \"Patient positive for Treatment Emergent ADA\",\n    TIFL = \"Treatment-induced ADA\",\n    TEFL = \"Treatment-enhanced ADA\",\n    NTEFL = \"Patient negative for Treatment Emergent ADA\",\n    TUFL = \"Treatment unaffected\"\n  )\n\n\n\n\n\nCode# Layout for Baseline Prevalence of NAbs\nlyt_bl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"ADABLPFL\",\n    .stats = \"count\",\n    var_labels = \"Baseline Prevalence of ADAs\",\n    show_labels = \"visible\",\n    table_names = \"t1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"PADABLPFL\",\n    table_names = \"t2\",\n    .indent_mods = 1L,\n    var_labels = \"a\",\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NADABLPFL\",\n    .stats = \"count\",\n    show_labels = \"hidden\",\n    .indent_mods = 1L,\n    table_names = \"t3\"\n  )\n\n# Layout for incidence of NAbs\nlyt_pb &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"ADPBLPFL\",\n    .stats = \"count\",\n    var_labels = \"Incidence of Treatment Emergent ADAs\",\n    show_labels = \"visible\",\n    table_names = \"tb1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"PTEFL\",\n    table_names = \"tb2\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"TIFL\", \"TEFL\"),\n    .stats = \"count\",\n    table_names = \"tb3\",\n    .indent_mods = 2L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NTEFL\",\n    table_names = \"tb4\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"TUFL\",\n    .stats = \"count\",\n    table_names = \"tb5\",\n    .indent_mods = 2L,\n    show_labels = \"hidden\"\n  )\n\nresult_1 &lt;- build_table(lyt_bl, df = adab_b, alt_counts_df = adsl)\nresult_2 &lt;- build_table(lyt_pb, df = adab_pb, alt_counts_df = adsl)\n\n# Combine tables.\nresult_1@col_info &lt;- result_2@col_info\nresult &lt;- rbind(result_1, result_2)\n\n# Change the column order.\nresult &lt;- cbind_rtables(result[, 1], result[, 3]) %&gt;%\n  cbind_rtables(result[, 4]) %&gt;%\n  cbind_rtables(result[, 2]) %&gt;%\n  cbind_rtables(result[, 5])\n\nmain_title(result) &lt;- paste(\n  \"Baseline Prevalence and Incidence of Treatment Emergent ADA\"\n)\nmain_footer(result) &lt;- paste(\n  \"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient = a patient with an ADA assay result from a baseline sample(s)\n  Post-baseline evaluable patient = a patient with an ADA assay result from at least one post-baseline sample Number of patients positive for Treatment Emergent\n  ADA = the number (and percentage) of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.\n  Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.\n  Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\n  Number of patients negative for Treatment Emergent ADA = number of post-baseline evaluable patients with negative or missing baseline ADA result(s) and all negative post-baseline results, or a patient who is treatment unaffected.\n  Treatment unaffected = A post-baseline evaluable patient with a positive ADA result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing.\n  For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.\"\n)\nresult\n\nBaseline Prevalence and Incidence of Treatment Emergent ADA\n\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                               A: Drug X    C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X \n                                                (N=134)        (N=132)         (N=0)      (N=134)       (N=266)  \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nBaseline Prevalence of ADAs                                                                                      \n  Baseline evaluable patients                     134            132             0           0            266    \nPatient with a positive sample at baseline     63 (47.0%)     64 (48.5%)        NA           NA       127 (47.7%)\nPatient with no positive samples at baseline       71             68             0           0            139    \nIncidence of Treatment Emergent ADAs                                                                             \n  Post-baseline evaluable patients                134            132             0           0            266    \nPatient positive for Treatment Emergent ADA        0              0             NA           NA            0     \nTreatment-induced ADA                              0              0              0           0             0     \nTreatment-enhanced ADA                             0              0              0           0             0     \nPatient negative for Treatment Emergent ADA        0              0             NA           NA            0     \nTreatment unaffected                               0              0              0           0             0     \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient = a patient with an ADA assay result from a baseline sample(s)\n  Post-baseline evaluable patient = a patient with an ADA assay result from at least one post-baseline sample Number of patients positive for Treatment Emergent\n  ADA = the number (and percentage) of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.\n  Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.\n  Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\n  Number of patients negative for Treatment Emergent ADA = number of post-baseline evaluable patients with negative or missing baseline ADA result(s) and all negative post-baseline results, or a patient who is treatment unaffected.\n  Treatment unaffected = A post-baseline evaluable patient with a positive ADA result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing.\n  For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      \n[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/deaths/dtht01.html",
+    "href": "tables/deaths/dtht01.html",
+    "title": "DTHT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting  Sections to Display\nTable for Studies Collecting Death  Information from Public Records\nTable Adding Details for “All other causes”  Category for Studies Collecting Death  Information from Public Records\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl) %&gt;% filter(SAFFL == \"Y\")\n\n# Reorder the levels in \"DTHCAT\" to put Other category at the end.\nadsl$DTHCAT &lt;- factor(adsl$DTHCAT, levels = c(\"ADVERSE EVENT\", \"PROGRESSIVE DISEASE\", \"OTHER\", \"&lt;Missing&gt;\"))\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", split_fun = add_overall_level(\"All Patients\", first = FALSE)) %&gt;%\n  count_values(\n    \"DTHFL\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Total number of deaths\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\")\n  ) %&gt;%\n  analyze_vars(vars = c(\"DTHCAT\"), var_labels = c(\"Primary Cause of Death\"))\n\nresult &lt;- build_table(lyt, df = adsl)\nresult\n\n                         A: Drug X    B: Placebo   C: Combination   All Patients\n                          (N=134)      (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————\nTotal number of deaths   25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \nPrimary Cause of Death                                                          \n  n                          25           23             22              70     \n  ADVERSE EVENT           9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) \n  PROGRESSIVE DISEASE     8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) \n  OTHER                   8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", split_fun = add_overall_level(\"All Patients\", first = FALSE)) %&gt;%\n  count_values(\n    \"DTHFL\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Total number of deaths\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\")\n  ) %&gt;%\n  analyze_vars(vars = c(\"DTHCAT\"), var_labels = c(\"Primary Cause of Death\")) %&gt;%\n  split_rows_by(\"DTHCAT\", split_fun = keep_split_levels(\"OTHER\"), child_labels = \"hidden\") %&gt;%\n  analyze_vars(\n    \"DTHCAUS\",\n    .stats = \"count_fraction\",\n    .indent_mods = c(\"count_fraction\" = 2L),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"LDDTHGR1\",\n    nested = FALSE,\n    var_labels = \"Days from last drug administration\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  split_rows_by(\n    \"LDDTHGR1\",\n    split_fun = remove_split_levels(\"&lt;Missing&gt;\"),\n    split_label = \"Primary cause by days from last study drug administration\",\n    label_pos = \"visible\"\n  ) %&gt;%\n  analyze_vars(\"DTHCAT\")\n\nresult &lt;- build_table(lyt, df = adsl) %&gt;% prune_table()\n\nresult\n\n                                                            A: Drug X    B: Placebo   C: Combination   All Patients\n                                                             (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of deaths                                      25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \nPrimary Cause of Death                                                                                             \n  n                                                             25           23             22              70     \n  ADVERSE EVENT                                              9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) \n  PROGRESSIVE DISEASE                                        8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) \n  OTHER                                                      8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) \n    LOST TO FOLLOW UP                                        2 (25%)      2 (20%)       2 (33.3%)        6 (25%)   \n    MISSING                                                  2 (25%)      3 (30%)       2 (33.3%)       7 (29.2%)  \n    Post-study reporting of death                           1 (12.5%)     2 (20%)       1 (16.7%)       4 (16.7%)  \n    SUICIDE                                                  2 (25%)      2 (20%)       1 (16.7%)       5 (20.8%)  \n    UNKNOWN                                                 1 (12.5%)     1 (10%)           0            2 (8.3%)  \nDays from last drug administration                                                                                 \n  n                                                             25           23             22              70     \n  &lt;=30                                                       14 (56%)    11 (47.8%)     14 (63.6%)      39 (55.7%) \n  &gt;30                                                        11 (44%)    12 (52.2%)     8 (36.4%)       31 (44.3%) \nPrimary cause by days from last study drug administration                                                          \n  &lt;=30                                                                                                             \n    n                                                           14           11             14              39     \n    ADVERSE EVENT                                           4 (28.6%)    2 (18.2%)      6 (42.9%)       12 (30.8%) \n    PROGRESSIVE DISEASE                                     6 (42.9%)    3 (27.3%)      4 (28.6%)       13 (33.3%) \n    OTHER                                                   4 (28.6%)    6 (54.5%)      4 (28.6%)       14 (35.9%) \n  &gt;30                                                                                                              \n    n                                                           11           12             8               31     \n    ADVERSE EVENT                                           5 (45.5%)    5 (41.7%)       4 (50%)        14 (45.2%) \n    PROGRESSIVE DISEASE                                     2 (18.2%)     3 (25%)        2 (25%)        7 (22.6%)  \n    OTHER                                                   4 (36.4%)    4 (33.3%)       2 (25%)        10 (32.3%) \n\n\n\n\n\nCodedthcaus_levels &lt;- levels(adsl[adsl$DTHCAT == \"OTHER\", ]$DTHCAUS)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", split_fun = add_overall_level(\"All Patients\", first = FALSE)) %&gt;%\n  count_values(\n    \"DTHFL\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Total number of deaths\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\")\n  ) %&gt;%\n  analyze_vars(\n    vars = c(\"DTHCAT\"),\n    var_labels = c(\"Primary Cause of Death\"),\n    table_names = \"primary_cause\"\n  ) %&gt;%\n  split_rows_by(\n    \"DTHCAT\",\n    split_fun = keep_split_levels(\"OTHER\"),\n    child_labels = \"hidden\"\n  ) %&gt;%\n  count_values(\n    \"DTHCAUS\",\n    values = dthcaus_levels[5],\n    .labels = c(count_fraction = \"Post-study reportings of death\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\"),\n    .indent_mods = c(count_fraction = 2L),\n    table_names = \"post_study_deaths\"\n  ) %&gt;%\n  count_values(\n    \"DTHCAUS\",\n    values = dthcaus_levels[-5],\n    .labels = c(count_fraction = \"All other causes\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\"),\n    .indent_mods = c(count_fraction = 2L),\n    table_names = \"all_other_causes\"\n  )\n\nresult &lt;- build_table(lyt, df = adsl)\n\nresult\n\n                                     A: Drug X    B: Placebo   C: Combination   All Patients\n                                      (N=134)      (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of deaths               25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \nPrimary Cause of Death                                                                      \n  n                                      25           23             22              70     \n  ADVERSE EVENT                       9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) \n  PROGRESSIVE DISEASE                 8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) \n  OTHER                               8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) \n    Post-study reportings of death   1 (12.5%)    2 (20.0%)      1 (16.7%)       4 (16.7%)  \n    All other causes                 7 (87.5%)    8 (80.0%)      5 (83.3%)       20 (83.3%) \n\n\n\n\n\nCodedthcaus_levels &lt;- levels(adsl[adsl$DTHCAT == \"OTHER\", ]$DTHCAUS)\n\n# create a helper variable DTHCAUS_other\nadsl &lt;- adsl %&gt;%\n  mutate(\n    DTHCAUS_other = factor(ifelse(\n      DTHCAT == \"OTHER\" & DTHCAUS != \"Post-study reporting of death\", as.character(DTHCAUS), NA\n    ), levels = c(\"LOST TO FOLLOW UP\", \"SUICIDE\", \"UNKNOWN\", \"MISSING\")) %&gt;% explicit_na()\n  )\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", split_fun = add_overall_level(\"All Patients\", first = FALSE)) %&gt;%\n  count_values(\n    \"DTHFL\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Total number of deaths\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\")\n  ) %&gt;%\n  analyze_vars(\n    vars = c(\"DTHCAT\"),\n    var_labels = c(\"Primary Cause of Death\"),\n    table_names = \"primary_cause\"\n  ) %&gt;%\n  split_rows_by(\"DTHCAT\", split_fun = keep_split_levels(\"OTHER\"), child_labels = \"hidden\") %&gt;%\n  count_values(\n    \"DTHCAUS\",\n    values = dthcaus_levels[5],\n    .labels = c(count_fraction = \"Post-study reportings of death\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\"),\n    .indent_mods = c(count_fraction = 2L),\n    table_names = \"post_study_deaths\"\n  ) %&gt;%\n  count_values(\n    \"DTHCAUS\",\n    values = dthcaus_levels[-5],\n    .labels = c(count_fraction = \"All other causes\"),\n    .formats = c(count_fraction = \"xx (xx.x%)\"),\n    .indent_mods = c(count_fraction = 2L),\n    table_names = \"all_other_causes\"\n  ) %&gt;%\n  analyze_vars(\n    \"DTHCAUS_other\",\n    .stats = \"count_fraction\",\n    .indent_mods = c(\"count_fraction\" = 3L),\n    show_labels = \"hidden\"\n  )\n\nresult &lt;- build_table(lyt, df = adsl)\n\nresult\n\n                                     A: Drug X    B: Placebo   C: Combination   All Patients\n                                      (N=134)      (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of deaths               25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \nPrimary Cause of Death                                                                      \n  n                                      25           23             22              70     \n  ADVERSE EVENT                       9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) \n  PROGRESSIVE DISEASE                 8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) \n  OTHER                               8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) \n    Post-study reportings of death   1 (12.5%)    2 (20.0%)      1 (16.7%)       4 (16.7%)  \n    All other causes                 7 (87.5%)    8 (80.0%)      5 (83.3%)       20 (83.3%) \n      LOST TO FOLLOW UP              2 (28.6%)     2 (25%)        2 (40%)         6 (30%)   \n      SUICIDE                        2 (28.6%)     2 (25%)        1 (20%)         5 (25%)   \n      UNKNOWN                        1 (14.3%)    1 (12.5%)          0            2 (10%)   \n      MISSING                        2 (28.6%)    3 (37.5%)       2 (40%)         7 (35%)   \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet04_pi.html",
+    "href": "tables/adverse-events/aet04_pi.html",
+    "title": "AET04_PI",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Patients Treated with a Particular Treatment by Highest NCI  CTCAE Grade (specifying a treatment for selecting preferred terms)\nAdverse Events Reported in \\(\\geq\\) 5% of Patients by  Highest NCI CTCAE Grade (changing the threshold)\nAdverse Events Reported in \\(\\geq\\) 5% of Patients and \\(\\geq\\) 2% Difference Between Treatments by Highest  NCI CTCAE Grade (using more than one condition)\nAdverse Events Reported in \\(\\geq\\) 10% of Patients for Any Grade  or \\(\\geq\\) 5% of Patients for Grade 3-4 by Highest NCI CTCAE  Grade (using different condition depending on the grade)\nStandard Table with  Modified Grade Grouping\nStandard Table with  Overlapping Grade Groupings\nStandard Table without SOCs\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\npreprocess_adae &lt;- function(adae) {\n  adae %&gt;%\n    dplyr::group_by(ACTARM, USUBJID, AEBODSYS, AEDECOD) %&gt;%\n    dplyr::summarize(\n      MAXAETOXGR = max(as.numeric(AETOXGR)),\n      .groups = \"drop\"\n    ) %&gt;%\n    dplyr::ungroup() %&gt;%\n    dplyr::mutate(\n      MAXAETOXGR = factor(MAXAETOXGR),\n      AEDECOD = droplevels(as.factor(AEDECOD))\n    )\n}\n\nfull_table_aet04_pi &lt;- function(adsl, adae_max) {\n  grade_groups &lt;- list(\n    \"Any Grade (%)\" = c(\"1\", \"2\", \"3\", \"4\", \"5\"),\n    \"Grade 3-4 (%)\" = c(\"3\", \"4\"),\n    \"Grade 5 (%)\" = \"5\"\n  )\n\n  col_counts &lt;- rep(table(adsl$ACTARM), each = length(grade_groups))\n  basic_table() %&gt;%\n    split_cols_by(\"ACTARM\") %&gt;%\n    split_cols_by_groups(\"MAXAETOXGR\", groups = grade_groups) %&gt;%\n    split_rows_by(\"AEBODSYS\",\n      child_labels = \"visible\", nested = FALSE, indent_mod = -1L,\n      split_fun = trim_levels_in_group(\"AEDECOD\")\n    ) %&gt;%\n    append_topleft(\"MedDRA System Organ Class\") %&gt;%\n    summarize_num_patients(\n      var = \"USUBJID\",\n      .stats = \"unique\",\n      .labels = \"Total number of patients with at least one adverse event\"\n    ) %&gt;%\n    analyze_vars(\n      \"AEDECOD\",\n      na.rm = FALSE,\n      denom = \"N_col\",\n      .stats = \"count_fraction\",\n      .formats = c(count_fraction = format_fraction_threshold(0.01))\n    ) %&gt;%\n    append_topleft(\"  MedDRA Preferred Term\") %&gt;%\n    build_table(adae_max, col_counts = col_counts)\n}\n\ncriteria_fun &lt;- function(tr) {\n  is(tr, \"ContentRow\")\n}\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae_max &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\") %&gt;%\n  preprocess_adae() %&gt;%\n  df_explicit_na()\n\n\n\n\n\nCodefull_table &lt;- full_table_aet04_pi(adsl, adae_max) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nat_least_10percent_any &lt;- has_fraction_in_any_col(atleast = 0.1, col_indices = c(1, 4, 7))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_10percent_any))\n\nresult\n\nMedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                             \ndcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     \ndcd A.1.1.1.2                    36               0              0             36               0              0             38               0              0     \ncl B.2                                                                                                                                                             \ndcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     \ndcd B.2.1.2.1                    37              37              0             33              33              0             39              39              0     \ncl D.1                                                                                                                                                             \ndcd D.1.1.1.1                    37               0             37             31               0             31             39               0             39     \ndcd D.1.1.4.2                    36              36              0             31              31              0             38              38              0     \ncl D.2                                                                                                                                                             \ndcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     \ncl B.1                                                                                                                                                             \ndcd B.1.1.1.1                    35               0             35             37               0             37             33               0             33     \ncl C.2                                                                                                                                                             \ndcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     \ncl C.1                                                                                                                                                             \ndcd C.1.1.1.3                    32              32              0             34              34              0             33              33              0     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example uses the “Any Grade” column for treatment A: Drug X with a filtering threshold at 0.37; AEs reported in greater than 37% of patients in treatment A: Drug X are shown. This can be changed by varying the parameter values in the has_fraction_in_cols function.\n\nCodefull_table &lt;- full_table_aet04_pi(adsl, adae_max) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nat_least_37percent_any_drugx &lt;- has_fraction_in_cols(atleast = 0.37, col_indices = 1)\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_37percent_any_drugx))\n\nresult\n\nMedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                             \ndcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     \ncl D.1                                                                                                                                                             \ndcd D.1.1.1.1                    37               0             37             31               0             31             39               0             39     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.40 to demonstrate the filtering ability; AEs reported in greater than 40% of patients are shown. This can be changed by varying the parameter values in the has_fraction_in_any_col function.\n\nCodefull_table &lt;- full_table_aet04_pi(adsl, adae_max) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nat_least_40percent_any &lt;- has_fraction_in_any_col(atleast = 0.40, col_indices = c(1, 4, 7))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_40percent_any))\n\nresult\n\nMedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                             \ndcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     \ncl B.2                                                                                                                                                             \ndcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     \ncl D.2                                                                                                                                                             \ndcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     \ncl C.2                                                                                                                                                             \ndcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 to filter for AEs reported in \\(\\geq\\) 30% of patients and AEs reported with a \\(\\geq\\) 15% difference between treatments to demonstrate the filtering ability; this can be changed by varying the parameter values in the has_fraction_in_any_col and has_fractions_difference functions.\n\nCodefull_table &lt;- full_table_aet04_pi(adsl, adae_max) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nat_least_30percent_any &lt;- has_fraction_in_any_col(atleast = 0.3, col_indices = c(1, 4, 7))\n\nat_least_15percent_diff &lt;- has_fractions_difference(atleast = 0.15, col_indices = c(1, 4, 7))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_30percent_any & at_least_15percent_diff))\n\nresult\n\nMedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl C.2                                                                                                                                                             \ndcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example filters using column indices 1, 4, and 7 to include AEs reported in \\(\\geq\\) 40% of patients and using column indices 2, 5, and 8 to include grade 3-4 AEs reported in \\(\\geq\\) 20% of patients. These thresholds are chosen to demonstrate the filtering ability; they can be changed by varying parameter values in the has_fraction_in_any_col function.\n\nCodefull_table &lt;- full_table_aet04_pi(adsl, adae_max) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nat_least_40percent_any &lt;- has_fraction_in_any_col(atleast = 0.4, col_indices = c(1, 4, 7))\n\nat_least_20percent_g34 &lt;- has_fraction_in_any_col(atleast = 0.20, col_indices = c(2, 5, 8))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_40percent_any | at_least_20percent_g34))\n\nresult\n\nMedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                             \ndcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     \ncl B.2                                                                                                                                                             \ndcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     \ndcd B.2.1.2.1                    37              37              0             33              33              0             39              39              0     \ncl D.1                                                                                                                                                             \ndcd D.1.1.4.2                    36              36              0             31              31              0             38              38              0     \ncl D.2                                                                                                                                                             \ndcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     \ncl C.2                                                                                                                                                             \ndcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     \ncl C.1                                                                                                                                                             \ndcd C.1.1.1.3                    32              32              0             34              34              0             33              33              0     \n\n\n\n\nNote: User can specify/modify the grouping of grades, as shown in this example. In addition, the user needs to specify the column index for filtering the table. The current example uses the “Any Grade” columns with a filtering threshold at 0.40; this can be changed by varying the parameter values in the has_fraction_in_any_col function.\n\nCodegrade_groups &lt;- list(\n  \"Any Grade (%)\" = c(\"1\", \"2\", \"3\", \"4\", \"5\"),\n  \"Grade 1-2 (%)\" = c(\"1\", \"2\"),\n  \"Grade 3-4 (%)\" = c(\"3\", \"4\"),\n  \"Grade 5 (%)\" = \"5\"\n)\n\ncol_counts &lt;- rep(table(adsl$ACTARM), each = length(grade_groups))\n\nfull_table &lt;- basic_table() %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_cols_by_groups(\"MAXAETOXGR\", groups = grade_groups) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    child_labels = \"visible\", nested = FALSE, indent_mod = -1L,\n    split_fun = trim_levels_in_group(\"AEDECOD\")\n  ) %&gt;%\n  append_topleft(\"MedDRA System Organ Class\") %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  analyze_vars(\n    \"AEDECOD\",\n    na.rm = FALSE,\n    denom = \"N_col\",\n    .stats = \"count_fraction\",\n    .formats = c(count_fraction = format_fraction_threshold(0.01))\n  ) %&gt;%\n  append_topleft(\"  MedDRA Preferred Term\") %&gt;%\n  build_table(adae_max, col_counts = col_counts) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 5, 9)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 5, 9)),\n    decreasing = TRUE\n  )\n\nat_least_40percent_any &lt;- has_fraction_in_any_col(atleast = 0.4, col_indices = c(1, 5, 9))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_40percent_any))\n\nresult\n\nMedDRA System Organ Class                            A: Drug X                                                    B: Placebo                                                  C: Combination                       \n  MedDRA Preferred Term     Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)\n                               (N=134)         (N=134)         (N=134)        (N=134)        (N=134)         (N=134)         (N=134)        (N=134)        (N=132)         (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                                                                             \ndcd A.1.1.1.1                    37              37               0              0             34              34               0              0             48              48               0              0     \ncl B.2                                                                                                                                                                                                             \ndcd B.2.2.3.1                    36              36               0              0             40              40               0              0             39              39               0              0     \ncl D.2                                                                                                                                                                                                             \ndcd D.2.1.5.3                    35              35               0              0             43              43               0              0             43              43               0              0     \ncl C.2                                                                                                                                                                                                             \ndcd C.2.1.2.1                    26              26               0              0             36              36               0              0             42              42               0              0     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example uses column indices 1, 5, and 9 with a filtering threshold at 0.40 to demonstrate the filtering ability; any grade AEs reported in greater than 40% of patients are shown. This can be changed by varying the parameter values in the has_fraction_in_any_col function.\n\nCodegrade_groups &lt;- list(\n  \"Any Grade (%)\" = c(\"1\", \"2\", \"3\", \"4\", \"5\"),\n  \"Grade 3-4 (%)\" = c(\"3\", \"4\"),\n  \"Grade 3-5 (%)\" = c(\"3\", \"4\", \"5\"),\n  \"Grade 5 (%)\" = \"5\"\n)\n\ncol_counts &lt;- rep(table(adsl$ACTARM), each = length(grade_groups))\nfull_table &lt;- basic_table() %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_cols_by_groups(\"MAXAETOXGR\", groups = grade_groups) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    child_labels = \"visible\", nested = FALSE, indent_mod = -1L,\n    split_fun = trim_levels_in_group(\"AEDECOD\")\n  ) %&gt;%\n  append_topleft(\"MedDRA System Organ Class\") %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  analyze_vars(\n    \"AEDECOD\",\n    na.rm = FALSE,\n    denom = \"N_col\",\n    .stats = \"count_fraction\",\n    .formats = c(count_fraction = format_fraction_threshold(0.01))\n  ) %&gt;%\n  append_topleft(\"  MedDRA Preferred Term\") %&gt;%\n  build_table(adae_max, col_counts = col_counts) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = score_occurrences_cont_cols(col_indices = c(1, 5, 9)),\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 5, 9)),\n    decreasing = TRUE\n  )\n\nat_least_40percent_any &lt;- has_fraction_in_any_col(atleast = 0.4, col_indices = c(1, 5, 9))\n\nresult &lt;- full_table %&gt;%\n  trim_rows(criteria = criteria_fun) %&gt;%\n  prune_table(keep_rows(at_least_40percent_any))\n\nresult\n\nMedDRA System Organ Class                            A: Drug X                                                    B: Placebo                                                  C: Combination                       \n  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)\n                               (N=134)         (N=134)         (N=134)        (N=134)        (N=134)         (N=134)         (N=134)        (N=134)        (N=132)         (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ncl A.1                                                                                                                                                                                                             \ndcd A.1.1.1.1                    37               0               0              0             34               0               0              0             48               0               0              0     \ncl B.2                                                                                                                                                                                                             \ndcd B.2.2.3.1                    36               0               0              0             40               0               0              0             39               0               0              0     \ncl D.2                                                                                                                                                                                                             \ndcd D.2.1.5.3                    35               0               0              0             43               0               0              0             43               0               0              0     \ncl C.2                                                                                                                                                                                                             \ndcd C.2.1.2.1                    26               0               0              0             36               0               0              0             42               0               0              0     \n\n\n\n\nNote: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.20 to demonstrate the filtering ability; any grade AEs (Preferred Terms Only) reported in greater than 20% of patients are shown. This can be changed by varying the parameter values in the has_fraction_in_any_col function.\n\nCodegrade_groups &lt;- list(\n  \"Any Grade (%)\" = c(\"1\", \"2\", \"3\", \"4\", \"5\"),\n  \"Grade 3-4 (%)\" = c(\"3\", \"4\"),\n  \"Grade 5 (%)\" = \"5\"\n)\n\ncol_counts &lt;- rep(table(adsl$ACTARM), each = length(grade_groups))\n\nfull_table &lt;- basic_table() %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_cols_by_groups(\"MAXAETOXGR\", groups = grade_groups) %&gt;%\n  analyze_vars(\n    \"AEDECOD\",\n    na.rm = FALSE,\n    denom = \"N_col\",\n    .stats = \"count_fraction\",\n    .formats = c(count_fraction = format_fraction_threshold(0.01))\n  ) %&gt;%\n  append_topleft(\"MedDRA Preferred Term\") %&gt;%\n  build_table(adae_max, col_counts = col_counts)\n\nat_least_20percent_any &lt;- has_fraction_in_any_col(atleast = 0.2, col_indices = c(1, 4, 7))\n\nresult &lt;- full_table %&gt;%\n  prune_table(keep_rows(at_least_20percent_any)) %&gt;%\n  sort_at_path(\n    path = c(\"AEDECOD\"),\n    scorefun = score_occurrences_cols(col_indices = c(1, 4, 7)),\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA Preferred Term                    A: Drug X                                    B: Placebo                                  C: Combination               \n                        Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)\n                           (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\ndcd D.2.1.5.3                35               0              0             43               0              0             43               0              0     \ndcd A.1.1.1.1                37               0              0             34               0              0             48               0              0     \ndcd B.2.2.3.1                36               0              0             40               0              0             39               0              0     \ndcd A.1.1.1.2                36               0              0             36               0              0             38               0              0     \ndcd B.2.1.2.1                37              37              0             33              33              0             39              39              0     \ndcd D.1.1.1.1                37               0             37             31               0             31             39               0             39     \ndcd D.1.1.4.2                36              36              0             31              31              0             38              38              0     \ndcd B.1.1.1.1                35               0             35             37               0             37             33               0             33     \ndcd C.2.1.2.1                26               0              0             36               0              0             42               0              0     \ndcd C.1.1.1.3                32              32              0             34              34              0             33              33              0     \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADAE\", adae),\n    code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_by_grade(\n      label = \"Adverse Events by Grade Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      col_by_grade = TRUE,\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = \"AEBODSYS\"\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adae, c(\"AETOXGR\", \"AESEV\")),\n        selected = \"AETOXGR\"\n      ),\n      # List of column groups for grades used when `col_by_grade` = TRUE.\n      grading_groups = list(\n        `Any Grade (%)` = c(\"1\", \"2\", \"3\", \"4\", \"5\"),\n        `Grade 3-4 (%)` = c(\"3\", \"4\"),\n        `Grade 5 (%)` = \"5\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:23:03.0411 pid:11390 token:[] teal.modules.clinical Initializing tm_t_events_by_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet02.html",
+    "href": "tables/adverse-events/aet02.html",
+    "title": "AET02",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with  Event Totals\nTable with  High-Level Term\nTable with Preferred  Terms Only\nTable with Fill-In of  Treatment Groups\nTable of AEs with an Incidence Rate \\(\\geq\\) 5% in Any Treatment Group (subsetting  preferred terms based on frequency)\nTable of AEs with an Incidence Rate \\(\\geq\\) 5% in  Any Treatment Group (subsetting preferred terms  based on frequency with high-level terms)\nTable of AEs with an Incidence Rate \\(\\geq\\) 10%  in Any Treatment Group (subsetting  preferred terms based on frequency)\nTable of AEs with an Incidence Rate \\(\\geq\\) 3  Patients in Any Treatment Group (subsetting  preferred terms based on number of patients)\nTable of AEs with a Difference in Incidence Rate \\(\\geq\\) 5%  Between Any Treatment (subsetting preferred terms based  on difference in percentage between treatment groups)\nTable of AEs with an Incidence Rate \\(\\geq\\) 5%  in B: Placebo (subsetting preferred terms based  on frequency for a particular treatment group)\nTable of AEs with a Difference in Incidence Rate \\(\\geq\\) 5% Between  Arm A and Arm B or Arm C (displaying preferred terms with a  difference of at least x% between selected treatment groups)\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae) %&gt;%\n  var_relabel(\n    AEBODSYS = \"MedDRA System Organ Class\",\n    AEDECOD = \"MedDRA Preferred Term\"\n  ) %&gt;%\n  filter(ANL01FL == \"Y\")\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = -1L\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl)\n\n\nThe variable result corresponds to the adverse events table. However, it includes many empty rows accounting for events which were not reported. The table can be post-processed to prune empty rows and to sort rows, for example by occurrence.\n\nCoderesult &lt;- result %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination   All Patients\n  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)         (N=400)   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)    103 (78.0%)     301 (75.2%) \nOverall total number of events                                   502          480            604             1586    \ncl A.1                                                                                                               \n  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)     202 (50.5%) \n  Total number of events                                         115           99            137             351     \n  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)     128 (32.0%) \n  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)     122 (30.5%) \ncl B.2                                                                                                               \n  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)     74 (56.1%)     192 (48.0%) \n  Total number of events                                         102          106            127             335     \n  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)     123 (30.8%) \n  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)     119 (29.8%) \ncl D.1                                                                                                               \n  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)     68 (51.5%)     186 (46.5%) \n  Total number of events                                         106           84            114             304     \n  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)     120 (30.0%) \n  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)     112 (28.0%) \ncl D.2                                                                                                               \n  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) \n  Total number of events                                         49            57             65             171     \n  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) \ncl C.2                                                                                                               \n  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) \n  Total number of events                                         39            40             57             136     \n  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) \ncl B.1                                                                                                               \n  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) \n  Total number of events                                         44            43             50             137     \n  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) \ncl C.1                                                                                                               \n  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) \n  Total number of events                                         47            51             54             152     \n  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L) %&gt;%\n  count_values(\n    \"STUDYID\",\n    values = as.character(unique(adae$STUDYID)),\n    .stats = \"count\",\n    .labels = c(count = \"Total number of events\"),\n    .indent_mods = c(count = -1L)\n  )\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;% # col_count = c(table(adsl$ACTARM), sum(table(adsl$ACTARM)))\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  )\n\nresult\n\nMedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination   All Patients\n  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)         (N=400)   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)    103 (78.0%)     301 (75.2%) \nOverall total number of events                                   502          480            604             1586    \ncl A.1                                                                                                               \n  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)     202 (50.5%) \n  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)     128 (32.0%) \n  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)     122 (30.5%) \n  Total number of events                                         115           99            137             351     \ncl B.2                                                                                                               \n  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)     74 (56.1%)     192 (48.0%) \n  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)     123 (30.8%) \n  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)     119 (29.8%) \n  Total number of events                                         102          106            127             335     \ncl D.1                                                                                                               \n  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)     68 (51.5%)     186 (46.5%) \n  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)     120 (30.0%) \n  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)     112 (28.0%) \n  Total number of events                                         106           84            114             304     \ncl D.2                                                                                                               \n  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) \n  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) \n  Total number of events                                         49            57             65             171     \ncl C.2                                                                                                               \n  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) \n  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) \n  Total number of events                                         39            40             57             136     \ncl B.1                                                                                                               \n  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) \n  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) \n  Total number of events                                         44            43             50             137     \ncl C.1                                                                                                               \n  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) \n  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) \n  Total number of events                                         47            51             54             152     \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEHLT\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    indent_mod = -1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEHLT)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = c(count_fraction = -1L)) %&gt;%\n  append_varlabels(adae, c(\"AEDECOD\"), indent = 2L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedDRA System Organ Class                                                                               \n  High Level Term                                               A: Drug X    B: Placebo   C: Combination\n    MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event       100 (74.6%)   98 (73.1%)    103 (78.0%)  \nOverall total number of events                                     502          480            604      \ncl A.1                                                                                                  \n  Total number of patients with at least one adverse event     68 (50.7%)    58 (43.3%)     76 (57.6%)  \n  Total number of events                                           115           99            137      \n  hlt A.1.1.1                                                                                           \n    Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n    Total number of events                                         115           99            137      \n    dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)  \n    dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                                                  \n  Total number of patients with at least one adverse event     62 (46.3%)    56 (41.8%)     74 (56.1%)  \n  Total number of events                                           102          106            127      \n  hlt B.2.2.3                                                                                           \n    Total number of patients with at least one adverse event   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n    Total number of events                                         50            55             68      \n    dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  hlt B.2.1.2                                                                                           \n    Total number of patients with at least one adverse event   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n    Total number of events                                         52            51             59      \n    dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                                                  \n  Total number of patients with at least one adverse event     64 (47.8%)    54 (40.3%)     68 (51.5%)  \n  Total number of events                                           106           84            114      \n  hlt D.1.1.1                                                                                           \n    Total number of patients with at least one adverse event   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n    Total number of events                                         52            40             64      \n    dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  hlt D.1.1.4                                                                                           \n    Total number of patients with at least one adverse event   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n    Total number of events                                         54            44             50      \n    dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                                                  \n  Total number of patients with at least one adverse event     37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  Total number of events                                           49            57             65      \n  hlt D.2.1.5                                                                                           \n    Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n    Total number of events                                         49            57             65      \n    dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                                                  \n  Total number of patients with at least one adverse event     28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  Total number of events                                           39            40             57      \n  hlt C.2.1.2                                                                                           \n    Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n    Total number of events                                         39            40             57      \n    dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                                                  \n  Total number of patients with at least one adverse event     38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  Total number of events                                           44            43             50      \n  hlt B.1.1.1                                                                                           \n    Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n    Total number of events                                         44            43             50      \n    dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                                                  \n  Total number of patients with at least one adverse event     36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  Total number of events                                           47            51             54      \n  hlt C.1.1.1                                                                                           \n    Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n    Total number of events                                         47            51             54      \n    dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    ),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\") %&gt;%\n  append_varlabels(adae, \"AEDECOD\")\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  sort_at_path(\n    path = c(\"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedDRA Preferred Term                                       A: Drug X    B: Placebo   C: Combination\n                                                             (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event   100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of events                                         502          480            604      \ndcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)  \ndcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)  \ndcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)  \ndcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)  \ndcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)  \ndcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)  \ndcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)  \ndcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)  \ndcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)  \ndcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodeadae_5 &lt;- adae %&gt;% dplyr::filter(ACTARM != \"C: Combination\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = c(count_fraction = -1L)) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae_5, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)         0       \nOverall total number of events                                   502          480             0       \ncl A.1                                                                                                \n  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)         0       \n  Total number of events                                         115           99             0       \n  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)         0       \n  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)         0       \ncl B.2                                                                                                \n  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)         0       \n  Total number of events                                         102          106             0       \n  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)         0       \n  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)         0       \ncl D.1                                                                                                \n  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)         0       \n  Total number of events                                         106           84             0       \n  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)         0       \n  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)         0       \ncl D.2                                                                                                \n  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)         0       \n  Total number of events                                         49            57             0       \n  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)         0       \ncl B.1                                                                                                \n  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)         0       \n  Total number of events                                         44            43             0       \n  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)         0       \ncl C.1                                                                                                \n  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)         0       \n  Total number of events                                         47            51             0       \n  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)         0       \ncl C.2                                                                                                \n  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)         0       \n  Total number of events                                         39            40             0       \n  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)         0       \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_fraction_in_any_col(\n  atleast = 0.05,\n  col_names = names(table(adsl$ACTARM))\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \ncl B.1                                                              \n  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  \ncl C.1                                                              \n  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEHLT\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEHLT)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\") %&gt;%\n  append_varlabels(adae, c(\"AEDECOD\"), indent = 2L)\n\nresult &lt;- build_table(lyt, adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\"),\n    scorefun = cont_n_allcols,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences,\n    decreasing = TRUE\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_fraction_in_any_col(\n  atleast = 0.05,\n  col_names = names(table(adsl$ACTARM))\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class                                           \n  High Level Term           A: Drug X    B: Placebo   C: Combination\n    MedDRA Preferred Term    (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  hlt A.1.1.1                                                       \n    dcd A.1.1.1.1           45 (33.6%)   31 (23.1%)     52 (39.4%)  \n    dcd A.1.1.1.2           41 (30.6%)   39 (29.1%)     42 (31.8%)  \ncl B.2                                                              \n  hlt B.2.2.3                                                       \n    dcd B.2.2.3.1           38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  hlt B.2.1.2                                                       \n    dcd B.2.1.2.1           39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  hlt D.1.1.1                                                       \n    dcd D.1.1.1.1           42 (31.3%)   32 (23.9%)     46 (34.8%)  \n  hlt D.1.1.4                                                       \n    dcd D.1.1.4.2           38 (28.4%)   34 (25.4%)     40 (30.3%)  \ncl D.2                                                              \n  hlt D.2.1.5                                                       \n    dcd D.2.1.5.3           37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  hlt C.2.1.2                                                       \n    dcd C.2.1.2.1           28 (20.9%)   36 (26.9%)     48 (36.4%)  \ncl B.1                                                              \n  hlt B.1.1.1                                                       \n    dcd B.1.1.1.1           38 (28.4%)   37 (27.6%)     36 (27.3%)  \ncl C.1                                                              \n  hlt C.1.1.1                                                       \n    dcd C.1.1.1.3           36 (26.9%)   34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_fraction_in_any_col(\n  atleast = 0.10,\n  col_names = names(table(adsl$ACTARM))\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \ncl B.1                                                              \n  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  \ncl C.1                                                              \n  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    split_label = obj_label(adae$AEBODSYS),\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_count_in_any_col(\n  atleast = 3,\n  col_names = names(table(adsl$ACTARM))\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \ncl B.1                                                              \n  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  \ncl C.1                                                              \n  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_fractions_difference(\n  atleast = 0.05,\n  col_names = levels(adsl$ACTARM)\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition &lt;- has_fraction_in_cols(\n  atleast = 0.05,\n  col_names = c(\"B: Placebo\")\n)\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \ncl B.1                                                              \n  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  \ncl C.1                                                              \n  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"Total number of patients with at least one adverse event\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = 1L)\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, df = adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\ncriteria_fun &lt;- function(tr) is(tr, \"ContentRow\")\nresult &lt;- trim_rows(result, criteria = criteria_fun)\n\nrow_condition1 &lt;- has_fractions_difference(atleast = 0.05, col_names = c(\"A: Drug X\", \"B: Placebo\"))\nrow_condition2 &lt;- has_fractions_difference(atleast = 0.05, col_names = c(\"A: Drug X\", \"C: Combination\"))\nrow_condition &lt;- row_condition1 | row_condition2\nresult &lt;- prune_table(result, keep_rows(row_condition))\n\nresult\n\nMedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination\n  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————\ncl A.1                                                              \n  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  \ncl B.2                                                              \n  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  \ncl D.1                                                              \n  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  \ncl D.2                                                              \n  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  \ncl C.2                                                              \n  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADAE\", adae, code = 'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adae\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Adverse Event Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = \"AEBODSYS\"\n      ),\n      add_total = TRUE,\n      event_type = \"adverse event\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:21:44.2056 pid:11194 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet06_smq.html",
+    "href": "tables/adverse-events/aet06_smq.html",
+    "title": "AET06_SMQ",
+    "section": "",
+    "text": "Data Setup\nAdverse Events by Sex,  by SMQ and Preferred Term\nAdverse Events by Sex, by SMQ and  Preferred Term (with Customized Queries)\nAdverse Events by Other Baseline  Characteristics (e.g. Age Group)\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(stringr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadsl_labels &lt;- var_labels(adsl)\nadae_labels &lt;- var_labels(adae)\n\nadsl &lt;- adsl %&gt;%\n  mutate(\n    AGE65 = case_when(\n      AGE &gt;= 65 ~ \"&gt;= 65\",\n      TRUE ~ \"&lt; 65\"\n    ),\n    AGE65 = factor(\n      AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n    )\n  )\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AGE65 = case_when(\n      AGE &gt;= 65 ~ \"&gt;= 65\",\n      TRUE ~ \"&lt; 65\"\n    ),\n    AGE65 = factor(\n      AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n    )\n  )\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing\n# levels. For details, refer to Teal and Study Data article.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\n# Simulate a random AAG dataset.\naag &lt;- data.frame(\n  NAMVAR = c(\"SMQ01NAM\", \"SMQ01NAM\", \"SMQ02NAM\", \"CQ01NAM\", \"CQ01NAM\"),\n  SRCVAR = rep(\"AEDECOD\", 5),\n  GRPTYPE = c(\"SMQ\", \"SMQ\", \"SMQ\", \"CUSTOM\", \"CUSTOM\"),\n  REFID = c(1, 1, 2, 3, 3),\n  REFNAME = c(rep(\"C.1.1.1.3/B.2.2.3.1 AESI\", 2), \"non observed SMQ02NAM level\", rep(\"D.2.1.5.3/A.1.1.1.1 AESI\", 2)),\n  SCOPE = c(\"BROAD\", \"BROAD\", \"BROAD\", \"\", \"\"),\n  REFTERM = c(\"C.1.1.1.3\", \"B.2.2.3.1\", \"Z.9.9.9.9\", \"D.2.1.5.3\", \"A.1.1.1.1\"),\n  stringsAsFactors = FALSE\n)\n\n# Create summary AAG dataset (used for labelling).\n# Note it's important to incorporate SCOPE into the basket names for SMQs so as to\n# match the flags present in ADAE.\naag_summary &lt;- aag %&gt;%\n  select(NAMVAR, REFNAME, SCOPE) %&gt;%\n  unique() %&gt;%\n  mutate(\n    REFNAME_SCOPE = ifelse(SCOPE == \"\", REFNAME, paste0(REFNAME, \"(\", SCOPE, \")\"))\n  ) %&gt;%\n  rename(basket = NAMVAR, basket_name = REFNAME_SCOPE) %&gt;%\n  select(basket, basket_name)\n\n# Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function\nadae_smq_all &lt;- h_stack_by_baskets(\n  df = adae,\n  aag_summary = aag_summary,\n  keys = c(\"STUDYID\", \"USUBJID\", \"ACTARMCD\", \"AEDECOD\", \"SEX\", \"AGE65\")\n)\n# Post-process adae_smq_all to keep only certain baskets of interest for variant 1\n# Not need to drop baskets for variant 2 as all baskets will be considered.\nbaskets_to_drop_variant &lt;- aag_summary$basket_name[!aag_summary$basket %in% c(\"SMQ01NAM\")]\n\n# Adjust the analysis dataset based on basket subset for variant 1.\nadae_smq_1 &lt;- adae_smq_all %&gt;%\n  filter(!adae_smq_all$SMQ %in% baskets_to_drop_variant) %&gt;%\n  mutate(\n    SMQ = tern::fct_discard(SMQ, discard = baskets_to_drop_variant)\n  )\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) !is(tr, \"ContentRow\") && all_zero_or_na(tr)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_cols_by(\"SEX\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(unique = \"Total number of patients with at least one adverse event\")\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", drop = FALSE) %&gt;%\n  append_varlabels(adae_smq_1, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae_smq_1,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = cont_n_allcols) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                             ARM A                     ARM B                     ARM C         \n  Dictionary-Derived Term                                        F            M            F            M            F            M     \n                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)\nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                                         \n  Total number of patients with at least one adverse event   47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)\n  Total number of events                                         79           40           95           44           81           60    \n    dcd B.2.2.3.1                                            30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)\n    dcd C.1.1.1.3                                            30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) {\n  !is(tr, \"ContentRow\") && all_zero_or_na(tr) && !grepl(\"Total number of\", obj_label(tr))\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_cols_by(\"SEX\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(unique = \"Total number of patients with at least one adverse event\")\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    ),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", drop = FALSE) %&gt;%\n  append_varlabels(adae_smq_all, \"AEDECOD\", indent = 1L)\n\nscore_ae_pts &lt;- function(tt) {\n  count_vals &lt;- cell_values(tree_children(tt)[[\"USUBJID\"]])[[1]]\n  sum(matrix(unlist(count_vals), nrow = length(count_vals), byrow = TRUE)[, 1])\n}\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae_smq_all,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = score_ae_pts) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                             ARM A                     ARM B                     ARM C         \n  Dictionary-Derived Term                                        F            M            F            M            F            M     \n                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     59 (74.7%)   36 (65.5%)   68 (82.9%)   35 (67.3%)   61 (87.1%)   47 (75.8%)\nD.2.1.5.3/A.1.1.1.1 AESI                                                                                                                \n  Total number of patients with at least one adverse event   45 (57.0%)   29 (52.7%)   54 (65.9%)   26 (50.0%)   50 (71.4%)   37 (59.7%)\n  Total number of events                                         78           48           91           43           88           74    \n  dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\n  dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)\nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                                         \n  Total number of patients with at least one adverse event   47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)\n  Total number of events                                         79           40           95           44           81           60    \n  dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)\n  dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\nnon observed SMQ02NAM level(BROAD)                                                                                                      \n  Total number of patients with at least one adverse event       0            0            0            0            0            0     \n  Total number of events                                         0            0            0            0            0            0     \n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) !is(tr, \"ContentRow\") && all_zero_or_na(tr)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  split_cols_by(\"AGE65\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(unique = \"Total number of patients with at least one adverse event\")\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", drop = FALSE) %&gt;%\n  append_varlabels(adae_smq_1, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae_smq_1,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = cont_n_allcols) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                          ARM A                ARM B                ARM C       \n  Dictionary-Derived Term                                       &lt; 65      &gt;= 65      &lt; 65      &gt;= 65      &lt; 65      &gt;= 65\n                                                              (N=134)     (N=0)    (N=134)     (N=0)    (N=131)     (N=1)\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     72 (53.7%)     0     79 (59.0%)     0     75 (57.3%)     0  \nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                          \n  Total number of patients with at least one adverse event   72 (53.7%)     0     79 (59.0%)     0     75 (57.3%)     0  \n  Total number of events                                        119         0        139         0        141         0  \n    dcd B.2.2.3.1                                            48 (35.8%)     0     54 (40.3%)     0     51 (38.9%)     0  \n    dcd C.1.1.1.3                                            43 (32.1%)     0     46 (34.3%)     0     43 (32.8%)     0  \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n  mutate(\n    AGE65 = case_when(\n      AGE &gt;= 65 ~ \"&gt;= 65\",\n      TRUE ~ \"&lt; 65\"\n    ),\n    AGE65 = factor(\n      AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n    )\n  )\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\") %&gt;%\n  mutate(\n    AGE65 = case_when(\n      AGE &gt;= 65 ~ \"&gt;= 65\",\n      TRUE ~ \"&lt; 65\"\n    ),\n    AGE65 = factor(\n      AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n    )\n  )\n\nnames_baskets &lt;- grep(\"^(SMQ|CQ).*NAM$\", names(adae), value = TRUE)\nnames_scopes &lt;- grep(\"^SMQ.*SC$\", names(adae), value = TRUE)\n\ncs_baskets &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_baskets),\n  selected = names_baskets\n)\ncs_scopes &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_scopes),\n  selected = names_scopes,\n  fixed = TRUE\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n    mutate(\n      AGE65 = case_when(\n        AGE &gt;= 65 ~ \"&gt;= 65\",\n        TRUE ~ \"&lt; 65\"\n      ),\n      AGE65 = factor(\n        AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n        )\n    )'\n    ),\n    cdisc_dataset(\"ADAE\", adae,\n      code = 'ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\") %&gt;%\n    mutate(\n      AGE65 = case_when(\n        AGE &gt;= 65 ~ \"&gt;= 65\",\n        TRUE ~ \"&lt; 65\"\n      ),\n      AGE65 = factor(\n        AGE65,\n      levels = c(\"&lt; 65\", \"&gt;= 65\")\n        )\n    )'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_smq(\n      label = \"Adverse events by `SMQ` Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"SEX\", \"AGE65\")),\n        selected = c(\"ARM\", \"SEX\")\n      ),\n      add_total = FALSE,\n      baskets = cs_baskets,\n      scopes = cs_scopes,\n      llt = choices_selected(\n        choices = variable_choices(adae, subset = c(\"AEDECOD\")),\n        selected = \"AEDECOD\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:19:56.5276 pid:10998 token:[] teal.modules.clinical Initializing tm_t_smq\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] stringr_1.5.0                scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          \n[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         \n[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      \n[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           \n[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[85] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet05.html",
+    "href": "tables/adverse-events/aet05.html",
+    "title": "AET05",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Setting Type of Confidence Interval\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadaette &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadaette &lt;- df_explicit_na(adaette)\n\nanl &lt;- adaette %&gt;%\n  dplyr::filter(PARAM == \"Time to first occurrence of any adverse event\") %&gt;%\n  dplyr::mutate(is_event = CNSR == 0) %&gt;%\n  dplyr::mutate(n_events = as.integer(is_event))\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  estimate_incidence_rate(\n    vars = \"AVAL\",\n    n_events = \"n_events\",\n    control = control_incidence_rate(num_pt_year = 100)\n  )\n\nresult &lt;- build_table(lyt, anl, alt_counts_df = adsl)\n\nresult\n\n                                      A: Drug X        B: Placebo      C: Combination\n                                       (N=134)           (N=134)          (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\nTotal patient-years at risk             162.4             103.9            172.6     \nNumber of adverse events observed         78               104               67      \nAE rate per 100 patient-years           48.03            100.14            38.82     \n95% CI                              (37.37, 58.69)   (80.89, 119.38)   (29.53, 48.12)\n\n\n\n\nThe type of confidence interval can be specified through the conf_type argument.\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  estimate_incidence_rate(\n    vars = \"AVAL\",\n    n_events = \"n_events\",\n    control = control_incidence_rate(\n      conf_level = 0.95,\n      conf_type = \"exact\",\n      num_pt_year = 100\n    )\n  )\n\nresult &lt;- build_table(lyt, anl, alt_counts_df = adsl)\n\nresult\n\n                                      A: Drug X        B: Placebo      C: Combination\n                                       (N=134)           (N=134)          (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\nTotal patient-years at risk             162.4             103.9            172.6     \nNumber of adverse events observed         78               104               67      \nAE rate per 100 patient-years           48.03            100.14            38.82     \n95% CI                              (37.97, 59.94)   (81.82, 121.34)   (30.09, 49.30)\n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadaette &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadaette &lt;- df_explicit_na(adaette)\n\nadaette &lt;- adaette %&gt;%\n  dplyr::filter(PARAMCD %in% c(\"AETTE1\", \"AETTE2\", \"AETTE3\")) %&gt;%\n  dplyr::mutate(is_event = CNSR == 0) %&gt;%\n  dplyr::mutate(n_events = as.integer(is_event))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADAETTE\", adaette),\n    code =\n      'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))\n       ADAETTE &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adaette\"))\n       ADAETTE &lt;- ADAETTE %&gt;%\n  dplyr::filter(PARAMCD %in% c(\"AETTE1\", \"AETTE2\", \"AETTE3\")) %&gt;%\n  dplyr::mutate(is_event = CNSR == 0) %&gt;%\n  dplyr::mutate(n_events = as.integer(is_event))',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_patyear(\n      label = \"AE rate adjusted for patient-years at risk Table\",\n      dataname = \"ADAETTE\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARMCD\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adaette, \"PARAMCD\", \"PARAM\"),\n        selected = \"AETTE1\"\n      ),\n      events_var = choices_selected(\n        choices = variable_choices(adaette, \"n_events\"),\n        selected = \"n_events\",\n        fixed = TRUE\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:18:50.7364 pid:10802 token:[] teal.modules.clinical Initializing tm_t_events_patyear\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] scda_0.1.6                   dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet05_all.html",
+    "href": "tables/adverse-events/aet05_all.html",
+    "title": "AET05_ALL",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Setting Type of Confidence Interval\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadaette &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadaette &lt;- df_explicit_na(adaette)\n\n# Create analysis dataset anl from the 2 parameters AEREPTTE & AETOT1\nanl_events &lt;- adaette %&gt;%\n  filter(PARAMCD == \"AETOT1\") %&gt;%\n  select(USUBJID, ARM, ARMCD, n_events = AVAL) %&gt;%\n  mutate(n_events = as.integer(n_events))\n\nanl_tte &lt;- adaette %&gt;%\n  filter(PARAMCD == \"AEREPTTE\") %&gt;%\n  select(USUBJID, ARM, ARMCD, AVAL)\n\nanl &lt;- full_join(anl_tte, anl_events, by = c(\"USUBJID\", \"ARM\", \"ARMCD\"))\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  estimate_incidence_rate(\n    vars = \"AVAL\",\n    n_events = \"n_events\",\n    control = control_incidence_rate(num_pt_year = 100)\n  )\n\nresult &lt;- build_table(lyt, anl, alt_counts_df = adsl)\nresult\n\n                                       A: Drug X         B: Placebo       C: Combination \n                                        (N=134)           (N=134)            (N=132)     \n—————————————————————————————————————————————————————————————————————————————————————————\nTotal patient-years at risk              337.9             331.8              341.6      \nNumber of adverse events observed         343               380                397       \nAE rate per 100 patient-years           101.51             114.51             116.22     \n95% CI                              (90.77, 112.25)   (103.00, 126.02)   (104.79, 127.65)\n\n\n\n\nThe type of confidence interval can be specified through the conf_type argument.\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  estimate_incidence_rate(\n    vars = \"AVAL\",\n    n_events = \"n_events\",\n    control = control_incidence_rate(conf_type = \"exact\", num_pt_year = 100)\n  )\n\nresult &lt;- build_table(lyt, anl, alt_counts_df = adsl)\nresult\n\n                                       A: Drug X         B: Placebo       C: Combination \n                                        (N=134)           (N=134)            (N=132)     \n—————————————————————————————————————————————————————————————————————————————————————————\nTotal patient-years at risk              337.9             331.8              341.6      \nNumber of adverse events observed         343               380                397       \nAE rate per 100 patient-years           101.51             114.51             116.22     \n95% CI                              (91.05, 112.84)   (103.28, 126.62)   (105.07, 128.24)\n\n\n\n\n\nCodelibrary(teal)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadaette &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadaette &lt;- df_explicit_na(adaette)\n\n# Create analysis dataset anl from the 2 parameters AEREPTTE & AETOT1\nanl_events &lt;- adaette %&gt;%\n  filter(PARAMCD %in% c(\"AETOT1\", \"AETOT2\", \"AETOT3\")) %&gt;%\n  select(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, n_events = AVAL) %&gt;%\n  mutate(n_events = as.integer(n_events))\n\nanl_tte &lt;- adaette %&gt;%\n  filter(PARAMCD == \"AEREPTTE\") %&gt;%\n  select(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)\n\nadaette &lt;- full_join(anl_tte, anl_events, by = c(\"USUBJID\", \"STUDYID\", \"ARM\", \"ARMCD\"))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADAETTE\", adaette),\n    code =\n      'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n      ADAETTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n      ADSL &lt;- df_explicit_na(ADSL)\n      ADAETTE &lt;- df_explicit_na(ADAETTE)\n      anl_events &lt;- ADAETTE %&gt;%\n        filter(PARAMCD %in%  c(\"AETOT1\", \"AETOT2\", \"AETOT3\")) %&gt;%\n        select(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, n_events = AVAL) %&gt;%\n        mutate(n_events = as.integer(n_events))\n      anl_tte &lt;- ADAETTE %&gt;%\n        filter(PARAMCD == \"AEREPTTE\") %&gt;%\n        select(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)\n      ADAETTE &lt;- full_join(anl_tte, anl_events, by = c(\"USUBJID\", \"STUDYID\", \"ARM\", \"ARMCD\"))',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_patyear(\n      label = \"AE Rate Adjusted for Patient-Years at Risk - All Occurrences Table\",\n      dataname = \"ADAETTE\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARMCD\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adaette, \"PARAMCD\"),\n        selected = \"AETOT1\"\n      ),\n      events_var = choices_selected(\n        choices = variable_choices(adaette, \"n_events\"),\n        selected = \"n_events\",\n        fixed = TRUE\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:17:40.9119 pid:10605 token:[] teal.modules.clinical Initializing tm_t_events_patyear\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet09.html",
+    "href": "tables/adverse-events/aet09.html",
+    "title": "AET09",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Including High-Level Terms\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nadae_labels &lt;- var_labels(adae)\n\nadae_f &lt;- adae %&gt;%\n  filter(AEREL == \"Y\")\n\nvar_labels(adae_f) &lt;- adae_labels\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event related to study drug\",\n      nonunique = \"Overall total number of events related to study drug\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_f$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event related to study drug\",\n      nonunique = \"Total number of events related to study drug\"\n    )\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = -1L\n  ) %&gt;%\n  append_varlabels(adae_f, \"AEDECOD\", indent = 1L)\n\ntbl1 &lt;- build_table(\n  lyt = lyt,\n  df = adae_f,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table()\n\nresult &lt;- tbl1 %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                                          A: Drug X    B: Placebo    C: Combination   All Patients\n  Dictionary-Derived Term                                                            (N=134)       (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event related to study drug     105 (78.4%)   108 (80.6%)    109 (82.6%)     322 (80.5%) \nOverall total number of events related to study drug                                   282           299            336             917     \ncl D.2                                                                                                                                      \n  Total number of patients with at least one adverse event related to study drug   47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) \n  Total number of events related to study drug                                         62            72              74             208     \n  dcd D.2.1.5.3                                                                    47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) \ncl D.1                                                                                                                                      \n  Total number of patients with at least one adverse event related to study drug   50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) \n  Total number of events related to study drug                                         61            51              71             183     \n  dcd D.1.1.1.1                                                                    50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) \ncl B.1                                                                                                                                      \n  Total number of patients with at least one adverse event related to study drug   47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) \n  Total number of events related to study drug                                         56            60              62             178     \n  dcd B.1.1.1.1                                                                    47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) \ncl C.2                                                                                                                                      \n  Total number of patients with at least one adverse event related to study drug   35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) \n  Total number of events related to study drug                                         48            53              65             166     \n  dcd C.2.1.2.1                                                                    35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) \ncl C.1                                                                                                                                      \n  Total number of patients with at least one adverse event related to study drug   43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) \n  Total number of events related to study drug                                         55            63              64             182     \n  dcd C.1.1.1.3                                                                    43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event related to study drug\",\n      nonunique = \"Overall total number of events related to study drug\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    indent_mod = 1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_f$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event related to study drug\",\n      nonunique = \"Total number of events related to study drug\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEHLT\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_f$AEHLT)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event related to study drug\",\n      nonunique = \"Total number of events related to study drug\"\n    )\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = c(count_fraction = -1L)\n  ) %&gt;%\n  append_varlabels(adae_f, c(\"AEDECOD\"), indent = 2L)\n\ntbl2 &lt;- build_table(\n  lyt = lyt,\n  df = adae_f,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table()\n\nresult &lt;- tbl2 %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                                                                                       \n  High Level Term                                                                       A: Drug X    B: Placebo    C: Combination\n    Dictionary-Derived Term                                                              (N=134)       (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event related to study drug         105 (78.4%)   108 (80.6%)    109 (82.6%)  \nOverall total number of events related to study drug                                       282           299            336      \n  cl D.2                                                                                                                         \n    Total number of patients with at least one adverse event related to study drug     47 (35.1%)    58 (43.3%)      57 (43.2%)  \n    Total number of events related to study drug                                           62            72              74      \n    hlt D.2.1.5                                                                                                                  \n      Total number of patients with at least one adverse event related to study drug   47 (35.1%)    58 (43.3%)      57 (43.2%)  \n      Total number of events related to study drug                                         62            72              74      \n      dcd D.2.1.5.3                                                                    47 (35.1%)    58 (43.3%)      57 (43.2%)  \n  cl D.1                                                                                                                         \n    Total number of patients with at least one adverse event related to study drug     50 (37.3%)    42 (31.3%)      51 (38.6%)  \n    Total number of events related to study drug                                           61            51              71      \n    hlt D.1.1.1                                                                                                                  \n      Total number of patients with at least one adverse event related to study drug   50 (37.3%)    42 (31.3%)      51 (38.6%)  \n      Total number of events related to study drug                                         61            51              71      \n      dcd D.1.1.1.1                                                                    50 (37.3%)    42 (31.3%)      51 (38.6%)  \n  cl B.1                                                                                                                         \n    Total number of patients with at least one adverse event related to study drug     47 (35.1%)    49 (36.6%)      43 (32.6%)  \n    Total number of events related to study drug                                           56            60              62      \n    hlt B.1.1.1                                                                                                                  \n      Total number of patients with at least one adverse event related to study drug   47 (35.1%)    49 (36.6%)      43 (32.6%)  \n      Total number of events related to study drug                                         56            60              62      \n      dcd B.1.1.1.1                                                                    47 (35.1%)    49 (36.6%)      43 (32.6%)  \n  cl C.2                                                                                                                         \n    Total number of patients with at least one adverse event related to study drug     35 (26.1%)    48 (35.8%)      55 (41.7%)  \n    Total number of events related to study drug                                           48            53              65      \n    hlt C.2.1.2                                                                                                                  \n      Total number of patients with at least one adverse event related to study drug   35 (26.1%)    48 (35.8%)      55 (41.7%)  \n      Total number of events related to study drug                                         48            53              65      \n      dcd C.2.1.2.1                                                                    35 (26.1%)    48 (35.8%)      55 (41.7%)  \n  cl C.1                                                                                                                         \n    Total number of patients with at least one adverse event related to study drug     43 (32.1%)    46 (34.3%)      43 (32.6%)  \n    Total number of events related to study drug                                           55            63              64      \n    hlt C.1.1.1                                                                                                                  \n      Total number of patients with at least one adverse event related to study drug   43 (32.1%)    46 (34.3%)      43 (32.6%)  \n      Total number of events related to study drug                                         55            63              64      \n      dcd C.1.1.1.3                                                                    43 (32.1%)    46 (34.3%)      43 (32.6%)  \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'\n    ),\n    cdisc_dataset(\n      \"ADAE\",\n      adae,\n      code = 'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adae\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Adverse Events Related to Study Drug\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AEHLT\")),\n        selected = c(\"AEBODSYS\")\n      ),\n      add_total = FALSE,\n      event_type = \"adverse event related to study drug\", # define event type here\n    )\n  ),\n  filter = list(ADAE = list(AEREL = \"Y\")) # related AEs only\n)\n\n[INFO] 2023-09-25 11:16:34.0655 pid:10409 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet10.html",
+    "href": "tables/adverse-events/aet10.html",
+    "title": "AET10",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nMost Common (\\(\\geq\\) 35%) Adverse Events (setting threshold)\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\n\n\n\nThe “All Patients” column is not required in this table but for illustrative purposes we include it to show correct sorting.\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    var = \"ARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\")\n\ntbl1 &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n)\n\ntbl2 &lt;- prune_table(\n  tt = tbl1,\n  prune_func = keep_rows(\n    has_fraction_in_any_col(\n      atleast = 0.05, # specify threshold\n      col_names = levels(adsl$ARM)\n    )\n  )\n)\n\nresult &lt;- sort_at_path(\n  tbl2,\n  path = c(\"AEDECOD\"),\n  scorefun = score_occurrences\n)\n\nresult\n\n                A: Drug X    B: Placebo   C: Combination   All Patients\n                 (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————\ndcd D.2.1.5.3   47 (35.1%)   58 (43.3%)     57 (43.2%)     162 (40.5%) \ndcd A.1.1.1.1   50 (37.3%)   45 (33.6%)     63 (47.7%)     158 (39.5%) \ndcd B.2.2.3.1   48 (35.8%)   54 (40.3%)     51 (38.6%)     153 (38.2%) \ndcd A.1.1.1.2   48 (35.8%)   48 (35.8%)     50 (37.9%)     146 (36.5%) \ndcd B.2.1.2.1   49 (36.6%)   44 (32.8%)     52 (39.4%)     145 (36.2%) \ndcd D.1.1.1.1   50 (37.3%)   42 (31.3%)     51 (38.6%)     143 (35.8%) \ndcd D.1.1.4.2   48 (35.8%)   42 (31.3%)     50 (37.9%)     140 (35.0%) \ndcd B.1.1.1.1   47 (35.1%)   49 (36.6%)     43 (32.6%)     139 (34.8%) \ndcd C.2.1.2.1   35 (26.1%)   48 (35.8%)     55 (41.7%)     138 (34.5%) \ndcd C.1.1.1.3   43 (32.1%)   46 (34.3%)     43 (32.6%)     132 (33.0%) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    var = \"ARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\")\n\ntbl1 &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n)\n\ntbl2 &lt;- prune_table(\n  tt = tbl1,\n  prune_func = keep_rows(\n    has_fraction_in_any_col(\n      atleast = 0.35, # specify threshold\n      col_names = levels(adsl$ARM)\n    )\n  )\n)\n\nresult &lt;- sort_at_path(\n  tbl2,\n  path = c(\"AEDECOD\"),\n  scorefun = score_occurrences\n)\n\nresult\n\n                A: Drug X    B: Placebo   C: Combination   All Patients\n                 (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————\ndcd D.2.1.5.3   47 (35.1%)   58 (43.3%)     57 (43.2%)     162 (40.5%) \ndcd A.1.1.1.1   50 (37.3%)   45 (33.6%)     63 (47.7%)     158 (39.5%) \ndcd B.2.2.3.1   48 (35.8%)   54 (40.3%)     51 (38.6%)     153 (38.2%) \ndcd A.1.1.1.2   48 (35.8%)   48 (35.8%)     50 (37.9%)     146 (36.5%) \ndcd B.2.1.2.1   49 (36.6%)   44 (32.8%)     52 (39.4%)     145 (36.2%) \ndcd D.1.1.1.1   50 (37.3%)   42 (31.3%)     51 (38.6%)     143 (35.8%) \ndcd D.1.1.4.2   48 (35.8%)   42 (31.3%)     50 (37.9%)     140 (35.0%) \ndcd B.1.1.1.1   47 (35.1%)   49 (36.6%)     43 (32.6%)     139 (34.8%) \ndcd C.2.1.2.1   35 (26.1%)   48 (35.8%)     55 (41.7%)     138 (34.5%) \n\n\n\n\nThe desired frequency is specified in prune_freq. For illustration, frequency is set to \\(\\geq\\) 35%.\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADAE\", adae, code = 'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adae\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Adverse Event Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = NULL\n      ),\n      add_total = TRUE,\n      event_type = \"adverse event\",\n      prune_freq = 35,\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:15:27.6157 pid:10213 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/medical-history/mht01.html",
+    "href": "tables/medical-history/mht01.html",
+    "title": "MHT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable of History  Prior to Study\nTable with Total Number  of Conditions Suppressed\nTable with Total Number of Conditions Per Body  System After The Summary of Patients\nTable Showing Additional  “All Patients” Column\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadmh &lt;- synthetic_cdisc_dataset(\"latest\", \"admh\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadmh &lt;- df_explicit_na(admh)\n\nadsl_f &lt;- adsl %&gt;%\n  filter(SAFFL == \"Y\") %&gt;%\n  select(USUBJID, ACTARM)\n\nadmh_f &lt;- admh %&gt;%\n  filter(SAFFL == \"Y\" & MHBODSYS != \"\" & MHDECOD != \"\") %&gt;%\n  var_relabel(\n    MHBODSYS = \"MedDRA System Organ Class\",\n    MHDECOD = \"MedDRA Preferred Term\"\n  )\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\"Total number of patients with at least one condition\", \"Total number of conditions\")\n  ) %&gt;%\n  split_rows_by(\n    var = \"MHBODSYS\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(admh_f$MHBODSYS)\n  ) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\"Total number of patients with at least one condition\", \"Total number of conditions\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(vars = \"MHDECOD\") %&gt;%\n  append_varlabels(admh_f, \"MHDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, admh_f, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nMedDRA System Organ Class                                 A: Drug X    B: Placebo    C: Combination\n  MedDRA Preferred Term                                    (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one condition     122 (91.0%)   123 (91.8%)    120 (90.9%)  \nTotal number of conditions                                   609           622            703      \ncl A                                                                                               \n  Total number of patients with at least one condition   78 (58.2%)    75 (56.0%)      89 (67.4%)  \n  Total number of conditions                                 132           130            160      \n  trm A_1/2                                              50 (37.3%)    45 (33.6%)      63 (47.7%)  \n  trm A_2/2                                              48 (35.8%)    48 (35.8%)      50 (37.9%)  \ncl B                                                                                               \n  Total number of patients with at least one condition   96 (71.6%)    89 (66.4%)      97 (73.5%)  \n  Total number of conditions                                 185           198            205      \n  trm B_1/3                                              47 (35.1%)    49 (36.6%)      43 (32.6%)  \n  trm B_2/3                                              49 (36.6%)    44 (32.8%)      52 (39.4%)  \n  trm B_3/3                                              48 (35.8%)    54 (40.3%)      51 (38.6%)  \ncl C                                                                                               \n  Total number of patients with at least one condition   67 (50.0%)    75 (56.0%)      79 (59.8%)  \n  Total number of conditions                                 103           116            129      \n  trm C_1/2                                              43 (32.1%)    46 (34.3%)      43 (32.6%)  \n  trm C_2/2                                              35 (26.1%)    48 (35.8%)      55 (41.7%)  \ncl D                                                                                               \n  Total number of patients with at least one condition   96 (71.6%)    90 (67.2%)      98 (74.2%)  \n  Total number of conditions                                 189           178            209      \n  trm D_1/3                                              50 (37.3%)    42 (31.3%)      51 (38.6%)  \n  trm D_2/3                                              48 (35.8%)    42 (31.3%)      50 (37.9%)  \n  trm D_3/3                                              47 (35.1%)    58 (43.3%)      57 (43.2%)  \n\n\n\n\n\nCodeadmh_f_prior &lt;- admh_f %&gt;%\n  filter(ASTDY &lt;= 0)\n\nresult &lt;- build_table(lyt, admh_f_prior, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nMedDRA System Organ Class                                A: Drug X   B: Placebo   C: Combination\n  MedDRA Preferred Term                                   (N=134)     (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one condition         0           0           1 (0.8%)   \nTotal number of conditions                                   0           0              1       \ncl D                                                                                            \n  Total number of patients with at least one condition       0           0           1 (0.8%)   \n  Total number of conditions                                 0           0              1       \n  trm D_2/3                                                  0           0           1 (0.8%)   \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\"Total number of patients with at least one condition\")\n  ) %&gt;%\n  split_rows_by(\n    var = \"MHBODSYS\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(admh_f$MHBODSYS)\n  ) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\"Total number of patients with at least one condition\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(vars = \"MHDECOD\") %&gt;%\n  append_varlabels(admh_f, \"MHDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt, admh_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\nMedDRA System Organ Class                                 A: Drug X    B: Placebo    C: Combination\n  MedDRA Preferred Term                                    (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one condition     122 (91.0%)   123 (91.8%)    120 (90.9%)  \ncl A                                                                                               \n  Total number of patients with at least one condition   78 (58.2%)    75 (56.0%)      89 (67.4%)  \n  trm A_1/2                                              50 (37.3%)    45 (33.6%)      63 (47.7%)  \n  trm A_2/2                                              48 (35.8%)    48 (35.8%)      50 (37.9%)  \ncl B                                                                                               \n  Total number of patients with at least one condition   96 (71.6%)    89 (66.4%)      97 (73.5%)  \n  trm B_1/3                                              47 (35.1%)    49 (36.6%)      43 (32.6%)  \n  trm B_2/3                                              49 (36.6%)    44 (32.8%)      52 (39.4%)  \n  trm B_3/3                                              48 (35.8%)    54 (40.3%)      51 (38.6%)  \ncl C                                                                                               \n  Total number of patients with at least one condition   67 (50.0%)    75 (56.0%)      79 (59.8%)  \n  trm C_1/2                                              43 (32.1%)    46 (34.3%)      43 (32.6%)  \n  trm C_2/2                                              35 (26.1%)    48 (35.8%)      55 (41.7%)  \ncl D                                                                                               \n  Total number of patients with at least one condition   96 (71.6%)    90 (67.2%)      98 (74.2%)  \n  trm D_1/3                                              50 (37.3%)    42 (31.3%)      51 (38.6%)  \n  trm D_2/3                                              48 (35.8%)    42 (31.3%)      50 (37.9%)  \n  trm D_3/3                                              47 (35.1%)    58 (43.3%)      57 (43.2%)  \n\n\n\n\nNot currently supported by rtables. Users, please notify us if this variation is important to you.\n\n\nConditions are further sorted by decreasing high level terms and low level terms.\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  analyze_num_patients(\n    \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(unique = \"Total number of patients with at least one event\", nonunique = \"Total number of conditions\")\n  ) %&gt;%\n  split_rows_by(\n    var = \"MHBODSYS\",\n    split_fun = split_fun,\n    child_labels = \"visible\",\n    label_pos = \"topleft\",\n    split_label = obj_label(admh_f$MHBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(unique = \"Total number of patients with at least one event\", nonunique = \"Total number of conditions\")\n  ) %&gt;%\n  count_occurrences(vars = \"MHDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(admh_f, \"MHDECOD\", indent = 1L)\n\nscorefun_hlt &lt;- cont_n_allcols\nscorefun_llt &lt;- score_occurrences_cols(col_indices = nlevels(adsl_f$ACTARM) + 1)\n\nresult &lt;- build_table(lyt, admh_f, alt_counts_df = adsl_f) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(path = c(\"MHBODSYS\"), scorefun = scorefun_hlt) %&gt;%\n  sort_at_path(path = c(\"MHBODSYS\", \"*\", \"MHDECOD\"), scorefun = scorefun_llt)\n\nresult\n\nMedDRA System Organ Class                             A: Drug X    B: Placebo    C: Combination   All Patients\n  MedDRA Preferred Term                                (N=134)       (N=134)        (N=132)         (N=400)   \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one event     122 (91.0%)   123 (91.8%)    120 (90.9%)     365 (91.2%) \nTotal number of conditions                               609           622            703             1934    \ncl D                                                                                                          \n  Total number of patients with at least one event   96 (71.6%)    90 (67.2%)      98 (74.2%)     284 (71.0%) \n  Total number of conditions                             189           178            209             576     \n  trm D_3/3                                          47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) \n  trm D_1/3                                          50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) \n  trm D_2/3                                          48 (35.8%)    42 (31.3%)      50 (37.9%)     140 (35.0%) \ncl B                                                                                                          \n  Total number of patients with at least one event   96 (71.6%)    89 (66.4%)      97 (73.5%)     282 (70.5%) \n  Total number of conditions                             185           198            205             588     \n  trm B_3/3                                          48 (35.8%)    54 (40.3%)      51 (38.6%)     153 (38.2%) \n  trm B_2/3                                          49 (36.6%)    44 (32.8%)      52 (39.4%)     145 (36.2%) \n  trm B_1/3                                          47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) \ncl A                                                                                                          \n  Total number of patients with at least one event   78 (58.2%)    75 (56.0%)      89 (67.4%)     242 (60.5%) \n  Total number of conditions                             132           130            160             422     \n  trm A_1/2                                          50 (37.3%)    45 (33.6%)      63 (47.7%)     158 (39.5%) \n  trm A_2/2                                          48 (35.8%)    48 (35.8%)      50 (37.9%)     146 (36.5%) \ncl C                                                                                                          \n  Total number of patients with at least one event   67 (50.0%)    75 (56.0%)      79 (59.8%)     221 (55.2%) \n  Total number of conditions                             103           116            129             348     \n  trm C_2/2                                          35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) \n  trm C_1/2                                          43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl_f &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n  filter(SAFFL == \"Y\")\nadmh_f &lt;- synthetic_cdisc_dataset(\"latest\", \"admh\") %&gt;%\n  filter(SAFFL == \"Y\" & MHBODSYS != \"\" & MHDECOD != \"\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl_f, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n                  filter(SAFFL == \"Y\")'),\n    cdisc_dataset(\"ADMH\", admh_f, code = 'ADMH &lt;- synthetic_cdisc_dataset(\"latest\", \"admh\") %&gt;%\n                  filter(SAFFL == \"Y\" & MHBODSYS != \"\" & MHDECOD != \"\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Medical History Table\",\n      dataname = \"ADMH\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(admh_f, c(\"MHTERM\", \"MHDECOD\")),\n        selected = c(\"MHDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(admh_f, c(\"MHBODSYS\", \"MHSOC\")),\n        selected = \"MHBODSYS\"\n      ),\n      add_total = TRUE,\n      event_type = \"condition\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:14:18.5420 pid:10017 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ECG/egt02.html",
+    "href": "tables/ECG/egt02.html",
+    "title": "EGT02",
+    "section": "",
+    "text": "Data Setup\nECG Abnormalities Regardless  of Abnormality at Baseline\nECG Abnormalities Among Subjects  Without Abnormality at Baseline\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg)\n\n# Note:  We keep only post-baseline for analysis.\nadeg_f &lt;- adeg %&gt;%\n  filter(ONTRTFL == \"Y\") %&gt;%\n  filter(PARAM %in% c(\"Heart Rate\", \"QT Duration\", \"RR Duration\")) %&gt;%\n  filter(ANRIND != \"&lt;Missing&gt;\") %&gt;%\n  var_relabel(\n    PARAM = \"Assessment\",\n    ANRIND = \"Abnormality\"\n  )\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adeg_f$PARAM)\n  ) %&gt;%\n  count_abnormal(\"ANRIND\", abnormal = list(Low = \"LOW\", High = \"HIGH\"), exclude_base_abn = FALSE) %&gt;%\n  append_varlabels(adeg_f, \"ANRIND\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adeg_f, alt_counts_df = adsl)\nresult\n\nAssessment        A: Drug X        B: Placebo     C: Combination\n  Abnormality      (N=134)          (N=134)          (N=132)    \n————————————————————————————————————————————————————————————————\nHeart Rate                                                      \n  Low           40/134 (29.9%)   43/134 (32.1%)    37/132 (28%) \n  High          39/134 (29.1%)   45/134 (33.6%)   36/132 (27.3%)\nQT Duration                                                     \n  Low           33/134 (24.6%)   44/134 (32.8%)   47/132 (35.6%)\n  High          30/134 (22.4%)   42/134 (31.3%)   34/132 (25.8%)\nRR Duration                                                     \n  Low           45/134 (33.6%)   26/134 (19.4%)   38/132 (28.8%)\n  High          29/134 (21.6%)   49/134 (36.6%)   27/132 (20.5%)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adeg_f$PARAM)\n  ) %&gt;%\n  count_abnormal(\"ANRIND\", abnormal = list(Low = \"LOW\", High = \"HIGH\"), exclude_base_abn = TRUE) %&gt;%\n  append_varlabels(adeg_f, \"ANRIND\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adeg_f, alt_counts_df = adsl)\nresult\n\nAssessment        A: Drug X        B: Placebo     C: Combination\n  Abnormality      (N=134)          (N=134)          (N=132)    \n————————————————————————————————————————————————————————————————\nHeart Rate                                                      \n  Low           39/128 (30.5%)   42/124 (33.9%)   33/117 (28.2%)\n  High          37/127 (29.1%)   43/129 (33.3%)   31/122 (25.4%)\nQT Duration                                                     \n  Low           29/113 (25.7%)   42/126 (33.3%)   43/124 (34.7%)\n  High           30/125 (24%)    40/130 (30.8%)   30/119 (25.2%)\nRR Duration                                                     \n  Low           45/129 (34.9%)   26/123 (21.1%)   37/126 (29.4%)\n  High          27/127 (21.3%)   43/122 (35.2%)    25/125 (20%) \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADEG\", adeg, code = 'ADEG &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_abnormality(\n      label = \"Abnormality Table\",\n      dataname = \"ADEG\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adeg, subset = c(\"EGCAT\", \"PARAM\", \"AVISIT\")),\n        selected = c(\"PARAM\"),\n        keep_order = TRUE\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adeg, subset = \"ANRIND\"),\n        selected = \"ANRIND\",\n        fixed = TRUE\n      ),\n      abnormal = list(Low = \"LOW\", High = \"HIGH\"),\n      exclude_base_abn = FALSE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:13:30.3009 pid:9868 token:[] teal.modules.clinical Initializing tm_t_abnormality\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] scda_0.1.6                   dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ECG/egt05_qtcat.html",
+    "href": "tables/ECG/egt05_qtcat.html",
+    "title": "EGT05_QTCAT",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg)\n\nadeg_labels &lt;- var_labels(adeg)\nadeg_f &lt;- adeg %&gt;%\n  filter(\n    PARAMCD == \"QT\",\n    ANL01FL == \"Y\"\n  ) %&gt;%\n  mutate(\n    AVALCAT1 = case_when(\n      AVAL &lt;= 450 ~ \"&lt;=450 msec\",\n      AVAL &lt;= 480 ~ \"&gt;450 to &lt;=480 msec\",\n      AVAL &lt;= 500 ~ \"&gt;480 to &lt;= 500 msec\",\n      AVAL &gt; 500 ~ \"&gt;500 msec\",\n      is.na(AVAL) ~ \"&lt;Missing&gt;\"\n    ),\n    CHGCAT1 = case_when(\n      CHG &lt;= 30 ~ \"&lt;=30 msec\",\n      CHG &lt;= 60 ~ \"&gt;30 to &lt;=60 msec\",\n      CHG &gt; 60 ~ \"&gt;60 msec\",\n      is.na(CHG) ~ \"&lt;Missing&gt;\"\n    )\n  ) %&gt;%\n  mutate(\n    AVALCAT1 = factor(\n      AVALCAT1,\n      levels = c(\n        \"&lt;=450 msec\",\n        \"&gt;450 to &lt;=480 msec\",\n        \"&gt;480 to &lt;= 500 msec\",\n        \"&gt;500 msec\",\n        \"&lt;Missing&gt;\"\n      )\n    ),\n    CHGCAT1 = factor(\n      CHGCAT1,\n      levels = c(\n        \"&lt;=30 msec\",\n        \"&gt;30 to &lt;=60 msec\",\n        \"&gt;60 msec\",\n        \"&lt;Missing&gt;\"\n      )\n    )\n  ) %&gt;%\n  var_relabel(\n    AVALCAT1 = \"Value at Visit\",\n    CHGCAT1 = \"Change from Baseline\"\n  )\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_label = obj_label(adeg_f$PARAM),\n    split_fun = split_fun,\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_label = obj_label(adeg_f$AVISIT),\n    split_fun = split_fun,\n    label_pos = \"topleft\"\n  ) %&gt;%\n  analyze_vars(\n    vars = c(\"AVALCAT1\", \"CHGCAT1\"),\n    var_labels = c(\"Value at Visit\", \"Change from Baseline\")\n  ) %&gt;%\n  append_topleft(\"    Category\")\n\nresult &lt;- build_table(lyt = lyt, df = adeg_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\nParameter                                                             \n  Analysis Visit             A: Drug X    B: Placebo    C: Combination\n    Category                  (N=134)       (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————\nQT Duration                                                           \n  BASELINE                                                            \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            115 (85.8%)   117 (87.3%)    104 (78.8%)  \n      &gt;450 to &lt;=480 msec     6 (4.5%)      10 (7.5%)       9 (6.8%)   \n      &gt;480 to &lt;= 500 msec     4 (3%)       3 (2.2%)        6 (4.5%)   \n      &gt;500 msec              9 (6.7%)       4 (3%)        13 (9.8%)   \n  WEEK 1 DAY 8                                                        \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            113 (84.3%)   106 (79.1%)    106 (80.3%)  \n      &gt;450 to &lt;=480 msec     10 (7.5%)     10 (7.5%)      11 (8.3%)   \n      &gt;480 to &lt;= 500 msec     4 (3%)        4 (3%)         3 (2.3%)   \n      &gt;500 msec              7 (5.2%)     14 (10.4%)      12 (9.1%)   \n    Change from Baseline                                              \n      n                         134           134            132      \n      &lt;=30 msec             76 (56.7%)     75 (56%)       75 (56.8%)  \n      &gt;30 to &lt;=60 msec       7 (5.2%)      13 (9.7%)      11 (8.3%)   \n      &gt;60 msec              51 (38.1%)    46 (34.3%)      46 (34.8%)  \n  WEEK 2 DAY 15                                                       \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            111 (82.8%)   114 (85.1%)    112 (84.8%)  \n      &gt;450 to &lt;=480 msec     10 (7.5%)     9 (6.7%)        9 (6.8%)   \n      &gt;480 to &lt;= 500 msec    7 (5.2%)      2 (1.5%)        5 (3.8%)   \n      &gt;500 msec              6 (4.5%)      9 (6.7%)        6 (4.5%)   \n    Change from Baseline                                              \n      n                         134           134            132      \n      &lt;=30 msec              71 (53%)     87 (64.9%)      89 (67.4%)  \n      &gt;30 to &lt;=60 msec       11 (8.2%)     9 (6.7%)        9 (6.8%)   \n      &gt;60 msec              52 (38.8%)    38 (28.4%)      34 (25.8%)  \n  WEEK 3 DAY 22                                                       \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            106 (79.1%)   112 (83.6%)    118 (89.4%)  \n      &gt;450 to &lt;=480 msec     13 (9.7%)     7 (5.2%)        3 (2.3%)   \n      &gt;480 to &lt;= 500 msec     4 (3%)       5 (3.7%)        2 (1.5%)   \n      &gt;500 msec              11 (8.2%)     10 (7.5%)       9 (6.8%)   \n    Change from Baseline                                              \n      n                         134           134            132      \n      &lt;=30 msec              63 (47%)     80 (59.7%)      81 (61.4%)  \n      &gt;30 to &lt;=60 msec      14 (10.4%)      8 (6%)        11 (8.3%)   \n      &gt;60 msec              57 (42.5%)    46 (34.3%)      40 (30.3%)  \n  WEEK 4 DAY 29                                                       \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            117 (87.3%)   103 (76.9%)    114 (86.4%)  \n      &gt;450 to &lt;=480 msec     7 (5.2%)     14 (10.4%)       6 (4.5%)   \n      &gt;480 to &lt;= 500 msec     4 (3%)       7 (5.2%)        3 (2.3%)   \n      &gt;500 msec              6 (4.5%)      10 (7.5%)       9 (6.8%)   \n    Change from Baseline                                              \n      n                         134           134            132      \n      &lt;=30 msec              79 (59%)     80 (59.7%)      79 (59.8%)  \n      &gt;30 to &lt;=60 msec       11 (8.2%)     7 (5.2%)       10 (7.6%)   \n      &gt;60 msec              44 (32.8%)    47 (35.1%)      43 (32.6%)  \n  WEEK 5 DAY 36                                                       \n    Value at Visit                                                    \n      n                         134           134            132      \n      &lt;=450 msec            107 (79.9%)   117 (87.3%)    112 (84.8%)  \n      &gt;450 to &lt;=480 msec    16 (11.9%)     5 (3.7%)       13 (9.8%)   \n      &gt;480 to &lt;= 500 msec    5 (3.7%)      9 (6.7%)        3 (2.3%)   \n      &gt;500 msec              6 (4.5%)      3 (2.2%)         4 (3%)    \n    Change from Baseline                                              \n      n                         134           134            132      \n      &lt;=30 msec             72 (53.7%)    82 (61.2%)      73 (55.3%)  \n      &gt;30 to &lt;=60 msec       10 (7.5%)     11 (8.2%)      11 (8.3%)   \n      &gt;60 msec              52 (38.8%)    41 (30.6%)      48 (36.4%)  \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg)\nadeg_labels &lt;- var_labels(adeg)\n\nadeg_f &lt;- adeg %&gt;%\n  filter(\n    ANL01FL == \"Y\" # no need to filter for PARAMCD here\n  ) %&gt;%\n  mutate(\n    AVALCAT1 = case_when(\n      AVAL &lt;= 450 ~ \"&lt;=450 msec\",\n      AVAL &lt;= 480 ~ \"&gt;450 to &lt;=480 msec\",\n      AVAL &lt;= 500 ~ \"&gt;480 to &lt;= 500 msec\",\n      AVAL &gt; 500 ~ \"&gt;500 msec\",\n      is.na(AVAL) ~ \"&lt;Missing&gt;\"\n    ),\n    CHGCAT1 = case_when(\n      CHG &lt;= 30 ~ \"&lt;=30 msec\",\n      CHG &lt;= 60 ~ \"&gt;30 to &lt;=60 msec\",\n      CHG &gt; 60 ~ \"&gt;60 msec\",\n      is.na(CHG) ~ \"&lt;Missing&gt;\"\n    )\n  ) %&gt;%\n  mutate(\n    AVALCAT1 = factor(\n      AVALCAT1,\n      levels = c(\n        \"&lt;=450 msec\",\n        \"&gt;450 to &lt;=480 msec\",\n        \"&gt;480 to &lt;= 500 msec\",\n        \"&gt;500 msec\",\n        \"&lt;Missing&gt;\"\n      )\n    ),\n    CHGCAT1 = factor(\n      CHGCAT1,\n      levels = c(\n        \"&lt;=30 msec\",\n        \"&gt;30 to &lt;=60 msec\",\n        \"&gt;60 msec\",\n        \"&lt;Missing&gt;\"\n      )\n    )\n  )\nvar_labels(adeg_f) &lt;- c(\n  adeg_labels,\n  \"AVALCAT1\" = \"Value at Visit\",\n  \"CHGCAT1\" = \"Change from Baseline\"\n)\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n                  ADSL &lt;- df_explicit_na(ADSL)'\n    ),\n    cdisc_dataset(\"ADEG\",\n      adeg_f,\n      code = 'ADEG &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n                  ADEG &lt;- df_explicit_na(ADEG)\n                  ADEG_labels &lt;- var_labels(ADEG)\n\n                  ADEG &lt;- ADEG %&gt;%\n                    filter(\n                      ANL01FL == \"Y\"\n                    ) %&gt;%\n                     mutate(\n                      AVALCAT1 = case_when(\n                        AVAL &lt;= 450 ~ \"&lt;=450 msec\",\n                        AVAL &lt;= 480 ~ \"&gt;450 to &lt;=480 msec\",\n                        AVAL &lt;= 500 ~ \"&gt;480 to &lt;= 500 msec\",\n                        AVAL &gt; 500 ~ \"&gt;500 msec\",\n                        is.na(AVAL) ~ \"&lt;Missing&gt;\"),\n                      CHGCAT1 = case_when(\n                        CHG &lt;= 30 ~ \"&lt;=30 msec\",\n                        CHG &lt;= 60 ~ \"&gt;30 to &lt;=60 msec\",\n                        CHG &gt; 60 ~ \"&gt;60 msec\",\n                        is.na(CHG) ~ \"&lt;Missing&gt;\")\n                    ) %&gt;% mutate(\n                      AVALCAT1 = factor(\n                        AVALCAT1,\n                        levels = c(\n                          \"&lt;=450 msec\",\n                          \"&gt;450 to &lt;=480 msec\",\n                          \"&gt;480 to &lt;= 500 msec\",\n                          \"&gt;500 msec\",\n                          \"&lt;Missing&gt;\"\n                        )\n                      ),\n                      CHGCAT1 = factor(\n                        CHGCAT1,\n                        levels = c(\n                          \"&lt;=30 msec\",\n                          \"&gt;30 to &lt;=60 msec\",\n                          \"&gt;60 msec\",\n                          \"&lt;Missing&gt;\"\n                        )\n                      )\n                    )\n                  var_labels(ADEG) &lt;- c(\n                    ADEG_labels,\n                    \"AVALCAT1\" = \"Value at Visit\",\n                    \"CHGCAT1\" = \"Change from Baseline\"\n                  )'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"ECG Actual Values and Changes from Baseline by Visit\",\n      dataname = \"ADEG\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adeg_f, c(\"PARAM\", \"AVISIT\")),\n        selected = c(\"AVISIT\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adeg_f, c(\"AVALCAT1\", \"CHGCAT1\")),\n        selected = c(\"AVALCAT1\", \"CHGCAT1\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adeg_f, \"PARAMCD\", \"PARAM\"),\n        selected = \"QT\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:12:10.1697 pid:9672 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt02.html",
+    "href": "tables/pharmacokinetic/pkpt02.html",
+    "title": "PKPT02",
+    "section": "",
+    "text": "Data Setup\nStandard Table – Plasma\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp &lt;- adpp %&gt;% filter(PPSPEC == \"Plasma\", AVISIT == \"CYCLE 1 DAY 1\")\n\n\n\n\n\nCode# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ARMCD\"),\n    # label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_label = \"PK Parameter\"\n  ) %&gt;%\n  tern::analyze_vars(\n    vars = \"AVAL\",\n    .stats = c(\"n\", \"mean_sd\", \"cv\", \"geom_mean\", \"geom_cv\", \"median\", \"range\"),\n    .formats = c(\n      n = \"xx.\",\n      mean_sd = sprintf_format(\"%.3e (%.3e)\"),\n      cv = \"xx.x\",\n      geom_mean = sprintf_format(\"%.3e\"),\n      geom_cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      range = sprintf_format(\"%.3e - %.3e\")\n    )\n  )\n\n\nPlasma Drug X\n\nCodeadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp0$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\nresult\n\nSummary of Plasma PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————————————————————————————\nPK Parameter                     ARM A                   ARM C        \n——————————————————————————————————————————————————————————————————————\nCmax (ug/mL)                                                          \n  n                               134                     132         \n  Mean (SD)              3.025e+01 (6.239e+00)   3.004e+01 (5.457e+00)\n  CV (%)                         20.6                    18.2         \n  Geometric Mean               2.961e+01               2.954e+01      \n  CV % Geometric Mean            21.0                    18.9         \n  Median                       2.986e+01               2.977e+01      \n  Min - Max              1.753e+01 - 4.871e+01   1.585e+01 - 4.757e+01\nAUCinf obs (day*ug/mL)                                                \n  n                               134                     132         \n  Mean (SD)              2.028e+02 (3.766e+01)   1.955e+02 (3.785e+01)\n  CV (%)                         18.6                    19.4         \n  Geometric Mean               1.994e+02               1.917e+02      \n  CV % Geometric Mean            18.7                    20.1         \n  Median                       1.971e+02               1.962e+02      \n  Min - Max              1.253e+02 - 3.110e+02   1.030e+02 - 3.145e+02\nCL obs (ml/day/kg)                                                    \n  n                               134                     132         \n  Mean (SD)              5.043e+00 (1.041e+00)   5.009e+00 (9.846e-01)\n  CV (%)                         20.6                    19.7         \n  Geometric Mean               4.929e+00               4.907e+00      \n  CV % Geometric Mean            22.4                    21.1         \n  Median                       5.078e+00               4.969e+00      \n  Min - Max              2.255e+00 - 7.395e+00   2.102e+00 - 7.489e+00\n\n\nPlasma Drug Y\n\nCodeadpp1 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug Y\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp1)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp1$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp1$PPCAT), \"\\nVisit:\", unique(adpp1$AVISIT))\nresult\n\nSummary of Plasma PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug Y \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————\nPK Parameter                     ARM C        \n——————————————————————————————————————————————\nCmax (ug/mL)                                  \n  n                               132         \n  Mean (SD)              2.990e+01 (5.550e+00)\n  CV (%)                         18.6         \n  Geometric Mean               2.935e+01      \n  CV % Geometric Mean            20.1         \n  Median                       2.969e+01      \n  Min - Max              1.406e+01 - 4.345e+01\nAUCinf obs (day*ug/mL)                        \n  n                               132         \n  Mean (SD)              1.986e+02 (3.792e+01)\n  CV (%)                         19.1         \n  Geometric Mean               1.952e+02      \n  CV % Geometric Mean            18.9         \n  Median                       1.953e+02      \n  Min - Max              1.264e+02 - 3.183e+02\nCL obs (ml/day/kg)                            \n  n                               132         \n  Mean (SD)              4.955e+00 (8.951e-01)\n  CV (%)                         18.1         \n  Geometric Mean               4.873e+00      \n  CV % Geometric Mean            18.7         \n  Median                       4.936e+00      \n  Min - Max              2.987e+00 - 7.211e+00\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      \n[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      \n[45] pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt03.html",
+    "href": "tables/pharmacokinetic/pkpt03.html",
+    "title": "PKPT03",
+    "section": "",
+    "text": "Data Setup\nteal App\nReproducibility\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nloaded via a namespace (and not attached):\n [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    \n [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  \n [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   \n[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    \n[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2\n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt06.html",
+    "href": "tables/pharmacokinetic/pkpt06.html",
+    "title": "PKPT06",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\nlibrary(stringr)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp &lt;- adpp %&gt;% filter(AVISIT == \"CYCLE 1 DAY 1\", str_detect(tolower(PARAM), regex(\"norm by dose\", ignore_case = TRUE)))\n\n\n\n\n\nCode# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ARMCD\"),\n    # label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_label = \"PK Parameter\"\n  ) %&gt;%\n  tern::analyze_vars(\n    vars = \"AVAL\",\n    .stats = c(\"n\", \"mean_sd\", \"cv\", \"geom_mean\", \"geom_cv\", \"median\", \"range\"),\n    .formats = c(\n      n = \"xx.\",\n      mean_sd = sprintf_format(\"%.3e (%.3e)\"),\n      cv = \"xx.x\",\n      geom_mean = sprintf_format(\"%.3e\"),\n      geom_cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      range = sprintf_format(\"%.3e - %.3e\")\n    )\n  )\n\n\nPlasma Drug X\n\nCodeadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\nresult\n\nSummary of Dose-Normalized PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n—————————————————————————————————————————————————————————————————————\nPK Parameter                    ARM A                   ARM C        \n—————————————————————————————————————————————————————————————————————\nRENALCLD (L/hr/mg)                                                   \n  n                              134                     132         \n  Mean (SD)             4.873e-03 (9.654e-04)   5.110e-03 (9.339e-04)\n  CV (%)                        19.8                    18.3         \n  Geometric Mean              4.772e-03               5.019e-03      \n  CV % Geometric Mean           21.2                    19.7         \n  Median                      4.967e-03               5.151e-03      \n  Min - Max             2.385e-03 - 7.258e-03   2.356e-03 - 7.407e-03\n\n\nPlasma Drug Y\n\nCodeadpp1 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug Y\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp1)\nmain_title(result) &lt;- paste(\"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp1$PPCAT), \"\\nVisit:\", unique(adpp1$AVISIT))\nresult\n\nSummary of Dose-Normalized PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug Y \nVisit: CYCLE 1 DAY 1\n\n—————————————————————————————————————————————\nPK Parameter                    ARM C        \n—————————————————————————————————————————————\nRENALCLD (L/hr/mg)                           \n  n                              132         \n  Mean (SD)             5.093e-03 (1.032e-03)\n  CV (%)                        20.3         \n  Geometric Mean              4.985e-03      \n  CV % Geometric Mean           21.4         \n  Median                      5.017e-03      \n  Min - Max             2.356e-03 - 7.939e-03\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] stringr_1.5.0    tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   stringi_1.7.12    broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt05.html",
+    "href": "tables/pharmacokinetic/pkpt05.html",
+    "title": "PKPT05",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp &lt;- adpp %&gt;% filter(PPSPEC == \"Urine\", AVISIT == \"CYCLE 1 DAY 1\")\n\n\n\n\n\nCode# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_rows_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ARMCD\"),\n    label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_label = \"PK Parameter\",\n    child_labels = \"hidden\"\n  ) %&gt;%\n  analyze_vars_in_cols(\n    vars = \"AVAL\",\n    .stats = c(\n      \"n\", \"mean\", \"sd\", \"cv\",\n      \"geom_mean\", \"geom_cv\", \"median\",\n      \"min\", \"max\"\n    ),\n    .labels = c(\n      n = \"n\",\n      mean = \"Mean\",\n      sd = \"SD\",\n      cv = \"CV (%)\",\n      geom_mean = \"Geometric Mean\",\n      geom_cv = \"CV % Geometric Mean\",\n      median = \"Median\",\n      min = \"Minimum\",\n      max = \"Maximum\"\n    ),\n    .formats = c(\n      n = \"xx.\",\n      mean = sprintf_format(\"%.3e\"),\n      sd = sprintf_format(\"%.3e\"),\n      cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      geom_mean = sprintf_format(\"%.3e\"),\n      geom_cv = \"xx.x\",\n      min = sprintf_format(\"%.3e\"),\n      max = sprintf_format(\"%.3e\")\n    )\n  )\n\n\nPlasma Drug X\n\nCodeadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp0$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Arm                                                                                                                         \n  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nARM A                                                                                                                                 \n  Ae (mg)              268   1.551e+00   3.385e-01    21.8      1.513e+00             23.0           1.547e+00   7.021e-01   2.464e+00\n  Fe (%)               268   1.571e+01   3.348e+00    21.3      1.534e+01             22.2           1.577e+01   8.147e+00   2.452e+01\n  CLR (L/hr)           134   4.918e-02   9.611e-03    19.5      4.818e-02             21.0           4.909e-02   2.488e-02   7.511e-02\n  RENALCLD (L/hr/mg)   134   4.873e-03   9.654e-04    19.8      4.772e-03             21.2           4.967e-03   2.385e-03   7.258e-03\nARM C                                                                                                                                 \n  Ae (mg)              264   1.535e+00   2.978e-01    19.4      1.505e+00             20.3           1.547e+00   8.502e-01   2.208e+00\n  Fe (%)               264   1.609e+01   3.103e+00    19.3      1.578e+01             20.2           1.604e+01   8.503e+00   2.443e+01\n  CLR (L/hr)           132   5.024e-02   1.050e-02    20.9      4.913e-02             21.9           4.984e-02   2.505e-02   8.560e-02\n  RENALCLD (L/hr/mg)   132   5.110e-03   9.339e-04    18.3      5.019e-03             19.7           5.151e-03   2.356e-03   7.407e-03\n\n\nPlasma Drug Y\n\nCodeadpp1 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug Y\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp1)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp1$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp1$PPCAT), \"\\nVisit:\", unique(adpp1$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug Y \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Arm                                                                                                                         \n  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nARM C                                                                                                                                 \n  Ae (mg)              264   1.598e+00   3.154e-01    19.7      1.565e+00             21.4           1.603e+00   8.574e-01   2.257e+00\n  Fe (%)               264   1.583e+01   3.077e+00    19.4      1.552e+01             20.2           1.570e+01   8.311e+00   2.378e+01\n  CLR (L/hr)           132   4.966e-02   1.009e-02    20.3      4.857e-02             22.0           4.912e-02   1.839e-02   7.761e-02\n  RENALCLD (L/hr/mg)   132   5.093e-03   1.032e-03    20.3      4.985e-03             21.4           5.017e-03   2.356e-03   7.939e-03\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      \n[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      \n[45] pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt11.html",
+    "href": "tables/pharmacokinetic/pkpt11.html",
+    "title": "PKPT11",
+    "section": "",
+    "text": "Data Setup\nStandard Table – Plasma\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\n# Comparator Dose - A: Drug X\narm_var &lt;- \"TRT01A\"\ncomp_dose &lt;- \"A: Drug X\"\nother_doses &lt;- as.character(unique(adpp[[arm_var]])[unique(adpp[[arm_var]]) != comp_dose])\n\nadpp &lt;- adpp %&gt;%\n  filter(AVISIT == \"CYCLE 1 DAY 1\") %&gt;%\n  mutate(\n    COMP = paste0(TRT01A, \"/\", comp_dose),\n    COMP_AVAL = ifelse(TRT01A == comp_dose, paste0(AVAL, comp_dose), AVAL)\n  )\n\nfor (dose in other_doses) {\n  temp_df &lt;- adpp[adpp[[arm_var]] == comp_dose, ]\n  temp_df$COMP &lt;- paste0(dose, \"/\", comp_dose)\n  adpp &lt;- rbind(adpp, temp_df)\n}\n\n# Plasma Drug X\nadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  var_relabel(COMP = \"Comparison\")\n\n# statistics function\ns_gmr &lt;- function(df,\n                  compare_dose = comp_dose, # comparator, defaults to comp_dose defined above (string)\n                  denom = TRUE, # whether to use comparator as denominator, defaults to TRUE (logical)\n                  arm_var = arm_var) { # arm variable, defaults to arm_var defined above (string)\n  which_num &lt;- !grepl(compare_dose, df[[arm_var]])\n\n  x_num &lt;- as.numeric(df[which_num, ][[\"AVAL\"]])\n  x_num &lt;- x_num[!is.na(x_num)]\n  x_num_no_negative_vals &lt;- x_num\n  x_num_no_negative_vals[x_num_no_negative_vals &lt;= 0] &lt;- NA\n\n  x_denom &lt;- as.numeric(gsub(compare_dose, \"\", df[!which_num, ][[\"AVAL\"]]))\n  x_denom &lt;- x_denom[!is.na(x_denom)]\n  x_denom_no_negative_vals &lt;- x_denom\n  x_denom_no_negative_vals[x_denom_no_negative_vals &lt;= 0] &lt;- NA\n\n  x_num_log &lt;- log(x_num_no_negative_vals)\n  x_denom_log &lt;- log(x_denom_no_negative_vals)\n\n  if (denom) {\n    geom_mean_ratio &lt;- exp(mean(x_num_log, na.rm = FALSE)) / exp(mean(x_denom_log, na.rm = FALSE))\n    geom_mean_ci &lt;- t.test(x_num_log, x_denom_log, conf.level = 0.90)$conf.int\n  } else {\n    geom_mean_ratio &lt;- exp(mean(x_denom_log, na.rm = FALSE)) / exp(mean(x_num_log, na.rm = FALSE))\n    geom_mean_ci &lt;- t.test(x_denom_log, x_num_log, conf.level = 0.90)$conf.int\n  }\n\n  list(\n    n = nrow(df),\n    geom_mean_ratio = geom_mean_ratio,\n    gmr_ci_lwr = exp(geom_mean_ci[1]),\n    gmr_ci_upr = exp(geom_mean_ci[2])\n  )\n}\n\nafun_pk_gmr &lt;- function(.formats = list(\n                          n = \"xx.\",\n                          geom_mean_ratio = sprintf_format(\"%.3e\"),\n                          gmr_ci_lwr = sprintf_format(\"%.3e\"),\n                          gmr_ci_upr = sprintf_format(\"%.3e\")\n                        ),\n                        compare_dose = comp_dose,\n                        denom = TRUE) {\n  checkmate::assert_list(.formats)\n  checkmate::assert_subset(names(.formats), c(\"n\", \"geom_mean_ratio\", \"gmr_ci_lwr\", \"gmr_ci_upr\"))\n\n  afun_lst &lt;- Map(\n    function(stat, fmt, compare_dose, denom, arm_var) {\n      function(df, .spl_context) {\n        x_stat &lt;- s_gmr(df, compare_dose = compare_dose, denom = denom, arm_var = arm_var)[[stat]]\n        rcell(x_stat, format = fmt, label = tail(.spl_context$value, 1))\n      }\n    },\n    stat = names(.formats),\n    fmt = .formats,\n    compare_dose = compare_dose,\n    denom = denom,\n    arm_var = arm_var\n  )\n\n  afun_lst\n}\n\n\n\n\n\nCode# create layout\nlyt &lt;- basic_table() %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_fun = keep_split_levels(c(\"AUCinf obs (day*ug/mL)\", \"Cmax (ug/mL)\")),\n    split_label = \"PK Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"COMP\",\n    split_fun = remove_split_levels(paste0(comp_dose, \"/\", comp_dose)),\n    indent_mod = 11L,\n    child_labels = \"hidden\"\n  ) %&gt;%\n  split_cols_by_multivar(\n    vars = rep(\"AVAL\", 4),\n    varlabels = c(\n      \"n\",\n      \"Geometric Mean Ratio\",\n      \"90% CI Lower Bound\",\n      \"90% CI Upper Bound\"\n    )\n  ) %&gt;%\n  analyze_colvars(\n    afun = afun_pk_gmr(),\n    extra_args = list(\n      compare_dose = comp_dose,\n      denom = TRUE,\n      arm_var = arm_var\n    )\n  ) %&gt;%\n  append_varlabels(adpp0, \"COMP\", 12L)\n\nresult &lt;- build_table(lyt, df = adpp0)\n\nmain_title(result) &lt;- paste0(\n  \"Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX Following \",\n  unique(adpp0$REGIMEN), \"\\nof \", comp_dose, \" in Comparison with \",\n  paste(other_doses, collapse = \" & \"), \", PK Population\"\n)\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT))\n\nresult\n\nEstimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX Following BID\nof A: Drug X in Comparison with C: Combination, PK Population\nAnalyte: Plasma Drug X\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nPK Parameter                                                                                                           \n                        Comparison                  n    Geometric Mean Ratio   90% CI Lower Bound   90% CI Upper Bound\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAUCinf obs (day*ug/mL)                                                                                                 \n                        C: Combination/A: Drug X   266        9.615e-01             9.247e-01            9.998e-01     \nCmax (ug/mL)                                                                                                           \n                        C: Combination/A: Drug X   266        9.974e-01             9.583e-01            1.038e+00     \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      \n[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      \n[45] pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/concomitant-medications/cmt01b.html",
+    "href": "tables/concomitant-medications/cmt01b.html",
+    "title": "CMT01B",
+    "section": "",
+    "text": "Data Setup\nStandard Table with  &gt; 1 ATC Class Level\nTable Changing  Class Levels\nTable with Classes  Sorted by Frequency\nTable with Total Number of  Treatments per Medication  Class Suppressed\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nadcm$CMSEQ &lt;- as.factor(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\n# adsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\n# adcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\n# Keep only safety-evaluable patients and concomitant medications\nadsl &lt;- adsl %&gt;%\n  filter(SAFFL == \"Y\")\n\nadcm &lt;- adcm %&gt;%\n  filter(SAFFL == \"Y\" & ATIREL == \"CONCOMITANT\")\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC1\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC1)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC3\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC3)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC4\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC4)\n  ) %&gt;%\n  append_topleft(\"        Other Treatment\") %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC1\", \"*\", \"ATC2\", \"*\", \"ATC3\", \"*\", \"ATC4\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 1 Text                                                                                         \n  ATC Level 2 Text                                                                                       \n    ATC Level 3 Text                                                                                     \n      ATC Level 4 Text                                          A: Drug X    B: Placebo    C: Combination\n        Other Treatment                                          (N=134)       (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment           117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                         415           414            460      \nATCCLAS1 A                                                                                               \n  ATCCLAS2 A                                                                                             \n    ATCCLAS3 A                                                                                           \n      ATCCLAS4 A                                                                                         \n        Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n        Total number of treatments                                 134           137            143      \n        medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n        medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS1 A p2                                                                                            \n  ATCCLAS2 A p2                                                                                          \n    ATCCLAS3 A p2                                                                                        \n      ATCCLAS4 A p2                                                                                      \n        Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n        Total number of treatments                                 58            66              64      \n        medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS1 B                                                                                               \n  ATCCLAS2 B                                                                                             \n    ATCCLAS3 B                                                                                           \n      ATCCLAS4 B                                                                                         \n        Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n        Total number of treatments                                 141           137            162      \n        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n        medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS1 B p2                                                                                            \n  ATCCLAS2 B p2                                                                                          \n    ATCCLAS3 B p2                                                                                        \n      ATCCLAS4 B p2                                                                                      \n        Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n        Total number of treatments                                 75            82              83      \n        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS1 B p3                                                                                            \n  ATCCLAS2 B p3                                                                                          \n    ATCCLAS3 B p3                                                                                        \n      ATCCLAS4 B p3                                                                                      \n        Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n        Total number of treatments                                 75            82              83      \n        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS1 C                                                                                               \n  ATCCLAS2 C                                                                                             \n    ATCCLAS3 C                                                                                           \n      ATCCLAS4 C                                                                                         \n        Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n        Total number of treatments                                 140           140            155      \n        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n        medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS1 C p2                                                                                            \n  ATCCLAS2 C p2                                                                                          \n    ATCCLAS3 C p2                                                                                        \n      ATCCLAS4 C p2                                                                                      \n        Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n        Total number of treatments                                 140           140            155      \n        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n        medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS1 C p3                                                                                            \n  ATCCLAS2 C p3                                                                                          \n    ATCCLAS3 C p3                                                                                        \n      ATCCLAS4 C p3                                                                                      \n        Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n        Total number of treatments                                 69            73              80      \n        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC3\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC3)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_topleft(\"    Other Treatment\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC3\", \"*\", \"ATC2\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 3 Text                                                                                     \n  ATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination\n    Other Treatment                                          (N=134)       (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment       117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                     415           414            460      \nATCCLAS3 A                                                                                           \n  ATCCLAS2 A                                                                                         \n    Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n    Total number of treatments                                 134           137            143      \n    medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS3 A p2                                                                                        \n  ATCCLAS2 A p2                                                                                      \n    Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n    Total number of treatments                                 58            66              64      \n    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS3 B                                                                                           \n  ATCCLAS2 B                                                                                         \n    Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n    Total number of treatments                                 141           137            162      \n    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n    medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS3 B p2                                                                                        \n  ATCCLAS2 B p2                                                                                      \n    Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n    Total number of treatments                                 75            82              83      \n    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS3 B p3                                                                                        \n  ATCCLAS2 B p3                                                                                      \n    Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n    Total number of treatments                                 75            82              83      \n    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS3 C                                                                                           \n  ATCCLAS2 C                                                                                         \n    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n    Total number of treatments                                 140           140            155      \n    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS3 C p2                                                                                        \n  ATCCLAS2 C p2                                                                                      \n    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n    Total number of treatments                                 140           140            155      \n    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS3 C p3                                                                                        \n  ATCCLAS2 C p3                                                                                      \n    Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n    Total number of treatments                                 69            73              80      \n    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n\n\n\n\n\nCode# In progress\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\n    \"ATC1\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC1)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  split_rows_by(\n    \"ATC3\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC3)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC4\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC4)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_topleft(\"        Other Treatment\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC1\", \"*\", \"ATC2\", \"*\", \"ATC3\", \"*\", \"ATC4\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 1 Text                                                                                       \n  ATC Level 2 Text                                                                                     \n    ATC Level 3 Text                                                                                   \n      ATC Level 4 Text                                         A: Drug X    B: Placebo   C: Combination\n        Other Treatment                                         (N=134)      (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————————\nATCCLAS1 A                                                                                             \n  ATCCLAS2 A                                                                                           \n    ATCCLAS3 A                                                                                         \n      Total number of patients with at least one treatment     75 (56.0%)   79 (59.0%)     81 (61.4%)  \n      Total number of treatments                                  134          137            143      \n      ATCCLAS4 A                                                                                       \n        Total number of patients with at least one treatment   75 (56.0%)   79 (59.0%)     81 (61.4%)  \n        medname A_2/3                                          53 (39.6%)   50 (37.3%)     56 (42.4%)  \n        medname A_3/3                                          45 (33.6%)   54 (40.3%)     48 (36.4%)  \nATCCLAS1 A p2                                                                                          \n  ATCCLAS2 A p2                                                                                        \n    ATCCLAS3 A p2                                                                                      \n      Total number of patients with at least one treatment     45 (33.6%)   54 (40.3%)     48 (36.4%)  \n      Total number of treatments                                   58           66             64      \n      ATCCLAS4 A p2                                                                                    \n        Total number of patients with at least one treatment   45 (33.6%)   54 (40.3%)     48 (36.4%)  \n        medname A_3/3                                          45 (33.6%)   54 (40.3%)     48 (36.4%)  \nATCCLAS1 B                                                                                             \n  ATCCLAS2 B                                                                                           \n    ATCCLAS3 B                                                                                         \n      Total number of patients with at least one treatment     83 (61.9%)   74 (55.2%)     88 (66.7%)  \n      Total number of treatments                                  141          137            162      \n      ATCCLAS4 B                                                                                       \n        Total number of patients with at least one treatment   83 (61.9%)   74 (55.2%)     88 (66.7%)  \n        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  \n        medname B_4/4                                          50 (37.3%)   45 (33.6%)     55 (41.7%)  \nATCCLAS1 B p2                                                                                          \n  ATCCLAS2 B p2                                                                                        \n    ATCCLAS3 B p2                                                                                      \n      Total number of patients with at least one treatment     52 (38.8%)   57 (42.5%)     59 (44.7%)  \n      Total number of treatments                                   75           82             83      \n      ATCCLAS4 B p2                                                                                    \n        Total number of patients with at least one treatment   52 (38.8%)   57 (42.5%)     59 (44.7%)  \n        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  \nATCCLAS1 B p3                                                                                          \n  ATCCLAS2 B p3                                                                                        \n    ATCCLAS3 B p3                                                                                      \n      Total number of patients with at least one treatment     52 (38.8%)   57 (42.5%)     59 (44.7%)  \n      Total number of treatments                                   75           82             83      \n      ATCCLAS4 B p3                                                                                    \n        Total number of patients with at least one treatment   52 (38.8%)   57 (42.5%)     59 (44.7%)  \n        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  \nATCCLAS1 C                                                                                             \n  ATCCLAS2 C                                                                                           \n    ATCCLAS3 C                                                                                         \n      Total number of patients with at least one treatment     82 (61.2%)   84 (62.7%)     89 (67.4%)  \n      Total number of treatments                                  140          140            155      \n      ATCCLAS4 C                                                                                       \n        Total number of patients with at least one treatment   82 (61.2%)   84 (62.7%)     89 (67.4%)  \n        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  \n        medname C_1/2                                          51 (38.1%)   50 (37.3%)     56 (42.4%)  \nATCCLAS1 C p2                                                                                          \n  ATCCLAS2 C p2                                                                                        \n    ATCCLAS3 C p2                                                                                      \n      Total number of patients with at least one treatment     82 (61.2%)   84 (62.7%)     89 (67.4%)  \n      Total number of treatments                                  140          140            155      \n      ATCCLAS4 C p2                                                                                    \n        Total number of patients with at least one treatment   82 (61.2%)   84 (62.7%)     89 (67.4%)  \n        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  \n        medname C_1/2                                          51 (38.1%)   50 (37.3%)     56 (42.4%)  \nATCCLAS1 C p3                                                                                          \n  ATCCLAS2 C p3                                                                                        \n    ATCCLAS3 C p3                                                                                      \n      Total number of patients with at least one treatment     52 (38.8%)   58 (43.3%)     60 (45.5%)  \n      Total number of treatments                                   69           73             80      \n      ATCCLAS4 C p3                                                                                    \n        Total number of patients with at least one treatment   52 (38.8%)   58 (43.3%)     60 (45.5%)  \n        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nadcm$CMSEQ &lt;- as.integer(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\n# adsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\n# adcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\nadcm_keys &lt;- c(\"STUDYID\", \"USUBJID\", \"ASTDTM\", \"CMSEQ\", \"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = '\n                  ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n                  ADSL &lt;- df_explicit_na(ADSL)\n                  '),\n    cdisc_dataset(\"ADCM\", adcm,\n      code = '\n      ADCM &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)\n      ADCM &lt;- df_explicit_na(ADCM)\n      ',\n      keys = adcm_keys\n    )\n  ),\n  modules = modules(\n    tm_t_mult_events(\n      label = \"Concomitant Medications by Medication Class and Preferred Name\",\n      dataname = \"ADCM\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      seq_var = choices_selected(\"CMSEQ\", selected = \"CMSEQ\", fixed = TRUE),\n      hlt = choices_selected(\n        choices = variable_choices(adcm, c(\"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")),\n        selected = c(\"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")\n      ),\n      llt = choices_selected(\n        choices = variable_choices(adcm, c(\"CMDECOD\")),\n        selected = c(\"CMDECOD\")\n      ),\n      add_total = FALSE,\n      event_type = \"treatment\"\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\"),\n    ADCM = list(ATIREL = \"CONCOMITANT\")\n  )\n)\n\n[INFO] 2023-09-25 11:09:09.3393 pid:8918 token:[] teal.modules.clinical Initializing tm_t_mult_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/concomitant-medications/cmt01.html",
+    "href": "tables/concomitant-medications/cmt01.html",
+    "title": "CMT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Showing Medications Prior  to the Start of the Study\nTable Sorted by Total Column Showing  Additional “All Patients” Column\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\n# The following tables require ADCM data structure that follows the legacy concomitant medication coding. WHO coding is not used.\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\n# Below step is to set up example data based on legacy standard.\nadcm &lt;- adcm %&gt;%\n  select(-starts_with(\"ATC\")) %&gt;%\n  unique()\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\nadcm_con &lt;- adcm %&gt;%\n  filter(ATIREL == \"CONCOMITANT\")\n\nadcm_prior &lt;- adcm %&gt;%\n  filter(ATIREL == \"PRIOR\")\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\"CMCLAS\",\n    split_fun = split_fun,\n    child_labels = \"visible\",\n    nested = FALSE,\n    indent_mod = 1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm_con$CMCLAS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm_con, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm_con,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"CMCLAS\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedication Class                                            A: Drug X    B: Placebo    C: Combination\n  Standardized Medication Name                               (N=134)       (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment       117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                     415           414            460      \n  medcl A                                                                                            \n    Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n    Total number of treatments                                 134           137            143      \n    medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \n  medcl B                                                                                            \n    Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n    Total number of treatments                                 141           137            162      \n    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n    medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \n  medcl C                                                                                            \n    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n    Total number of treatments                                 140           140            155      \n    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\"CMCLAS\",\n    split_fun = split_fun,\n    child_labels = \"visible\",\n    nested = FALSE,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm_con$CMCLAS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm_prior, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm_prior,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"CMCLAS\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedication Class                                         A: Drug X    B: Placebo   C: Combination\n  Standardized Medication Name                            (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     89 (66.4%)   95 (70.9%)    106 (80.3%)  \nTotal number of treatments                                  194          208            243      \nmedcl A                                                                                          \n  Total number of patients with at least one treatment   54 (40.3%)   49 (36.6%)     69 (52.3%)  \n  Total number of treatments                                 71           70             99      \n  medname A_1/3                                          54 (40.3%)   49 (36.6%)     69 (52.3%)  \nmedcl B                                                                                          \n  Total number of patients with at least one treatment   76 (56.7%)   80 (59.7%)     81 (61.4%)  \n  Total number of treatments                                123          138            144      \n  medname B_2/4                                          52 (38.8%)   55 (41.0%)     56 (42.4%)  \n  medname B_3/4                                          47 (35.1%)   47 (35.1%)     52 (39.4%)  \n\n\nTable with Subtotal Per  Medication Class Suppressed\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\"CMCLAS\",\n    split_fun = split_fun, child_labels = \"visible\",\n    nested = FALSE,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm_con$CMCLAS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .labels = c(unique = \"Total number of patients with at least one treatment\"),\n    .stats = \"unique\"\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm_con, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm_con,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"CMCLAS\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nMedication Class                                          A: Drug X    B: Placebo    C: Combination\n  Standardized Medication Name                             (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                   415           414            460      \nmedcl A                                                                                            \n  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nmedcl B                                                                                            \n  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nmedcl C                                                                                            \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      \"Total number of patients with at least one treatment (%)\",\n      \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"CMCLAS\",\n    split_fun = split_fun,\n    child_labels = \"visible\",\n    nested = FALSE,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm_con$CMCLAS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      \"Total number of patients with at least one treatment (%)\",\n      \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm_con, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adcm_con,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = c(\"CMCLAS\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"CMCLAS\"),\n    scorefun = cont_n_allcols,\n    decreasing = TRUE\n  )\n\nresult\n\nMedication Class                                              A: Drug X    B: Placebo    C: Combination   All Patients\n  Standardized Medication Name                                 (N=134)       (N=134)        (N=132)         (N=400)   \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment (%)     117 (87.3%)   116 (86.6%)    116 (87.9%)     349 (87.2%) \nTotal number of treatments                                       415           414            460             1289    \nmedcl C                                                                                                               \n  Total number of patients with at least one treatment (%)   82 (61.2%)    84 (62.7%)      89 (67.4%)     255 (63.7%) \n  Total number of treatments                                     140           140            155             435     \n  medname C_2/2                                              52 (38.8%)    58 (43.3%)      60 (45.5%)     170 (42.5%) \n  medname C_1/2                                              51 (38.1%)    50 (37.3%)      56 (42.4%)     157 (39.2%) \nmedcl B                                                                                                               \n  Total number of patients with at least one treatment (%)   83 (61.9%)    74 (55.2%)      88 (66.7%)     245 (61.3%) \n  Total number of treatments                                     141           137            162             440     \n  medname B_1/4                                              52 (38.8%)    57 (42.5%)      59 (44.7%)     168 (42.0%) \n  medname B_4/4                                              50 (37.3%)    45 (33.6%)      55 (41.7%)     150 (37.5%) \nmedcl A                                                                                                               \n  Total number of patients with at least one treatment (%)   75 (56.0%)    79 (59.0%)      81 (61.4%)     235 (58.8%) \n  Total number of treatments                                     134           137            143             414     \n  medname A_2/3                                              53 (39.6%)    50 (37.3%)      56 (42.4%)     159 (39.8%) \n  medname A_3/3                                              45 (33.6%)    54 (40.3%)      48 (36.4%)     147 (36.8%) \n\n\n\n\nHere, adcm is processed to keep only one path per treatment.\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\nadcm &lt;- adcm %&gt;%\n  group_by(STUDYID, USUBJID, CMDECOD) %&gt;%\n  slice(1) %&gt;%\n  ungroup()\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'\n    ),\n    cdisc_dataset(\n      \"ADCM\",\n      adcm,\n      code = 'ADCM &lt;- df_explicit_na(\n      synthetic_cdisc_dataset(\"latest\", \"adcm\")\n      ) %&gt;%\n        group_by(STUDYID, USUBJID, CMDECOD) %&gt;%\n        slice(1) %&gt;%\n        ungroup',\n      keys = c(\"STUDYID\", \"USUBJID\", \"ASTDTM\", \"CMSEQ\", \"CMDECOD\")\n    )\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Concomitant Medication Table\",\n      dataname = \"ADCM\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adcm, \"CMDECOD\"),\n        selected = \"CMDECOD\"\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adcm, \"CMCLAS\"),\n        selected = c(\"CMCLAS\")\n      ),\n      add_total = TRUE,\n      event_type = \"treatment\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:07:53.4451 pid:8721 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/vital-signs/vst01.html",
+    "href": "tables/vital-signs/vst01.html",
+    "title": "VST01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadvs &lt;- df_explicit_na(advs)\n\nadvs_label &lt;- var_labels(advs)\n\nadvs &lt;- advs %&gt;%\n  filter(\n    PARAMCD == \"DIABP\",\n    PARAM == \"Diastolic Blood Pressure\"\n  ) %&gt;%\n  mutate(\n    PARAMCD = droplevels(PARAMCD),\n    PARAM = droplevels(PARAM)\n  )\n\n# post-baseline\nadvs_pb &lt;- advs %&gt;%\n  filter(ABLFL != \"Y\", ABLFL2 != \"Y\")\n\nadvs_pb_max &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(desc(AVAL)) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Maximum\")\n\nadvs_pb_min &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(AVAL) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Minimum\")\n\nadvs_pb_last &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(desc(AVISITN)) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Last\")\n\n# Please note that for real data, per ADaM Spec 1.1, the advs_f can be obtained by filtering on PARAMCD, then\n# ANL01FL == 'Y' or AVISIT in c('POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST')\n\nadvs_f &lt;- rbind(\n  advs,\n  advs_pb_last,\n  advs_pb_min,\n  advs_pb_max\n)\n\nadvs_f &lt;- advs_f %&gt;%\n  mutate(AVISIT = droplevels(AVISIT))\n\nvar_labels(advs_f) &lt;- advs_label\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nafun &lt;- function(x, .var, .spl_context, ...) {\n  n_fun &lt;- sum(!is.na(x), na.rm = TRUE)\n  if (n_fun == 0) {\n    mean_sd_fun &lt;- c(NA, NA)\n    median_fun &lt;- NA\n    min_max_fun &lt;- c(NA, NA)\n  } else {\n    mean_sd_fun &lt;- c(mean(x, na.rm = TRUE), sd(x, na.rm = TRUE))\n    median_fun &lt;- median(x, na.rm = TRUE)\n    min_max_fun &lt;- c(min(x), max(x))\n  }\n  is_chg &lt;- .var == \"CHG\"\n  is_baseline &lt;- .spl_context$value[which(.spl_context$split == \"AVISIT\")] == \"BASELINE\"\n  if (is_baseline && is_chg) n_fun &lt;- mean_sd_fun &lt;- median_fun &lt;- min_max_fun &lt;- NULL\n\n  in_rows(\n    \"n\" = n_fun,\n    \"Mean (SD)\" = mean_sd_fun,\n    \"Median\" = median_fun,\n    \"Min - Max\" = min_max_fun,\n    .formats = list(\"n\" = \"xx\", \"Mean (SD)\" = \"xx.xx (xx.xx)\", \"Median\" = \"xx.xx\", \"Min - Max\" = \"xx.xx - xx.xx\"),\n    .format_na_strs = list(\"n\" = \"NE\", \"Mean (SD)\" = \"NE (NE)\", \"Median\" = \"NE\", \"Min - Max\" = \"NE - NE\")\n  )\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = \"\\n\\nAnalysis Visit\") %&gt;%\n  split_cols_by_multivar(\n    vars = c(\"AVAL\", \"CHG\"),\n    varlabels = c(\"Value at Visit\", \"Change from\\nBaseline\")\n  ) %&gt;%\n  analyze_colvars(afun = afun)\n\nresult &lt;- build_table(lyt = lyt, df = advs_f, alt_counts_df = adsl)\nresult\n\n                                   A: Drug X                        B: Placebo                      C: Combination         \n                                          Change from                       Change from                       Change from  \nAnalysis Visit          Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   \n                           (N=134)          (N=134)          (N=134)          (N=134)          (N=132)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nSCREENING                                                                                                                  \n  n                          134               0               134               0               132               0       \n  Mean (SD)             99.92 (17.99)       NE (NE)       101.88 (21.07)      NE (NE)       100.48 (19.07)      NE (NE)    \n  Median                    99.26              NE             100.22             NE             99.10              NE      \n  Min - Max             54.22 - 152.98      NE - NE       48.15 - 148.03      NE - NE       42.22 - 149.95      NE - NE    \nBASELINE                                                                                                                   \n  n                          134                               134                               132                       \n  Mean (SD)             96.50 (19.90)                     101.10 (19.87)                    102.77 (19.48)                 \n  Median                    96.05                             100.45                            102.01                     \n  Min - Max             44.28 - 136.59                    29.21 - 143.77                    49.37 - 153.50                 \nWEEK 1 DAY 8                                                                                                               \n  n                          134              134              134              134              132              132      \n  Mean (SD)             100.65 (18.79)    4.14 (26.93)    99.19 (19.36)    -1.92 (27.37)    97.14 (19.72)    -5.63 (25.95) \n  Median                    100.22            1.52            99.37            -2.79            94.19            -5.57     \n  Min - Max             57.60 - 147.46   -50.92 - 74.84   59.28 - 141.21   -64.50 - 70.93   50.98 - 142.47   -55.15 - 56.11\nWEEK 2 DAY 15                                                                                                              \n  n                          134              134              134              134              132              132      \n  Mean (SD)             102.09 (19.62)    5.58 (29.38)    99.29 (21.11)    -1.81 (31.11)    99.95 (20.85)    -2.81 (29.10) \n  Median                    103.59            7.82            100.57           -1.77            102.52           -5.68     \n  Min - Max             54.73 - 150.85   -59.71 - 98.08   51.60 - 145.28   -71.00 - 92.43   37.06 - 138.92   -73.10 - 76.80\nWEEK 3 DAY 22                                                                                                              \n  n                          134              134              134              134              132              132      \n  Mean (SD)             101.78 (19.54)    5.28 (27.16)    97.73 (19.85)    -3.37 (27.76)    99.86 (19.15)    -2.91 (27.25) \n  Median                    100.39            6.53            98.83            -5.79            100.06           -1.54     \n  Min - Max             47.68 - 162.22   -64.46 - 76.64   36.25 - 142.78   -70.23 - 84.74   53.80 - 146.37   -74.30 - 67.46\nWEEK 4 DAY 29                                                                                                              \n  n                          134              134              134              134              132              132      \n  Mean (SD)             100.18 (20.18)    3.68 (27.21)    99.06 (17.75)    -2.04 (26.59)    99.27 (20.12)    -3.50 (27.62) \n  Median                    98.17             3.00            97.98            -1.89            99.61            -0.46     \n  Min - Max             48.52 - 153.41   -77.30 - 61.90   56.78 - 142.45   -82.96 - 89.87   46.87 - 146.12   -88.68 - 70.90\nWEEK 5 DAY 36                                                                                                              \n  n                          134              134              134              134              132              132      \n  Mean (SD)             101.42 (18.83)    4.92 (28.02)    95.92 (19.90)    -5.19 (29.34)    97.73 (18.92)    -5.04 (26.64) \n  Median                    98.56             3.93            94.30            -7.18            98.09            -5.62     \n  Min - Max             62.66 - 155.52   -63.05 - 78.66   51.06 - 151.52   -78.07 - 72.91   51.48 - 157.27   -76.13 - 86.42\nPost-Baseline Last                                                                                                         \n  n                          134              134              134              134              132              132      \n  Mean (SD)             101.42 (18.83)    4.92 (28.02)    95.92 (19.90)    -5.19 (29.34)    97.73 (18.92)    -5.04 (26.64) \n  Median                    98.56             3.93            94.30            -7.18            98.09            -5.62     \n  Min - Max             62.66 - 155.52   -63.05 - 78.66   51.06 - 151.52   -78.07 - 72.91   51.48 - 157.27   -76.13 - 86.42\nPost-Baseline Minimum                                                                                                      \n  n                          134              134              134              134              132              132      \n  Mean (SD)             78.98 (11.94)    -17.52 (23.92)   75.77 (13.25)    -25.33 (25.39)   76.35 (13.13)    -26.41 (22.78)\n  Median                    80.14            -13.96           75.71            -26.70           76.26            -27.17    \n  Min - Max             47.68 - 110.54   -77.30 - 33.00   36.25 - 113.53   -82.96 - 69.23   37.06 - 112.35   -88.68 - 34.24\nPost-Baseline Maximum                                                                                                      \n  n                          134              134              134              134              132              132      \n  Mean (SD)             125.08 (12.28)   28.57 (23.20)    121.33 (12.01)   20.23 (23.64)    121.42 (12.09)   18.65 (22.74) \n  Median                    124.20           29.14            120.80           18.74            122.55           16.93     \n  Min - Max             94.06 - 162.22   -21.49 - 98.08   94.43 - 151.52   -34.95 - 92.43   79.39 - 157.27   -43.32 - 86.42\n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\nadvs_label &lt;- var_labels(advs)\n\n# post-baseline\nadvs_pb &lt;- advs %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    ABLFL2 != \"Y\"\n  )\n\nadvs_pb_max &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(desc(AVAL)) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Maximum\")\n\nadvs_pb_min &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(AVAL) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Minimum\")\n\nadvs_pb_last &lt;- advs_pb %&gt;%\n  group_by(PARAM, USUBJID) %&gt;%\n  arrange(desc(AVISITN)) %&gt;%\n  slice(1) %&gt;%\n  ungroup() %&gt;%\n  mutate(AVISIT = \"Post-Baseline Last\")\n\nadvs_f &lt;- rbind(\n  advs,\n  advs_pb_last,\n  advs_pb_min,\n  advs_pb_max\n)\n\nadvs_f &lt;- advs_f %&gt;%\n  mutate(AVISIT = droplevels(AVISIT))\n\nvar_labels(advs_f) &lt;- advs_label\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'\n    ),\n    cdisc_dataset(\"ADVS\",\n      advs_f,\n      code = 'ADVS &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\n                  ADVS_label &lt;- var_labels(ADVS)\n\n                  # post-baseline\n                  ADVS_pb &lt;- ADVS %&gt;%\n                    filter(\n                      ABLFL != \"Y\",\n                      ABLFL2 != \"Y\"\n                    )\n\n                  ADVS_pb_max &lt;- ADVS_pb %&gt;%\n                    group_by(PARAM, USUBJID) %&gt;%\n                    arrange(desc(AVAL)) %&gt;%\n                    slice(1) %&gt;%\n                    ungroup() %&gt;%\n                    mutate(AVISIT = \"Post-Baseline Maximum\")\n\n                  ADVS_pb_min &lt;- ADVS_pb %&gt;%\n                    group_by(PARAM, USUBJID) %&gt;%\n                    arrange(AVAL) %&gt;%\n                    slice(1) %&gt;%\n                    ungroup() %&gt;%\n                    mutate(AVISIT = \"Post-Baseline Minimum\")\n\n                  ADVS_pb_last &lt;- ADVS_pb %&gt;%\n                    group_by(PARAM, USUBJID) %&gt;%\n                    arrange(desc(AVISITN)) %&gt;%\n                    slice(1) %&gt;%\n                    ungroup() %&gt;%\n                    mutate(AVISIT = \"Post-Baseline Last\")\n\n                  ADVS_f &lt;- rbind(\n                    ADVS,\n                    ADVS_pb_last,\n                    ADVS_pb_min,\n                    ADVS_pb_max\n                  )\n\n                  ADVS &lt;- ADVS_f %&gt;%\n                    mutate(AVISIT = droplevels(AVISIT))\n                  var_labels(ADVS) &lt;- ADVS_label'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Vital Sign Results and Change from Baseline by Visit\",\n      dataname = \"ADVS\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(advs, c(\"PARAM\", \"AVISIT\")),\n        selected = c(\"AVISIT\", \"PARAM\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(advs, c(\"AVAL\", \"CHG\")),\n        selected = c(\"AVAL\", \"CHG\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(advs, \"PARAMCD\", \"PARAM\"),\n        selected = \"DIABP\"\n      ),\n      parallel_vars = TRUE\n    )\n  ),\n  filter = list(ADVS = list(AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:06:29.2573 pid:8525 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disclosures/eudrat02.html",
+    "href": "tables/disclosures/eudrat02.html",
+    "title": "EUDRAT02",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\nFor illustrative purposes, the adae data is filtered by arm A: Drug X here.\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadae &lt;- df_explicit_na(adae)\n\nadae_serious &lt;- adae %&gt;% filter(AESER == \"Y\", SAFFL == \"Y\")\nadae_serious_arm &lt;- adae_serious %&gt;% filter(ARM == \"A: Drug X\")\n\nfilters_list &lt;- list(\n  related = with_label(c(AEREL = \"Y\"), \"Events (Related)\"),\n  fatal = with_label(c(AESDTH = \"Y\"), \"Events (Fatal)\"),\n  fatal_related = with_label(c(AEREL = \"Y\", AESDTH = \"Y\"), \"Events (Fatal & Related)\")\n)\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  summarize_patients_events_in_cols(\n    filters_list = filters_list,\n    empty_stats = c(\"all\", \"related\", \"fatal\", \"fatal_related\"),\n    custom_label = \"Total number of patients with at least one serious adverse event\"\n  ) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    nested = FALSE,\n    split_fun = split_fun,\n    indent_mod = -1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_serious_arm$AEBODSYS)\n  ) %&gt;%\n  split_rows_by(\"AEDECOD\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_serious_arm$AEDECOD)\n  ) %&gt;%\n  summarize_patients_events_in_cols(\n    filters_list = filters_list,\n    col_split = FALSE\n  )\n\nresult &lt;- build_table(lyt, adae_serious_arm)\nresult\n\nBody System or Organ Class                                                                                                                                     \n  Dictionary-Derived Term                                          Patients (All)   Events (All)   Events (Related)   Events (Fatal)   Events (Fatal & Related)\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one serious adverse event        104                                                                                    \ncl A.1                                                                                                                                                         \n  dcd A.1.1.1.2                                                          48              68               0                 0                     0            \ncl B.1                                                                                                                                                         \n  dcd B.1.1.1.1                                                          47              56               56                56                    56           \ncl B.2                                                                                                                                                         \n  dcd B.2.2.3.1                                                          48              64               0                 0                     0            \ncl D.1                                                                                                                                                         \n  dcd D.1.1.1.1                                                          50              61               61                61                    61           \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/aovt03.html",
+    "href": "tables/efficacy/aovt03.html",
+    "title": "AOVT03",
+    "section": "",
+    "text": "This example will focus on data from multiple visits and take the interaction between visits and arms into consideration.\n\n\nData Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\nadqs_in &lt;- adqs %&gt;%\n  filter(AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 5 DAY 36\")) %&gt;%\n  droplevels() %&gt;%\n  filter(PARAM %in% c(\"BFI All Questions\", \"Fatigue Interference\")) %&gt;%\n  mutate(CHG = ifelse(BMEASIFL == \"Y\", CHG, NA)) # only analyze evaluable population\n\n\n\n\n\nCoderesult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels) %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(arm = \"ARMCD\", covariates = c(\"BASE\", \"AVISIT\", \"AVISIT*ARMCD\")),\n    conf_level = 0.95,\n    var_labels = \"WEEK 1 DAY 8\",\n    table_names = \"WEEK 1 DAY 8\",\n    interaction_y = \"WEEK 1 DAY 8\",\n    interaction_item = \"AVISIT\"\n  ) %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(arm = \"ARMCD\", covariates = c(\"BASE\", \"AVISIT\", \"AVISIT*ARMCD\")),\n    conf_level = 0.95,\n    var_labels = \"WEEK 2 DAY 15\",\n    table_names = \"WEEK 2 DAY 15\",\n    interaction_y = \"WEEK 2 DAY 15\",\n    interaction_item = \"AVISIT\"\n  ) %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(arm = \"ARMCD\", covariates = c(\"BASE\", \"AVISIT\", \"AVISIT*ARMCD\")),\n    conf_level = 0.95,\n    var_labels = \"WEEK 5 DAY 36\",\n    table_names = \"WEEK 5 DAY 36\",\n    interaction_y = \"WEEK 5 DAY 36\",\n    interaction_item = \"AVISIT\"\n  ) %&gt;%\n  build_table(adqs_in, alt_counts_df = adsl)\n\nresult\n\n                                    ARM A        ARM B           ARM C    \n                                   (N=134)      (N=134)         (N=132)   \n——————————————————————————————————————————————————————————————————————————\nBFI All Questions                                                         \n  WEEK 1 DAY 8                                                            \n    n                                68           73              62      \n    Adjusted Mean                   4.34         5.96            3.90     \n    Difference in Adjusted Means                 1.62            -0.44    \n      95% CI                                 (-1.75, 4.98)   (-3.94, 3.06)\n      p-value                                   0.3460          0.8059    \n  WEEK 2 DAY 15                                                           \n    n                                68           73              62      \n    Adjusted Mean                   12.99        11.23           9.86     \n    Difference in Adjusted Means                 -1.76           -3.13    \n      95% CI                                 (-5.12, 1.60)   (-6.64, 0.37)\n      p-value                                   0.3048          0.0795    \n  WEEK 5 DAY 36                                                           \n    n                                68           73              62      \n    Adjusted Mean                   23.88        23.08           28.21    \n    Difference in Adjusted Means                 -0.81           4.33     \n      95% CI                                 (-4.17, 2.56)   (0.83, 7.83) \n      p-value                                   0.6383          0.0155    \nFatigue Interference                                                      \n  WEEK 1 DAY 8                                                            \n    n                                68           73              62      \n    Adjusted Mean                   5.97         5.19            5.21     \n    Difference in Adjusted Means                 -0.78           -0.76    \n      95% CI                                 (-4.17, 2.61)   (-4.30, 2.78)\n      p-value                                   0.6522          0.6729    \n  WEEK 2 DAY 15                                                           \n    n                                68           73              62      \n    Adjusted Mean                   11.39        9.42            9.55     \n    Difference in Adjusted Means                 -1.96           -1.84    \n      95% CI                                 (-5.35, 1.43)   (-5.37, 1.70)\n      p-value                                   0.2560          0.3084    \n  WEEK 5 DAY 36                                                           \n    n                                68           73              62      \n    Adjusted Mean                   22.79        25.37           23.43    \n    Difference in Adjusted Means                 2.58            0.64     \n      95% CI                                 (-0.81, 5.97)   (-2.89, 4.18)\n      p-value                                   0.1353          0.7212    \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] sandwich_3.0-2     utf8_1.2.3         generics_0.1.3     tidyr_1.3.0       \n [5] lattice_0.21-8     digest_0.6.33      evaluate_0.21      grid_4.3.1        \n [9] estimability_1.4.1 mvtnorm_1.2-3      fastmap_1.1.1      jsonlite_1.8.7    \n[13] Matrix_1.6-1.1     backports_1.4.1    brio_1.1.3         survival_3.5-7    \n[17] multcomp_1.4-25    purrr_1.0.2        fansi_1.0.4        scales_1.2.1      \n[21] TH.data_1.1-2      codetools_0.2-19   Rdpack_2.5         cli_3.6.1         \n[25] rlang_1.1.1        rbibutils_2.2.15   munsell_0.5.0      splines_4.3.1     \n[29] yaml_2.3.7         tools_4.3.1        checkmate_2.2.0    coda_0.19-4       \n[33] colorspace_2.1-0   ggplot2_3.4.3      broom_1.0.5        vctrs_0.6.3       \n[37] R6_2.5.1           zoo_1.8-12         lifecycle_1.0.3    emmeans_1.8.8     \n[41] htmlwidgets_1.6.2  MASS_7.3-60        pkgconfig_2.0.3    pillar_1.9.0      \n[45] gtable_0.3.4       glue_1.6.2         xfun_0.40          tibble_3.2.1      \n[49] tidyselect_1.2.0   rstudioapi_0.15.0  knitr_1.44         xtable_1.8-4      \n[53] htmltools_0.5.6    rmarkdown_2.25     testthat_3.1.10    compiler_4.3.1    \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/rbmit01.html",
+    "href": "tables/efficacy/rbmit01.html",
+    "title": "RBMIT01",
+    "section": "",
+    "text": "Data Setup\nDraws\nImpute\nAnalyze\nPool\nCreate Output\nReproducibility\n\n\n\nWe use a publicly available example dataset from an antidepressant clinical trial of an active drug versus placebo from the rbmi package. The relevant endpoint is the Hamilton 17-item depression rating scale (HAMD17) which was assessed at baseline and at weeks 1, 2, 4, and 6. Study drug discontinuation occurred in 24% of subjects from the active drug and 26% of subjects from placebo. All data after study drug discontinuation are missing and there is a single additional intermittent missing observation.\n\nCodelibrary(tern.rbmi)\nlibrary(dplyr)\nset.seed(123)\n\ndata &lt;- antidepressant_data\nlevels(data$THERAPY) &lt;- c(\"PLACEBO\", \"DRUG\") # This is important! The order defines the computation order later\n\nmissing_var &lt;- \"CHANGE\"\nvars &lt;- list(\n  id = \"PATIENT\",\n  visit = \"VISIT\",\n  expand_vars = c(\"BASVAL\", \"THERAPY\"),\n  group = \"THERAPY\"\n)\ncovariates &lt;- list(\n  draws = c(\"BASVAL*VISIT\", \"THERAPY*VISIT\"),\n  analyse = c(\"BASVAL\")\n)\n\ndata &lt;- data %&gt;%\n  dplyr::select(PATIENT, THERAPY, VISIT, BASVAL, THERAPY, CHANGE) %&gt;%\n  dplyr::mutate(dplyr::across(.cols = vars$id, ~ as.factor(.x))) %&gt;%\n  dplyr::arrange(dplyr::across(.cols = c(vars$id, vars$visit)))\n\n# Use expand_locf to add rows corresponding to visits with missing outcomes to the dataset\ndata_full &lt;- do.call(\n  expand_locf,\n  args = list(\n    data = data,\n    vars = c(vars$expand_vars, vars$group),\n    group = vars$id,\n    order = c(vars$id, vars$visit)\n  ) %&gt;%\n    append(lapply(data[c(vars$id, vars$visit)], levels))\n)\n\ndata_full &lt;- data_full %&gt;%\n  dplyr::group_by(dplyr::across(vars$id)) %&gt;%\n  dplyr::mutate(!!vars$group := Filter(Negate(is.na), .data[[vars$group]])[1])\n\n# there are duplicates - use first value\ndata_full &lt;- data_full %&gt;%\n  dplyr::group_by(dplyr::across(c(vars$id, vars$group, vars$visit))) %&gt;%\n  dplyr::slice(1) %&gt;%\n  dplyr::ungroup()\n# need to have a single ID column\ndata_full &lt;- data_full %&gt;%\n  tidyr::unite(\"TMP_ID\", dplyr::all_of(vars$id), sep = \"_#_\", remove = FALSE) %&gt;%\n  dplyr::mutate(TMP_ID = as.factor(TMP_ID))\n\n\nCreating Intercurrent Event Data\nSet the imputation strategy to \"MAR\" for each patient with at least one missing observation.\n\nCodedata_ice &lt;- data_full %&gt;%\n  dplyr::arrange(dplyr::across(.cols = c(\"TMP_ID\", vars$visit))) %&gt;%\n  dplyr::filter(is.na(.data[[missing_var]])) %&gt;%\n  dplyr::group_by(TMP_ID) %&gt;%\n  dplyr::slice(1) %&gt;%\n  dplyr::ungroup() %&gt;%\n  dplyr::select(all_of(c(\"TMP_ID\", vars$visit))) %&gt;%\n  dplyr::mutate(strategy = \"MAR\")\n\n\n\n\n\nThe rbmi::draws() function fits the imputation models and stores the corresponding parameter estimates or Bayesian posterior parameter draws. The three main inputs to the rbmi::draws() function are:\n\n\ndata - The primary longitudinal data.frame containing the outcome variable and all covariates.\n\ndata_ice - A data.frame which specifies the first visit affected by an intercurrent event (ICE) and the imputation strategy for handling missing outcome data after the ICE. At most one ICE which is to be imputed by a non-MAR strategy is allowed per subject.\n\nmethod - The statistical method used to fit the imputation models and to create imputed datasets.\n\nDefine Key Variables\nDefine the names of key variables in our dataset and the covariates included in the imputation model using rbmi::set_vars(). Note that the covariates argument can also include interaction terms.\n\nCodedebug_mode &lt;- FALSE\n\ndraws_vars &lt;- rbmi::set_vars(\n  outcome = missing_var,\n  visit = vars$visit,\n  group = vars$group,\n  covariates = covariates$draws\n)\ndraws_vars$subjid &lt;- \"TMP_ID\"\n\n\nDefine which imputation method to use, then create samples for the imputation parameters by running the draws() function.\n\nCodedraws_method &lt;- method_bayes()\n\ndraws_obj &lt;- rbmi::draws(\n  data = data_full,\n  data_ice = data_ice,\n  vars = draws_vars,\n  method = draws_method\n)\n\n\nSAMPLING FOR MODEL 'MMRM' NOW (CHAIN 1).\nChain 1: \nChain 1: Gradient evaluation took 0.000597 seconds\nChain 1: 1000 transitions using 10 leapfrog steps per transition would take 5.97 seconds.\nChain 1: Adjust your expectations accordingly!\nChain 1: \nChain 1: \nChain 1: Iteration:    1 / 1200 [  0%]  (Warmup)\nChain 1: Iteration:  120 / 1200 [ 10%]  (Warmup)\nChain 1: Iteration:  201 / 1200 [ 16%]  (Sampling)\nChain 1: Iteration:  320 / 1200 [ 26%]  (Sampling)\nChain 1: Iteration:  440 / 1200 [ 36%]  (Sampling)\nChain 1: Iteration:  560 / 1200 [ 46%]  (Sampling)\nChain 1: Iteration:  680 / 1200 [ 56%]  (Sampling)\nChain 1: Iteration:  800 / 1200 [ 66%]  (Sampling)\nChain 1: Iteration:  920 / 1200 [ 76%]  (Sampling)\nChain 1: Iteration: 1040 / 1200 [ 86%]  (Sampling)\nChain 1: Iteration: 1160 / 1200 [ 96%]  (Sampling)\nChain 1: Iteration: 1200 / 1200 [100%]  (Sampling)\nChain 1: \nChain 1:  Elapsed Time: 0.893 seconds (Warm-up)\nChain 1:                3.133 seconds (Sampling)\nChain 1:                4.026 seconds (Total)\nChain 1: \n\n\n\n\n\nThe next step is to use the parameters from the imputation model to generate the imputed datasets. This is done via the rbmi::impute() function. The function only has two key inputs: the imputation model output from rbmi::draws() and the reference groups relevant to reference-based imputation methods. It’s usage is thus:\n\nCodeimpute_references &lt;- c(\"DRUG\" = \"PLACEBO\", \"PLACEBO\" = \"PLACEBO\")\n\nimpute_obj &lt;- rbmi::impute(\n  draws_obj,\n  references = impute_references\n)\n\n\n\n\nThe next step is to run the analysis model on each imputed dataset. This is done by defining an analysis function and then calling rbmi::analyse() to apply this function to each imputed dataset.\n\nCode# Define analysis model\nanalyse_fun &lt;- ancova\n\nref_levels &lt;- levels(impute_obj$data$group[[1]])\nnames(ref_levels) &lt;- c(\"ref\", \"alt\")\n\nanalyse_obj &lt;- rbmi::analyse(\n  imputations = impute_obj,\n  fun = analyse_fun,\n  vars = rbmi::set_vars(\n    subjid = \"TMP_ID\",\n    outcome = missing_var,\n    visit = vars$visit,\n    group = vars$group,\n    covariates = covariates$analyse\n  )\n)\n\n\n\n\nThe rbmi::pool() function can be used to summarize the analysis results across multiple imputed datasets to provide an overall statistic with a standard error, confidence intervals and a p-value for the hypothesis test of the null hypothesis that the effect is equal to 0. Using the broom::tidy() function the rbmi final results are reshaped.\n\nCodelibrary(broom)\n\npool_obj &lt;- rbmi::pool(\n  results = analyse_obj,\n  conf.level = 0.95,\n  alternative = c(\"two.sided\", \"less\", \"greater\"),\n  type = c(\"percentile\", \"normal\")\n)\n\ndf &lt;- tidy(pool_obj)\ndf\n\n  group       est    se_est lower_cl_est upper_cl_est   est_contr  se_contr\n1   ref -1.615820 0.4862316    -2.575771   -0.6558685          NA        NA\n2   alt -1.707626 0.4749573    -2.645319   -0.7699335 -0.09180645 0.6826279\n3   ref -4.249254 0.6516319    -5.536213   -2.9622946          NA        NA\n4   alt -2.831077 0.6457793    -4.106986   -1.5551687  1.41817668 0.9189337\n5   ref -6.358552 0.7101739    -7.762347   -4.9547560          NA        NA\n6   alt -4.130754 0.6923008    -5.499118   -2.7623890  2.22779812 0.9955083\n7   ref -7.642160 0.8026102    -9.231000   -6.0533202          NA        NA\n8   alt -4.831049 0.7784757    -6.371584   -3.2905138  2.81111124 1.1270640\n  lower_cl_contr upper_cl_contr    p_value relative_reduc visit conf_level\n1             NA             NA         NA             NA     4       0.95\n2     -1.4394968       1.255884 0.89317724     0.05681725     4       0.95\n3             NA             NA         NA             NA     5       0.95\n4     -0.3969026       3.233256 0.12477649    -0.33374722     5       0.95\n5             NA             NA         NA             NA     6       0.95\n6      0.2600937       4.195503 0.02676669    -0.35036251     6       0.95\n7             NA             NA         NA             NA     7       0.95\n8      0.5799592       5.042263 0.01396370    -0.36784249     7       0.95\n\n\n\n\nFinally, use functions from the rtables and tern packages to generate a nicely formatted rtable object.\n\nCoderesult &lt;- basic_table() %&gt;%\n  split_cols_by(\"group\", ref_group = levels(df$group)[1]) %&gt;%\n  split_rows_by(\"visit\", split_label = \"Visit\", label_pos = \"topleft\") %&gt;%\n  summarize_rbmi() %&gt;%\n  build_table(df)\nresult\n\nVisit                                       ref                alt       \n—————————————————————————————————————————————————————————————————————————\n4                                                                        \n  Adjusted Mean (SE)                   -1.616 (0.486)     -1.708 (0.475) \n    95% CI                            (-2.576, -0.656)   (-2.645, -0.770)\n  Difference in Adjusted Means (SE)                       -0.092 (0.683) \n    95% CI                                               (-1.439, 1.256) \n    Relative Reduction (%)                                     5.7%      \n    p-value (RBMI)                                            0.8932     \n5                                                                        \n  Adjusted Mean (SE)                   -4.249 (0.652)     -2.831 (0.646) \n    95% CI                            (-5.536, -2.962)   (-4.107, -1.555)\n  Difference in Adjusted Means (SE)                       1.418 (0.919)  \n    95% CI                                               (-0.397, 3.233) \n    Relative Reduction (%)                                    -33.4%     \n    p-value (RBMI)                                            0.1248     \n6                                                                        \n  Adjusted Mean (SE)                   -6.359 (0.710)     -4.131 (0.692) \n    95% CI                            (-7.762, -4.955)   (-5.499, -2.762)\n  Difference in Adjusted Means (SE)                       2.228 (0.996)  \n    95% CI                                                (0.260, 4.196) \n    Relative Reduction (%)                                    -35.0%     \n    p-value (RBMI)                                            0.0268     \n7                                                                        \n  Adjusted Mean (SE)                   -7.642 (0.803)     -4.831 (0.778) \n    95% CI                            (-9.231, -6.053)   (-6.372, -3.291)\n  Difference in Adjusted Means (SE)                       2.811 (1.127)  \n    95% CI                                                (0.580, 5.042) \n    Relative Reduction (%)                                    -36.8%     \n    p-value (RBMI)                                            0.0140     \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] broom_1.0.5      dplyr_1.1.3      tern.rbmi_0.1.2  tern_0.9.0      \n[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2 rbmi_1.2.5      \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0    loo_2.6.0           fastmap_1.1.1      \n [4] TH.data_1.1-2       digest_0.6.33       estimability_1.4.1 \n [7] lifecycle_1.0.3     StanHeaders_2.26.28 survival_3.5-7     \n[10] processx_3.8.2      compiler_4.3.1      rlang_1.1.1        \n[13] tools_4.3.1         utf8_1.2.3          yaml_2.3.7         \n[16] mmrm_0.2.2          knitr_1.44          prettyunits_1.1.1  \n[19] htmlwidgets_1.6.2   pkgbuild_1.4.2      multcomp_1.4-25    \n[22] withr_2.5.0         purrr_1.0.2         numDeriv_2016.8-1.1\n[25] grid_4.3.1          stats4_4.3.1        fansi_1.0.4        \n[28] xtable_1.8-4        colorspace_2.1-0    inline_0.3.19      \n[31] ggplot2_3.4.3       emmeans_1.8.8       scales_1.2.1       \n[34] MASS_7.3-60         cli_3.6.1           mvtnorm_1.2-3      \n[37] rmarkdown_2.25      crayon_1.5.2        generics_0.1.3     \n[40] RcppParallel_5.1.7  rstudioapi_0.15.0   rstan_2.26.23      \n[43] stringr_1.5.0       splines_4.3.1       assertthat_0.2.1   \n[46] parallel_4.3.1      matrixStats_1.0.0   vctrs_0.6.3        \n[49] Matrix_1.6-1.1      sandwich_3.0-2      jsonlite_1.8.7     \n[52] callr_3.7.3         testthat_3.1.10     tidyr_1.3.0        \n[55] glue_1.6.2          codetools_0.2-19    ps_1.7.5           \n[58] stringi_1.7.12      gtable_0.3.4        QuickJSR_1.0.6     \n[61] munsell_0.5.0       tibble_3.2.1        pillar_1.9.0       \n[64] htmltools_0.5.6     brio_1.1.3          R6_2.5.1           \n[67] TMB_1.9.6           Rdpack_2.5          evaluate_0.21      \n[70] lattice_0.21-8      rbibutils_2.2.15    backports_1.4.1    \n[73] Rcpp_1.0.11         coda_0.19-4         gridExtra_2.3      \n[76] nlme_3.1-163        checkmate_2.2.0     xfun_0.40          \n[79] zoo_1.8-12          pkgconfig_2.0.3    \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/cmht01.html",
+    "href": "tables/efficacy/cmht01.html",
+    "title": "CMHT01",
+    "section": "",
+    "text": "Data Setup\nTable of Single Parameter\nTable of Multiple Parameters\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\n\n\n\n\nCodeanl_01 &lt;- adqs %&gt;%\n  filter(PARAMCD == \"FKSI-FWB\" & AVISIT == \"WEEK 1 DAY 8\") %&gt;%\n  mutate(is_rsp = PCHG &gt; 15) %&gt;%\n  mutate(ARM = relevel(ARM, ref = \"A: Drug X\")) %&gt;%\n  var_relabel(ARM = \"Description of Planned Arm\") %&gt;%\n  mutate(strata = interaction(STRATA1, STRATA2, drop = TRUE))\n\nlyt_01 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(vars = \"is_rsp\", table_names = \"est_prop\") %&gt;%\n  estimate_proportion_diff(\n    var_labels = \"Unstratified Analysis\",\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(vars = \"is_rsp\", table_names = \"test_prop\") %&gt;%\n  estimate_odds_ratio(vars = \"is_rsp\", table_names = \"est_or\") %&gt;%\n  estimate_proportion_diff(\n    var_labels = \"Stratified Analysis\",\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    method = \"cmh\",\n    variables = list(strata = \"strata\"),\n    table_names = \"est_prop_diff_strat\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    method = \"cmh\",\n    variables = list(strata = \"strata\"),\n    table_names = \"test_prop_strat\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    variables = list(strata = \"strata\", arm = \"ARM\"),\n    table_names = \"est_or_strat\"\n  )\n\nresult &lt;- build_table(\n  lyt = lyt_01,\n  df = anl_01,\n  alt_counts_df = adsl\n)\nresult\n\n                                            A: Drug X         B: Placebo         C: Combination  \n                                             (N=134)           (N=134)              (N=132)      \n—————————————————————————————————————————————————————————————————————————————————————————————————\nResponders                                  49 (36.6%)        51 (38.1%)           47 (35.6%)    \n95% CI (Wald, with correction)             (28.0, 45.1)      (29.5, 46.7)         (27.1, 44.2)   \nUnstratified Analysis                                                                            \n  Difference in Response rate (%)                                1.5                  -1.0       \n    95% CI (Wald, with correction)                          (-10.8, 13.8)        (-13.3, 11.3)   \n  p-value (Chi-Squared Test)                                    0.8006               0.8704      \nOdds Ratio (95% CI)                                       1.07 (0.65 - 1.75)   0.96 (0.58 - 1.58)\nStratified Analysis                                                                              \n  Difference in Response rate (%)                                2.8                  -1.5       \n    95% CI (CMH, without correction)                         (-8.2, 13.8)         (-13.0, 9.9)   \n  p-value (Cochran-Mantel-Haenszel Test)                        0.6397               0.7952      \nOdds Ratio (95% CI)                                       1.12 (0.68 - 1.83)   0.99 (0.60 - 1.64)\n\n\n\n\n\nCodeanl_02 &lt;- adqs %&gt;%\n  filter(AVISIT == \"WEEK 1 DAY 8\") %&gt;%\n  mutate(is_rsp = PCHG &gt; 15) %&gt;%\n  mutate(PARAM = droplevels(PARAM)) %&gt;%\n  mutate(ARM = relevel(ARM, ref = \"A: Drug X\")) %&gt;%\n  var_relabel(ARM = \"Description of Planned Arm\") %&gt;%\n  mutate(strata = interaction(STRATA1, STRATA2, drop = TRUE))\n\nvar_labels(anl_02)[\"PARAM\"] &lt;- \"Parameter\"\n\nsplit_fun &lt;- drop_split_levels\n\nlyt_02 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  split_rows_by(\n    var = \"PARAM\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(anl_02$PARAM)\n  ) %&gt;%\n  estimate_proportion(vars = \"is_rsp\", table_names = \"est_prop\") %&gt;%\n  estimate_proportion_diff(\n    var_labels = \"Unstratified Analysis\",\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(vars = \"is_rsp\", table_names = \"test_prop\") %&gt;%\n  estimate_odds_ratio(vars = \"is_rsp\", table_names = \"est_or\") %&gt;%\n  estimate_proportion_diff(\n    var_labels = \"Stratified Analysis\",\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    method = \"cmh\",\n    variables = list(strata = \"strata\"),\n    table_names = \"est_prop_diff_strat\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    method = \"cmh\",\n    variables = list(strata = \"strata\"),\n    table_names = \"test_prop_strat\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    variables = list(strata = \"strata\", arm = \"ARM\"),\n    table_names = \"est_or_strat\"\n  )\n\nresult &lt;- build_table(\n  lyt = lyt_02,\n  df = anl_02,\n  alt_counts_df = adsl\n)\nresult\n\nParameter                                     A: Drug X         B: Placebo         C: Combination  \n                                               (N=134)           (N=134)              (N=132)      \n———————————————————————————————————————————————————————————————————————————————————————————————————\nBFI All Questions                                                                                  \n  Responders                                  57 (42.5%)        65 (48.5%)           50 (37.9%)    \n  95% CI (Wald, with correction)             (33.8, 51.3)      (39.7, 57.3)         (29.2, 46.5)   \n  Unstratified Analysis                                                                            \n    Difference in Response rate (%)                                6.0                  -4.7       \n      95% CI (Wald, with correction)                           (-6.7, 18.6)         (-17.2, 7.9)   \n    p-value (Chi-Squared Test)                                    0.3264               0.4385      \n  Odds Ratio (95% CI)                                       1.27 (0.79 - 2.06)   0.82 (0.50 - 1.35)\n  Stratified Analysis                                                                              \n    Difference in Response rate (%)                                6.7                  -5.1       \n      95% CI (CMH, without correction)                         (-5.0, 18.4)         (-16.8, 6.6)   \n    p-value (Cochran-Mantel-Haenszel Test)                        0.2781               0.4056      \n  Odds Ratio (95% CI)                                       1.30 (0.80 - 2.11)   0.80 (0.49 - 1.32)\nFatigue Interference                                                                               \n  Responders                                  66 (49.3%)        50 (37.3%)           48 (36.4%)    \n  95% CI (Wald, with correction)             (40.4, 58.1)      (28.8, 45.9)         (27.8, 44.9)   \n  Unstratified Analysis                                                                            \n    Difference in Response rate (%)                               -11.9                -12.9       \n      95% CI (Wald, with correction)                           (-24.5, 0.6)        (-25.4, -0.3)   \n    p-value (Chi-Squared Test)                                    0.0485               0.0337      \n  Odds Ratio (95% CI)                                       0.61 (0.38 - 1.00)   0.59 (0.36 - 0.96)\n  Stratified Analysis                                                                              \n    Difference in Response rate (%)                               -12.0                -13.3       \n      95% CI (CMH, without correction)                        (-23.7, -0.2)        (-24.9, -1.6)   \n    p-value (Cochran-Mantel-Haenszel Test)                        0.0518               0.0303      \n  Odds Ratio (95% CI)                                       0.61 (0.37 - 0.99)   0.58 (0.36 - 0.96)\nFKSI-19 All Questions                                                                              \n  Responders                                  60 (44.8%)        57 (42.5%)           68 (51.5%)    \n  95% CI (Wald, with correction)             (36.0, 53.6)      (33.8, 51.3)         (42.6, 60.4)   \n  Unstratified Analysis                                                                            \n    Difference in Response rate (%)                                -2.2                 6.7        \n      95% CI (Wald, with correction)                          (-14.9, 10.4)         (-6.0, 19.5)   \n    p-value (Chi-Squared Test)                                    0.7118               0.2714      \n  Odds Ratio (95% CI)                                       0.91 (0.56 - 1.48)   1.31 (0.81 - 2.12)\n  Stratified Analysis                                                                              \n    Difference in Response rate (%)                                -2.8                 5.6        \n      95% CI (CMH, without correction)                         (-14.3, 8.8)         (-6.2, 17.4)   \n    p-value (Cochran-Mantel-Haenszel Test)                        0.6442               0.3683      \n  Odds Ratio (95% CI)                                       0.90 (0.56 - 1.47)   1.26 (0.77 - 2.04)\nFunction/Well-Being (GF1,GF3,GF7)                                                                  \n  Responders                                  49 (36.6%)        51 (38.1%)           47 (35.6%)    \n  95% CI (Wald, with correction)             (28.0, 45.1)      (29.5, 46.7)         (27.1, 44.2)   \n  Unstratified Analysis                                                                            \n    Difference in Response rate (%)                                1.5                  -1.0       \n      95% CI (Wald, with correction)                          (-10.8, 13.8)        (-13.3, 11.3)   \n    p-value (Chi-Squared Test)                                    0.8006               0.8704      \n  Odds Ratio (95% CI)                                       1.07 (0.65 - 1.75)   0.96 (0.58 - 1.58)\n  Stratified Analysis                                                                              \n    Difference in Response rate (%)                                2.8                  -1.5       \n      95% CI (CMH, without correction)                         (-8.2, 13.8)         (-13.0, 9.9)   \n    p-value (Cochran-Mantel-Haenszel Test)                        0.6397               0.7952      \n  Odds Ratio (95% CI)                                       1.12 (0.68 - 1.83)   0.99 (0.60 - 1.64)\nTreatment Side Effects (GP2,C5,GP5)                                                                \n  Responders                                  62 (46.3%)        49 (36.6%)           51 (38.6%)    \n  95% CI (Wald, with correction)             (37.5, 55.1)      (28.0, 45.1)         (30.0, 47.3)   \n  Unstratified Analysis                                                                            \n    Difference in Response rate (%)                                -9.7                 -7.6       \n      95% CI (Wald, with correction)                           (-22.2, 2.8)         (-20.2, 5.0)   \n    p-value (Chi-Squared Test)                                    0.1069               0.2080      \n  Odds Ratio (95% CI)                                       0.67 (0.41 - 1.09)   0.73 (0.45 - 1.19)\n  Stratified Analysis                                                                              \n    Difference in Response rate (%)                                -9.6                 -7.1       \n      95% CI (CMH, without correction)                         (-21.0, 1.8)         (-18.8, 4.6)   \n    p-value (Cochran-Mantel-Haenszel Test)                        0.1168               0.2426      \n  Odds Ratio (95% CI)                                       0.67 (0.41 - 1.10)   0.73 (0.45 - 1.19)\n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\narm_ref_comp &lt;- list(\n  ARMCD = list(ref = \"ARM B\", comp = c(\"ARM A\", \"ARM C\")),\n  ARM = list(ref = \"B: Placebo\", comp = c(\"A: Drug X\", \"C: Combination\"))\n)\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL),\n    cdisc_dataset(\"ADRS\", ADRS),\n    code =\n      'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")'\n  ),\n  modules = modules(\n    tm_t_binary_outcome(\n      label = \"Responders\",\n      dataname = \"ADRS\",\n      paramcd = choices_selected(\n        choices = value_choices(ADRS, \"PARAMCD\", \"PARAM\"),\n        selected = \"BESRSPI\"\n      ),\n      arm_var = choices_selected(\n        choices = variable_choices(ADRS, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        selected = \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      strata_var = choices_selected(\n        choices = variable_choices(ADRS, c(\"SEX\", \"BMRKR2\")),\n        select = NULL\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:02:37.5383 pid:7953 token:[] teal.modules.clinical Initializing tm_t_binary_outcome\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/cfbt01.html",
+    "href": "tables/efficacy/cfbt01.html",
+    "title": "CFBT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\n# This example focuses on \"BFI All Questions\" starting from baseline.\nadqs &lt;- adqs %&gt;%\n  dplyr::filter(\n    PARAM == \"BFI All Questions\",\n    AVISIT != \"SCREENING\"\n  )\n\n# Define the split function for AVISIT\nsplit_fun &lt;- drop_split_levels\n\n\n\n\n\nCodeafun &lt;- function(x, .var, .spl_context, ...) {\n  n_fun &lt;- sum(!is.na(x), na.rm = TRUE)\n  if (n_fun == 0) {\n    mean_sd_fun &lt;- c(NA, NA)\n    median_fun &lt;- NA\n    min_max_fun &lt;- c(NA, NA)\n  } else {\n    mean_sd_fun &lt;- c(mean(x, na.rm = TRUE), sd(x, na.rm = TRUE))\n    median_fun &lt;- median(x, na.rm = TRUE)\n    min_max_fun &lt;- c(min(x), max(x))\n  }\n  is_chg &lt;- .var == \"CHG\"\n  is_baseline &lt;- .spl_context$value[which(.spl_context$split == \"AVISIT\")] == \"BASELINE\"\n  if (is_baseline && is_chg) n_fun &lt;- mean_sd_fun &lt;- median_fun &lt;- min_max_fun &lt;- NULL\n\n  in_rows(\n    \"n\" = n_fun,\n    \"Mean (SD)\" = mean_sd_fun,\n    \"Median\" = median_fun,\n    \"Min - Max\" = min_max_fun,\n    .formats = list(\"n\" = \"xx\", \"Mean (SD)\" = \"xx.xx (xx.xx)\", \"Median\" = \"xx.xx\", \"Min - Max\" = \"xx.xx - xx.xx\"),\n    .format_na_strs = list(\"n\" = \"NE\", \"Mean (SD)\" = \"NE (NE)\", \"Median\" = \"NE\", \"Min - Max\" = \"NE - NE\")\n  )\n}\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adqs$PARAM)\n  ) %&gt;%\n  split_rows_by(\n    \"AVISIT\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adqs$AVISIT)\n  ) %&gt;%\n  split_cols_by_multivar(\n    vars = c(\"AVAL\", \"CHG\"),\n    varlabels = c(\"Value at Visit\", \"Change from\\nBaseline\")\n  ) %&gt;%\n  analyze_colvars(afun = afun)\n\nresult &lt;- build_table(lyt, adqs)\nresult\n\nParameter                      A: Drug X                        B: Placebo                      C: Combination         \n  Analysis Visit                      Change from                       Change from                       Change from  \n                    Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nBFI All Questions                                                                                                      \n  BASELINE                                                                                                             \n    n                    134                               134                               132                       \n    Mean (SD)        49.93 (7.44)                      49.74 (8.29)                      50.30 (9.06)                  \n    Median              48.69                             49.28                             49.74                      \n    Min - Max       33.72 - 65.91                     25.82 - 71.47                     26.04 - 69.99                  \n  WEEK 1 DAY 8                                                                                                         \n    n                    134              134              134              134              132              132      \n    Mean (SD)        54.51 (8.61)     4.58 (11.23)     56.33 (7.86)     6.59 (11.81)     54.03 (8.31)     3.72 (12.66) \n    Median              55.15             5.47            56.39             6.96            53.76             3.71     \n    Min - Max       34.26 - 75.42    -25.52 - 29.68   36.82 - 74.45    -25.10 - 31.05   26.89 - 75.95    -26.81 - 33.75\n  WEEK 2 DAY 15                                                                                                        \n    n                    134              134              134              134              132              132      \n    Mean (SD)       60.98 (10.31)    11.05 (12.46)     59.68 (9.59)     9.94 (12.84)     60.11 (8.76)     9.80 (12.59) \n    Median              60.60            10.45            58.18             8.95            61.08            10.04     \n    Min - Max       35.94 - 96.53    -14.02 - 45.01   40.44 - 84.70    -17.59 - 40.52   32.76 - 78.25    -26.57 - 39.56\n  WEEK 3 DAY 22                                                                                                        \n    n                    134              134              134              134              132              132      \n    Mean (SD)        64.64 (9.88)    14.72 (11.99)    65.78 (10.17)    16.04 (13.80)    63.65 (10.50)    13.35 (13.39) \n    Median              65.21            15.10            66.28            15.49            63.79            12.24     \n    Min - Max       40.49 - 95.35    -16.76 - 43.40   42.16 - 92.32    -17.70 - 46.85   29.29 - 88.41    -22.40 - 39.94\n  WEEK 4 DAY 29                                                                                                        \n    n                    134              134              134              134              132              132      \n    Mean (SD)       69.43 (11.12)    19.51 (13.83)    69.79 (11.46)    20.05 (14.38)    70.68 (10.23)    20.37 (12.99) \n    Median              69.22            19.90            70.37            20.99            70.85            20.94     \n    Min - Max       38.38 - 95.48    -17.34 - 49.18   45.79 - 93.33    -19.66 - 58.05   30.53 - 90.61    -14.01 - 60.23\n  WEEK 5 DAY 36                                                                                                        \n    n                    134              134              134              134              132              132      \n    Mean (SD)       74.31 (12.44)    24.38 (14.75)    74.73 (12.96)    24.99 (14.67)    75.89 (13.54)    25.59 (17.18) \n    Median              76.12            25.20            74.13            22.81            76.70            25.32     \n    Min - Max       39.45 - 103.92   -7.53 - 56.23    38.19 - 109.61   -18.42 - 64.15   43.79 - 102.40   -16.11 - 67.78\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\",\n      adsl,\n      code = 'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'\n    ),\n    cdisc_dataset(\"ADQS\",\n      adqs,\n      code = 'adqs &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adqs\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Efficacy Data and Change from Baseline by Visit\",\n      dataname = \"ADQS\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adqs, c(\"PARAM\", \"AVISIT\")),\n        selected = c(\"AVISIT\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adqs, c(\"AVAL\", \"CHG\")),\n        selected = c(\"AVAL\", \"CHG\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adqs, \"PARAMCD\", \"PARAM\"),\n        selected = \"BFIALL\"\n      ),\n      add_total = FALSE,\n      parallel_vars = TRUE\n    )\n  ),\n  filter = list(ADQS = list(AVISIT = list(), AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:00:58.1333 pid:7755 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/lgrt02.html",
+    "href": "tables/efficacy/lgrt02.html",
+    "title": "LGRT02",
+    "section": "",
+    "text": "Data Setup\nMulti-Variable Logistic Regression\nMulti-Variable Logistic Regression  with Interaction Term\nMulti-Variable Logistic Regression  Specifying Covariates\nMulti-Variable Logistic Regression Setting  an Event, Alpha Level, and Level for Interaction\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadrs &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadrs &lt;- df_explicit_na(adrs)\n\nadsl &lt;- adsl %&gt;%\n  dplyr::filter(SEX %in% c(\"F\", \"M\"))\n\nadrs &lt;- adrs %&gt;%\n  dplyr::filter(PARAMCD == \"BESRSPI\") %&gt;%\n  dplyr::mutate(\n    Response = case_when(AVALC %in% c(\"PR\", \"CR\") ~ 1, TRUE ~ 0),\n    SEX = factor(SEX, c(\"M\", \"F\")),\n    RACE = factor(\n      RACE,\n      levels = c(\n        \"AMERICAN INDIAN OR ALASKA NATIVE\", \"ASIAN\", \"BLACK OR AFRICAN AMERICAN\",\n        \"WHITE\", \"MULTIPLE\", \"NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER\"\n      )\n    )\n  ) %&gt;%\n  var_relabel(Response = \"Response\", SEX = \"Sex\", RACE = \"Race\")\n\n\n\n\n\nCodemodel &lt;- fit_logistic(\n  adrs,\n  variables = list(response = \"Response\", arm = \"ARMCD\", covariates = c(\"SEX\", \"AGE\"))\n)\nconf_level &lt;- 0.95\ndf &lt;- broom::tidy(model, conf_level = conf_level)\n\n# empty string flag\ndf &lt;- df_explicit_na(df, na_level = \"_NA_\")\n\nresult &lt;- basic_table() %&gt;%\n  summarize_logistic(\n    conf_level = conf_level,\n    drop_and_remove_str = \"_NA_\"\n  ) %&gt;%\n  append_topleft(\"Logistic regression\") %&gt;%\n  build_table(df = df)\nresult\n\nLogistic regression          Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio    Wald 95% CI    p-value\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nPlanned Arm Code                     2                                                                               0.0408 \n  Reference ARM A, n = 134                                                                                                  \n  ARM B, n = 134                     1                  -2.094             1.080           0.12      (0.01, 1.02)    0.0524 \n  ARM C, n = 132                     1                  -0.074             1.423           0.93      (0.06, 15.09)   0.9584 \nSex                                                                                                                         \n  Reference M, n = 169                                                                                                      \n  F, n = 231                         1                  0.331              0.695           1.39      (0.36, 5.44)    0.6339 \nAge                                                                                                                         \n  Age                                1                  0.070              0.054           1.07      (0.97, 1.19)    0.1945 \n\n\n\n\n\nCodemodel &lt;- fit_logistic(\n  adrs,\n  variables = list(\n    response = \"Response\",\n    arm = \"ARMCD\",\n    covariates = c(\"SEX\", \"AGE\"),\n    interaction = \"SEX\"\n  )\n)\nconf_level &lt;- 0.95\ndf &lt;- broom::tidy(model, conf_level = conf_level)\n\n# empty string flag\ndf &lt;- df_explicit_na(df, na_level = \"_NA_\")\n\nresult &lt;- basic_table() %&gt;%\n  summarize_logistic(\n    conf_level = conf_level,\n    drop_and_remove_str = \"_NA_\"\n  ) %&gt;%\n  append_topleft(\"Logistic regression with interaction\") %&gt;%\n  build_table(df = df)\nresult\n\nLogistic regression with interaction    Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 95% CI     p-value\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAge                                                                                                                                      \n  Age                                           1                  0.067              0.054           1.07       (0.96, 1.19)     0.2084 \nPlanned Arm Code                                2                                                                                 0.4882 \n  Reference ARM A, n = 134                                                                                                               \n  ARM B, n = 134                                1                 -17.850            2362.767                                     0.9940 \n    Sex                                                                                                                                  \n      F                                                                                               0.23       (0.02, 2.11)            \n      M                                                                                               0.00      (0.00, &gt;999.99)          \n  ARM C, n = 132                                1                 -16.442            2362.767                                     0.9944 \n    Sex                                                                                                                                  \n      F                                                                                             &gt;999.99     (0.00, &gt;999.99)          \n      M                                                                                               0.00      (0.00, &gt;999.99)          \nSex                                                                                                                                      \n  Reference M, n = 169                                                                                                                   \n  F, n = 231                                    1                 -16.044            2362.767                                     0.9946 \n    Planned Arm Code                                                                                                                     \n      ARM A                                                                                           0.00      (0.00, &gt;999.99)          \n      ARM B                                                                                           1.39       (0.29, 6.59)            \n      ARM C                                                                                         &gt;999.99     (0.00, &gt;999.99)          \nInteraction of Planned Arm Code * Sex           2                                                                                 0.9999 \n  Reference ARM A or M, n = 248                                                                                                          \n  ARM B * F, n = 82                             1                  16.373            2362.767                                     0.9945 \n  ARM C * F, n = 70                             1                  32.492            3156.732                                     0.9918 \n\n\n\n\n\nCodemodel &lt;- fit_logistic(\n  adrs,\n  variables = list(\n    response = \"Response\",\n    arm = \"ARMCD\",\n    covariates = c(\"SEX\", \"AGE\", \"RACE\")\n  )\n)\nconf_level &lt;- 0.95\ndf &lt;- broom::tidy(model, conf_level = conf_level)\n\n# empty string flag\ndf &lt;- df_explicit_na(df, na_level = \"_NA_\")\n\nresult &lt;- basic_table() %&gt;%\n  summarize_logistic(\n    conf_level = conf_level,\n    drop_and_remove_str = \"_NA_\"\n  ) %&gt;%\n  append_topleft(\"y ~ ARM + SEX + AGE + RACE\") %&gt;%\n  build_table(df = df)\nresult\n\ny ~ ARM + SEX + AGE + RACE                             Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 95% CI     p-value\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nPlanned Arm Code                                               2                                                                                 0.0346 \n  Reference ARM A, n = 134                                                                                                                              \n  ARM B, n = 134                                               1                  -2.162             1.084           0.12       (0.01, 0.96)     0.0461 \n  ARM C, n = 132                                               1                  -0.090             1.426           0.91       (0.06, 14.97)    0.9499 \nSex                                                                                                                                                     \n  Reference M, n = 169                                                                                                                                  \n  F, n = 231                                                   1                  0.364              0.701           1.44       (0.36, 5.69)     0.6032 \nAge                                                                                                                                                     \n  Age                                                          1                  0.071              0.053           1.07       (0.97, 1.19)     0.1866 \nRace                                                           5                                                                                 0.9685 \n  Reference AMERICAN INDIAN OR ALASKA NATIVE, n = 25                                                                                                    \n  ASIAN, n = 208                                               1                 -16.246            2017.122         0.00      (0.00, &gt;999.99)   0.9936 \n  BLACK OR AFRICAN AMERICAN, n = 91                            1                 -15.205            2017.122         0.00      (0.00, &gt;999.99)   0.9940 \n  WHITE, n = 74                                                1                 -15.955            2017.122         0.00      (0.00, &gt;999.99)   0.9937 \n  MULTIPLE, n = 1                                              1                  -0.363           10941.553         0.70      (0.00, &gt;999.99)   1.0000 \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER, n = 1             1                  1.036            10941.553         2.82      (0.00, &gt;999.99)   0.9999 \n\n\n\n\n\nCodemodel &lt;- fit_logistic(\n  adrs,\n  variables = list(\n    response = \"Response\",\n    arm = \"ARMCD\",\n    covariates = c(\"SEX\", \"AGE\"),\n    interaction = \"AGE\"\n  ),\n  response_definition = \"1 - response\"\n)\nconf_level &lt;- 0.9\ndf &lt;- broom::tidy(model, conf_level = conf_level, at = c(30, 50))\n\n# empty string flag\ndf &lt;- df_explicit_na(df, na_level = \"_NA_\")\n\nresult &lt;- basic_table() %&gt;%\n  summarize_logistic(\n    conf_level = conf_level,\n    drop_and_remove_str = \"_NA_\"\n  ) %&gt;%\n  append_topleft(\"Estimations at age 30 and 50\") %&gt;%\n  build_table(df = df)\nresult\n\nEstimations at age 30 and 50            Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 90% CI      p-value\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nSex                                                                                                                                       \n  Reference M, n = 169                                                                                                                    \n  F, n = 231                                    1                  -0.381             0.710           0.68        (0.21, 2.20)     0.5915 \nPlanned Arm Code                                2                                                                                  0.2768 \n  Reference ARM A, n = 134                                                                                                                \n  ARM B, n = 134                                1                 -20.020             13.714                                       0.1443 \n    Age                                                                                                                                   \n      30                                                                                             234.91     (0.30, &gt;999.99)           \n      50                                                                                            &gt;999.99     (0.04, &gt;999.99)           \n  ARM C, n = 132                                1                 -15.622             14.810                                       0.2915 \n    Age                                                                                                                                   \n      30                                                                                             31.95      (0.03, &gt;999.99)           \n      50                                                                                            &gt;999.99     (&lt;0.01, &gt;999.99)          \nAge                                                                                                                                       \n  Age                                           1                  -0.877             0.581                                        0.1309 \n    Planned Arm Code                                                                                                                      \n      ARM A                                                                                           0.42        (0.16, 1.08)            \n      ARM B                                                                                           0.97        (0.89, 1.06)            \n      ARM C                                                                                           0.79        (0.55, 1.11)            \nInteraction of Planned Arm Code * Age           2                                                                                  0.2213 \n  Reference ARM A, n = 134                                                                                                                \n  ARM B, n = 134                                1                  0.849              0.583                                        0.1449 \n  ARM C, n = 132                                1                  0.636              0.618                                        0.3034 \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\") %&gt;%\n  filter(PARAMCD %in% c(\"BESRSPI\", \"INVET\"))\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\n      \"ADRS\", ADRS,\n      code = 'ADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\") %&gt;% filter(PARAMCD %in% c(\"BESRSPI\", \"INVET\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_logistic(\n      label = \"Logistic Regression\",\n      dataname = \"ADRS\",\n      arm_var = choices_selected(\n        choices = variable_choices(ADRS, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        choices = value_choices(ADRS, \"PARAMCD\", \"PARAM\"),\n        selected = \"BESRSPI\"\n      ),\n      cov_var = choices_selected(\n        choices = c(\"SEX\", \"AGE\", \"BMRKR1\", \"BMRKR2\"),\n        selected = \"SEX\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:59:41.2210 pid:7559 token:[] teal.modules.clinical Initializing tm_t_logistic\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          \n[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        \n[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    \n[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        \n[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          \n[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       \n[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         \n[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          \n[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       \n[49] jsonlite_1.8.7        carData_3.0-5         callr_3.7.3          \n[52] car_3.1-2             teal.widgets_0.4.0    testthat_3.1.10      \n[55] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[58] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[61] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[64] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[67] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[70] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[73] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[76] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[79] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          \n[82] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[85] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[88] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/ttet01.html",
+    "href": "tables/efficacy/ttet01.html",
+    "title": "TTET01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting  Sections to Display\nTable Modifying Analysis Details  like Conf. Type, Ties, Alpha Level\nTable with  Stratified Analysis\nTable Modifying Time Point for  the “XX Months” Analysis\nTable Requesting  &gt; 1 p-value\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure that character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadtte &lt;- df_explicit_na(adtte)\n\nadtte_f &lt;- adtte %&gt;%\n  dplyr::filter(PARAMCD == \"OS\") %&gt;%\n  dplyr::mutate(\n    AVAL = day2month(AVAL),\n    is_event = CNSR == 0,\n    is_not_event = CNSR == 1,\n    EVNT1 = factor(\n      case_when(\n        is_event == TRUE ~ \"Patients with event (%)\",\n        is_event == FALSE ~ \"Patients without event (%)\"\n      ),\n      levels = c(\"Patients with event (%)\", \"Patients without event (%)\")\n    ),\n    EVNTDESC = factor(EVNTDESC)\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    var = \"ARM\", ref_group = \"A: Drug X\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Patients with event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 1L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    time_point = c(6, 12),\n    is_event = \"is_event\",\n    method = \"both\",\n    control = control_surv_timepoint()\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\n                                    A: Drug X        B: Placebo      C: Combination\n                                     (N=134)           (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nPatients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  \n  Earliest contributing event                                                      \n    Death                               58               58                69      \nPatients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  \nTime to Event (Months)                                                             \n  Median                                NA               NA               9.4      \n    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   \n  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    \n  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  \n  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  \nUnstratified Analysis                                                              \n  p-value (log-rank)                                   0.9998            0.1541    \n  Hazard Ratio                                          1.00              1.29     \n  95% CI                                            (0.69, 1.44)      (0.91, 1.83) \n6 Months                                                                           \n  Patients remaining at risk            97               97                90      \n  Event Free Rate (%)                 72.39             72.39            68.18     \n  95% CI                          (64.82, 79.96)   (64.82, 79.96)    (60.24, 76.13)\n  Difference in Event Free Rate                         0.00             -4.21     \n    95% CI                                         (-10.71, 10.71)   (-15.18, 6.77)\n    p-value (Z-test)                                   1.0000            0.4525    \n12 Months                                                                          \n  Patients remaining at risk            49               48                37      \n  Event Free Rate (%)                 56.72             56.72            47.73     \n  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)\n  Difference in Event Free Rate                         0.00             -8.99     \n    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)\n    p-value (Z-test)                                   1.0000            0.1406    \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  analyze_vars(\n    \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    is_event = \"is_event\",\n    method = \"surv\",\n    time_point = c(6, 12)\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl)\nresult\n\n                                 A: Drug X        B: Placebo     C: Combination\n                                  (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————\nPatients with event (%)          58 (43.3%)       58 (43.3%)       69 (52.3%)  \nPatients without event (%)       76 (56.7%)       76 (56.7%)       63 (47.7%)  \nTime to Event (Months)                                                         \n  Median                             NA               NA              9.4      \n    95% CI                       (9.3, NA)        (9.4, NA)        (7.6, NA)   \n  25% and 75%-ile                 5.6, NA          5.6, NA          5.0, NA    \n  Range (censored)              9.9 to 16.4      9.9 to 16.3      9.9 to 16.3  \n  Range (event)                  0.5 to 9.6       0.9 to 9.6       0.5 to 9.8  \nUnstratified Analysis                                                          \n  p-value (log-rank)                                0.9998           0.1541    \n  Hazard Ratio                                       1.00             1.29     \n  95% CI                                         (0.69, 1.44)     (0.91, 1.83) \n6 Months                                                                       \n  Patients remaining at risk         97               97               90      \n  Event Free Rate (%)              72.39            72.39            68.18     \n  95% CI                       (64.82, 79.96)   (64.82, 79.96)   (60.24, 76.13)\n12 Months                                                                      \n  Patients remaining at risk         49               48               37      \n  Event Free Rate (%)              56.72            56.72            47.73     \n  95% CI                       (48.33, 65.11)   (48.33, 65.11)   (39.21, 56.25)\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Patients with event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 1L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    control = control_surv_time(conf_level = 0.9, conf_type = \"log-log\"),\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(\n      pval_method = \"log-rank\",\n      conf_level = 0.95,\n      ties = \"efron\"\n    ),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    is_event = \"is_event\",\n    time_point = 12,\n    control = control_surv_timepoint(conf_level = 0.9, conf_type = \"log-log\"),\n    table_names_suffix = \"_log_log\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    show_labels = \"hidden\",\n    is_event = \"is_event\",\n    time_point = 12,\n    method = \"surv_diff\",\n    control = control_surv_timepoint(conf_level = 0.975),\n    table_names_suffix = \"_975_pct\"\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\n                                  A: Drug X        B: Placebo      C: Combination\n                                   (N=134)           (N=134)          (N=132)    \n—————————————————————————————————————————————————————————————————————————————————\nPatients with event (%)           58 (43.3%)       58 (43.3%)        69 (52.3%)  \n  Earliest contributing event                                                    \n    Death                             58               58                69      \nPatients without event (%)        76 (56.7%)       76 (56.7%)        63 (47.7%)  \nTime to Event (Months)                                                           \n  Median                              NA               NA               9.4      \n    90% CI                        (9.6, NA)         (9.6, NA)        (7.7, NA)   \n  25% and 75%-ile                  5.6, NA           5.6, NA          5.0, NA    \n  Range (censored)               9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  \n  Range (event)                   0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  \nUnstratified Analysis                                                            \n  p-value (log-rank)                                 0.9998            0.1541    \n  Hazard Ratio                                        1.00              1.29     \n  95% CI                                          (0.69, 1.44)      (0.91, 1.83) \n12 Months                                                                        \n  Patients remaining at risk          49               48                37      \n  Event Free Rate (%)               56.72             56.72            47.73     \n  90% CI                        (49.37, 63.41)   (49.37, 63.41)    (40.42, 54.66)\nDifference in Event Free Rate                         0.00             -8.99     \n  97.5% CI                                       (-13.57, 13.57)   (-22.66, 4.69)\n  p-value (Z-test)                                   1.0000            0.1406    \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Patients with event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 1L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Unstratified Analysis\",\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Stratified Analysis\",\n    strat = \"SEX\",\n    table_names = \"coxph_stratified\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    is_event = \"is_event\",\n    method = \"both\",\n    time_point = 12\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\n                                    A: Drug X        B: Placebo      C: Combination\n                                     (N=134)           (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nPatients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  \n  Earliest contributing event                                                      \n    Death                               58               58                69      \nPatients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  \nTime to Event (Months)                                                             \n  Median                                NA               NA               9.4      \n    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   \n  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    \n  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  \n  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  \nUnstratified Analysis                                                              \n  p-value (log-rank)                                   0.9998            0.1541    \n  Hazard Ratio                                          1.00              1.29     \n  95% CI                                            (0.69, 1.44)      (0.91, 1.83) \nStratified Analysis                                                                \n  p-value (log-rank)                                   0.9978            0.1733    \n  Hazard Ratio                                          1.00              1.27     \n  95% CI                                            (0.69, 1.44)      (0.90, 1.81) \n12 Months                                                                          \n  Patients remaining at risk            49               48                37      \n  Event Free Rate (%)                 56.72             56.72            47.73     \n  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)\n  Difference in Event Free Rate                         0.00             -8.99     \n    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)\n    p-value (Z-test)                                   1.0000            0.1406    \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Patients with event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 1L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    is_event = \"is_event\",\n    time_point = 6,\n    method = \"both\"\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\n                                    A: Drug X        B: Placebo      C: Combination\n                                     (N=134)           (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nPatients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  \n  Earliest contributing event                                                      \n    Death                               58               58                69      \nPatients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  \nTime to Event (Months)                                                             \n  Median                                NA               NA               9.4      \n    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   \n  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    \n  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  \n  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  \nUnstratified Analysis                                                              \n  p-value (log-rank)                                   0.9998            0.1541    \n  Hazard Ratio                                          1.00              1.29     \n  95% CI                                            (0.69, 1.44)      (0.91, 1.83) \n6 Months                                                                           \n  Patients remaining at risk            97               97                90      \n  Event Free Rate (%)                 72.39             72.39            68.18     \n  95% CI                          (64.82, 79.96)   (64.82, 79.96)    (60.24, 76.13)\n  Difference in Event Free Rate                         0.00             -4.21     \n    95% CI                                         (-10.71, 10.71)   (-15.18, 6.77)\n    p-value (Z-test)                                   1.0000            0.4525    \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients with event (%)\")\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Patients with event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 1L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Patients without event (%)\"),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Time to Event (Months)\",\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(pval_method = \"log-rank\"),\n    .stats = \"pvalue\",\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    show_labels = \"hidden\",\n    control = control_coxph(pval_method = \"wald\"),\n    .stats = \"pvalue\",\n    .indent_mods = c(pvalue = 1L),\n    table_names = \"coxph_wald_pvalue\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    show_labels = \"hidden\",\n    control = control_coxph(pval_method = \"likelihood\"),\n    .indent_mods = c(pvalue = 1L, hr = 2L, hr_ci = 3L),\n    table_names = \"coxph_likelihood_pvalue\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months\",\n    is_event = \"is_event\",\n    time_point = 12,\n    method = \"both\"\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table()\n\nresult\n\n                                    A: Drug X        B: Placebo      C: Combination\n                                     (N=134)           (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————\nPatients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  \n  Earliest contributing event                                                      \n    Death                               58               58                69      \nPatients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  \nTime to Event (Months)                                                             \n  Median                                NA               NA               9.4      \n    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   \n  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    \n  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  \n  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  \nUnstratified Analysis                                                              \n  p-value (log-rank)                                   0.9998            0.1541    \n  p-value (wald)                                       0.9998            0.1552    \n  p-value (likelihood)                                 0.9998            0.1543    \n    Hazard Ratio                                        1.00              1.29     \n      95% CI                                        (0.69, 1.44)      (0.91, 1.83) \n12 Months                                                                          \n  Patients remaining at risk            49               48                37      \n  Event Free Rate (%)                 56.72             56.72            47.73     \n  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)\n  Difference in Event Free Rate                         0.00             -8.99     \n    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)\n    p-value (Z-test)                                   1.0000            0.1406    \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadtte &lt;- df_explicit_na(adtte)\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% df_explicit_na()'),\n    cdisc_dataset(\"ADTTE\", adtte, code = 'ADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\") %&gt;% df_explicit_na()'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_tte(\n      label = \"Time To Event Table\",\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(\n        variable_choices(adsl, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adtte, \"PARAMCD\", \"PARAM\"),\n        \"OS\"\n      ),\n      strata_var = choices_selected(\n        variable_choices(adsl, c(\"SEX\", \"BMRKR2\")),\n        \"SEX\"\n      ),\n      time_points = choices_selected(c(6, 8), 6),\n      event_desc_var = choices_selected(\n        variable_choices(adtte, \"EVNTDESC\"),\n        \"EVNTDESC\",\n        fixed = TRUE\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:58:12.0132 pid:7363 token:[] teal.modules.clinical Initializing tm_t_tte\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/rspt01.html",
+    "href": "tables/efficacy/rspt01.html",
+    "title": "RSPT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting  Sections to Display\nTable Modifying Analysis Details like Type of  Confidence Interval, Alpha Level, Test Statistic\nTable with  Stratified Analysis\nTable Modifying the Definition  of Overall Response\nTable Defining New  Sections to Display\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadrs &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadrs &lt;- df_explicit_na(adrs)\n\nanl_adrs &lt;- adrs %&gt;%\n  filter(PARAMCD == \"INVET\") %&gt;%\n  select(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)\nanl_adsl &lt;- adsl %&gt;%\n  select(STUDYID, USUBJID, ARM, STRATA1)\n\n\nData pre-processing is done to label the analysis value (AVALC) so as to improve the readability of the output table. In addition, the response is binary defined (is_rsp, responder yes/no) depending on the analysis value. Finally, for comparison purposes, the reference arm is specified.\n\nCode# Pre-Processing\n\nanl &lt;- anl_adsl %&gt;%\n  left_join(anl_adrs, by = c(\"STUDYID\", \"USUBJID\")) %&gt;%\n  mutate(rsp_lab = d_onco_rsp_label(AVALC)) %&gt;%\n  mutate(is_rsp = AVALC %in% c(\"CR\", \"PR\")) %&gt;%\n  mutate(ARM = relevel(ARM, ref = \"A: Drug X\")) %&gt;%\n  var_relabel(ARM = \"Description of Planned Arm\")\n\n\n\n\nThe tabulation layout is built in layers for the analysis of overall response and applied to the pre-processed dataset.\n\nCodelyt_01 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"is_rsp\",\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    var_labels = \"Unstratified Analysis\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    table_names = \"test_prop_diff\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    table_names = \"est_or\"\n  ) %&gt;%\n  estimate_multinomial_response(var = \"rsp_lab\")\n\nresult &lt;- build_table(lyt = lyt_01, df = anl)\nresult\n\n                                       A: Drug X          B: Placebo         C: Combination  \n                                        (N=134)            (N=134)              (N=132)      \n—————————————————————————————————————————————————————————————————————————————————————————————\nResponders                            100 (74.6%)         84 (62.7%)           81 (61.4%)    \n95% CI (Wald, with correction)        (66.9, 82.4)       (54.1, 71.2)         (52.7, 70.0)   \nUnstratified Analysis                                                                        \n  Difference in Response rate (%)                           -11.9                -13.3       \n    95% CI (Wald, with correction)                      (-23.7, -0.2)        (-25.1, -1.4)   \n  p-value (Chi-Squared Test)                                0.0351               0.0204      \nOdds Ratio (95% CI)                                   0.57 (0.34 - 0.96)   0.54 (0.32 - 0.91)\nComplete Response (CR)                 60 (44.8%)         47 (35.1%)           57 (43.2%)    \n  95% CI (Wald, with correction)     (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  \nPartial Response (PR)                  40 (29.9%)         37 (27.6%)           24 (18.2%)    \n  95% CI (Wald, with correction)     (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  \nStable Disease (SD)                     9 (6.7%)          22 (16.4%)           13 (9.8%)     \n  95% CI (Wald, with correction)     (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   \nProgressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    \n  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  \nNot Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     \n  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   \n\n\n\n\nRemove (or add) rows of results by removing/adding the corresponding layers from the layout. For instance, the odds-ratio row is removed by simply removing the estimate_odds_ratio call:\n\nCodelyt_02 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"is_rsp\",\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    var_labels = \"Unstratified Analysis\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    table_names = \"test_prop\"\n  ) %&gt;%\n  estimate_multinomial_response(var = \"rsp_lab\")\n\nresult &lt;- build_table(lyt = lyt_02, df = anl)\nresult\n\n                                       A: Drug X        B: Placebo     C: Combination\n                                        (N=134)          (N=134)          (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\nResponders                            100 (74.6%)       84 (62.7%)       81 (61.4%)  \n95% CI (Wald, with correction)        (66.9, 82.4)     (54.1, 71.2)     (52.7, 70.0) \nUnstratified Analysis                                                                \n  Difference in Response rate (%)                         -11.9            -13.3     \n    95% CI (Wald, with correction)                    (-23.7, -0.2)    (-25.1, -1.4) \n  p-value (Chi-Squared Test)                              0.0351           0.0204    \nComplete Response (CR)                 60 (44.8%)       47 (35.1%)       57 (43.2%)  \n  95% CI (Wald, with correction)     (35.98, 53.57)   (26.62, 43.53)   (34.35, 52.01)\nPartial Response (PR)                  40 (29.9%)       37 (27.6%)       24 (18.2%)  \n  95% CI (Wald, with correction)     (21.73, 37.97)   (19.67, 35.55)   (11.22, 25.14)\nStable Disease (SD)                     9 (6.7%)        22 (16.4%)       13 (9.8%)   \n  95% CI (Wald, with correction)     (2.11, 11.33)    (9.77, 23.06)    (4.39, 15.31) \nProgressive Disease (PD)               24 (17.9%)       16 (11.9%)       33 (25.0%)  \n  95% CI (Wald, with correction)     (11.05, 24.78)   (6.08, 17.80)    (17.23, 32.77)\nNot Evaluable (NE)                      1 (0.7%)        12 (9.0%)         5 (3.8%)   \n  95% CI (Wald, with correction)      (0.00, 2.58)    (3.75, 14.16)     (0.15, 7.42) \n\n\n\n\nThe confidence level is controlled by the conf_level parameter to the estimation functions. Similarly, the methods for tests and confidence interval can be modified (see ?estimate_proportion_diff).\n\nCodeconf_level &lt;- 0.90\nlyt_03 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"is_rsp\",\n    conf_level = conf_level,\n    method = \"clopper-pearson\",\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    var_labels = \"Unstratified Analysis\",\n    conf_level = conf_level,\n    method = \"ha\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    method = \"fisher\",\n    table_names = \"test_prop\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    conf_level = conf_level,\n    table_names = \"est_or\"\n  ) %&gt;%\n  estimate_multinomial_response(\n    var = \"rsp_lab\",\n    conf_level = conf_level,\n    method = \"clopper-pearson\"\n  )\n\nresult &lt;- build_table(lyt = lyt_03, df = anl)\nresult\n\n                                      A: Drug X          B: Placebo         C: Combination  \n                                       (N=134)            (N=134)              (N=132)      \n————————————————————————————————————————————————————————————————————————————————————————————\nResponders                           100 (74.6%)         84 (62.7%)           81 (61.4%)    \n90% CI (Clopper-Pearson)             (67.7, 80.7)       (55.3, 69.7)         (53.9, 68.5)   \nUnstratified Analysis                                                                       \n  Difference in Response rate (%)                          -11.9                -13.3       \n    90% CI (Anderson-Hauck)                            (-21.6, -2.3)        (-23.0, -3.5)   \n  p-value (Fisher's Exact Test)                            0.0479               0.0253      \nOdds Ratio (90% CI)                                  0.57 (0.37 - 0.89)   0.54 (0.35 - 0.84)\nComplete Response (CR)                60 (44.8%)         47 (35.1%)           57 (43.2%)    \n  90% CI (Clopper-Pearson)          (37.48, 52.25)     (28.22, 42.43)       (35.88, 50.71)  \nPartial Response (PR)                 40 (29.9%)         37 (27.6%)           24 (18.2%)    \n  90% CI (Clopper-Pearson)          (23.36, 37.02)     (21.31, 34.67)       (12.87, 24.61)  \nStable Disease (SD)                    9 (6.7%)          22 (16.4%)           13 (9.8%)     \n  90% CI (Clopper-Pearson)          (3.55, 11.43)      (11.38, 22.61)       (5.92, 15.20)   \nProgressive Disease (PD)              24 (17.9%)         16 (11.9%)           33 (25.0%)    \n  90% CI (Clopper-Pearson)          (12.67, 24.25)     (7.63, 17.57)        (18.90, 31.97)  \nNot Evaluable (NE)                     1 (0.7%)          12 (9.0%)             5 (3.8%)     \n  90% CI (Clopper-Pearson)           (0.04, 3.49)      (5.25, 14.11)         (1.50, 7.80)   \n\n\n\n\nThe stratified analysis section can be added by defining the analyses needed with control_binary_comparison for the argument strat_analysis and identifying the stratification variables to use.\n\nCodestrata &lt;- \"STRATA1\"\nlyt_04 &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  estimate_proportion(\n    vars = \"is_rsp\",\n    table_names = \"est_prop\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    var_labels = \"Unstratified Analysis\",\n    table_names = \"est_prop_diff\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    table_names = \"test_prop\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    table_names = \"est_or\"\n  ) %&gt;%\n  estimate_proportion_diff(\n    vars = \"is_rsp\",\n    show_labels = \"visible\",\n    var_labels = \"Stratified Analysis\",\n    method = \"cmh\",\n    variables = list(strata = strata),\n    table_names = \"est_prop_diff_strat\"\n  ) %&gt;%\n  test_proportion_diff(\n    vars = \"is_rsp\",\n    method = \"cmh\",\n    variables = list(strata = strata),\n    table_names = \"test_prop_strat\"\n  ) %&gt;%\n  estimate_odds_ratio(\n    vars = \"is_rsp\",\n    variables = list(strata = strata, arm = \"ARM\"),\n    table_names = \"est_or_strat\"\n  ) %&gt;%\n  estimate_multinomial_response(var = \"rsp_lab\")\n\nresult &lt;- build_table(lyt = lyt_04, df = anl)\nresult\n\n                                             A: Drug X          B: Placebo         C: Combination  \n                                              (N=134)            (N=134)              (N=132)      \n———————————————————————————————————————————————————————————————————————————————————————————————————\nResponders                                  100 (74.6%)         84 (62.7%)           81 (61.4%)    \n95% CI (Wald, with correction)              (66.9, 82.4)       (54.1, 71.2)         (52.7, 70.0)   \nUnstratified Analysis                                                                              \n  Difference in Response rate (%)                                 -11.9                -13.3       \n    95% CI (Wald, with correction)                            (-23.7, -0.2)        (-25.1, -1.4)   \n  p-value (Chi-Squared Test)                                      0.0351               0.0204      \nOdds Ratio (95% CI)                                         0.57 (0.34 - 0.96)   0.54 (0.32 - 0.91)\nStratified Analysis                                                                                \n  Difference in Response rate (%)                                 -11.9                -13.5       \n    95% CI (CMH, without correction)                          (-22.7, -1.0)        (-24.5, -2.5)   \n  p-value (Cochran-Mantel-Haenszel Test)                          0.0366               0.0180      \nOdds Ratio (95% CI)                                         0.57 (0.34 - 0.96)   0.54 (0.32 - 0.90)\nComplete Response (CR)                       60 (44.8%)         47 (35.1%)           57 (43.2%)    \n  95% CI (Wald, with correction)           (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  \nPartial Response (PR)                        40 (29.9%)         37 (27.6%)           24 (18.2%)    \n  95% CI (Wald, with correction)           (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  \nStable Disease (SD)                           9 (6.7%)          22 (16.4%)           13 (9.8%)     \n  95% CI (Wald, with correction)           (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   \nProgressive Disease (PD)                     24 (17.9%)         16 (11.9%)           33 (25.0%)    \n  95% CI (Wald, with correction)           (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  \nNot Evaluable (NE)                            1 (0.7%)          12 (9.0%)             5 (3.8%)     \n  95% CI (Wald, with correction)            (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   \n\n\n\n\nThe definition of responders is realized during the pre-processing step. The layout does not need to be modified and can be reused.\n\nCodeanl &lt;- anl_adsl %&gt;%\n  left_join(anl_adrs, by = c(\"STUDYID\", \"USUBJID\")) %&gt;%\n  mutate(rsp_lab = d_onco_rsp_label(AVALC)) %&gt;%\n  mutate(is_rsp = AVALC == \"CR\") %&gt;%\n  mutate(ARM = relevel(ARM, ref = \"A: Drug X\")) %&gt;%\n  var_relabel(ARM = \"Description of Planned Arm\")\n\nresult &lt;- build_table(lyt = lyt_01, df = anl)\nresult\n\n                                       A: Drug X          B: Placebo         C: Combination  \n                                        (N=134)            (N=134)              (N=132)      \n—————————————————————————————————————————————————————————————————————————————————————————————\nResponders                             60 (44.8%)         47 (35.1%)           57 (43.2%)    \n95% CI (Wald, with correction)        (36.0, 53.6)       (26.6, 43.5)         (34.4, 52.0)   \nUnstratified Analysis                                                                        \n  Difference in Response rate (%)                            -9.7                 -1.6       \n    95% CI (Wald, with correction)                       (-22.1, 2.7)        (-14.3, 11.1)   \n  p-value (Chi-Squared Test)                                0.1049               0.7934      \nOdds Ratio (95% CI)                                   0.67 (0.41 - 1.09)   0.94 (0.58 - 1.52)\nComplete Response (CR)                 60 (44.8%)         47 (35.1%)           57 (43.2%)    \n  95% CI (Wald, with correction)     (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  \nPartial Response (PR)                  40 (29.9%)         37 (27.6%)           24 (18.2%)    \n  95% CI (Wald, with correction)     (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  \nStable Disease (SD)                     9 (6.7%)          22 (16.4%)           13 (9.8%)     \n  95% CI (Wald, with correction)     (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   \nProgressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    \n  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  \nNot Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     \n  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   \n\n\n\n\nSimilarly to in the previous tab, redefinition or relabeling of the result is a pre-processing step and the original table layout can be reused.\n\nCodeanl &lt;- anl_adsl %&gt;%\n  left_join(anl_adrs, by = c(\"STUDYID\", \"USUBJID\")) %&gt;%\n  mutate(rsp_lab = as.character(d_onco_rsp_label(AVALC))) %&gt;%\n  mutate(\n    rsp_lab = case_when(\n      rsp_lab == \"Complete Response (CR)\" ~ \"No Progression\",\n      rsp_lab == \"Partial Response (PR)\" ~ \"No Progression\",\n      rsp_lab == \"Stable Disease (SD)\" ~ \"No Progression\",\n      TRUE ~ rsp_lab\n    )\n  ) %&gt;%\n  mutate(is_rsp = rsp_lab %in% \"No Progression\") %&gt;%\n  mutate(ARM = relevel(ARM, ref = \"A: Drug X\")) %&gt;%\n  var_relabel(ARM = \"Description of Planned Arm\")\n\nresult &lt;- build_table(lyt = lyt_01, df = anl)\nresult\n\n                                       A: Drug X          B: Placebo         C: Combination  \n                                        (N=134)            (N=134)              (N=132)      \n—————————————————————————————————————————————————————————————————————————————————————————————\nResponders                            109 (81.3%)        106 (79.1%)           94 (71.2%)    \n95% CI (Wald, with correction)        (74.4, 88.3)       (71.8, 86.4)         (63.1, 79.3)   \nUnstratified Analysis                                                                        \n  Difference in Response rate (%)                            -2.2                -10.1       \n    95% CI (Wald, with correction)                       (-12.5, 8.0)         (-21.0, 0.8)   \n  p-value (Chi-Squared Test)                                0.6455               0.0520      \nOdds Ratio (95% CI)                                   0.87 (0.48 - 1.59)   0.57 (0.32 - 1.01)\nProgressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    \n  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  \nNo Progression                        109 (81.3%)        106 (79.1%)           94 (71.2%)    \n  95% CI (Wald, with correction)     (74.37, 88.31)     (71.85, 86.36)       (63.11, 79.31)  \nNot Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     \n  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nADSL &lt;- df_explicit_na(ADSL)\nADRS &lt;- df_explicit_na(ADRS)\n\nADSL &lt;- ADSL %&gt;%\n  mutate(Dum_ARM = factor(rep(\"Single ARM\", nrow(.))))\nADRS &lt;- ADRS %&gt;%\n  mutate(Dum_ARM = factor(rep(\"Single ARM\", nrow(.))))\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\n      dataname = \"ADSL\",\n      x = ADSL,\n      code =\n        'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\")) %&gt;%\n           mutate(Dum_ARM = factor(rep(\"Single ARM\", nrow(.))))'\n    ),\n    cdisc_dataset(\n      dataname = \"ADRS\",\n      x = ADRS,\n      code =\n        'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adrs\")) %&gt;%\n          mutate(Dum_ARM = factor(rep(\"Single ARM\", nrow(.))))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_binary_outcome(\n      label = \"Responders\",\n      dataname = \"ADRS\",\n      paramcd = choices_selected(\n        choices = value_choices(ADRS, \"PARAMCD\", \"PARAM\"),\n        selected = \"BESRSPI\"\n      ),\n      arm_var = choices_selected(\n        choices = variable_choices(ADRS, c(\"ARM\", \"ARMCD\", \"ACTARMCD\", \"Dum_ARM\")),\n        selected = \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      strata_var = choices_selected(\n        choices = variable_choices(ADRS, c(\"SEX\", \"BMRKR2\")),\n        select = NULL\n      ),\n      rsp_table = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:56:25.5008 pid:7162 token:[] teal.modules.clinical Initializing tm_t_binary_outcome\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/coxt01.html",
+    "href": "tables/efficacy/coxt01.html",
+    "title": "COXT01",
+    "section": "",
+    "text": "Cox models are the most commonly used methods to estimate the magnitude of the effect in survival analyses. It assumes proportional hazards; that is, it assumes that the ratio of the hazards of the two groups (e.g. two arms) is constant over time. This ratio is referred to as the “hazard ratio” and is one of the most commonly reported metrics to describe the effect size in survival analysis.\n\n\nData Setup\nCox Regression\nCox Regression  with Interaction Term\nCox Regression  Specifying Covariates\nCox Regression Setting  Strata, Ties, Alpha Level\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadtte &lt;- df_explicit_na(adtte)\n\nadsl_filtered &lt;- adsl %&gt;% dplyr::filter(\n  RACE %in% c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\", \"WHITE\")\n)\nadtte_filtered &lt;- dplyr::inner_join(\n  x = adsl_filtered[, c(\"STUDYID\", \"USUBJID\")],\n  y = adtte,\n  by = c(\"STUDYID\", \"USUBJID\")\n)\n\nanl &lt;- adtte_filtered %&gt;%\n  filter(PARAMCD == \"OS\") %&gt;%\n  mutate(EVENT = 1 - CNSR) %&gt;%\n  filter(ARM %in% c(\"B: Placebo\", \"A: Drug X\")) %&gt;%\n  mutate(ARM = droplevels(relevel(ARM, \"B: Placebo\"))) %&gt;%\n  mutate(RACE = droplevels(RACE) %&gt;% formatters::with_label(\"Race\"))\n\n# Add variable for column split label\nanl &lt;- anl %&gt;% mutate(col_label = \"Treatment Effect Adjusted for Covariate\")\n\n\n\n\nThe summarize_coxreg function fits, tidies and arranges a Cox regression model in a table layout using the rtables framework. For a Cox regression model, arguments variables, control, and at can be specified (see ?summarize_coxreg for more details and customization options). All variables specified within variables must be present in the data used when building the table.\nTo see the same model as a data.frame object, these three arguments (as well as the data) can be passed to the fit_coxreg_univar function, and the resulting list tidied using broom::tidy().\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARM\",\n  covariates = c(\"AGE\", \"SEX\", \"RACE\")\n)\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"col_label\") %&gt;%\n  summarize_coxreg(variables = variables) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model       Treatment Effect Adjusted for Covariate     \n                                           n     Hazard Ratio       95% CI       p-value \n—————————————————————————————————————————————————————————————————————————————————————————\nTreatment:                                                                               \n  A: Drug X vs control (B: Placebo)       247        0.97        (0.66, 1.43)     0.8934 \nCovariate:                                                                               \n  Age                                     247        0.95        (0.65, 1.40)     0.7948 \n  Sex                                     247        0.98        (0.67, 1.43)     0.8970 \n  Race                                    247        0.98        (0.67, 1.44)     0.9239 \n\n\n\n\nThe argument control can be used to modify standard outputs; control_coxreg() helps in adopting the right settings (see ?control_coxreg). For instance, control is used to include the interaction terms.\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARM\",\n  covariates = c(\"AGE\", \"RACE\")\n)\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"col_label\") %&gt;%\n  summarize_coxreg(\n    variables = variables,\n    control = control_coxreg(interaction = TRUE),\n    .stats = c(\"n\", \"hr\", \"ci\", \"pval\", \"pval_inter\")\n  ) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             \n                                          n    Hazard Ratio      95% CI      p-value   Interaction p-value\n——————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment:                                                                                                \n  A: Drug X vs control (B: Placebo)      247       0.97       (0.66, 1.43)   0.8934                       \nCovariate:                                                                                                \n  Age                                    247                                                 0.7878       \n    34                                             0.95       (0.65, 1.40)                                \n  Race                                   247                                                 0.6850       \n    ASIAN                                          1.05       (0.63, 1.75)                                \n    BLACK OR AFRICAN AMERICAN                      1.08       (0.51, 2.29)                                \n    WHITE                                          0.67       (0.27, 1.71)                                \n\n\n\n\nThe optional argument at allows the user to provide the expected level of estimation for the interaction when the predictor is a quantitative variable. For instance, it might be relevant to choose the age at which the hazard ratio should be estimated. If no input is provided to at, the median value is used in the row name (as in the previous tab).\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARM\",\n  covariates = c(\"AGE\", \"SEX\")\n)\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"col_label\") %&gt;%\n  summarize_coxreg(\n    variables = variables,\n    control = control_coxreg(interaction = TRUE),\n    at = list(AGE = c(30, 40, 50)),\n    .stats = c(\"n\", \"hr\", \"ci\", \"pval\", \"pval_inter\")\n  ) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             \n                                          n    Hazard Ratio      95% CI      p-value   Interaction p-value\n——————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment:                                                                                                \n  A: Drug X vs control (B: Placebo)      247       0.97       (0.66, 1.43)   0.8934                       \nCovariate:                                                                                                \n  Age                                    247                                                 0.7878       \n    30                                             0.98       (0.63, 1.51)                                \n    40                                             0.91       (0.54, 1.51)                                \n    50                                             0.84       (0.32, 2.20)                                \n  Sex                                    247                                                 0.1455       \n    F                                              0.77       (0.47, 1.27)                                \n    M                                              1.38       (0.75, 2.52)                                \n\n\n\n\nAdditional controls can be customized using control_coxreg (see ?control_coxreg) such as the ties calculation method and the confidence level. Stratification variables can be added via the strata element of the variables list.\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARM\",\n  covariates = c(\"AGE\", \"RACE\"),\n  strata = \"SEX\"\n)\n\ncontrol &lt;- control_coxreg(\n  ties = \"breslow\",\n  interaction = TRUE,\n  conf_level = 0.90\n)\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"col_label\") %&gt;%\n  summarize_coxreg(\n    variables = variables,\n    control = control,\n    at = list(AGE = c(30, 40, 50)),\n    .stats = c(\"n\", \"hr\", \"ci\", \"pval\", \"pval_inter\")\n  ) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             \n                                          n    Hazard Ratio      90% CI      p-value   Interaction p-value\n——————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment:                                                                                                \n  A: Drug X vs control (B: Placebo)      247       0.98       (0.71, 1.35)   0.9063                       \nCovariate:                                                                                                \n  Age                                    247                                                 0.7733       \n    30                                             0.98       (0.68, 1.42)                                \n    40                                             0.91       (0.59, 1.39)                                \n    50                                             0.84       (0.38, 1.87)                                \n  Race                                   247                                                 0.6501       \n    ASIAN                                          1.07       (0.64, 1.77)                                \n    BLACK OR AFRICAN AMERICAN                      1.08       (0.51, 2.29)                                \n    WHITE                                          0.66       (0.26, 1.67)                                \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadtte &lt;- df_explicit_na(adtte)\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADTTE\", adtte, code = 'adtte &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adtte\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_coxreg(\n      label = \"Cox Reg.\",\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\", \"ACTARMCD\"), \"ARM\"),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adtte, \"PARAMCD\", \"PARAM\"), \"OS\"\n      ),\n      strata_var = choices_selected(\n        c(\"SEX\", \"STRATA1\", \"STRATA2\"), NULL\n      ),\n      cov_var = choices_selected(\n        c(\"AGE\", \"SEX\", \"RACE\"), \"AGE\"\n      ),\n      multivariate = FALSE\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:55:29.2419 pid:7012 token:[] teal.modules.clinical Initializing tm_t_coxreg\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          \n[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        \n[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    \n[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        \n[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          \n[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       \n[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         \n[43] stringr_1.5.0         splines_4.3.1         assertthat_0.2.1     \n[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[49] sandwich_3.0-2        jsonlite_1.8.7        carData_3.0-5        \n[52] callr_3.7.3           car_3.1-2             teal.widgets_0.4.0   \n[55] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      \n[58] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             \n[61] codetools_0.2-19      stringi_1.7.12        gtable_0.3.4         \n[64] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[67] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[70] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[73] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[76] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[79] broom_1.0.5           teal.reporter_0.2.1   bslib_0.5.1          \n[82] httpuv_1.6.11         Rcpp_1.0.11           coda_0.19-4          \n[85] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[88] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "repro.html#reproducibility",
+    "href": "repro.html#reproducibility",
+    "title": "",
+    "section": "Reproducibility",
+    "text": "Reproducibility\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nloaded via a namespace (and not attached):\n [1] htmlwidgets_1.6.2 compiler_4.3.1    fastmap_1.1.1     cli_3.6.1        \n [5] tools_4.3.1       htmltools_0.5.6   rstudioapi_0.15.0 yaml_2.3.7       \n [9] rmarkdown_2.25    knitr_1.44        jsonlite_1.8.7    xfun_0.40        \n[13] digest_0.6.33     rlang_1.1.1       evaluate_0.21    \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/mng01.html",
+    "href": "graphs/other/mng01.html",
+    "title": "MNG01",
+    "section": "",
+    "text": "Data Setup\nPlot of Mean  and CI\nPlot of Mean and CIs of Change  from Baseline (Changing the Input  Analysis Data Set and Analysis Variable)\nPlot of Mean (+/-SD)  (Changing the Statistics)\nPlot of Mean and CI  (Modify Alpha Level)\nPlot of Mean and CI (with Number  of Patients only in Table Section)\nPlot of Mean and CI  (with Table Section)\nPlot of Median and CI (Visits  Condensed in Table Section)\nPlot of Mean and  Upper Confidence Limit\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(nestcolor)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\n\nadsl_f &lt;- adsl %&gt;%\n  filter(SAFFL == \"Y\") %&gt;%\n  df_explicit_na()\n\nadlb_f &lt;- adlb %&gt;%\n  mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min)) %&gt;%\n  dplyr::filter(\n    SAFFL == \"Y\",\n    ANL01FL == \"Y\",\n    ONTRTFL == \"Y\",\n    PARAMCD == \"ALT\",\n    AVISIT != \"SCREENING\"\n  ) %&gt;%\n  droplevels() %&gt;%\n  df_explicit_na()\n\nadvs_f &lt;- advs %&gt;%\n  mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min)) %&gt;%\n  dplyr::filter(\n    SAFFL == \"Y\",\n    ONTRTFL == \"Y\",\n    PARAMCD == \"DIABP\",\n    AVISIT != \"SCREENING\"\n  ) %&gt;%\n  droplevels() %&gt;%\n  df_explicit_na()\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = advs_f,\n  alt_counts_df = adsl_f,\n  variables = control_lineplot_vars(y = \"CHG\"),\n  title = \"Plot of Mean and 95% Confidence Intervals of Change from Baseline by Visit\",\n  subtitle = \"Assessment:\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  interval = \"mean_sdi\",\n  whiskers = c(\"mean_sdi_lwr\", \"mean_sdi_upr\"),\n  title = \"Plot of Mean (+/-SD)\",\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  control = control_analyze_vars(conf_level = 0.80),\n  title = \"Plot of Mean and 80% Confidence Limits by Visit\",\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  table = \"n\",\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  table = c(\"n\", \"mean\", \"mean_ci\"),\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\nThis option is not supported.\n\n\n\nCodeplot &lt;- g_lineplot(\n  df = adlb_f,\n  alt_counts_df = adsl_f,\n  whiskers = \"mean_ci_upr\",\n  subtitle = \"Laboratory Test:\"\n)\nplot\n\n\n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", ADLB, code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n                    mutate(AVISIT = forcats::fct_reorder(AVISIT, AVISITN, min))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_g_lineplot(\n      label = \"LINE PLOT\",\n      dataname = \"ADLB\",\n      strata = choices_selected(\n        variable_choices(ADSL, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      y = choices_selected(\n        variable_choices(ADLB, c(\"AVAL\", \"BASE\", \"CHG\", \"PCHG\")),\n        \"AVAL\"\n      ),\n      param = choices_selected(\n        value_choices(ADLB, \"PARAMCD\", \"PARAM\"),\n        \"ALT\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:54:18.9714 pid:6758 token:[] teal.modules.clinical Initializing tm_g_lineplot\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        \n [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        \n [7] digest_0.6.33         estimability_1.4.1    mime_0.12            \n[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       \n[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       \n[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          \n[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           \n[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      \n[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   \n[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[34] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[37] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[40] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[43] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[49] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[52] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[55] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[58] ps_1.7.5              codetools_0.2-19      cowplot_1.1.1        \n[61] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[64] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[67] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[70] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[73] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[76] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[79] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          \n[82] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[85] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[88] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/cig01.html",
+    "href": "graphs/other/cig01.html",
+    "title": "CIG01",
+    "section": "",
+    "text": "Data Setup\nPlot of Mean and  95% CIs for Mean\nPlot of Confidence Interval Using  a Different Stratification Variable\nPlot of Median and  95% CIs for Median\nPlot of Median and 95% CIs for  Median Using Different Alpha Level\nTable of Mean  and Median\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(ggplot2)\nlibrary(dplyr)\nlibrary(scda)\nlibrary(nestcolor)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  filter(PARAMCD == \"ALT\", AVISIT == \"BASELINE\")\n\n\n\n\nThe function stat_mean_ci from the tern package can be used with default values to draw the 95% confidence interval around the mean.\n\nCodeplot &lt;- ggplot(\n  data = adlb,\n  mapping = aes(\n    x = ARMCD, y = AVAL, color = SEX,\n    lty = SEX, shape = SEX\n  )\n) +\n  stat_summary(\n    fun.data = tern::stat_mean_ci,\n    geom = \"errorbar\",\n    width = 0.1,\n    position = position_dodge(width = 0.5)\n  ) +\n  stat_summary(\n    fun = mean,\n    geom = \"point\",\n    position = position_dodge(width = 0.5)\n  ) +\n  labs(\n    title = \"Confidence Interval Plot by Treatment Group\",\n    caption = \"Mean and 95% CIs for mean are displayed.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  )\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- ggplot(\n  data = adlb,\n  mapping = aes(\n    x = ARMCD, y = AVAL, color = STRATA2,\n    lty = STRATA2, shape = STRATA2\n  )\n) +\n  stat_summary(\n    fun.data = tern::stat_mean_ci,\n    geom = \"errorbar\",\n    width = 0.1,\n    position = position_dodge(width = 0.5)\n  ) +\n  stat_summary(\n    fun = mean,\n    geom = \"point\",\n    position = position_dodge(width = 0.5)\n  ) +\n  labs(\n    title = \"Confidence Interval Plot by Treatment Group\",\n    caption = \"Mean and 95% CIs for mean are displayed.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  )\nplot\n\n\n\n\n\n\nThe function stat_median_ci from the tern package works similarly to stat_mean_ci.\n\nCodeplot &lt;- ggplot(\n  data = adlb,\n  mapping = aes(\n    x = ARMCD, y = AVAL, color = STRATA1,\n    lty = STRATA1, shape = STRATA1\n  )\n) +\n  stat_summary(\n    fun.data = stat_median_ci,\n    geom = \"errorbar\",\n    width = 0.1,\n    position = position_dodge(width = 0.5)\n  ) +\n  stat_summary(\n    fun = median,\n    geom = \"point\",\n    position = position_dodge(width = 0.5)\n  ) +\n  labs(\n    title = \"Confidence Interval Plot by Treatment Group\",\n    caption = \"Median and 95% CIs for median are displayed.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  )\n\n\n\n\nTo modify the confidence level for the estimation of the confidence interval, the call to stat_mean_ci (or stat_median_ci) can be slightly modified.\n\nCodeplot &lt;- ggplot(\n  data = adlb,\n  mapping = aes(\n    x = ARMCD, y = AVAL, color = SEX,\n    lty = SEX, shape = SEX\n  )\n) +\n  stat_summary(\n    fun.data = function(x) tern::stat_mean_ci(x, conf_level = 0.9),\n    geom = \"errorbar\",\n    width = 0.1,\n    position = position_dodge(width = 0.5)\n  ) +\n  stat_summary(\n    fun = mean,\n    geom = \"point\",\n    position = position_dodge(width = 0.5)\n  ) +\n  labs(\n    title = \"Confidence Interval Plot by Treatment Group\",\n    caption = \"Mean and 90% CIs for mean are displayed.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  )\n\n\n\n\nThe corresponding table is simply obtained using the rtables framework:\n\nCodelyt &lt;- basic_table() %&gt;%\n  split_cols_by(var = \"ARMCD\") %&gt;%\n  analyze_vars(vars = \"AVAL\", .stats = c(\"mean_sd\", \"median\"))\ntable &lt;- build_table(lyt = lyt, df = adlb)\ntable\n\n              ARM A        ARM B        ARM C   \n————————————————————————————————————————————————\nMean (SD)   17.7 (9.9)   18.7 (9.8)   19.5 (9.1)\nMedian         17.5         18.2         19.0   \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL),\n    cdisc_dataset(\"ADLB\", ADLB),\n    code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")'\n  ),\n  modules = modules(\n    tm_g_ci(\n      label = \"Confidence Interval Plot\",\n      x_var = data_extract_spec(\n        dataname = \"ADSL\",\n        select = select_spec(\n          choices = c(\"ARMCD\", \"BMRKR2\"),\n          selected = c(\"ARMCD\"),\n          multiple = FALSE,\n          fixed = FALSE\n        )\n      ),\n      y_var = data_extract_spec(\n        dataname = \"ADLB\",\n        filter = list(\n          filter_spec(\n            vars = \"PARAMCD\",\n            choices = levels(ADLB$PARAMCD),\n            selected = levels(ADLB$PARAMCD)[1],\n            multiple = FALSE,\n            label = \"Select lab:\"\n          ),\n          filter_spec(\n            vars = \"AVISIT\",\n            choices = levels(ADLB$AVISIT),\n            selected = levels(ADLB$AVISIT)[1],\n            multiple = FALSE,\n            label = \"Select visit:\"\n          )\n        ),\n        select = select_spec(\n          label = \"Analyzed Value\",\n          choices = c(\"AVAL\", \"CHG\"),\n          selected = \"AVAL\",\n          multiple = FALSE,\n          fixed = FALSE\n        )\n      ),\n      color = data_extract_spec(\n        dataname = \"ADSL\",\n        select = select_spec(\n          label = \"Color by variable\",\n          choices = c(\"SEX\", \"STRATA1\", \"STRATA2\"),\n          selected = c(\"STRATA1\"),\n          multiple = FALSE,\n          fixed = FALSE\n        )\n      )\n    )\n  ),\n  header = \"Example of Confidence Interval Plot\",\n  footer = tags$p(\n    class = \"text-muted\", \"Source: `teal.modules.clinical::tm_g_ci`\"\n  )\n)\n\n[INFO] 2023-09-25 10:53:06.4337 pid:6516 token:[] teal.modules.clinical Initializing tm_g_ci\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              scda_0.1.6                  \n [9] dplyr_1.1.3                  ggplot2_3.4.3               \n[11] tern_0.9.0                   rtables_0.6.3               \n[13] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        \n [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        \n [7] digest_0.6.33         estimability_1.4.1    mime_0.12            \n[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       \n[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       \n[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          \n[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           \n[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      \n[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   \n[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          \n[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       \n[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         \n[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          \n[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       \n[49] jsonlite_1.8.7        callr_3.7.3           teal.widgets_0.4.0   \n[52] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      \n[55] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             \n[58] codetools_0.2-19      gtable_0.3.4          later_1.3.1          \n[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         \n[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      \n[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           \n[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/bwg01.html",
+    "href": "graphs/other/bwg01.html",
+    "title": "BWG01",
+    "section": "",
+    "text": "Data Setup\nStandard Plot\nPlot Changing  Whiskers\nPlot Adding  Outliers\nPlot Specifying Marker  for Outliers and  Adding Patient ID\nPlot Specifying  Marker for Mean\nPlot by Treatment  and Timepoint\nPlot by Timepoint  and Treatment\nPlot with  Table Section\nPlot with Number of Patients  only in Table Section\nteal App\nReproducibility\n\n\n\n\nCode# generic code for all plots\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\nadlb &lt;- adlb %&gt;% filter(PARAMCD == \"ALT\" & AVISIT == \"WEEK 2 DAY 15\")\n\n# Definition of boxplot boundaries and whiskers\nfive_num &lt;- function(x, probs = c(0, 0.25, 0.5, 0.75, 1)) {\n  r &lt;- quantile(x, probs)\n  names(r) &lt;- c(\"ymin\", \"lower\", \"middle\", \"upper\", \"ymax\")\n  r\n}\n\n# get outliers based on quantile\n# for outliers based on IQR see coef in geom_boxplot\nget_outliers &lt;- function(x, probs = c(0.05, 0.95)) {\n  r &lt;- subset(x, x &lt; quantile(x, probs[1]) | quantile(x, probs[2]) &lt; x)\n  if (!is.null(x)) {\n    x_names &lt;- subset(names(x), x &lt; quantile(x, probs[1]) | quantile(x, probs[2]) &lt; x)\n    names(r) &lt;- x_names\n  }\n  r\n}\n\n# create theme used for all plots\ntheme_bp &lt;- theme(\n  plot.title = element_text(hjust = 0),\n  plot.subtitle = element_text(hjust = 0),\n  plot.caption = element_text(hjust = 0),\n  panel.background = element_rect(fill = \"white\", color = \"grey50\")\n)\n\n# assign fill color and outline color\nfc &lt;- \"#eaeef5\"\noc &lt;- getOption(\"ggplot2.discrete.fill\")[1]\n\n# get plot metadata data to derive coordinates for adding annotations\nbp_annos &lt;- function(bp, color, annos = 1) {\n  bp_mdat &lt;- ggplot_build(bp)$data[[1]]\n  # bp_metadata &lt;&lt;- bp_mdat\n  if (annos == 1) {\n    bp &lt;- bp +\n      geom_segment(data = bp_mdat, aes(\n        x = xmin + (xmax - xmin) / 4, xend = xmax - (xmax - xmin) / 4,\n        y = ymax, yend = ymax\n      ), size = .5, color = color) +\n      geom_segment(data = bp_mdat, aes(\n        x = xmin + (xmax - xmin) / 4, xend = xmax - (xmax - xmin) / 4,\n        y = ymin, yend = ymin\n      ), size = .5, color = color)\n  } else {\n    bp &lt;- bp +\n      geom_segment(data = bp_mdat, aes(\n        x = xmin + (xmax - xmin) / 4, xend = xmax - (xmax - xmin) / 4,\n        y = ymax, yend = ymax\n      ), size = .5, color = color) +\n      geom_segment(data = bp_mdat, aes(\n        x = xmin + (xmax - xmin) / 4, xend = xmax - (xmax - xmin) / 4,\n        y = ymin, yend = ymin\n      ), size = .5, color = color) +\n      geom_segment(data = bp_mdat, aes(\n        x = xmin, xend = xmax,\n        y = middle, yend = middle\n      ), colour = color, size = .5)\n  }\n  return(bp)\n}\n\n\n\n\n\nCodebp_1 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(geom = \"boxplot\", fun.data = five_num, fill = fc, color = oc) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 8) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    caption = \"The whiskers extend to the minimum and maximum values.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_1, oc)\n\nWarning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.\nℹ Please use `linewidth` instead.\n\nCodeplot\n\n\n\n\n\n\n\nCodebp_3 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(\n    geom = \"boxplot\", fun.data = five_num,\n    fun.args = list(probs = c(0.05, 0.25, 0.5, 0.75, 0.95)), fill = fc, color = oc\n  ) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 8) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    caption = \"The whiskers extend to the 5th and 95th percentile. Values outside the whiskers have not been plotted.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_3, oc)\nplot\n\n\n\n\n\n\n\nCodebp_4 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(\n    geom = \"boxplot\", fun.data = five_num,\n    fun.args = list(probs = c(0.05, 0.25, 0.5, 0.75, 0.95)), fill = fc, color = oc\n  ) +\n  stat_summary(geom = \"point\", fun = get_outliers, shape = 1) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 8) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    caption = \"The whiskers extend to the 5th and 95th percentile.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_4, oc)\nplot\n\n\n\n\n\n\n\nCodeadlb_o &lt;- adlb %&gt;%\n  group_by(ARMCD) %&gt;%\n  mutate(OUTLIER = AVAL &lt; quantile(AVAL, 0.01) | AVAL &gt; quantile(AVAL, 0.99)) %&gt;%\n  filter(OUTLIER == TRUE) %&gt;%\n  select(ARMCD, AVAL, USUBJID)\n# Next step may be study-specific: shorten USUBJID to make annotation labels\n# next 2 lines of code split USUBJID by \"-\" and take the last syllable as ID\nn_split &lt;- max(vapply(strsplit(adlb_o$USUBJID, \"-\"), length, numeric(1)))\nadlb_o$ID &lt;- vapply(strsplit(adlb_o$USUBJID, \"-\"), `[[`, n_split, FUN.VALUE = \"a\")\n\nbp_5 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(\n    geom = \"boxplot\", fun.data = five_num,\n    fun.args = list(probs = c(0.01, 0.25, 0.5, 0.75, 0.99)), fill = fc, color = oc\n  ) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 8) +\n  geom_point(data = adlb_o, aes(x = ARMCD, y = AVAL), shape = 1) +\n  geom_text(data = adlb_o, aes(x = ARMCD, y = AVAL, label = ID), size = 3, hjust = -0.2) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    caption = \"The whiskers extend to the largest and smallest observed value within 1.5*IQR.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_5, oc)\nplot\n\n\n\n\n\n\n\nCodebp_6 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  geom_boxplot(fill = fc, color = oc) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 5) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    caption = \"The whiskers extend to the minimum and maximum values.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_6, oc)\nplot\n\n\n\n\n\n\n\nCodeadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_v &lt;- adlb %&gt;%\n  filter(PARAMCD == \"ALT\" &\n    AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\", \"WEEK 4 DAY 29\"))\n\nbp_7 &lt;- ggplot(adlb_v, aes(x = AVISIT, y = AVAL)) +\n  stat_summary(geom = \"boxplot\", fun.data = five_num, position = position_dodge2(.5), aes(fill = ARMCD, color = ARMCD)) +\n  stat_summary(geom = \"point\", fun = mean, aes(group = ARMCD), size = 3, shape = 8, position = position_dodge2(1)) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    caption = \"The whiskers extend to the minimum and maximum values.\",\n    x = \"Visit\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_7, oc, 2)\nplot\n\n\n\n\n\n\n\nCodebp_8 &lt;- ggplot(adlb_v, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(geom = \"boxplot\", fun.data = five_num, position = position_dodge2(width = .5), aes(fill = AVISIT, color = AVISIT)) +\n  stat_summary(geom = \"point\", fun = mean, aes(group = AVISIT), size = 3, shape = 8, position = position_dodge2(1)) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    caption = \"The whiskers extend to the minimum and maximum values.\",\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\nplot &lt;- bp_annos(bp_8, oc, 2)\nplot\n\n\n\n\n\n\n\nCode# Make wide dataset with summary statistics\nadlb_wide &lt;- adlb %&gt;%\n  group_by(ARMCD) %&gt;%\n  summarise(\n    n = n(),\n    mean = round(mean(AVAL), 1),\n    median = round(median(AVAL), 1),\n    median_ci = paste(round(DescTools::MedianCI(AVAL)[1:2], 1), collapse = \" - \"),\n    q1_q3 = paste(round(quantile(AVAL, c(0.25, 0.75)), 1), collapse = \" - \"),\n    min_max = paste0(round(min(AVAL), 1), \"-\", max(round(AVAL, 2)))\n  )\n\n# Make long dataset\nadlb_long &lt;- tidyr::gather(adlb_wide, key = type, value = stat, n:min_max)\nadlb_long &lt;- adlb_long %&gt;% mutate(\n  type_lbl = case_when(\n    type == \"n\" ~ \"n\",\n    type == \"mean\" ~ \"Mean\",\n    type == \"median\" ~ \"Median\",\n    type == \"median_ci\" ~ \"95% CI for Median\",\n    type == \"q1_q3\" ~ \"25% and 75%-ile\",\n    type == \"min_max\" ~ \"Min - Max\"\n  )\n)\nadlb_long$type_lbl &lt;- factor(adlb_long$type_lbl,\n  levels = c(\"Min - Max\", \"25% and 75%-ile\", \"95% CI for Median\", \"Median\", \"Mean\", \"n\")\n)\n\nbp_9 &lt;- ggplot(adlb, aes(x = ARMCD, y = AVAL)) +\n  stat_summary(geom = \"boxplot\", fun.data = five_num, fill = fc, color = oc) +\n  stat_summary(geom = \"point\", fun = mean, size = 3, shape = 8) +\n  labs(\n    title = \"Box Plot of Laboratory Test Results\",\n    subtitle = paste(\"Visit:\", adlb$AVISIT[1]),\n    x = \"Treatment Group\",\n    y = paste0(adlb$PARAMCD[1], \" (\", adlb$AVALU[1], \")\")\n  ) +\n  theme_bp\n\ntbl_theme &lt;- theme(\n  panel.border = element_blank(),\n  panel.grid.major = element_blank(),\n  panel.grid.minor = element_blank(),\n  axis.ticks = element_blank(),\n  axis.title = element_blank(),\n  axis.text.y = element_text(face = \"plain\"),\n  axis.text.x = element_blank()\n)\n\ntbl_1 &lt;- ggplot(adlb_long, aes(x = ARMCD, y = type_lbl, label = stat), vjust = 10) +\n  geom_text(size = 3) +\n  scale_y_discrete(labels = levels(adlb_long$type_lbl)) +\n  theme_bw() +\n  tbl_theme +\n  labs(caption = \"The whiskers extend to the minimum and maximum values.\") +\n  theme_bp\n\nplot &lt;- ggpubr::ggarrange(bp_annos(bp_9, oc), tbl_1,\n  heights = c(4, 2),\n  ncol = 1, nrow = 2, align = \"v\"\n)\nplot\n\n\n\n\n\n\n\nCodetbl_2 &lt;- adlb_long %&gt;%\n  filter(type == \"n\") %&gt;%\n  ggplot(aes(x = ARMCD, y = type_lbl, label = stat)) +\n  geom_text(size = 3) +\n  scale_y_discrete(labels = \"n\") +\n  theme_bw() +\n  tbl_theme +\n  labs(caption = \"The whiskers extend to the minimum and maximum values.\") +\n  theme_bp\n\nplot &lt;- ggpubr::ggarrange(bp_annos(bp_9, oc), tbl_2,\n  heights = c(6, 1),\n  ncol = 1, nrow = 2, align = \"v\"\n)\nplot\n\n\n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.general)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# If PARAMCD and AVISIT are not factors, convert to factors\n# Also fill in missing values with \"&lt;Missing&gt;\"\nADLB &lt;- ADLB %&gt;%\n  tern::df_explicit_na(\n    omit_columns = setdiff(names(ADLB), c(\"PARAMCD\", \"AVISIT\")),\n    char_as_factor = TRUE\n  )\n\n# If statment below fails, pre-process ADLB to be one record per\n# study, subject, param and visit eg. filter with ANLFL = 'Y'\nstopifnot(nrow(ADLB) == nrow(unique(ADLB[, c(\"STUDYID\", \"USUBJID\", \"PARAMCD\", \"AVISIT\")])))\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL),\n    cdisc_dataset(\"ADLB\", ADLB, keys = c(\"STUDYID\", \"USUBJID\", \"PARAMCD\", \"AVISIT\")), # do not modify\n    code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n    ADLB &lt;- ADLB %&gt;%\n      tern::df_explicit_na(\n        omit_columns = setdiff(names(ADLB), c(\"PARAMCD\", \"AVISIT\")),\n        char_as_factor = TRUE)'\n  ),\n  modules = modules(\n    tm_g_bivariate(\n      x = data_extract_spec(\n        dataname = \"ADSL\",\n        select = select_spec(\n          label = \"Select variable:\",\n          choices = names(ADSL),\n          selected = \"ARMCD\",\n          fixed = FALSE\n        )\n      ),\n      y = data_extract_spec(\n        dataname = \"ADLB\",\n        filter = list(\n          filter_spec(\n            vars = c(\"PARAMCD\"),\n            choices = levels(ADLB$PARAMCD),\n            selected = levels(ADLB$PARAMCD)[1],\n            multiple = FALSE,\n            label = \"Choose lab parameter\"\n          ),\n          filter_spec(\n            vars = c(\"AVISIT\"),\n            choices = levels(ADLB$AVISIT),\n            selected = levels(ADLB$AVISIT)[1],\n            multiple = FALSE,\n            label = \"Choose visit\"\n          )\n        ),\n        select = select_spec(\n          label = \"Select variable:\",\n          choices = names(ADLB),\n          selected = \"AVAL\",\n          multiple = FALSE,\n          fixed = TRUE\n        )\n      ),\n      row_facet = data_extract_spec(\n        dataname = \"ADLB\",\n        select = select_spec(\n          label = \"Select variables:\",\n          choices = names(ADLB),\n          selected = NULL,\n          multiple = FALSE,\n          fixed = FALSE\n        )\n      ),\n      col_facet = data_extract_spec(\n        dataname = \"ADLB\",\n        select = select_spec(\n          label = \"Select variables:\",\n          choices = names(ADLB),\n          selected = NULL,\n          multiple = FALSE,\n          fixed = FALSE\n        )\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:52:18.1727 pid:6308 token:[] teal.modules.general Initializing tm_g_bivariate\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.general_0.2.16 teal_0.14.0                \n [3] teal.transform_0.4.0        magrittr_2.0.3             \n [5] teal.slice_0.4.0            teal.data_0.3.0            \n [7] shinyTree_0.3.1             shiny_1.7.5                \n [9] ggmosaic_0.3.3              nestcolor_0.1.2            \n[11] ggplot2_3.4.3               dplyr_1.1.3                \n[13] scda_0.1.6                 \n\nloaded via a namespace (and not attached):\n  [1] Rdpack_2.5            gld_2.6.6             logger_0.2.2         \n  [4] testthat_3.1.10       readxl_1.4.3          rlang_1.1.1          \n  [7] e1071_1.7-13          compiler_4.3.1        callr_3.7.3          \n [10] vctrs_0.6.3           formatters_0.5.2      stringr_1.5.0        \n [13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      \n [16] ellipsis_0.3.2        fontawesome_0.5.2     labeling_0.4.3       \n [19] utf8_1.2.3            promises_1.2.1        rmarkdown_2.25       \n [22] ps_1.7.5              purrr_1.0.2           xfun_0.40            \n [25] cachem_1.0.8          teal.reporter_0.2.1   jsonlite_1.8.7       \n [28] later_1.3.1           broom_1.0.5           DescTools_0.99.50    \n [31] R6_2.5.1              bslib_0.5.1           stringi_1.7.12       \n [34] car_3.1-2             boot_1.3-28.1         jquerylib_0.1.4      \n [37] brio_1.1.3            cellranger_1.1.0      Rcpp_1.0.11          \n [40] rtables_0.6.3         knitr_1.44            teal.logger_0.1.3    \n [43] httpuv_1.6.11         Matrix_1.6-1.1        splines_4.3.1        \n [46] tidyselect_1.2.0      rstudioapi_0.15.0     abind_1.4-5          \n [49] yaml_2.3.7            codetools_0.2-19      processx_3.8.2       \n [52] teal.widgets_0.4.0    lattice_0.21-8        tibble_3.2.1         \n [55] withr_2.5.0           evaluate_0.21         survival_3.5-7       \n [58] proxy_0.4-27          shinycssloaders_1.0.0 pillar_1.9.0         \n [61] ggpubr_0.6.0          carData_3.0-5         checkmate_2.2.0      \n [64] shinyjs_2.1.0         plotly_4.10.2         generics_0.1.3       \n [67] munsell_0.5.0         scales_1.2.1          rootSolve_1.8.2.4    \n [70] xtable_1.8-4          class_7.3-22          glue_1.6.2           \n [73] lmom_3.0              lazyeval_0.2.2        tools_4.3.1          \n [76] data.table_1.14.8     webshot_0.5.5         ggsignif_0.6.4       \n [79] forcats_1.0.0         Exact_3.2             mvtnorm_1.2-3        \n [82] cowplot_1.1.1         grid_4.3.1            tidyr_1.3.0          \n [85] rbibutils_2.2.15      colorspace_2.1-0      cli_3.6.1            \n [88] tern_0.9.0            fansi_1.0.4           expm_0.999-7         \n [91] viridisLite_0.4.2     gtable_0.3.4          rstatix_0.7.2        \n [94] sass_0.4.7            digest_0.6.33         ggrepel_0.9.3        \n [97] htmlwidgets_1.6.2     farver_2.1.1          memoise_2.0.1        \n[100] htmltools_0.5.6       lifecycle_1.0.3       shinyWidgets_0.8.0   \n[103] httr_1.4.7            mime_0.12             MASS_7.3-60          \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkpg04.html",
+    "href": "graphs/pharmacokinetic/pkpg04.html",
+    "title": "PKPG04",
+    "section": "",
+    "text": "Data Setup\nPlot of CMAX by Visit\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(ggrepel)\nlibrary(nestcolor)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\n\n\n\n\nCode# filtered parameter\nadpp &lt;- adpp %&gt;% filter(toupper(PARAMCD) == \"CMAX\" & toupper(PPSPEC) == \"PLASMA\")\n\nuse_title &lt;- paste0(\"Boxplot of \", as.character(unique(adpp$PARAM)), \" by Visit\")\nuse_subtitle &lt;- paste0(\"Analyte:\\nPK Parameter: \", as.character(unique(adpp$PARAM)), \" (\", as.character(unique(adpp$AVALU)), \")\")\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\np &lt;- ggplot(adpp, aes(x = AVISIT, y = AVAL, fill = ACTARM, label = SUBJID)) +\n  geom_boxplot(outlier.size = 2) +\n  stat_boxplot(geom = \"errorbar\") +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(0.75)) +\n  geom_text_repel(\n    data = . %&gt;% dplyr::group_by(AVISIT, ACTARM) %&gt;% dplyr::filter(AVAL %in% boxplot.stats(AVAL)$out),\n    aes(x = AVISIT, y = AVAL, label = SUBJID, color = ACTARM),\n    size = 3, hjust = -0.2, position = position_dodge(0.75)\n  ) +\n  labs(\n    title = use_title,\n    subtitle = use_subtitle,\n    caption = use_footnote,\n    x = \"Visit\",\n    y = paste0(as.character(unique(adpp$PARAM)), \" (\", as.character(unique(adpp$AVALU)), \")\")\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\nplot &lt;- p + geom_point(aes(fill = ACTARM), size = 2, shape = 21, position = position_dodge(0.75))\nplot\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggrepel_0.9.3    ggplot2_3.4.3    dplyr_1.1.3     \n[5] scda_0.1.6       tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[9] formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   \n [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    \n [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       \n[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     \n[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      \n[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      \n[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 \n[29] broom_1.0.5       vctrs_0.6.3       R6_2.5.1          lifecycle_1.0.3  \n[33] htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0      gtable_0.3.4     \n[37] glue_1.6.2        Rcpp_1.0.11       xfun_0.40         tibble_3.2.1     \n[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     \n[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  \n[49] compiler_4.3.1   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkpg03.html",
+    "href": "graphs/pharmacokinetic/pkpg03.html",
+    "title": "PKPG03",
+    "section": "",
+    "text": "Data Setup\nPlot of CMAX by Visit\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\n\n\n\n\nCode# filtered parameter\nadpp &lt;- adpp %&gt;% filter(PARAMCD == \"CMAX\", PPSPEC == \"Plasma\")\n\nuse_title &lt;- paste0(\"Boxplot of \", as.character(unique(adpp$PARAM)), \" by Visit\")\nuse_subtitle &lt;- paste0(\"Analyte:\\nPK Parameter: \", as.character(unique(adpp$PARAM)), \" (\", as.character(unique(adpp$AVALU)), \")\")\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nplot &lt;- ggplot(adpp, aes(x = AVISIT, y = AVAL, fill = ACTARM, label = SUBJID)) +\n  geom_boxplot(outlier.size = 2) +\n  stat_boxplot(geom = \"errorbar\") +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(0.75)) +\n  geom_text(\n    data = . %&gt;% dplyr::group_by(AVISIT, ACTARM) %&gt;% dplyr::filter(AVAL %in% boxplot.stats(AVAL)$out),\n    aes(x = AVISIT, y = AVAL, label = SUBJID, color = ACTARM),\n    size = 3, hjust = -0.2, position = position_dodge(0.75)\n  ) +\n  labs(\n    title = use_title,\n    subtitle = use_subtitle,\n    caption = use_footnote,\n    x = \"Visit\",\n    y = paste0(as.character(unique(adpp$PARAM)), \" (\", as.character(unique(adpp$AVALU)), \")\")\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\nplot\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkcg02.html",
+    "href": "graphs/pharmacokinetic/pkcg02.html",
+    "title": "PKCG02",
+    "section": "",
+    "text": "Data Setup\nPlot in Linear Scale\nPlot in Log Scale\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\")\n\n\n\n\n\nCodeadpc_a &lt;- adpc %&gt;%\n  filter(\n    PARAM == \"Plasma Drug X\",\n    ARMCD == \"ARM A\"\n  ) %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID)) %&gt;%\n  filter(Patient_ID %in% unique(Patient_ID)[1:10])\n\nuse_title1 &lt;- \"Plot of X Concentration (ug/mL) Over Time by Treatment: \\nPK Evaluable Patients\"\nuse_subtitle1 &lt;- \"Analyte: Plasma X (ug/mL) \\nTreatment Group: ARM A\"\nuse_footnote1 &lt;- \"Program: \\nOutput:\"\n\nplot &lt;- g_ipp(\n  df = adpc_a,\n  xvar = \"NFRLT\",\n  yvar = \"AVAL\",\n  xlab = \"Norminal Time from First Dose (hr)\",\n  ylab = \"Concentration (ug/mL)\",\n  id_var = \"Patient_ID\",\n  add_baseline_hline = F,\n  yvar_baseline = \"AVAL\", #  yvar_baseline cannot be NA or ignore\n  title = use_title1,\n  subtitle = use_subtitle1,\n  caption = use_footnote1,\n  plotting_choices = \"all_in_one\"\n)\nplot\n\n\n\n\n\n\n\nCodeadpc_a &lt;- adpc %&gt;%\n  filter(\n    PARAM == \"Plasma Drug X\",\n    ARMCD == \"ARM A\"\n  ) %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID)) %&gt;%\n  mutate(avalog = ifelse(AVAL != 0, AVAL, 0.001)) %&gt;%\n  filter(Patient_ID %in% unique(Patient_ID)[1:10])\n\nuse_title3 &lt;- \"Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: \\nPK Evaluable Patients\"\nuse_subtitle3 &lt;- \"Analyte: Plasma X (ug/mL) \\nTreatment Group: ARM A\"\nuse_footnote3 &lt;- \"Program: \\nOutput:\"\n\nresult &lt;- g_ipp(\n  df = adpc_a,\n  xvar = \"NFRLT\",\n  yvar = \"avalog\",\n  xlab = \"Norminal Time from First Dose (hr)\",\n  ylab = \"Concentration (ug/mL)\",\n  id_var = \"Patient_ID\",\n  add_baseline_hline = F,\n  yvar_baseline = \"AVAL\", #  yvar_baseline cannot be NA or ignore\n  title = use_title3,\n  caption = use_footnote3,\n  subtitle = use_subtitle3,\n  plotting_choices = \"all_in_one\"\n)\nplot &lt;- result + ggplot2::scale_y_log10(breaks = c(0.001, 0.01, 0.1, 1, 10), label = c(0.001, 0.01, 0.1, 1, 10))\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkpg01.html",
+    "href": "graphs/pharmacokinetic/pkpg01.html",
+    "title": "PKPG01",
+    "section": "",
+    "text": "Data Setup\nPlot with Two Cohorts\nPlot with Six Cohorts\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\nset.seed(123)\n\n# loading in the data\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\n# filtering the rows for specific data entries\nadpp &lt;- adpp %&gt;%\n  filter(PARAMCD == \"RCPCINT\", AVISIT == \"CYCLE 1 DAY 1\", PPCAT == \"Plasma Drug X\")\n\n# adding or modifying specific columns\nadpp &lt;- adpp %&gt;%\n  mutate(ARM = as.factor(TRT01A)) %&gt;%\n  mutate(PARAM1 = \"Fe\") %&gt;% # re-format PK parameter name\n  mutate(Time = as.numeric(gsub(\"PT*|\\\\.|H$\", \"\", PPENINT))) %&gt;%\n  droplevels() %&gt;%\n  df_explicit_na()\n\n# in cases where the cohorts are numeric it is possible to rename them\nlevels(adpp$ARM) &lt;- c(\n  \"A: Drug X\",\n  \"C: Combination\"\n)\n\n\n\n\n\nCodeuse_title &lt;- \"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine \\nby Analyte, Visit: PK Evaluable Patients\"\nuse_subtitle &lt;- \"Analyte: Plasma Drug X \\nVisit: CYCLE 1 DAY 1 \\nPK Parameter:\"\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nseparation_between_barplots &lt;- 1.5\n\nresult &lt;- g_lineplot(\n  df = adpp,\n  variables = control_lineplot_vars(\n    x = \"Time\",\n    y = \"AVAL\",\n    strata = \"ARM\",\n    paramcd = \"PARAM1\",\n    y_unit = \"AVALU\"\n  ),\n  alt_counts_df = adpp,\n  y_lab = \"Cummulative Percentage\",\n  x_lab = \"Time (hours)\",\n  y_lab_add_paramcd = FALSE,\n  y_lab_add_unit = TRUE,\n  interval = \"mean_sdi\",\n  whiskers = c(\"mean_sdi_lwr\", \"mean_sdi_upr\"),\n  title = use_title,\n  subtitle = use_subtitle,\n  caption = use_footnote,\n  ggtheme = theme_nest(),\n  position = ggplot2::position_dodge(width = 2)\n)\n\nplot &lt;- result + theme(plot.caption = element_text(hjust = 0)) +\n  scale_x_continuous(breaks = c(12, 24))\nplot\n\n\n\n\n\n\nIn this case we need to process the data further by artificially adding more random rows. Of course this step is not necessary in the case that data already has more cohorts.\n\nCodeadpp_hck &lt;- adpp %&gt;%\n  mutate(AVAL + 1 * rnorm(nrow(adpp), mean = 1, sd = 1)) %&gt;%\n  mutate(ARM = as.factor(sample(\n    c(\n      \"D: Drug D\",\n      \"E: Drug E\",\n      \"F: Drug F\",\n      \"G: Drug G\"\n    ),\n    nrow(adpp),\n    replace = TRUE,\n    prob = c(0.4, 0.3, 0.2, 0.1)\n  )))\n\nadpp &lt;- bind_rows(adpp, adpp_hck)\n\nuse_title &lt;- \"Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine \\nby Analyte, Visit: PK Evaluable Patients\"\nuse_subtitle &lt;- \"Analyte: Plasma Drug X \\nVisit: CYCLE 1 DAY 1 \\nPK Parameter:\"\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nseparation_between_barplots &lt;- 1.5\n\nresult &lt;- g_lineplot(\n  df = adpp,\n  variables = control_lineplot_vars(\n    x = \"Time\",\n    y = \"AVAL\",\n    strata = \"ARM\",\n    paramcd = \"PARAM1\",\n    y_unit = \"AVALU\"\n  ),\n  alt_counts_df = adpp,\n  y_lab = \"Cummulative Percentage\",\n  x_lab = \"Time (hours)\",\n  y_lab_add_paramcd = FALSE,\n  y_lab_add_unit = TRUE,\n  interval = \"mean_sdi\",\n  whiskers = c(\"mean_sdi_lwr\", \"mean_sdi_upr\"),\n  title = use_title,\n  subtitle = use_subtitle,\n  caption = use_footnote,\n  ggtheme = theme_nest(),\n  position = ggplot2::position_dodge(width = 2)\n)\n\nplot &lt;- result + theme(plot.caption = element_text(hjust = 0)) +\n  scale_x_continuous(breaks = c(12, 24))\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   \n [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    \n [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       \n[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     \n[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      \n[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      \n[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 \n[29] forcats_1.0.0     broom_1.0.5       vctrs_0.6.3       R6_2.5.1         \n[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     \n[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     \n[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     \n[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  \n[49] compiler_4.3.1   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/efficacy/fstg02.html",
+    "href": "graphs/efficacy/fstg02.html",
+    "title": "FSTG02",
+    "section": "",
+    "text": "Data Setup\nStandard Plot\nPlot Specifying Class Variables and  Options for the Treatment Variable\nPlot Selecting Columns and  Changing the Alpha Level)\nPlot with Fixed  Symbol Size\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(forcats)\nlibrary(nestcolor)\nlibrary(scda)\n\npreprocess_adtte &lt;- function(adtte) {\n  # Save variable labels before data processing steps.\n  adtte_labels &lt;- var_labels(adtte)\n\n  adtte &lt;- adtte %&gt;%\n    df_explicit_na() %&gt;%\n    dplyr::filter(\n      PARAMCD == \"OS\",\n      ARM %in% c(\"B: Placebo\", \"A: Drug X\"),\n      SEX %in% c(\"M\", \"F\")\n    ) %&gt;%\n    dplyr::mutate(\n      # Reorder levels of ARM to display reference arm before treatment arm.\n      ARM = droplevels(forcats::fct_relevel(ARM, \"B: Placebo\")),\n      SEX = droplevels(SEX),\n      is_event = CNSR == 0,\n      # Convert time to MONTH\n      AVAL = day2month(AVAL),\n      AVALU = \"Months\"\n    ) %&gt;%\n    var_relabel(\n      ARM = adtte_labels[\"ARM\"],\n      SEX = adtte_labels[\"SEX\"],\n      is_event = \"Event Flag\",\n      AVAL = adtte_labels[\"AVAL\"],\n      AVALU = adtte_labels[\"AVALU\"]\n    )\n\n  adtte\n}\n\nanl &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\") %&gt;%\n  preprocess_adtte()\n\n\n\n\n\nCodeanl1 &lt;- anl\n\ndf &lt;- extract_survival_subgroups(\n  variables = list(tte = \"AVAL\", is_event = \"is_event\", arm = \"ARM\", subgroups = c(\"SEX\", \"BMRKR2\")),\n  data = anl1\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_survival_subgroups(\n    df = df,\n    vars = c(\"n_tot\", \"n\", \"median\", \"hr\", \"ci\"),\n    time_unit = anl1$AVALU[1]\n  )\nresult\n\nBaseline Risk Factors                          B: Placebo               A: Drug X                                    \n                                Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                      268     134         NA          134         NA              1.00       (0.69, 1.44)\nSex                                                                                                                  \n  F                               161     82          NA          79          NA              0.79       (0.49, 1.28)\n  M                               107     52          NA          55          9.6             1.39       (0.78, 2.47)\nCategorical Level Biomarker 2                                                                                        \n  LOW                             95      45          NA          50          9.3             1.14       (0.64, 2.02)\n  MEDIUM                          93      56          NA          37          NA              0.97       (0.52, 1.82)\n  HIGH                            80      33          NA          47          NA              0.97       (0.45, 2.12)\n\nCode# Add plot.\np &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodeanl2 &lt;- anl %&gt;%\n  mutate(\n    # Recode levels of arm.\n    ARM = forcats::fct_recode(\n      ARM,\n      \"Placebo\" = \"B: Placebo\",\n      \"Drug X\" = \"A: Drug X\"\n    ),\n    # Reorder levels of `SEX`.\n    SEX = forcats::fct_relevel(SEX, \"M\", \"F\"),\n    # Reorder levels of `STRATA1`` by frequency.\n    STRATA1 = forcats::fct_infreq(STRATA1)\n  )\n\ndf &lt;- extract_survival_subgroups(\n  variables = list(tte = \"AVAL\", is_event = \"is_event\", arm = \"ARM\", subgroups = c(\"SEX\", \"STRATA1\")),\n  data = anl2\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_survival_subgroups(\n    df = df,\n    vars = c(\"n_tot\", \"n\", \"median\", \"hr\", \"ci\"),\n    time_unit = anl2$AVALU[1]\n  )\nresult\n\nBaseline Risk Factors                      Placebo                 Drug X                                      \n                          Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                268     134         NA          134         NA              1.00       (0.69, 1.44)\nSex                                                                                                            \n  M                         107     52          NA          55          9.6             1.39       (0.78, 2.47)\n  F                         161     82          NA          79          NA              0.79       (0.49, 1.28)\nStratification Factor 1                                                                                        \n  C                         94      45          NA          49          NA              0.75       (0.41, 1.38)\n  B                         92      45          NA          47          NA              1.34       (0.71, 2.54)\n  A                         82      44          NA          38          NA              1.02       (0.53, 1.97)\n\nCodep &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodeanl3 &lt;- anl\n\ndf &lt;- extract_survival_subgroups(\n  variables = list(tte = \"AVAL\", is_event = \"is_event\", arm = \"ARM\", subgroups = c(\"SEX\", \"BMRKR2\")),\n  control = control_coxph(conf_level = 0.9),\n  data = anl3\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_survival_subgroups(\n    df = df,\n    vars = c(\"n_tot\", \"hr\", \"ci\")\n  )\nresult\n\nBaseline Risk Factors                                                \n                                Total n   Hazard Ratio   90% Wald CI \n—————————————————————————————————————————————————————————————————————\nAll Patients                      268         1.00       (0.74, 1.36)\nSex                                                                  \n  F                               161         0.79       (0.53, 1.19)\n  M                               107         1.39       (0.86, 2.25)\nCategorical Level Biomarker 2                                        \n  LOW                             95          1.14       (0.71, 1.84)\n  MEDIUM                          93          0.97       (0.58, 1.64)\n  HIGH                            80          0.97       (0.51, 1.87)\n\nCode# Add plot.\np &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodeanl4 &lt;- anl\n\ndf &lt;- extract_survival_subgroups(\n  variables = list(tte = \"AVAL\", is_event = \"is_event\", arm = \"ARM\", subgroups = c(\"SEX\", \"BMRKR2\")),\n  data = anl4\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_survival_subgroups(\n    df = df,\n    vars = c(\"n_tot\", \"n\", \"median\", \"hr\", \"ci\"),\n    time_unit = anl4$AVALU[1]\n  )\nresult\n\nBaseline Risk Factors                          B: Placebo               A: Drug X                                    \n                                Total n    n    Median (Months)    n    Median (Months)   Hazard Ratio   95% Wald CI \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                      268     134         NA          134         NA              1.00       (0.69, 1.44)\nSex                                                                                                                  \n  F                               161     82          NA          79          NA              0.79       (0.49, 1.28)\n  M                               107     52          NA          55          9.6             1.39       (0.78, 2.47)\nCategorical Level Biomarker 2                                                                                        \n  LOW                             95      45          NA          50          9.3             1.14       (0.64, 2.02)\n  MEDIUM                          93      56          NA          37          NA              0.97       (0.52, 1.82)\n  HIGH                            80      33          NA          47          NA              0.97       (0.45, 2.12)\n\nCode# Add plot.\np &lt;- g_forest(\n  tbl = result,\n  col_symbol_size = NULL\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADSL &lt;- ADSL %&gt;%\n  dplyr::filter(ARM %in% c(\"B: Placebo\", \"A: Drug X\")) %&gt;%\n  dplyr::mutate(ARM = droplevels(forcats::fct_relevel(ARM, \"B: Placebo\"))) %&gt;%\n  dplyr::mutate(ARMCD = droplevels(forcats::fct_relevel(ARMCD, \"ARM B\")))\nADSL$RACE &lt;- droplevels(ADSL$RACE)\n\nADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\nadtte_labels &lt;- var_labels(ADTTE)\n\nADTTE &lt;- ADTTE %&gt;%\n  dplyr::filter(\n    PARAMCD == \"OS\",\n    ARM %in% c(\"B: Placebo\", \"A: Drug X\"),\n    SEX %in% c(\"M\", \"F\")\n  ) %&gt;%\n  dplyr::mutate(\n    # Reorder levels of ARM to display reference arm before treatment arm.\n    ARM = droplevels(forcats::fct_relevel(ARM, \"B: Placebo\")),\n    SEX = droplevels(SEX),\n    is_event = CNSR == 0,\n    # Convert time to MONTH\n    AVAL = day2month(AVAL),\n    AVALU = \"Months\"\n  ) %&gt;%\n  var_relabel(\n    ARM = adtte_labels[\"ARM\"],\n    SEX = adtte_labels[\"SEX\"],\n    is_event = \"Event Flag\",\n    AVAL = adtte_labels[\"AVAL\"],\n    AVALU = adtte_labels[\"AVALU\"]\n  )\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n      ADSL &lt;- ADSL %&gt;%\n        dplyr::filter(ARM %in% c(\"B: Placebo\", \"A: Drug X\")) %&gt;%\n        dplyr::mutate(ARM = droplevels(forcats::fct_relevel(ARM, \"B: Placebo\"))) %&gt;%\n        dplyr::mutate(ARMCD = droplevels(forcats::fct_relevel(ARMCD, \"ARM B\")))\n      ADSL$RACE &lt;- droplevels(ADSL$RACE)\n      '\n    ),\n    cdisc_dataset(\"ADTTE\", ADTTE, code = '\n                  ADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n                  adtte_labels &lt;- var_labels(ADTTE)\n                  ADTTE &lt;- ADTTE %&gt;%\n                    dplyr::filter(\n                      PARAMCD == \"OS\",\n                      ARM %in% c(\"B: Placebo\", \"A: Drug X\"),\n                      SEX %in% c(\"M\", \"F\")\n                    ) %&gt;%\n                    dplyr::mutate(\n                      # Reorder levels of ARM to display reference arm before treatment arm.\n                      ARM = droplevels(forcats::fct_relevel(ARM, \"B: Placebo\")),\n                      SEX = droplevels(SEX),\n                      is_event = CNSR == 0,\n                      # Convert time to MONTH\n                      AVAL = day2month(AVAL),\n                      AVALU = \"Months\"\n                    ) %&gt;%\n                    var_relabel(\n                      ARM = adtte_labels[\"ARM\"],\n                      SEX = adtte_labels[\"SEX\"],\n                      is_event = \"Event Flag\",\n                      AVAL = adtte_labels[\"AVAL\"],\n                      AVALU = adtte_labels[\"AVALU\"]\n                    )\n                  '),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_g_forest_tte(\n      label = \"Forest Survival\",\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      subgroup_var = choices_selected(names(ADSL), c(\"SEX\", \"BMRKR2\")),\n      paramcd = choices_selected(value_choices(ADTTE, \"PARAMCD\", \"PARAM\"), \"OS\"),\n      strata_var = choices_selected(c(\"STRATA1\", \"STRATA2\"), \"STRATA2\"),\n      plot_height = c(600, 200, 2000),\n      plot_width = c(1500, 200, 5000)\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:48:28.8738 pid:5106 token:[] teal.modules.clinical Initializing tm_g_forest_tte\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   nestcolor_0.1.2             \n [9] forcats_1.0.0                dplyr_1.1.3                 \n[11] tern_0.9.0                   rtables_0.6.3               \n[13] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       R6_2.5.1              Rdpack_2.5           \n[67] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[70] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[73] teal.reporter_0.2.1   httpuv_1.6.11         bslib_0.5.1          \n[76] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[79] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[82] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/efficacy/fstg01.html",
+    "href": "graphs/efficacy/fstg01.html",
+    "title": "FSTG01",
+    "section": "",
+    "text": "Data Setup\nStandard Plot\nPlot Specifying Class Variables and  Options for the Treatment Variable\nPlot Selecting Columns and  Changing the Alpha Level\nPlot with Fixed  Symbol Size\nPlot of CR Only, Setting  Values Indicating Response\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\nlibrary(nestcolor)\n\nadsl_f &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n  select(STUDYID, USUBJID, ARMCD, ARM, SEX, BMRKR2, STRATA1, STRATA2)\n\nadrs_f &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\") %&gt;%\n  filter(PARAMCD == \"INVET\") %&gt;%\n  select(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)\n\nanl &lt;- inner_join(adsl_f, adrs_f, by = c(\"STUDYID\", \"USUBJID\"))\nanl &lt;- df_explicit_na(anl)\nanl_labels &lt;- var_labels(anl)\n\nanl_rsp_arms_ab &lt;- anl %&gt;%\n  mutate(is_rsp = AVALC %in% c(\"CR\", \"PR\")) %&gt;%\n  filter(ARMCD %in% c(\"ARM B\", \"ARM A\")) %&gt;%\n  mutate(\n    ARMCD = relevel(ARMCD, ref = \"ARM B\") %&gt;%\n      droplevels(),\n    ARM = relevel(ARM, ref = \"B: Placebo\") %&gt;%\n      droplevels()\n  ) %&gt;%\n  droplevels()\nvar_labels(anl_rsp_arms_ab) &lt;- c(anl_labels, is_rsp = \"Is Responder\")\n\n\n\n\n\nCodedf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"is_rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"BMRKR2\"),\n    strata_var = \"STRATA2\"\n  ),\n  data = anl_rsp_arms_ab,\n  conf_level = 0.95\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\np &lt;- g_forest(\n  tbl = result\n)\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodeanl_rsp_comb_arms_ac &lt;- anl %&gt;%\n  mutate(is_rsp = AVALC %in% c(\"CR\", \"PR\")) %&gt;%\n  filter(ARMCD %in% c(\"ARM B\", \"ARM A\", \"ARM C\")) %&gt;%\n  mutate(\n    ARMCD = relevel(ARMCD, ref = \"ARM B\") %&gt;%\n      droplevels() %&gt;%\n      combine_levels(levels = c(\"ARM A\", \"ARM C\")),\n    ARM = relevel(ARM, ref = \"B: Placebo\") %&gt;%\n      droplevels() %&gt;%\n      combine_levels(levels = c(\"A: Drug X\", \"C: Combination\")),\n    # reorder levels of SEX\n    SEX = forcats::fct_relevel(SEX, \"M\", \"F\"),\n    # reorder levels of STRATA1 by frequency\n    STRATA1 = forcats::fct_infreq(STRATA1)\n  ) %&gt;%\n  droplevels()\nvar_labels(anl_rsp_comb_arms_ac) &lt;- c(anl_labels, is_rsp = \"Is Responder\")\n\ndf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"is_rsp\",\n    arm = \"ARMCD\",\n    subgroups = c(\"SEX\", \"BMRKR2\"),\n    strata_var = \"STRATA2\"\n  ),\n  data = anl_rsp_comb_arms_ac,\n  conf_level = 0.95\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\np &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodedf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"is_rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"BMRKR2\"),\n    strata_var = \"STRATA2\"\n  ),\n  data = anl_rsp_arms_ab,\n  conf_level = 0.90\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"or\", \"ci\"))\n\np &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodedf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"is_rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"BMRKR2\"),\n    strata_var = \"STRATA2\"\n  ),\n  data = anl_rsp_arms_ab,\n  conf_level = 0.95\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\np &lt;- g_forest(\n  tbl = result,\n  col_symbol_size = NULL\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodeanl_cr_arms_ab &lt;- anl %&gt;%\n  mutate(is_rsp = AVALC == \"CR\") %&gt;%\n  filter(ARMCD %in% c(\"ARM B\", \"ARM A\")) %&gt;%\n  mutate(\n    ARMCD = relevel(ARMCD, ref = \"ARM B\") %&gt;%\n      droplevels(),\n    ARM = relevel(ARM, ref = \"B: Placebo\") %&gt;%\n      droplevels()\n  ) %&gt;%\n  droplevels()\nvar_labels(anl_cr_arms_ab) &lt;- c(anl_labels, is_rsp = \"Is CR\")\n\ndf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"is_rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"BMRKR2\"),\n    strata_var = \"STRATA2\"\n  ),\n  data = anl_cr_arms_ab,\n  conf_level = 0.95\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\np &lt;- g_forest(\n  tbl = result\n)\n\ngrid::grid.draw(p)\n\n\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\narm_ref_comp &lt;- list(\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  ),\n  ARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADRS\", ADRS, code = 'ADRS &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_g_forest_rsp(\n      label = \"Forest Response\",\n      dataname = \"ADRS\",\n      arm_var = choices_selected(\n        variable_choices(ADSL, c(\"ARM\", \"ARMCD\")),\n        \"ARMCD\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(ADRS, \"PARAMCD\", \"PARAM\"),\n        \"BESRSPI\"\n      ),\n      subgroup_var = choices_selected(\n        variable_choices(ADSL, names(ADSL)),\n        c(\"BMRKR2\", \"SEX\")\n      ),\n      strata_var = choices_selected(\n        variable_choices(ADSL, c(\"STRATA1\", \"STRATA2\")),\n        \"STRATA2\"\n      ),\n      plot_height = c(600L, 200L, 2000L),\n      plot_width = c(1100L, 200L, 2000L)\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:46:52.0233 pid:4888 token:[] teal.modules.clinical Initializing tm_g_forest_rsp\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n[13] scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       R6_2.5.1              Rdpack_2.5           \n[67] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[70] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[73] teal.reporter_0.2.1   httpuv_1.6.11         bslib_0.5.1          \n[76] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[79] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[82] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "appendix/reproducibility.html#session-info",
+    "href": "appendix/reproducibility.html#session-info",
+    "title": "Reproducibility",
+    "section": "Session Info",
+    "text": "Session Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nloaded via a namespace (and not attached):\n [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    \n [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  \n [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   \n[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    \n[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2\n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodewithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(\"..\", lockfile = \"../assets/www/renv.lock\", prompt = FALSE, force = TRUE)\n)\n\n\nNOTE: Dependency discovery took 18 seconds during snapshot.\nConsider using .renvignore to ignore files, or switching to explicit snapshots.\nSee `?renv::dependencies` for more information.\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/development-safety-update-report/dsur4.html",
+    "href": "listings/development-safety-update-report/dsur4.html",
+    "title": "DSUR4",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\nout &lt;- adsl %&gt;%\n  filter(DTHFL == \"Y\") %&gt;%\n  mutate(ID = paste(SITEID, SUBJID, sep = \"/\")) %&gt;%\n  select(ARM, ID, DTHCAUS)\ndeath_num &lt;- length(unique(out$ID))\nvar_labels(out) &lt;- c(\n  ARM = \"Treatment Group\",\n  ID = \"Center/Patient ID\",\n  DTHCAUS = \"Cause of Death\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ARM\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Patients Who Died During Reporting Period\",\n  subtitles = paste(\"Number of patient deaths during reporting period =\", death_num)\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Patients Who Died During Reporting Period\nNumber of patient deaths during reporting period = 70\n\n———————————————————————————————————————————————————————————————————\nTreatment Group   Center/Patient ID          Cause of Death        \n———————————————————————————————————————————————————————————————————\n   A: Drug X        CHN-3/id-128              ADVERSE EVENT        \n                     RUS-1/id-52           DISEASE PROGRESSION     \n                    CHN-1/id-235              ADVERSE EVENT        \n                    CHN-5/id-108                 MISSING           \n                    CHN-17/id-182           LOST TO FOLLOW UP      \n                    BRA-11/id-217             ADVERSE EVENT        \n                    CHN-15/id-14           DISEASE PROGRESSION     \n                    CHN-2/id-274                 SUICIDE           \n                    USA-11/id-339                UNKNOWN           \n                    BRA-15/id-36           DISEASE PROGRESSION     \n                    CHN-1/id-199           DISEASE PROGRESSION     \n                    CHN-2/id-272           DISEASE PROGRESSION     \n                    CHN-1/id-123           DISEASE PROGRESSION     \n                    CHN-12/id-258                SUICIDE           \n                    CHN-17/id-92            LOST TO FOLLOW UP      \n                     NGA-1/id-46           DISEASE PROGRESSION     \n                     BRA-1/id-93              ADVERSE EVENT        \n                     CHN-6/id-30      Post-study reporting of death\n                    CAN-11/id-139             ADVERSE EVENT        \n                    GBR-1/id-319              ADVERSE EVENT        \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/disposition/dsl02.html",
+    "href": "listings/disposition/dsl02.html",
+    "title": "DSL02",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\nout &lt;- adsl %&gt;%\n  filter(AEWITHFL == \"Y\") %&gt;%\n  mutate(\n    ID = paste(SITEID, SUBJID, sep = \"/\"),\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    DISCONT = ifelse(!is.na(DCSREAS) & EOSSTT != \"COMPLETED\", \"Yes\", \"No\"),\n    SSADTM = as.POSIXct(\n      strftime(TRTSDTM, format = \"%Y-%m-%d %H:%M:%S\"),\n      format = \"%Y-%m-%d\",\n      tz = \"UTC\"\n    ),\n    SSAEDY = as.numeric(ceiling(difftime(EOSDT, SSADTM, units = \"days\"))),\n    RANDEDY = as.numeric(ceiling(difftime(EOSDT, RANDDT, units = \"days\"))),\n  ) %&gt;%\n  filter(DISCONT == \"Yes\") %&gt;%\n  select(ID, ASR, TRT01A, SSADTM, EOSDY, SSAEDY, RANDEDY, DCSREAS)\n\nvar_labels(out) &lt;- c(\n  ID = \"Center/Patient ID\",\n  ASR = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  SSADTM = \"Date of First\\nStudy Drug\\nAdministration\",\n  EOSDY = \"Day of Last\\nStudy Drug\\nAdministration\",\n  SSAEDY = \"Day of Study\\nDiscontinuation\\nRelative to First\\nStudy Drug\\nAdministration\",\n  RANDEDY = \"Day of Study\\nDiscontinuation\\nRelative to\\nRandomization\",\n  DCSREAS = \"Reason for\\nDiscontinuation\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  disp_cols = names(out),\n  main_title = \"Listing of Patients Who Discontinued Early from Study\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Patients Who Discontinued Early from Study\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                                          Day of Study                                        \n                                                                                                                         Discontinuation     Day of Study                     \n                                                                                      Date of First     Day of Last     Relative to First   Discontinuation                   \n                                                                                        Study Drug       Study Drug        Study Drug         Relative to        Reason for   \nCenter/Patient ID                    Age/Sex/Race                      Treatment      Administration   Administration    Administration      Randomization    Discontinuation \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   CHN-1/id-62                        36/F/WHITE                       A: Drug X        2020-11-22          455                454                455              DEATH      \n  CHN-11/id-91              44/M/BLACK OR AFRICAN AMERICAN           C: Combination     2020-05-29          625                625                626              DEATH      \n   CHN-9/id-11      28/F/NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER     B: Placebo       2021-01-27          388                387                388              DEATH      \n  USA-11/id-100                       40/F/ASIAN                     C: Combination     2020-03-10          705                705                707         LACK OF EFFICACY\n  USA-11/id-136                       38/F/ASIAN                     C: Combination     2019-10-02          865                864                868              DEATH      \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/lab-results/lbl02a_rls.html",
+    "href": "listings/lab-results/lbl02a_rls.html",
+    "title": "LBL02A_RLS",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_x &lt;- adlb %&gt;%\n  filter(\n    LBTEST != \"\"\n  ) %&gt;%\n  mutate(\n    LBTEST_U = paste0(LBTEST, \" (\", AVALU, \")\"),\n    CPID = paste(SITEID, SUBJID, sep = \"/\")\n  ) %&gt;%\n  mutate(CRC = paste(\"40%\", \"40%\", sep = \" / \"))\n\nstd_rng &lt;- adlb_x %&gt;%\n  group_by(LBTEST_U) %&gt;%\n  summarise(\n    STD_RNG_LO = stats::quantile(AVAL, probs = c(0.1), na.rm = TRUE),\n    STD_RNG_HI = stats::quantile(AVAL, probs = c(0.9), na.rm = TRUE)\n  ) %&gt;%\n  ungroup()\n\nadlb_x &lt;- adlb_x %&gt;%\n  left_join(std_rng, by = \"LBTEST_U\") %&gt;%\n  mutate(\n    AVAL = format(round(AVAL, 1), nsmall = 1),\n    PCHG = format(round(PCHG, 1), nsmall = 1),\n    LBNRNG = paste(ANRLO, ANRHI, sep = \" - \"),\n    STD_RNG_LO = format(round(STD_RNG_LO, 1), nsmall = 1),\n    STD_RNG_HI = format(round(STD_RNG_HI, 1), nsmall = 1)\n  ) %&gt;%\n  mutate(\n    STD_RNG = paste(STD_RNG_LO, STD_RNG_HI, sep = \" - \"),\n    ANRIND = factor(case_when(\n      ANRIND == \"LOW\" & AVAL &gt; STD_RNG_LO ~ \"L\",\n      ANRIND == \"HIGH\" & AVAL &lt; STD_RNG_HI ~ \"H\",\n      ANRIND == \"LOW\" & AVAL &lt;= STD_RNG_LO ~ \"LL\",\n      ANRIND == \"HIGH\" & AVAL &gt;= STD_RNG_HI ~ \"HH\",\n      TRUE ~ \"\"\n    ))\n  ) %&gt;%\n  select(LBTEST_U, TRT01A, CPID, ADY, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND) %&gt;%\n  unique() %&gt;%\n  arrange(CPID, ADY) %&gt;%\n  group_by(LBTEST_U, CPID) %&gt;%\n  mutate(DLD = ADY - lag(ADY)) %&gt;%\n  ungroup() %&gt;%\n  mutate(DLD = ifelse(is.na(DLD), 0, DLD))\n\nout &lt;- adlb_x %&gt;%\n  select(LBTEST_U, TRT01A, CPID, ADY, DLD, AVAL, PCHG, STD_RNG, LBNRNG, CRC, ANRIND)\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    LBTEST_U = \"Lab Test (Unit)\",\n    TRT01A = \"Treatment\",\n    CPID = \"Center/Patient ID\",\n    ADY = \"Study\\nDay\",\n    DLD = \"Days Since\\nLast Dose of\\nStudy Drug\",\n    AVAL = \"Result\",\n    PCHG = \"% Change\\nfrom\\nBaseline\",\n    STD_RNG = \"Standard\\nReference\\nRange\",\n    LBNRNG = \"Marked\\nReference\\nRange\",\n    CRC = \"Clinically\\nRelevant\\nChange\\nDec./Inc.\",\n    ANRIND = \"Abnormality\\nFlag\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"LBTEST_U\", \"TRT01A\", \"CPID\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization\",\n  main_footer = \"Standard reference range, marked reference range and clinically relevant change from baseline are from the Roche Safety Lab\nStandardization guideline.  Abnormalities are flagged as high (H) or low (L) if outside the standard reference range; high high (HH)\nor low low (LL) if outside the marked reference range with a clinically relevant change from baseline.\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                                                                  Clinically              \n                                                                                      Days Since             % Change     Standard     Marked      Relevant               \n                                                                             Study   Last Dose of              from      Reference    Reference     Change     Abnormality\n             Lab Test (Unit)                 Treatment   Center/Patient ID    Day     Study Drug    Result   Baseline      Range        Range     Dec./Inc.       Flag    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (U/L)   A: Drug X     BRA-1/id-105       80          0          4.3        NA       5.5 - 31.1    7 - 55     40% / 40%        LL     \n                                                                              149         69         24.7       0.0      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              314        165         24.9       0.7      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              398         84         3.7       -85.2     5.5 - 31.1    7 - 55     40% / 40%        LL     \n                                                                              470         72         18.5      -24.9     5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              528         58         7.7       -68.7     5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              535         7          23.5      -4.8      5.5 - 31.1    7 - 55     40% / 40%               \n                                                           BRA-1/id-134       225         0          7.4        NA       5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              227         2          16.4       0.0      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              255         28         11.2      -32.0     5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              269         14         15.9      -3.2      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              357         88         24.4      48.3      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              436         79         16.0      -2.4      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              440         4          17.2       4.8      5.5 - 31.1    7 - 55     40% / 40%               \n                                                            BRA-1/id-42       176         0          16.6       NA       5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              477        301         16.5       0.0      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              534         57         18.7      13.4      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              550         16         11.4      -30.6     5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              569         19         21.7      31.3      5.5 - 31.1    7 - 55     40% / 40%               \n                                                                              608         39         24.6      49.2      5.5 - 31.1    7 - 55     40% / 40%               \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nStandard reference range, marked reference range and clinically relevant change from baseline are from the Roche Safety Lab\nStandardization guideline.  Abnormalities are flagged as high (H) or low (L) if outside the standard reference range; high high (HH)\nor low low (LL) if outside the marked reference range with a clinically relevant change from baseline.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/lab-results/lbl02b.html",
+    "href": "listings/lab-results/lbl02b.html",
+    "title": "LBL02B",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_x &lt;- adlb %&gt;%\n  filter(\n    !sub(\"-\", \"\", ATOXGR) %in% c(\"\", \"0\", \"1\"),\n    LBTEST != \"\",\n    !is.na(ADY),\n    !ANRIND %in% c(\"\", \"NORMAL\")\n  ) %&gt;%\n  mutate(\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    ADTM = toupper(format(as.Date(ADTM), \"%d%b%Y\")),\n    AVAL = format(round(AVAL, 1), nsmall = 1),\n    LBNRNG = paste(format(round(ANRLO, 1), nsmall = 1), format(round(ANRHI, 1), nsmall = 1), sep = \" - \"),\n    ANRIND_GR = factor(\n      case_when(\n        ANRIND == \"LOW\" ~ paste0(\"L\", sub(\"-\", \"\", ATOXGR)),\n        ANRIND == \"HIGH\" ~ paste0(\"H\", ATOXGR)\n      )\n    )\n  ) %&gt;%\n  select(LBTEST, TRT01A, CPID, ADY, ADTM, AVAL, AVALU, LBNRNG, ANRIND_GR) %&gt;%\n  unique() %&gt;%\n  arrange(CPID, ADY) %&gt;%\n  group_by(LBTEST, CPID) %&gt;%\n  mutate(DLD = ADY - lag(ADY)) %&gt;%\n  ungroup() %&gt;%\n  mutate(DLD = ifelse(is.na(DLD), 0, DLD))\n\nout &lt;- adlb_x %&gt;%\n  select(LBTEST, TRT01A, CPID, ADY, ADTM, DLD, AVAL, AVALU, LBNRNG, ANRIND_GR)\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    LBTEST = \"Lab Test\",\n    TRT01A = \"Treatment\",\n    CPID = \"Center/Patient ID\",\n    ADY = \"Study\\nDay\",\n    ADTM = \"Date\",\n    DLD = \"Days Since\\nLast Dose of\\nStudy Drug\",\n    AVAL = \"Result\",\n    AVALU = \"Unit\",\n    LBNRNG = \"Lab Normal\\nRange\",\n    ANRIND_GR = \"NCI\\nCTCAE\\nGrade\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"LBTEST\", \"TRT01A\", \"CPID\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 2\",\n  main_footer = \"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 2\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                            Days Since                                  NCI \n                                                                       Study               Last Dose of                   Lab Normal   CTCAE\n              Lab Test                 Treatment   Center/Patient ID    Day      Date       Study Drug    Result   Unit     Range      Grade\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement   A: Drug X     BRA-1/id-105       80     27MAY2020        0          4.3     U/L    7.0 - 55.0    L4  \n                                                                        398    10APR2021       318         3.7     U/L    7.0 - 55.0    L3  \n                                                      CAN-1/id-18       465    12APR2022        0          1.8     U/L    7.0 - 55.0    L2  \n                                                     CHN-1/id-133       127    13DEC2020        0          5.6     U/L    7.0 - 55.0    L2  \n                                                                        197    21FEB2021        70         1.2     U/L    7.0 - 55.0    L4  \n                                                     CHN-1/id-199       277    11OCT2020        0          5.3     U/L    7.0 - 55.0    L4  \n                                                                        672    10NOV2021       395         6.8     U/L    7.0 - 55.0    L2  \n                                                     CHN-1/id-235       348    25JUN2020        0          3.0     U/L    7.0 - 55.0    L3  \n                                                     CHN-1/id-275       364    01JUN2021        0          5.1     U/L    7.0 - 55.0    L2  \n                                                     CHN-1/id-277       483    12MAY2022        0          1.1     U/L    7.0 - 55.0    L4  \n                                                     CHN-1/id-287       182    23MAY2020        0          5.9     U/L    7.0 - 55.0    L2  \n                                                                        191    01JUN2020        9          5.3     U/L    7.0 - 55.0    L3  \n                                                                        515    21APR2021       324         2.9     U/L    7.0 - 55.0    L4  \n                                                     CHN-1/id-315       289    05JUN2020        0          4.6     U/L    7.0 - 55.0    L4  \n                                                                        599    11APR2021       310         5.2     U/L    7.0 - 55.0    L4  \n                                                     CHN-1/id-316       971    14MAY2023        0          3.6     U/L    7.0 - 55.0    L4  \n                                                     CHN-1/id-360       689    01APR2022        0          4.7     U/L    7.0 - 55.0    L2  \n                                                     CHN-1/id-371       81     01MAY2021        0          5.9     U/L    7.0 - 55.0    L2  \n                                                      CHN-1/id-47       236    11SEP2020        0          4.4     U/L    7.0 - 55.0    L3  \n                                                      CHN-1/id-53       98     13FEB2020        0          6.4     U/L    7.0 - 55.0    L2  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nNCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/ADA/adal02.html",
+    "href": "listings/ADA/adal02.html",
+    "title": "ADAL02",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(rlistings)\nlibrary(scda)\n\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\") %&gt;%\n  filter(NFRLT %% 1 == 0 & NFRLT &gt; 0)\n\ntrt &lt;- \"A: Drug X\"\ndrug_a &lt;- \"A: Drug X Antibody\"\ndrugcd &lt;- unique(adab$PARAMCD[adab$PARAM == \"Antibody titer units\"])[1]\nmin_titer &lt;- 1.10\n\nadab_x &lt;- adab %&gt;%\n  filter(\n    ARM == trt,\n    PARCAT1 == drug_a,\n    ADPBLPFL == \"Y\"\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU, -ARRLT, -NRRLT) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  filter(if_any(matches(\"Treatment Emergent - Positive\"), ~ .x == 1)) %&gt;%\n  # filter(`Treatment Emergent - Positive` == 1) %&gt;%\n  mutate(\n    VISN = factor(paste0(\n      VISIT, \"\\n(Day \",\n      ifelse(\n        NFRLT %% 1 == 0,\n        NFRLT,\n        as.character(format(round(NFRLT, 2), nsmall = 2))\n      ),\n      \")\"\n    )),\n    PTES = ifelse(\n      ifelse(\"Treatment induced ADA\" %in% names(.), `Treatment induced ADA` == 1, F),\n      ifelse(\n        \"Transient ADA\" %in% names(.) & `Transient ADA` == 1,\n        \"Induced (Transient)\",\n        \"Induced (Persistent)\"\n      ),\n      \"Enhanced\"\n    )\n  ) %&gt;%\n  mutate(\n    AVAL = paste0(\n      ifelse(\n        ifelse(\"ADA interpreted per sample result\" %in% names(.), `ADA interpreted per sample result` == 0, F),\n        \"NEGATIVE\",\n        ifelse(\n          ifelse(\"Antibody titer units\" %in% names(.), !is.na(`Antibody titer units`), F),\n          ifelse(\n            `Antibody titer units` &lt; min_titer,\n            paste0(\"&lt;\", format(min_titer, nsmall = 2)),\n            as.character(format(round(`Antibody titer units`, 2), nsmall = 2))\n          ),\n          \"---\"\n        )\n      ),\n      ifelse(\n        ifelse(\"NAB interpreted per sample result\" %in% names(.), `NAB interpreted per sample result` == 1, F),\n        \"*\",\n        \"\"\n      )\n    )\n  )\n\nout &lt;- adab_x %&gt;%\n  select(USUBJID, VISN, AVAL, PTES) %&gt;%\n  tidyr::pivot_wider(\n    names_from = VISN,\n    values_from = AVAL\n  ) %&gt;%\n  select(USUBJID, unique(adab_x$VISN[order(adab_x$NFRLT)]), PTES)\n\nvar_labels(out) &lt;- names(out)\n\nout &lt;- out %&gt;%\n  var_relabel(\n    USUBJID = \"Subject ID\",\n    PTES = \"Patient Treatment\\nEmergent ADA Status\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = \"USUBJID\",\n  disp_cols = names(out),\n  main_title = paste0(\n    \"Listing of Anti-\", drugcd, \" Antibody Data for Treatment Emergent ADA Positive Patients, PK Population\",\n    \"\\nProtocol: \", unique(adab$PARCAT1)[1]\n  ),\n  subtitles = paste(\"\\nTreatment Group:\", trt),\n  main_footer = \"Minimum reportable titer = 1.10 (example only)\n--- = No sample evaluated\nADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies)\nNumber of patients positive for Treatment Emergent ADA = the number of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.\nTreatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.\nTreatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\nTransient ADA = ADA positive result detected (a) at only one post-baseline sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints during treatment where the first and last ADA positive samples  are separated by a period of &lt; 16 weeks, irrespective of any negative samples in between.\nPersistent ADA =  ADA positive result detected (a) at the last post-baseline sampling timepoint, OR (b) at 2 or more time points during treatment where the first and last ADA positive samples are separated by a period ≥ 16 weeks, irrespective of any negative samples in between.\nAsterisk denotes sample that tested positive for Neutralizing Antibodies.\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Anti-R1800000 Antibody Data for Treatment Emergent ADA Positive Patients, PK Population\nProtocol: A: Drug X Antibody\n\nTreatment Group: A: Drug X\n\n—————————————————————————————————————————————————————\n                         Day 2     Patient Treatment \n     Subject ID         (Day 1)   Emergent ADA Status\n—————————————————————————————————————————————————————\nAB12345-BRA-1-id-105      ---          Enhanced      \nAB12345-BRA-1-id-134      ---          Enhanced      \n AB12345-BRA-1-id-42      ---          Enhanced      \n AB12345-BRA-1-id-93      ---          Enhanced      \nAB12345-BRA-11-id-217     ---          Enhanced      \nAB12345-BRA-11-id-345     ---          Enhanced      \nAB12345-BRA-11-id-397     ---          Enhanced      \nAB12345-BRA-11-id-50      ---          Enhanced      \nAB12345-BRA-13-id-177     ---          Enhanced      \nAB12345-BRA-14-id-23      ---          Enhanced      \nAB12345-BRA-15-id-36      ---          Enhanced      \nAB12345-BRA-2-id-296      ---          Enhanced      \nAB12345-BRA-6-id-369      ---          Enhanced      \n AB12345-CAN-1-id-18      ---          Enhanced      \nAB12345-CAN-11-id-139     ---          Enhanced      \nAB12345-CAN-14-id-104     ---          Enhanced      \nAB12345-CHN-1-id-119      ---          Enhanced      \nAB12345-CHN-1-id-123      ---          Enhanced      \nAB12345-CHN-1-id-133      ---          Enhanced      \nAB12345-CHN-1-id-199      ---          Enhanced      \n—————————————————————————————————————————————————————\n\nMinimum reportable titer = 1.10 (example only)\n--- = No sample evaluated\nADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies)\nNumber of patients positive for Treatment Emergent ADA = the number of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.\nTreatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.\nTreatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\nTransient ADA = ADA positive result detected (a) at only one post-baseline sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints during treatment where the first and last ADA positive samples  are separated by a period of &lt; 16 weeks, irrespective of any negative samples in between.\nPersistent ADA =  ADA positive result detected (a) at the last post-baseline sampling timepoint, OR (b) at 2 or more time points during treatment where the first and last ADA positive samples are separated by a period ≥ 16 weeks, irrespective of any negative samples in between.\nAsterisk denotes sample that tested positive for Neutralizing Antibodies.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael04.html",
+    "href": "listings/adverse-events/ael04.html",
+    "title": "AEL04",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\nout &lt;- adsl %&gt;%\n  filter(!is.na(DTHADY)) %&gt;%\n  mutate(\n    ID = paste(SITEID, SUBJID, sep = \"/\"),\n    AGSXRC = paste(AGE, SEX, RACE, sep = \"/\"),\n    TRTSD = toupper(format(as.Date(TRTSDTM), \"%d%b%Y\"))\n  ) %&gt;%\n  arrange(SUBJID) %&gt;%\n  select(ID, AGSXRC, TRT01A, TRTSD, EOSDY, DTHADY, DTHCAUS, ADTHAUT)\n\nvar_labels(out) &lt;- c(\n  ID = \"Center/Patient ID\",\n  AGSXRC = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  TRTSD = \"Date of First\\nStudy Drug\\nAdministration\",\n  EOSDY = \"Day of Last\\nStudy Drug\\nAdministration\",\n  DTHADY = \"Day of\\nDeath\",\n  DTHCAUS = \"Cause of Death\",\n  ADTHAUT = \"Autopsy\\nPerformed?\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = \"ID\",\n  disp_cols = names(out),\n  main_title = \"Listing of Patient Deaths\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Patient Deaths\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                             Date of First     Day of Last                                              \n                                                                               Study Drug       Study Drug     Day of                          Autopsy  \nCenter/Patient ID               Age/Sex/Race                  Treatment      Administration   Administration   Death      Cause of Death      Performed?\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                   47/M/WHITE                   A: Drug X        04NOV2020           473          496        ADVERSE EVENT         Yes    \n  BRA-1/id-265                   25/M/WHITE                 C: Combination     07OCT2019           863          872           SUICIDE             No    \n   BRA-1/id-93                   34/F/ASIAN                   A: Drug X        20JUN2020           610          657        ADVERSE EVENT         Yes    \n  BRA-11/id-217                  43/M/ASIAN                   A: Drug X        28SEP2019           871          893        ADVERSE EVENT         Yes    \n   BRA-11/id-9                   40/M/ASIAN                 C: Combination     25MAR2019           1056         1091    DISEASE PROGRESSION      Yes    \n  BRA-14/id-120                  33/F/ASIAN                 C: Combination     19SEP2020           512          546        ADVERSE EVENT         Yes    \n  BRA-15/id-36                   38/F/ASIAN                   A: Drug X        08JAN2020           767          812     DISEASE PROGRESSION      Yes    \n  CAN-1/id-341                   43/F/ASIAN                   B: Placebo       23MAY2019           998          1013          SUICIDE            Yes    \n  CAN-11/id-139                  31/M/ASIAN                   A: Drug X        15SEP2020           519          563        ADVERSE EVENT         Yes    \n  CHN-1/id-123                   27/F/ASIAN                   A: Drug X        28JAN2020           750          750     DISEASE PROGRESSION      Yes    \n  CHN-1/id-156                   32/F/ASIAN                   B: Placebo       06SEP2020           528          542           SUICIDE             No    \n  CHN-1/id-199         27/M/BLACK OR AFRICAN AMERICAN         A: Drug X        08JAN2020           773          779     DISEASE PROGRESSION      Yes    \n  CHN-1/id-229      37/M/AMERICAN INDIAN OR ALASKA NATIVE     B: Placebo       13OCT2020           495          543     DISEASE PROGRESSION      Yes    \n  CHN-1/id-233         36/F/BLACK OR AFRICAN AMERICAN       C: Combination     11FEB2021           369          406           MISSING             NA    \n  CHN-1/id-235                   39/M/ASIAN                   A: Drug X        13JUL2019           950          968        ADVERSE EVENT         Yes    \n  CHN-1/id-307                   24/M/ASIAN                   B: Placebo       11MAR2019           1076         1121     LOST TO FOLLOW UP        NA    \n  CHN-1/id-346                   21/M/WHITE                   B: Placebo       23NOV2019           812          834        ADVERSE EVENT         Yes    \n   CHN-1/id-62                   36/F/WHITE                   A: Drug X        22NOV2020           455          497        ADVERSE EVENT         Yes    \n  CHN-10/id-380                  42/F/WHITE                   B: Placebo       09MAY2020           644          650        ADVERSE EVENT         Yes    \n  CHN-11/id-184                  38/F/ASIAN                 C: Combination     04MAY2019           1018         1029    DISEASE PROGRESSION      Yes    \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael02.html",
+    "href": "listings/adverse-events/ael02.html",
+    "title": "AEL02",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nout &lt;- adae %&gt;%\n  mutate(\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    Date_First = toupper(format(as.Date(TRTSDTM), \"%d%b%Y\")),\n    Duration = AENDY - ASTDY + 1,\n    Serious = ifelse(AESER == \"Y\", \"Yes\", ifelse(AESER == \"N\", \"No\", \"\")),\n    Related = ifelse(AEREL == \"Y\", \"Yes\", ifelse(AEREL == \"N\", \"No\", \"\")),\n    Outcome = case_when(\n      AEOUT == \"FATAL\" ~ 1,\n      AEOUT == \"NOT RECOVERED/NOT RESOLVED\" ~ 2,\n      AEOUT == \"RECOVERED/RESOLVED\" ~ 3,\n      AEOUT == \"RECOVERED/RESOLVED WITH SEQUELAE\" ~ 4,\n      AEOUT == \"RECOVERING/RESOLVING\" ~ 5,\n      AEOUT == \"UNKNOWN\" ~ 6\n    ),\n    Treated = ifelse(AECONTRT == \"Y\", \"Yes\", ifelse(AECONTRT == \"N\", \"No\", \"\")),\n    Action = case_when(\n      AEACN == \"DOSE INCREASED\" ~ 1,\n      AEACN == \"DOSE NOT CHANGED\" ~ 2,\n      AEACN == \"DOSE REDUCED\" | AEACN == \"DOSE RATE REDUCED\" ~ 3,\n      AEACN == \"DRUG INTERRUPTED\" ~ 4,\n      AEACN == \"DRUG WITHDRAWN\" ~ 5,\n      AEACN == \"NOT APPLICABLE\" | AEACN == \"NOT EVALUABLE\" ~ 6,\n      AEACN == \"UNKNOWN\" ~ 7\n    )\n  ) %&gt;%\n  select(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, Serious, AESEV, Related, Outcome, Treated, Action)\n\nvar_labels(out) &lt;- c(\n  CPID = \"Center/Patient ID\",\n  ASR = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  AEDECOD = \"Adverse\\nEvent MedDRA\\nPreferred Term\",\n  Date_First = \"Date of\\nFirst Study\\nDrug\\nAdministration\",\n  ASTDY = \"Study\\nDay of\\nOnset\",\n  Duration = \"AE\\nDuration\\nin Days\",\n  Serious = \"Serious\",\n  AESEV = \"Most\\nExtreme\\nIntensity\",\n  Related = \"Caused by\\nStudy\\nDrug\",\n  Outcome = \"Outcome\\n(1)\",\n  Treated = \"Treatment\\nfor AE\",\n  Action = \"Action\\nTaken\\n(2)\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CPID\", \"ASR\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Adverse Events\",\n  main_footer = \"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =\n    recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\"\n)\n\nhead(lsting, 20)\n\nListing of Adverse Events\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                          Date of                                                                                         \n                                                                         Adverse        First Study     Study       AE                  Most      Caused by                         Action\n                                                                       Event MedDRA         Drug        Day of   Duration              Extreme      Study     Outcome   Treatment   Taken \nCenter/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Administration   Onset    in Days    Serious   Intensity     Drug        (1)      for AE      (2)  \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd B.2.1.2.1      04NOV2020       162       173        No      MODERATE       No          5         Yes        2   \n                                                                      dcd D.1.1.4.2      04NOV2020       196       166        No      MODERATE       No          5         No         2   \n                                                                      dcd A.1.1.1.2      04NOV2020       321       149        Yes     MODERATE       No          5         Yes        2   \n                                                                      dcd A.1.1.1.2      04NOV2020       393        43        Yes     MODERATE       No          5         No         5   \n  BRA-1/id-141                35/F/WHITE             C: Combination   dcd B.2.1.2.1      25JUL2020       387        11        No      MODERATE       No          3         Yes        1   \n                                                                      dcd D.2.1.5.3      25JUL2020       455       628        No        MILD         Yes         3         No         1   \n                                                                      dcd A.1.1.1.1      25JUL2020       739        36        No        MILD         No          4         Yes        3   \n                                                                      dcd A.1.1.1.2      25JUL2020       899       139        Yes     MODERATE       No          4         Yes        2   \n                                                                      dcd A.1.1.1.1      25JUL2020       951        66        No        MILD         No          5         No         1   \n                                                                      dcd D.1.1.1.1      25JUL2020       1093       3         Yes      SEVERE        Yes         1         No         6   \n  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JAN2021        33       614        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd B.1.1.1.1      15JAN2021       271       775        Yes      SEVERE        Yes         1         Yes        6   \n                                                                      dcd B.1.1.1.1      15JAN2021       1051       7         Yes      SEVERE        Yes         1         Yes        6   \n  BRA-1/id-265                25/M/WHITE             C: Combination   dcd C.2.1.2.1      07OCT2019        84        78        No      MODERATE       Yes         2         Yes        5   \n                                                                      dcd D.1.1.4.2      07OCT2019       349       285        No      MODERATE       No          3         Yes        7   \n                                                                      dcd D.1.1.1.1      07OCT2019       685        37        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd C.1.1.1.3      07OCT2019       705        66        No       SEVERE        Yes         4         Yes        7   \n   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd C.2.1.2.1      01JAN2020        39       506        No      MODERATE       Yes         2         No         6   \n                                                                      dcd D.1.1.1.1      01JAN2020        64       630        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd C.2.1.2.1      01JAN2020        95       306        No      MODERATE       Yes         5         No         2   \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =\n    recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael01.html",
+    "href": "listings/adverse-events/ael01.html",
+    "title": "AEL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nout &lt;- adae %&gt;%\n  select(AESOC, AEDECOD, AELLT, AETERM) %&gt;%\n  unique()\n\nvar_labels(out) &lt;- c(\n  AESOC = \"MedDRA System Organ Class\",\n  AEDECOD = \"MedDRA Preferred Term\",\n  AELLT = \"MedDRA Lowest Level Term\",\n  AETERM = \"Investigator-Specified\\nAdverse Event Term\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"AESOC\", \"AEDECOD\", \"AELLT\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms\n\n—————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                               Investigator-Specified\nMedDRA System Organ Class   MedDRA Preferred Term   MedDRA Lowest Level Term     Adverse Event Term  \n—————————————————————————————————————————————————————————————————————————————————————————————————————\n          cl A                  dcd A.1.1.1.1            llt A.1.1.1.1             trm A.1.1.1.1     \n                                dcd A.1.1.1.2            llt A.1.1.1.2             trm A.1.1.1.2     \n          cl B                  dcd B.1.1.1.1            llt B.1.1.1.1             trm B.1.1.1.1     \n                                dcd B.2.1.2.1            llt B.2.1.2.1             trm B.2.1.2.1     \n                                dcd B.2.2.3.1            llt B.2.2.3.1             trm B.2.2.3.1     \n          cl C                  dcd C.1.1.1.3            llt C.1.1.1.3             trm C.1.1.1.3     \n                                dcd C.2.1.2.1            llt C.2.1.2.1             trm C.2.1.2.1     \n          cl D                  dcd D.1.1.1.1            llt D.1.1.1.1             trm D.1.1.1.1     \n                                dcd D.1.1.4.2            llt D.1.1.4.2             trm D.1.1.4.2     \n                                dcd D.2.1.5.3            llt D.2.1.5.3             trm D.2.1.5.3     \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/ECG/egl01.html",
+    "href": "listings/ECG/egl01.html",
+    "title": "EGL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\nget_param_unit_range &lt;- function(dataset) {\n  u_rng &lt;- lapply(unique(dataset$PARAMCD), function(p) {\n    dat &lt;- dataset %&gt;% filter(PARAMCD == p)\n    list(\n      unit = unique(dat$AVALU),\n      range = paste0(unique(dat$ANRLO), \"-\", unique(dat$ANRHI))\n    )\n  })\n  names(u_rng) &lt;- unique(dataset$PARAMCD)\n  u_rng\n}\n\neg_u_rng &lt;- get_param_unit_range(adeg)\n\nadeg_sub &lt;- adeg %&gt;%\n  filter(!is.na(AVAL) & SAFFL == \"Y\" & ANL01FL == \"Y\" & !is.na(EGSEQ) & PARAMCD != \"ECGINTP\") %&gt;%\n  mutate(\n    CRTNPT = paste(SITEID, sub(\"^.*-([[:alnum:]]+)$\", \"\\\\1\", SUBJID), sep = \"/\"),\n    AGSXRC = paste(AGE, SEX, RACE, sep = \"/\"),\n    AVAL = format(round(AVAL, 2), nsmall = 2),\n    AVAL_ANRIND = ifelse(ANRIND %in% c(\"NORMAL\", \"\"), AVAL, paste(AVAL, substr(ANRIND, 1, 1), sep = \"/\")),\n    CHG = format(round(CHG, 2), nsmall = 2)\n  )\n\nanl_eg &lt;- adeg_sub %&gt;%\n  select(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),\n    names_from = PARAMCD,\n    values_from = c(AVAL_ANRIND, CHG)\n  )\n\nout &lt;- anl_eg %&gt;%\n  select(CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_HR, CHG_HR, AVAL_ANRIND_QT, CHG_QT, AVAL_ANRIND_RR, CHG_RR) %&gt;%\n  var_relabel(\n    CRTNPT = \"Center/Subject ID\",\n    AGSXRC = \"Age/Sex/Race\",\n    TRT01A = \"Treatment\",\n    AVISIT = \"Visit\",\n    ADY = \"Study\\nDay\",\n    AVAL_ANRIND_HR = paste0(\"Heart Rate Result\\n(\", eg_u_rng$HR$unit, \");\\nRange:(\", eg_u_rng$HR$range, \")\"),\n    CHG_HR = \"Heart Rate\\nChange from BL\",\n    AVAL_ANRIND_QT = paste0(\"QT Duration Result\\n(\", eg_u_rng$QT$unit, \");\\nRange:(\", eg_u_rng$QT$range, \")\"),\n    CHG_QT = \"QT Duration\\nChange from BL\",\n    AVAL_ANRIND_RR = paste0(\"RR Duration Result\\n(\", eg_u_rng$RR$unit, \");\\nRange:(\", eg_u_rng$RR$range, \")\"),\n    CHG_RR = \"RR Duration\\nChange from BL\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CRTNPT\", \"AGSXRC\", \"TRT01A\", \"AVISIT\", \"ADY\"),\n  disp_cols = names(out),\n  main_title = \"Listing of ECG Data: Safety-Evaluable Patients\",\n  main_footer = \"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if\n  outside the Roche standard reference range.\"\n)\n\nhead(lsting, 20)\n\nListing of ECG Data: Safety-Evaluable Patients\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                              Heart Rate Result                    QT Duration Result                    RR Duration Result                 \n                                                                                      Study     (beats/min);        Heart Rate          (msec);          QT Duration          (msec);          RR Duration  \nCenter/Subject ID            Age/Sex/Race              Treatment          Visit        Day     Range:(40-100)     Change from BL    Range:(200-500)     Change from BL    Range:(600-1500)    Change from BL\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n    BRA-1/105       38/M/BLACK OR AFRICAN AMERICAN     A: Drug X        BASELINE       149          66.94               NA               441.78               NA               896.59               NA      \n                                                                      WEEK 1 DAY 8     314          63.18             -3.76              365.68             -76.10            1376.26             479.67    \n                                                                      WEEK 2 DAY 15    398          57.57             -9.37              355.48             -86.29             799.57             -97.02    \n                                                                      WEEK 3 DAY 22    470          73.36              6.42              352.45             -89.33            1015.00             118.41    \n                                                                      WEEK 4 DAY 29    528          53.72             -13.22             388.42             -53.36            1189.29             292.70    \n                                                                      WEEK 5 DAY 36    535          58.25             -8.69              291.77            -150.01             936.09             39.50     \n    BRA-1/134                 47/M/WHITE               A: Drug X        BASELINE       227          46.99               NA               385.29               NA               835.17               NA      \n                                                                      WEEK 1 DAY 8     255          48.38              1.39              453.74             68.46              901.86             66.68     \n                                                                      WEEK 2 DAY 15    269         35.40/L            -11.59             413.54             28.26              892.01             56.84     \n                                                                      WEEK 3 DAY 22    357          60.50             13.51              394.23              8.95             490.18/L           -344.99    \n                                                                      WEEK 4 DAY 29    436          82.28             35.29              398.29             13.00              757.96             -77.21    \n                                                                      WEEK 5 DAY 36    440         38.89/L            -8.10              339.38             -45.91             880.26             45.08     \n    BRA-1/141                 35/F/WHITE             C: Combination     BASELINE       52           92.83               NA               302.14               NA              1436.04               NA      \n                                                                      WEEK 1 DAY 8     189          67.20             -25.63            197.02/L           -105.11             988.48            -447.56    \n                                                                      WEEK 2 DAY 15    262          71.22             -21.60             255.81             -46.33            1494.56             58.52     \n                                                                      WEEK 3 DAY 22    386          71.39             -21.44             245.22             -56.92            1193.28            -242.76    \n                                                                      WEEK 4 DAY 29    425          69.49             -23.34             369.92             67.78              976.32            -459.72    \n                                                                      WEEK 5 DAY 36    730          81.26             -11.56            199.68/L           -102.45             779.76            -656.28    \n    BRA-1/236       32/M/BLACK OR AFRICAN AMERICAN     B: Placebo       BASELINE       275          88.84               NA               418.61               NA             1608.46/H              NA      \n                                                                      WEEK 1 DAY 8     431         34.23/L            -54.61             449.83             31.21             1148.53            -459.93    \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nBaseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if\n  outside the Roche standard reference range.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/pharmacokinetic/pkcl01.html",
+    "href": "listings/pharmacokinetic/pkcl01.html",
+    "title": "PKCL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(rlistings)\nlibrary(scda)\nlibrary(dplyr)\n\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\")\n\nanalyte &lt;- \"Plasma Drug X\"\n\nout &lt;- adpc %&gt;%\n  filter(PARAM == analyte) %&gt;%\n  select(ARM, USUBJID, VISIT, NFRLT, AFRLT, AVAL)\n\nvar_labels(out) &lt;- c(\n  ARM = \"Treatment Group\",\n  USUBJID = \"Subject ID\",\n  VISIT = \"Visit\",\n  NFRLT = paste0(\"Nominal Sampling\\nTime (\", adpc$RELTMU[1], \")\"),\n  AFRLT = paste0(\"Actual Time\\nFrom First\\nDose (\", adpc$RELTMU[1], \")\"),\n  AVAL = paste0(\"Concentration\\n(\", adpc$AVALU[1], \")\")\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ARM\", \"USUBJID\", \"VISIT\"),\n  disp_cols = names(out),\n  main_title = paste(\"Listing of\", analyte, \"Concentration by Treatment Group, Subject and Nominal Time, PK Population\\nProtocol: xxnnnnn\"),\n  subtitles = paste(\"Analyte:\", analyte)\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Plasma Drug X Concentration by Treatment Group, Subject and Nominal Time, PK Population\nProtocol: xxnnnnn\nAnalyte: Plasma Drug X\n\n———————————————————————————————————————————————————————————————————————————————————————————————\n                                                                    Actual Time                \n                                                 Nominal Sampling   From First    Concentration\nTreatment Group        Subject ID        Visit      Time (hr)        Dose (hr)       (ug/mL)   \n———————————————————————————————————————————————————————————————————————————————————————————————\n   A: Drug X      AB12345-BRA-1-id-105   Day 1          0                0              0      \n                                                       0.5              0.5          10.404    \n                                                        1                1           13.987    \n                                                       1.5              1.5          14.142    \n                                                        2                2           12.744    \n                                                        3                3            8.803    \n                                                        4                4            5.461    \n                                                        8                8            0.562    \n                                                        12              12            0.049    \n                                         Day 2          24              24              0      \n                  AB12345-BRA-1-id-134   Day 1          0                0              0      \n                                                       0.5              0.5          14.405    \n                                                        1                1           17.863    \n                                                       1.5              1.5          16.613    \n                                                        2                2           13.735    \n                                                        3                3            7.923    \n                                                        4                4            4.064    \n                                                        8                8            0.178    \n                                                        12              12            0.006    \n                                         Day 2          24              24              0      \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      scda_0.1.6       rlistings_0.2.4  tibble_3.2.1    \n[5] formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/pharmacokinetic/pkpl02.html",
+    "href": "listings/pharmacokinetic/pkpl02.html",
+    "title": "PKPL02",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(rlistings)\nlibrary(scda)\n\ndrug_a &lt;- \"Plasma Drug X\"\nspec &lt;- \"Urine\"\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp_x &lt;- adpp %&gt;% filter(\n  PPCAT == drug_a,\n  PPSPEC == spec\n)\n\nout &lt;- adpp_x %&gt;%\n  mutate(PARAM = paste0(PARAM, \" (\", AVALU, \")\")) %&gt;%\n  select(TRT01A, USUBJID, AVISIT, PARAM, AVAL) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(TRT01A, USUBJID, AVISIT),\n    names_from = PARAM,\n    values_from = AVAL\n  )\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;% var_relabel(\n  TRT01A = \"Treatment Group\",\n  USUBJID = \"Subject ID\",\n  AVISIT = \"Visit\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"TRT01A\", \"USUBJID\", \"AVISIT\"),\n  disp_cols = names(out),\n  main_title = paste(\"Listing of\", drug_a, spec, \"PK Parameters, PK Population\\nProtocol: xxnnnnn\"),\n  subtitles = paste(\"Analyte:\", drug_a)\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Plasma Drug X Urine PK Parameters, PK Population\nProtocol: xxnnnnn\nAnalyte: Plasma Drug X\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Group        Subject ID             Visit        Renal CL (L/hr)     Renal CL Norm by Dose (L/hr/mg)   Amt Rec from T1 to T2 (mg)   Pct Rec from T1 to T2 (%)\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   A: Drug X      AB12345-BRA-1-id-105      SCREENING     0.0538423152160391         0.00441769893771616              2.15210785813109            17.8220657702531     \n                                          CYCLE 1 DAY 1   0.0480828455497337         0.00418360874479016              1.77968465488986            13.4821873677008     \n                                          CYCLE 1 DAY 2   0.0524191320174391         0.00574562025709617              1.7751362634173             11.7748899262287     \n                  AB12345-BRA-1-id-134      SCREENING     0.054828756388858          0.00489378524965625              1.69069405572207            14.6782255303037     \n                                          CYCLE 1 DAY 1   0.0463628883891636         0.00281388401660215              1.03364773182262            15.2049132671477     \n                                          CYCLE 1 DAY 2   0.0542853013687975         0.00480239019141706              2.07978470495693            16.6499332185177     \n                   AB12345-BRA-1-id-42      SCREENING     0.0479776607513692         0.00620670551445586              1.49259200502984            12.4632371401908     \n                                          CYCLE 1 DAY 1   0.060136833920038          0.00423749524975822               2.002399829348             16.1228873656652     \n                                          CYCLE 1 DAY 2   0.0222050225259149         0.0041513339034891               1.65173021070619             10.129985981426     \n                   AB12345-BRA-1-id-93      SCREENING     0.0429283028076499         0.00450841008626937             0.882348047230192            19.8088728992851     \n                                          CYCLE 1 DAY 1   0.0343747382858835         0.00495342578722049              1.73500915591676            14.8733500411057     \n                                          CYCLE 1 DAY 2   0.0474831008867497         0.00415970555107753              1.30298887256052            14.9616973312841     \n                  AB12345-BRA-11-id-217     SCREENING     0.0524432563610182         0.00439177770746837              1.16344390767412             16.584779611686     \n                                          CYCLE 1 DAY 1   0.0411628011374518         0.00567801310981526              1.11763922430636            19.3000982041101     \n                                          CYCLE 1 DAY 2   0.0672581292323284         0.00400060865194939              1.45655867480937            10.1596117673893     \n                  AB12345-BRA-11-id-345     SCREENING     0.044070189259969          0.00561835429596993              1.43739076299198            15.4875095868721     \n                                          CYCLE 1 DAY 1   0.0362275034574886         0.0038765297501434                0.96604915921              17.1567306808389     \n                                          CYCLE 1 DAY 2   0.0416331541840018         0.00462187415243145              1.27070193721417            19.2547757988484     \n                  AB12345-BRA-11-id-397     SCREENING     0.0379747899730378         0.0047876948377162               1.67729762147252            11.6015615292251     \n                                          CYCLE 1 DAY 1   0.0430467407701829         0.00463308440642305              1.1695965192594             12.5511219923965     \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/concomitant-medications/cml02a_gl.html",
+    "href": "listings/concomitant-medications/cml02a_gl.html",
+    "title": "CML02A_GL",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nout &lt;- adcm %&gt;%\n  select(ATC2, CMDECOD, CMTRT) %&gt;%\n  unique()\n\nvar_labels(out) &lt;- c(\n  ATC2 = \"ATC Class Level 2\",\n  CMDECOD = \"WHODrug Preferred Name\",\n  CMTRT = \"Investigator-Specified\\nTreatment Term\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ATC2\", \"CMDECOD\", \"CMTRT\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms\n\n———————————————————————————————————————————————————————————————————\n                                             Investigator-Specified\nATC Class Level 2   WHODrug Preferred Name       Treatment Term    \n———————————————————————————————————————————————————————————————————\n   ATCCLAS2 A           medname A_1/3                A_1/3         \n                        medname A_2/3                A_2/3         \n                        medname A_3/3                A_3/3         \n  ATCCLAS2 A p2         medname A_3/3                A_3/3         \n   ATCCLAS2 B           medname B_1/4                B_1/4         \n                        medname B_2/4                B_2/4         \n                        medname B_3/4                B_3/4         \n                        medname B_4/4                B_4/4         \n  ATCCLAS2 B p2         medname B_1/4                B_1/4         \n                        medname B_2/4                B_2/4         \n  ATCCLAS2 B p3         medname B_1/4                B_1/4         \n                        medname B_2/4                B_2/4         \n   ATCCLAS2 C           medname C_1/2                C_1/2         \n                        medname C_2/2                C_2/2         \n  ATCCLAS2 C p2         medname C_1/2                C_1/2         \n                        medname C_2/2                C_2/2         \n  ATCCLAS2 C p3         medname C_2/2                C_2/2         \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/concomitant-medications/cml02b_gl.html",
+    "href": "listings/concomitant-medications/cml02b_gl.html",
+    "title": "CML02B_GL",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nout &lt;- adcm %&gt;%\n  select(ATC1, ATC2, ATC3, ATC4, CMDECOD, CMTRT) %&gt;%\n  unique()\n\nvar_labels(out) &lt;- c(\n  ATC1 = \"ATC Class Level 1\",\n  ATC2 = \"ATC Class Level 2\",\n  ATC3 = \"ATC Class Level 3\",\n  ATC4 = \"ATC Class Level 4\",\n  CMDECOD = \"WHODrug Preferred Name\",\n  CMTRT = \"Investigator-Specified\\nTreatment Term\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\", \"CMDECOD\", \"CMTRT\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                         Investigator-Specified\nATC Class Level 1   ATC Class Level 2   ATC Class Level 3   ATC Class Level 4   WHODrug Preferred Name       Treatment Term    \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   ATCCLAS1 A          ATCCLAS2 A          ATCCLAS3 A          ATCCLAS4 A           medname A_1/3                A_1/3         \n                                                                                    medname A_2/3                A_2/3         \n                                                                                    medname A_3/3                A_3/3         \n  ATCCLAS1 A p2       ATCCLAS2 A p2       ATCCLAS3 A p2       ATCCLAS4 A p2         medname A_3/3                A_3/3         \n   ATCCLAS1 B          ATCCLAS2 B          ATCCLAS3 B          ATCCLAS4 B           medname B_1/4                B_1/4         \n                                                                                    medname B_2/4                B_2/4         \n                                                                                    medname B_3/4                B_3/4         \n                                                                                    medname B_4/4                B_4/4         \n  ATCCLAS1 B p2       ATCCLAS2 B p2       ATCCLAS3 B p2       ATCCLAS4 B p2         medname B_1/4                B_1/4         \n                                                                                    medname B_2/4                B_2/4         \n  ATCCLAS1 B p3       ATCCLAS2 B p3       ATCCLAS3 B p3       ATCCLAS4 B p3         medname B_1/4                B_1/4         \n                                                                                    medname B_2/4                B_2/4         \n   ATCCLAS1 C          ATCCLAS2 C          ATCCLAS3 C          ATCCLAS4 C           medname C_1/2                C_1/2         \n                                                                                    medname C_2/2                C_2/2         \n  ATCCLAS1 C p2       ATCCLAS2 C p2       ATCCLAS3 C p2       ATCCLAS4 C p2         medname C_1/2                C_1/2         \n                                                                                    medname C_2/2                C_2/2         \n  ATCCLAS1 C p3       ATCCLAS2 C p3       ATCCLAS3 C p3       ATCCLAS4 C p3         medname C_2/2                C_2/2         \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/efficacy/oncl01.html",
+    "href": "listings/efficacy/oncl01.html",
+    "title": "ONCL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadrs &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\nout_ex &lt;- adex %&gt;%\n  filter(PARAMCD == \"TNDOSE\") %&gt;%\n  mutate(ID = paste(SITEID, SUBJID, sep = \"/\")) %&gt;%\n  select(ID, AVAL)\n\nout_rs &lt;- adrs %&gt;%\n  filter(PARAM %in% c(\"Investigator End Of Induction Response\", \"Best Confirmed Overall Response by Investigator\")) %&gt;%\n  mutate(ID = paste(SITEID, SUBJID, sep = \"/\")) %&gt;%\n  select(ID, AVALC, PARAM) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = ID,\n    names_from = PARAM,\n    values_from = AVALC\n  ) %&gt;%\n  right_join(out_ex, ., by = \"ID\", multiple = \"all\")\n\nadtte_flt &lt;- adtte %&gt;%\n  filter(PARAMCD %in% c(\"OS\", \"PFS\", \"CRSD\")) %&gt;%\n  mutate(\n    PARAM = paste(PARAM, paste0(\"(\", AVALU, \")\"), sep = \" \"), ID = paste(SITEID, SUBJID, sep = \"/\"),\n    trigeventpfs = ifelse(CNSR == 0, EVNTDESC, NA)\n  )\n\n# Select triggering event variable\nout_trg &lt;- adtte_flt %&gt;%\n  select(ID, trigeventpfs)\n\nout_tte &lt;- adtte_flt %&gt;%\n  select(ID, TRT01A, PARAM, AVAL, trigeventpfs) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(ID, TRT01A),\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate_at(\n    c(\"Overall Survival (DAYS)\", \"Progression Free Survival (DAYS)\", \"Duration of Confirmed Response (DAYS)\"),\n    function(x) format(round(x, 1), nsmall = 1)\n  ) %&gt;%\n  select(ID, TRT01A, `Overall Survival (DAYS)`, `Progression Free Survival (DAYS)`, `Duration of Confirmed Response (DAYS)`) %&gt;%\n  right_join(out_trg, ., by = \"ID\", multiple = \"all\")\n\nout &lt;- out_tte %&gt;%\n  right_join(out_rs, ., by = \"ID\", multiple = \"all\") %&gt;%\n  select(\n    \"ID\", \"TRT01A\", \"AVAL\", \"Best Confirmed Overall Response by Investigator\", \"Investigator End Of Induction Response\", \"Overall Survival (DAYS)\",\n    \"Progression Free Survival (DAYS)\", \"trigeventpfs\", \"Duration of Confirmed Response (DAYS)\"\n  )\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    ID = \"Center/Patient ID\",\n    TRT01A = \"Treatment\",\n    AVAL = \"Number of Doses\\nReceived\",\n    `Best Confirmed Overall Response by Investigator` = \"Best Confirmed\\nOverall Response\\nby Investigator\",\n    `Investigator End Of Induction Response` = \"Investigator\\nEnd Of Induction\\nResponse\",\n    trigeventpfs = \"Triggering Event\\n for PFS\",\n    `Overall Survival (DAYS)` = \"Overall Survival\\n(days)\",\n    `Progression Free Survival (DAYS)` = \"PFS\\n(days)\",\n    `Duration of Confirmed Response (DAYS)` = \"Duration of\\nConfirmed Response\\n(days)\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ID\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Individual Efficacy Data\",\n  main_footer = \"PFS = Progression Free Survival\"\n)\n\nhead(lsting, 20)\n\nListing of Individual Efficacy Data\n\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                        Best Confirmed      Investigator                                                          Duration of    \n                                     Number of Doses   Overall Response   End Of Induction   Overall Survival    PFS      Triggering Event     Confirmed Response\nCenter/Patient ID     Treatment         Received       by Investigator        Response            (days)        (days)         for PFS               (days)      \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-105        A: Drug X             7                 CR                 CR               402.6         235.7    Disease Progression         119.6       \n                                            7                 CR                 CR               402.6         235.7            NA                  119.6       \n                                            7                 CR                 CR               402.6         235.7            NA                  119.6       \n  BRA-1/id-134        A: Drug X             7                 CR                 CR                90.1          90.1           Death                 90.1       \n                                            7                 CR                 CR                90.1          90.1           Death                 90.1       \n                                            7                 CR                 CR                90.1          90.1           Death                 90.1       \n  BRA-1/id-141      C: Combination          7                 CR                 PR               422.9         216.3            NA                  123.0       \n                                            7                 CR                 PR               422.9         216.3            NA                  123.0       \n                                            7                 CR                 PR               422.9         216.3            NA                  123.0       \n  BRA-1/id-236        B: Placebo            7                 PR                 SD               240.8         240.8            NA                  118.8       \n                                            7                 PR                 SD               240.8         240.8           Death                118.8       \n                                            7                 PR                 SD               240.8         240.8           Death                118.8       \n  BRA-1/id-265      C: Combination          7                 CR                 PD               130.9         130.9           Death                130.9       \n                                            7                 CR                 PD               130.9         130.9           Death                130.9       \n                                            7                 CR                 PD               130.9         130.9           Death                130.9       \n   BRA-1/id-42        A: Drug X             7                 PR                 PR               407.0         204.6    Disease Progression         193.9       \n                                            7                 PR                 PR               407.0         204.6            NA                  193.9       \n                                            7                 PR                 PR               407.0         204.6            NA                  193.9       \n   BRA-1/id-65        B: Placebo            7                 PR                 SD               332.6         288.1            NA                  190.6       \n                                            7                 PR                 SD               332.6         288.1            NA                  190.6       \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nPFS = Progression Free Survival\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "index.html#introduction",
+    "href": "index.html#introduction",
+    "title": "TLG Catalog",
+    "section": "Introduction",
+    "text": "Introduction\nA catalog of Tables, Listings, and Graphs output produced by NEST tools.\nSee the full index of available TLG templates on the Index page."
+  },
+  {
+    "objectID": "index.html#license",
+    "href": "index.html#license",
+    "title": "TLG Catalog",
+    "section": "License",
+    "text": "License\nThis catalog as well as code examples are licensed under the Apache License, Version 2.0."
+  },
+  {
+    "objectID": "listings/vital-signs/vsl01.html",
+    "href": "listings/vital-signs/vsl01.html",
+    "title": "VSL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\n\nget_param_unit_range &lt;- function(dataset) {\n  u_rng &lt;- lapply(unique(dataset$PARAMCD), function(p) {\n    dat &lt;- dataset %&gt;% filter(PARAMCD == p)\n    list(\n      unit = unique(dat$AVALU),\n      range = paste0(unique(dat$ANRLO), \"-\", unique(dat$ANRHI))\n    )\n  })\n  names(u_rng) &lt;- unique(dataset$PARAMCD)\n  u_rng\n}\n\nvs_u_rng &lt;- get_param_unit_range(advs)\n\nadvs_sub &lt;- advs %&gt;%\n  filter(!is.na(AVAL) & SAFFL == \"Y\" & ONTRTFL == \"Y\" & !is.na(VSSEQ)) %&gt;%\n  mutate(\n    CRTNPT = paste(SITEID, sub(\"^.*-([[:alnum:]]+)$\", \"\\\\1\", SUBJID), sep = \"/\"),\n    AGSXRC = paste(AGE, SEX, RACE, sep = \"/\"),\n    AVAL = format(round(AVAL, 2), nsmall = 2),\n    AVAL_ANRIND = ifelse(ANRIND %in% c(\"NORMAL\", \"\"), AVAL, paste(AVAL, substr(ANRIND, 1, 1), sep = \"/\")),\n    CHG = format(round(CHG, 2), nsmall = 2)\n  )\n\nanl_vs &lt;- advs_sub %&gt;%\n  select(SUBJID, CRTNPT, AGSXRC, TRT01A, PARAMCD, AVAL_ANRIND, CHG, ADY, AVISIT, ADTM) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(SUBJID, CRTNPT, AGSXRC, TRT01A, ADY, AVISIT, ADTM),\n    names_from = PARAMCD,\n    values_from = c(AVAL_ANRIND, CHG)\n  )\n\nout &lt;- anl_vs %&gt;%\n  select(\n    CRTNPT, AGSXRC, TRT01A, AVISIT, ADY, AVAL_ANRIND_WEIGHT, CHG_WEIGHT, AVAL_ANRIND_TEMP, CHG_TEMP, AVAL_ANRIND_DIABP,\n    CHG_DIABP, AVAL_ANRIND_SYSBP, CHG_SYSBP, AVAL_ANRIND_PULSE, CHG_PULSE, AVAL_ANRIND_RESP, CHG_RESP\n  ) %&gt;%\n  var_relabel(\n    CRTNPT = \"Center/Subject ID\",\n    AGSXRC = \"Age/Sex/Race\",\n    TRT01A = \"Treatment\",\n    AVISIT = \"Visit\",\n    ADY = \"Study\\nDay\",\n    AVAL_ANRIND_WEIGHT = paste0(\"Weight\\nResult\\n(\", vs_u_rng$WEIGHT$unit, \");\\nRange:(\", vs_u_rng$WEIGHT$range, \")\"),\n    CHG_WEIGHT = \"Weight\\nChange from BL\",\n    AVAL_ANRIND_TEMP = paste0(\"Temperature Result\\n(\", vs_u_rng$TEMP$unit, \");\\nRange:(\", vs_u_rng$TEMP$range, \")\"),\n    CHG_TEMP = \"Temperature Rate\\nChange from BL\",\n    AVAL_ANRIND_DIABP = paste0(\"Diastolic Blood\\nPressure,\\nSitting\\nResult\\n(\", vs_u_rng$DIABP$unit, \");\\nRange:(\", vs_u_rng$DIABP$range, \")\"),\n    CHG_DIABP = \"Diastolic Blood\\nPressure,\\nSitting\\nChange from BL\",\n    AVAL_ANRIND_SYSBP = paste0(\"Systolic Blood\\nPressure,\\nSitting\\n(\", vs_u_rng$SYSBP$unit, \");\\nRange:(\", vs_u_rng$SYSBP$range, \")\"),\n    CHG_SYSBP = \"Systolic Blood\\nPressure,\\nSitting\\nChange from BL\",\n    AVAL_ANRIND_PULSE = paste0(\"Pulse Rate Result\\n(\", vs_u_rng$PULSE$unit, \");\\nRange:(\", vs_u_rng$PULSE$range, \")\"),\n    CHG_PULSE = \"Pulse Rate\\nChange from BL\",\n    AVAL_ANRIND_RESP = paste0(\"Respiratory Rate\\nResult\\n(\", vs_u_rng$RESP$unit, \");\\nRange:(\", vs_u_rng$RESP$range, \")\"),\n    CHG_RESP = \"Respiratory Rate\\nChange from BL\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CRTNPT\", \"AGSXRC\", \"TRT01A\", \"AVISIT\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Vital Signs: Safety-Evaluable Patients\",\n  main_footer = \"Baseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if\n  outside the Roche standard reference range.\"\n)\n\nhead(lsting, 20)\n\nListing of Vital Signs: Safety-Evaluable Patients\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                                                                                        Diastolic Blood                                                                                                                                \n                                                                                                                                                                           Pressure,                        Systolic Blood                                                                                             \n                                                                                                  Weight                                                                    Sitting       Diastolic Blood      Pressure,      Systolic Blood                                        Respiratory Rate                   \n                                                                                                  Result                        Temperature Result                          Result           Pressure,          Sitting         Pressure,      Pulse Rate Result                         Result                        \n                                                                                      Study       (Kg);            Weight              (C);          Temperature Rate        (Pa);            Sitting            (Pa);           Sitting         (beats/min);        Pulse Rate      (breaths/min);    Respiratory Rate\nCenter/Subject ID            Age/Sex/Race              Treatment          Visit        Day    Range:(40-100)   Change from BL   Range:(36.1-37.2)     Change from BL    Range:(80-120)    Change from BL    Range:(120-180)   Change from BL    Range:(60-100)     Change from BL    Range:(12-20)      Change from BL \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n    BRA-1/105       38/M/BLACK OR AFRICAN AMERICAN     A: Drug X      WEEK 1 DAY 8     189        90.96            24.62              36.79               -1.88             101.10            -12.65           181.05/H            3.70              84.91             -2.05             18.34               1.13      \n                                                                      WEEK 2 DAY 15    323        41.40            -24.93             36.52               -2.14             111.02             -2.72            132.47            -44.88             71.54             -15.42            9.81/L             -7.40      \n                                                                      WEEK 3 DAY 22    492        60.55            -5.78             35.03/L              -3.64              88.35            -25.39           112.67/L           -64.68            33.75/L            -53.22           21.23/H              4.02      \n                                                                      WEEK 4 DAY 29    550        69.69             3.36             35.71/L              -2.95             100.74            -13.00           194.88/H           17.53              97.51             10.54             12.50              -4.71      \n                                                                      WEEK 5 DAY 36    628        81.64            15.30             36.01/L              -2.65            123.17/H            9.43             140.33            -37.02             62.50             -24.47           10.91/L             -6.30      \n    BRA-1/134                 47/M/WHITE               A: Drug X      WEEK 1 DAY 8     203        42.95            -12.51             36.39               -1.38             112.71             26.38            148.69            -52.75             69.12              3.72             15.31              -2.84      \n                                                                      WEEK 2 DAY 15    326       20.36/L           -35.09            35.75/L              -2.03              98.42             12.09           188.08/H           -13.36             68.79              3.40             17.60              -0.55      \n                                                                      WEEK 3 DAY 22    363        46.33            -9.12             35.43/L              -2.34              97.88             11.55            160.05            -41.39             90.21             24.81             18.15               0.00      \n                                                                      WEEK 4 DAY 29    367        43.83            -11.62            36.01/L              -1.76              98.97             12.65            132.19            -69.25             88.39             23.00             19.62               1.48      \n                                                                      WEEK 5 DAY 36    417       31.75/L           -23.71             36.35               -1.42            124.26/H            37.94            134.30            -67.14             88.64             23.25            20.08/H              1.94      \n    BRA-1/141                 35/F/WHITE             C: Combination   WEEK 1 DAY 8     515        65.32             9.22              36.72               -0.29              81.16            -48.30            73.44/L           -63.33             99.83             23.51            21.66/H             10.64      \n                                                                      WEEK 2 DAY 15    764        87.53            31.44             37.68/H               0.67             110.55            -18.90            172.75            35.98            114.23/H            37.92             16.13               5.10      \n                                                                      WEEK 3 DAY 22    814        69.69            13.59             38.39/H               1.38             69.94/L           -59.52            155.35            18.58              88.12             11.80             15.31               4.29      \n                                                                      WEEK 4 DAY 29    844        74.64            18.54              36.62               -0.40              84.59            -44.87            156.15            19.38              71.44             -4.87             12.20               1.18      \n                                                                      WEEK 5 DAY 36    914       39.39/L           -16.71             36.81               -0.21             102.02            -27.44            135.87            -0.90              68.75             -7.56             9.76/L             -1.26      \n    BRA-1/236       32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     WEEK 1 DAY 8     486       37.04/L           -0.79              36.11                0.27            120.31/H            11.74            146.04            -5.09              65.75             -3.33            22.69/H              3.96      \n                                                                      WEEK 2 DAY 15    678        80.66            42.83             35.64/L              -0.21             106.20             -2.37            146.80            -4.32              82.04             12.96             16.89              -1.84      \n                                                                      WEEK 3 DAY 22    762        86.71            48.88              36.16                0.32             104.63             -3.94            76.01/L           -75.12             70.13              1.05             19.70               0.97      \n                                                                      WEEK 4 DAY 29    773        48.43            10.60             35.38/L              -0.47             111.13             2.56             134.79            -16.34             80.78             11.70             17.98              -0.75      \n                                                                      WEEK 5 DAY 36    901       24.05/L           -13.78            35.90/L               0.05             108.01             -0.56            137.95            -13.17             68.35             -0.73             8.48/L             -10.25     \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nBaseline is the patient's last observation prior to initiation of study drug. Abnormalities are flagged as high (H) or low (L) if\n  outside the Roche standard reference range.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/concomitant-medications/cml01.html",
+    "href": "listings/concomitant-medications/cml01.html",
+    "title": "CML01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nout &lt;- adcm %&gt;%\n  filter(!is.na(CMDECOD)) %&gt;%\n  mutate(\n    ID = paste(SITEID, SUBJID, sep = \"/\"),\n    AGSXRC = paste(AGE, SEX, RACE, sep = \"/\"),\n    TRTSD = toupper(format(as.Date(TRTSDTM), \"%d%b%Y\")),\n    CMASTD = toupper(format(as.Date(ASTDTM), \"%d%b%Y\")),\n    CMSTRFL = ifelse(ASTDY &lt; 0, \"Yes\", \"No\"),\n    CMENRFL = ifelse(CMENRTPT == \"ONGOING\", \"Yes\", \"No\")\n  ) %&gt;%\n  select(\n    ID, AGSXRC, TRT01A, CMDECOD, TRTSD, CMASTD, ASTDY, ADURN,\n    CMSTRFL, CMENRFL, CMDOSE, CMDOSU, CMDOSFRQ, CMROUTE\n  )\n\nvar_labels(out) &lt;- c(\n  ID = \"Center/Patient ID\",\n  AGSXRC = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  CMDECOD = \"Medication Name\",\n  TRTSD = \"Date of First\\nStudy Drug\\nAdministration\",\n  CMASTD = \"Medication\\nStart Date\",\n  ASTDY = \"Study Day\",\n  ADURN = \"Duration\\n(days)\",\n  CMSTRFL = \"Previous?\",\n  CMENRFL = \"Ongoing\\nat Final\\nContact?\",\n  CMDOSE = \"Dose\",\n  CMDOSU = \"Dose Unit\",\n  CMDOSFRQ = \"Frequency\",\n  CMROUTE = \"Route\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ID\", \"AGSXRC\", \"TRT01A\", \"CMDECOD\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Previous and Concomitant Medications\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Previous and Concomitant Medications\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                        Date of First                                                    Ongoing                                                        \n                                                                                          Study Drug     Medication               Duration               at Final                                                       \nCenter/Patient ID            Age/Sex/Race              Treatment      Medication Name   Administration   Start Date   Study Day    (days)    Previous?   Contact?   Dose   Dose Unit       Frequency           Route    \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                47/M/WHITE               A: Drug X       medname A_2/3      04NOV2020      21SEP2021       321        -148        No          No       30    mg/breath          Q4H          INTRAMUSCULAR\n                                                                                          04NOV2020      02DEC2021       393        -42         No          No       41     umol/L           TWICE            UNKNOWN   \n                                                                       medname B_1/4      04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS \n                                                                                          04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS \n                                                                                          04NOV2020      15APR2021       162        -172        No          No       25    ug/kg/day          Q4H           INTRAVENOUS \n                                                                       medname C_1/2      04NOV2020      19MAY2021       196        -165        No          No       22      ug/mL            TID             INHALED   \n                                                                                          04NOV2020      19MAY2021       196        -165        No          No       22      ug/mL            TID             INHALED   \n  BRA-1/id-141                35/F/WHITE             C: Combination    medname A_1/3      25JUL2020      03AUG2022       739        -35         No          No       84      ug/mL            QN              INHALED   \n                                                                                          25JUL2020      10JAN2023       899        -138        No          No       1       DROP      4 TIMES PER MONTH       ORAL     \n                                                                                          25JUL2020      03MAR2023       951        -65         No          No       70       uL              QN               NASAL    \n                                                                       medname A_3/3      25JUL2020      16AUG2021       387        -10         No          No       54     umol/L            QN           INTRAMUSCULAR\n                                                                                          25JUL2020      16AUG2021       387        -10         No          No       54     umol/L            QN           INTRAMUSCULAR\n                                                                       medname B_4/4      25JUL2020      23JUL2023      1093         -2         No          No       55       uL              Q4H           INTRAVENOUS \n                                                                       medname C_2/2      25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   \n                                                                                          25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   \n                                                                                          25JUL2020      23OCT2021       455        -627        No          No       86       mg              Q4W             INHALED   \n  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo      medname A_2/3      15JAN2021      13OCT2021       271        -774        No          No       9      umol/L     4 TIMES PER MONTH      UNKNOWN   \n                                                                       medname A_3/3      15JAN2021      17FEB2021       33         -613        No          No       30      DROP             Q4H             UNKNOWN   \n                                                                                          15JAN2021      02DEC2023      1051         -6         No          No       74    mg/breath         TWICE            INHALED   \n                                                                                          15JAN2021      17FEB2021       33         -613        No          No       30      DROP             Q4H             UNKNOWN   \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/pharmacokinetic/pkpl04.html",
+    "href": "listings/pharmacokinetic/pkpl04.html",
+    "title": "PKPL04",
+    "section": "",
+    "text": "Data Setup\nStandard Listing - CYCLE 1 DAY 1\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(rlistings)\nlibrary(scda)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\nvisit &lt;- \"CYCLE 1 DAY 1\"\ndrug_a &lt;- \"Plasma Drug X\" # numerator drug\ndrug_b &lt;- \"Plasma Drug Y\" # denominator drug\n\nadpp_x &lt;- adpp %&gt;%\n  filter(\n    AVISIT == visit,\n    PPCAT %in% c(drug_a, drug_b),\n    PARAMCD %in% c(\"CMAX\", \"AUCIFO\")\n  ) %&gt;%\n  mutate(\n    PARAM_U = paste0(PARAM, \" (\", AVALU, \")\")\n  )\n\nadpp_ratio &lt;- adpp_x %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(USUBJID, PARAM_U),\n    names_from = PPCAT,\n    values_from = AVAL\n  )\n\nadpp_ratio[, paste0(drug_a, \"/\", drug_b)] &lt;- as.numeric(unlist(adpp_ratio[, drug_a] / adpp_ratio[, drug_b]))\n\nout &lt;- adpp_ratio %&gt;%\n  tidyr::pivot_wider(\n    id_cols = USUBJID,\n    names_from = PARAM_U,\n    names_glue = \"{PARAM_U}\\n{.value}\",\n    values_from = c(all_of(drug_a), all_of(drug_b), paste0(drug_a, \"/\", drug_b))\n  ) %&gt;%\n  select(names(.)[c(1:2, 4, 6, 3, 5, 7)])\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;% var_relabel(USUBJID = \"Subject ID\")\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = \"USUBJID\",\n  disp_cols = names(out),\n  main_title = paste0(\n    \"Listing of Individual \", drug_a, \" \", paste(unique(adpp_x$PARAM), collapse = \" and \"), \" Ratios following \",\n    unique(adpp_x$REGIMEN), \" \", paste(drug_a, drug_b, sep = \" or \"), \", PK Population\\nProtocol: xxnnnnn\",\n    \"\\nVisit: \", unique(adpp_x$AVISIT)\n  ),\n  subtitles = paste0(\"\\nAnalytes: \", paste(drug_a, drug_b, sep = \" and \"))\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Individual Plasma Drug X AUC Infinity Obs and Max Conc Ratios following BID Plasma Drug X or Plasma Drug Y, PK Population\nProtocol: xxnnnnn\nVisit: CYCLE 1 DAY 1\n\nAnalytes: Plasma Drug X and Plasma Drug Y\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                        AUC Infinity Obs (day*ug/mL)   AUC Infinity Obs (day*ug/mL)   AUC Infinity Obs (day*ug/mL)   Max Conc (ug/mL)   Max Conc (ug/mL)        Max Conc (ug/mL)      \n     Subject ID                Plasma Drug X                  Plasma Drug Y           Plasma Drug X/Plasma Drug Y     Plasma Drug X      Plasma Drug Y     Plasma Drug X/Plasma Drug Y\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAB12345-BRA-1-id-105          246.349321001289                      NA                             NA                31.2264481880236          NA                      NA             \nAB12345-BRA-1-id-134          248.519038520728                      NA                             NA                21.7795763901966          NA                      NA             \nAB12345-BRA-1-id-141          204.038850147211               191.797779791421               1.06382279486812         29.5409649407056   38.8911230490524        0.759581174949522     \nAB12345-BRA-1-id-265          196.360864588266               218.652833415662              0.898048570973609         35.6328283094637   34.2215467219396        1.04123956170044      \n AB12345-BRA-1-id-42          210.528307366678                      NA                             NA                26.7845825535397          NA                      NA             \n AB12345-BRA-1-id-93          160.406798051843                      NA                             NA                17.5296885232566          NA                      NA             \nAB12345-BRA-11-id-171         217.543269983548               180.798322952882               1.20323721166508         30.3782220474834   31.615072576154         0.960877820992148     \nAB12345-BRA-11-id-217         272.094354596647                      NA                             NA                34.2812274648873          NA                      NA             \nAB12345-BRA-11-id-237         148.094218281784               193.694022424355              0.764578154907287         32.9103242471385   38.7385450224575        0.849549827647366     \nAB12345-BRA-11-id-321         206.178847103577               216.464946980475               0.95248145244585         33.0064256549217   28.4783979285037         1.1589986816599      \nAB12345-BRA-11-id-345         228.51025073098                       NA                             NA                39.7523164840323          NA                      NA             \nAB12345-BRA-11-id-397         201.536920713046                      NA                             NA                36.5841424116449          NA                      NA             \nAB12345-BRA-11-id-50          189.012389008811                      NA                             NA                21.1977400008473          NA                      NA             \n AB12345-BRA-11-id-9          235.477941027941               207.851453783084               1.13291457308587         27.1559637630099   28.2923295654501        0.959834844995305     \nAB12345-BRA-13-id-177         185.956676853099                      NA                             NA                31.0405525087113          NA                      NA             \nAB12345-BRA-14-id-120         209.878908685802               301.584778421544              0.695920098435608         31.8076450080362   22.9229189133965        1.38759139393227      \nAB12345-BRA-14-id-23          270.799396057463                      NA                             NA                29.2804222629517          NA                      NA             \nAB12345-BRA-15-id-36          183.877364155027                      NA                             NA                37.9405096212457          NA                      NA             \nAB12345-BRA-2-id-296          216.092875093089                      NA                             NA                27.3509307000219          NA                      NA             \nAB12345-BRA-4-id-368          203.23438144437                149.30280248041                1.36122281744199         38.3952821076341   30.8121148640987        1.24610992387189      \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/pharmacokinetic/pkpl01.html",
+    "href": "listings/pharmacokinetic/pkpl01.html",
+    "title": "PKPL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(rlistings)\nlibrary(scda)\n\ndrug_a &lt;- \"Plasma Drug X\"\nspec &lt;- \"Plasma\"\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp_x &lt;- adpp %&gt;% filter(\n  PPCAT == drug_a,\n  PPSPEC == spec\n)\n\nout &lt;- adpp_x %&gt;%\n  mutate(PARAM = paste0(PARAM, \" (\", AVALU, \")\")) %&gt;%\n  select(TRT01A, USUBJID, AVISIT, PARAM, AVAL) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(TRT01A, USUBJID, AVISIT),\n    names_from = PARAM,\n    values_from = AVAL\n  )\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;% var_relabel(\n  TRT01A = \"Treatment Group\",\n  USUBJID = \"Subject ID\",\n  AVISIT = \"Visit\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"TRT01A\", \"USUBJID\", \"AVISIT\"),\n  disp_cols = names(out),\n  main_title = paste(\"Listing of\", drug_a, spec, \"PK Parameters, PK Population\\nProtocol: xxnnnnn\"),\n  subtitles = paste(\"Analyte:\", drug_a)\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Plasma Drug X Plasma PK Parameters, PK Population\nProtocol: xxnnnnn\nAnalyte: Plasma Drug X\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Group        Subject ID             Visit       AUC Infinity Obs (day*ug/mL)   Max Conc (ug/mL)   Total CL Obs (ml/day/kg)\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   A: Drug X      AB12345-BRA-1-id-105      SCREENING           145.191684898102         35.5067335878638       5.1567601025515     \n                                          CYCLE 1 DAY 1         246.349321001289         31.2264481880236       4.41386730113941    \n                                          CYCLE 1 DAY 2         225.443483077171         43.4987268488453       4.81490455551286    \n                  AB12345-BRA-1-id-134      SCREENING           157.461703380688         32.1171292884992       6.0374125711965     \n                                          CYCLE 1 DAY 1         248.519038520728         21.7795763901966        4.561839813278     \n                                          CYCLE 1 DAY 2         230.794839837734         21.0627132276049       6.95200595313275    \n                   AB12345-BRA-1-id-42      SCREENING           194.224015921831         20.4565798423567       6.33709739029277    \n                                          CYCLE 1 DAY 1         210.528307366678         26.7845825535397       3.50776680376268    \n                                          CYCLE 1 DAY 2         167.592869235882         34.8276545020143       4.11969088323673    \n                   AB12345-BRA-1-id-93      SCREENING           186.75868084484          27.3983170052516       3.40495133575408    \n                                          CYCLE 1 DAY 1         160.406798051843         17.5296885232566       3.8508725098954     \n                                          CYCLE 1 DAY 2         252.04512291352          32.4903879259459       6.21586252565961    \n                  AB12345-BRA-11-id-217     SCREENING           215.367414313054         20.8879942219526       6.55883385955605    \n                                          CYCLE 1 DAY 1         272.094354596647         34.2812274648873       5.04441608634882    \n                                          CYCLE 1 DAY 2         174.183265394136          23.04243406023        4.07416508597243    \n                  AB12345-BRA-11-id-345     SCREENING           235.746948097021         26.5740342881269       5.52059967823211    \n                                          CYCLE 1 DAY 1         228.51025073098          39.7523164840323       6.32996327499752    \n                                          CYCLE 1 DAY 2         120.712762389698          24.37143486359        5.02620823564574    \n                  AB12345-BRA-11-id-397     SCREENING           165.925716319045         21.8770819414152       6.3713157196375     \n                                          CYCLE 1 DAY 1         201.536920713046         36.5841424116449       4.32440907316618    \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/pharmacokinetic/pkcl02.html",
+    "href": "listings/pharmacokinetic/pkcl02.html",
+    "title": "PKCL02",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(rlistings)\nlibrary(scda)\n\ndrug_a &lt;- \"Drug X\"\nspec &lt;- \"URINE\"\n\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\")\nadpc_x &lt;- adpc %&gt;%\n  mutate(REGIMEN = ifelse(\"REGIMEN\" %in% names(adpc), REGIMEN, \"BID\")) %&gt;%\n  filter(\n    grepl(drug_a, PARAM),\n    ASMED == spec\n  )\n\nout &lt;- adpc_x %&gt;%\n  tidyr::pivot_longer(\n    cols = c(AVAL, PCVOL),\n    names_to = \"URCD\",\n    values_to = \"VALUE\"\n  ) %&gt;%\n  mutate(\n    URCD = case_when(\n      URCD == \"AVAL\" ~ \"UR_Conc\",\n      URCD == \"PCVOL\" ~ \"Vurine\",\n      TRUE ~ URCD\n    ),\n    UNIT = case_when(\n      URCD == \"UR_Conc\" ~ as.character(AVALU),\n      URCD == \"Vurine\" ~ as.character(PCVOLU),\n      TRUE ~ \"NA\"\n    )\n  ) %&gt;%\n  mutate(\n    PARAM_INT = paste0(\n      URCD, \" (\", UNIT, \") -\\nUrine Collection\\nInterval\",\n      ifelse(PCTPT == \"Predose\", \"\", \" (hours)\"), \":\\n\",\n      gsub(\"[PTH]\", \"\", PCTPT)\n    )\n  ) %&gt;%\n  select(TRT01A, USUBJID, VISIT, PARAM_INT, VALUE) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(TRT01A, USUBJID, VISIT),\n    names_from = PARAM_INT,\n    values_from = VALUE\n  )\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;% var_relabel(\n  TRT01A = \"Treatment Group\",\n  USUBJID = \"Subject ID\",\n  VISIT = \"Visit\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"TRT01A\", \"USUBJID\", \"VISIT\"),\n  disp_cols = names(out),\n  main_title = paste0(\n    \"Listing of \", drug_a, \" Urine Concentration and Volumes following \", unique(adpc_x$REGIMEN)[1],\n    \" of \", drug_a, \", PK Population\\nProtocol: xxnnnnn\"\n  ),\n  subtitles = paste(\"Analyte:\", drug_a)\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Drug X Urine Concentration and Volumes following BID of Drug X, PK Population\nProtocol: xxnnnnn\nAnalyte: Drug X\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                  UR_Conc (ug/mL) -    Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -     UR_Conc (ug/mL) -     Vurine (mL) -  \n                                                  Urine Collection    Urine Collection   Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection    Urine Collection \n                                                      Interval:          Interval:       Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):   Interval (hours):\nTreatment Group        Subject ID         Visit        redose              redose              0 - 4               0 - 4               4 - 8               4 - 8              8 - 12              8 - 12              0 - 24              0 - 24      \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   A: Drug X      AB12345-BRA-1-id-105    Day 1           0                713.94              5.461               96.92               0.562              235.38               0.049              384.98                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                735.22      \n                  AB12345-BRA-1-id-134    Day 1           0               1068.83              4.064               145.1               0.178              352.39               0.006              576.35                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                1080.14     \n                   AB12345-BRA-1-id-42    Day 1           0                817.09              4.277              110.93               0.305              269.39               0.018               440.6                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                737.25      \n                   AB12345-BRA-1-id-93    Day 1           0                864.61              4.324              117.38               0.278              285.06               0.015              466.23                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                757.23      \n                  AB12345-BRA-11-id-217   Day 1           0                724.93              6.225               98.41               0.672              239.01               0.059              390.91                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                1185.46     \n                  AB12345-BRA-11-id-345   Day 1           0                840.09              6.511              114.05               0.588              276.98               0.04               453.01                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                883.89      \n                  AB12345-BRA-11-id-397   Day 1           0                974.41              5.478              132.28               0.354              321.26               0.017              525.44                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                918.67      \n                  AB12345-BRA-11-id-50    Day 1           0                922.97              4.122               125.3               0.228               304.3               0.01                497.7                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                808.08      \n                  AB12345-BRA-13-id-177   Day 1           0                694.09              4.267               94.23               0.421              228.84               0.038              374.28                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                908.45      \n                  AB12345-BRA-14-id-23    Day 1           0                722.84              4.254               98.13               0.386              238.32               0.032              389.78                NA                  NA        \n                                          Day 2          NA                  NA                 NA                  NA                  NA                  NA                  NA                  NA                   0                 862.1      \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/medical-history/mhl01.html",
+    "href": "listings/medical-history/mhl01.html",
+    "title": "MHL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadmh &lt;- synthetic_cdisc_dataset(\"latest\", \"admh\")\n\nout &lt;- admh %&gt;%\n  mutate(\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    ID = paste(SITEID, SUBJID, sep = \"/\"),\n    TRTSDTM = toupper(format(as.Date(TRTSDTM), \"%d%b%Y\")),\n    ASTDTM = toupper(format(as.Date(ASTDTM), \"%d%b%Y\")),\n    AENDTM = toupper(format(as.Date(AENDTM), \"%d%b%Y\"))\n  ) %&gt;%\n  select(ID, ASR, TRT01A, MHBODSYS, MHDECOD, TRTSDTM, ASTDTM, ASTDY, AENDTM, AENDY, ATIREL)\n\nvar_labels(out) &lt;- c(\n  ID = \"Center/Patient ID\",\n  ASR = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  MHBODSYS = \"SOC\",\n  MHDECOD = \"Disease Term\",\n  TRTSDTM = \"Date of First\\nStudy Drug\\nAdministration\",\n  ASTDTM = \"Start Date\\nof Disease\",\n  ASTDY = \"Start Day\\nof Disease\",\n  AENDTM = \"End Date\\nof Disease\",\n  AENDY = \"End Day\\nof Disease\",\n  ATIREL = \"Time Relation\\nof Disease\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"ID\", \"ASR\", \"TRT01A\", \"MHBODSYS\", \"MHDECOD\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Medical History and Concurrent Diseases\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Medical History and Concurrent Diseases\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                            Date of First                                                                         \n                                                                                              Study Drug     Start Date   Start Day     End Date     End Day       Time Relation  \nCenter/Patient ID            Age/Sex/Race              Treatment      SOC    Disease Term   Administration   of Disease   of Disease   of Disease   of Disease      of Disease    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                47/M/WHITE               A: Drug X      cl A    trm A_2/2       04NOV2020      21SEP2021       321       16FEB2022       469       PRIOR_CONCOMITANT\n                                                                                              04NOV2020      02DEC2021       393       13JAN2022       435       PRIOR_CONCOMITANT\n                                                                      cl B    trm B_2/3       04NOV2020      15APR2021       162       04OCT2021       334       PRIOR_CONCOMITANT\n                                                                      cl D    trm D_2/3       04NOV2020      19MAY2021       196       31OCT2021       361       PRIOR_CONCOMITANT\n  BRA-1/id-141                35/F/WHITE             C: Combination   cl A    trm A_1/2       25JUL2020      03AUG2022       739       07SEP2022       774       PRIOR_CONCOMITANT\n                                                                                              25JUL2020      03MAR2023       951       07MAY2023       1016      PRIOR_CONCOMITANT\n                                                                              trm A_2/2       25JUL2020      10JAN2023       899       28MAY2023       1037      PRIOR_CONCOMITANT\n                                                                      cl B    trm B_2/3       25JUL2020      16AUG2021       387       26AUG2021       397       PRIOR_CONCOMITANT\n                                                                      cl D    trm D_1/3       25JUL2020      23JUL2023       1093      25JUL2023       1095      PRIOR_CONCOMITANT\n                                                                              trm D_3/3       25JUL2020      23OCT2021       455       12JUL2023       1082      PRIOR_CONCOMITANT\n  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     cl B    trm B_1/3       15JAN2021      17FEB2021        33       23OCT2022       646       PRIOR_CONCOMITANT\n                                                                                              15JAN2021      13OCT2021       271       26NOV2023       1045      PRIOR_CONCOMITANT\n                                                                                              15JAN2021      02DEC2023       1051      08DEC2023       1057      PRIOR_CONCOMITANT\n  BRA-1/id-265                25/M/WHITE             C: Combination   cl C    trm C_1/2       07OCT2019      11SEP2021       705       15NOV2021       770       PRIOR_CONCOMITANT\n                                                                              trm C_2/2       07OCT2019      30DEC2019        84       16MAR2020       161       PRIOR_CONCOMITANT\n                                                                      cl D    trm D_1/3       07OCT2019      22AUG2021       685       27SEP2021       721       PRIOR_CONCOMITANT\n                                                                              trm D_2/3       07OCT2019      20SEP2020       349       01JUL2021       633       PRIOR_CONCOMITANT\n   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      cl A    trm A_2/2       01JAN2020      09JUN2020       160       22FEB2021       418       PRIOR_CONCOMITANT\n                                                                                              01JAN2020      04APR2021       459       15OCT2021       653       PRIOR_CONCOMITANT\n                                                                                              01JAN2020      20APR2021       475       10AUG2021       587       PRIOR_CONCOMITANT\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael01_nollt.html",
+    "href": "listings/adverse-events/ael01_nollt.html",
+    "title": "AEL01_NOLLT",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nout &lt;- adae %&gt;%\n  select(AESOC, AEDECOD, AETERM) %&gt;%\n  unique()\n\nvar_labels(out) &lt;- c(\n  AESOC = \"MedDRA System Organ Class\",\n  AEDECOD = \"MedDRA Preferred Term\",\n  AETERM = \"Investigator-Specified\\nAdverse Event Term\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"AESOC\", \"AEDECOD\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Preferred Terms and Investigator-Specified Adverse Event Terms\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Preferred Terms and Investigator-Specified Adverse Event Terms\n\n——————————————————————————————————————————————————————————————————————————\n                                                    Investigator-Specified\nMedDRA System Organ Class   MedDRA Preferred Term     Adverse Event Term  \n——————————————————————————————————————————————————————————————————————————\n          cl A                  dcd A.1.1.1.1           trm A.1.1.1.1     \n                                dcd A.1.1.1.2           trm A.1.1.1.2     \n          cl B                  dcd B.1.1.1.1           trm B.1.1.1.1     \n                                dcd B.2.1.2.1           trm B.2.1.2.1     \n                                dcd B.2.2.3.1           trm B.2.2.3.1     \n          cl C                  dcd C.1.1.1.3           trm C.1.1.1.3     \n                                dcd C.2.1.2.1           trm C.2.1.2.1     \n          cl D                  dcd D.1.1.1.1           trm D.1.1.1.1     \n                                dcd D.1.1.4.2           trm D.1.1.4.2     \n                                dcd D.2.1.5.3           trm D.2.1.5.3     \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael02_ed.html",
+    "href": "listings/adverse-events/ael02_ed.html",
+    "title": "AEL02_ED",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\nlibrary(lubridate)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadae_anl &lt;- adae %&gt;%\n  filter(SAFFL == \"Y\") %&gt;%\n  mutate(\n    DHM = as.period(LDOSEDTM %--% ASTDTM),\n    TMOM = minute(DHM) + ifelse(second(DHM) &gt;= 30, 1, 0),\n    TMOH = hour(DHM) + ifelse(TMOM == 60, 1, 0),\n    TMOD = day(DHM) + ifelse(TMOH == 24, 1, 0)\n  ) %&gt;%\n  mutate(\n    TMOM = TMOM %% 60,\n    TMOH = TMOH %% 24\n  )\n\nout &lt;- adae_anl %&gt;%\n  mutate(\n    ADURN = AENDY - ASTDY + 1,\n    cent_subj = paste(SITEID, SUBJID, sep = \"/\"),\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    AESER_F = if_else(AESER == \"Y\", \"Yes\", \"No\", \"\"),\n    AEREL_F = if_else(AEREL == \"Y\", \"Yes\", \"No\", \"\"),\n    AECONTRT_F = if_else(AECONTRT == \"Y\", \"Yes\", \"No\", \"\"),\n    AEOUT_F = case_when(\n      AEOUT == \"FATAL\" ~ 1,\n      AEOUT == \"NOT RECOVERED/NOT RESOLVED\" ~ 2,\n      AEOUT == \"RECOVERED/RESOLVED\" ~ 3,\n      AEOUT == \"RECOVERED/RESOLVED WITH SEQUELAE\" ~ 4,\n      AEOUT == \"RECOVERING/RESOLVING\" ~ 5,\n      AEOUT == \"UNKNOWN\" ~ 6\n    ),\n    AEACN_F = case_when(\n      AEACN == \"DOSE INCREASED\" ~ 1,\n      AEACN == \"DOSE NOT CHANGED\" ~ 2,\n      AEACN == \"DOSE REDUCED\" | AEACN == \"DOSE RATE REDUCED\" ~ 3,\n      AEACN == \"DRUG INTERRUPTED\" ~ 4,\n      AEACN == \"DRUG WITHDRAWN\" ~ 5,\n      AEACN == \"NOT APPLICABLE\" | AEACN == \"NOT EVALUABLE\" ~ 6,\n      AEACN == \"UNKNOWN\" ~ 7\n    )\n  ) %&gt;%\n  select(\n    cent_subj, ASR, TRT01A, AEDECOD, ASTDY, TMOD, TMOH, TMOM,\n    ADURN, AESER_F, AESEV, AEREL_F, AEOUT_F, AECONTRT_F, AEACN_F\n  )\n\nout &lt;- out %&gt;% var_relabel(\n  cent_subj  = \"Center/Patient ID\",\n  ASR        = \"Age/Sex/Race\",\n  TRT01A     = \"Treatment\",\n  AEDECOD    = \"Adverse\\nEvent MedDRA\\nPreferred Term\",\n  ASTDY      = \"Study\\nDay of\\nOnset\",\n  TMOD       = \"Time from\\nLast Dose\\nto Onset\\ndays\",\n  TMOH       = \"Time from\\nLast Dose\\nto Onset\\nhrs\",\n  TMOM       = \"Time from\\nLast Dose\\nto Onset\\nmins\",\n  ADURN      = \"AE\\nDuration\\nin Days\",\n  AESER_F    = \"Serious\",\n  AESEV      = \"Most\\nExtreme\\nIntensity\",\n  AEREL_F    = \"Caused by\\nStudy\\nDrug\",\n  AEOUT_F    = \"Outcome\\n(1)\",\n  AECONTRT_F = \"Treatment\\nfor AE\",\n  AEACN_F    = \"Action\\nTaken\\n(2)\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"cent_subj\", \"ASR\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Adverse Events (for early development studies)\",\n  main_footer = \"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =\n    recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\"\n)\n\nhead(lsting, 20)\n\nListing of Adverse Events (for early development studies)\n\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                Time from   Time from   Time from                                                                            \n                                                                         Adverse       Study    Last Dose   Last Dose   Last Dose      AE                  Most      Caused by                         Action\n                                                                       Event MedDRA    Day of   to Onset    to Onset    to Onset    Duration              Extreme      Study     Outcome   Treatment   Taken \nCenter/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Onset      days         hrs        mins      in Days    Serious   Intensity     Drug        (1)      for AE      (2)  \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd B.2.1.2.1     162         7          19           4         173        No      MODERATE       No          5         Yes        2   \n                                                                      dcd D.1.1.4.2     196         1          20          48         166        No      MODERATE       No          5         No         2   \n                                                                      dcd A.1.1.1.2     321        28          12          54         149        Yes     MODERATE       No          5         Yes        2   \n                                                                      dcd A.1.1.1.2     393        12          19          17          43        Yes     MODERATE       No          5         No         5   \n  BRA-1/id-141                35/F/WHITE             C: Combination   dcd B.2.1.2.1     387        25           8          22          11        No      MODERATE       No          3         Yes        1   \n                                                                      dcd D.2.1.5.3     455         6          16          56         628        No        MILD         Yes         3         No         1   \n                                                                      dcd A.1.1.1.1     739         0           9          38          36        No        MILD         No          4         Yes        3   \n                                                                      dcd A.1.1.1.2     899        -1          23           6         139        Yes     MODERATE       No          4         Yes        2   \n                                                                      dcd A.1.1.1.1     951         6          22          41          66        No        MILD         No          5         No         1   \n                                                                      dcd D.1.1.1.1     1093       21           5          35          3         Yes      SEVERE        Yes         1         No         6   \n  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      33        11          10          13         614        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd B.1.1.1.1     271        14           7          24         775        Yes      SEVERE        Yes         1         Yes        6   \n                                                                      dcd B.1.1.1.1     1051       26          16          28          7         Yes      SEVERE        Yes         1         Yes        6   \n  BRA-1/id-265                25/M/WHITE             C: Combination   dcd C.2.1.2.1      84        28          16          25          78        No      MODERATE       Yes         2         Yes        5   \n                                                                      dcd D.1.1.4.2     349         1           6          20         285        No      MODERATE       No          3         Yes        7   \n                                                                      dcd D.1.1.1.1     685        15           8          59          37        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd C.1.1.1.3     705        22           4          54          66        No       SEVERE        Yes         4         Yes        7   \n   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd C.2.1.2.1      39        30           9           4         506        No      MODERATE       Yes         2         No         6   \n                                                                      dcd D.1.1.1.1      64        26          17          10         630        Yes      SEVERE        Yes         1         No         6   \n                                                                      dcd C.2.1.2.1      95         4          12          58         306        No      MODERATE       Yes         5         No         2   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae; 5 =\n    recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] lubridate_1.9.2  rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2\n[5] scda_0.1.6       dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] timechange_0.2.0  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1          tidyselect_1.2.0 \n[29] utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0  \n[33] withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/adverse-events/ael03.html",
+    "href": "listings/adverse-events/ael03.html",
+    "title": "AEL03",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nout &lt;- adae %&gt;%\n  filter(AESER == \"Y\") %&gt;%\n  mutate(\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    Date_First = toupper(format(as.Date(TRTSDTM), \"%d%b%Y\")),\n    Duration = AENDY - ASTDY + 1,\n    Related = ifelse(AEREL == \"Y\", \"Yes\", ifelse(AEREL == \"N\", \"No\", \"\")),\n    Outcome = case_when(\n      AEOUT == \"FATAL\" ~ 1,\n      AEOUT == \"NOT RECOVERED/NOT RESOLVED\" ~ 2,\n      AEOUT == \"RECOVERED/RESOLVED\" ~ 3,\n      AEOUT == \"RECOVERED/RESOLVED WITH SEQUELAE\" ~ 4,\n      AEOUT == \"RECOVERING/RESOLVING\" ~ 5,\n      AEOUT == \"UNKNOWN\" ~ 6\n    ),\n    Treated = ifelse(AECONTRT == \"Y\", \"Yes\", ifelse(AECONTRT == \"N\", \"No\", \"\")),\n    Action = case_when(\n      AEACN == \"DOSE INCREASED\" ~ 1,\n      AEACN == \"DOSE NOT CHANGED\" ~ 2,\n      AEACN == \"DOSE REDUCED\" | AEACN == \"DOSE RATE REDUCED\" ~ 3,\n      AEACN == \"DRUG INTERRUPTED\" ~ 4,\n      AEACN == \"DRUG WITHDRAWN\" ~ 5,\n      AEACN == \"NOT APPLICABLE\" | AEACN == \"NOT EVALUABLE\" ~ 6,\n      AEACN == \"UNKNOWN\" ~ 7\n    ),\n    SERREAS = case_when(\n      AESDTH == \"Y\" ~ \"1\",\n      AESLIFE == \"Y\" ~ \"2\",\n      AESHOSP == \"Y\" ~ \"3\",\n      AESDISAB == \"Y\" ~ \"4\",\n      AESCONG == \"Y\" ~ \"5\",\n      AESMIE == \"Y\" ~ \"6\",\n      TRUE ~ \" \"\n    )\n  ) %&gt;%\n  select(CPID, ASR, TRT01A, AEDECOD, Date_First, ASTDY, Duration, AESEV, Related, Outcome, Treated, Action, SERREAS)\n\nvar_labels(out) &lt;- c(\n  CPID = \"Center/Patient ID\",\n  ASR = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  AEDECOD = \"Adverse\\nEvent MedDRA\\nPreferred Term\",\n  Date_First = \"Date of\\nFirst Study\\nDrug\\nAdministration\",\n  ASTDY = \"Study\\nDay of\\nOnset\",\n  Duration = \"AE\\nDuration\\nin Days\",\n  AESEV = \"Most\\nExtreme\\nIntensity\",\n  Related = \"Caused by\\nStudy\\nDrug\",\n  Outcome = \"Outcome\\n(1)\",\n  Treated = \"Treatment\\nfor AE\",\n  Action = \"Action\\nTaken\\n(2)\",\n  SERREAS = \"Reason\\nClassified\\nas Serious\\n(3)\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CPID\", \"ASR\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Serious Adverse Events\",\n  main_footer = \"(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae;\n    5 = recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n(3) Reason classified as serious: 1 = resulted in death; 2 = life threatening; 3 = required prolonged in patient\n    hospitalization; 4 = disabling; 5 = a congenital anomaly/birth defect in offspring of study subject; 6 = does not meet any of\n    the above serious criteria, but may jeopardize the subject, and may require medical or surgical intervention to prevent one of\n    the outcomes listed above.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\"\n)\n\nhead(lsting, 20)\n\nListing of Serious Adverse Events\n\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                          Date of                                                                                    Reason  \n                                                                         Adverse        First Study     Study       AE        Most      Caused by                         Action   Classified\n                                                                       Event MedDRA         Drug        Day of   Duration    Extreme      Study     Outcome   Treatment   Taken    as Serious\nCenter/Patient ID            Age/Sex/Race              Treatment      Preferred Term   Administration   Onset    in Days    Intensity     Drug        (1)      for AE      (2)        (3)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-134                47/M/WHITE               A: Drug X      dcd A.1.1.1.2      04NOV2020       321       149      MODERATE       No          5         Yes        2          4     \n                                                                      dcd A.1.1.1.2      04NOV2020       393        43      MODERATE       No          5         No         5          5     \n  BRA-1/id-141                35/F/WHITE             C: Combination   dcd A.1.1.1.2      25JUL2020       899       139      MODERATE       No          4         Yes        2          4     \n                                                                      dcd D.1.1.1.1      25JUL2020       1093       3        SEVERE        Yes         1         No         6          1     \n  BRA-1/id-236      32/M/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JAN2021        33       614       SEVERE        Yes         1         No         6          1     \n                                                                      dcd B.1.1.1.1      15JAN2021       271       775       SEVERE        Yes         1         Yes        6          1     \n                                                                      dcd B.1.1.1.1      15JAN2021       1051       7        SEVERE        Yes         1         Yes        6          1     \n  BRA-1/id-265                25/M/WHITE             C: Combination   dcd D.1.1.1.1      07OCT2019       685        37       SEVERE        Yes         1         No         6          1     \n   BRA-1/id-42      36/M/BLACK OR AFRICAN AMERICAN     A: Drug X      dcd D.1.1.1.1      01JAN2020        64       630       SEVERE        Yes         1         No         6          1     \n                                                                      dcd A.1.1.1.2      01JAN2020       160       259      MODERATE       No          2         Yes        2          4     \n                                                                      dcd B.2.2.3.1      01JAN2020       292        50        MILD         No          3         No         2          4     \n                                                                      dcd A.1.1.1.2      01JAN2020       459       195      MODERATE       No          5         Yes        2          5     \n                                                                      dcd B.1.1.1.1      01JAN2020       470       131       SEVERE        Yes         1         No         6          1     \n                                                                      dcd A.1.1.1.2      01JAN2020       475       113      MODERATE       No          4         Yes        2          4     \n                                                                      dcd B.1.1.1.1      01JAN2020       641        15       SEVERE        Yes         1         Yes        6          1     \n   BRA-1/id-65      25/F/BLACK OR AFRICAN AMERICAN     B: Placebo     dcd B.1.1.1.1      15JUL2019       349       441       SEVERE        Yes         1         No         6          1     \n   BRA-1/id-93                34/F/ASIAN               A: Drug X      dcd D.1.1.1.1      20JUN2020       316       250       SEVERE        Yes         1         No         6          1     \n                                                                      dcd B.1.1.1.1      20JUN2020       523        24       SEVERE        Yes         1         No         6          1     \n                                                                      dcd B.2.2.3.1      20JUN2020       596        10        MILD         No          3         Yes        2          4     \n  BRA-11/id-321               33/F/ASIAN             C: Combination   dcd A.1.1.1.2      06OCT2020       427       335      MODERATE       No          4         No         6          2     \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\n(1) Outcome: 1 = fatal; 2 = not recovered/not resolved; 3 = recovered/resolved; 4 = recovered/resolved with sequelae;\n    5 = recovering/resolving; 6 = unknown.\n(2) Action taken with study drug: 1 = dose increased; 2 = dose not changed; 3 = dose reduced; 4 = drug interrupted; 5 = drug\n    withdrawn; 6 = not applicable; 7 = unknown.\n(3) Reason classified as serious: 1 = resulted in death; 2 = life threatening; 3 = required prolonged in patient\n    hospitalization; 4 = disabling; 5 = a congenital anomaly/birth defect in offspring of study subject; 6 = does not meet any of\n    the above serious criteria, but may jeopardize the subject, and may require medical or surgical intervention to prevent one of\n    the outcomes listed above.\n*  Study day derived from imputed onset date.\n** Duration derived from imputed onset date and/or end date.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/lab-results/lbl02a.html",
+    "href": "listings/lab-results/lbl02a.html",
+    "title": "LBL02A",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_x &lt;- adlb %&gt;%\n  filter(\n    ANRIND %in% c(\"LOW\", \"HIGH\"),\n    !ATOXGR %in% c(\"0\", \"\"),\n    LBTEST != \"\"\n  ) %&gt;%\n  mutate(\n    LBTEST_U = paste0(LBTEST, \" (\", AVALU, \")\"),\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    ADTM = toupper(format(as.Date(ADTM), \"%d%b%Y\")),\n    AVAL = format(round(AVAL, 1), nsmall = 1),\n    LBNRNG = paste(format(round(ANRLO, 1), nsmall = 1), format(round(ANRHI, 1), nsmall = 1), sep = \" - \"),\n    ANRIND_GR = factor(\n      case_when(\n        ANRIND == \"LOW\" ~ paste0(\"L\", sub(\"-\", \"\", ATOXGR)),\n        ANRIND == \"HIGH\" ~ paste0(\"H\", ATOXGR)\n      )\n    )\n  ) %&gt;%\n  select(LBTEST_U, TRT01A, CPID, ADY, ADTM, AVAL, ADY, LBNRNG, ANRIND_GR) %&gt;%\n  unique() %&gt;%\n  arrange(CPID, ADY) %&gt;%\n  group_by(LBTEST_U, CPID) %&gt;%\n  mutate(DLD = ADY - lag(ADY)) %&gt;%\n  ungroup() %&gt;%\n  mutate(DLD = ifelse(is.na(DLD), 0, DLD))\n\nout &lt;- adlb_x %&gt;%\n  select(LBTEST_U, TRT01A, CPID, ADY, ADTM, DLD, AVAL, LBNRNG, ANRIND_GR)\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    LBTEST_U = \"Lab Test (Unit)\",\n    TRT01A = \"Treatment\",\n    CPID = \"Center/Patient ID\",\n    ADY = \"Study\\nDay\",\n    ADTM = \"Date\",\n    DLD = \"Days Since\\nLast Dose of\\nStudy Drug\",\n    AVAL = \"Result\",\n    LBNRNG = \"Lab Normal\\nRange\",\n    ANRIND_GR = \"NCI\\nCTCAE\\nGrade\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"LBTEST_U\", \"TRT01A\", \"CPID\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 1\",\n  main_footer = \"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Laboratory Abnormalities Defined by NCI CTCAE Grade &gt;= 1\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                                  Days Since                           NCI \n                                                                             Study               Last Dose of            Lab Normal   CTCAE\n             Lab Test (Unit)                 Treatment   Center/Patient ID    Day      Date       Study Drug    Result     Range      Grade\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement (U/L)   A: Drug X     BRA-1/id-105       80     27MAY2020        0          4.3     7.0 - 55.0    L4  \n                                                                              398    10APR2021       318         3.7     7.0 - 55.0    L3  \n                                                            BRA-1/id-93       207    13JAN2021        0          6.1     7.0 - 55.0    L1  \n                                                           BRA-11/id-397      326    19MAY2021        0          1.5     7.0 - 55.0    L1  \n                                                           BRA-14/id-23       594    22JUN2021        0          0.6     7.0 - 55.0    L1  \n                                                           BRA-2/id-296       281    30OCT2021        0          2.6     7.0 - 55.0    L1  \n                                                                              734    26JAN2023       453         3.9     7.0 - 55.0    L1  \n                                                            CAN-1/id-18       465    12APR2022        0          1.8     7.0 - 55.0    L2  \n                                                           CHN-1/id-133       127    13DEC2020        0          5.6     7.0 - 55.0    L2  \n                                                                              197    21FEB2021        70         1.2     7.0 - 55.0    L4  \n                                                           CHN-1/id-199       277    11OCT2020        0          5.3     7.0 - 55.0    L4  \n                                                                              672    10NOV2021       395         6.8     7.0 - 55.0    L2  \n                                                           CHN-1/id-235       348    25JUN2020        0          3.0     7.0 - 55.0    L3  \n                                                                              381    28JUL2020        33         4.7     7.0 - 55.0    L1  \n                                                            CHN-1/id-26       905    07JAN2023        0          1.1     7.0 - 55.0    L1  \n                                                           CHN-1/id-275       364    01JUN2021        0          5.1     7.0 - 55.0    L2  \n                                                           CHN-1/id-277       483    12MAY2022        0          1.1     7.0 - 55.0    L4  \n                                                           CHN-1/id-287       182    23MAY2020        0          5.9     7.0 - 55.0    L2  \n                                                                              191    01JUN2020        9          5.3     7.0 - 55.0    L3  \n                                                                              515    21APR2021       324         2.9     7.0 - 55.0    L4  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nNCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/lab-results/lbl01_rls.html",
+    "href": "listings/lab-results/lbl01_rls.html",
+    "title": "LBL01_RLS",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  filter(!is.na(AVAL))\n\nadlb_x &lt;- adlb %&gt;%\n  mutate(ANRIND = factor(\n    case_when(\n      ANRIND == \"LOW\" & AVAL &gt; stats::quantile(adlb$AVAL, probs = c(0.1)) ~ \"L\",\n      ANRIND == \"HIGH\" & AVAL &lt; stats::quantile(adlb$AVAL, probs = c(0.9)) ~ \"H\",\n      ANRIND == \"LOW\" & AVAL &lt;= stats::quantile(adlb$AVAL, probs = c(0.1)) ~ \"LL\",\n      ANRIND == \"HIGH\" & AVAL &gt;= stats::quantile(adlb$AVAL, probs = c(0.9)) ~ \"HH\",\n      TRUE ~ as.character(ANRIND)\n    ),\n    levels = c(\"\", \"H\", \"HH\", \"L\", \"LL\", \"NORMAL\")\n  ))\n\nadlb_x &lt;- adlb_x %&gt;%\n  filter(!is.na(LBSEQ) & !is.na(ADY) & ANRIND != \"\") %&gt;%\n  mutate(\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    PARAM_U = paste0(PARAMCD, \"\\n(\", AVALU, \")\"),\n    AVALC = as.character(format(round(AVAL, 2), nsmall = 2))\n  ) %&gt;%\n  mutate(AVAL_GR = ifelse(\n    !ANRIND %in% c(\"H\", \"HH\", \"L\", \"LL\"),\n    AVALC,\n    paste(AVALC, ANRIND, sep = \" / \")\n  )) %&gt;%\n  select(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) %&gt;%\n  unique()\n\nout &lt;- adlb_x %&gt;%\n  arrange(CPID, ADY, PARAM_U, LBSEQ) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(TRT01A, CPID, ADY),\n    names_from = PARAM_U,\n    values_from = AVAL_GR\n  ) %&gt;%\n  group_by(CPID) %&gt;%\n  mutate(DLD = ADY - lag(ADY)) %&gt;%\n  ungroup() %&gt;%\n  select(CPID, TRT01A, ADY, DLD, unique(adlb_x$PARAM_U))\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    TRT01A = \"Treatment\",\n    CPID = \"Center/Patient ID\",\n    ADY = \"Study\\nDay\",\n    DLD = \"Days Since\\nLast Dose of\\nStudy Drug\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CPID\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Laboratory Test Results Using Roche Safety Lab Standardization\",\n  main_footer = \"Abnormalities are flagged as high (H) or low (L) if outside the Roche standard reference range; high high (HH) or low low (LL) if\n  outside the Roche marked reference range with a clinically relevant change from baseline. \"\n)\n\nhead(lsting, 20)\n\nListing of Laboratory Test Results Using Roche Safety Lab Standardization\n\n—————————————————————————————————————————————————————————————————————————————————————————\n                                              Days Since                                 \n                                     Study   Last Dose of      ALT         CRP       IGA \nCenter/Patient ID     Treatment       Day     Study Drug      (U/L)      (mg/L)     (g/L)\n—————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-105        A: Drug X       80          NA        4.30 / L      9.09      2.84 \n                                      149         69          24.70       9.15      2.93 \n                                      314        165          24.87     10.89 / H   2.66 \n                                      398         84        3.67 / L      8.14      2.86 \n                                      470         72          18.55     10.59 / H   2.88 \n                                      528         58          7.73      10.09 / H   2.93 \n                                      535         7           23.51       9.20      2.88 \n  BRA-1/id-134        A: Drug X       225         NA          7.37      10.46 / H   2.86 \n                                      227         2           16.42     7.43 / L    2.76 \n                                      255         28          11.16       9.41      2.75 \n                                      269         14          15.89     10.02 / H   2.84 \n                                      357         88          24.35       8.01      2.86 \n                                      436         79          16.03       8.51      2.98 \n                                      440         4           17.21     7.63 / L    2.78 \n  BRA-1/id-141      C: Combination     4          NA          11.32       9.21      2.84 \n                                      52          48          25.77     10.00 / H   2.69 \n                                      189        137          32.73       9.08      2.85 \n                                      262         73          34.69       8.81      2.81 \n                                      386        124          8.58        8.81      2.81 \n                                      425         39          19.58       8.79      2.87 \n—————————————————————————————————————————————————————————————————————————————————————————\n\nAbnormalities are flagged as high (H) or low (L) if outside the Roche standard reference range; high high (HH) or low low (LL) if\n  outside the Roche marked reference range with a clinically relevant change from baseline. \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/lab-results/lbl01.html",
+    "href": "listings/lab-results/lbl01.html",
+    "title": "LBL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_x &lt;- adlb %&gt;%\n  filter(!is.na(AVAL) & !is.na(LBSEQ) & !is.na(ADY) & ANRIND != \"\") %&gt;%\n  mutate(\n    CPID = paste(SITEID, SUBJID, sep = \"/\"),\n    PARAM_U = paste0(PARAMCD, \"\\n(\", AVALU, \" / NCI CTCAE grade)\"),\n    ANRIND = factor(\n      case_when(\n        ANRIND == \"LOW\" ~ \"L\",\n        ANRIND == \"HIGH\" ~ \"H\",\n        TRUE ~ as.character(ANRIND)\n      ),\n      levels = c(\"\", \"H\", \"L\", \"NORMAL\")\n    ),\n    AVALC = as.character(format(round(AVAL, 2), nsmall = 2))\n  ) %&gt;%\n  mutate(AVAL_GR = ifelse(\n    !ANRIND %in% c(\"H\", \"L\"),\n    AVALC,\n    paste(AVALC, paste0(ANRIND, sub(\"-\", \"\", ATOXGR)), sep = \" / \")\n  )) %&gt;%\n  select(CPID, TRT01A, ADY, LBSEQ, PARAM_U, AVAL_GR) %&gt;%\n  unique()\n\nout &lt;- adlb_x %&gt;%\n  arrange(CPID, ADY, PARAM_U, LBSEQ) %&gt;%\n  tidyr::pivot_wider(\n    id_cols = c(TRT01A, CPID, ADY),\n    names_from = PARAM_U,\n    values_from = AVAL_GR\n  ) %&gt;%\n  group_by(CPID) %&gt;%\n  mutate(DLD = ADY - lag(ADY)) %&gt;%\n  ungroup() %&gt;%\n  select(CPID, TRT01A, ADY, DLD, unique(adlb_x$PARAM_U))\n\nvar_labels(out) &lt;- names(out)\nout &lt;- out %&gt;%\n  var_relabel(\n    TRT01A = \"Treatment\",\n    CPID = \"Center/Patient ID\",\n    ADY = \"Study\\nDay\",\n    DLD = \"Days Since\\nLast Dose of\\nStudy Drug\"\n  )\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CPID\", \"TRT01A\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Laboratory Test Results\",\n  main_footer = \"NCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\"\n)\n\nhead(lsting, 20)\n\nListing of Laboratory Test Results\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                              Days Since                                                                                \n                                     Study   Last Dose of             ALT                       CRP                        IGA          \nCenter/Patient ID     Treatment       Day     Study Drug    (U/L / NCI CTCAE grade)   (mg/L / NCI CTCAE grade)   (g/L / NCI CTCAE grade)\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-105        A: Drug X       80          NA               4.30 / L4                    9.09                      2.84          \n                                      149         69                 24.70                      9.15                      2.93          \n                                      314        165                 24.87                   10.89 / H2                   2.66          \n                                      398         84               3.67 / L3                    8.14                      2.86          \n                                      470         72                 18.55                   10.59 / H3                   2.88          \n                                      528         58                 7.73                    10.09 / H3                   2.93          \n                                      535         7                  23.51                      9.20                      2.88          \n  BRA-1/id-134        A: Drug X       225         NA                 7.37                    10.46 / H1                   2.86          \n                                      227         2                  16.42                   7.43 / L1                    2.76          \n                                      255         28                 11.16                      9.41                      2.75          \n                                      269         14                 15.89                   10.02 / H4                   2.84          \n                                      357         88                 24.35                      8.01                      2.86          \n                                      436         79                 16.03                      8.51                      2.98          \n                                      440         4                  17.21                   7.63 / L3                    2.78          \n  BRA-1/id-141      C: Combination     4          NA                 11.32                      9.21                      2.84          \n                                      52          48                 25.77                   10.00 / H2                   2.69          \n                                      189        137                 32.73                      9.08                      2.85          \n                                      262         73                 34.69                      8.81                      2.81          \n                                      386        124                 8.58                       8.81                      2.81          \n                                      425         39                 19.58                      8.79                      2.87          \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nNCI CTCAE grade is displayed as abnormal high (H) or low (L) followed by the grade.\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         purrr_1.0.2       generics_0.1.3    jsonlite_1.8.7   \n [9] glue_1.6.2        backports_1.4.1   htmltools_0.5.6   brio_1.1.3       \n[13] fansi_1.0.4       rmarkdown_2.25    grid_4.3.1        evaluate_0.21    \n[17] fastmap_1.1.1     yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1   \n[21] codetools_0.2-19  htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3  \n[25] tidyr_1.3.0       rstudioapi_0.15.0 digest_0.6.33     R6_2.5.1         \n[29] tidyselect_1.2.0  utf8_1.2.3        pillar_1.9.0      magrittr_2.0.3   \n[33] checkmate_2.2.0   withr_2.5.0       tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/disposition/dsl01.html",
+    "href": "listings/disposition/dsl01.html",
+    "title": "DSL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(rlistings)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\nout &lt;- adsl %&gt;%\n  filter(AEWITHFL == \"Y\") %&gt;%\n  mutate(\n    ID = paste(SITEID, SUBJID, sep = \"/\"),\n    ASR = paste(AGE, SEX, RACE, sep = \"/\"),\n    SSADM = toupper(format(as.Date(TRTSDTM), format = \"%d%b%Y\")),\n    STDWD = as.numeric(ceiling(difftime(TRTEDTM, TRTSDTM, units = \"days\"))),\n    DISCONT = ifelse(!is.na(DCSREAS) & toupper(EOSSTT) == \"DISCONTINUED\", \"Yes\", \"No\")\n  ) %&gt;%\n  select(ID, ASR, TRT01A, SSADM, STDWD, DISCONT)\n\nvar_labels(out) &lt;- c(\n  ID = \"Center/Patient ID\",\n  ASR = \"Age/Sex/Race\",\n  TRT01A = \"Treatment\",\n  SSADM = \"Date of First\\nStudy Drug\\nAdministration\",\n  STDWD = \"Study Day\\nof Withdrawal\",\n  DISCONT = \"Discontinued\\nEarly from Study?\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  disp_cols = names(out),\n  main_title = \"Listing of Patients with Study Drug Withdrawn Due to Adverse Events\"\n)\n\nsorting incoming data by key columns\n\nCodehead(lsting, 20)\n\nListing of Patients with Study Drug Withdrawn Due to Adverse Events\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                                                      Date of First                                     \n                                                                                        Study Drug       Study Day       Discontinued   \nCenter/Patient ID                    Age/Sex/Race                      Treatment      Administration   of Withdrawal   Early from Study?\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n   BRA-1/id-42              36/M/BLACK OR AFRICAN AMERICAN             A: Drug X        01JAN2020           NA                No        \n  BRA-11/id-237                       64/F/ASIAN                     C: Combination     10MAR2020          1096               No        \n   CHN-1/id-26                        29/M/WHITE                       A: Drug X        16JUL2020          1096               No        \n   CHN-1/id-62                        36/F/WHITE                       A: Drug X        22NOV2020           455               Yes       \n  CHN-11/id-256                       23/M/ASIAN                       A: Drug X        17MAR2020          1096               No        \n  CHN-11/id-257                       32/F/ASIAN                     C: Combination     15NOV2020          1096               No        \n  CHN-11/id-263                       34/F/ASIAN                     C: Combination     03APR2019          1096               No        \n  CHN-11/id-349                       40/M/ASIAN                     C: Combination     13NOV2020          1096               No        \n  CHN-11/id-91              44/M/BLACK OR AFRICAN AMERICAN           C: Combination     29MAY2020           625               Yes       \n  CHN-13/id-102                       37/M/ASIAN                       B: Placebo       23MAR2019          1096               No        \n  CHN-15/id-262             35/M/BLACK OR AFRICAN AMERICAN           C: Combination     26FEB2019          1096               No        \n  CHN-17/id-31                        35/F/ASIAN                     C: Combination     17NOV2019           NA                No        \n  CHN-3/id-333              30/F/BLACK OR AFRICAN AMERICAN             B: Placebo       13JAN2020           NA                No        \n   CHN-7/id-28          40/M/AMERICAN INDIAN OR ALASKA NATIVE          B: Placebo       11MAR2019          1096               No        \n   CHN-9/id-11      28/F/NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER     B: Placebo       27JAN2021           388               Yes       \n  CHN-9/id-147                        26/F/ASIAN                       B: Placebo       06FEB2020           NA                No        \n  NGA-11/id-173             24/F/BLACK OR AFRICAN AMERICAN           C: Combination     10MAR2019          1096               No        \n  PAK-2/id-191          38/F/AMERICAN INDIAN OR ALASKA NATIVE        C: Combination     07APR2019          1096               No        \n  RUS-18/id-359             47/F/BLACK OR AFRICAN AMERICAN             A: Drug X        08JUN2019          1096               No        \n  USA-11/id-100                       40/F/ASIAN                     C: Combination     10MAR2020           705               Yes       \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 dplyr_1.1.3     \n[5] scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] pkgconfig_2.0.3   htmlwidgets_1.6.2 testthat_3.1.10   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "listings/exposure/exl01.html",
+    "href": "listings/exposure/exl01.html",
+    "title": "EXL01",
+    "section": "",
+    "text": "Data Setup\nStandard Listing\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(rlistings)\n\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\nout &lt;- adex %&gt;%\n  filter(PARAMCD == \"DOSE\" & !is.na(AVAL) & SAFFL == \"Y\") %&gt;%\n  mutate(\n    CRTNPT = paste(SITEID, SUBJID, sep = \"/\")\n  ) %&gt;%\n  arrange(CRTNPT, AVISIT) %&gt;%\n  select(CRTNPT, AVISIT, EXSTDY, EXENDY, TRT01A, AVAL, AVALU, EXDOSFRQ, EXROUTE)\n\nvar_labels(out) &lt;- c(\n  CRTNPT = \"Center/Subject ID\",\n  AVISIT = \"Visit\",\n  EXSTDY = \"Study Day\\nFrom\",\n  EXENDY = \"Study Day\\nTo\",\n  TRT01A = \"Treatment\",\n  AVAL = \"Dose\",\n  AVALU = \"Unit\",\n  EXDOSFRQ = \"Frequency\",\n  EXROUTE = \"Route\"\n)\n\n\n\n\n\nCodelsting &lt;- as_listing(\n  out,\n  key_cols = c(\"CRTNPT\", \"AVISIT\"),\n  disp_cols = names(out),\n  main_title = \"Listing of Exposure to Study Drug\"\n)\n\nhead(lsting, 20)\n\nListing of Exposure to Study Drug\n\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                    Study Day   Study Day                                                          \nCenter/Subject ID       Visit         From         To         Treatment      Dose   Unit   Frequency      Route    \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n  BRA-1/id-105        SCREENING        -1          -1         A: Drug X      960     mg      ONCE      INTRAVENOUS \n                      BASELINE          1           1         A: Drug X      960     mg      ONCE      INTRAVENOUS \n                    WEEK 1 DAY 8        8           8         A: Drug X      720     mg      ONCE      SUBCUTANEOUS\n                    WEEK 2 DAY 15      15          15         A: Drug X      480     mg      ONCE      INTRAVENOUS \n                    WEEK 3 DAY 22      22          22         A: Drug X      480     mg      ONCE      INTRAVENOUS \n                    WEEK 4 DAY 29      29          29         A: Drug X      720     mg      ONCE      INTRAVENOUS \n                    WEEK 5 DAY 36      36          36         A: Drug X      720     mg      ONCE      INTRAVENOUS \n  BRA-1/id-134        SCREENING        -1          -1         A: Drug X      960     mg      ONCE      INTRAVENOUS \n                      BASELINE          1           1         A: Drug X      720     mg      ONCE      INTRAVENOUS \n                    WEEK 1 DAY 8        8           8         A: Drug X      720     mg      ONCE      INTRAVENOUS \n                    WEEK 2 DAY 15      15          15         A: Drug X      960     mg      ONCE      INTRAVENOUS \n                    WEEK 3 DAY 22      22          22         A: Drug X      720     mg      ONCE      INTRAVENOUS \n                    WEEK 4 DAY 29      29          29         A: Drug X      960     mg      ONCE      INTRAVENOUS \n                    WEEK 5 DAY 36      36          36         A: Drug X      960     mg      ONCE      INTRAVENOUS \n  BRA-1/id-141        SCREENING        -1          -1       C: Combination   960     mg      ONCE      INTRAVENOUS \n                      BASELINE          1           1       C: Combination   720     mg      ONCE      SUBCUTANEOUS\n                    WEEK 1 DAY 8        8           8       C: Combination   720     mg      ONCE      INTRAVENOUS \n                    WEEK 2 DAY 15      15          15       C: Combination   960     mg      ONCE      INTRAVENOUS \n                    WEEK 3 DAY 22      22          22       C: Combination   1200    mg      ONCE      INTRAVENOUS \n                    WEEK 4 DAY 29      29          29       C: Combination   1200    mg      ONCE      INTRAVENOUS \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] rlistings_0.2.4  tibble_3.2.1     formatters_0.5.2 scda_0.1.6      \n[5] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] vctrs_0.6.3       cli_3.6.1         knitr_1.44        rlang_1.1.1      \n [5] xfun_0.40         generics_0.1.3    jsonlite_1.8.7    glue_1.6.2       \n [9] backports_1.4.1   htmltools_0.5.6   brio_1.1.3        fansi_1.0.4      \n[13] rmarkdown_2.25    grid_4.3.1        evaluate_0.21     fastmap_1.1.1    \n[17] yaml_2.3.7        lifecycle_1.0.3   compiler_4.3.1    codetools_0.2-19 \n[21] htmlwidgets_1.6.2 testthat_3.1.10   pkgconfig_2.0.3   rstudioapi_0.15.0\n[25] digest_0.6.33     R6_2.5.1          tidyselect_1.2.0  utf8_1.2.3       \n[29] pillar_1.9.0      magrittr_2.0.3    checkmate_2.2.0   withr_2.5.0      \n[33] tools_4.3.1      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/efficacy/mmrmg02.html",
+    "href": "graphs/efficacy/mmrmg02.html",
+    "title": "MMRMG02",
+    "section": "",
+    "text": "Data Setup\nComparing Multiple Populations\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern.mmrm)\nlibrary(nestcolor)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\nadqs_f &lt;- adqs %&gt;%\n  dplyr::filter(PARAMCD == \"FKSI-FWB\" & !AVISIT %in% c(\"BASELINE\")) %&gt;%\n  droplevels() %&gt;%\n  dplyr::mutate(ARMCD = factor(ARMCD, levels = c(\"ARM B\", \"ARM A\", \"ARM C\"))) %&gt;%\n  dplyr::mutate(\n    AVISITN = rank(AVISITN) %&gt;%\n      as.factor() %&gt;%\n      as.numeric() %&gt;%\n      as.factor()\n  )\n\n# Simulation of groups.\nset.seed(2)\nadqs_f_with_groups &lt;- rbind(\n  within(\n    adqs_f[sample(1:nrow(adqs_f), size = 1 / 2 * nrow(adqs_f)), ],\n    group &lt;- \"subpopulation 1\"\n  ),\n  within(\n    adqs_f,\n    {\n      group &lt;- \"subpopulation 2\"\n      AVAL &lt;- AVAL + rnorm(length(AVAL), mean = 10, sd = 2)\n      USUBJID &lt;- paste0(USUBJID, \"-S2\")\n    }\n  )\n)\nadqs_f_with_groups$group &lt;- factor(adqs_f_with_groups$group)\n\n\n\n\nFor the following part, an MMRM model is fitted for the dataset and from this result forest plots are constructed for each set of subgroups, treatment arm, and visit that is of interest.\nFirst an MMRM model is fitted for the whole dataset.\n\nCodemmrm_results &lt;- fit_mmrm(\n  data = adqs_f_with_groups,\n  vars = list(\n    response = \"AVAL\",\n    covariates = c(),\n    id = \"USUBJID\",\n    arm = \"ARMCD\",\n    visit = \"AVISIT\"\n  ),\n  cor_struct = \"unstructured\",\n  weights_emmeans = \"equal\",\n  parallel = TRUE\n)\n\nWarning: `free_cores()` was deprecated in mmrm 0.1.6.\nℹ Please use the `omit` argument of `parallelly::availableCores()` instead.\nℹ The deprecated feature was likely used in the tern.mmrm package.\n  Please report the issue at\n  &lt;https://github.com/insightsengineering/tern.mmrm/issues&gt;.\n\n\nWarning: \"automatic\" optimizer was deprecated in mmrm 0.2.0.\nℹ please just omit optimizer argument\nℹ The deprecated feature was likely used in the mmrm package.\n  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.\n\n\nApplying the tern.mmrm::extract_mmrm_subgroups function prepares the obtained mmrm_results for a specific visit - in this case we use the SCREENING visit - and treatment arm relative to the reference arm. From these results a table is obtained using the tern.mmrm::tabulate_mmrm_subgroups function from which the graphic can be directly obtained with tern::g_forest.\nHere we compare ARM A with the reference arm, ARM B.\n\nCodedf_a &lt;- extract_mmrm_subgroups(\n  fit = mmrm_results,\n  visit = \"SCREENING\",\n  subgroups = c(\"group\", \"SEX\"),\n  treatment_arm = \"ARM A\"\n)\n\ntab_a &lt;- basic_table() %&gt;%\n  tabulate_mmrm_subgroups(\n    df = df_a,\n    vars = c(\"n_tot\", \"diff\", \"ci\", \"pval\")\n  )\n\nplot &lt;- g_forest(\n  tab_a,\n  logx = FALSE,\n  xlim = c(-5, 2.5),\n  x_at = c(-5, -2.5, 0, 2.5),\n  vline = 0\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.11] \n\n\nThen we compare ARM C with ARM B.\n\nCodedf_c &lt;- extract_mmrm_subgroups(\n  fit = mmrm_results,\n  visit = \"SCREENING\",\n  subgroups = c(\"group\", \"SEX\"),\n  treatment_arm = \"ARM C\"\n)\n\ntab_c &lt;- basic_table() %&gt;%\n  tabulate_mmrm_subgroups(\n    df = df_c,\n    vars = c(\"n_tot\", \"diff\", \"ci\", \"pval\")\n  )\n\nplot &lt;- g_forest(\n  tab_c,\n  logx = FALSE,\n  xlim = c(-5, 2.5),\n  x_at = c(-5, -2.5, 0, 2.5),\n  vline = 0\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.40] \n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  tern.mmrm_0.2.1  tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] gtable_0.3.4        TMB_1.9.6           xfun_0.40          \n [4] ggplot2_3.4.3       htmlwidgets_1.6.2   lattice_0.21-8     \n [7] numDeriv_2016.8-1.1 vctrs_0.6.3         tools_4.3.1        \n[10] Rdpack_2.5          generics_0.1.3      parallel_4.3.1     \n[13] sandwich_3.0-2      tibble_3.2.1        mmrm_0.2.2         \n[16] fansi_1.0.4         pkgconfig_2.0.3     Matrix_1.6-1.1     \n[19] checkmate_2.2.0     lifecycle_1.0.3     compiler_4.3.1     \n[22] stringr_1.5.0       brio_1.1.3          munsell_0.5.0      \n[25] codetools_0.2-19    htmltools_0.5.6     yaml_2.3.7         \n[28] pillar_1.9.0        tidyr_1.3.0         MASS_7.3-60        \n[31] multcomp_1.4-25     nlme_3.1-163        tidyselect_1.2.0   \n[34] digest_0.6.33       mvtnorm_1.2-3       stringi_1.7.12     \n[37] purrr_1.0.2         splines_4.3.1       cowplot_1.1.1      \n[40] fastmap_1.1.1       grid_4.3.1          colorspace_2.1-0   \n[43] cli_3.6.1           survival_3.5-7      utf8_1.2.3         \n[46] broom_1.0.5         TH.data_1.1-2       scales_1.2.1       \n[49] backports_1.4.1     estimability_1.4.1  rmarkdown_2.25     \n[52] emmeans_1.8.8       zoo_1.8-12          coda_0.19-4        \n[55] evaluate_0.21       knitr_1.44          rbibutils_2.2.15   \n[58] testthat_3.1.10     rlang_1.1.1         Rcpp_1.0.11        \n[61] xtable_1.8-4        glue_1.6.2          rstudioapi_0.15.0  \n[64] jsonlite_1.8.7      R6_2.5.1           \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/efficacy/mmrmg01.html",
+    "href": "graphs/efficacy/mmrmg01.html",
+    "title": "MMRMG01",
+    "section": "",
+    "text": "Given an MMRM fitted with s_mmrm, g_mmrm_lsmeans displays for each visit the adjusted means within group and/or difference in adjusted means between groups. g_mmrm_diagnostic displays marginal residual plots for evaluating model fit.\n\n\nData Setup and  Model Fitting\nLeast Squares Means:  Estimates Within Groups\nLeast Squares Means:  Contrasts Between Groups\nModel Diagnostics: Marginal  Fitted Values vs. Residuals\nModel Diagnostics: Normality  of Marginal Residuals\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern.mmrm)\nlibrary(scda)\nlibrary(nestcolor)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\nadqs_f &lt;- adqs %&gt;%\n  dplyr::filter(PARAMCD == \"FKSI-FWB\" & !AVISIT %in% c(\"BASELINE\")) %&gt;%\n  droplevels() %&gt;%\n  dplyr::mutate(ARM = factor(ARM, levels = c(\"B: Placebo\", \"A: Drug X\", \"C: Combination\"))) %&gt;%\n  dplyr::mutate(AVISITN = rank(AVISITN) %&gt;% as.factor() %&gt;% as.numeric() %&gt;% as.factor())\n\nmmrm_results &lt;- fit_mmrm(\n  vars = list(\n    response = \"AVAL\",\n    covariates = c(\"STRATA2\"),\n    id = \"USUBJID\",\n    arm = \"ARM\",\n    visit = \"AVISIT\"\n  ),\n  data = adqs_f\n)\n\nWarning: \"automatic\" optimizer was deprecated in mmrm 0.2.0.\nℹ please just omit optimizer argument\nℹ The deprecated feature was likely used in the mmrm package.\n  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.\n\n\n\n\nConsidering the treatment variable in the model\n\nCodeplot &lt;- g_mmrm_lsmeans(\n  mmrm_results,\n  select = \"estimates\",\n  xlab = \"Visit\"\n)\nplot\n\n\n\n\nConsidering the treatment variable in the model, with lines\n\nCodeplot &lt;- g_mmrm_lsmeans(\n  mmrm_results,\n  select = \"estimates\",\n  xlab = \"Visit\",\n  show_lines = TRUE\n)\nplot\n\n\n\n\nConsidering the treatment variable in the model, with statistics table\n\nCodeplot &lt;- g_mmrm_lsmeans(\n  mmrm_results,\n  select = \"estimates\",\n  xlab = \"Visit\",\n  table_stats = c(\"n\", \"estimate\", \"se\", \"ci\"),\n  table_font_size = 4,\n  table_rel_height = 0.6\n)\nplot\n\n\n\n\n\n\n\nUsers can choose to display both estimates and contrasts together by running g_mmrm_lsmeans(mmrm_results).\n\nCodeplot &lt;- g_mmrm_lsmeans(\n  mmrm_results,\n  select = \"contrasts\",\n  titles = c(contrasts = \"Contrasts of FKSI-FWB means\"),\n  xlab = \"Visit\"\n)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_mmrm_diagnostic(mmrm_results)\nplot\n\n\n\n\n\n\n\nCodeplot &lt;- g_mmrm_diagnostic(mmrm_results, type = \"q-q-residual\")\nplot\n\n\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\") %&gt;%\n  dplyr::filter(ABLFL != \"Y\" & ABLFL2 != \"Y\") %&gt;%\n  dplyr::filter(AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\")) %&gt;%\n  dplyr::mutate(\n    AVISIT = as.factor(AVISIT),\n    AVISITN = rank(AVISITN) %&gt;%\n      as.factor() %&gt;%\n      as.numeric() %&gt;%\n      as.factor() # making consecutive numeric factor\n  )\n\narm_ref_comp &lt;- list(\n  ARMCD = list(\n    ref = \"ARM A\",\n    comp = c(\"ARM B\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADQS\", adqs),\n    code = '\n    ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADQS &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\") %&gt;%\n              dplyr::filter(ABLFL != \"Y\" & ABLFL2 != \"Y\") %&gt;%\n              dplyr::filter(AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\")) %&gt;%\n              dplyr::mutate(\n                AVISIT = as.factor(AVISIT),\n                AVISITN = rank(AVISITN) %&gt;%\n                  as.factor() %&gt;%\n                  as.numeric() %&gt;%\n                  as.factor() # making consecutive numeric factor\n              )\n    ',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_a_mmrm(\n      label = \"MMRM\",\n      dataname = \"ADQS\",\n      aval_var = choices_selected(c(\"AVAL\", \"CHG\"), \"AVAL\"),\n      id_var = choices_selected(c(\"USUBJID\", \"SUBJID\"), \"USUBJID\"),\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARMCD\"),\n      visit_var = choices_selected(c(\"AVISIT\", \"AVISITN\"), \"AVISIT\"),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        choices = value_choices(adqs, \"PARAMCD\", \"PARAM\"),\n        selected = \"FKSI-FWB\"\n      ),\n      cov_var = choices_selected(c(\"BASE\", \"AGE\", \"SEX\", \"BASE:AVISIT\"), NULL),\n      conf_level = choices_selected(c(0.95, 0.9, 0.8), 0.95)\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:47:41.5751 pid:4991 token:[] teal.modules.clinical Initializing tm_a_mmrm\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              scda_0.1.6                  \n [9] tern.mmrm_0.2.1              tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] Rdpack_2.5            mmrm_0.2.2            tern.gee_0.1.0       \n [4] logger_0.2.2          testthat_3.1.10       sandwich_3.0-2       \n [7] rlang_1.1.1           multcomp_1.4-25       compiler_4.3.1       \n[10] callr_3.7.3           vctrs_0.6.3           stringr_1.5.0        \n[13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      \n[16] ellipsis_0.3.2        fontawesome_0.5.2     labeling_0.4.3       \n[19] utf8_1.2.3            promises_1.2.1        rmarkdown_2.25       \n[22] ps_1.7.5              purrr_1.0.2           xfun_0.40            \n[25] cachem_1.0.8          teal.reporter_0.2.1   jsonlite_1.8.7       \n[28] later_1.3.1           broom_1.0.5           parallel_4.3.1       \n[31] R6_2.5.1              bslib_0.5.1           stringi_1.7.12       \n[34] brio_1.1.3            jquerylib_0.1.4       numDeriv_2016.8-1.1  \n[37] estimability_1.4.1    Rcpp_1.0.11           assertthat_0.2.1     \n[40] knitr_1.44            zoo_1.8-12            teal.logger_0.1.3    \n[43] httpuv_1.6.11         Matrix_1.6-1.1        splines_4.3.1        \n[46] tidyselect_1.2.0      rstudioapi_0.15.0     yaml_2.3.7           \n[49] TMB_1.9.6             codetools_0.2-19      processx_3.8.2       \n[52] teal.widgets_0.4.0    lattice_0.21-8        tibble_3.2.1         \n[55] withr_2.5.0           coda_0.19-4           evaluate_0.21        \n[58] survival_3.5-7        shinycssloaders_1.0.0 pillar_1.9.0         \n[61] checkmate_2.2.0       shinyjs_2.1.0         generics_0.1.3       \n[64] ggplot2_3.4.3         munsell_0.5.0         scales_1.2.1         \n[67] xtable_1.8-4          glue_1.6.2            emmeans_1.8.8        \n[70] tools_4.3.1           webshot_0.5.5         mvtnorm_1.2-3        \n[73] cowplot_1.1.1         grid_4.3.1            tidyr_1.3.0          \n[76] rbibutils_2.2.15      colorspace_2.1-0      nlme_3.1-163         \n[79] cli_3.6.1             fansi_1.0.4           geepack_1.3.9        \n[82] gtable_0.3.4          sass_0.4.7            digest_0.6.33        \n[85] TH.data_1.1-2         htmlwidgets_1.6.2     farver_2.1.1         \n[88] memoise_2.0.1         htmltools_0.5.6       lifecycle_1.0.3      \n[91] shinyWidgets_0.8.0    mime_0.12             MASS_7.3-60          \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkcg03.html",
+    "href": "graphs/pharmacokinetic/pkcg03.html",
+    "title": "PKCG03",
+    "section": "",
+    "text": "Data Setup\nPlot in Linear Scale\nPlot in Log Scale\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\nadsl_f &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n  filter(SAFFL == \"Y\" & ARM != \"B: Placebo\") %&gt;%\n  df_explicit_na()\n\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\") %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID)) %&gt;%\n  filter(PARAM == \"Plasma Drug X\") %&gt;%\n  droplevels() %&gt;%\n  df_explicit_na()\n\n\n\n\n\nCodeuse_title &lt;- \"Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, \\nPK Evaluable Patients\"\nuse_subtitle &lt;- \"Analyte:\"\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nresult &lt;- g_lineplot(\n  df = adpc,\n  variables = control_lineplot_vars(\n    x = \"NFRLT\",\n    y = \"AVAL\",\n    strata = \"ARM\",\n    paramcd = \"PARAM\",\n    y_unit = \"AVALU\"\n  ),\n  alt_counts_df = adsl_f,\n  y_lab = \"Concentration\",\n  y_lab_add_paramcd = FALSE,\n  y_lab_add_unit = TRUE,\n  interval = \"mean_sdi\",\n  whiskers = c(\"mean_sdi_lwr\", \"mean_sdi_upr\"),\n  title = use_title,\n  subtitle = use_subtitle,\n  caption = use_footnote,\n  ggtheme = theme_nest()\n)\n\nplot &lt;- result + theme(plot.caption = element_text(hjust = 0))\nplot\n\n\n\n\n\n\n\nCodeuse_title &lt;- \"Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, \\nPK Evaluable Patients\"\nuse_subtitle &lt;- \"Analyte:\"\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nadpc &lt;- adpc %&gt;%\n  mutate(avalog = ifelse(AVAL != 0, AVAL, 0.001))\n\nresult &lt;- g_lineplot(\n  df = adpc,\n  variables = control_lineplot_vars(\n    x = \"NFRLT\",\n    y = \"avalog\",\n    strata = \"ARM\",\n    paramcd = \"PARAM\",\n    y_unit = \"AVALU\"\n  ),\n  alt_counts_df = adsl_f,\n  y_lab = \"Concentration\",\n  y_lab_add_paramcd = FALSE,\n  y_lab_add_unit = TRUE,\n  interval = \"mean_sdi\",\n  whiskers = c(\"mean_sdi_lwr\", \"mean_sdi_upr\"),\n  title = use_title,\n  subtitle = use_subtitle,\n  caption = use_footnote,\n  ggtheme = theme_nest()\n)\n\nplot &lt;- result + theme(plot.caption = element_text(hjust = 0)) +\n  ggplot2::scale_y_log10(breaks = c(0.001, 0.01, 0.1, 1, 10), label = c(0.001, 0.01, 0.1, 1, 10))\n\nScale for y is already present.\nAdding another scale for y, which will replace the existing scale.\n\nCodeplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   \n [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    \n [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       \n[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     \n[17] codetools_0.2-19  Rdpack_2.5        cli_3.6.1         rlang_1.1.1      \n[21] rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1     withr_2.5.0      \n[25] yaml_2.3.7        tools_4.3.1       checkmate_2.2.0   colorspace_2.1-0 \n[29] forcats_1.0.0     broom_1.0.5       vctrs_0.6.3       R6_2.5.1         \n[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     \n[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     \n[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     \n[45] htmltools_0.5.6   rmarkdown_2.25    labeling_0.4.3    testthat_3.1.10  \n[49] compiler_4.3.1   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkcg01.html",
+    "href": "graphs/pharmacokinetic/pkcg01.html",
+    "title": "PKCG01",
+    "section": "",
+    "text": "Data Setup\nPlot in Linear Scale\nPlot in Log Scale\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\nadpc &lt;- synthetic_cdisc_dataset(\"latest\", \"adpc\")\n\n\n\n\n\nCodeadpc_a &lt;- adpc %&gt;%\n  filter(\n    PARAM == \"Plasma Drug X\",\n    ARMCD == \"ARM A\"\n  ) %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID))\n\nuse_title &lt;- \"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by\\nPatient: PK Evaluable Patients\"\nuse_subtitle &lt;- \"Analyte: Plasma Drug X (ug/mL) \\nTreatment Group: ARM A\"\nuse_footnote &lt;- \"Program: \\nOutput:\"\n\nresult &lt;- g_ipp(\n  df = adpc_a,\n  xvar = \"NFRLT\",\n  yvar = \"AVAL\",\n  xlab = \"Norminal Time from First Dose (hr)\",\n  ylab = \"Concentration (ug/mL)\",\n  id_var = \"Patient_ID\",\n  add_baseline_hline = F,\n  yvar_baseline = \"AVAL\", #  yvar_baseline cannot be NA or ignore\n  title = use_title,\n  subtitle = use_subtitle,\n  caption = use_footnote,\n  plotting_choices = \"separate_by_obs\"\n)\nplot &lt;- result[[1]] # only show the first subject\nplot\n\n\n\n\n\n\n\nCodeadpc_a &lt;- adpc %&gt;%\n  filter(\n    PARAM == \"Plasma Drug X\",\n    ARMCD == \"ARM A\"\n  ) %&gt;%\n  mutate(avalog = ifelse(AVAL != 0, AVAL, 0.001)) %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID))\n\nuse_title2 &lt;- \"Plot of Plasma Drug X (ug/mL) Concentrations Over Time by\\nPatient: PK Evaluable Patients\"\nuse_subtitle2 &lt;- \"Analyte: Plasma Drug X (ug/mL) \\nTreatment Group: ARM A\"\nuse_footnote2 &lt;- \"Program: \\nOutput:\"\n\nresult &lt;- g_ipp(\n  df = adpc_a,\n  xvar = \"NFRLT\",\n  yvar = \"avalog\",\n  xlab = \"Norminal Time from First Dose (hr)\",\n  ylab = \"Concentration (ug/mL)\",\n  id_var = \"Patient_ID\",\n  add_baseline_hline = F,\n  yvar_baseline = \"AVAL\", #  yvar_baseline cannot be NA or ignore\n  title = use_title2,\n  subtitle = use_subtitle2,\n  caption = use_footnote2,\n  plotting_choices = \"separate_by_obs\"\n)\nplot &lt;- result[[1]] + ggplot2::scale_y_log10(breaks = c(0.001, 0.01, 0.1, 1, 10), label = c(0.001, 0.01, 0.1, 1, 10))\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] R6_2.5.1          labeling_0.4.3    generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        farver_2.1.1      codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkpg02.html",
+    "href": "graphs/pharmacokinetic/pkpg02.html",
+    "title": "PKPG02",
+    "section": "",
+    "text": "Data Setup\nSummary of Pharmacokinetic  Parameters – Plasma\nSummary of Plasma Pharmacokinetic  Parameters with Median Points\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\n# need adex for dose info and adpp for AUC max info\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\nadpp_a &lt;- adpp %&gt;%\n  filter(\n    PPSPEC == \"Plasma\",\n    AVISITN == \"1\",\n    PARAMCD == \"AUCIFO\"\n  ) %&gt;%\n  mutate(AUCinf = AVAL)\n\nadex_a &lt;- adex %&gt;%\n  filter(\n    AVISITN == \"1\",\n    PARAMCD == \"DOSE\"\n  ) %&gt;%\n  mutate(Dose = AVAL) %&gt;%\n  select(USUBJID, Dose)\n\n# join the dose information to the adpp table\nadpp_adex &lt;- left_join(adpp_a, adex_a, by = \"USUBJID\") %&gt;%\n  group_by(`ARM`) %&gt;%\n  mutate(count = paste0(`ARM`, \" (\", n(), \")\"))\n\n# set x and y variable names\nx_var &lt;- \"Dose\"\ny_var &lt;- \"AUCinf\"\n\n\n\n\n\nCode# calculate Summary Statistics (mean and sd) for each group\nSummaryStat &lt;- adpp_adex %&gt;%\n  group_by(Dose = as.factor(Dose)) %&gt;%\n  summarise(AUCsd = sd(AUCinf), meanAUC = mean(AUCinf))\nSummaryStat$Dose &lt;- as.numeric(as.character(SummaryStat$Dose))\n\n# generate linear model\nmod1 &lt;- lm(log(AUCinf) ~ log(Dose), adpp_adex)\n\n# obtain linear model coefficient values\ncf &lt;- round(coef(mod1), 2)\n\n# generate linear model equation\neq &lt;- paste0(\n  \"y = \", cf[1],\n  ifelse(sign(cf[2]) == 1, \" + \", \" - \"), abs(cf[2]), \" x , \",\n  \"R²\",\n  \" = \",\n  signif(summary(mod1)$adj.r.squared, 3)\n)\n\nplot &lt;- ggplot(adpp_adex, aes(x = .data[[x_var]], y = .data[[y_var]])) +\n  annotate(geom = \"text\", x = min(adpp_adex[[x_var]]), y = max(adpp_adex[[y_var]]), label = eq, hjust = 0.1) +\n  geom_point(size = 1, aes(color = factor(`count`))) +\n  scale_x_continuous(\n    name = \"Dose (mg/mL)\",\n    breaks = unique(adpp_adex$Dose)\n  ) +\n  scale_y_continuous(\n    name = paste(y_var, adpp_a$AVALU),\n    trans = \"log\",\n    breaks = exp(ceiling(seq(\n      from = min(log(adpp_adex$AUCinf)), to = max(log(adpp_adex$AUCinf)),\n      by = 1\n    ))),\n    labels = as.character(ceiling(seq(\n      from = min(log(adpp_adex$AUCinf)),\n      to = max(log(adpp_adex$AUCinf)), by = 1\n    )))\n  ) +\n  geom_smooth(method = \"lm\", formula = y ~ x, se = F, color = \"black\", linewidth = 0.5) +\n  # Display error bars for each dosing group (this will only appear if the sd is less than the mean)\n  geom_errorbar(\n    data = SummaryStat, aes(x = `Dose`, y = `meanAUC`, ymin = `meanAUC` - `AUCsd`, ymax = `meanAUC` + AUCsd), width = .05,\n    position = position_dodge(.1)\n  ) +\n  geom_point(data = SummaryStat, aes(x = Dose, y = meanAUC, size = 1), shape = 2, show.legend = FALSE) +\n  ggtitle(paste(\n    \"Dose-Proportionality Plot of Serum\", as.character(unique(adex$TRT01P)),\n    y_var, \"in\", adpp_a$AVALU\n  ), subtitle = \"Summary of serum PK parameters by treatment\") +\n  labs(color = \"Treatment Arm\") +\n  theme_nest()\n\nplot\n\n\n\n\n\n\n\nCode# calculate median for each group if preferred\nSummaryStat &lt;- adpp_adex %&gt;%\n  group_by(Dose = as.factor(Dose)) %&gt;%\n  summarise(medAUC = median(AUCinf))\nSummaryStat$Dose &lt;- as.numeric(as.character(SummaryStat$Dose))\n\nplot &lt;- ggplot(adpp_adex, aes(x = .data[[x_var]], y = .data[[y_var]])) +\n  annotate(geom = \"text\", x = min(adpp_adex[[x_var]]), y = max(adpp_adex[[y_var]]), label = eq, hjust = 0.1) +\n  geom_point(size = 1, aes(color = factor(`count`))) +\n  geom_smooth(method = \"lm\", formula = y ~ x, se = F, color = \"black\", linewidth = 0.5) +\n  geom_point(data = SummaryStat, aes(x = Dose, y = medAUC, size = 1), shape = 2, show.legend = FALSE) +\n  ggtitle(paste(\"Dose-Proportionality Plot of Serum\", as.character(unique(adex$TRT01P)), y_var, \"in\", adpp_a$AVALU), subtitle = \"Summary of serum PK parameters by treatment\") +\n  labs(color = \"Treatment Arm\") +\n  scale_y_continuous(\n    name = paste(y_var, adpp_a$AVALU),\n    trans = \"log\",\n    breaks = exp(ceiling(seq(from = min(log(adpp_adex$AUCinf)), to = max(log(adpp_adex$AUCinf)), by = 1))),\n    labels = as.character(ceiling(seq(from = min(log(adpp_adex$AUCinf)), to = max(log(adpp_adex$AUCinf)), by = 1)))\n  ) +\n  scale_x_continuous(\n    name = \"Dose (mg/mL)\",\n    breaks = unique(adpp_adex$Dose)\n  ) +\n  theme_nest()\n\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  ggplot2_3.4.3    dplyr_1.1.3      scda_0.1.6      \n[5] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] utf8_1.2.3        generics_0.1.3    tidyr_1.3.0       lattice_0.21-8   \n [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    \n [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       \n[13] survival_3.5-7    mgcv_1.9-0        purrr_1.0.2       fansi_1.0.4      \n[17] scales_1.2.1      codetools_0.2-19  Rdpack_2.5        cli_3.6.1        \n[21] rlang_1.1.1       rbibutils_2.2.15  munsell_0.5.0     splines_4.3.1    \n[25] withr_2.5.0       yaml_2.3.7        tools_4.3.1       checkmate_2.2.0  \n[29] colorspace_2.1-0  broom_1.0.5       vctrs_0.6.3       R6_2.5.1         \n[33] lifecycle_1.0.3   htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     \n[37] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     \n[41] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     \n[45] htmltools_0.5.6   nlme_3.1-163      rmarkdown_2.25    testthat_3.1.10  \n[49] compiler_4.3.1   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/pharmacokinetic/pkpg06.html",
+    "href": "graphs/pharmacokinetic/pkpg06.html",
+    "title": "PKPG06",
+    "section": "",
+    "text": "Data Setup\nPlot with Whiskers at ±1.5  Times Inter-Quartile Range\nPlot with Whiskers at  Minimum and Maximum Values\nPlot with Whiskers at  5th and 95th Percentiles\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(ggplot2)\nlibrary(tidyr)\nlibrary(tern)\nlibrary(nestcolor)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\n# Filter NAs\nadpp &lt;- adpp %&gt;%\n  filter(PPSPEC != \"NA\" & PARAM != \"NA\" & PPCAT != \"NA\") %&gt;%\n  filter(PARAMCD == \"CMAX\" | PARAMCD == \"AUCIFO\", AVISITN == 1)\n\n# filter data by PPCAT and calculate ratio\nanl_x &lt;- adpp %&gt;%\n  filter(PPCAT %in% c(\"Metabolite Drug X\", \"Plasma Drug X\")) %&gt;%\n  pivot_wider(\n    id_cols = c(USUBJID, ACTARM, PARAMCD, AVISIT),\n    names_from = PPCAT,\n    values_from = AVAL\n  ) %&gt;%\n  dplyr::mutate(ratio = `Metabolite Drug X` / `Plasma Drug X`) %&gt;%\n  filter(!is.na(ratio), ratio != Inf)\n\nanl_y &lt;- adpp %&gt;%\n  filter(PPCAT %in% c(\"Metabolite Drug Y\", \"Plasma Drug Y\")) %&gt;%\n  pivot_wider(\n    id_cols = c(USUBJID, ACTARM, PARAMCD, AVISIT),\n    names_from = PPCAT,\n    values_from = AVAL\n  ) %&gt;%\n  dplyr::mutate(ratio = `Metabolite Drug Y` / `Plasma Drug Y`) %&gt;%\n  filter(!is.na(ratio), ratio != Inf)\n\n# functions to calculate custom quantiles and outliers\nquantiles &lt;- function(x) {\n  quant &lt;- quantile(x, probs = c(0.05, 0.25, 0.5, 0.75, 0.95))\n  names(quant) &lt;- c(\"ymin\", \"lower\", \"middle\", \"upper\", \"ymax\")\n  quant\n}\n\noutliers &lt;- function(x) {\n  return(x &lt; quantile(x, 0.05) | x &gt; quantile(x, 0.95))\n}\n\n\n\n\nDrug X Boxplot\n\nCodeplot &lt;- ggplot(anl_x, aes(x = PARAMCD, y = ratio, fill = ACTARM, label = USUBJID)) +\n  geom_boxplot(outlier.size = 2) +\n  stat_boxplot(geom = \"errorbar\") +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(0.75)) +\n  geom_text(\n    data = . %&gt;% dplyr::group_by(PARAMCD, ACTARM) %&gt;% dplyr::filter(ratio %in% boxplot.stats(ratio)$out),\n    aes(x = PARAMCD, y = ratio, label = USUBJID, col = factor(ACTARM)),\n    size = 3, hjust = -0.2, position = position_dodge(0.75), show.legend = F\n  ) +\n  labs(\n    title = \"Boxplot of Metabolite to Parent Ratios by Treatment\",\n    subtitle = paste0(\"Analyte: Plasma Drug X, Metabolite Drug X \", \"\\nPK Parameter: \", as.character(paste(unique(anl_x$PARAMCD), collapse = \", \")), \"\\nVisit: \", as.character((unique(anl_x$AVISIT)))),\n    caption = \"Program: \\nOutput:\",\n    x = \"Parameter\",\n    y = \"Metabolite to Parent Ratio\"\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\n# PKPG06\nplot\n\n\n\n\nDrug Y Boxplot\n\nCodeplot &lt;- ggplot(anl_y, aes(x = PARAMCD, y = ratio, fill = ACTARM, label = USUBJID)) +\n  geom_boxplot(outlier.size = 2) +\n  stat_boxplot(geom = \"errorbar\") +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(0.75)) +\n  geom_text(\n    data = . %&gt;% dplyr::group_by(PARAMCD, ACTARM) %&gt;% dplyr::filter(ratio %in% boxplot.stats(ratio)$out),\n    aes(x = PARAMCD, y = ratio, label = USUBJID, color = ACTARM),\n    size = 3, hjust = -0.2, position = position_dodge(0.75), show.legend = F\n  ) +\n  labs(\n    title = \"Boxplot of Metabolite to Parent Ratios by Treatment\",\n    subtitle = paste0(\"Analyte: Plasma Drug Y, Metabolite Drug Y \", \"\\nPK Parameter: \", as.character(paste(unique(anl_y$PARAMCD), collapse = \", \")), \"\\nVisit: \", as.character((unique(anl_y$AVISIT)))),\n    caption = \"Program: \\nOutput:\",\n    x = \"Parameter\",\n    y = \"Metabolite to Parent Ratio\"\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\n# result\nplot\n\n\n\n\n\n\n\n\nCode# whiskers are formed with the minimum and maximum values\nplot &lt;- ggplot(anl_x, aes(x = PARAMCD, y = ratio, fill = ACTARM, label = USUBJID)) +\n  geom_boxplot(outlier.size = 0) +\n  stat_boxplot(geom = \"errorbar\", coef = NULL) +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(0.75)) +\n  labs(\n    title = \"Boxplot of Metabolite to Parent Ratios by Treatment\",\n    subtitle = paste0(\"Analyte: Plasma Drug X, Metabolite Drug X \", \"\\nPK Parameter: \", as.character(paste(unique(anl_x$PARAMCD), collapse = \", \")), \"\\nVisit: \", as.character((unique(anl_x$AVISIT)))),\n    caption = \"Program:\\nOutput:\",\n    x = \"Parameter\",\n    y = \"Metabolite to Parent Ratio\"\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\n# result\nplot\n\n\n\n\n\n\n\nCodeanl_x_without_outliers &lt;- anl_x %&gt;%\n  dplyr::group_by(PARAMCD, ACTARM) %&gt;%\n  dplyr::mutate(outlier = ifelse(outliers(ratio), ratio, as.numeric(NA)))\nplot &lt;- ggplot(anl_x, aes(factor(PARAMCD), ratio, fill = factor(ACTARM), label = USUBJID)) +\n  stat_summary(\n    fun.data = quantiles, geom = \"boxplot\",\n    position = position_dodge(1)\n  ) +\n  stat_summary(geom = \"point\", fun = \"mean\", col = \"black\", size = 5, shape = 8, position = position_dodge(1)) +\n  stat_summary(\n    fun.data = quantiles, geom = \"errorbar\",\n    position = position_dodge(1)\n  ) +\n  geom_point(\n    data = anl_x_without_outliers,\n    aes(x = PARAMCD, y = outlier), na.rm = T,\n    size = 2, position = position_dodge(1), show.legend = F\n  ) +\n  geom_text(\n    data = anl_x_without_outliers,\n    aes(x = PARAMCD, y = outlier, label = USUBJID, color = ACTARM), na.rm = T,\n    size = 3, hjust = -0.2, vjust = 1, position = position_dodge(1), show.legend = F\n  ) +\n  labs(\n    title = \"Boxplot of Metabolite to Parent Ratios by Treatment\",\n    subtitle = paste0(\"Analyte: Plasma Drug X, Metabolite Drug X \", \"\\nPK Parameter: \", as.character(paste(unique(anl_x$PARAMCD), collapse = \", \")), \"\\nVisit: \", as.character((unique(anl_x$AVISIT)))),\n    caption = \"Program: \\nOutput:\",\n    x = \"Parameter\",\n    y = \"Metabolite to Parent Ratio\"\n  ) +\n  theme(plot.caption = element_text(hjust = 0)) +\n  theme_nest()\n\n# result\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] nestcolor_0.1.2  tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 tidyr_1.3.0      ggplot2_3.4.3    scda_0.1.6      \n[9] dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  splines_4.3.1     scales_1.2.1     \n [9] yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8    R6_2.5.1         \n[13] labeling_0.4.3    generics_0.1.3    knitr_1.44        rbibutils_2.2.15 \n[17] htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0   tibble_3.2.1     \n[21] munsell_0.5.0     pillar_1.9.0      rlang_1.1.1       utf8_1.2.3       \n[25] testthat_3.1.10   broom_1.0.5       xfun_0.40         cli_3.6.1        \n[29] withr_2.5.0       Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        farver_2.1.1      codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  rmarkdown_2.25    purrr_1.0.2      \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/kmg01.html",
+    "href": "graphs/other/kmg01.html",
+    "title": "KMG01",
+    "section": "",
+    "text": "Data Setup\nStandard Plot\nPlot of Failures\nPlot Without  Comparative Statistics\nPlot Without  Censoring Marks\nPlot Modifying  Censoring Marks\nPlot Modifying Options for Statistics,  Tie Handling, Stratification, etc.\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(nestcolor)\n\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\nanl &lt;- adtte %&gt;%\n  dplyr::filter(PARAMCD == \"OS\") %&gt;%\n  dplyr::mutate(is_event = CNSR == 0)\nvariables &lt;- list(tte = \"AVAL\", is_event = \"is_event\", arm = \"ARMCD\")\n\n\n\n\n\nCodeplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  xlab = \"Time (Days)\",\n  ylim = c(0, 1),\n  annot_coxph = TRUE\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.162] \n\n\n\n\n\nCodeplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  xlab = \"Time (Days)\",\n  yval = \"Failure\",\n  ylim = c(0, 1),\n  annot_surv_med = TRUE,\n  annot_coxph = TRUE,\n  font_size = 7.5,\n  position_coxph = c(0.3, 0),\n  position_surv_med = c(0.9, 0.3)\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.312] \n\n\n\n\n\nCodeplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  xlab = \"Time (Days)\",\n  ylim = c(0, 1),\n  annot_surv_med = TRUE\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.436] \n\n\n\n\n\nCodeplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  censor_show = FALSE,\n  xlab = \"Time (Days)\",\n  ylim = c(0, 1),\n  annot_coxph = TRUE\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.572] \n\n\n\n\n\nCodeplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  pch = 1,\n  size = 2,\n  xlab = \"Time (Days)\",\n  ylim = c(0, 1),\n  annot_coxph = TRUE\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.722] \n\n\n\n\n\nCodevariables$strat &lt;- c(\"STRATA1\", \"STRATA2\")\nplot &lt;- g_km(\n  df = anl,\n  variables = variables,\n  control_surv = control_surv_timepoint(conf_level = 0.8),\n  xlab = \"Time (Days)\",\n  ylim = c(0, 1),\n  annot_coxph = TRUE,\n  control_coxph_pw = control_coxph(\n    pval_method = \"wald\",\n    ties = \"breslow\",\n    conf_level = 0.8\n  )\n)\n\n\n\nCodeplot\n\ngTree[GRID.gTree.872] \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADTTE\", ADTTE, code = 'ADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_g_km(\n      label = \"KM PLOT\",\n      plot_height = c(600, 100, 2000),\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(\n        variable_choices(ADSL, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      paramcd = choices_selected(\n        value_choices(ADTTE, \"PARAMCD\", \"PARAM\"),\n        \"OS\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      strata_var = choices_selected(\n        variable_choices(ADSL, c(\"SEX\", \"BMRKR2\")),\n        \"SEX\"\n      ),\n      facet_var = choices_selected(\n        variable_choices(ADSL, c(\"SEX\", \"BMRKR2\")),\n        NULL\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:51:12.4556 pid:5913 token:[] teal.modules.clinical Initializing tm_g_km\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              dplyr_1.1.3                 \n [9] scda_0.1.6                   tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        \n [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        \n [7] digest_0.6.33         estimability_1.4.1    mime_0.12            \n[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       \n[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       \n[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          \n[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           \n[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      \n[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   \n[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[34] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[37] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[40] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[43] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[49] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[52] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[55] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[58] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[61] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[64] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[67] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[70] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[73] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[76] broom_1.0.5           teal.reporter_0.2.1   bslib_0.5.1          \n[79] httpuv_1.6.11         Rcpp_1.0.11           coda_0.19-4          \n[82] gridExtra_2.3         nlme_3.1-163          checkmate_2.2.0      \n[85] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/brg01.html",
+    "href": "graphs/other/brg01.html",
+    "title": "BRG01",
+    "section": "",
+    "text": "Data Setup\nPlot of Frequency\nPlot of Percentage\nPlot of Frequency with  Total Number of Subjects\nPlot of Frequency  with Horizontal Bars\nPlot of Percentage  and Confidence Intervals\nPlot of Percentage by  Treatment and Covariate\nPlot of Percentage by  Covariate and Treatment\nPlot of Percentage  with Mean and Median\nPlot of Categorical  Variable\nteal App\nReproducibility\n\n\n\n\nCodelibrary(binom)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(scda)\nlibrary(tidyr)\nlibrary(tern)\nlibrary(nestcolor)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# filtered population\npatpop_df &lt;- adsl %&gt;%\n  group_by(STUDYID) %&gt;%\n  summarise(patpop = n())\npatpop &lt;- setNames(patpop_df$patpop, patpop_df$STUDYID)\ndenom &lt;- patpop_df$patpop\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\") %&gt;%\n  mutate(AETOXGRC = as.character(AETOXGR))\nattributes(adae$AETOXGRC)$label &lt;- \"Analysis Toxicity Grade (C)\"\nvl_ae &lt;- var_labels(adae)\n\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\nvl_lb &lt;- var_labels(adlb)\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESER == \"Y\")\nanl &lt;- anl[!duplicated(anl$USUBJID), ]\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]])) +\n  geom_bar(fill = getOption(\"ggplot2.discrete.fill\")[1]) +\n  geom_text(stat = \"count\", aes(label = ggplot2::after_stat(count)), vjust = -.5) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Frequency\")\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESOC == \"cl A\")\n\nanl &lt;- anl[!duplicated(anl$USUBJID), ] %&gt;%\n  group_by(ACTARM) %&gt;%\n  summarise(n = n()) %&gt;%\n  mutate(N = patpop) %&gt;%\n  mutate(N = as.numeric(N)) %&gt;%\n  mutate(pct = round((n / N) * 100, 2))\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]])) +\n  geom_col(aes(x = ACTARM, y = pct), fill = getOption(\"ggplot2.discrete.fill\")[1]) +\n  scale_y_continuous(labels = scales::comma) +\n  geom_text(aes(y = pct, label = pct), stat = \"identity\", vjust = -0.5) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percent\")\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESOC == \"cl A\")\nanl &lt;- anl[!duplicated(anl$USUBJID), ]\n\nanl &lt;- anl %&gt;%\n  group_by(ACTARM) %&gt;%\n  mutate(n = n()) %&gt;%\n  mutate(xvarlabel = paste0(ACTARM, \"\\n\\nN = \", n))\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"xvarlabel\"]])) +\n  geom_bar(fill = getOption(\"ggplot2.discrete.fill\")[1]) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Frequency\")\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESER == \"Y\")\nanl &lt;- anl[!duplicated(anl$USUBJID), ]\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]])) +\n  geom_bar(fill = getOption(\"ggplot2.discrete.fill\")[1]) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Frequency\") +\n  coord_flip()\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adlb %&gt;%\n  filter(PARAMCD == \"ALT\" & ANRIND == \"HIGH\")\nanl &lt;- anl[!duplicated(anl$USUBJID), ]\n\npatpop5 &lt;- as.data.frame(table(adsl$ACTARM)) %&gt;%\n  mutate(ACTARM = as.vector(Var1)) %&gt;%\n  mutate(TRTPOP = Freq) %&gt;%\n  select(ACTARM, TRTPOP)\n\nanlpop &lt;- as.data.frame(table(anl$ANRIND, anl$ACTARM)) %&gt;%\n  filter(Var1 == \"HIGH\") %&gt;%\n  mutate(ACTARM = as.vector(Var2)) %&gt;%\n  mutate(EVENTCOUNT = Freq) %&gt;%\n  select(ACTARM, EVENTCOUNT)\n\nanl &lt;- left_join(patpop5, anlpop, by = \"ACTARM\")\nCIs &lt;- binom.confint(x = anl$EVENTCOUNT, n = anl$TRTPOP, methods = \"exact\")\nanl &lt;- cbind(anl, CIs[, 4:6])\n\nplot &lt;- ggplot(anl) +\n  geom_bar(aes(x = ACTARM, y = mean * 100), stat = \"identity\", fill = getOption(\"ggplot2.discrete.fill\")[1], alpha = 0.7) +\n  geom_errorbar(aes(x = ACTARM, ymin = lower * 100, ymax = upper * 100),\n    width = 0.5, colour = \"#20b4ff\",\n    alpha = 0.9, linewidth = 1.0\n  ) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percentage\")\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESER == \"Y\")\n\npatpop6 &lt;- dplyr::count(adsl, ACTARM, SEX, name = \"N_arm_sex\")\n\nanl &lt;- anl[!duplicated(anl$USUBJID), ] %&gt;%\n  group_by(ACTARM, SEX) %&gt;%\n  summarise(n = n(), .groups = \"drop\") %&gt;%\n  left_join(patpop6, by = c(\"ACTARM\", \"SEX\")) %&gt;%\n  mutate(pct = round((n / N_arm_sex) * 100, 2))\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]], fill = .data[[\"SEX\"]])) +\n  geom_col(aes(y = pct), position = position_dodge()) +\n  guides(fill = guide_legend(title = getElement(vl_ae, \"SEX\"))) +\n  scale_y_continuous(labels = scales::comma) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percent\")\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae %&gt;%\n  filter(AESER == \"Y\")\n\nanl &lt;- anl[!duplicated(anl$USUBJID), ] %&gt;%\n  group_by(SEX, ACTARM) %&gt;%\n  summarise(n = n(), .groups = \"drop_last\") %&gt;%\n  mutate(N = patpop) %&gt;%\n  mutate(N = as.numeric(N)) %&gt;%\n  mutate(pct = round((n / N) * 100, 2))\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"SEX\"]], fill = .data[[\"ACTARM\"]])) +\n  geom_col(aes(y = pct), position = position_dodge()) +\n  guides(fill = guide_legend(title = getElement(vl_ae, \"ACTARM\"))) +\n  scale_y_continuous(labels = scales::comma) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects With Serious AEs: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"SEX\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percent\")\nplot\n\n\n\n\n\n\n\nCodeanl1 &lt;- adlb %&gt;%\n  filter(AVISIT == \"BASELINE\", PARAMCD == \"CRP\" & ANRIND == \"HIGH\")\n\nanl &lt;- anl1[!duplicated(anl1$USUBJID), ] %&gt;%\n  group_by(ACTARM) %&gt;%\n  summarise(n = n()) %&gt;%\n  mutate(N = patpop) %&gt;%\n  mutate(N = as.numeric(N)) %&gt;%\n  mutate(pct = round((n / N) * 100, 2))\n\ngraph &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]])) +\n  geom_col(aes(x = ACTARM, y = pct), fill = getOption(\"ggplot2.discrete.fill\")[1]) +\n  scale_y_continuous(labels = scales::comma, expand = expansion(c(0, .25))) +\n  geom_text(aes(y = pct, label = pct), stat = \"identity\", vjust = -0.5) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects with Abnormaly High CRP at Baseline \\n Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_lb, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percent\")\n\nsd_w &lt;- anl1 %&gt;%\n  group_by(ACTARM) %&gt;%\n  summarise(\n    mean = round(mean(AVAL, na.rm = TRUE), 2),\n    median = round(median(AVAL, na.rm = TRUE), 2)\n  ) %&gt;%\n  arrange(ACTARM)\n\nsd_l &lt;- gather(sd_w, key = stat, value = value, mean:median)\nsd_l &lt;- sd_l %&gt;% mutate(\n  stat_lbl = case_when(\n    stat == \"mean\" ~ \"Mean\",\n    stat == \"median\" ~ \"Median\"\n  )\n)\n\nsd_l$stat_lbl &lt;- factor(sd_l$stat_lbl, levels = c(\"Median\", \"Mean\"))\n\ntbl_theme &lt;- theme(\n  panel.border = element_blank(),\n  panel.grid.major = element_blank(),\n  panel.grid.minor = element_blank(),\n  axis.ticks = element_blank(),\n  axis.title = element_blank(),\n  axis.text.y = element_text(face = \"plain\"),\n  axis.text.x = element_blank()\n)\n\ntbl &lt;- ggplot(sd_l, aes(x = ACTARM, y = stat_lbl, label = value)) +\n  geom_text(size = 3) +\n  scale_y_discrete(labels = levels(sd_l$stat_lbl)) +\n  theme_bw() +\n  tbl_theme\n\nplot &lt;- ggpubr::ggarrange(graph, tbl,\n  heights = c(4, 1),\n  ncol = 1, nrow = 2, align = \"v\"\n)\nplot\n\n\n\n\n\n\n\nCodeanl &lt;- adae\n\nanl &lt;- anl %&gt;%\n  arrange(USUBJID, AETOXGRC) %&gt;%\n  group_by(USUBJID) %&gt;%\n  slice(n()) %&gt;%\n  ungroup()\n\nanl &lt;- anl[!duplicated(anl$USUBJID), ] %&gt;%\n  group_by(ACTARM, AETOXGRC) %&gt;%\n  summarise(n = n(), .groups = \"drop_last\") %&gt;%\n  mutate(N = patpop) %&gt;%\n  mutate(N = as.numeric(N)) %&gt;%\n  mutate(pct = round((n / N) * 100, 2))\n\nplot &lt;- ggplot(anl, aes(x = .data[[\"ACTARM\"]], fill = .data[[\"AETOXGRC\"]])) +\n  geom_col(aes(y = pct)) +\n  guides(fill = guide_legend(title = getElement(vl_ae, \"AETOXGRC\"))) +\n  scale_y_continuous(labels = scales::comma) +\n  theme(plot.title = element_text(hjust = 0.5)) +\n  ggtitle(\"Percent of Subjects With AE by Highest \\n NCI CTCAE Grade: Safety-Evaluable Subjects\") +\n  xlab(paste0(getElement(vl_ae, \"ACTARM\"), \" (N = \", denom, \")\")) +\n  ylab(\"Percent\")\nplot\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] nestcolor_0.1.2  tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n [5] formatters_0.5.2 tidyr_1.3.0      scda_0.1.6       ggplot2_3.4.3   \n [9] dplyr_1.1.3      binom_1.1-1.1   \n\nloaded via a namespace (and not attached):\n [1] utf8_1.2.3        generics_0.1.3    rstatix_0.7.2     lattice_0.21-8   \n [5] digest_0.6.33     evaluate_0.21     grid_4.3.1        fastmap_1.1.1    \n [9] jsonlite_1.8.7    Matrix_1.6-1.1    backports_1.4.1   brio_1.1.3       \n[13] survival_3.5-7    purrr_1.0.2       fansi_1.0.4       scales_1.2.1     \n[17] codetools_0.2-19  abind_1.4-5       Rdpack_2.5        cli_3.6.1        \n[21] rlang_1.1.1       rbibutils_2.2.15  cowplot_1.1.1     munsell_0.5.0    \n[25] splines_4.3.1     withr_2.5.0       yaml_2.3.7        tools_4.3.1      \n[29] ggsignif_0.6.4    checkmate_2.2.0   colorspace_2.1-0  ggpubr_0.6.0     \n[33] broom_1.0.5       vctrs_0.6.3       R6_2.5.1          lifecycle_1.0.3  \n[37] car_3.1-2         htmlwidgets_1.6.2 pkgconfig_2.0.3   pillar_1.9.0     \n[41] gtable_0.3.4      glue_1.6.2        xfun_0.40         tibble_3.2.1     \n[45] tidyselect_1.2.0  rstudioapi_0.15.0 knitr_1.44        farver_2.1.1     \n[49] htmltools_0.5.6   carData_3.0-5     rmarkdown_2.25    labeling_0.4.3   \n[53] testthat_3.1.10   compiler_4.3.1   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/ippg01.html",
+    "href": "graphs/other/ippg01.html",
+    "title": "IPPG01",
+    "section": "",
+    "text": "For illustration purposes, we will subset the adlb dataset for safety population in treatment arm A and a specific lab parameter (ALT).\n\n\nData Setup\nStandard Plot\nPlot with Patient Baselines as Reference\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\nlibrary(ggplot2)\nlibrary(nestcolor)\n\n# use small sample size\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% slice(1:15)\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;% filter(USUBJID %in% adsl$USUBJID)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadlb &lt;- df_explicit_na(adlb)\n\nadlb_f &lt;- adlb %&gt;%\n  filter(\n    SAFFL == \"Y\",\n    PARAMCD == \"ALT\",\n    AVISIT != \"SCREENING\",\n    ARMCD == \"ARM A\"\n  ) %&gt;%\n  mutate(Patient_ID = sub(\".*id-\", \"\", USUBJID))\n\n\n\n\nThe user can select different plotting_choices depending on their preference. To demonstrate, separate plots are produced with a maximum of 3 observations each.\n\nCodeplots &lt;- g_ipp(\n  df = adlb_f,\n  xvar = \"AVISIT\",\n  yvar = \"AVAL\",\n  xlab = \"Visit\",\n  ylab = \"SGOT/ALT (U/L)\",\n  id_var = \"Patient_ID\",\n  title = \"Individual Patient Plots\",\n  subtitle = \"Treatment Arm A\",\n  plotting_choices = \"split_by_max_obs\",\n  max_obs_per_plot = 3\n)\nplots\n\n[[1]]\n\n\n\n\n\n\n[[2]]\n\n\n\n\n\n\n\nHere, patients’ individual baseline values will be shown for reference. Note that users can provide their own custom theme to the function via the ggtheme argument.\n\nCodeplots &lt;- g_ipp(\n  df = adlb_f,\n  xvar = \"AVISIT\",\n  yvar = \"AVAL\",\n  xlab = \"Visit\",\n  ylab = \"SGOT/ALT (U/L)\",\n  id_var = \"Patient_ID\",\n  title = \"Individual Patient Plots\",\n  subtitle = \"Treatment Arm A\",\n  add_baseline_hline = TRUE,\n  yvar_baseline = \"BASE\",\n  ggtheme = theme_minimal(),\n  plotting_choices = \"split_by_max_obs\",\n  max_obs_per_plot = 3\n)\nplots\n\n[[1]]\n\n\n\n\n\n\n[[2]]\n\n\n\n\n\n\n\n\nCodelibrary(teal)\nlibrary(teal.modules.clinical)\nlibrary(tern)\nlibrary(scda)\n\n# use small sample size\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% slice(1:15)\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;% filter(USUBJID %in% adsl$USUBJID)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb) %&gt;%\n  dplyr::filter(AVISIT != \"SCREENING\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% slice(1:15)\n               ADSL &lt;- df_explicit_na(ADSL)'\n    ),\n    cdisc_dataset(\n      \"ADLB\",\n      adlb,\n      code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;% filter(USUBJID %in% adsl$USUBJID)\n             ADLB &lt;- df_explicit_na(ADLB) %&gt;%\n               dplyr::filter(USUBJID %in% ADSL$USUBJID,\n                             AVISIT != \"SCREENING\")'\n    )\n  ),\n  modules = modules(\n    tm_g_ipp(\n      label = \"Individual Patient Plot\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        value_choices(adlb, c(\"ARMCD\")),\n        \"ARM A\"\n      ),\n      paramcd = choices_selected(\n        value_choices(adlb, \"PARAMCD\"),\n        \"ALT\"\n      ),\n      aval_var = choices_selected(\n        variable_choices(adlb, c(\"AVAL\")),\n        \"AVAL\"\n      ),\n      avalu_var = choices_selected(\n        variable_choices(adlb, c(\"AVALU\")),\n        \"AVALU\",\n        fixed = TRUE\n      ),\n      id_var = choices_selected(\n        variable_choices(adlb, c(\"USUBJID\")),\n        \"USUBJID\",\n        fixed = TRUE\n      ),\n      visit_var = choices_selected(\n        variable_choices(adlb, c(\"AVISIT\")),\n        \"AVISIT\"\n      ),\n      base_var = choices_selected(\n        variable_choices(adlb, c(\"BASE\")),\n        \"BASE\",\n        fixed = TRUE\n      ),\n      add_baseline_hline = FALSE,\n      separate_by_obs = FALSE\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:53:35.9124 pid:6627 token:[] teal.modules.clinical Initializing tm_g_ipp\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] nestcolor_0.1.2              ggplot2_3.4.3               \n [9] dplyr_1.1.3                  scda_0.1.6                  \n[11] tern_0.9.0                   rtables_0.6.3               \n[13] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      farver_2.1.1          fastmap_1.1.1        \n [4] TH.data_1.1-2         promises_1.2.1        shinyjs_2.1.0        \n [7] digest_0.6.33         estimability_1.4.1    mime_0.12            \n[10] tern.gee_0.1.0        lifecycle_1.0.3       ellipsis_0.3.2       \n[13] processx_3.8.2        survival_3.5-7        compiler_4.3.1       \n[16] sass_0.4.7            rlang_1.1.1           tools_4.3.1          \n[19] utf8_1.2.3            yaml_2.3.7            knitr_1.44           \n[22] labeling_0.4.3        htmlwidgets_1.6.2     multcomp_1.4-25      \n[25] withr_2.5.0           purrr_1.0.2           shinyWidgets_0.8.0   \n[28] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[31] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          \n[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       \n[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         \n[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          \n[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       \n[49] jsonlite_1.8.7        callr_3.7.3           teal.widgets_0.4.0   \n[52] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      \n[55] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             \n[58] codetools_0.2-19      gtable_0.3.4          later_1.3.1          \n[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         \n[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      \n[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           \n[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[85] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "graphs/other/ltg01.html",
+    "href": "graphs/other/ltg01.html",
+    "title": "LTG01",
+    "section": "",
+    "text": "Lattice plots are natively handled by R, the examples below rely mostly on the package ggplot2.\n\n\nData Setup\nPlot of Liver Function Tests\nPlot of Liver Function Tests  Including Mean, Median, and 95% CIs\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(teal)\nlibrary(teal.modules.clinical)\nlibrary(ggplot2)\nlibrary(dplyr)\nlibrary(nestcolor)\n\n# Datasets\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% slice(1:8)\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;% filter(USUBJID %in% adsl$USUBJID)\n\n# Pre-processing\nadlb$AVISIT_txt &lt;- adlb$AVISIT\nadlb$AVISIT &lt;- as.numeric(adlb$AVISIT)\nadlb$ARM_N &lt;- adlb$ARM\nlevels(adlb$ARM_N) &lt;- with(\n  data = adlb,\n  paste0(\n    levels(ARM_N), \" (N = \",\n    tapply(SUBJID, ARM_N, function(x) length(unique(x))), \")\"\n  )\n)\n\n# Plot utils\nnpch &lt;- 1:25\nnpatients &lt;- length(unique(adlb$SUBJID))\npch &lt;- c(\n  rep(npch, times = npatients %/% length(npch)),\n  npch[1:(npatients %% length(npch))]\n)\n\n# Add the mean along with the 95% CI at every visit.\nmean_95_text &lt;- \"Mean +/- 95% CI\"\n# Add the median and 95% CI as follows.\nmedian_95_text &lt;- \"Median +/- 95% CI\"\n# Add the median and 95% CI as follows.\nmedian_80_text &lt;- \"Median +/- 80% CI\"\n\n\n\n\nBasic Plot\n\nCode# General mapping and \"lattice\" (\"facet\" in ggplot2 nomenclature).\ng1 &lt;- {\n  ggplot(\n    data = adlb,\n    mapping = aes(x = AVISIT, y = AVAL, colour = SUBJID, shape = SUBJID)\n  ) +\n    facet_grid(LBTESTCD ~ ARM, scales = \"free_y\") +\n    scale_shape_manual(values = pch)\n}\n\n# Add points and lines.\ng1 &lt;- g1 + geom_point()\ng1 &lt;- g1 + geom_line()\nplot &lt;- g1\nplot\n\n\n\n\nModifying Facets\nThe units describing rows of panes and the number of patients under each arm is specified by modifying facet_grid():\n\nCode# Include the units and the sample size N.\ng2 &lt;- g1 + facet_grid(\n  paste0(LBTESTCD, \"\\n(\", AVALU, \")\") ~ ARM_N,\n  scales = \"free_y\"\n)\n\nplot &lt;- g2\nplot\n\n\n\n\nModifying X-Axis\nThe graphic elements are modified through usual ggplot2 functions. For instance, the x-axis could be improved as follows:\n\nCodeg3 &lt;- g2 + theme(\n  axis.text.x = element_text(angle = 45, hjust = 1),\n  axis.title = element_blank()\n) + scale_x_continuous(breaks = adlb$AVISIT, labels = adlb$AVISIT_txt)\n\nplot &lt;- g3\nplot\n\n\n\n\n\n\n\nThe functions stat_mean_ci and stat_median_ci from the tern package allow the addition of mean and/or median confidence intervals. The example below suggests a larger dataset, where the individual subject legend may not be relevant but the mean or the median are of special interest.\nPre-Processing\n\nCode# Datasets\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% slice(1:40)\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;% filter(USUBJID %in% adsl$USUBJID)\n\n# Pre-processing\nadlb$AVISIT_txt &lt;- adlb$AVISIT\nadlb$AVISIT &lt;- as.numeric(adlb$AVISIT)\nadlb$ARM_N &lt;- adlb$ARM\nlevels(adlb$ARM_N) &lt;- with(\n  data = adlb,\n  paste0(\n    levels(ARM_N), \" (N = \",\n    tapply(SUBJID, ARM_N, function(x) length(unique(x))), \")\"\n  )\n)\n\n# Plot utils\nnpch &lt;- 1:25\nnpatients &lt;- length(unique(adlb$SUBJID))\npch &lt;- c(\n  rep(npch, times = npatients %/% length(npch)),\n  npch[1:(npatients %% length(npch))]\n)\n\n\nBasic Plot\n\nCode# General mapping and \"lattice\" (\"facet\" in ggplot2 nomenclature)\ng4 &lt;- {\n  ggplot(\n    data = adlb,\n    mapping = aes(x = AVISIT, y = AVAL, colour = SUBJID, shape = SUBJID)\n  ) +\n    facet_grid(LBTESTCD ~ ARM_N, scales = \"free_y\") +\n    scale_shape_manual(values = pch) +\n    scale_color_manual(values = rep(getOption(\"ggplot2.discrete.colour\"), 2))\n}\n\n# Add points and lines.\n# Note that with so many patients, legend might not be useful and transparency\n#   is advisable.\ng4 &lt;- g4 + geom_point(alpha = .3)\ng4 &lt;- g4 + geom_line(alpha = .3)\ng4 &lt;- g4 + guides(colour = \"none\", shape = \"none\")\ng4 &lt;- g4 + theme(\n  axis.text.x = element_text(angle = 45, hjust = 1),\n  axis.title  = element_blank()\n)\ng4 &lt;- g4 + scale_x_continuous(breaks = adlb$AVISIT, labels = adlb$AVISIT_txt)\nplot &lt;- g4\nplot\n\n\n\n\nAdding Mean\n\nCodeg51 &lt;- g4 + stat_summary(\n  fun = mean, linewidth = 1, geom = \"line\",\n  aes(group = 1, linetype = mean_95_text)\n)\ng51 &lt;- g51 + stat_summary(\n  fun.data = tern::stat_mean_ci, geom = \"errorbar\",\n  aes(group = 1, linetype = mean_95_text)\n)\nplot &lt;- g51\nplot\n\n\n\n\nAdding Median\n\nCode# Instead of a mean, the median could be more relevant.\ng52 &lt;- g51 + stat_summary(\n  fun = median, linewidth = 1, geom = \"line\",\n  aes(group = 1, linetype = median_95_text)\n)\ng52 &lt;- g52 + stat_summary(\n  fun.data = tern::stat_median_ci, geom = \"errorbar\",\n  aes(group = 1, linetype = median_95_text)\n)\nplot &lt;- g52 + guides(linetype = guide_legend(title = \"Aggregate\"))\nplot\n\n\n\n\nChanging Confidence Level\n\nCode# Change the confidence level of interval for the median.\n# Note: check `?stat_mean_ci()` and `?stat_median_ci()` for further fine tuning.\ng53 &lt;- g4 + stat_summary(\n  fun = median, linewidth = 1, geom = \"line\",\n  aes(group = 1, linetype = median_80_text)\n)\ng53 &lt;- g53 + stat_summary(\n  fun.data = function(x) tern::stat_median_ci(x, conf_level = 0.8),\n  geom = \"errorbar\", aes(group = 1, linetype = median_80_text)\n)\nplot &lt;- g53\nplot\n\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] nestcolor_0.1.2              dplyr_1.1.3                 \n [3] ggplot2_3.4.3                teal.modules.clinical_0.8.16\n [5] teal_0.14.0                  teal.transform_0.4.0        \n [7] teal.slice_0.4.0             teal.data_0.3.0             \n [9] shiny_1.7.5                  tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0   farver_2.1.1       fastmap_1.1.1      TH.data_1.1-2     \n [5] promises_1.2.1     shinyjs_2.1.0      digest_0.6.33      estimability_1.4.1\n [9] mime_0.12          tern.gee_0.1.0     lifecycle_1.0.3    ellipsis_0.3.2    \n[13] survival_3.5-7     compiler_4.3.1     rlang_1.1.1        tools_4.3.1       \n[17] utf8_1.2.3         yaml_2.3.7         knitr_1.44         labeling_0.4.3    \n[21] htmlwidgets_1.6.2  multcomp_1.4-25    withr_2.5.0        purrr_1.0.2       \n[25] geepack_1.3.9      grid_4.3.1         fansi_1.0.4        teal.logger_0.1.3 \n[29] xtable_1.8-4       colorspace_2.1-0   emmeans_1.8.8      scales_1.2.1      \n[33] MASS_7.3-60        cli_3.6.1          mvtnorm_1.2-3      rmarkdown_2.25    \n[37] generics_0.1.3     rstudioapi_0.15.0  splines_4.3.1      assertthat_0.2.1  \n[41] vctrs_0.6.3        Matrix_1.6-1.1     sandwich_3.0-2     jsonlite_1.8.7    \n[45] testthat_3.1.10    tidyr_1.3.0        glue_1.6.2         codetools_0.2-19  \n[49] gtable_0.3.4       later_1.3.1        munsell_0.5.0      tibble_3.2.1      \n[53] logger_0.2.2       pillar_1.9.0       htmltools_0.5.6    brio_1.1.3        \n[57] R6_2.5.1           Rdpack_2.5         evaluate_0.21      lattice_0.21-8    \n[61] rbibutils_2.2.15   backports_1.4.1    broom_1.0.5        httpuv_1.6.11     \n[65] Rcpp_1.0.11        coda_0.19-4        nlme_3.1-163       checkmate_2.2.0   \n[69] xfun_0.40          zoo_1.8-12         pkgconfig_2.0.3   \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tlg-index.html",
+    "href": "tlg-index.html",
+    "title": "Index",
+    "section": "",
+    "text": "Tables\n\nADA\n        ADAT01 – Baseline Prevalence and Incidence of Treatment Emergent ADA\n        ADAT02 – Summary of Patients with Treatment-Induced ADA\n        ADAT03 – Summary of Serum Concentrations at Timepoints Where ADA Samples Were Collected and Analyzed\n        ADAT04A – Baseline Prevalence and Incidence of Treatment Emergent NAbs\n        ADAT04B – Baseline Prevalence and Incidence of NAbs\n\n\nAdverse Events\n        AET01 – Safety Summary\n        AET01_AESI – Safety Summary (Adverse Events of Special Interest)\n        AET02 – Adverse Events\n        AET02_SMQ – Adverse Events by Standardized MedDRA Query\n        AET03 – Adverse Events by Greatest Intensity\n        AET04 – Adverse Events by Highest NCI CTCAE Grade\n        AET04_PI – Adverse Events Reported in \\(\\geq\\) 10% of Patients by Highest NCI CTCAE Grade\n        AET05 – Adverse Event Rate Adjusted for Patient-Years at Risk – First Occurrence\n        AET05_ALL – Adverse Event Rate Adjusted for Patient-Years at Risk – All Occurrences\n        AET06 – Adverse Events by Baseline Characteristic\n        AET06_SMQ – Adverse Events by Baseline Characteristic, by SMQ and Preferred Term\n        AET07 – Adverse Events Resulting in Death\n        AET09 – Adverse Events Related to Study Drug\n        AET09_SMQ – Adverse Events Related to Study Drug by Standardized MedDRA Query\n        AET10 – Most Common (\\(\\geq\\) 5%) Adverse Events\n\n\nConcomitant Medications\n        CMT01 – Concomitant Medications (GNEDrug Legacy Coding)\n        CMT01A – Concomitant Medications by Medication Class and Preferred Name\n        CMT01B – Concomitant Medications by Medication Class and Preferred Name\n        CMT02_PT – Concomitant Medications by Preferred Name (WHODrug Coding)\n\n\nDeaths\n        DTHT01 – Deaths\n\n\nDemography\n        DMT01 – Demographics and Baseline Characteristics\n\n\nDisclosures\n        DISCLOSUREST01 – Disclosures Outputs\n        EUDRAT01 – Non-Serious Adverse Events Reported in \\(\\geq\\) 5% of Patients in Any Treatment Group – Patients and Events\n        EUDRAT02 – Serious Adverse Events, Fatal Serious Adverse Events, and Serious Adverse Events Related to Study Medication\n\n\nDisposition\n        DST01 – Patient Disposition\n        PDT01 – Major Protocol Deviations\n        PDT02 – Major Protocol Deviations Related to Epidemic/Pandemic\n\n\nECG\n        EGT01 – ECG Results and Change from Baseline by Visit\n        EGT02 – ECG Abnormalities (EGT02_1 & EGT02_2)\n        EGT03 – Shift Table of ECG Interval Data – Baseline Versus Minimum/Maximum Post-Baseline\n        EGT04 – Shift Table of Qualitative ECG Assessments\n        EGT05_QTCAT – ECG Actual Values and Changes from Baseline by Visit\n\n\nEfficacy\n        AOVT01 – ANCOVA for Multiple End Points\n        AOVT02 – ANCOVA with Single End Point and Customized Table\n        AOVT03 – ANCOVA with Consideration of Interaction\n        CFBT01 – Efficacy Data and Change from Baseline by Visit\n        CMHT01 – Cochran-Mantel-Haenszel (CMH) Summary\n        COXT01 – Cox Regression\n        COXT02 – Multivariable Cox Regression\n        DORT01 – Duration of Response\n        LGRT02 – Multi-Variable Logistic Regression\n        MMRMT01 – Tables for Mixed-Effect Model Repeated Measures Analysis\n        ONCT05 – Objective Response Rate by Subgroup\n        RATET01 – Event Rate Summary for Recurrent Events\n        RBMIT01 – Tables for RBMI\n        RSPT01 – Best Overall Response\n        TTET01 – Time-To-Event Summary\n\n\nExposure\n        EXT01 – Study Drug Exposure Table\n\n\nLab Results\n        LBT01 – Laboratory Test Results and Change from Baseline by Visit\n        LBT02 – Laboratory Test Results by Visit\n        LBT03 – Laboratory Test Results Change from Baseline by Visit\n        LBT04 – Laboratory Abnormalities Not Present at Baseline\n        LBT05 – Laboratory Abnormalities with Single and Replicated Marked\n        LBT06 – Laboratory Abnormalities by Visit and Baseline Status\n        LBT07 – Laboratory Test Results with Highest NCI CTCAE Grade Post-Baseline\n        LBT08 – Laboratory Test Results with Highest NCI CTCAE Grade at Any Time\n        LBT09 – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels\n        LBT10 – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to ULN)\n        LBT10_BL – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to Baseline)\n        LBT11 – Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to ULN)\n        LBT11_BL – Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to Baseline)\n        LBT12 – Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to ULN)\n        LBT12_BL – Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to Baseline)\n        LBT13 – NCI CTCAE Grade Laboratory Abnormalities by Visit and Baseline Grade\n        LBT14 – Laboratory Test Results Shift Table – Highest NCI CTCAE Grade Post-Baseline by Baseline NCI CTCAE Grade\n        LBT15 – Laboratory Test Shifts to NCI CTCAE Grade 3-4 Post-Baseline\n\n\nMedical History\n        MHT01 – Medical History\n\n\nPharmacokinetic\n        PKCT01 – Summary Concentration Table\n        PKPT02 – Pharmacokinetic Parameter Summary – Plasma/Serum/Blood PK Parameters (Stats in Rows)\n        PKPT03 – Pharmacokinetic Parameter Summary of Plasma by Treatment (Stats in Columns)\n        PKPT04 – Pharmacokinetic Parameter Summary – Urine PK Parameters (Stats in Rows)\n        PKPT05 – Summary of Urinary PK Parameters by Treatment Arm (Stats in Columns)\n        PKPT06 – Pharmacokinetic Parameter Summary – Dose-Normalized PK Parameters (Stats in Rows)\n        PKPT07 – Table of Mean Dose-Normalized Selected Pharmacokinetic Parameters (Stats in Columns)\n        PKPT08 – Pharmacokinetic Parameter Summary of Cumulative Amount of Drug Eliminated and Cumulative Percentage of Drug Recovered (Stats in Columns)\n        PKPT11 – Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX\n\n\nRisk Management Plan\n        RMPT01 – Duration of Exposure for Risk Management Plan\n        RMPT03 – Extent of Exposure by Age Group and Gender for Risk Management Plan\n        RMPT04 – Extent of Exposure by Ethnic Origin for Risk Management Plan\n        RMPT05 – Extent of Exposure by Race for Risk Management Plan\n        RMPT06 – Seriousness, Outcomes, Severity, Frequency with 95% CI for Risk Management Plan\n\n\nSafety\n        ENTXX – Enrollment Variants\n\n\nVital Signs\n        VST01 – Vital Sign Results and Change from Baseline by Visit\n        VST02 – Vital Sign Abnormalities\n\n\n\n\nListings\n\nADA\n        ADAL02 – Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients\n\n\nAdverse Events\n        AEL01 – Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms\n        AEL01_NOLLT – Listing of Preferred Terms and Investigator-Specified Adverse Event Terms\n        AEL02 – Listing of Adverse Events\n        AEL02_ED – Listing of Adverse Events (for Early Development Studies)\n        AEL03 – Listing of Serious Adverse Events\n        AEL04 – Listing of Patient Deaths\n\n\nConcomitant Medications\n        CML01 – Listing of Previous and Concomitant Medications\n        CML02A_GL – Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms\n        CML02B_GL – Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms\n\n\nDisposition\n        DSL01 – Listing of Patients with Study Drug Withdrawn Due to Adverse Events\n        DSL02 – Listing of Patients Who Discontinued Early from Study\n\n\nDevelopment Safety Update Report\n        DSUR4 – Listing of Patients Who Died During Reporting Period\n\n\nECG\n        EGL01 – ‘Listing of ECG Data: Safety-Evaluable Patients’\n\n\nExposure\n        EXL01 – Listing of Exposure to Study Drug\n\n\nLab Results\n        LBL01 – Listing of Laboratory Test Results\n        LBL01_RLS – Listing of Laboratory Test Results Using Roche Safety Lab Standardization\n        LBL02A – Listing of Laboratory Abnormalities (constant units)\n        LBL02A_RLS – Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization\n        LBL02B – Listing of Laboratory Abnormalities (variable units)\n\n\nMedical History\n        MHL01 – Listing of Medical History and Concurrent Diseases\n\n\nPharmacokinetic\n        PKCL01 – Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time\n        PKCL02 – Listing of Drug A Urine Concentration and Volumes\n        PKPL01 – Listing of Drug A Plasma PK Parameters\n        PKPL02 – Listing of Drug A Urine PK Parameters\n        PKPL04 – Listing of Individual Drug A AUCIFO and CMAX Ratios Following Drug A or Drug B\n\n\nVital Signs\n        VSL01 – ‘Listing of Vital Signs: Safety-Evaluable Patients’\n\n\n\n\nGraphs\n\nEfficacy\n        FSTG01 – Subgroup Analysis of Best Overall Response\n        FSTG02 – Subgroup Analysis of Survival Duration\n        MMRMG01 – Plots for Mixed-Effect Model Repeated Measures Analysis\n        MMRMG02 – Forest Plot for Mixed-Effect Model Repeated Measures\n\n\nPharmacokinetic\n        PKCG01 – Plot of PK Concentration Over Time by Subject\n        PKCG02 – Plot of PK Concentration Over Time by Cohort/Treatment Group/Dose\n        PKCG03 – Plot of Mean PK Concentration Over Time by Cohort\n        PKPG01 – Plot of Mean Cumulative Percentage (%) of Recovered Drug in Urine\n        PKPG02 – Pharmacokinetic Parameter Summary of Serum PK Parameters by Treatment\n        PKPG03 – Box Plot of Pharmacokinetic Parameters by Visit – Plasma\n        PKPG04 – Box Plot of Pharmacokinetic Parameters by Visit – Plasma\n        PKPG06 – Boxplot of Metabolite to Parent Ratios by Treatment\n\n\nOther\n        BRG01 – Bar Chart\n        BWG01 – Box Plot\n        CIG01 – Confidence Interval Plot\n        IPPG01 – Individual Patient Plot Over Time\n        KMG01 – Kaplan-Meier Plot\n        LTG01 – Lattice Plot of Laboratory Tests by Treatment Group Over Time\n        MNG01 – Mean Plot"
+  },
+  {
+    "objectID": "tables/efficacy/ratet01.html",
+    "href": "tables/efficacy/ratet01.html",
+    "title": "RATET01",
+    "section": "",
+    "text": "This example will focus on data from a single visit “WEEK 1 DAY 8” and a single endpoint “FKSI-FWB”. Only evaluable populations will be analyzed.\n\n\nData Setup\nCustomized Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nanl &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\") %&gt;%\n  filter(PARAMCD == \"TNE\")\n\n# Ensure number of exacerbation is a factor and NAs are explicit missing levels.\nanl$AVAL_f &lt;- as.factor(anl$AVAL)\nanl &lt;- df_explicit_na(anl)\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\", ref_group = \"B: Placebo\") %&gt;%\n  analyze_vars(\n    \"AVAL_f\",\n    var_labels = \"Number of exacerbations per patient\",\n    .stats = c(\"count_fraction\"),\n    .formats = c(\"count_fraction\" = \"xx (xx.xx%)\"),\n    .label = c(\"Number of exacerbations per patient\")\n  ) %&gt;%\n  summarize_glm_count(\n    vars = \"AVAL\",\n    variables = list(arm = \"ARM\", offset = \"lgTMATRSK\", covariates = NULL),\n    conf_level = 0.95,\n    distribution = \"poisson\",\n    rate_mean_method = \"emmeans\",\n    var_labels = \"Unadjusted exacerbation rate (per year)\",\n    table_names = \"unadj\",\n    .stats = c(\"rate\"),\n    .labels = c(rate = \"Rate\")\n  ) %&gt;%\n  summarize_glm_count(\n    vars = \"AVAL\",\n    variables = list(arm = \"ARM\", offset = \"lgTMATRSK\", covariates = c(\"REGION1\")),\n    conf_level = 0.95,\n    distribution = \"quasipoisson\",\n    rate_mean_method = \"ppmeans\",\n    var_labels = \"Adjusted (QP) exacerbation rate (per year)\",\n    table_names = \"adj\",\n    .stats = c(\"rate\", \"rate_ci\", \"rate_ratio\", \"rate_ratio_ci\", \"pval\"),\n    .labels = c(\n      rate = \"Rate\", rate_ci = \"Rate CI\", rate_ratio = \"Rate Ratio\",\n      rate_ratio_ci = \"Rate Ratio CI\", pval = \"p value\"\n    )\n  )\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = anl\n)\n\nresult\n\n                                                B: Placebo         A: Drug X        C: Combination \n                                                 (N=134)            (N=134)            (N=132)     \n———————————————————————————————————————————————————————————————————————————————————————————————————\nNumber of exacerbations per patient                                                                \n  0                                             10 (7.46%)         6 (4.48%)          11 (8.33%)   \n  1                                            25 (18.66%)        21 (15.67%)        14 (10.61%)   \n  2                                            38 (28.36%)        41 (30.60%)        33 (25.00%)   \n  3                                            22 (16.42%)        26 (19.40%)        21 (15.91%)   \n  4                                             13 (9.70%)        18 (13.43%)        30 (22.73%)   \n  5                                             11 (8.21%)         10 (7.46%)         12 (9.09%)   \n  6                                             10 (7.46%)         7 (5.22%)          7 (5.30%)    \n  7                                             3 (2.24%)          4 (2.99%)          3 (2.27%)    \n  8                                             1 (0.75%)          1 (0.75%)          1 (0.76%)    \n  9                                             1 (0.75%)          0 (0.00%)          0 (0.00%)    \nUnadjusted exacerbation rate (per year)                                                            \n  Rate                                            7.2364             8.2148             9.8131     \nAdjusted (QP) exacerbation rate (per year)                                                         \n  Rate                                            2.4550             2.8514             3.4304     \n  Rate CI                                    (1.6194, 3.7219)   (1.8974, 4.2850)   (2.2946, 5.1284)\n  Rate Ratio                                                         1.1615             1.3973     \n  Rate Ratio CI                                                 (0.6462, 2.0877)   (0.7789, 2.5067)\n  p value                                                            0.6169             0.2619     \n\n\n\n\n\nCode# In Progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] sandwich_3.0-2     utf8_1.2.3         generics_0.1.3     tidyr_1.3.0       \n [5] lattice_0.21-8     digest_0.6.33      evaluate_0.21      grid_4.3.1        \n [9] estimability_1.4.1 mvtnorm_1.2-3      fastmap_1.1.1      jsonlite_1.8.7    \n[13] Matrix_1.6-1.1     backports_1.4.1    brio_1.1.3         survival_3.5-7    \n[17] multcomp_1.4-25    purrr_1.0.2        fansi_1.0.4        scales_1.2.1      \n[21] TH.data_1.1-2      codetools_0.2-19   Rdpack_2.5         cli_3.6.1         \n[25] rlang_1.1.1        rbibutils_2.2.15   munsell_0.5.0      splines_4.3.1     \n[29] yaml_2.3.7         tools_4.3.1        checkmate_2.2.0    coda_0.19-4       \n[33] colorspace_2.1-0   ggplot2_3.4.3      forcats_1.0.0      broom_1.0.5       \n[37] vctrs_0.6.3        R6_2.5.1           zoo_1.8-12         lifecycle_1.0.3   \n[41] emmeans_1.8.8      htmlwidgets_1.6.2  MASS_7.3-60        pkgconfig_2.0.3   \n[45] pillar_1.9.0       gtable_0.3.4       glue_1.6.2         xfun_0.40         \n[49] tibble_3.2.1       tidyselect_1.2.0   rstudioapi_0.15.0  knitr_1.44        \n[53] xtable_1.8-4       htmltools_0.5.6    rmarkdown_2.25     testthat_3.1.10   \n[57] compiler_4.3.1    \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/mmrmt01.html",
+    "href": "tables/efficacy/mmrmt01.html",
+    "title": "MMRMT01",
+    "section": "",
+    "text": "Data Setup\nLeast Squares Means\nFixed Effects\nCovariance Matrix\nModel Diagnostics\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern.mmrm)\nlibrary(scda)\nlibrary(broom)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\nadqs_f &lt;- adqs %&gt;%\n  dplyr::filter(PARAMCD == \"FKSI-FWB\" & !AVISIT %in% c(\"BASELINE\", \"SCREENING\")) %&gt;%\n  droplevels() %&gt;%\n  dplyr::mutate(ARMCD = factor(ARMCD, levels = c(\"ARM B\", \"ARM A\", \"ARM C\"))) %&gt;%\n  dplyr::mutate(\n    AVISITN = rank(AVISITN) %&gt;%\n      as.factor() %&gt;%\n      as.numeric() %&gt;%\n      as.factor()\n  )\nadsl_sub &lt;- adqs_f %&gt;%\n  dplyr::filter(!is.na(CHG)) %&gt;%\n  distinct(USUBJID) %&gt;%\n  left_join(adsl, by = \"USUBJID\")\nvar_labels(adqs_f) &lt;- var_labels(adqs)\n\n\n\n\nConsidering the treatment variable in the model\n\nCodemmrm_results &lt;- fit_mmrm(\n  vars = list(\n    response = \"CHG\",\n    covariates = c(\"BASE\", \"STRATA1\", \"BMRKR2\"),\n    id = \"USUBJID\",\n    arm = \"ARMCD\",\n    visit = \"AVISIT\"\n  ),\n  data = adqs_f,\n  weights_emmeans = \"equal\"\n)\n\nWarning: \"automatic\" optimizer was deprecated in mmrm 0.2.0.\nℹ please just omit optimizer argument\nℹ The deprecated feature was likely used in the mmrm package.\n  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.\n\nCodedf &lt;- tidy(mmrm_results)\nattr(df$AVISIT, \"label\") &lt;- \"Visit\"\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = mmrm_results$ref_level) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(df$AVISIT)) %&gt;%\n  summarize_lsmeans(show_relative = \"increase\") %&gt;%\n  append_topleft(\"  Statistics\") %&gt;%\n  build_table(df, alt_counts_df = adsl_sub)\n\nresult\n\nVisit                                      ARM B              ARM A              ARM C      \n  Statistics                              (N=134)            (N=134)            (N=132)     \n————————————————————————————————————————————————————————————————————————————————————————————\nWEEK 1 DAY 8                                                                                \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  \n    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) \n  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) \n    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) \n    Relative Increase (%)                                     21.8%              -9.3%      \n    p-value (MMRM)                                            0.4362             0.7393     \nWEEK 2 DAY 15                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  \n    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) \n  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) \n    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) \n    Relative Increase (%)                                     -1.3%              -6.8%      \n    p-value (MMRM)                                            0.9147             0.5662     \nWEEK 3 DAY 22                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) \n    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)\n  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  \n    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) \n    Relative Increase (%)                                     18.2%              16.6%      \n    p-value (MMRM)                                            0.0460             0.0704     \nWEEK 4 DAY 29                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) \n    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)\n  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  \n    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) \n    Relative Increase (%)                                      7.6%               7.8%      \n    p-value (MMRM)                                            0.3288             0.3192     \nWEEK 5 DAY 36                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) \n    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)\n  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  \n    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) \n    Relative Increase (%)                                      6.1%               0.9%      \n    p-value (MMRM)                                            0.3408             0.8937     \n\n\nNot considering the treatment variable in the model\n\nCodemmrm_results_no_arm &lt;- fit_mmrm(\n  vars = list(\n    response = \"CHG\",\n    covariates = c(\"BMRKR2\", \"STRATA1\"),\n    id = \"USUBJID\",\n    visit = \"AVISIT\"\n  ),\n  data = adqs_f,\n  weights_emmeans = \"equal\",\n  parallel = TRUE\n)\n\nWarning: `free_cores()` was deprecated in mmrm 0.1.6.\nℹ Please use the `omit` argument of `parallelly::availableCores()` instead.\nℹ The deprecated feature was likely used in the tern.mmrm package.\n  Please report the issue at\n  &lt;https://github.com/insightsengineering/tern.mmrm/issues&gt;.\n\nCodedf_no_arm &lt;- tidy(mmrm_results_no_arm)\nattr(df_no_arm$AVISIT, \"label\") &lt;- \"Visit\"\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(df_no_arm$AVISIT)) %&gt;%\n  summarize_lsmeans(arms = FALSE) %&gt;%\n  append_topleft(\"  Statistics\") %&gt;%\n  build_table(df_no_arm, alt_counts_df = adsl_sub)\n\nresult\n\nVisit                    All Patients  \n  Statistics               (N=400)     \n———————————————————————————————————————\nWEEK 1 DAY 8                           \n  n                          400       \n  Adjusted Mean (SE)    3.615 (0.620)  \n    95% CI              (2.396, 4.834) \nWEEK 2 DAY 15                          \n  n                          400       \n  Adjusted Mean (SE)    8.870 (0.602)  \n    95% CI             (7.687, 10.053) \nWEEK 3 DAY 22                          \n  n                          400       \n  Adjusted Mean (SE)    15.094 (0.683) \n    95% CI             (13.751, 16.437)\nWEEK 4 DAY 29                          \n  n                          400       \n  Adjusted Mean (SE)    19.009 (0.717) \n    95% CI             (17.599, 20.418)\nWEEK 5 DAY 36                          \n  n                          400       \n  Adjusted Mean (SE)    24.028 (0.747) \n    95% CI             (22.560, 25.496)\n\n\nAdding baseline rows\nIt may be of interest to summarize some different statistics at the baseline visit or summarize a different variable in the data set not used in the MMRM. For example, the model may use the variable CHG but the baseline visit row may summarize the AVAL variable, thus we would need to create two tables and then combine them to accomplish this.\n\nCode# First have the least-square means table.\na &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = mmrm_results$ref_level) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(df$AVISIT)) %&gt;%\n  summarize_lsmeans(show_relative = \"increase\") %&gt;%\n  append_topleft(\"  Statistics\") %&gt;%\n  build_table(df, alt_counts_df = adsl_sub)\n\n# Second prepare the baseline values summary table.\nbaseline_dat &lt;- adqs %&gt;%\n  filter(AVISIT == \"BASELINE\") %&gt;%\n  droplevels()\n\nb &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\") %&gt;%\n  split_rows_by(\"AVISIT\") %&gt;%\n  analyze_vars(\"AVAL\") %&gt;%\n  append_topleft(\"  Statistics\") %&gt;%\n  build_table(baseline_dat, alt_counts_df = adsl_sub)\n\n# Now we can combine them as follows.\ncol_info(b) &lt;- EmptyColInfo\nrbind(b, a)\n\nVisit                                      ARM B              ARM A              ARM C      \n  Statistics                              (N=134)            (N=134)            (N=132)     \n————————————————————————————————————————————————————————————————————————————————————————————\nBASELINE                                                                                    \n  n                                         670                670                660       \n  Mean (SD)                              49.8 (8.1)         50.4 (8.3)         50.2 (8.4)   \n  Median                                    49.6               50.2               50.4      \n  Min - Max                             24.3 - 72.9        21.7 - 74.5        26.0 - 71.4   \nWEEK 1 DAY 8                                                                                \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  \n    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) \n  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) \n    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) \n    Relative Increase (%)                                     21.8%              -9.3%      \n    p-value (MMRM)                                            0.4362             0.7393     \nWEEK 2 DAY 15                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  \n    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) \n  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) \n    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) \n    Relative Increase (%)                                     -1.3%              -6.8%      \n    p-value (MMRM)                                            0.9147             0.5662     \nWEEK 3 DAY 22                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) \n    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)\n  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  \n    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) \n    Relative Increase (%)                                     18.2%              16.6%      \n    p-value (MMRM)                                            0.0460             0.0704     \nWEEK 4 DAY 29                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) \n    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)\n  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  \n    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) \n    Relative Increase (%)                                      7.6%               7.8%      \n    p-value (MMRM)                                            0.3288             0.3192     \nWEEK 5 DAY 36                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) \n    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)\n  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  \n    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) \n    Relative Increase (%)                                      6.1%               0.9%      \n    p-value (MMRM)                                            0.3408             0.8937     \n\n\nConsidering visit averages\nIt may also be of interest to summarize several different statistics for an averaged combination of various visits in the MMRM. For example, you may want to see the statistics for the average of the first 2 visits, or the average statistics of all visits combined. This can be accomplished by specifying the averages_emmeans argument when fitting the MMRM model.\n\nCodemmrm_results_avg_visits &lt;- fit_mmrm(\n  vars = list(\n    response = \"CHG\",\n    covariates = c(\"BASE\", \"STRATA1\", \"BMRKR2\"),\n    id = \"USUBJID\",\n    arm = \"ARMCD\",\n    visit = \"AVISIT\"\n  ),\n  data = adqs_f,\n  weights_emmeans = \"equal\",\n  averages_emmeans = list(\n    \"WEEKS 1-2\" = c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\"),\n    \"WEEKS 3-5\" = c(\"WEEK 3 DAY 22\", \"WEEK 4 DAY 29\", \"WEEK 5 DAY 36\"),\n    \"ALL VISITS\" = c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\", \"WEEK 4 DAY 29\", \"WEEK 5 DAY 36\")\n  )\n)\n\ndf_avgs &lt;- tidy(mmrm_results_avg_visits)\nattr(df_avgs$AVISIT, \"label\") &lt;- \"Visit\"\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = mmrm_results_avg_visits$ref_level) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(df_avgs$AVISIT)) %&gt;%\n  summarize_lsmeans(show_relative = \"increase\") %&gt;%\n  append_topleft(\"  Statistics\") %&gt;%\n  build_table(df_avgs, alt_counts_df = adsl_sub)\n\nresult\n\nVisit                                      ARM B              ARM A              ARM C      \n  Statistics                              (N=134)            (N=134)            (N=132)     \n————————————————————————————————————————————————————————————————————————————————————————————\nWEEK 1 DAY 8                                                                                \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  \n    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) \n  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) \n    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) \n    Relative Increase (%)                                     21.8%              -9.3%      \n    p-value (MMRM)                                            0.4362             0.7393     \nWEEK 2 DAY 15                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  \n    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) \n  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) \n    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) \n    Relative Increase (%)                                     -1.3%              -6.8%      \n    p-value (MMRM)                                            0.9147             0.5662     \nWEEK 3 DAY 22                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) \n    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)\n  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  \n    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) \n    Relative Increase (%)                                     18.2%              16.6%      \n    p-value (MMRM)                                            0.0460             0.0704     \nWEEK 4 DAY 29                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) \n    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)\n  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  \n    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) \n    Relative Increase (%)                                      7.6%               7.8%      \n    p-value (MMRM)                                            0.3288             0.3192     \nWEEK 5 DAY 36                                                                               \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) \n    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)\n  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  \n    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) \n    Relative Increase (%)                                      6.1%               0.9%      \n    p-value (MMRM)                                            0.3408             0.8937     \nWEEKS 1-2                                                                                   \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   6.311 (0.514)      6.632 (0.514)      5.836 (0.516)  \n    95% CI                             (5.301, 7.322)     (5.623, 7.642)     (4.821, 6.852) \n  Difference in Adjusted Means (SE)                       0.321 (0.728)      -0.475 (0.729) \n    95% CI                                               (-1.111, 1.753)    (-1.909, 0.959) \n    Relative Increase (%)                                      5.1%              -7.5%      \n    p-value (MMRM)                                            0.6596             0.5151     \nWEEKS 3-5                                                                                   \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   18.384 (0.560)     20.141 (0.560)     19.668 (0.563) \n    95% CI                            (17.284, 19.485)   (19.041, 21.241)   (18.562, 20.775)\n  Difference in Adjusted Means (SE)                       1.757 (0.793)      1.284 (0.794)  \n    95% CI                                                (0.198, 3.316)    (-0.278, 2.846) \n    Relative Increase (%)                                      9.6%               7.0%      \n    p-value (MMRM)                                            0.0273             0.1068     \nALL VISITS                                                                                  \n  n                                         134                134                132       \n  Adjusted Mean (SE)                   13.555 (0.388)     14.738 (0.388)     14.135 (0.389) \n    95% CI                            (12.792, 14.318)   (13.976, 15.500)   (13.370, 14.900)\n  Difference in Adjusted Means (SE)                       1.183 (0.551)      0.580 (0.551)  \n    95% CI                                                (0.100, 2.266)    (-0.502, 1.663) \n    Relative Increase (%)                                      8.7%               4.3%      \n    p-value (MMRM)                                            0.0324             0.2924     \n\n\n\n\n\nConsidering the treatment variable in the model\n\nCodeas.rtable(mmrm_results, type = \"fixed\")\n\n                                 Estimate   Std. Error   t value    df    Pr(&gt;|t|)\n——————————————————————————————————————————————————————————————————————————————————\n(Intercept)                      55.7483      1.5244     36.5713    510   &lt;0.0001 \nBASE                             -1.0196      0.0246     -41.4362   392   &lt;0.0001 \nSTRATA1B                         -0.0369      0.5345     -0.0691    392    0.9450 \nSTRATA1C                          0.0205      0.5238      0.0392    392    0.9688 \nBMRKR2MEDIUM                     -0.3840      0.5198     -0.7386    392    0.4606 \nBMRKR2HIGH                       -1.0056      0.5259     -1.9123    392    0.0566 \nARMCDARM A                        0.7587      0.9733      0.7795    396    0.4362 \nARMCDARM C                       -0.3248      0.9756     -0.3329    394    0.7393 \nAVISITWEEK 2 DAY 15               5.6472      1.0331      5.4665    397   &lt;0.0001 \nAVISITWEEK 3 DAY 22              10.0591      1.0897      9.2311    397   &lt;0.0001 \nAVISITWEEK 4 DAY 29              14.6145      1.2176     12.0027    397   &lt;0.0001 \nAVISITWEEK 5 DAY 36              20.0154      1.2584     15.9057    397   &lt;0.0001 \nARMCDARM A:AVISITWEEK 2 DAY 15   -0.8752      1.4610     -0.5990    397    0.5495 \nARMCDARM C:AVISITWEEK 2 DAY 15   -0.3007      1.4665     -0.2050    397    0.8376 \nARMCDARM A:AVISITWEEK 3 DAY 22    1.7085      1.5411      1.1087    397    0.2682 \nARMCDARM C:AVISITWEEK 3 DAY 22    2.5673      1.5469      1.6597    397    0.0978 \nARMCDARM A:AVISITWEEK 4 DAY 29    0.6181      1.7220      0.3589    397    0.7198 \nARMCDARM C:AVISITWEEK 4 DAY 29    1.7337      1.7285      1.0030    397    0.3165 \nARMCDARM A:AVISITWEEK 5 DAY 36    0.6690      1.7796      0.3759    397    0.7072 \nARMCDARM C:AVISITWEEK 5 DAY 36    0.5257      1.7863      0.2943    397    0.7687 \n\n\nNot considering the treatment variable in the model\n\nCodeas.rtable(mmrm_results_no_arm, type = \"fixed\")\n\n                      Estimate   Std. Error   t value   df    Pr(&gt;|t|)\n——————————————————————————————————————————————————————————————————————\n(Intercept)            1.5624      1.1751     1.3296    466    0.1843 \nBMRKR2MEDIUM           1.0924      1.1878     0.9196    395    0.3583 \nBMRKR2HIGH             1.4619      1.1971     1.2212    395    0.2227 \nSTRATA1B               2.6321      1.2180     2.1610    395    0.0313 \nSTRATA1C               0.9717      1.2008     0.8092    395    0.4189 \nAVISITWEEK 2 DAY 15    5.2548      0.5967     8.8061    399   &lt;0.0001 \nAVISITWEEK 3 DAY 22   11.4787      0.6314     18.1802   399   &lt;0.0001 \nAVISITWEEK 4 DAY 29   15.3937      0.7039     21.8696   399   &lt;0.0001 \nAVISITWEEK 5 DAY 36   20.4130      0.7266     28.0921   399   &lt;0.0001 \n\n\n\n\n\n\nCodeas.rtable(mmrm_results, type = \"cov\")\n\n                WEEK 1 DAY 8   WEEK 2 DAY 15   WEEK 3 DAY 22   WEEK 4 DAY 29   WEEK 5 DAY 36\n————————————————————————————————————————————————————————————————————————————————————————————\nWEEK 1 DAY 8      63.0140         -0.6664         2.5965          -1.6231         0.2589    \nWEEK 2 DAY 15     -0.6664         78.6592         1.7004         -11.8677         -0.4261   \nWEEK 3 DAY 22      2.5965         1.7004         101.2949         -5.8424         7.1145    \nWEEK 4 DAY 29     -1.6231        -11.8677         -5.8424        132.4034         -5.3739   \nWEEK 5 DAY 36      0.2589         -0.4261         7.1145          -5.3739        149.6937   \n\n\n\n\nModel diagnostics are currently available to evaluate choice of covariates for the fixed and random effects. Statistics to evaluate choice of covariance structure are being investigated and will be included in a future release.\n\nCodeas.rtable(mmrm_results, type = \"diagnostic\")\n\n                 Diagnostic statistic value\n———————————————————————————————————————————\nREML criterion           14835.9968        \nAIC                      14865.9968        \nAICc                     14866.2412        \nBIC                      14925.8688        \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\") %&gt;%\n  dplyr::filter(ABLFL != \"Y\" & ABLFL2 != \"Y\") %&gt;%\n  dplyr::filter(AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\")) %&gt;%\n  dplyr::mutate(\n    AVISIT = as.factor(AVISIT),\n    AVISITN = rank(AVISITN) %&gt;%\n      as.factor() %&gt;%\n      as.numeric() %&gt;%\n      as.factor() # making consecutive numeric factor\n  )\n\narm_ref_comp &lt;- list(\n  ARMCD = list(\n    ref = \"ARM A\",\n    comp = c(\"ARM B\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADQS\", adqs,\n      code = 'ADQS &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\") %&gt;%\n              dplyr::filter(ABLFL != \"Y\" & ABLFL2 != \"Y\") %&gt;%\n              dplyr::filter(AVISIT %in% c(\"WEEK 1 DAY 8\", \"WEEK 2 DAY 15\", \"WEEK 3 DAY 22\")) %&gt;%\n              dplyr::mutate(\n                AVISIT = as.factor(AVISIT),\n                AVISITN = rank(AVISITN) %&gt;%\n                  as.factor() %&gt;%\n                  as.numeric() %&gt;%\n                  as.factor() # making consecutive numeric factor\n              )'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_a_mmrm(\n      label = \"MMRM\",\n      dataname = \"ADQS\",\n      aval_var = choices_selected(c(\"AVAL\", \"CHG\"), \"CHG\"),\n      id_var = choices_selected(c(\"USUBJID\", \"SUBJID\"), \"USUBJID\"),\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARMCD\"),\n      visit_var = choices_selected(c(\"AVISIT\", \"AVISITN\"), \"AVISIT\"),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        choices = value_choices(adqs, \"PARAMCD\", \"PARAM\"),\n        selected = \"FKSI-FWB\"\n      ),\n      cov_var = choices_selected(c(\"BASE\", \"AGE\", \"SEX\", \"BASE:AVISIT\"), NULL),\n      conf_level = choices_selected(c(0.95, 0.9, 0.8), 0.95)\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:57:17.7265 pid:7260 token:[] teal.modules.clinical Initializing tm_a_mmrm\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] broom_1.0.5                  scda_0.1.6                  \n [9] tern.mmrm_0.2.1              tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] Rdpack_2.5            mmrm_0.2.2            tern.gee_0.1.0       \n [4] logger_0.2.2          testthat_3.1.10       sandwich_3.0-2       \n [7] rlang_1.1.1           multcomp_1.4-25       compiler_4.3.1       \n[10] callr_3.7.3           vctrs_0.6.3           stringr_1.5.0        \n[13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      \n[16] ellipsis_0.3.2        fontawesome_0.5.2     utf8_1.2.3           \n[19] promises_1.2.1        rmarkdown_2.25        ps_1.7.5             \n[22] purrr_1.0.2           xfun_0.40             cachem_1.0.8         \n[25] teal.reporter_0.2.1   jsonlite_1.8.7        later_1.3.1          \n[28] parallel_4.3.1        R6_2.5.1              bslib_0.5.1          \n[31] stringi_1.7.12        brio_1.1.3            jquerylib_0.1.4      \n[34] numDeriv_2016.8-1.1   estimability_1.4.1    Rcpp_1.0.11          \n[37] assertthat_0.2.1      knitr_1.44            zoo_1.8-12           \n[40] teal.logger_0.1.3     httpuv_1.6.11         Matrix_1.6-1.1       \n[43] splines_4.3.1         tidyselect_1.2.0      rstudioapi_0.15.0    \n[46] yaml_2.3.7            TMB_1.9.6             codetools_0.2-19     \n[49] processx_3.8.2        teal.widgets_0.4.0    lattice_0.21-8       \n[52] tibble_3.2.1          withr_2.5.0           coda_0.19-4          \n[55] evaluate_0.21         survival_3.5-7        pillar_1.9.0         \n[58] shinycssloaders_1.0.0 checkmate_2.2.0       shinyjs_2.1.0        \n[61] generics_0.1.3        ggplot2_3.4.3         munsell_0.5.0        \n[64] scales_1.2.1          xtable_1.8-4          glue_1.6.2           \n[67] emmeans_1.8.8         tools_4.3.1           webshot_0.5.5        \n[70] forcats_1.0.0         mvtnorm_1.2-3         cowplot_1.1.1        \n[73] grid_4.3.1            tidyr_1.3.0           rbibutils_2.2.15     \n[76] colorspace_2.1-0      nlme_3.1-163          cli_3.6.1            \n[79] fansi_1.0.4           geepack_1.3.9         gtable_0.3.4         \n[82] sass_0.4.7            digest_0.6.33         TH.data_1.1-2        \n[85] htmlwidgets_1.6.2     memoise_2.0.1         htmltools_0.5.6      \n[88] lifecycle_1.0.3       shinyWidgets_0.8.0    mime_0.12            \n[91] MASS_7.3-60          \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/onct05.html",
+    "href": "tables/efficacy/onct05.html",
+    "title": "ONCT05",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Specifying  Class Variables\nTable Selecting Columns  and Changing the Alpha Level\nTable Setting Values  Indicating Response\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadrs &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadrs &lt;- df_explicit_na(adrs)\n\nadsl &lt;- adsl %&gt;%\n  select(STUDYID, USUBJID, ARM, SEX, RACE, STRATA1, STRATA2)\n\nadrs &lt;- adrs %&gt;%\n  filter(PARAMCD == \"INVET\") %&gt;%\n  select(STUDYID, USUBJID, PARAMCD, AVALC)\n\nanl &lt;- inner_join(adsl, adrs, by = c(\"STUDYID\", \"USUBJID\"))\nanl_labels &lt;- var_labels(anl)\n\nanl &lt;- anl %&gt;%\n  filter(ARM %in% c(\"A: Drug X\", \"B: Placebo\")) %&gt;%\n  mutate(\n    # Reorder levels of factor to make the placebo group the reference arm.\n    ARM = relevel(ARM, ref = \"B: Placebo\") %&gt;%\n      droplevels()\n  ) %&gt;%\n  droplevels() %&gt;%\n  mutate(rsp = AVALC %in% c(\"CR\", \"PR\"))\n\nvar_labels(anl) &lt;- c(anl_labels, rsp = \"Is Response\")\n\n\n\n\n\nCodedf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"STRATA2\")\n  ),\n  data = anl\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\nresult\n\nBaseline Risk Factors                         B: Placebo                         A: Drug X                                       \n                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.04, 2.95)\nSex                                                                                                                              \n  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.21, 4.76)\n  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.47, 2.48)\nStratification Factor 2                                                                                                          \n  S1                        140     67        38          56.7%       73        56          76.7%          2.51      (1.22, 5.20)\n  S2                        128     67        46          68.7%       61        44          72.1%          1.18      (0.55, 2.53)\n\n\n\n\nHere, the levels of subgroup variables SEX and STRATA1 are reordered. STRATA1 is reordered by frequency.\n\nCodeanl_reorder &lt;- anl %&gt;%\n  mutate(\n    SEX = forcats::fct_relevel(SEX, \"M\", \"F\"),\n    STRATA1 = forcats::fct_infreq(STRATA1)\n  )\n\ndf &lt;- extract_rsp_subgroups(\n  variables = list(rsp = \"rsp\", arm = \"ARM\", subgroups = c(\"SEX\", \"STRATA1\")),\n  data = anl_reorder\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\nresult\n\nBaseline Risk Factors                         B: Placebo                         A: Drug X                                       \n                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.04, 2.95)\nSex                                                                                                                              \n  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.47, 2.48)\n  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.21, 4.76)\nStratification Factor 1                                                                                                          \n  C                         94      45        33          73.3%       49        37          75.5%          1.12      (0.44, 2.83)\n  B                         92      45        26          57.8%       47        32          68.1%          1.56      (0.66, 3.66)\n  A                         82      44        25          56.8%       38        31          81.6%          3.37      (1.22, 9.28)\n\n\n\n\n\nCodedf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"STRATA2\")\n  ),\n  data = anl,\n  conf_level = 0.9,\n  method = \"chisq\"\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\", \"pval\"))\n\nresult\n\nBaseline Risk Factors                         B: Placebo                         A: Drug X                                                                    \n                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      90% CI      p-value (Chi-Squared Test)\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.13, 2.72)             0.0351          \nSex                                                                                                                                                           \n  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.35, 4.27)             0.0113          \n  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.54, 2.17)             0.8497          \nStratification Factor 2                                                                                                                                       \n  S1                        140     67        38          56.7%       73        56          76.7%          2.51      (1.37, 4.63)             0.0119          \n  S2                        128     67        46          68.7%       61        44          72.1%          1.18      (0.62, 2.24)             0.6674          \n\n\n\n\nCreate a new variable new_rsp in anl data that uses new criteria for responder.\n\nCodeanl_new &lt;- anl %&gt;%\n  mutate(new_rsp = AVALC == \"CR\")\n\ndf &lt;- extract_rsp_subgroups(\n  variables = list(\n    rsp = \"new_rsp\",\n    arm = \"ARM\",\n    subgroups = c(\"SEX\", \"STRATA2\")\n  ),\n  data = anl_new\n)\n\nresult &lt;- basic_table() %&gt;%\n  tabulate_rsp_subgroups(df, vars = c(\"n_tot\", \"n\", \"n_rsp\", \"prop\", \"or\", \"ci\"))\n\nresult\n\nBaseline Risk Factors                         B: Placebo                         A: Drug X                                       \n                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAll Patients                268     134       47          35.1%       134       60          44.8%          1.50      (0.92, 2.45)\nSex                                                                                                                              \n  F                         161     82        25          30.5%       79        39          49.4%          2.22      (1.17, 4.24)\n  M                         107     52        22          42.3%       55        21          38.2%          0.84      (0.39, 1.83)\nStratification Factor 2                                                                                                          \n  S1                        140     67        21          31.3%       73        31          42.5%          1.62      (0.81, 3.24)\n  S2                        128     67        26          38.8%       61        29          47.5%          1.43      (0.71, 2.89)\n\n\n\n\n\nCode# Use table, embedded in response forest plot module.\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\nlibrary(forcats)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadrs &lt;- synthetic_cdisc_dataset(\"latest\", \"adrs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadrs &lt;- df_explicit_na(adrs)\n\narm_ref_comp &lt;- list(\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  ),\n  ARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADRS\", adrs, code = 'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adrs\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_g_forest_rsp(\n      label = \"Forest Response\",\n      dataname = \"ADRS\",\n      arm_var = choices_selected(\n        variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        \"ARMCD\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adrs, \"PARAMCD\", \"PARAM\"),\n        \"BESRSPI\"\n      ),\n      subgroup_var = choices_selected(\n        variable_choices(adsl, names(adsl)),\n        c(\"SEX\")\n      ),\n      strata_var = choices_selected(\n        variable_choices(adsl, c(\"STRATA1\", \"STRATA2\")),\n        \"STRATA2\"\n      ),\n      plot_height = c(600L, 200L, 2000L)\n    )\n  )\n)\n\n[INFO] 2023-09-25 10:58:54.4195 pid:7461 token:[] teal.modules.clinical Initializing tm_g_forest_rsp\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] forcats_1.0.0                teal.modules.clinical_0.8.16\n [3] teal_0.14.0                  teal.transform_0.4.0        \n [5] teal.slice_0.4.0             teal.data_0.3.0             \n [7] shiny_1.7.5                  scda_0.1.6                  \n [9] dplyr_1.1.3                  tern_0.9.0                  \n[11] rtables_0.6.3                magrittr_2.0.3              \n[13] formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/aovt02.html",
+    "href": "tables/efficacy/aovt02.html",
+    "title": "AOVT02",
+    "section": "",
+    "text": "This example will focus on data from a single visit “WEEK 1 DAY 8” and a single endpoint “FKSI-FWB”. Only evaluable populations will be analyzed.\n\n\nData Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\nadqs_single &lt;- adqs %&gt;%\n  filter(\n    AVISIT == \"WEEK 1 DAY 8\",\n    PARAMCD == \"FKSI-FWB\"\n  ) %&gt;%\n  mutate(CHG = ifelse(BMEASIFL == \"Y\", CHG, NA))\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  append_varlabels(adqs_single, \"PARAM\") %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(arm = \"ARMCD\", covariates = NULL),\n    conf_level = 0.95,\n    var_labels = \"Unadjusted comparison\",\n    .labels = c(lsmean = \"Mean\", lsmean_diff = \"Difference in Means\"),\n    table_names = \"unadjusted\"\n  ) %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(arm = \"ARMCD\", covariates = c(\"BASE\", \"STRATA1\")),\n    conf_level = 0.95,\n    var_labels = \"Adjusted comparison (covariates BASE and STRATA1)\",\n    table_names = \"adjusted\"\n  )\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adqs_single,\n  alt_counts_df = adsl\n)\n\nresult\n\nParameter                                            ARM A        ARM B           ARM C    \n                                                    (N=134)      (N=134)         (N=132)   \n———————————————————————————————————————————————————————————————————————————————————————————\nUnadjusted comparison                                                                      \n  n                                                   68           73              62      \n  Mean                                               3.68         5.07            3.09     \n  Difference in Means                                             1.38            -0.59    \n    95% CI                                                    (-2.76, 5.53)   (-4.91, 3.73)\n    p-value                                                      0.5113          0.7873    \nAdjusted comparison (covariates BASE and STRATA1)                                          \n  n                                                   68           73              62      \n  Adjusted Mean                                      4.06         3.57            3.34     \n  Difference in Adjusted Means                                    -0.49           -0.72    \n    95% CI                                                    (-3.28, 2.29)   (-3.57, 2.12)\n    p-value                                                      0.7277          0.6165    \n\n\n\n\n\nCodelibrary(teal)\nlibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\narm_ref_comp &lt;- list(\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  ),\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADQS\", adqs),\n    code =\n      'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))\n       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adqs\"))',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_ancova(\n      label = \"ANCOVA table\",\n      dataname = \"ADQS\",\n      avisit = choices_selected(\n        choices = value_choices(adqs, \"AVISIT\"),\n        selected = \"WEEK 1 DAY 8\"\n      ),\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ACTARMCD\")),\n        selected = \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      aval_var = choices_selected(\n        choices = variable_choices(adqs, c(\"CHG\", \"AVAL\")),\n        selected = \"CHG\"\n      ),\n      cov_var = choices_selected(\n        choices = variable_choices(adqs, c(\"BASE\", \"STRATA1\", \"SEX\")),\n        selected = \"STRATA1\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adqs, \"PARAMCD\", \"PARAM\"),\n        selected = \"FKSI-FWB\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:00:17.7210 pid:7657 token:[] teal.modules.clinical Initializing tm_t_ancova\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/coxt02.html",
+    "href": "tables/efficacy/coxt02.html",
+    "title": "COXT02",
+    "section": "",
+    "text": "Analysis based on multivariable Cox models is usually not performed for the Clinical Study Report (CSR) or regulatory documents, serving exploratory purposes only (e.g. for publication). In practice, the model usually includes only the main effects (without interaction terms). It produces the estimates for each of the covariates included in the model. The analysis follows the same principles (i.e. stratified vs. unstratified analysis and tie handling) as the general Cox model analysis also used in COXT01. Since there is usually no pre-specified hypothesis testing for such analysis, the p-values must be interpreted with caution.\n\n\nData Setup\nMultivariable Cox Regression\nMultivariable Cox Regression  with Interaction Term\nMultivariable Cox Regression  Specifying Covariates\nMultivariable Cox Regression  Specifying Covariates from ADSUB\nMultivariable Cox Regression  Setting Strata, Ties, Alpha Level, Statistics\nMultivariable Cox Regression  with Selection Process for Covariates\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\nlibrary(broom)\n\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadtte &lt;- df_explicit_na(adtte)\n\nanl &lt;- adtte %&gt;%\n  filter(\n    PARAMCD == \"OS\",\n    SEX %in% c(\"F\", \"M\"),\n    RACE %in% c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\", \"WHITE\")\n  ) %&gt;%\n  mutate(\n    ARM = droplevels(relevel(ARM, \"B: Placebo\")),\n    SEX = droplevels(SEX),\n    RACE = droplevels(RACE)\n  ) %&gt;%\n  mutate(EVENT = 1 - CNSR) %&gt;%\n  var_relabel(\n    ARM = \"Planned Arm\",\n    SEX = \"Sex\",\n    RACE = \"Race\",\n    AGE = \"Age\"\n  )\n\n\n\n\nThe summarize_coxreg function fits, tidies and arranges a Cox regression model in a table layout using the rtables framework. For a multivariable Cox regression model, argument multivar must be set to TRUE. Arguments variables and control can be specified to set up the model (see ?summarize_coxreg for more details and customization options). All variables specified within variables must be present in the data used when building the table.\nTo see the same model as a data.frame object, these two arguments (as well as the data) can be passed to the fit_coxreg_multivar function, and the resulting list tidied using broom::tidy().\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARM\",\n  covariates = c(\"SEX\", \"AGE\")\n)\n\nlyt &lt;- basic_table() %&gt;%\n  summarize_coxreg(variables = variables, multivar = TRUE) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model   Hazard Ratio      95% CI      p-value\n——————————————————————————————————————————————————————————————————————————————\nTreatment:                                                                    \n  Planned Arm (reference = B: Placebo)                                 0.2643 \n    A: Drug X                                0.96       (0.66, 1.42)   0.8536 \n    C: Combination                           1.27       (0.88, 1.83)   0.2010 \nCovariate:                                                                    \n  Sex (reference = F)                                                         \n    M                                        1.09       (0.80, 1.48)   0.5987 \n  Age                                                                         \n    All                                      0.99       (0.97, 1.01)   0.5104 \n\n\n\n\nThe estimation of interaction terms is not supported.\nInteraction terms are not included in the GDSR. For this reason and because we must take precautions when fitting such models, this functionality has not been translated in fit_coxreg_multivar. Please remove interaction terms or, if required by the study, refer to the survival::coxph function. Aside from this, using tern the developer must add the necessary variables to the analysis dataset during pre-processing based on ADVS or ADSUB. An example can be found in DMT01.\n\n\nThis option is not supported.\nSee the Multivariable Cox Regression with Interaction Term tab for more details.\n\n\nThis option is not supported.\nSee the Multivariable Cox Regression with Interaction Term tab for more details.\n\n\nAdditional controls can be customized using control_coxreg (see ?control_coxreg) such as the ties calculation method and the confidence level. Stratification variables can be added via the strata element of the variables list.\n\nCodevariables &lt;- list(\n  time = \"AVAL\",\n  event = \"EVENT\",\n  arm = \"ARMCD\",\n  covariates = c(\"SEX\", \"AGE\"),\n  strata = \"RACE\"\n)\n\ncontrol &lt;- control_coxreg(\n  conf_level = 0.9,\n  ties = \"efron\"\n)\n\nlyt &lt;- basic_table() %&gt;%\n  summarize_coxreg(\n    variables = variables,\n    control = control,\n    multivar = TRUE,\n    .stats = c(\"hr\", \"ci\")\n  ) %&gt;%\n  append_topleft(\"Effect/Covariate Included in the Model\")\n\nresult &lt;- build_table(lyt = lyt, df = anl)\nresult\n\nEffect/Covariate Included in the Model   Hazard Ratio      90% CI   \n————————————————————————————————————————————————————————————————————\nTreatment:                                                          \n  Planned Arm Code (reference = ARM A)                              \n    ARM B                                    1.03       (0.74, 1.42)\n    ARM C                                    1.30       (0.96, 1.77)\nCovariate:                                                          \n  Sex (reference = F)                                               \n    M                                        1.08       (0.83, 1.40)\n  Age                                                               \n    All                                      0.99       (0.98, 1.01)\n\n\n\n\nSee the Multivariable Cox Regression with Interaction Term tab.\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'adsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADTTE\", adtte, code = 'adtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_coxreg(\n      label = \"Cox Reg.\",\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\", \"ACTARMCD\"), \"ARM\"),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adtte, \"PARAMCD\", \"PARAM\"), \"OS\"\n      ),\n      strata_var = choices_selected(\n        c(\"SEX\", \"STRATA1\", \"STRATA2\"), NULL\n      ),\n      cov_var = choices_selected(\n        c(\"AGE\", \"SEX\", \"RACE\"), c(\"AGE\", \"SEX\")\n      ),\n      multivariate = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:01:35.4413 pid:7853 token:[] teal.modules.clinical Initializing tm_t_coxreg\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] broom_1.0.5                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n[13] scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          \n[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        \n[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    \n[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        \n[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          \n[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       \n[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         \n[43] stringr_1.5.0         splines_4.3.1         assertthat_0.2.1     \n[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[49] sandwich_3.0-2        jsonlite_1.8.7        carData_3.0-5        \n[52] callr_3.7.3           car_3.1-2             teal.widgets_0.4.0   \n[55] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      \n[58] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             \n[61] codetools_0.2-19      stringi_1.7.12        gtable_0.3.4         \n[64] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[67] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[70] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[73] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[76] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[79] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[82] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[85] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[88] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/aovt01.html",
+    "href": "tables/efficacy/aovt01.html",
+    "title": "AOVT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\nadqs_multi &lt;- filter(adqs, AVISIT == \"WEEK 1 DAY 8\")\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nl &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  split_rows_by(\"PARAMCD\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adqs_multi$PARAMCD)\n  ) %&gt;%\n  summarize_ancova(\n    vars = \"CHG\",\n    variables = list(\n      arm = \"ARMCD\",\n      covariates = c(\"BASE\", \"STRATA1\")\n    ),\n    conf_level = 0.95,\n    var_labels = \"Adjusted mean\"\n  )\n\nresult &lt;- build_table(\n  lyt = l,\n  df = adqs_multi,\n  alt_counts_df = adsl\n)\n\nresult\n\nParameter Code                     ARM A       ARM B           ARM C    \n————————————————————————————————————————————————————————————————————————\nBFIALL                                                                  \n  Adjusted mean                                                         \n    n                               134         134             132     \n    Adjusted Mean                  4.47        6.33            4.02     \n    Difference in Adjusted Means               1.85            -0.46    \n      95% CI                               (-0.14, 3.85)   (-2.45, 1.54)\n      p-value                                 0.0679          0.6539    \nFATIGI                                                                  \n  Adjusted mean                                                         \n    n                               134         134             132     \n    Adjusted Mean                  5.42        4.83            4.56     \n    Difference in Adjusted Means               -0.59           -0.86    \n      95% CI                               (-2.58, 1.41)   (-2.87, 1.15)\n      p-value                                 0.5644          0.4026    \nFKSI-FWB                                                                \n  Adjusted mean                                                         \n    n                               134         134             132     \n    Adjusted Mean                  4.29        3.51            3.06     \n    Difference in Adjusted Means               -0.79           -1.24    \n      95% CI                               (-2.71, 1.14)   (-3.17, 0.69)\n      p-value                                 0.4221          0.2088    \nFKSI-TSE                                                                \n  Adjusted mean                                                         \n    n                               134         134             132     \n    Adjusted Mean                  4.70        3.84            4.45     \n    Difference in Adjusted Means               -0.86           -0.25    \n      95% CI                               (-2.80, 1.09)   (-2.20, 1.70)\n      p-value                                 0.3858          0.8007    \nFKSIALL                                                                 \n  Adjusted mean                                                         \n    n                               134         134             132     \n    Adjusted Mean                  5.03        5.82            6.44     \n    Difference in Adjusted Means               0.79            1.42     \n      95% CI                               (-1.17, 2.76)   (-0.56, 3.39)\n      p-value                                 0.4288          0.1591    \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadqs &lt;- synthetic_cdisc_dataset(\"latest\", \"adqs\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadqs &lt;- df_explicit_na(adqs)\n\narm_ref_comp &lt;- list(\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  ),\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADQS\", adqs),\n    code =\n      'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))\n       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adqs\"))',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_ancova(\n      label = \"ANCOVA table\",\n      dataname = \"ADQS\",\n      avisit = choices_selected(\n        choices = value_choices(adqs, \"AVISIT\"),\n        selected = \"WEEK 1 DAY 8\"\n      ),\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ACTARMCD\")),\n        selected = \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      aval_var = choices_selected(\n        choices = variable_choices(adqs, c(\"CHG\", \"AVAL\")),\n        selected = \"CHG\"\n      ),\n      cov_var = choices_selected(\n        choices = variable_choices(adqs, c(\"BASE\", \"STRATA1\", \"SEX\")),\n        selected = \"STRATA1\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adqs, \"PARAMCD\", \"PARAM\"),\n        selected = c(\"FKSI-FWB\", \"BFIALL\")\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:03:21.3759 pid:8051 token:[] teal.modules.clinical Initializing tm_t_ancova\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/efficacy/dort01.html",
+    "href": "tables/efficacy/dort01.html",
+    "title": "DORT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Selecting  Sections to Display\nTable Modifying Analysis Details  like Conf. Type and Alpha Level\nTable Modifying Time Point for  the “XX Months duration” Analysis\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadtte &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadtte &lt;- df_explicit_na(adtte)\n\nadtte_f &lt;- adtte %&gt;%\n  filter(PARAMCD == \"CRSD\" & BMEASIFL == \"Y\") %&gt;%\n  dplyr::mutate(\n    AVAL = day2month(AVAL),\n    is_event = CNSR == 0,\n    is_not_event = CNSR == 1,\n    EVNT1 = factor(\n      case_when(\n        is_event == TRUE ~ \"Responders with subsequent event (%)\",\n        is_event == FALSE ~ \"Responders without subsequent event (%)\"\n      ),\n      levels = c(\"Responders with subsequent event (%)\", \"Responders without subsequent event (%)\")\n    ),\n    EVNTDESC = factor(EVNTDESC)\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  count_values(\n    vars = \"USUBJID\",\n    values = unique(adtte$USUBJID),\n    .labels = \"Responders\",\n    .stats = \"count\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders with subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    show_labels = \"hidden\",\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Responders with subsequent event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 2L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders without subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Duration of response (Months)\",\n    is_event = \"is_event\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months duration\",\n    is_event = \"is_event\",\n    time_point = 12\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table(prune_func = prune_zeros_only)\n\nresult\n\n                                            A: Drug X    B: Placebo   C: Combination\n                                             (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————\nResponders                                      68           73             62      \n  Responders with subsequent event (%)      46 (67.6%)   39 (53.4%)     32 (51.6%)  \n    Earliest contributing event                                                     \n      Death                                     26           24             16      \n      Disease Progression                       20           15             16      \n  Responders without subsequent event (%)   22 (32.4%)   34 (46.6%)     30 (48.4%)  \nDuration of response (Months)                                                       \n  Median                                       5.3          6.2            5.3      \n    95% CI                                  (4.6, 5.8)   (5.4, 6.3)     (4.6, 5.8)  \n  25% and 75%-ile                            3.8, 6.3     4.6, 6.4       4.0, 6.1   \n  Range (censored)                          3.6 to 6.3   3.3 to 6.5     3.3 to 6.4  \n  Range (event)                             0.5 to 6.4   0.9 to 6.5     0.6 to 6.6  \n12 Months duration                                                                  \n  Patients remaining at risk                    NA           NA             NA      \n  Event Free Rate (%)                           NA           NA             NA      \n  95% CI                                        NA           NA             NA      \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  count_values(\n    vars = \"USUBJID\",\n    values = unique(adtte$USUBJID),\n    .labels = \"Responders\",\n    .stats = \"count\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders with subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    show_labels = \"hidden\",\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Responders with subsequent event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 2L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders without subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Duration of response (Months)\",\n    is_event = \"is_event\",\n    table_names = \"surv_time\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = c(\"Unstratified Analysis\"),\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"cox_pair\"\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table(prune_func = prune_zeros_only)\n\nresult\n\n                                            A: Drug X     B: Placebo    C: Combination\n                                             (N=134)       (N=134)         (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nResponders                                      68            73              62      \n  Responders with subsequent event (%)      46 (67.6%)    39 (53.4%)      32 (51.6%)  \n    Earliest contributing event                                                       \n      Death                                     26            24              16      \n      Disease Progression                       20            15              16      \n  Responders without subsequent event (%)   22 (32.4%)    34 (46.6%)      30 (48.4%)  \nDuration of response (Months)                                                         \n  Median                                       5.3           6.2             5.3      \n    95% CI                                  (4.6, 5.8)    (5.4, 6.3)      (4.6, 5.8)  \n  25% and 75%-ile                            3.8, 6.3      4.6, 6.4        4.0, 6.1   \n  Range (censored)                          3.6 to 6.3    3.3 to 6.5      3.3 to 6.4  \n  Range (event)                             0.5 to 6.4    0.9 to 6.5      0.6 to 6.6  \nUnstratified Analysis                                                                 \n  p-value (log-rank)                                        0.0223          0.6659    \n  Hazard Ratio                                               0.60            0.90     \n  95% CI                                                 (0.39, 0.93)    (0.57, 1.44) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  count_values(\n    vars = \"USUBJID\",\n    values = unique(adtte$USUBJID),\n    .labels = \"Responders\",\n    .stats = \"count\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders with subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    show_labels = \"hidden\",\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Responders with subsequent event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 2L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders without subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Duration of response (Months)\",\n    is_event = \"is_event\",\n    control = control_surv_time(conf_level = 0.90, conf_type = \"log-log\")\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months duration\",\n    is_event = \"is_event\",\n    time_point = 12,\n    control = control_surv_timepoint(conf_level = 0.975)\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table(prune_func = prune_zeros_only)\n\nresult\n\n                                            A: Drug X    B: Placebo   C: Combination\n                                             (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————\nResponders                                      68           73             62      \n  Responders with subsequent event (%)      46 (67.6%)   39 (53.4%)     32 (51.6%)  \n    Earliest contributing event                                                     \n      Death                                     26           24             16      \n      Disease Progression                       20           15             16      \n  Responders without subsequent event (%)   22 (32.4%)   34 (46.6%)     30 (48.4%)  \nDuration of response (Months)                                                       \n  Median                                       5.3          6.2            5.3      \n    90% CI                                  (4.6, 5.8)   (5.5, 6.3)     (4.6, 5.7)  \n  25% and 75%-ile                            3.8, 6.3     4.6, 6.4       4.0, 6.1   \n  Range (censored)                          3.6 to 6.3   3.3 to 6.5     3.3 to 6.4  \n  Range (event)                             0.5 to 6.4   0.9 to 6.5     0.6 to 6.6  \n12 Months duration                                                                  \n  Patients remaining at risk                    NA           NA             NA      \n  Event Free Rate (%)                           NA           NA             NA      \n  97.5% CI                                      NA           NA             NA      \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\", ref_group = \"A: Drug X\") %&gt;%\n  count_values(\n    vars = \"USUBJID\",\n    values = unique(adtte$USUBJID),\n    .labels = \"Responders\",\n    .stats = \"count\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"is_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders with subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    show_labels = \"hidden\",\n  ) %&gt;%\n  split_rows_by(\n    \"EVNT1\",\n    split_label = \"Earliest contributing event\",\n    split_fun = keep_split_levels(\"Responders with subsequent event (%)\"),\n    label_pos = \"visible\",\n    child_labels = \"hidden\",\n    indent_mod = 2L,\n  ) %&gt;%\n  analyze(\"EVNTDESC\") %&gt;%\n  analyze_vars(\n    vars = \"is_not_event\",\n    .stats = \"count_fraction\",\n    .labels = c(count_fraction = \"Responders without subsequent event (%)\"),\n    .indent_mods = c(count_fraction = 1L),\n    nested = FALSE,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = \"Duration of response (Months)\",\n    is_event = \"is_event\"\n  ) %&gt;%\n  surv_timepoint(\n    vars = \"AVAL\",\n    var_labels = \"Months duration\",\n    is_event = \"is_event\",\n    time_point = 6\n  )\n\nresult &lt;- build_table(lyt, df = adtte_f, alt_counts_df = adsl) %&gt;%\n  prune_table(prune_func = prune_zeros_only)\n\nresult\n\n                                              A: Drug X        B: Placebo     C: Combination\n                                               (N=134)          (N=134)          (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————————\nResponders                                        68               73               62      \n  Responders with subsequent event (%)        46 (67.6%)       39 (53.4%)       32 (51.6%)  \n    Earliest contributing event                                                             \n      Death                                       26               24               16      \n      Disease Progression                         20               15               16      \n  Responders without subsequent event (%)     22 (32.4%)       34 (46.6%)       30 (48.4%)  \nDuration of response (Months)                                                               \n  Median                                         5.3              6.2              5.3      \n    95% CI                                    (4.6, 5.8)       (5.4, 6.3)       (4.6, 5.8)  \n  25% and 75%-ile                              3.8, 6.3         4.6, 6.4         4.0, 6.1   \n  Range (censored)                            3.6 to 6.3       3.3 to 6.5       3.3 to 6.4  \n  Range (event)                               0.5 to 6.4       0.9 to 6.5       0.6 to 6.6  \n6 Months duration                                                                           \n  Patients remaining at risk                      10               18               7       \n  Event Free Rate (%)                           33.46            50.23            30.56     \n  95% CI                                    (20.88, 46.05)   (36.54, 63.92)   (13.56, 47.57)\n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(tern)\n\nADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nADSL &lt;- df_explicit_na(ADSL)\nADTTE &lt;- df_explicit_na(ADTTE)\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", ADSL, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% df_explicit_na()'),\n    cdisc_dataset(\"ADTTE\", ADTTE, code = 'ADTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adtte\") %&gt;% df_explicit_na()'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_tte(\n      label = \"Time To Event Table\",\n      dataname = \"ADTTE\",\n      arm_var = choices_selected(\n        variable_choices(ADSL, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(ADTTE, \"PARAMCD\", \"PARAM\"),\n        \"CRSD\"\n      ),\n      strata_var = choices_selected(\n        variable_choices(ADSL, c(\"SEX\", \"BMRKR2\")),\n        \"SEX\"\n      ),\n      time_points = choices_selected(c(6, 8), 6),\n      event_desc_var = choices_selected(\n        variable_choices(ADTTE, \"EVNTDESC\"),\n        \"EVNTDESC\",\n        fixed = TRUE\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:04:38.6385 pid:8221 token:[] teal.modules.clinical Initializing tm_t_tte\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disclosures/eudrat01.html",
+    "href": "tables/disclosures/eudrat01.html",
+    "title": "EUDRAT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\nDefine a trimming function get_adae_trimmed to filter for AEs of greater than 5% incidence rate.\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nadae_nonser &lt;- adae %&gt;% filter(AESER != \"Y\", SAFFL == \"Y\")\n\nget_adae_trimmed &lt;- function(adsl, adae, cutoff_rate) {\n  n_per_arm &lt;- adsl %&gt;%\n    dplyr::count(ARM)\n\n  anl_terms &lt;- adae %&gt;%\n    dplyr::group_by(ARM, AEBODSYS, AEDECOD) %&gt;%\n    dplyr::count(\n      unique_terms = n_distinct(USUBJID)\n    ) %&gt;%\n    dplyr::select(-n) %&gt;%\n    dplyr::ungroup()\n\n  anl_terms &lt;- dplyr::left_join(\n    anl_terms,\n    n_per_arm,\n    by = \"ARM\"\n  ) %&gt;%\n    dplyr::mutate(\n      ae_rate = unique_terms / n\n    ) %&gt;%\n    dplyr::filter(ae_rate &gt;= cutoff_rate) %&gt;%\n    dplyr::select(AEDECOD) %&gt;%\n    unique()\n\n  anl &lt;- dplyr::left_join(\n    anl_terms,\n    adae,\n    by = \"AEDECOD\"\n  )\n  anl\n}\n\nadae_trim &lt;- get_adae_trimmed(adsl, adae_nonser, cutoff_rate = 0.05)\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  summarize_patients_events_in_cols(\n    custom_label = \"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5% and number of events\"\n  ) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    nested = FALSE,\n    split_fun = split_fun,\n    indent_mod = -1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_trim$AEBODSYS)\n  ) %&gt;%\n  split_rows_by(\"AEDECOD\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adae_trim$AEDECOD)) %&gt;%\n  summarize_patients_events_in_cols(\n    col_split = FALSE\n  )\n\nresult &lt;- build_table(lyt, adae_trim)\nresult\n\nBody System or Organ Class                                                                                                                     A: Drug X                      B: Placebo                    C: Combination        \n  Dictionary-Derived Term                                                                                                            Patients (All)   Events (All)   Patients (All)   Events (All)   Patients (All)   Events (All)\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5% and number of events        106             360             112             367             112             421     \ncl A.1                                                                                                                                                                                                                            \n  dcd A.1.1.1.1                                                                                                                            50              64              45              62              63              88     \ncl B.2                                                                                                                                                                                                                            \n  dcd B.2.1.2.1                                                                                                                            49              65              44              62              52              66     \ncl C.1                                                                                                                                                                                                                            \n  dcd C.1.1.1.3                                                                                                                            43              55              46              63              43              64     \ncl C.2                                                                                                                                                                                                                            \n  dcd C.2.1.2.1                                                                                                                            35              48              48              53              55              65     \ncl D.1                                                                                                                                                                                                                            \n  dcd D.1.1.4.2                                                                                                                            48              66              42              55              50              64     \ncl D.2                                                                                                                                                                                                                            \n  dcd D.2.1.5.3                                                                                                                            47              62              58              72              57              74     \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       \n[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  \n[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disclosures/disclosurest01.html",
+    "href": "tables/disclosures/disclosurest01.html",
+    "title": "DISCLOSUREST01",
+    "section": "",
+    "text": "Patient Disposition Table  (CTgov & EudraCT)\nDemographic Table  (CTgov & EudraCT)\nEnrollment by Country  Table (EudraCT only)\nNon-Serious Adverse Events  Reported in \\(\\geq\\) 5% of Patients in Any  Treatment Group (CTgov & EudraCT)\nSerious Adverse Events, Fatal SAEs  and SAEs Related to Study Medication,  by Treatment Group (CTgov & EudraCT)\nDeath Table  (EudraCT only)\nReproducibility\n\n\n\nData Setup\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\nset.seed(1, kind = \"Mersenne-Twister\")\n\n# Add additional disposition variables to adsl.\nadsl0 &lt;- adsl %&gt;%\n  mutate(\n    STSTFL = case_when(\n      is.na(RANDDT) ~ \"N\",\n      TRUE ~ \"Y\"\n    ) %&gt;% as.factor(),\n    COMPSTUD = sample(\n      c(\"Y\", \"N\"),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor(),\n    STUDONS = sample(\n      c(\"Alive: On Treatment\", \"Alive: In Follow-up\", NA),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor(),\n    STDDRS = sample(\n      c(\n        \"Death\", \"Lost To Follow-Up\",\n        \"Protocol Violation\", \"Withdrawal By Subject\",\n        \"Other\"\n      ),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor(),\n    GOTTRT = ifelse(!is.na(ACTARMCD), \"Y\", \"N\") %&gt;%\n      as.factor(),\n    DISTRTFL = sample(\n      c(\"Y\", \"N\"),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor(),\n    TRTDRS = sample(\n      c(\n        \"ADVERSE EVENT\", \"PROGRESSIVE DISEASE\",\n        \"PHYSICIAN DECISION\", \"LACK OF EFFICACY\",\n        \"OTHER\"\n      ),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor(),\n    STUDONS = case_when(COMPSTUD == \"N\" ~ STUDONS),\n    STDDRS = case_when(COMPSTUD == \"N\" & is.na(STUDONS) ~ STDDRS),\n    DISSTDFL = case_when(!is.na(STDDRS) ~ \"Y\"),\n    DISTRTFL = case_when(GOTTRT == \"Y\" ~ DISTRTFL),\n    TRTDRS = case_when(DISTRTFL == \"Y\" ~ TRTDRS),\n    DRSCAT = case_when(\n      TRTDRS %in% c(\"ADVERSE EVENT\", \"PHYSICIAN DECISION\") ~ \"Safety\",\n      !is.na(TRTDRS) ~ \"Other\"\n    )\n  ) %&gt;%\n  var_relabel(\n    STSTFL = \"Started Study\",\n    COMPSTUD = \"Complete Study\",\n    STUDONS = \"On-study Status\",\n    DISSTDFL = \"Discontinued Study\",\n    STDDRS = \"Reason for Study Discontinuation\",\n    GOTTRT = \"Received Treatment\",\n    DISTRTFL = \"Discontinued Treatment\",\n    TRTDRS = \"Reason for Treatment Discontinuation\",\n    DRSCAT = \"Subcategory for Treatment Discontinuation\"\n  )\n\n\nPatient Disposition Table\n\nCode# Define the split function\nsplit_fun &lt;- keep_split_levels(\"Y\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_values(\"STSTFL\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Started Study\")\n  ) %&gt;%\n  count_values(\"COMPSTUD\",\n    values = \"Y\",\n    .labels = c(count_fraction = \"Completed Study\")\n  ) %&gt;%\n  split_rows_by(\n    \"DISSTDFL\",\n    split_fun = split_fun\n  ) %&gt;%\n  summarize_row_groups(label_fstr = \"Discontinued Study\") %&gt;%\n  analyze_vars(\n    \"STDDRS\",\n    .stats = \"count_fraction\"\n  ) %&gt;%\n  append_topleft(\"Status\")\n\nresult &lt;- build_table(lyt = lyt, df = adsl0)\nresult\n\nStatus                      A: Drug X      B: Placebo     C: Combination   All Patients \n                             (N=134)         (N=134)         (N=132)          (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————\nStarted Study             134 (100.00%)   134 (100.00%)   132 (100.00%)    400 (100.00%)\nCompleted Study            65 (48.51%)     67 (50.00%)     69 (52.27%)     201 (50.25%) \nDiscontinued Study         15 (11.2%)      28 (20.9%)       24 (18.2%)      67 (16.8%)  \n  Death                      6 (40%)        5 (17.9%)       4 (16.7%)       15 (22.4%)  \n  Lost To Follow-Up         1 (6.7%)        3 (10.7%)       8 (33.3%)       12 (17.9%)  \n  Other                     2 (13.3%)       6 (21.4%)       5 (20.8%)       13 (19.4%)  \n  Protocol Violation        4 (26.7%)       4 (14.3%)       4 (16.7%)       12 (17.9%)  \n  Withdrawal By Subject     2 (13.3%)      10 (35.7%)       3 (12.5%)       15 (22.4%)  \n\n\n\n\n\nData Setup\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\n# Change description in variable SEX.\nadsl &lt;- adsl %&gt;%\n  mutate(\n    SEX = factor(case_when(\n      SEX == \"M\" ~ \"Male\",\n      SEX == \"F\" ~ \"Female\",\n      SEX == \"U\" ~ \"Unknown\",\n      SEX == \"UNDIFFERENTIATED\" ~ \"Undifferentiated\"\n    )),\n    AGEGRP = factor(\n      case_when(\n        between(AGE, 18, 40) ~ \"18-40\",\n        between(AGE, 41, 64) ~ \"41-64\",\n        AGE &gt; 64 ~ \"&gt;=65\"\n      ),\n      levels = c(\"18-40\", \"41-64\", \"&gt;=65\")\n    )\n  )\n\n\nDemographic Table\n\nCodevars &lt;- c(\"AGE\", \"AGEGRP\", \"SEX\", \"RACE\", \"ETHNIC\")\nvar_labels &lt;- c(\"Age (yr)\", \"Age group\", \"Sex\", \"Race\", \"Ethnicity\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  analyze_vars(\n    vars = vars,\n    var_labels = var_labels\n  )\n\nresult &lt;- build_table(lyt = lyt, df = adsl)\nresult\n\n                                               A: Drug X    B: Placebo    C: Combination   All Patients\n                                                (N=134)       (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————————————————————————\nAge (yr)                                                                                               \n  n                                               134           134            132             400     \n  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)      34.9 (7.4) \n  Median                                         33.0          35.0            35.0            34.0    \n  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0     20.0 - 69.0 \nAge group                                                                                              \n  n                                               134           134            132             400     \n  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)     322 (80.5%) \n  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)      77 (19.2%) \n  &gt;=65                                             0             0           1 (0.8%)        1 (0.2%)  \nSex                                                                                                    \n  n                                               134           134            132             400     \n  Female                                       79 (59%)     82 (61.2%)       70 (53%)      231 (57.8%) \n  Male                                         55 (41%)     52 (38.8%)       62 (47%)      169 (42.2%) \nRace                                                                                                   \n  n                                               134           134            132             400     \n  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)      208 (52%)  \n  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)      91 (22.8%) \n  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)      74 (18.5%) \n  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)       25 (6.2%)  \n  MULTIPLE                                         0         1 (0.7%)           0            1 (0.2%)  \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0            1 (0.2%)  \n  OTHER                                            0             0              0               0      \n  UNKNOWN                                          0             0              0               0      \nEthnicity                                                                                              \n  n                                               134           134            132             400     \n  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)       27 (6.8%)  \n  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)       48 (12%)  \n  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)      308 (77%)  \n  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)       17 (4.2%)  \n\n\n\n\n\nData Setup\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsl_labels &lt;- var_labels(adsl)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\nadsl &lt;- adsl %&gt;%\n  mutate(COUNTRY = droplevels(COUNTRY)) %&gt;%\n  arrange(REGION1, COUNTRY)\n\nvar_labels(adsl) &lt;- c(adsl_labels)\n\n\nEnrollment by Country Table\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  analyze_vars(\"COUNTRY\") %&gt;%\n  append_varlabels(adsl, \"COUNTRY\")\n\nresult &lt;- build_table(lyt, adsl)\nresult\n\nCountry   A: Drug X    B: Placebo   C: Combination   All Patients\n           (N=134)      (N=134)        (N=132)         (N=400)   \n—————————————————————————————————————————————————————————————————\nn            134          134            132             400     \nCHN       74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) \nUSA       10 (7.5%)    13 (9.7%)      17 (12.9%)       40 (10%)  \nBRA       13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \nPAK        12 (9%)      9 (6.7%)      10 (7.6%)       31 (7.8%)  \nNGA         8 (6%)      7 (5.2%)      11 (8.3%)       26 (6.5%)  \nRUS        5 (3.7%)      8 (6%)        6 (4.5%)       19 (4.8%)  \nJPN        5 (3.7%)      4 (3%)        9 (6.8%)       18 (4.5%)  \nGBR         4 (3%)      3 (2.2%)       2 (1.5%)        9 (2.2%)  \nCAN        3 (2.2%)     2 (1.5%)       3 (2.3%)         8 (2%)   \n\n\n\n\n\nData Setup\nTrimming function get_adae_trimmed is defined to filter AEs with greater than 5% incidence rate.\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nadae_nonser &lt;- adae %&gt;% filter(AESER != \"Y\", SAFFL == \"Y\")\n\nget_adae_trimmed &lt;- function(adsl, adae, cutoff_rate) {\n  n_per_arm &lt;- adsl %&gt;%\n    dplyr::count(ARM)\n\n  anl_terms &lt;- adae %&gt;%\n    dplyr::group_by(ARM, AEBODSYS, AEDECOD) %&gt;%\n    dplyr::count(\n      unique_terms = n_distinct(USUBJID)\n    ) %&gt;%\n    dplyr::select(-n) %&gt;%\n    dplyr::ungroup()\n\n  anl_terms &lt;- dplyr::left_join(\n    anl_terms,\n    n_per_arm,\n    by = \"ARM\"\n  ) %&gt;%\n    dplyr::mutate(\n      ae_rate = unique_terms / n\n    ) %&gt;%\n    dplyr::filter(ae_rate &gt;= cutoff_rate) %&gt;%\n    dplyr::select(AEDECOD) %&gt;%\n    unique()\n\n  anl &lt;- dplyr::left_join(\n    anl_terms,\n    adae,\n    by = \"AEDECOD\"\n  )\n  anl\n}\n\nadae_trim &lt;- get_adae_trimmed(adsl, adae_nonser, cutoff_rate = 0.05)\n\n\nNon-Serious Adverse Events Report in \\(\\geq\\) 5% of Patients in Any Treatment Group\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  summarize_patients_events_in_cols(\n    custom_label = \"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5%\"\n  ) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    nested = FALSE,\n    split_fun = split_fun,\n    indent_mod = -1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_trim$AEBODSYS)\n  ) %&gt;%\n  split_rows_by(\"AEDECOD\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adae_trim$AEDECOD)) %&gt;%\n  summarize_patients_events_in_cols(\n    col_split = FALSE\n  )\n\nresult &lt;- build_table(lyt, adae_trim)\nresult\n\nBody System or Organ Class                                                                                                A: Drug X                      B: Placebo                    C: Combination        \n  Dictionary-Derived Term                                                                                       Patients (All)   Events (All)   Patients (All)   Events (All)   Patients (All)   Events (All)\n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5%        106             360             112             367             112             421     \ncl A.1                                                                                                                                                                                                       \n  dcd A.1.1.1.1                                                                                                       50              64              45              62              63              88     \ncl B.2                                                                                                                                                                                                       \n  dcd B.2.1.2.1                                                                                                       49              65              44              62              52              66     \ncl C.1                                                                                                                                                                                                       \n  dcd C.1.1.1.3                                                                                                       43              55              46              63              43              64     \ncl C.2                                                                                                                                                                                                       \n  dcd C.2.1.2.1                                                                                                       35              48              48              53              55              65     \ncl D.1                                                                                                                                                                                                       \n  dcd D.1.1.4.2                                                                                                       48              66              42              55              50              64     \ncl D.2                                                                                                                                                                                                       \n  dcd D.2.1.5.3                                                                                                       47              62              58              72              57              74     \n\n\n\n\n\nFor illustrative purposes, the adae data is filtered by arm “A: Drug X” here.\nData Setup\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadae &lt;- df_explicit_na(adae)\n\nadae_serious &lt;- adae %&gt;% filter(AESER == \"Y\", SAFFL == \"Y\")\nadae_serious_arm &lt;- adae_serious %&gt;% filter(ARM == \"A: Drug X\")\n\nfilters_list &lt;- list(\n  related = with_label(c(AEREL = \"Y\"), \"Events (Related)\"),\n  fatal = with_label(c(AESDTH = \"Y\"), \"Events (Fatal)\"),\n  fatal_related = with_label(c(AEREL = \"Y\", AESDTH = \"Y\"), \"Events (Fatal & Related)\")\n)\n\n\nSerious Adverse Events, Fatal SAEs and SAEs Related to Study Medication, by Treatment Group\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  summarize_patients_events_in_cols(\n    filters_list = filters_list,\n    empty_stats = c(\"all\", \"related\", \"fatal\", \"fatal_related\"),\n    custom_label = \"Total number of patients with at least one serious adverse event\"\n  ) %&gt;%\n  split_rows_by(\"AEBODSYS\",\n    nested = FALSE,\n    split_fun = split_fun,\n    indent_mod = -1L,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_trim$AEBODSYS)\n  ) %&gt;%\n  split_rows_by(\"AEDECOD\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae_serious_arm$AEDECOD)\n  ) %&gt;%\n  summarize_patients_events_in_cols(\n    filters_list = filters_list,\n    col_split = FALSE\n  )\n\nresult &lt;- build_table(lyt, adae_serious_arm)\nresult\n\nBody System or Organ Class                                                                                                                                     \n  Dictionary-Derived Term                                          Patients (All)   Events (All)   Events (Related)   Events (Fatal)   Events (Fatal & Related)\n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one serious adverse event        104                                                                                    \ncl A.1                                                                                                                                                         \n  dcd A.1.1.1.2                                                          48              68               0                 0                     0            \ncl B.1                                                                                                                                                         \n  dcd B.1.1.1.1                                                          47              56               56                56                    56           \ncl B.2                                                                                                                                                         \n  dcd B.2.2.3.1                                                          48              64               0                 0                     0            \ncl D.1                                                                                                                                                         \n  dcd D.1.1.1.1                                                          50              61               61                61                    61           \n\n\n\n\n\nData Setup\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n\nDeath Table\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"AESDTH\" = \"Y\"),\n    .labels = c(count_fraction = \"Total Number of Deaths\"),\n    .formats = c(count_fraction = \"xx (xx.xx%)\")\n  )\nresult &lt;- build_table(lyt, adae, alt_counts_df = adsl)\nresult\n\n                          A: Drug X    B: Placebo    C: Combination   All Patients\n                           (N=134)       (N=134)        (N=132)         (N=400)   \n——————————————————————————————————————————————————————————————————————————————————\nTotal Number of Deaths   76 (62.30%)   70 (56.91%)    75 (62.50%)     221 (60.55%)\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       \n[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  \n[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/vital-signs/vst02.html",
+    "href": "tables/vital-signs/vst02.html",
+    "title": "VST02",
+    "section": "",
+    "text": "Data Setup\nVST02_1 – Table of Abnormalities  Regardless of Abnormality at Baseline\nVST02_2 – Table of Abnormalities Among  Subjects Without Abnormality at Baseline\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\")\n\n# Ensure character variables are converted to factors and empty strings\n# and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadvs &lt;- df_explicit_na(advs)\n\n# Note:  We keep only post-baseline for analysis.\nadvs_f &lt;- advs %&gt;%\n  filter(ONTRTFL == \"Y\", ANRIND != \"&lt;Missing&gt;\") %&gt;%\n  var_relabel(\n    PARAM = \"Assessment\",\n    ANRIND = \"Abnormality\"\n  )\n\n# If you want to control which parameters in the table have only `LOW` or only `HIGH` theoretical ranges defined,\n# see `tern::h_map_for_count_abnormal` with method \"range\" or refer to the `EGT02` example.\n# For `VST02` we want to keep both directions for all parameters so we will not use `trim_levels_to_map` as the split function.\nsplit_fun &lt;- drop_split_levels\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(advs_f$PARAM)) %&gt;%\n  count_abnormal(\n    \"ANRIND\",\n    abnormal = list(Low = c(\"LOW\", \"LOW LOW\"), High = c(\"HIGH\", \"HIGH HIGH\")),\n    exclude_base_abn = FALSE\n  ) %&gt;%\n  append_varlabels(advs_f, \"ANRIND\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = advs_f, alt_counts_df = adsl)\n\nresult\n\nAssessment                    A: Drug X        B: Placebo      C: Combination     All Patients  \n  Abnormality                  (N=134)           (N=134)           (N=132)           (N=400)    \n————————————————————————————————————————————————————————————————————————————————————————————————\nDiastolic Blood Pressure                                                                        \n  Low                      66/134 (49.3%)    86/134 (64.2%)    78/132 (59.1%)    230/400 (57.5%)\n  High                     88/134 (65.7%)    70/134 (52.2%)    76/132 (57.6%)    234/400 (58.5%)\nPulse Rate                                                                                      \n  Low                      58/134 (43.3%)    32/134 (23.9%)    48/132 (36.4%)    138/400 (34.5%)\n  High                     53/134 (39.6%)    49/134 (36.6%)    44/132 (33.3%)    146/400 (36.5%)\nRespiratory Rate                                                                                \n  Low                      97/134 (72.4%)    84/134 (62.7%)    98/132 (74.2%)    279/400 (69.8%)\n  High                     96/134 (71.6%)    98/134 (73.1%)    98/132 (74.2%)     292/400 (73%) \nSystolic Blood Pressure                                                                         \n  Low                       71/134 (53%)     77/134 (57.5%)    73/132 (55.3%)    221/400 (55.2%)\n  High                     78/134 (58.2%)    74/134 (55.2%)    73/132 (55.3%)    225/400 (56.2%)\nTemperature                                                                                     \n  Low                      108/134 (80.6%)   110/134 (82.1%)   108/132 (81.8%)   326/400 (81.5%)\n  High                     112/134 (83.6%)   106/134 (79.1%)   107/132 (81.1%)   325/400 (81.2%)\nWeight                                                                                          \n  Low                      43/134 (32.1%)    39/134 (29.1%)    39/132 (29.5%)    121/400 (30.2%)\n  High                     46/134 (34.3%)    43/134 (32.1%)    44/132 (33.3%)    133/400 (33.2%)\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ACTARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(advs_f$PARAM)) %&gt;%\n  count_abnormal(\n    \"ANRIND\",\n    abnormal = list(Low = c(\"LOW\", \"LOW LOW\"), High = c(\"HIGH\", \"HIGH HIGH\")),\n    exclude_base_abn = TRUE\n  ) %&gt;%\n  append_varlabels(advs_f, \"ANRIND\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = advs_f, alt_counts_df = adsl)\n\nresult\n\nAssessment                   A: Drug X        B: Placebo     C: Combination    All Patients  \n  Abnormality                 (N=134)          (N=134)          (N=132)           (N=400)    \n—————————————————————————————————————————————————————————————————————————————————————————————\nDiastolic Blood Pressure                                                                     \n  Low                       54/108 (50%)    76/116 (65.5%)   68/114 (59.6%)   198/338 (58.6%)\n  High                     74/114 (64.9%)   56/109 (51.4%)   62/106 (58.5%)   192/329 (58.4%)\nPulse Rate                                                                                   \n  Low                      53/121 (43.8%)    30/125 (24%)    42/119 (35.3%)   125/365 (34.2%)\n  High                      48/123 (39%)    45/116 (38.8%)   39/120 (32.5%)   132/359 (36.8%)\nRespiratory Rate                                                                             \n  Low                       72/100 (72%)    72/110 (65.5%)   79/102 (77.5%)   223/312 (71.5%)\n  High                      77/107 (72%)    78/108 (72.2%)   79/109 (72.5%)   234/324 (72.2%)\nSystolic Blood Pressure                                                                      \n  Low                       62/117 (53%)    63/114 (55.3%)   57/103 (55.3%)   182/334 (54.5%)\n  High                     64/110 (58.2%)   67/120 (55.8%)   68/115 (59.1%)   199/345 (57.7%)\nTemperature                                                                                  \n  Low                      77/96 (80.2%)     78/94 (83%)     74/90 (82.2%)    229/280 (81.8%)\n  High                     78/93 (83.9%)    73/92 (79.3%)     81/100 (81%)    232/285 (81.4%)\nWeight                                                                                       \n  Low                      42/129 (32.6%)   37/125 (29.6%)   37/123 (30.1%)   116/377 (30.8%)\n  High                     41/126 (32.5%)   41/124 (33.1%)   42/121 (34.7%)   124/371 (33.4%)\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadvs &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\") %&gt;%\n  mutate(ONTRTFL = ifelse(AVISIT %in% c(\"SCREENING\", \"BASELINE\"), \"\", \"Y\")) %&gt;%\n  var_relabel(ONTRTFL = \"On Treatment Record Flag\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADVS\", advs, code = 'ADVS &lt;- synthetic_cdisc_dataset(\"latest\", \"advs\") %&gt;%\n      mutate(ONTRTFL = ifelse(AVISIT %in% c(\"SCREENING\", \"BASELINE\"), \"\", \"Y\")) %&gt;%\n      var_relabel(ONTRTFL = \"On Treatment Record Flag\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_abnormality(\n      label = \"Abnormality Table\",\n      dataname = \"ADVS\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(advs, subset = c(\"VSCAT\", \"PARAM\", \"AVISIT\")),\n        selected = c(\"PARAM\"),\n        keep_order = TRUE\n      ),\n      grade = choices_selected(\n        choices = variable_choices(advs, subset = \"ANRIND\"),\n        selected = \"ANRIND\",\n        fixed = TRUE\n      ),\n      abnormal = list(Low = c(\"LOW\", \"LOW LOW\"), High = c(\"HIGH\", \"HIGH HIGH\")),\n      exclude_base_abn = FALSE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:07:21.4427 pid:8623 token:[] teal.modules.clinical Initializing tm_t_abnormality\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/concomitant-medications/cmt02_pt.html",
+    "href": "tables/concomitant-medications/cmt02_pt.html",
+    "title": "CMT02_PT",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nadcm$CMSEQ &lt;- as.factor(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\nadsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\nadcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\n\n# Keep only safety-evaluable patients and concomitant medications\nadsl &lt;- adsl %&gt;%\n  filter(SAFFL == \"Y\")\n\n# Keep only concomitant medications\nadcm &lt;- adcm %&gt;% filter(ATIREL == \"CONCOMITANT\")\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    ),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\") %&gt;%\n  append_topleft(paste(\"\\nOther Treatment\"))\n\nresult &lt;- build_table(lyt = lyt, df = adcm, alt_counts_df = adsl) %&gt;%\n  sort_at_path(\n    path = c(\"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\n                                                        A: Drug X    B: Placebo    C: Combination   All Patients\nOther Treatment                                          (N=134)       (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment   117 (87.3%)   116 (86.6%)    116 (87.9%)     349 (87.2%) \nTotal number of treatments                                 415           414            460             1289    \nmedname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)     170 (42.5%) \nmedname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)     168 (42.0%) \nmedname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)     159 (39.8%) \nmedname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)     157 (39.2%) \nmedname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)     150 (37.5%) \nmedname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)     147 (36.8%) \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nadcm$CMSEQ &lt;- as.integer(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\n# adsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\n# adcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\nadcm_keys &lt;- c(\"STUDYID\", \"USUBJID\", \"ASTDTM\", \"CMSEQ\", \"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = '\n                  ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n                  ADSL &lt;- df_explicit_na(ADSL)\n                  '),\n    cdisc_dataset(\"ADCM\", adcm,\n      code = '\n      ADCM &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n      ADCM$CMID &lt;- as.factor(ADCM$CMSEQ)\n      ADCM &lt;- df_explicit_na(ADCM)\n      ',\n      keys = adcm_keys\n    )\n  ),\n  modules = modules(\n    tm_t_mult_events(\n      label = \"Concomitant Medications by Medication Class and Preferred Name\",\n      dataname = \"ADCM\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      seq_var = choices_selected(\"CMSEQ\", selected = \"CMSEQ\", fixed = TRUE),\n      hlt = choices_selected(\n        choices = variable_choices(adcm, c(\"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")),\n        selected = c(\"ATC1\")\n      ),\n      llt = choices_selected(\n        choices = variable_choices(adcm, c(\"CMDECOD\")),\n        selected = c(\"CMDECOD\")\n      ),\n      add_total = TRUE,\n      event_type = \"treatment\"\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\"),\n    ADCM = list(ATIREL = \"CONCOMITANT\")\n  )\n)\n\n[INFO] 2023-09-25 11:08:20.5132 pid:8820 token:[] teal.modules.clinical Initializing tm_t_mult_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/concomitant-medications/cmt01a.html",
+    "href": "tables/concomitant-medications/cmt01a.html",
+    "title": "CMT01A",
+    "section": "",
+    "text": "Data Setup\nStandard Table,  Safety-Evaluable Patients\nTable Changing  ATC Class Level\nTable with Classes  Sorted by Frequency\nTable with Total Number of Treatments  per Medication Class Suppressed\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n\nadcm$CMSEQ &lt;- as.factor(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\n# adsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\n# adcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\n# Keep only safety-evaluable patients and concomitant medications\nadsl &lt;- adsl %&gt;%\n  filter(SAFFL == \"Y\")\n\nadcm &lt;- adcm %&gt;%\n  filter(SAFFL == \"Y\" & ATIREL == \"CONCOMITANT\") %&gt;%\n  var_relabel(CMDECOD = \"Other Treatment\")\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adcm, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC2\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination\n  Other Treatment                                          (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                   415           414            460      \nATCCLAS2 A                                                                                         \n  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n  Total number of treatments                                 134           137            143      \n  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS2 A p2                                                                                      \n  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n  Total number of treatments                                 58            66              64      \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS2 B                                                                                         \n  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n  Total number of treatments                                 141           137            162      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS2 B p2                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 B p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 C                                                                                         \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 C p2                                                                                      \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 C p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  Total number of treatments                                 69            73              80      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC1\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC1)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adcm, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC1\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 1 Text                                          A: Drug X    B: Placebo    C: Combination\n  Other Treatment                                          (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                   415           414            460      \nATCCLAS1 A                                                                                         \n  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n  Total number of treatments                                 134           137            143      \n  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS1 A p2                                                                                      \n  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n  Total number of treatments                                 58            66              64      \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS1 B                                                                                         \n  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n  Total number of treatments                                 141           137            162      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS1 B p2                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS1 B p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS1 C                                                                                         \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS1 C p2                                                                                      \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS1 C p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  Total number of treatments                                 69            73              80      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adcm, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(path = c(\"ATC2\"), scorefun = cont_n_allcols) %&gt;%\n  sort_at_path(path = c(\"ATC2\", \"*\", \"CMDECOD\"), scorefun = score_occurrences)\n\nresult\n\nATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination\n  Other Treatment                                          (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                   415           414            460      \nATCCLAS2 C                                                                                         \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 C p2                                                                                      \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  Total number of treatments                                 140           140            155      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 B                                                                                         \n  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n  Total number of treatments                                 141           137            162      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS2 A                                                                                         \n  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n  Total number of treatments                                 134           137            143      \n  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS2 C p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  Total number of treatments                                 69            73              80      \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \nATCCLAS2 B p2                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 B p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  Total number of treatments                                 75            82              83      \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 A p2                                                                                      \n  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n  Total number of treatments                                 58            66              64      \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\",\n      nonunique = \"Total number of treatments\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"ATC2\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adcm$ATC2)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    count_by = \"CMSEQ\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one treatment\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"CMDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adcm, \"CMDECOD\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adcm, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  # Sort lowest level terms by descending frequency.\n  sort_at_path(\n    path = c(\"ATC2\", \"*\", \"CMDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination\n  Other Treatment                                          (N=134)       (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  \nTotal number of treatments                                   415           414            460      \nATCCLAS2 A                                                                                         \n  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  \n  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS2 A p2                                                                                      \n  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  \n  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  \nATCCLAS2 B                                                                                         \n  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  \nATCCLAS2 B p2                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 B p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  \n  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  \nATCCLAS2 C                                                                                         \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 C p2                                                                                      \n  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  \nATCCLAS2 C p3                                                                                      \n  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  \n  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadcm &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\nadcm$CMSEQ &lt;- as.integer(adcm$CMSEQ)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\n# If you want your missing levels to show as \"No Coding Available\", please use\n# adsl &lt;- df_explicit_na(adsl, na_level = \"No Coding Available\")\n# adcm &lt;- df_explicit_na(adcm, na_level = \"No Coding Available\")\nadsl &lt;- df_explicit_na(adsl)\nadcm &lt;- df_explicit_na(adcm)\n\nadcm_keys &lt;- c(\"STUDYID\", \"USUBJID\", \"ASTDTM\", \"CMSEQ\", \"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = '\n                  ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n                  ADSL &lt;- df_explicit_na(ADSL)\n                  '),\n    cdisc_dataset(\"ADCM\", adcm,\n      code = '\n      ADCM &lt;- synthetic_cdisc_dataset(\"latest\", \"adcm\")\n      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)\n      ADCM &lt;- df_explicit_na(ADCM)\n      ',\n      keys = adcm_keys\n    )\n  ),\n  modules = modules(\n    tm_t_mult_events(\n      label = \"Concomitant Medications by Medication Class and Preferred Name\",\n      dataname = \"ADCM\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      seq_var = choices_selected(\"CMSEQ\", selected = \"CMSEQ\", fixed = TRUE),\n      hlt = choices_selected(\n        choices = variable_choices(adcm, c(\"ATC1\", \"ATC2\", \"ATC3\", \"ATC4\")),\n        selected = c(\"ATC2\")\n      ),\n      llt = choices_selected(\n        choices = variable_choices(adcm, c(\"CMDECOD\")),\n        selected = c(\"CMDECOD\")\n      ),\n      add_total = FALSE,\n      event_type = \"treatment\"\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\"),\n    ADCM = list(ATIREL = \"CONCOMITANT\")\n  )\n)\n\n[INFO] 2023-09-25 11:09:43.1409 pid:9017 token:[] teal.modules.clinical Initializing tm_t_mult_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt04.html",
+    "href": "tables/pharmacokinetic/pkpt04.html",
+    "title": "PKPT04",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp &lt;- adpp %&gt;% filter(PPSPEC == \"Urine\", AVISIT == \"CYCLE 1 DAY 1\")\n\n\n\n\n\nCode# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ARMCD\"),\n    # label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_label = \"PK Parameter\"\n  ) %&gt;%\n  tern::analyze_vars(\n    vars = \"AVAL\",\n    .stats = c(\"n\", \"mean_sd\", \"cv\", \"geom_mean\", \"geom_cv\", \"median\", \"range\"),\n    .formats = c(\n      n = \"xx.\",\n      mean_sd = sprintf_format(\"%.3e (%.3e)\"),\n      cv = \"xx.x\",\n      geom_mean = sprintf_format(\"%.3e\"),\n      geom_cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      range = sprintf_format(\"%.3e - %.3e\")\n    )\n  )\n\n\nPlasma Drug X\n\nCodeadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp0$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n—————————————————————————————————————————————————————————————————————\nPK Parameter                    ARM A                   ARM C        \n—————————————————————————————————————————————————————————————————————\nAe (mg)                                                              \n  n                              268                     264         \n  Mean (SD)             1.551e+00 (3.385e-01)   1.535e+00 (2.978e-01)\n  CV (%)                        21.8                    19.4         \n  Geometric Mean              1.513e+00               1.505e+00      \n  CV % Geometric Mean           23.0                    20.3         \n  Median                      1.547e+00               1.547e+00      \n  Min - Max             7.021e-01 - 2.464e+00   8.502e-01 - 2.208e+00\nFe (%)                                                               \n  n                              268                     264         \n  Mean (SD)             1.571e+01 (3.348e+00)   1.609e+01 (3.103e+00)\n  CV (%)                        21.3                    19.3         \n  Geometric Mean              1.534e+01               1.578e+01      \n  CV % Geometric Mean           22.2                    20.2         \n  Median                      1.577e+01               1.604e+01      \n  Min - Max             8.147e+00 - 2.452e+01   8.503e+00 - 2.443e+01\nCLR (L/hr)                                                           \n  n                              134                     132         \n  Mean (SD)             4.918e-02 (9.611e-03)   5.024e-02 (1.050e-02)\n  CV (%)                        19.5                    20.9         \n  Geometric Mean              4.818e-02               4.913e-02      \n  CV % Geometric Mean           21.0                    21.9         \n  Median                      4.909e-02               4.984e-02      \n  Min - Max             2.488e-02 - 7.511e-02   2.505e-02 - 8.560e-02\nRENALCLD (L/hr/mg)                                                   \n  n                              134                     132         \n  Mean (SD)             4.873e-03 (9.654e-04)   5.110e-03 (9.339e-04)\n  CV (%)                        19.8                    18.3         \n  Geometric Mean              4.772e-03               5.019e-03      \n  CV % Geometric Mean           21.2                    19.7         \n  Median                      4.967e-03               5.151e-03      \n  Min - Max             2.385e-03 - 7.258e-03   2.356e-03 - 7.407e-03\n\n\nPlasma Drug Y\n\nCodeadpp1 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug Y\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp1)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp1$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp1$PPCAT), \"\\nVisit:\", unique(adpp1$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug Y \nVisit: CYCLE 1 DAY 1\n\n—————————————————————————————————————————————\nPK Parameter                    ARM C        \n—————————————————————————————————————————————\nAe (mg)                                      \n  n                              264         \n  Mean (SD)             1.598e+00 (3.154e-01)\n  CV (%)                        19.7         \n  Geometric Mean              1.565e+00      \n  CV % Geometric Mean           21.4         \n  Median                      1.603e+00      \n  Min - Max             8.574e-01 - 2.257e+00\nFe (%)                                       \n  n                              264         \n  Mean (SD)             1.583e+01 (3.077e+00)\n  CV (%)                        19.4         \n  Geometric Mean              1.552e+01      \n  CV % Geometric Mean           20.2         \n  Median                      1.570e+01      \n  Min - Max             8.311e+00 - 2.378e+01\nCLR (L/hr)                                   \n  n                              132         \n  Mean (SD)             4.966e-02 (1.009e-02)\n  CV (%)                        20.3         \n  Geometric Mean              4.857e-02      \n  CV % Geometric Mean           22.0         \n  Median                      4.912e-02      \n  Min - Max             1.839e-02 - 7.761e-02\nRENALCLD (L/hr/mg)                           \n  n                              132         \n  Mean (SD)             5.093e-03 (1.032e-03)\n  CV (%)                        20.3         \n  Geometric Mean              4.985e-03      \n  CV % Geometric Mean           21.4         \n  Median                      5.017e-03      \n  Min - Max             2.356e-03 - 7.939e-03\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      \n[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      \n[45] pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt07.html",
+    "href": "tables/pharmacokinetic/pkpt07.html",
+    "title": "PKPT07",
+    "section": "",
+    "text": "Data Setup\nStandard Table – Urine\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\nlibrary(stringr)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\nadpp &lt;- adpp %&gt;% filter(AVISIT == \"CYCLE 1 DAY 1\", str_detect(tolower(PARAM), regex(\"norm by dose\", ignore_case = TRUE)))\n\n\n\n\n\nCode# lyt creation\nlyt &lt;- basic_table() %&gt;%\n  split_rows_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ARMCD\"),\n    label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  split_rows_by(\n    var = \"PKPARAM\",\n    label_pos = \"topleft\",\n    split_label = \"PK Parameter\",\n    child_labels = \"hidden\"\n  ) %&gt;%\n  analyze_vars_in_cols(\n    vars = \"AVAL\",\n    .stats = c(\n      \"n\", \"mean\", \"sd\", \"cv\",\n      \"geom_mean\", \"geom_cv\", \"median\",\n      \"min\", \"max\"\n    ),\n    .labels = c(\n      n = \"n\",\n      mean = \"Mean\",\n      sd = \"SD\",\n      cv = \"CV (%)\",\n      geom_mean = \"Geometric Mean\",\n      geom_cv = \"CV % Geometric Mean\",\n      median = \"Median\",\n      min = \"Minimum\",\n      max = \"Maximum\"\n    ),\n    .formats = c(\n      n = \"xx.\",\n      mean = sprintf_format(\"%.3e\"),\n      sd = sprintf_format(\"%.3e\"),\n      cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      geom_mean = sprintf_format(\"%.3e\"),\n      geom_cv = \"xx.x\",\n      min = sprintf_format(\"%.3e\"),\n      max = sprintf_format(\"%.3e\")\n    )\n  )\n\n\nPlasma Drug X\n\nCodeadpp0 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug X\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp0$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Arm                                                                                                                         \n  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nARM A                                                                                                                                 \n  RENALCLD (L/hr/mg)   134   4.873e-03   9.654e-04    19.8      4.772e-03             21.2           4.967e-03   2.385e-03   7.258e-03\nARM C                                                                                                                                 \n  RENALCLD (L/hr/mg)   132   5.110e-03   9.339e-04    18.3      5.019e-03             19.7           5.151e-03   2.356e-03   7.407e-03\n\n\nPlasma Drug Y\n\nCodeadpp1 &lt;- adpp %&gt;%\n  filter(PPCAT == \"Plasma Drug Y\") %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))) %&gt;%\n  mutate(PKPARAM = reorder(PKPARAM, TLG_ORDER))\n\nresult &lt;- build_table(lyt, df = adpp1)\nmain_title(result) &lt;- paste(\"Summary of\", unique(adpp1$PPSPEC), \"PK Parameter by Treatment Arm, PK Population\")\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp1$PPCAT), \"\\nVisit:\", unique(adpp1$AVISIT))\nresult\n\nSummary of Urine PK Parameter by Treatment Arm, PK Population\nAnalyte: Plasma Drug Y \nVisit: CYCLE 1 DAY 1\n\n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTreatment Arm                                                                                                                         \n  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nARM C                                                                                                                                 \n  RENALCLD (L/hr/mg)   132   5.093e-03   1.032e-03    20.3      4.985e-03             21.4           5.017e-03   2.356e-03   7.939e-03\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] stringr_1.5.0    tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   stringi_1.7.12    broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkct01.html",
+    "href": "tables/pharmacokinetic/pkct01.html",
+    "title": "PKCT01",
+    "section": "",
+    "text": "Data Setup\nteal App\nReproducibility\n\n\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nloaded via a namespace (and not attached):\n [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    \n [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  \n [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   \n[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    \n[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2\n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/pharmacokinetic/pkpt08.html",
+    "href": "tables/pharmacokinetic/pkpt08.html",
+    "title": "PKPT08",
+    "section": "",
+    "text": "Data Setup\nStandard Table – Plasma\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(tern)\n\nadpp &lt;- synthetic_cdisc_dataset(\"latest\", \"adpp\")\n\nadpp &lt;- adpp %&gt;%\n  filter(PPSTINT != \"NA\" & PPENINT != \"NA\") %&gt;%\n  mutate(PPINT = factor(paste0(gsub(\"[PH]\", \"\", PPSTINT), \"-\", gsub(\"[PH]\", \"\", PPENINT))))\n\n\n\n\n\nCode# create layout\nlyt &lt;- basic_table() %&gt;%\n  add_overall_col(\"Accumulation Interval (hours)\") %&gt;%\n  split_cols_by(var = \"PPINT\") %&gt;%\n  split_cols_by(var = \"PKPARAM\") %&gt;%\n  split_rows_by(\n    var = \"ARMCD\",\n    split_fun = trim_levels_in_group(\"ACTARM\"),\n    label_pos = \"topleft\",\n    split_label = \"Treatment Arm\"\n  ) %&gt;%\n  analyze_vars(\n    vars = \"AVAL\",\n    .stats = c(\n      \"n\", \"mean\", \"sd\", \"cv\",\n      \"median\", \"min\", \"max\"\n    ),\n    .labels = c(\n      n = \"n\",\n      mean = \"Mean\",\n      sd = \"SD\",\n      cv = \"CV (%)\",\n      median = \"Median\",\n      min = \"Minimum\",\n      max = \"Maximum\"\n    ),\n    .formats = c(\n      n = \"xx.\",\n      mean = sprintf_format(\"%.3e\"),\n      sd = sprintf_format(\"%.3e\"),\n      cv = \"xx.x\",\n      median = sprintf_format(\"%.3e\"),\n      min = sprintf_format(\"%.3e\"),\n      max = sprintf_format(\"%.3e\")\n    )\n  )\n\nadpp0 &lt;- adpp %&gt;%\n  filter(\n    AVISIT == \"CYCLE 1 DAY 1\",\n    PPCAT == \"Plasma Drug X\"\n  ) %&gt;%\n  h_pkparam_sort() %&gt;%\n  mutate(\n    PKPARAM = factor(paste0(TLG_DISPLAY, \" (\", AVALU, \")\"))\n  )\n\nresult &lt;- build_table(lyt, df = adpp0)\nmain_title(result) &lt;- paste(\n  \"Summary of Cumulative Amount and Percentage of\", unique(adpp0$PPSPEC), \"Recovered from\\n\",\n  unique(adpp0$PPCAT), \"following\", unique(adpp0$REGIMEN), \"Administration for\",\n  unique(adpp0$PPINT)[length(unique(adpp0$PPINT))], \"hours, PK Population\"\n)\nsubtitles(result) &lt;- paste(\"Analyte:\", unique(adpp0$PPCAT), \"\\nVisit:\", unique(adpp0$AVISIT))\n\ncat(rtables::toString(result, indent_size = 10))\n\nSummary of Cumulative Amount and Percentage of Urine Recovered from\n Plasma Drug X following BID Administration for 0-24 hours, PK Population\nAnalyte: Plasma Drug X \nVisit: CYCLE 1 DAY 1\n\n—————————————————————————————————————————————————————————————————\nTreatment Arm               Accumulation Interval (hours)        \n                            0-12                    0-24         \n                     Ae (mg)     Fe (%)      Ae (mg)     Fe (%)  \n—————————————————————————————————————————————————————————————————\nARM A                                                            \n          n            134         134         134         134   \n          Mean      1.551e+00   1.571e+01   1.551e+00   1.571e+01\n          SD        3.391e-01   3.354e+00   3.391e-01   3.354e+00\n          CV (%)      21.9        21.4        21.9        21.4   \n          Median    1.547e+00   1.577e+01   1.547e+00   1.577e+01\n          Minimum   7.021e-01   8.147e+00   7.021e-01   8.147e+00\n          Maximum   2.464e+00   2.452e+01   2.464e+00   2.452e+01\nARM C                                                            \n          n            132         132         132         132   \n          Mean      1.535e+00   1.609e+01   1.535e+00   1.609e+01\n          SD        2.983e-01   3.109e+00   2.983e-01   3.109e+00\n          CV (%)      19.4        19.3        19.4        19.3   \n          Median    1.547e+00   1.604e+01   1.547e+00   1.604e+01\n          Minimum   8.502e-01   8.503e+00   8.502e-01   8.503e+00\n          Maximum   2.208e+00   2.443e+01   2.208e+00   2.443e+01\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] scda_0.1.6       dplyr_1.1.3     \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  \n[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       \n[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    \n[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      \n[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      \n[45] pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ECG/egt01.html",
+    "href": "tables/ECG/egt01.html",
+    "title": "EGT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\n# Data should be filtered for the studied Parameter (`PARAM`) and the\n# Analysis Visit (`AVISIT`). According to the GDSR template, the values for\n# the `AVISIT` reported in the EGT01 standard may be:\n# 'POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST'.\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg)\n\nadeg_f &lt;- adeg %&gt;%\n  filter(ANL01FL == \"Y\") %&gt;%\n  filter(PARAM %in% c(\"Heart Rate\", \"QT Duration\", \"RR Duration\"))\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nafun &lt;- function(x, .var, .spl_context, ...) {\n  n_fun &lt;- sum(!is.na(x), na.rm = TRUE)\n  if (n_fun == 0) {\n    mean_sd_fun &lt;- c(NA, NA)\n    median_fun &lt;- NA\n    min_max_fun &lt;- c(NA, NA)\n  } else {\n    mean_sd_fun &lt;- c(mean(x, na.rm = TRUE), sd(x, na.rm = TRUE))\n    median_fun &lt;- median(x, na.rm = TRUE)\n    min_max_fun &lt;- c(min(x), max(x))\n  }\n  is_chg &lt;- .var == \"CHG\"\n  is_baseline &lt;- .spl_context$value[which(.spl_context$split == \"AVISIT\")] == \"BASELINE\"\n  if (is_baseline && is_chg) n_fun &lt;- mean_sd_fun &lt;- median_fun &lt;- min_max_fun &lt;- NULL\n\n  in_rows(\n    \"n\" = n_fun,\n    \"Mean (SD)\" = mean_sd_fun,\n    \"Median\" = median_fun,\n    \"Min - Max\" = min_max_fun,\n    .formats = list(\"n\" = \"xx\", \"Mean (SD)\" = \"xx.xx (xx.xx)\", \"Median\" = \"xx.xx\", \"Min - Max\" = \"xx.xx - xx.xx\"),\n    .format_na_strs = list(\"n\" = \"NE\", \"Mean (SD)\" = \"NE (NE)\", \"Median\" = \"NE\", \"Min - Max\" = \"NE - NE\")\n  )\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adeg_f$PARAM)) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adeg_f$AVISIT)) %&gt;%\n  split_cols_by_multivar(\n    vars = c(\"AVAL\", \"CHG\"),\n    varlabels = c(\"Value at Visit\", \"Change from\\nBaseline\")\n  ) %&gt;%\n  analyze_colvars(afun = afun)\n\nresult &lt;- build_table(lyt, adeg_f, alt_counts_df = adsl)\nresult\n\nParameter                        A: Drug X                              B: Placebo                            C: Combination            \n  Analysis Visit                         Change from                             Change from                             Change from    \n                    Value at Visit         Baseline         Value at Visit         Baseline         Value at Visit         Baseline     \n                       (N=134)             (N=134)             (N=134)             (N=134)             (N=132)             (N=132)      \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nHeart Rate                                                                                                                              \n  BASELINE                                                                                                                              \n    n                    134                                     134                                     132                            \n    Mean (SD)       71.45 (17.93)                           69.83 (20.72)                           69.34 (20.95)                       \n    Median              72.70                                   73.35                                   71.96                           \n    Min - Max       9.09 - 106.91                           13.49 - 115.52                          11.63 - 115.49                      \n  WEEK 1 DAY 8                                                                                                                          \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       70.19 (20.27)       -1.26 (25.97)       69.43 (20.80)       -0.40 (29.73)       68.65 (18.06)       -0.69 (27.81)   \n    Median              70.70               -2.20               70.46               -0.52               68.57               -0.76       \n    Min - Max       8.53 - 127.50       -50.97 - 89.16      16.85 - 129.14      -68.18 - 88.38      16.87 - 115.60      -68.25 - 67.20  \n  WEEK 2 DAY 15                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       70.32 (19.56)       -1.13 (26.26)       71.11 (20.56)        1.28 (31.35)       69.19 (18.06)       -0.15 (28.61)   \n    Median              70.88               -1.10               72.52               -0.31               69.30               -1.55       \n    Min - Max       17.14 - 116.32      -85.03 - 67.52      9.22 - 120.54       -73.07 - 81.44      29.62 - 120.50      -67.75 - 66.29  \n  WEEK 3 DAY 22                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       68.25 (20.17)       -3.20 (28.66)       68.95 (20.56)       -0.88 (30.14)       70.88 (20.28)        1.54 (27.28)   \n    Median              68.79               -2.17               67.80                1.19               70.12                0.14       \n    Min - Max       13.33 - 131.73      -81.20 - 72.57      23.98 - 130.41     -73.03 - 103.31      20.91 - 116.79      -64.51 - 72.52  \n  WEEK 4 DAY 29                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       70.06 (18.41)       -1.38 (26.59)       71.60 (20.34)        1.77 (30.26)       71.02 (20.59)        1.68 (29.60)   \n    Median              69.33               -4.54               72.21               -0.88               70.52                3.81       \n    Min - Max       22.30 - 116.51      -58.07 - 77.32      17.53 - 129.06      -64.32 - 85.34      10.35 - 117.30     -65.91 - 105.67  \n  WEEK 5 DAY 36                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       66.41 (19.74)       -5.04 (27.11)       71.25 (18.92)        1.42 (27.08)       71.26 (18.56)        1.92 (29.59)   \n    Median              65.40               -6.83               70.86                0.64               73.29                1.74       \n    Min - Max       23.89 - 110.38      -73.26 - 57.24      25.86 - 125.73      -71.15 - 67.37      23.89 - 117.19      -58.23 - 68.86  \nQT Duration                                                                                                                             \n  BASELINE                                                                                                                              \n    n                    134                                     134                                     132                            \n    Mean (SD)      336.83 (117.96)                          351.00 (98.44)                         352.60 (105.11)                      \n    Median              344.41                                  351.48                                  347.96                          \n    Min - Max       86.98 - 665.40                          98.90 - 641.92                         105.68 - 628.14                      \n  WEEK 1 DAY 8                                                                                                                          \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      342.57 (101.09)      5.74 (159.94)      363.95 (102.34)      12.94 (140.73)     359.42 (105.16)      6.83 (147.13)   \n    Median              347.26              -1.78               356.54              13.73               363.84               8.69       \n    Min - Max       91.63 - 591.42     -346.44 - 452.75    114.92 - 656.45     -317.53 - 416.35     51.91 - 611.88     -473.19 - 358.00 \n  WEEK 2 DAY 15                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       353.24 (93.93)      16.41 (162.10)      345.93 (96.78)      -5.08 (152.51)      335.69 (98.61)     -16.91 (138.45)  \n    Median              351.10              16.72               346.83              -9.68               320.96              -22.27      \n    Min - Max      138.01 - 587.30     -414.07 - 389.16    146.42 - 556.07     -440.28 - 364.76    104.91 - 562.34     -326.55 - 325.27 \n  WEEK 3 DAY 22                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      370.12 (101.57)      33.28 (152.78)     343.41 (102.58)      -7.59 (138.80)      346.95 (94.96)      -5.65 (144.65)  \n    Median              378.21              39.59               335.12              -15.89              352.15               9.11       \n    Min - Max      118.14 - 615.18     -391.72 - 520.09     63.37 - 566.51     -311.28 - 293.76    126.09 - 580.81     -412.11 - 410.01 \n  WEEK 4 DAY 29                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       345.77 (95.97)      8.94 (145.65)      354.38 (108.29)      3.37 (142.39)      341.36 (106.75)     -11.24 (145.65)  \n    Median              340.13               5.58               346.70              -17.13              352.30              -11.87      \n    Min - Max      110.12 - 616.58     -393.34 - 456.04     80.82 - 687.69     -439.90 - 364.80     4.95 - 570.61      -480.94 - 330.67 \n  WEEK 5 DAY 36                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)       358.90 (97.69)      22.07 (155.68)      338.65 (99.26)     -12.36 (130.46)      349.30 (95.77)      -3.30 (136.00)  \n    Median              351.96               5.89               344.17               0.40               350.32              12.68       \n    Min - Max       88.38 - 661.12     -353.30 - 539.84     31.25 - 563.90     -338.85 - 352.75    119.02 - 581.83     -311.45 - 295.53 \nRR Duration                                                                                                                             \n  BASELINE                                                                                                                              \n    n                    134                                     134                                     132                            \n    Mean (SD)      1028.42 (286.38)                        1027.48 (324.00)                        1074.62 (277.33)                     \n    Median             1041.86                                 1047.27                                 1080.87                          \n    Min - Max      34.33 - 1783.71                          5.29 - 1877.19                         289.60 - 1617.06                     \n  WEEK 1 DAY 8                                                                                                                          \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      990.15 (318.74)     -38.26 (446.40)     1061.59 (269.14)     34.10 (401.76)     1039.64 (284.39)    -34.98 (406.04)  \n    Median              963.88              -86.50             1061.50              66.91              1014.78              -97.83      \n    Min - Max      110.82 - 2014.56   -1014.82 - 1389.40   276.83 - 1711.99    -942.16 - 993.82    498.21 - 1937.47    -958.61 - 908.90 \n  WEEK 2 DAY 15                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      1013.37 (304.13)    -15.05 (425.81)     1109.40 (318.23)     81.92 (453.11)     1045.21 (277.51)    -29.41 (380.84)  \n    Median             1040.69              40.49              1117.76              69.27              1034.64              -15.33      \n    Min - Max      164.19 - 1677.10   -1216.10 - 1053.15   160.73 - 2048.73   -1127.10 - 1148.61   252.84 - 1722.33    -859.27 - 871.54 \n  WEEK 3 DAY 22                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      1013.99 (304.99)    -14.43 (406.53)     1118.35 (296.53)     90.86 (409.57)     1036.59 (268.52)    -38.03 (421.48)  \n    Median             1027.23              -50.54             1134.60              52.03              1030.72              -60.72      \n    Min - Max      357.04 - 1798.65   -882.94 - 1080.26    97.14 - 1825.43    -887.06 - 1166.15    446.02 - 1713.38    -984.79 - 902.37 \n  WEEK 4 DAY 29                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      1033.31 (313.92)     4.89 (483.15)      1079.76 (298.94)     52.28 (429.25)     1027.55 (295.86)    -47.07 (378.23)  \n    Median             1050.40               5.60              1051.61              69.55              1023.36              -49.52      \n    Min - Max      54.33 - 1979.43    -1345.93 - 1195.41   347.94 - 1762.04   -826.43 - 1191.83    341.62 - 2144.86   -1002.03 - 1048.66\n  WEEK 5 DAY 36                                                                                                                         \n    n                    134                 134                 134                 134                 132                 132        \n    Mean (SD)      1072.33 (282.90)     43.92 (379.05)     1058.45 (271.01)     30.97 (436.03)     1029.04 (271.21)    -45.58 (405.53)  \n    Median             1067.33              55.87              1068.95              33.61              1065.26              -34.40      \n    Min - Max      352.97 - 2000.56   -1028.79 - 1418.57   208.83 - 1794.73   -978.97 - 1365.13    436.28 - 1794.07   -962.18 - 1329.88 \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'\n    ),\n    cdisc_dataset(\"ADEG\",\n      adeg,\n      code = 'ADEG &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adeg\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"ECG Results and Change from Baseline by Visit\",\n      dataname = \"ADEG\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adeg, c(\"PARAM\", \"AVISIT\")),\n        selected = c(\"AVISIT\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adeg, c(\"AVAL\", \"CHG\")),\n        selected = c(\"AVAL\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adeg, \"PARAMCD\", \"PARAM\"),\n        selected = \"HR\"\n      ),\n      parallel_vars = TRUE\n    )\n  ),\n  filter = list(ADEG = list(AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:11:33.3826 pid:9574 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ECG/egt03.html",
+    "href": "tables/ECG/egt03.html",
+    "title": "EGT03",
+    "section": "",
+    "text": "Data Setup\nTable of Baseline Versus  Minimum Post-Baseline\nTable of Baseline Versus  Maximum Post-Baseline\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadeg &lt;- df_explicit_na(adeg)\n\nadeg_labels &lt;- var_labels(adeg)\n\nadeg_f_pbmin &lt;- subset(\n  adeg,\n  PARAMCD == \"HR\" & # Heart Rate\n    SAFFL == \"Y\" & # \"Safety Population Flag\"\n    ONTRTFL == \"Y\" & # \"On Treatment Record Flag\"\n    AVISIT == \"POST-BASELINE MINIMUM\" # \"Analysis Visit\"\n)\n\nadeg_f_pbmax &lt;- subset(\n  adeg,\n  PARAMCD == \"HR\" & # Heart Rate\n    SAFFL == \"Y\" & # \"Safety Population Flag\"\n    ONTRTFL == \"Y\" & # \"On Treatment Record Flag\"\n    AVISIT == \"POST-BASELINE MAXIMUM\" # \"Analysis Visit\"\n)\n\nvar_labels(adeg_f_pbmin) &lt;- adeg_labels\nvar_labels(adeg_f_pbmax) &lt;- adeg_labels\n\n\n\n\nFor the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purposes, missing data are added to the example dataset.\n\nCodeset.seed(123, kind = \"Mersenne-Twister\")\n\nadeg_f_pbmin$BNRIND &lt;- factor(\n  adeg_f_pbmin$BNRIND,\n  levels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\"),\n  labels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\")\n)\nadeg_f_pbmin$ANRIND &lt;- factor(\n  adeg_f_pbmin$ANRIND,\n  levels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\"),\n  labels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\")\n)\n\nadeg_f_pbmin$BNRIND[sample(1:nrow(adeg_f_pbmin), size = 5)] &lt;- \"Missing\"\nadeg_f_pbmin$ANRIND[sample(1:nrow(adeg_f_pbmin), size = 5)] &lt;- \"Missing\"\n\nattr(adeg_f_pbmin$ANRIND, \"label\") &lt;- \"Analysis Reference Range Indicator\"\nattr(adeg_f_pbmin$BNRIND, \"label\") &lt;- \"Baseline Reference Range Indicator\"\n\n# Temporary solution for overarching column\nadeg_f_pbmin &lt;- adeg_f_pbmin %&gt;% mutate(min_label = \"Minimum Post-Baseline Assessment\")\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"min_label\") %&gt;%\n  split_cols_by(\"ANRIND\") %&gt;%\n  split_rows_by(\"ARMCD\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adeg_f_pbmin$ARMCD)) %&gt;%\n  add_rowcounts() %&gt;%\n  analyze_vars(\"BNRIND\", denom = \"N_row\", .stats = \"count_fraction\") %&gt;%\n  append_varlabels(adeg_f_pbmin, c(\"BNRIND\"), indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adeg_f_pbmin\n)\n\nresult\n\nPlanned Arm Code                           Minimum Post-Baseline Assessment     \n  Baseline Reference Range Indicator      LOW         NORMAL     HIGH   Missing \n————————————————————————————————————————————————————————————————————————————————\nARM A (N=134)                                                                   \n  LOW                                   1 (0.7%)     5 (3.7%)     0        0    \n  NORMAL                               36 (26.9%)   83 (61.9%)    0     1 (0.7%)\n  HIGH                                  2 (1.5%)      4 (3%)      0        0    \n  Missing                               1 (0.7%)        0         0     1 (0.7%)\nARM B (N=134)                                                                   \n  LOW                                   1 (0.7%)     9 (6.7%)     0        0    \n  NORMAL                               40 (29.9%)    75 (56%)     0     2 (1.5%)\n  HIGH                                  1 (0.7%)      4 (3%)      0        0    \n  Missing                               1 (0.7%)     1 (0.7%)     0        0    \nARM C (N=132)                                                                   \n  LOW                                    4 (3%)     11 (8.3%)     0        0    \n  NORMAL                               31 (23.5%)   75 (56.8%)    0        0    \n  HIGH                                  1 (0.8%)     8 (6.1%)     0     1 (0.8%)\n  Missing                               1 (0.8%)        0         0        0    \n\n\n\n\nFor the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purpose, missing data are added to the example dataset.\n\nCodeset.seed(123, kind = \"Mersenne-Twister\")\n\nadeg_f_pbmax$BNRIND &lt;- factor(\n  adeg_f_pbmax$BNRIND,\n  levels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\"),\n  labels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\")\n)\nadeg_f_pbmax$ANRIND &lt;- factor(\n  adeg_f_pbmax$ANRIND,\n  levels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\"),\n  labels = c(\"LOW\", \"NORMAL\", \"HIGH\", \"Missing\")\n)\n\nadeg_f_pbmax$BNRIND[sample(1:nrow(adeg_f_pbmax), size = 5)] &lt;- \"Missing\"\nadeg_f_pbmax$ANRIND[sample(1:nrow(adeg_f_pbmax), size = 5)] &lt;- \"Missing\"\n\nattr(adeg_f_pbmax$ANRIND, \"label\") &lt;- \"Analysis Reference Range Indicator\"\nattr(adeg_f_pbmax$BNRIND, \"label\") &lt;- \"Baseline Reference Range Indicator\"\n\n# Temporary solution for overarching column\nadeg_f_pbmax &lt;- adeg_f_pbmax %&gt;% mutate(max_label = \"Maximum Post-Baseline Assessment\")\n\n# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"max_label\") %&gt;%\n  split_cols_by(\"ANRIND\") %&gt;%\n  split_rows_by(\"ARMCD\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adeg_f_pbmax$ARMCD)) %&gt;%\n  add_rowcounts() %&gt;%\n  analyze_vars(\"BNRIND\", denom = \"N_row\", .stats = \"count_fraction\") %&gt;%\n  append_varlabels(adeg_f_pbmax, c(\"BNRIND\"), indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adeg_f_pbmax\n)\n\nresult\n\nPlanned Arm Code                           Maximum Post-Baseline Assessment     \n  Baseline Reference Range Indicator   LOW      NORMAL        HIGH      Missing \n————————————————————————————————————————————————————————————————————————————————\nARM A (N=134)                                                                   \n  LOW                                   0      2 (1.5%)      4 (3%)        0    \n  NORMAL                                0     88 (65.7%)   31 (23.1%)   1 (0.7%)\n  HIGH                                  0      5 (3.7%)     1 (0.7%)       0    \n  Missing                               0         0         1 (0.7%)    1 (0.7%)\nARM B (N=134)                                                                   \n  LOW                                   0       8 (6%)      2 (1.5%)       0    \n  NORMAL                                0     76 (56.7%)   39 (29.1%)   2 (1.5%)\n  HIGH                                  0      3 (2.2%)     2 (1.5%)       0    \n  Missing                               0      1 (0.7%)     1 (0.7%)       0    \nARM C (N=132)                                                                   \n  LOW                                   0     12 (9.1%)     3 (2.3%)       0    \n  NORMAL                                0     79 (59.8%)   27 (20.5%)      0    \n  HIGH                                  0      5 (3.8%)      4 (3%)     1 (0.8%)\n  Missing                               0         0         1 (0.8%)       0    \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADEG\", adeg, code = 'ADEG &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_shift_by_arm(\n      label = \"Shift by Arm Table\",\n      dataname = \"ADEG\",\n      arm_var = choices_selected(\n        variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      paramcd = choices_selected(\n        value_choices(adeg, \"PARAMCD\"),\n        selected = \"HR\"\n      ),\n      visit_var = choices_selected(\n        value_choices(adeg, \"AVISIT\"),\n        selected = \"POST-BASELINE MINIMUM\"\n      ),\n      aval_var = choices_selected(\n        variable_choices(adeg, subset = \"ANRIND\"),\n        selected = \"ANRIND\", fixed = TRUE\n      ),\n      base_var = choices_selected(\n        variable_choices(adeg, subset = \"BNRIND\"),\n        selected = \"BNRIND\", fixed = TRUE\n      ),\n      treatment_flag_var = choices_selected(\n        variable_choices(adeg, subset = \"ONTRTFL\"),\n        selected = \"ONTRTFL\", fixed = TRUE\n      ),\n      treatment_flag = choices_selected(\n        value_choices(adeg, \"ONTRTFL\"),\n        selected = \"Y\", fixed = TRUE\n      )\n    )\n  ),\n  filter = list(ADSL = list(SAFFL = \"Y\"))\n)\n\n[INFO] 2023-09-25 11:12:53.6026 pid:9770 token:[] teal.modules.clinical Initializing tm_t_shift_by_arm\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ECG/egt04.html",
+    "href": "tables/ECG/egt04.html",
+    "title": "EGT04",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\nFor the EGT04 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purposes, missing data are added to the example dataset.\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\nset.seed(123)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadeg &lt;- synthetic_cdisc_dataset(\"latest\", \"adeg\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadeg &lt;- df_explicit_na(adeg, omit_columns = c(\"AVALC\", \"BASEC\"))\n\nadeg_labels &lt;- var_labels(adeg)\n\nadeg_f &lt;- subset(\n  adeg,\n  PARAMCD == \"ECGINTP\" & # Analysis in terms of \"NORMAL\"/\"ABNORMAL\" (AVALC)\n    SAFFL == \"Y\" & # \"Safety Population Flag\"\n    ONTRTFL == \"Y\" & # \"On Treatment Record Flag\"\n    WORS02FL == \"Y\" # \"Worst Post-Baseline Observation\"\n)\n\nadeg_f$AVALC[sample(1:nrow(adeg_f), size = 5)] &lt;- \"Missing\"\nadeg_f$BASEC[sample(1:nrow(adeg_f), size = 5)] &lt;- \"Missing\"\nadeg_f$AVALC &lt;- factor(\n  adeg_f$AVALC,\n  levels = c(\"NORMAL\", \"ABNORMAL\", \"Missing\"),\n  labels = c(\"Normal\", \"Abnormal\", \"Missing\")\n)\nadeg_f$BASEC &lt;- factor(\n  adeg_f$BASEC,\n  levels = c(\"NORMAL\", \"ABNORMAL\", \"Missing\"),\n  labels = c(\"Normal\", \"Abnormal\", \"Missing\")\n)\n\nvar_labels(adeg_f) &lt;- adeg_labels\nadeg_f &lt;- adeg_f %&gt;%\n  var_relabel(BASEC = \"Baseline\")\n\n# Temprary solution for over arching column\nadeg_f &lt;- adeg_f %&gt;% mutate(postbaseline_label = \"Post-Baseline\")\n\n\n\n\nThe EGT04 template consists of a stacked list of contingency tables, one per group. For each group, the n’s across all cells must add up to the group N in the analysis, and percentages are calculated using N as the denominator.\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table() %&gt;%\n  split_cols_by(\"postbaseline_label\") %&gt;%\n  split_cols_by(\"AVALC\") %&gt;%\n  split_rows_by(\"ARM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adeg_f$ARM)) %&gt;%\n  add_rowcounts() %&gt;%\n  analyze_vars(\n    \"BASEC\",\n    denom = \"N_row\",\n    .stats = \"count_fraction\",\n    na.rm = FALSE\n  ) %&gt;%\n  append_varlabels(adeg_f, c(\"BASEC\"), indent = 1L)\n\nresult &lt;- build_table(lyt, adeg_f)\nresult\n\nDescription of Planned Arm             Post-Baseline           \n  Baseline                     Normal      Abnormal    Missing \n———————————————————————————————————————————————————————————————\nA: Drug X (N=134)                                              \n  Normal                     20 (14.9%)   81 (60.4%)   1 (0.7%)\n  Abnormal                   11 (8.2%)    19 (14.2%)      0    \n  Missing                        0         1 (0.7%)    1 (0.7%)\nB: Placebo (N=134)                                             \n  Normal                     18 (13.4%)   81 (60.4%)   2 (1.5%)\n  Abnormal                    3 (2.2%)    28 (20.9%)      0    \n  Missing                        0         2 (1.5%)       0    \nC: Combination (N=132)                                         \n  Normal                     26 (19.7%)   69 (52.3%)   1 (0.8%)\n  Abnormal                    6 (4.5%)     29 (22%)       0    \n  Missing                     1 (0.8%)        0           0    \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet03.html",
+    "href": "tables/adverse-events/aet03.html",
+    "title": "AET03",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae) %&gt;%\n  var_relabel(\n    AEBODSYS = \"MedDRA System Organ Class\",\n    AEDECOD = \"MedDRA Preferred Term\"\n  ) %&gt;%\n  filter(ANL01FL == \"Y\")\n\n\nFor illustrative purposes, we will create a new factor variable in ADAE, ASEV, with all intensity levels including \"LIFE THREATENING\".\n\nCodeadae &lt;- adae %&gt;% mutate(ASEV = as.character(AESEV))\nadae$ASEV[1:15] &lt;- \"LIFE THREATENING\"\nadae &lt;- adae %&gt;% mutate(ASEV = factor(ASEV, levels = c(\"MILD\", \"MODERATE\", \"SEVERE\", \"LIFE THREATENING\")))\n\n\n\n\n\nCodegrade_groups &lt;- list(\"- Any Intensity -\" = c(\"MILD\", \"MODERATE\", \"SEVERE\", \"LIFE THREATENING\"))\n\nsplit_fun &lt;- trim_levels_in_group\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_occurrences_by_grade(\n    var = \"ASEV\",\n    grade_groups = grade_groups\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    split_fun = split_fun(\"ASEV\"),\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_occurrences_by_grade(\n    var = \"ASEV\",\n    grade_groups = grade_groups\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    nested = TRUE,\n    indent_mod = -1L,\n    split_fun = split_fun(\"ASEV\"),\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEDECOD)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = c(\"- Any Intensity -\")\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"ASEV\",\n    .indent_mods = -1L\n  ) %&gt;%\n  append_varlabels(adae, \"AESEV\", indent = 2L)\n\nresult &lt;- lyt %&gt;%\n  build_table(\n    adae,\n    alt_counts_df = adsl\n  ) %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = cont_n_allcols,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = cont_n_allcols,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                            \n  MedDRA Preferred Term      A: Drug X    B: Placebo   C: Combination\n    Severity/Intensity        (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————\n- Any Intensity -           100 (74.6%)   98 (73.1%)    103 (78.0%)  \nMILD                         5 (3.7%)      7 (5.2%)       4 (3.0%)   \nMODERATE                    17 (12.7%)    21 (15.7%)     20 (15.2%)  \nSEVERE                      77 (57.5%)    69 (51.5%)     77 (58.3%)  \nLIFE THREATENING             1 (0.7%)      1 (0.7%)       2 (1.5%)   \ncl A.1                                                               \n  - Any Intensity -         68 (50.7%)    58 (43.3%)     76 (57.6%)  \n  MILD                      27 (20.1%)    19 (14.2%)     34 (25.8%)  \n  MODERATE                  40 (29.9%)    39 (29.1%)     41 (31.1%)  \n  LIFE THREATENING           1 (0.7%)         0           1 (0.8%)   \n  dcd A.1.1.1.1                                                      \n    - Any Intensity -       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n    MILD                    45 (33.6%)    31 (23.1%)     51 (38.6%)  \n    LIFE THREATENING             0            0           1 (0.8%)   \n  dcd A.1.1.1.2                                                      \n    - Any Intensity -       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n    MODERATE                40 (29.9%)    39 (29.1%)     41 (31.1%)  \n    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   \ncl B.2                                                               \n  - Any Intensity -         62 (46.3%)    56 (41.8%)     74 (56.1%)  \n  MILD                      23 (17.2%)    22 (16.4%)     28 (21.2%)  \n  MODERATE                  38 (28.4%)    34 (25.4%)     45 (34.1%)  \n  LIFE THREATENING           1 (0.7%)         0           1 (0.8%)   \n  dcd B.2.2.3.1                                                      \n    - Any Intensity -       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n    MILD                    38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                      \n    - Any Intensity -       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n    MODERATE                38 (28.4%)    34 (25.4%)     45 (34.1%)  \n    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   \ncl D.1                                                               \n  - Any Intensity -         64 (47.8%)    54 (40.3%)     68 (51.5%)  \n  MODERATE                  21 (15.7%)    22 (16.4%)     22 (16.7%)  \n  SEVERE                    42 (31.3%)    32 (23.9%)     44 (33.3%)  \n  LIFE THREATENING           1 (0.7%)         0           2 (1.5%)   \n  dcd D.1.1.1.1                                                      \n    - Any Intensity -       42 (31.3%)    32 (23.9%)     46 (34.8%)  \n    SEVERE                  42 (31.3%)    32 (23.9%)     45 (34.1%)  \n    LIFE THREATENING             0            0           1 (0.8%)   \n  dcd D.1.1.4.2                                                      \n    - Any Intensity -       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n    MODERATE                37 (27.6%)    34 (25.4%)     39 (29.5%)  \n    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   \ncl D.2                                                               \n  - Any Intensity -         37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  MILD                      37 (27.6%)    46 (34.3%)     49 (37.1%)  \n  LIFE THREATENING               0            0           1 (0.8%)   \n  dcd D.2.1.5.3                                                      \n    - Any Intensity -       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n    MILD                    37 (27.6%)    46 (34.3%)     49 (37.1%)  \n    LIFE THREATENING             0            0           1 (0.8%)   \ncl C.2                                                               \n  - Any Intensity -         28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  MODERATE                  28 (20.9%)    36 (26.9%)     47 (35.6%)  \n  LIFE THREATENING               0            0           1 (0.8%)   \n  dcd C.2.1.2.1                                                      \n    - Any Intensity -       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n    MODERATE                28 (20.9%)    36 (26.9%)     47 (35.6%)  \n    LIFE THREATENING             0            0           1 (0.8%)   \ncl B.1                                                               \n  - Any Intensity -         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  SEVERE                    38 (28.4%)    36 (26.9%)     36 (27.3%)  \n  LIFE THREATENING               0         1 (0.7%)          0       \n  dcd B.1.1.1.1                                                      \n    - Any Intensity -       38 (28.4%)    37 (27.6%)     36 (27.3%)  \n    SEVERE                  38 (28.4%)    36 (26.9%)     36 (27.3%)  \n    LIFE THREATENING             0         1 (0.7%)          0       \ncl C.1                                                               \n  - Any Intensity -         36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  SEVERE                    36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                      \n    - Any Intensity -       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n    SEVERE                  36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADAE\", adae),\n    code =\n      'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n      ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_by_grade(\n      label = \"Adverse Events by Grade Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = \"AEBODSYS\"\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adae, c(\"AETOXGR\", \"AESEV\")),\n        selected = \"AESEV\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:14:49.0451 pid:10115 token:[] teal.modules.clinical Initializing tm_t_events_by_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet07.html",
+    "href": "tables/adverse-events/aet07.html",
+    "title": "AET07",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Fill-In of Treatment Groups without Deaths\nteal App\nReproducibility\n\n\n\nFor illustrative purposes, we will pre-process AESDTH in ADAE so there are no deaths in arm A and concatenate AEBODSYS and AEDECOD as per GDSR output standards for AET07.\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nadae_f &lt;- adae %&gt;%\n  mutate(\n    AESDTH = as.character(AESDTH), # characterizing AESDTH for next step\n    AESDTH = case_when(\n      ARM == \"A: Drug X\" ~ NA_character_, # For demonstration purpose only,\n      TRUE ~ AESDTH\n    ), # make \"A: Drug X\" as the arm without AE leading to death\n    AESDTH = as.factor(AESDTH),\n    SOC_PT = factor(paste(AEBODSYS, \"/\", AEDECOD))\n  ) %&gt;%\n  filter(AESDTH == \"Y\") %&gt;%\n  mutate(ARM = droplevels(ARM))\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\", split_fun = drop_split_levels) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = c(unique = \"Total number of deaths\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"SOC_PT\"\n  ) %&gt;%\n  append_topleft(\"MedDRA SOC and Preferred Term\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae_f,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"SOC_PT\",\n    scorefun = score_occurrences,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA SOC and Preferred Term   B: Placebo   C: Combination\n                                 (N=134)        (N=132)    \n———————————————————————————————————————————————————————————\nTotal number of deaths          70 (52.2%)     75 (56.8%)  \ncl D.1 / dcd D.1.1.1.1          42 (31.3%)     51 (38.6%)  \ncl B.1 / dcd B.1.1.1.1          49 (36.6%)     43 (32.6%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = c(unique = \"Total number of deaths\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"SOC_PT\"\n  ) %&gt;%\n  append_topleft(\"MedDRA SOC and Preferred Term\")\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae_f,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"SOC_PT\",\n    scorefun = score_occurrences,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA SOC and Preferred Term   A: Drug X   B: Placebo   C: Combination\n                                 (N=134)     (N=134)        (N=132)    \n———————————————————————————————————————————————————————————————————————\nTotal number of deaths              0       70 (52.2%)     75 (56.8%)  \ncl D.1 / dcd D.1.1.1.1              0       42 (31.3%)     51 (38.6%)  \ncl B.1 / dcd B.1.1.1.1              0       49 (36.6%)     43 (32.6%)  \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nadsl &lt;- adsl %&gt;%\n  mutate(\n    DTHFL = case_when(\n      !is.na(DTHDT) ~ \"Y\",\n      TRUE ~ \"\"\n    )\n  ) %&gt;%\n  var_relabel(\n    DTHFL = \"Subject Death Flag\"\n  )\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AESDTH = as.character(AESDTH), # characterizing AESDTH for next step\n    AESDTH = case_when(\n      ARM == \"A: Drug X\" ~ NA_character_, # For demonstration purpose only,\n      TRUE ~ AESDTH\n    ), # make \"A: Drug X\" as the arm without AE leading to death\n    AESDTH = as.factor(AESDTH),\n    SOC_PT = factor(paste(AEBODSYS, \"/\", AEDECOD))\n  ) %&gt;%\n  filter(AESDTH == \"Y\") %&gt;%\n  mutate(ARM = droplevels(ARM)) %&gt;%\n  var_relabel(SOC_PT = \"MedDRA SOC and Preferred Term\")\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = '\n                  ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;%\n                    df_explicit_na() %&gt;%\n                    mutate(\n                      DTHFL = case_when(\n                        !is.na(DTHDT) ~ \"Y\",\n                        TRUE ~ \"\"\n                      )\n                    ) %&gt;%\n                    var_relabel(\n                      DTHFL = \"Subject Death Flag\"\n                    )\n                  '),\n    cdisc_dataset(\"ADAE\", adae, code = '\n                  ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\") %&gt;%\n                    df_explicit_na() %&gt;%\n                    mutate(\n                      AESDTH = as.character(AESDTH),\n                      AESDTH = case_when(\n                        ARM == \"A: Drug X\" ~ NA_character_,\n                        TRUE ~ AESDTH),\n                      AESDTH = as.factor(AESDTH),\n                      SOC_PT = factor(paste(AEBODSYS, \"/\", AEDECOD))\n                    ) %&gt;%\n                    filter(AESDTH == \"Y\") %&gt;%\n                    mutate(ARM = droplevels(ARM)) %&gt;%\n                    var_relabel(SOC_PT = \"MedDRA SOC and Preferred Term\")\n                  '),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Adverse Event Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\", \"SOC_PT\")),\n        selected = c(\"SOC_PT\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\", \"SOC_PT\")),\n        selected = NULL\n      ),\n      add_total = FALSE,\n      event_type = \"adverse event\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:16:06.0733 pid:10311 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet09_smq.html",
+    "href": "tables/adverse-events/aet09_smq.html",
+    "title": "AET09_SMQ",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Customized Queries\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(stringr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing\n# levels. For details, refer to Teal and Study Data article.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\n# AEs are filtered for relatedness to study drug.\nadae_rel &lt;- adae %&gt;% filter(AEREL == \"Y\")\n\n# Simulate a random AAG dataset.\naag &lt;- data.frame(\n  NAMVAR = c(\"SMQ01NAM\", \"SMQ01NAM\", \"SMQ02NAM\", \"CQ01NAM\", \"CQ01NAM\"),\n  SRCVAR = rep(\"AEDECOD\", 5),\n  GRPTYPE = c(\"SMQ\", \"SMQ\", \"SMQ\", \"CUSTOM\", \"CUSTOM\"),\n  REFID = c(1, 1, 2, 3, 3),\n  REFNAME = c(rep(\"C.1.1.1.3/B.2.2.3.1 AESI\", 2), \"non observed SMQ02NAM level\", rep(\"D.2.1.5.3/A.1.1.1.1 AESI\", 2)),\n  SCOPE = c(\"BROAD\", \"BROAD\", \"BROAD\", \"\", \"\"),\n  REFTERM = c(\"C.1.1.1.3\", \"B.2.2.3.1\", \"Z.9.9.9.9\", \"D.2.1.5.3\", \"A.1.1.1.1\"),\n  stringsAsFactors = FALSE\n)\n\n# Create summary AAG dataset (used for labelling).\n# Note it's important to incorporate SCOPE into the basket names for SMQs so as to\n# match the flags present in ADAE.\naag_summary &lt;- aag %&gt;%\n  select(NAMVAR, REFNAME, SCOPE) %&gt;%\n  unique() %&gt;%\n  mutate(\n    REFNAME_SCOPE = ifelse(SCOPE == \"\", REFNAME, paste0(REFNAME, \"(\", SCOPE, \")\"))\n  ) %&gt;%\n  rename(basket = NAMVAR, basket_name = REFNAME_SCOPE) %&gt;%\n  select(basket, basket_name)\n\n# Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function\nadae_smq_all &lt;- h_stack_by_baskets(df = adae_rel, aag_summary = aag_summary, keys = c(\"STUDYID\", \"USUBJID\", \"ACTARMCD\", \"AEDECOD\"))\n\n# Post-process adae_smq_all to keep only certain baskets of interest for variant 1\n# Not need to drop baskets for variant 2 as all baskets will be considered.\nbaskets_to_drop_variant &lt;- aag_summary$basket_name[!aag_summary$basket %in% c(\"SMQ01NAM\")]\n\n# Adjust the analysis dataset based on basket subset for variant 1.\nadae_smq_1 &lt;- adae_smq_all %&gt;%\n  filter(!adae_smq_all$SMQ %in% baskets_to_drop_variant) %&gt;%\n  mutate(\n    SMQ = tern::fct_discard(SMQ, discard = baskets_to_drop_variant)\n  )\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) !is(tr, \"ContentRow\") && all_zero_or_na(tr)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = -1L,\n    drop = FALSE\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt,\n  df = adae_smq_1,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = cont_n_allcols) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                      ARM A        ARM B        ARM C   \n  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  \n—————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     43 (32.1%)   46 (34.3%)   43 (32.6%)\nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  \n  Total number of patients with at least one adverse event   43 (32.1%)   46 (34.3%)   43 (32.6%)\n  Total number of events                                         55           63           64    \n  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) {\n  !is(tr, \"ContentRow\") && all_zero_or_na(tr) && !grepl(\"Total number of\", obj_label(tr))\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    ),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    drop = FALSE\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nscore_ae_pts &lt;- function(tt) {\n  count_vals &lt;- cell_values(tree_children(tt)[[\"USUBJID\"]])[[1]]\n  sum(matrix(unlist(count_vals), nrow = length(count_vals), byrow = TRUE)[, 1])\n}\n\nresult &lt;- build_table(\n  lyt,\n  df = adae_smq_all,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = score_ae_pts) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                      ARM A        ARM B        ARM C   \n  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  \n—————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     69 (51.5%)   78 (58.2%)   77 (58.3%)\nD.2.1.5.3/A.1.1.1.1 AESI                                                                         \n  Total number of patients with at least one adverse event   47 (35.1%)   58 (43.3%)   57 (43.2%)\n  Total number of events                                         62           72           74    \n  dcd D.2.1.5.3                                              47 (35.1%)   58 (43.3%)   57 (43.2%)\nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  \n  Total number of patients with at least one adverse event   43 (32.1%)   46 (34.3%)   43 (32.6%)\n  Total number of events                                         55           63           64    \n  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)\nnon observed SMQ02NAM level(BROAD)                                                               \n  Total number of patients with at least one adverse event       0            0            0     \n  Total number of events                                         0            0            0     \n\n\n\n\nNote that filtering AEs for relatedness to study drug is not a necessary data pre-processing step for the module. It can be achieved using the teal module filter panel. The example here pre-sets the filters using AEREL = \"Y\" in adae.\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nnames_baskets &lt;- grep(\"^(SMQ|CQ).*NAM$\", names(adae), value = TRUE)\nnames_scopes &lt;- grep(\"^SMQ.*SC$\", names(adae), value = TRUE)\n\ncs_baskets &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_baskets),\n  selected = names_baskets\n)\ncs_scopes &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_scopes),\n  selected = names_scopes,\n  fixed = TRUE\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'\n    ),\n    cdisc_dataset(\"ADAE\", adae,\n      code = 'ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_smq(\n      label = \"Adverse Events by SMQ Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"SEX\")),\n        selected = \"ARM\"\n      ),\n      add_total = FALSE,\n      baskets = cs_baskets,\n      scopes = cs_scopes,\n      llt = choices_selected(\n        choices = variable_choices(adae, subset = c(\"AEDECOD\")),\n        selected = \"AEDECOD\"\n      )\n    )\n  ),\n  filter = list(ADAE = list(AEREL = \"Y\"))\n)\n\n[INFO] 2023-09-25 11:17:09.7388 pid:10507 token:[] teal.modules.clinical Initializing tm_t_smq\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] stringr_1.5.0                scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          \n[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         \n[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      \n[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           \n[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[85] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet06.html",
+    "href": "tables/adverse-events/aet06.html",
+    "title": "AET06",
+    "section": "",
+    "text": "Data Setup\nAdverse Events by Sex\nAdverse Events by Other Baseline  Characteristics (e.g. Biomarker Group)\nAdverse Events by Baseline Characteristic  from ADSUB (e.g. BMI Category)\nAdverse Events by Regrouped Baseline  Characteristics (e.g. Race)\nAdverse Events by Baseline Characteristics  (e.g. Sex) Including High-Level Terms\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\nadsub &lt;- synthetic_cdisc_dataset(\"latest\", \"adsub\")\n\nadsub_bmi &lt;- adsub %&gt;%\n  filter(PARAMCD == \"BBMISI\") %&gt;%\n  select(STUDYID, USUBJID, AVALCAT1) %&gt;%\n  mutate(\n    AVALCAT1 = factor(AVALCAT1, levels = c(\"&lt;18.5\", \"18.5 - 24.9\", \"25 - 29.9\", \"&gt;30\"))\n  )\n\nadsl &lt;- adsl %&gt;%\n  mutate(\n    RACE1 = case_when(\n      RACE == \"WHITE\" ~ \"WHITE\",\n      TRUE ~ \"NON-WHITE\"\n    ),\n    RACE1 = factor(\n      RACE1,\n      levels = c(\"WHITE\", \"NON-WHITE\")\n    )\n  ) %&gt;%\n  left_join(\n    y = adsub_bmi,\n    by = c(\"STUDYID\", \"USUBJID\")\n  )\n\nadae_labels &lt;- var_labels(adae)\n\nadae &lt;- adae %&gt;%\n  mutate(\n    RACE1 = case_when(\n      RACE == \"WHITE\" ~ \"WHITE\",\n      TRUE ~ \"NON-WHITE\"\n    ),\n    RACE1 = factor(\n      RACE1,\n      levels = c(\"WHITE\", \"NON-WHITE\")\n    )\n  ) %&gt;%\n  left_join(\n    y = adsub_bmi,\n    by = c(\"STUDYID\", \"USUBJID\")\n  )\n\nvar_labels(adae) &lt;- c(adae_labels, \"RACE1\" = \"RACE WHITE/NON-WHITE\", \"AVALCAT1\" = \"Baseline BMI Category\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\nadsub_bmi &lt;- df_explicit_na(adsub_bmi)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"SEX\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                          A: Drug X                B: Placebo              C: Combination     \n  Dictionary-Derived Term                                        F            M            F            M            F            M     \n                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     72 (91.1%)   50 (90.9%)   77 (93.9%)   46 (88.5%)   65 (92.9%)   55 (88.7%)\nOverall total number of events                                  377          232          419          203          378          325    \ncl A.1                                                                                                                                  \n  Total number of patients with at least one adverse event   53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)\n  Total number of events                                         85           47           93           37           86           74    \n  dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)\n  dcd A.1.1.1.2                                              32 (40.5%)   16 (29.1%)   33 (40.2%)   15 (28.8%)   24 (34.3%)   26 (41.9%)\ncl B.2                                                                                                                                  \n  Total number of patients with at least one adverse event   46 (58.2%)   33 (60.0%)   45 (54.9%)   29 (55.8%)   44 (62.9%)   41 (66.1%)\n  Total number of events                                         81           48           86           52           64           79    \n  dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)\n  dcd B.2.1.2.1                                              29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)\ncl D.1                                                                                                                                  \n  Total number of patients with at least one adverse event   45 (57.0%)   34 (61.8%)   40 (48.8%)   27 (51.9%)   41 (58.6%)   39 (62.9%)\n  Total number of events                                         72           55           64           42           73           62    \n  dcd D.1.1.1.1                                              25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)\n  dcd D.1.1.4.2                                              30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)\ncl D.2                                                                                                                                  \n  Total number of patients with at least one adverse event   26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\n  Total number of events                                         35           27           49           23           43           31    \n  dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\ncl B.1                                                                                                                                  \n  Total number of patients with at least one adverse event   28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)\n  Total number of events                                         33           23           36           24           35           27    \n  dcd B.1.1.1.1                                              28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)\ncl C.2                                                                                                                                  \n  Total number of patients with at least one adverse event   23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)\n  Total number of events                                         32           16           39           14           33           32    \n  dcd C.2.1.2.1                                              23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)\ncl C.1                                                                                                                                  \n  Total number of patients with at least one adverse event   30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n  Total number of events                                         39           16           52           11           44           20    \n  dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"BMRKR2\") %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                                A: Drug X                              B: Placebo                           C: Combination           \n  Dictionary-Derived Term                                       LOW         MEDIUM        HIGH         LOW         MEDIUM        HIGH         LOW         MEDIUM        HIGH   \n                                                               (N=50)       (N=37)       (N=47)       (N=45)       (N=56)       (N=33)       (N=40)       (N=42)       (N=50)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     46 (92.0%)   34 (91.9%)   42 (89.4%)   40 (88.9%)   53 (94.6%)   30 (90.9%)   36 (90.0%)   39 (92.9%)   45 (90.0%)\nOverall total number of events                                  248          166          195          196          261          165          220          258          225    \ncl A.1                                                                                                                                                                         \n  Total number of patients with at least one adverse event   31 (62.0%)   19 (51.4%)   28 (59.6%)   25 (55.6%)   31 (55.4%)   19 (57.6%)   28 (70.0%)   30 (71.4%)   31 (62.0%)\n  Total number of events                                         53           34           45           46           54           30           61           51           48    \n  dcd A.1.1.1.1                                              22 (44.0%)   10 (27.0%)   18 (38.3%)   14 (31.1%)   20 (35.7%)   11 (33.3%)   21 (52.5%)   24 (57.1%)   18 (36.0%)\n  dcd A.1.1.1.2                                              17 (34.0%)   13 (35.1%)   18 (38.3%)   18 (40.0%)   18 (32.1%)   12 (36.4%)   18 (45.0%)   14 (33.3%)   18 (36.0%)\ncl B.2                                                                                                                                                                         \n  Total number of patients with at least one adverse event   34 (68.0%)   21 (56.8%)   24 (51.1%)   23 (51.1%)   33 (58.9%)   18 (54.5%)   24 (60.0%)   27 (64.3%)   34 (68.0%)\n  Total number of events                                         53           37           39           40           61           37           40           47           56    \n  dcd B.2.2.3.1                                              21 (42.0%)   13 (35.1%)   14 (29.8%)   18 (40.0%)   22 (39.3%)   14 (42.4%)   16 (40.0%)   15 (35.7%)   20 (40.0%)\n  dcd B.2.1.2.1                                              21 (42.0%)   11 (29.7%)   17 (36.2%)   11 (24.4%)   21 (37.5%)   12 (36.4%)   13 (32.5%)   17 (40.5%)   22 (44.0%)\ncl D.1                                                                                                                                                                         \n  Total number of patients with at least one adverse event   34 (68.0%)   21 (56.8%)   24 (51.1%)   18 (40.0%)   33 (58.9%)   16 (48.5%)   25 (62.5%)   31 (73.8%)   24 (48.0%)\n  Total number of events                                         51           35           41           27           49           30           45           53           37    \n  dcd D.1.1.1.1                                              19 (38.0%)   16 (43.2%)   15 (31.9%)   13 (28.9%)   19 (33.9%)   10 (30.3%)   14 (35.0%)   22 (52.4%)   15 (30.0%)\n  dcd D.1.1.4.2                                              21 (42.0%)   9 (24.3%)    18 (38.3%)   9 (20.0%)    20 (35.7%)   13 (39.4%)   17 (42.5%)   18 (42.9%)   15 (30.0%)\ncl D.2                                                                                                                                                                         \n  Total number of patients with at least one adverse event   20 (40.0%)   12 (32.4%)   15 (31.9%)   19 (42.2%)   22 (39.3%)   17 (51.5%)   13 (32.5%)   23 (54.8%)   21 (42.0%)\n  Total number of events                                         27           13           22           23           26           23           17           33           24    \n  dcd D.2.1.5.3                                              20 (40.0%)   12 (32.4%)   15 (31.9%)   19 (42.2%)   22 (39.3%)   17 (51.5%)   13 (32.5%)   23 (54.8%)   21 (42.0%)\ncl B.1                                                                                                                                                                         \n  Total number of patients with at least one adverse event   14 (28.0%)   14 (37.8%)   19 (40.4%)   15 (33.3%)   24 (42.9%)   10 (30.3%)   14 (35.0%)   15 (35.7%)   14 (28.0%)\n  Total number of events                                         16           19           21           18           25           17           19           25           18    \n  dcd B.1.1.1.1                                              14 (28.0%)   14 (37.8%)   19 (40.4%)   15 (33.3%)   24 (42.9%)   10 (30.3%)   14 (35.0%)   15 (35.7%)   14 (28.0%)\ncl C.2                                                                                                                                                                         \n  Total number of patients with at least one adverse event   18 (36.0%)   8 (21.6%)    9 (19.1%)    15 (33.3%)   22 (39.3%)   11 (33.3%)   18 (45.0%)   17 (40.5%)   20 (40.0%)\n  Total number of events                                         27           9            12           18           23           12           20           20           25    \n  dcd C.2.1.2.1                                              18 (36.0%)   8 (21.6%)    9 (19.1%)    15 (33.3%)   22 (39.3%)   11 (33.3%)   18 (45.0%)   17 (40.5%)   20 (40.0%)\ncl C.1                                                                                                                                                                         \n  Total number of patients with at least one adverse event   17 (34.0%)   14 (37.8%)   12 (25.5%)   17 (37.8%)   17 (30.4%)   12 (36.4%)   12 (30.0%)   17 (40.5%)   14 (28.0%)\n  Total number of events                                         21           19           15           24           23           16           18           29           17    \n  dcd C.1.1.1.3                                              17 (34.0%)   14 (37.8%)   12 (25.5%)   17 (37.8%)   17 (30.4%)   12 (36.4%)   12 (30.0%)   17 (40.5%)   14 (28.0%)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"AVALCAT1\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                                       A: Drug X                                          B: Placebo                                         C: Combination                  \n  Dictionary-Derived Term                                      &lt;18.5      18.5 - 24.9   25 - 29.9      &gt;30         &lt;18.5      18.5 - 24.9   25 - 29.9      &gt;30         &lt;18.5      18.5 - 24.9   25 - 29.9       &gt;30    \n                                                               (N=44)       (N=17)       (N=11)       (N=62)       (N=37)       (N=18)       (N=10)       (N=69)       (N=28)       (N=20)        (N=18)       (N=66)  \n———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     41 (93.2%)   14 (82.4%)    11 (100%)   56 (90.3%)   35 (94.6%)   16 (88.9%)    9 (90.0%)   63 (91.3%)   25 (89.3%)   19 (95.0%)    15 (83.3%)   61 (92.4%)\nOverall total number of events                                  186           80           66          277          174           89           47          312          137           129          100          337    \ncl A.1                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   23 (52.3%)   12 (70.6%)    7 (63.6%)   36 (58.1%)   19 (51.4%)   10 (55.6%)    6 (60.0%)   40 (58.0%)   16 (57.1%)   13 (65.0%)    14 (77.8%)   46 (69.7%)\n  Total number of events                                         38           22           13           59           35           22            6           67           30           23            30           77    \n  dcd A.1.1.1.1                                              14 (31.8%)    7 (41.2%)    3 (27.3%)   26 (41.9%)   12 (32.4%)    6 (33.3%)    4 (40.0%)   23 (33.3%)   12 (42.9%)    7 (35.0%)    13 (72.2%)   31 (47.0%)\n  dcd A.1.1.1.2                                              15 (34.1%)    8 (47.1%)    5 (45.5%)   20 (32.3%)   12 (32.4%)    8 (44.4%)    2 (20.0%)   26 (37.7%)   9 (32.1%)     7 (35.0%)    7 (38.9%)    27 (40.9%)\ncl B.2                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   23 (52.3%)   10 (58.8%)    8 (72.7%)   38 (61.3%)   21 (56.8%)    8 (44.4%)    7 (70.0%)   38 (55.1%)   16 (57.1%)   16 (80.0%)    12 (66.7%)   41 (62.1%)\n  Total number of events                                         37           19           12           61           41           18           12           67           28           28            18           69    \n  dcd B.2.2.3.1                                              13 (29.5%)    7 (41.2%)    6 (54.5%)   22 (35.5%)   14 (37.8%)    7 (38.9%)    6 (60.0%)   27 (39.1%)   7 (25.0%)    13 (65.0%)    5 (27.8%)    26 (39.4%)\n  dcd B.2.1.2.1                                              14 (31.8%)    8 (47.1%)    4 (36.4%)   23 (37.1%)   14 (37.8%)    6 (33.3%)    4 (40.0%)   20 (29.0%)   13 (46.4%)    8 (40.0%)    8 (44.4%)    23 (34.8%)\ncl D.1                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   24 (54.5%)    9 (52.9%)    8 (72.7%)   38 (61.3%)   18 (48.6%)    5 (27.8%)    7 (70.0%)   37 (53.6%)   15 (53.6%)   12 (60.0%)    11 (61.1%)   42 (63.6%)\n  Total number of events                                         38           11           17           61           30           11           14           51           30           23            16           66    \n  dcd D.1.1.1.1                                              13 (29.5%)    7 (41.2%)    7 (63.6%)   23 (37.1%)   13 (35.1%)    3 (16.7%)    4 (40.0%)   22 (31.9%)   12 (42.9%)    6 (30.0%)    8 (44.4%)    25 (37.9%)\n  dcd D.1.1.4.2                                              16 (36.4%)    4 (23.5%)    6 (54.5%)   22 (35.5%)   10 (27.0%)    4 (22.2%)    5 (50.0%)   23 (33.3%)   10 (35.7%)    9 (45.0%)    6 (33.3%)    25 (37.9%)\ncl D.2                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   14 (31.8%)    7 (41.2%)    5 (45.5%)   21 (33.9%)   14 (37.8%)   10 (55.6%)    4 (40.0%)   30 (43.5%)   13 (46.4%)   10 (50.0%)    7 (38.9%)    27 (40.9%)\n  Total number of events                                         20            7           10           25           17           14            5           36           18           15            10           31    \n  dcd D.2.1.5.3                                              14 (31.8%)    7 (41.2%)    5 (45.5%)   21 (33.9%)   14 (37.8%)   10 (55.6%)    4 (40.0%)   30 (43.5%)   13 (46.4%)   10 (50.0%)    7 (38.9%)    27 (40.9%)\ncl B.1                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   17 (38.6%)    5 (29.4%)    7 (63.6%)   18 (29.0%)   14 (37.8%)    8 (44.4%)    4 (40.0%)   23 (33.3%)   7 (25.0%)    10 (50.0%)    7 (38.9%)    19 (28.8%)\n  Total number of events                                         22            5            7           22           16           11            4           29           11           12            8            31    \n  dcd B.1.1.1.1                                              17 (38.6%)    5 (29.4%)    7 (63.6%)   18 (29.0%)   14 (37.8%)    8 (44.4%)    4 (40.0%)   23 (33.3%)   7 (25.0%)    10 (50.0%)    7 (38.9%)    19 (28.8%)\ncl C.2                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   14 (31.8%)    4 (23.5%)    2 (18.2%)   15 (24.2%)   15 (40.5%)    5 (27.8%)    4 (40.0%)   24 (34.8%)   10 (35.7%)   13 (65.0%)    8 (44.4%)    24 (36.4%)\n  Total number of events                                         17            9            3           19           15            6            5           27           12           16            9            28    \n  dcd C.2.1.2.1                                              14 (31.8%)    4 (23.5%)    2 (18.2%)   15 (24.2%)   15 (40.5%)    5 (27.8%)    4 (40.0%)   24 (34.8%)   10 (35.7%)   13 (65.0%)    8 (44.4%)    24 (36.4%)\ncl C.1                                                                                                                                                                                                                 \n  Total number of patients with at least one adverse event   11 (25.0%)    4 (23.5%)    4 (36.4%)   24 (38.7%)   13 (35.1%)    6 (33.3%)    1 (10.0%)   26 (37.7%)   6 (21.4%)     7 (35.0%)    6 (33.3%)    24 (36.4%)\n  Total number of events                                         14            7            4           30           20            7            1           35           8            12            9            35    \n  dcd C.1.1.1.3                                              11 (25.0%)    4 (23.5%)    4 (36.4%)   24 (38.7%)   13 (35.1%)    6 (33.3%)    1 (10.0%)   26 (37.7%)   6 (21.4%)     7 (35.0%)    6 (33.3%)    24 (36.4%)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"RACE1\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(vars = \"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  prune_table() %&gt;%\n  # Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                          A: Drug X                B: Placebo              C: Combination     \n  Dictionary-Derived Term                                      WHITE      NON-WHITE      WHITE      NON-WHITE      WHITE      NON-WHITE \n                                                               (N=27)      (N=107)       (N=26)      (N=108)       (N=21)      (N=111)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     26 (96.3%)   96 (89.7%)   25 (96.2%)   98 (90.7%)   21 (100%)    99 (89.2%)\nOverall total number of events                                  109          500          144          478          114          589    \ncl A.1                                                                                                                                  \n  Total number of patients with at least one adverse event   16 (59.3%)   62 (57.9%)   21 (80.8%)   54 (50.0%)   15 (71.4%)   74 (66.7%)\n  Total number of events                                         30          102           37           93           25          135    \n  dcd A.1.1.1.1                                              9 (33.3%)    41 (38.3%)   14 (53.8%)   31 (28.7%)   10 (47.6%)   53 (47.7%)\n  dcd A.1.1.1.2                                              11 (40.7%)   37 (34.6%)   13 (50.0%)   35 (32.4%)   9 (42.9%)    41 (36.9%)\ncl B.2                                                                                                                                  \n  Total number of patients with at least one adverse event   15 (55.6%)   64 (59.8%)   16 (61.5%)   58 (53.7%)   12 (57.1%)   73 (65.8%)\n  Total number of events                                         18          111           28          110           17          126    \n  dcd B.2.2.3.1                                              4 (14.8%)    44 (41.1%)   10 (38.5%)   44 (40.7%)   5 (23.8%)    46 (41.4%)\n  dcd B.2.1.2.1                                              12 (44.4%)   37 (34.6%)   9 (34.6%)    35 (32.4%)   7 (33.3%)    45 (40.5%)\ncl D.1                                                                                                                                  \n  Total number of patients with at least one adverse event   18 (66.7%)   61 (57.0%)   15 (57.7%)   52 (48.1%)   14 (66.7%)   66 (59.5%)\n  Total number of events                                         27          100           23           83           27          108    \n  dcd D.1.1.1.1                                              11 (40.7%)   39 (36.4%)   14 (53.8%)   28 (25.9%)   12 (57.1%)   39 (35.1%)\n  dcd D.1.1.4.2                                              11 (40.7%)   37 (34.6%)   7 (26.9%)    35 (32.4%)   9 (42.9%)    41 (36.9%)\ncl D.2                                                                                                                                  \n  Total number of patients with at least one adverse event   6 (22.2%)    41 (38.3%)   15 (57.7%)   43 (39.8%)   9 (42.9%)    48 (43.2%)\n  Total number of events                                         6            56           18           54           12           62    \n  dcd D.2.1.5.3                                              6 (22.2%)    41 (38.3%)   15 (57.7%)   43 (39.8%)   9 (42.9%)    48 (43.2%)\ncl B.1                                                                                                                                  \n  Total number of patients with at least one adverse event   12 (44.4%)   35 (32.7%)   7 (26.9%)    42 (38.9%)   6 (28.6%)    37 (33.3%)\n  Total number of events                                         15           41           8            52           8            54    \n  dcd B.1.1.1.1                                              12 (44.4%)   35 (32.7%)   7 (26.9%)    42 (38.9%)   6 (28.6%)    37 (33.3%)\ncl C.2                                                                                                                                  \n  Total number of patients with at least one adverse event   5 (18.5%)    30 (28.0%)   11 (42.3%)   37 (34.3%)   11 (52.4%)   44 (39.6%)\n  Total number of events                                         8            40           12           41           12           53    \n  dcd C.2.1.2.1                                              5 (18.5%)    30 (28.0%)   11 (42.3%)   37 (34.3%)   11 (52.4%)   44 (39.6%)\ncl C.1                                                                                                                                  \n  Total number of patients with at least one adverse event   5 (18.5%)    38 (35.5%)   13 (50.0%)   33 (30.6%)   8 (38.1%)    35 (31.5%)\n  Total number of events                                         5            50           18           45           13           51    \n  dcd C.1.1.1.3                                              5 (18.5%)    38 (35.5%)   13 (50.0%)   33 (30.6%)   8 (38.1%)    35 (31.5%)\n\n\n\n\n\nCodesplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  split_cols_by(\"SEX\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Overall total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEBODSYS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"AEHLT\",\n    child_labels = \"visible\",\n    indent_mod = -1L,\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adae$AEHLT)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(\"AEDECOD\", .indent_mods = -1L) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 2L)\n\nresult &lt;- build_table(\n  lyt = lyt,\n  df = adae,\n  alt_counts_df = adsl\n) %&gt;%\n  prune_table() %&gt;%\n  # Sorted by decreasing frequency across all groups by System Organ Class, High-Level Term and Preferred Term.\n  sort_at_path(\n    path = c(\"AEBODSYS\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\"),\n    scorefun = cont_n_allcols\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEHLT\", \"*\", \"AEDECOD\"),\n    scorefun = score_occurrences\n  )\n\nresult\n\nBody System or Organ Class                                            A: Drug X                B: Placebo              C: Combination     \n  High Level Term                                                  F            M            F            M            F            M     \n    Dictionary-Derived Term                                      (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event       72 (91.1%)   50 (90.9%)   77 (93.9%)   46 (88.5%)   65 (92.9%)   55 (88.7%)\nOverall total number of events                                    377          232          419          203          378          325    \ncl A.1                                                                                                                                    \n  Total number of patients with at least one adverse event     53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)\n  Total number of events                                           85           47           93           37           86           74    \n  hlt A.1.1.1                                                                                                                             \n    Total number of patients with at least one adverse event   53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)\n    Total number of events                                         85           47           93           37           86           74    \n    dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)\n    dcd A.1.1.1.2                                              32 (40.5%)   16 (29.1%)   33 (40.2%)   15 (28.8%)   24 (34.3%)   26 (41.9%)\ncl B.2                                                                                                                                    \n  Total number of patients with at least one adverse event     46 (58.2%)   33 (60.0%)   45 (54.9%)   29 (55.8%)   44 (62.9%)   41 (66.1%)\n  Total number of events                                           81           48           86           52           64           79    \n  hlt B.2.2.3                                                                                                                             \n    Total number of patients with at least one adverse event   30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)\n    Total number of events                                         40           24           43           33           37           40    \n    dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)\n  hlt B.2.1.2                                                                                                                             \n    Total number of patients with at least one adverse event   29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)\n    Total number of events                                         41           24           43           19           27           39    \n    dcd B.2.1.2.1                                              29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)\ncl D.1                                                                                                                                    \n  Total number of patients with at least one adverse event     45 (57.0%)   34 (61.8%)   40 (48.8%)   27 (51.9%)   41 (58.6%)   39 (62.9%)\n  Total number of events                                           72           55           64           42           73           62    \n  hlt D.1.1.1                                                                                                                             \n    Total number of patients with at least one adverse event   25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)\n    Total number of events                                         32           29           36           15           39           32    \n    dcd D.1.1.1.1                                              25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)\n  hlt D.1.1.4                                                                                                                             \n    Total number of patients with at least one adverse event   30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)\n    Total number of events                                         40           26           28           27           34           30    \n    dcd D.1.1.4.2                                              30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)\ncl D.2                                                                                                                                    \n  Total number of patients with at least one adverse event     26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\n  Total number of events                                           35           27           49           23           43           31    \n  hlt D.2.1.5                                                                                                                             \n    Total number of patients with at least one adverse event   26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\n    Total number of events                                         35           27           49           23           43           31    \n    dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)\ncl B.1                                                                                                                                    \n  Total number of patients with at least one adverse event     28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)\n  Total number of events                                           33           23           36           24           35           27    \n  hlt B.1.1.1                                                                                                                             \n    Total number of patients with at least one adverse event   28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)\n    Total number of events                                         33           23           36           24           35           27    \n    dcd B.1.1.1.1                                              28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)\ncl C.2                                                                                                                                    \n  Total number of patients with at least one adverse event     23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)\n  Total number of events                                           32           16           39           14           33           32    \n  hlt C.2.1.2                                                                                                                             \n    Total number of patients with at least one adverse event   23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)\n    Total number of events                                         32           16           39           14           33           32    \n    dcd C.2.1.2.1                                              23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)\ncl C.1                                                                                                                                    \n  Total number of patients with at least one adverse event     30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n  Total number of events                                           39           16           52           11           44           20    \n  hlt C.1.1.1                                                                                                                             \n    Total number of patients with at least one adverse event   30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n    Total number of events                                         39           16           52           11           44           20    \n    dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\napp &lt;- teal::init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'),\n    cdisc_dataset(\"ADAE\", adae, code = 'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adae\"))'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events(\n      label = \"Adverse Event Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\", \"SEX\"), c(\"ARM\", \"SEX\")),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = \"AEBODSYS\"\n      ),\n      add_total = TRUE,\n      event_type = \"adverse event\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:18:21.1444 pid:10703 token:[] teal.modules.clinical Initializing tm_t_events\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet02_smq.html",
+    "href": "tables/adverse-events/aet02_smq.html",
+    "title": "AET02_SMQ",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Customized Queries\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\nlibrary(stringr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\n# Simulate a random AAG dataset.\naag &lt;- data.frame(\n  NAMVAR = c(\"SMQ01NAM\", \"SMQ01NAM\", \"SMQ02NAM\", \"CQ01NAM\", \"CQ01NAM\"),\n  SRCVAR = rep(\"AEDECOD\", 5),\n  GRPTYPE = c(\"SMQ\", \"SMQ\", \"SMQ\", \"CUSTOM\", \"CUSTOM\"),\n  REFID = c(1, 1, 2, 3, 3),\n  REFNAME = c(rep(\"C.1.1.1.3/B.2.2.3.1 AESI\", 2), \"non observed SMQ02NAM level\", rep(\"D.2.1.5.3/A.1.1.1.1 AESI\", 2)),\n  SCOPE = c(\"BROAD\", \"BROAD\", \"BROAD\", \"\", \"\"),\n  REFTERM = c(\"C.1.1.1.3\", \"B.2.2.3.1\", \"Z.9.9.9.9\", \"D.2.1.5.3\", \"A.1.1.1.1\"),\n  stringsAsFactors = FALSE\n)\n\n# Create summary AAG dataset (used for labelling).\n# Note it's important to incorporate SCOPE into the basket names for SMQs so as to\n# match the flags present in ADAE.\naag_summary &lt;- aag %&gt;%\n  select(NAMVAR, REFNAME, SCOPE) %&gt;%\n  unique() %&gt;%\n  mutate(\n    REFNAME_SCOPE = ifelse(SCOPE == \"\", REFNAME, paste0(REFNAME, \"(\", SCOPE, \")\"))\n  ) %&gt;%\n  rename(basket = NAMVAR, basket_name = REFNAME_SCOPE) %&gt;%\n  select(basket, basket_name)\n\n# Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function\nadae_smq_all &lt;- h_stack_by_baskets(df = adae, aag_summary = aag_summary, keys = c(\"STUDYID\", \"USUBJID\", \"ACTARMCD\", \"AEDECOD\"))\n\n# Post-process adae_smq_all to keep only certain baskets of interest for variant 1\n# Not need to drop baskets for variant 2 as all baskets will be considered.\nbaskets_to_drop_variant &lt;- aag_summary$basket_name[!aag_summary$basket %in% c(\"SMQ01NAM\")]\n\n# Adjust the analysis dataset based on basket subset for variant 1.\nadae_smq_1 &lt;- adae_smq_all %&gt;%\n  filter(!adae_smq_all$SMQ %in% baskets_to_drop_variant) %&gt;%\n  mutate(\n    SMQ = tern::fct_discard(SMQ, discard = baskets_to_drop_variant)\n  )\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) !is(tr, \"ContentRow\") && all_zero_or_na(tr)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    )\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    .indent_mods = -1L,\n    drop = FALSE\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nresult &lt;- build_table(\n  lyt,\n  df = adae_smq_1,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = cont_n_allcols) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                      ARM A        ARM B        ARM C   \n  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  \n—————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     72 (53.7%)   79 (59.0%)   75 (56.8%)\nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  \n  Total number of patients with at least one adverse event   72 (53.7%)   79 (59.0%)   75 (56.8%)\n  Total number of events                                        119          139          141    \n  dcd B.2.2.3.1                                              48 (35.8%)   54 (40.3%)   51 (38.6%)\n  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)\n\n\n\n\n\nCodecriteria_fun &lt;- function(tr) {\n  !is(tr, \"ContentRow\") && all_zero_or_na(tr) && !grepl(\"Total number of\", obj_label(tr))\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARMCD\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = trim_levels_in_group(\"AEDECOD\", drop_outlevs = FALSE),\n    label_pos = \"topleft\",\n    split_label = \"Standardized MedDRA Query\"\n  ) %&gt;%\n  analyze_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one adverse event\",\n      nonunique = \"Total number of events\"\n    ),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_occurrences(\n    vars = \"AEDECOD\",\n    drop = FALSE\n  ) %&gt;%\n  append_varlabels(adae, \"AEDECOD\", indent = 1L)\n\nscore_ae_pts &lt;- function(tt) {\n  count_vals &lt;- cell_values(tree_children(tt)[[\"USUBJID\"]])[[1]]\n  sum(matrix(unlist(count_vals), nrow = length(count_vals), byrow = TRUE)[, 1])\n}\n\nresult &lt;- build_table(\n  lyt,\n  df = adae_smq_all,\n  alt_counts_df = adsl\n) %&gt;%\n  sort_at_path(path = c(\"SMQ\"), scorefun = score_ae_pts) %&gt;%\n  sort_at_path(path = c(\"SMQ\", \"*\", \"AEDECOD\"), scorefun = score_occurrences, na.pos = \"last\") %&gt;%\n  trim_rows(criteria = criteria_fun)\n\nresult\n\nStandardized MedDRA Query                                      ARM A         ARM B         ARM C   \n  Dictionary-Derived Term                                     (N=134)       (N=134)       (N=132)  \n———————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one adverse event     95 (70.9%)   103 (76.9%)   108 (81.8%)\nD.2.1.5.3/A.1.1.1.1 AESI                                                                           \n  Total number of patients with at least one adverse event   74 (55.2%)   80 (59.7%)    87 (65.9%) \n  Total number of events                                        126           134           162    \n  dcd D.2.1.5.3                                              47 (35.1%)   58 (43.3%)    57 (43.2%) \n  dcd A.1.1.1.1                                              50 (37.3%)   45 (33.6%)    63 (47.7%) \nC.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                    \n  Total number of patients with at least one adverse event   72 (53.7%)   79 (59.0%)    75 (56.8%) \n  Total number of events                                        119           139           141    \n  dcd B.2.2.3.1                                              48 (35.8%)   54 (40.3%)    51 (38.6%) \n  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)    43 (32.6%) \nnon observed SMQ02NAM level(BROAD)                                                                 \n  Total number of patients with at least one adverse event       0             0             0     \n  Total number of events                                         0             0             0     \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nnames_baskets &lt;- grep(\"^(SMQ|CQ).*NAM$\", names(adae), value = TRUE)\nnames_scopes &lt;- grep(\"^SMQ.*SC$\", names(adae), value = TRUE)\n\ncs_baskets &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_baskets),\n  selected = names_baskets\n)\ncs_scopes &lt;- choices_selected(\n  choices = variable_choices(adae, subset = names_scopes),\n  selected = names_scopes,\n  fixed = TRUE\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'\n    ),\n    cdisc_dataset(\"ADAE\", adae,\n      code = 'ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_smq(\n      label = \"Adverse events by `SMQ` Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"SEX\")),\n        selected = \"ARM\"\n      ),\n      add_total = FALSE,\n      baskets = cs_baskets,\n      scopes = cs_scopes,\n      llt = choices_selected(\n        choices = variable_choices(adae, subset = c(\"AEDECOD\")),\n        selected = \"AEDECOD\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:19:16.0808 pid:10900 token:[] teal.modules.clinical Initializing tm_t_smq\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] stringr_1.5.0                scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          \n[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         \n[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      \n[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           \n[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     \n[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          \n[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        \n[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         \n[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           \n[85] forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet04.html",
+    "href": "tables/adverse-events/aet04.html",
+    "title": "AET04",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Fill-In  of Treatment Groups\nTable with Fill-In  of Grades\nTable with Collapsing  of Grades\nTable Using Worst Grade  Flags from ADAE\nTable with an Incidence Rate \\(\\geq\\) 40%, Totals Restricted\nTable with an Incidence Rate \\(\\geq\\) X%, Totals Unrestricted\nTable with an Incidence  Rate \\(\\geq\\) 58 Patients\nTable with a Difference in  Incidence Rate \\(\\geq\\) 10%\nTable with an Incidence Rate \\(\\geq\\) 5%, SOCs &lt; 5% Removed\nTable with an Incidence Rate \\(\\geq\\) 40%,  All SOCs w/o Preferred Terms Removed\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(tern)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl) %&gt;% filter(TRT01A != \"&lt;Missing&gt;\")\nadae &lt;- df_explicit_na(adae) %&gt;%\n  var_relabel(\n    AEBODSYS = \"MedDRA System Organ Class\",\n    AEDECOD = \"MedDRA Preferred Term\"\n  ) %&gt;%\n  filter(\n    ANL01FL == \"Y\",\n    AETOXGR != \"&lt;Missing&gt;\"\n  )\n\n# Pre-Processing\ngrade_groups &lt;- list(\n  \"Grade 1-2\" = c(\"1\", \"2\"),\n  \"Grade 3-4\" = c(\"3\", \"4\"),\n  \"Grade 5\" = \"5\"\n)\nadae$TOTAL_VAR &lt;- \"- Any adverse events - \"\n\n# Helper function to avoid filtering also the first part of the table, where general information is given.\nmy_row_condition &lt;- function(row_fnc_condition) {\n  function(table_row) {\n    if (indent_mod(table_row) == 0) {\n      return(TRUE)\n    } else {\n      row_fnc_condition(table_row)\n    }\n  }\n}\n\n# Helper function to calculate sum from first nested row\nscore_all_sum &lt;- function(tt) {\n  cleaf &lt;- collect_leaves(tt)[[1]]\n  if (NROW(cleaf) == 0) {\n    stop(\"score_all_sum score function used at subtable [\", obj_name(tt), \"] that has no content.\")\n  }\n  sum(sapply(row_values(cleaf), function(cv) cv[1]))\n}\n\n# Raw table used by variant 8/10\nraw_table &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\") %&gt;%\n  build_table(adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\")\n\nresult &lt;- lyt %&gt;%\n  build_table(adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodeadae2 &lt;- adae %&gt;% filter(ACTARM == \"A: Drug X\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\")\n\nresult &lt;- lyt %&gt;%\n  build_table(adae2, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)       0              0       \n                            Grade 1-2        10 (7.5%)        0              0       \n                            1                5 (3.7%)         0              0       \n                            2                5 (3.7%)         0              0       \n                            Grade 3-4       26 (19.4%)        0              0       \n                            3                13 (9.7%)        0              0       \n                            4                13 (9.7%)        0              0       \n                            Grade 5         64 (47.8%)        0              0       \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)        0              0       \n                            Grade 1-2       68 (50.7%)        0              0       \n                            1               27 (20.1%)        0              0       \n                            2               41 (30.6%)        0              0       \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)        0              0       \n                            Grade 1-2       45 (33.6%)        0              0       \n                            1               45 (33.6%)        0              0       \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)        0              0       \n                            Grade 1-2       41 (30.6%)        0              0       \n                            2               41 (30.6%)        0              0       \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)        0              0       \n                            Grade 3-4       22 (16.4%)        0              0       \n                            3               22 (16.4%)        0              0       \n                            Grade 5         42 (31.3%)        0              0       \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)        0              0       \n                            Grade 5         42 (31.3%)        0              0       \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)        0              0       \n                            Grade 3-4       38 (28.4%)        0              0       \n                            3               38 (28.4%)        0              0       \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)        0              0       \n                            Grade 1-2       23 (17.2%)        0              0       \n                            1               23 (17.2%)        0              0       \n                            Grade 3-4       39 (29.1%)        0              0       \n                            3               39 (29.1%)        0              0       \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)        0              0       \n                            Grade 3-4       39 (29.1%)        0              0       \n                            3               39 (29.1%)        0              0       \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)        0              0       \n                            Grade 1-2       38 (28.4%)        0              0       \n                            1               38 (28.4%)        0              0       \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)        0              0       \n                            Grade 5         38 (28.4%)        0              0       \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)        0              0       \n                            Grade 5         38 (28.4%)        0              0       \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)        0              0       \n                            Grade 1-2       37 (27.6%)        0              0       \n                            1               37 (27.6%)        0              0       \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)        0              0       \n                            Grade 1-2       37 (27.6%)        0              0       \n                            1               37 (27.6%)        0              0       \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)        0              0       \n                            Grade 3-4       36 (26.9%)        0              0       \n                            4               36 (26.9%)        0              0       \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)        0              0       \n                            Grade 3-4       36 (26.9%)        0              0       \n                            4               36 (26.9%)        0              0       \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)        0              0       \n                            Grade 1-2       28 (20.9%)        0              0       \n                            2               28 (20.9%)        0              0       \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)        0              0       \n                            Grade 1-2       28 (20.9%)        0              0       \n                            2               28 (20.9%)        0              0       \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\")\n\nresult &lt;- lyt %&gt;%\n  build_table(adae, alt_counts_df = adsl) %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            1                    0            0              0       \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            2                    0            0              0       \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            4                    0            0              0       \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            1                    0            0              0       \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            1                    0            0              0       \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5              0            0              0       \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4            0            0              0       \n                            3                    0            0              0       \n                            4                    0            0              0       \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            3                    0            0              0       \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 5              0            0              0       \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 1-2            0            0              0       \n                            1                    0            0              0       \n                            2                    0            0              0       \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            3                    0            0              0       \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 5              0            0              0       \n\n\n\n\n\nCodegrade_groups_1 &lt;- list(\n  \"Grade 1-2\" = c(\"1\", \"2\"),\n  \"Grade 3-5\" = c(\"3\", \"4\", \"5\")\n)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups_1,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups_1,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\")\n\nresult &lt;- lyt %&gt;%\n  build_table(adae, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-5       90 (67.2%)    83 (61.9%)     93 (70.5%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            5               64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-5       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-5       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-5       64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            5               42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 3-5       42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            5               42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-5       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 3-5       38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            5               38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 3-5       38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            5               38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-5       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-5       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCode# No Worst Grade Flags found in the ADAE data set.\n\n\n\n\n\nCode# Simple wrapper to return subset ADAE to a threshold of xx%.\nget_adae_trimmed &lt;- function(adsl, adae, cutoff_rate) {\n  n_per_arm &lt;- adsl %&gt;%\n    dplyr::count(ACTARM)\n\n  anl_terms &lt;- adae %&gt;%\n    dplyr::group_by(ACTARM, AEBODSYS, AEDECOD) %&gt;%\n    dplyr::count(\n      unique_terms = n_distinct(USUBJID)\n    ) %&gt;%\n    dplyr::select(-n) %&gt;%\n    dplyr::ungroup()\n\n  anl_terms &lt;- dplyr::left_join(\n    anl_terms,\n    n_per_arm,\n    by = \"ACTARM\"\n  ) %&gt;%\n    dplyr::mutate(\n      ae_rate = unique_terms / n\n    ) %&gt;%\n    dplyr::filter(ae_rate &gt;= cutoff_rate) %&gt;%\n    dplyr::select(AEDECOD) %&gt;%\n    unique()\n\n  anl &lt;- dplyr::left_join(\n    anl_terms,\n    adae,\n    by = \"AEDECOD\"\n  )\n  anl\n}\n\nadae6 &lt;- get_adae_trimmed(adsl, adae, cutoff_rate = 0.4)\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    var = \"TOTAL_VAR\",\n    label_pos = \"hidden\",\n    child_labels = \"visible\",\n    indent_mod = -1L\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 7L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 6L\n  ) %&gt;%\n  split_rows_by(\n    \"AEBODSYS\",\n    child_labels = \"visible\",\n    nested = FALSE,\n    split_fun = drop_split_levels,\n    split_label = var_labels(adae)[[\"AEBODSYS\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  split_rows_by(\n    \"AEDECOD\",\n    child_labels = \"visible\",\n    split_fun = add_overall_level(\"- Overall -\", trim = TRUE),\n    split_label = var_labels(adae)[[\"AEDECOD\"]],\n    label_pos = \"topleft\"\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = \"unique\",\n    .labels = \"- Any Grade -\",\n    .indent_mods = 6L\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    grade_groups = grade_groups,\n    .indent_mods = 5L\n  ) %&gt;%\n  append_topleft(\"                            Grade\")\n\nresult &lt;- lyt %&gt;%\n  build_table(adae6, alt_counts_df = adsl) %&gt;%\n  prune_table() %&gt;%\n  sort_at_path(\n    path = \"AEBODSYS\",\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  ) %&gt;%\n  sort_at_path(\n    path = c(\"AEBODSYS\", \"*\", \"AEDECOD\"),\n    scorefun = score_all_sum,\n    decreasing = TRUE\n  )\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCode# Variant 7 was not created.\n# With this variant, the SOC level is not trimmed (even if there are no terms left).\n\n\n\n\n\nCodecutoff &lt;- 58L\nrow_condition &lt;- has_count_in_any_col(atleast = cutoff, col_names = levels(adsl$ACTARM))\n\nresult &lt;- prune_table(raw_table, keep_content_rows(my_row_condition(row_condition)))\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodecutoff &lt;- 0.1\nrow_condition &lt;- has_fractions_difference(atleast = cutoff, col_names = levels(adsl$ACTARM))\n\nresult &lt;- prune_table(raw_table, keep_content_rows(my_row_condition(row_condition)))\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCode# Variant 10 was not done\n# With this variant, SOC levels above the threshold are still in the table even if\n# there are no terms left.\n\n\n\n\n\nCodecutoff &lt;- 0.4\nrow_condition &lt;- has_fraction_in_any_col(atleast = cutoff, col_names = levels(adsl$ACTARM))\n\nresult &lt;- prune_table(raw_table, keep_content_rows(my_row_condition(row_condition)))\n\nresult\n\nMedDRA System Organ Class                                                            \n  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination\n                            Grade             (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————\n- Any adverse events -                                                               \n                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  \n                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   \n                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   \n                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   \n                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  \n                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  \n                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  \n                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  \ncl A.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  \n                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \n  dcd A.1.1.1.1                                                                      \n                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  \n                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  \n  dcd A.1.1.1.2                                                                      \n                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  \n                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  \ncl B.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  \n                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \n  dcd B.2.2.3.1                                                                      \n                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  \n                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  \n  dcd B.2.1.2.1                                                                      \n                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  \n                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  \ncl D.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  \n                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.1.1                                                                      \n                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  \n                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  \n  dcd D.1.1.4.2                                                                      \n                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  \n                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  \ncl D.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \n  dcd D.2.1.5.3                                                                      \n                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  \n                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  \ncl C.2                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \n  dcd C.2.1.2.1                                                                      \n                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  \n                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  \ncl B.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \n  dcd B.1.1.1.1                                                                      \n                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  \n                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  \ncl C.1                                                                               \n  - Overall -                                                                        \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n  dcd C.1.1.1.3                                                                      \n                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  \n                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  \n\n\n\n\n\nCodelibrary(dplyr)\nlibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    cdisc_dataset(\"ADAE\", adae),\n    code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n    ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_by_grade(\n      label = \"Adverse Events by Grade Table\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      llt = choices_selected(\n        choices = variable_choices(adae, c(\"AETERM\", \"AEDECOD\")),\n        selected = c(\"AEDECOD\")\n      ),\n      hlt = choices_selected(\n        choices = variable_choices(adae, c(\"AEBODSYS\", \"AESOC\")),\n        selected = \"AEBODSYS\"\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adae, c(\"AETOXGR\", \"AESEV\")),\n        selected = \"AETOXGR\"\n      )\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:20:58.4365 pid:11096 token:[] teal.modules.clinical Initializing tm_t_events_by_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet01.html",
+    "href": "tables/adverse-events/aet01.html",
+    "title": "AET01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Medical  Concepts Section\nTable with  Modified Rows\nTable with Rows Counting  Events & Additional Sections\nteal App\nReproducibility\n\n\n\nTo illustrate, additional variables such as flags (TRUE/FALSE) for select AEs of interest and select AE baskets are added to the adae dataset.\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(\n  adae,\n  omit_columns = c(\"SMQ01NAM\", \"SMQ01SC\", \"SMQ02NAM\", \"SMQ02SC\", \"CQ01NAM\", \"STUDYID\", \"USUBJID\")\n)\n\nset.seed(99)\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AEDECOD = with_label(as.character(AEDECOD), \"Dictionary-Derived Term\"),\n    AESDTH = with_label(sample(c(\"N\", \"Y\"), size = nrow(adae), replace = TRUE, prob = c(0.99, 0.01)), \"Results in Death\"),\n    AEACN = with_label(sample(\n      c(\"DOSE NOT CHANGED\", \"DOSE INCREASED\", \"DRUG INTERRUPTED\", \"DRUG WITHDRAWN\"),\n      size = nrow(adae),\n      replace = TRUE, prob = c(0.68, 0.02, 0.25, 0.05)\n    ), \"Action Taken with Study Treatment\"),\n    FATAL = with_label(AESDTH == \"Y\", \"AE with fatal outcome\"),\n    SEV = with_label(AESEV == \"SEVERE\", \"Severe AE (at greatest intensity)\"),\n    SER = with_label(AESER == \"Y\", \"Serious AE\"),\n    SERWD = with_label(AESER == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Serious AE leading to withdrawal from treatment\"),\n    SERDSM = with_label(\n      AESER == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"Serious AE leading to dose modification/interruption\"\n    ),\n    RELSER = with_label(AESER == \"Y\" & AEREL == \"Y\", \"Related Serious AE\"),\n    WD = with_label(AEACN == \"DRUG WITHDRAWN\", \"AE leading to withdrawal from treatment\"),\n    DSM = with_label(\n      AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"AE leading to dose modification/interruption\"\n    ),\n    REL = with_label(AEREL == \"Y\", \"Related AE\"),\n    RELWD = with_label(AEREL == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Related AE leading to withdrawal from treatment\"),\n    RELDSM = with_label(\n      AEREL == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"Related AE leading to dose modification/interruption\"\n    ),\n    CTC35 = with_label(AETOXGR %in% c(\"3\", \"4\", \"5\"), \"Grade 3-5 AE\"),\n    CTC45 = with_label(AETOXGR %in% c(\"4\", \"5\"), \"Grade 4/5 AE\"),\n    SMQ01 = with_label(SMQ01NAM != \"\", aesi_label(adae$SMQ01NAM, adae$SMQ01SC)),\n    SMQ02 = with_label(SMQ02NAM != \"\", aesi_label(adae$SMQ02NAM, adae$SMQ02SC)),\n    CQ01 = with_label(CQ01NAM != \"\", aesi_label(adae$CQ01NAM)),\n    USUBJID_AESEQ = paste(USUBJID, AESEQ, sep = \"@@\") # Create unique ID per AE in dataset.\n  ) %&gt;%\n  filter(ANL01FL == \"Y\")\n\n\n\n\n\nCodeaesi_vars &lt;- c(\"FATAL\", \"SER\", \"SERWD\", \"SERDSM\", \"RELSER\", \"WD\", \"DSM\", \"REL\", \"RELWD\", \"RELDSM\", \"SEV\")\n\n# Layout for variables from adsl dataset.\nlyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DTHFL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of deaths\")\n  ) %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DCSREAS\" = \"ADVERSE EVENT\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients withdrawn from study due to an AE\"),\n    table_names = \"tot_wd\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl, alt_counts_df = adsl)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one AE\",\n      nonunique = \"Total number of AEs\"\n    ),\n    .formats = list(unique = format_count_fraction_fixed_dp, nonunique = \"xx\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_vars,\n    denom = \"N_col\",\n    var_labels = \"Total number of patients with at least one\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adae[1:2, ],\n  result_adsl,\n  result_adae[3:nrow(result_adae), ]\n)\n\nresult\n\n                                                              A: Drug X    B: Placebo   C: Combination\n                                                               (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                              502          480            604      \nTotal number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  \nTotal number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   \nTotal number of patients with at least one                                                            \n  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   \n  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  Serious AE leading to withdrawal from treatment             6 (4.5%)     12 (9.0%)       9 (6.8%)   \n  Serious AE leading to dose modification/interruption       36 (26.9%)    40 (29.9%)     47 (35.6%)  \n  Related Serious AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  \n  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  \n  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  \n  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  Related AE leading to withdrawal from treatment             10 (7.5%)     9 (6.7%)      12 (9.1%)   \n  Related AE leading to dose modification/interruption       44 (32.8%)    44 (32.8%)     51 (38.6%)  \n  Severe AE (at greatest intensity)                          77 (57.5%)    70 (52.2%)     79 (59.8%)  \n\n\n\n\n\nCodeaesi_vars &lt;- c(\"FATAL\", \"SER\", \"SERWD\", \"SERDSM\", \"RELSER\", \"WD\", \"DSM\", \"REL\", \"RELWD\", \"RELDSM\", \"CTC35\")\nbasket_vars &lt;- c(\"SMQ01\", \"SMQ02\", \"CQ01\")\n\n# Layout for variables from adsl dataset.\nlyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DTHFL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of deaths\")\n  ) %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DCSREAS\" = \"ADVERSE EVENT\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients withdrawn from study due to an AE\"),\n    table_names = \"tot_wd\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl, alt_counts_df = adsl)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one AE\",\n      nonunique = \"Total number of AEs\"\n    ),\n    .formats = list(unique = format_count_fraction_fixed_dp, nonunique = \"xx\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_vars,\n    denom = \"N_col\",\n    var_labels = \"Total number of patients with at least one\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = basket_vars,\n    table_names = \"table_aesi\",\n    denom = \"N_col\",\n    var_labels = \"Total number of patients with at least one\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adae[1:2, ],\n  result_adsl,\n  result_adae[3:nrow(result_adae), ]\n)\n\nresult\n\n                                                              A: Drug X    B: Placebo   C: Combination\n                                                               (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                              502          480            604      \nTotal number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  \nTotal number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   \nTotal number of patients with at least one                                                            \n  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   \n  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  Serious AE leading to withdrawal from treatment             6 (4.5%)     12 (9.0%)       9 (6.8%)   \n  Serious AE leading to dose modification/interruption       36 (26.9%)    40 (29.9%)     47 (35.6%)  \n  Related Serious AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  \n  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  \n  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  \n  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  Related AE leading to withdrawal from treatment             10 (7.5%)     9 (6.7%)      12 (9.1%)   \n  Related AE leading to dose modification/interruption       44 (32.8%)    44 (32.8%)     51 (38.6%)  \n  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  \nTotal number of patients with at least one                                                            \n  C.1.1.1.3/B.2.2.3.1 AESI (BROAD)                           58 (43.3%)    60 (44.8%)     66 (50.0%)  \n  SMQ 02 Reference Name                                           0            0              0       \n  D.2.1.5.3/A.1.1.1.1 AESI                                   62 (46.3%)    61 (45.5%)     76 (57.6%)  \n\n\n\n\n\nCodeaesi_vars &lt;- c(\"FATAL\", \"SER\", \"WD\", \"REL\", \"CTC35\", \"CTC45\")\n# Layout for variables from adsl dataset.\nlyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DTHFL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of deaths\")\n  ) %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DCSREAS\" = \"ADVERSE EVENT\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients withdrawn from study due to an AE\"),\n    table_names = \"tot_wd\"\n  ) %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DCSREAS\" = \"WITHDRAWAL BY SUBJECT\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients withdrawn informed consent\"),\n    table_names = \"tot_dscsreas_wd\"\n  )\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl, alt_counts_df = adsl)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one AE\",\n      nonunique = \"Total number of AEs\"\n    ),\n    .formats = list(unique = format_count_fraction_fixed_dp, nonunique = \"xx\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_vars,\n    denom = \"N_col\",\n    var_labels = \"Total number of patients with at least one\",\n    show_labels = \"visible\"\n  )\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adae[1:2, ],\n  result_adsl,\n  result_adae[3:nrow(result_adae), ]\n)\n\nresult\n\n                                                              A: Drug X    B: Placebo   C: Combination\n                                                               (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                              502          480            604      \nTotal number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  \nTotal number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   \nTotal number of patients withdrawn informed consent           1 (0.7%)      1 (0.7%)       1 (0.8%)   \nTotal number of patients with at least one                                                            \n  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   \n  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  \n  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  \n  Grade 4/5 AE                                               77 (57.5%)    70 (52.2%)     79 (59.8%)  \n\n\n\n\n\nCodecount_subj_vars &lt;- c(\"FATAL\", \"SER\", \"WD\", \"DSM\", \"REL\", \"CTC35\")\ncount_term_vars &lt;- c(\"SER\", \"DSM\", \"REL\", \"CTC35\", \"CTC45\")\ncount_ae_vars &lt;- c(\"SER\", \"DSM\", \"REL\", \"CTC35\", \"CTC45\")\n\n# Layout for variables from adsl dataset.\nlyt_adsl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DTHFL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of deaths\")\n  ) %&gt;%\n  count_patients_with_event(\n    \"USUBJID\",\n    filters = c(\"DCSREAS\" = \"ADVERSE EVENT\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients withdrawn from study due to an AE\"),\n    table_names = \"tot_wd\"\n  )\n\nresult_adsl &lt;- build_table(lyt_adsl, df = adsl, alt_counts_df = adsl)\n\n# Layout for variables from adae dataset.\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one AE\",\n      nonunique = \"Total number of AEs\"\n    ),\n    .formats = list(unique = format_count_fraction_fixed_dp, nonunique = \"xx\"),\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = count_subj_vars,\n    denom = \"N_col\",\n    var_labels = \"Total number of patients with at least one\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"AEDECOD\",\n    flag_variables = count_term_vars,\n    .stats = \"count\",\n    .formats = c(count = \"xx\"),\n    table_names = \"table_term\",\n    var_labels = \"Total number of unique preferred terms which are\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID_AESEQ\",\n    flag_variables = count_ae_vars,\n    .stats = \"count\",\n    .formats = c(count = \"xx\"),\n    table_names = \"table_ae\",\n    var_labels = \"Total number of adverse events which are\",\n    show_labels = \"visible\"\n  )\n\nresult_adae &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adsl) &lt;- col_info(result_adae)\nresult &lt;- rbind(\n  result_adae[1:2, ],\n  result_adsl,\n  result_adae[3:nrow(result_adae), ]\n)\n\nresult\n\n                                                              A: Drug X    B: Placebo   C: Combination\n                                                               (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                              502          480            604      \nTotal number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  \nTotal number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   \nTotal number of patients with at least one                                                            \n  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   \n  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  \n  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  \n  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  \nTotal number of unique preferred terms which are                                                      \n  Serious AE                                                      4            4              4       \n  AE leading to dose modification/interruption                   10            10             10      \n  Related AE                                                      5            5              5       \n  Grade 3-5 AE                                                    5            5              5       \n  Grade 4/5 AE                                                    3            3              3       \nTotal number of adverse events which are                                                              \n  Serious AE                                                     204          194            245      \n  AE leading to dose modification/interruption                   123          135            158      \n  Related AE                                                     231          231            290      \n  Grade 3-5 AE                                                   249          229            277      \n  Grade 4/5 AE                                                   143          134            168      \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadd_event_flags &lt;- function(dat) {\n  dat %&gt;%\n    dplyr::mutate(\n      TMPFL_SER = AESER == \"Y\",\n      TMPFL_REL = AEREL == \"Y\",\n      TMPFL_GR5 = AETOXGR == \"5\",\n      TMP_SMQ01 = !is.na(SMQ01NAM),\n      TMP_SMQ02 = !is.na(SMQ02NAM),\n      TMP_CQ01 = !is.na(CQ01NAM)\n    ) %&gt;%\n    var_relabel(\n      TMPFL_SER = \"Serious AE\",\n      TMPFL_REL = \"Related AE\",\n      TMPFL_GR5 = \"Grade 5 AE\",\n      TMP_SMQ01 = aesi_label(dat[[\"SMQ01NAM\"]], dat[[\"SMQ01SC\"]]),\n      TMP_SMQ02 = aesi_label(dat[[\"SMQ02NAM\"]], dat[[\"SMQ02SC\"]]),\n      TMP_CQ01 = aesi_label(dat[[\"CQ01NAM\"]])\n    )\n}\n\n# Generating user-defined event flags.\nadae &lt;- adae %&gt;% add_event_flags()\n\nae_anl_vars &lt;- names(adae)[startsWith(names(adae), \"TMPFL_\")]\naesi_vars &lt;- names(adae)[startsWith(names(adae), \"TMP_\")]\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADAE\", adae, code = 'ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n      add_event_flags &lt;- function(dat) {\n        dat %&gt;%\n          dplyr::mutate(\n            TMPFL_SER = AESER == \"Y\",\n            TMPFL_REL = AEREL == \"Y\",\n            TMPFL_GR5 = AETOXGR == \"5\",\n            TMP_SMQ01 = !is.na(SMQ01NAM),\n            TMP_SMQ02 = !is.na(SMQ02NAM),\n            TMP_CQ01 = !is.na(CQ01NAM)\n          ) %&gt;%\n          var_relabel(\n            TMPFL_SER = \"Serious AE\",\n            TMPFL_REL = \"Related AE\",\n            TMPFL_GR5 = \"Grade 5 AE\",\n            TMP_SMQ01 = aesi_label(dat[[\"SMQ01NAM\"]], dat[[\"SMQ01SC\"]]),\n            TMP_SMQ02 = aesi_label(dat[[\"SMQ02NAM\"]], dat[[\"SMQ02SC\"]]),\n            TMP_CQ01 = aesi_label(dat[[\"CQ01NAM\"]])\n          )\n      }\n      ADAE &lt;- ADAE %&gt;% add_event_flags()'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_summary(\n      label = \"Adverse Events Summary\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(\n        choices = variable_choices(\"ADSL\", c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      flag_var_anl = choices_selected(\n        choices = variable_choices(\"ADAE\", ae_anl_vars),\n        selected = ae_anl_vars[1],\n        keep_order = TRUE,\n        fixed = FALSE\n      ),\n      flag_var_aesi = choices_selected(\n        choices = variable_choices(\"ADAE\", aesi_vars),\n        selected = aesi_vars[1],\n        keep_order = TRUE,\n        fixed = FALSE\n      ),\n      add_total = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:22:18.1116 pid:11292 token:[] teal.modules.clinical Initializing tm_t_events_summary\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/adverse-events/aet01_aesi.html",
+    "href": "tables/adverse-events/aet01_aesi.html",
+    "title": "AET01_AESI",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with  Optional Lines\nTable For Studies  with Multiple Drugs\nTable of AEs  by SMQ\nteal App\nReproducibility\n\n\n\nTo illustrate, additional variables such as flags (TRUE/FALSE) for selected AEs of interest. Please consult your SAP on how to handle missing AE grades.\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadsl &lt;- filter(adsl, SAFFL == \"Y\")\nadae &lt;- filter(adae, ANL01FL == \"Y\" & SAFFL == \"Y\")\n\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nnot_resolved &lt;- adae %&gt;%\n  filter(!(AEOUT %in% c(\"RECOVERED/RESOLVED\", \"FATAL\", \"RECOVERED/RESOLVED WITH SEQUELAE\"))) %&gt;%\n  distinct(USUBJID) %&gt;%\n  mutate(NOT_RESOLVED = \"Y\")\n\nadae &lt;- adae %&gt;%\n  left_join(not_resolved, by = c(\"USUBJID\")) %&gt;%\n  mutate(\n    ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), \"Total number of patients with all non-fatal AEs resolved\"),\n    NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), \"Total number of patients with at least one unresolved or ongoing non-fatal AE\")\n  )\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AEDECOD = as.character(AEDECOD),\n    WD = with_label(AEACN == \"DRUG WITHDRAWN\", \"Total number of patients with study drug withdrawn due to AE\"),\n    DSM = with_label(\n      AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Total number of patients with dose modified/interrupted due to AE\"\n    ),\n    CONTRT = with_label(AECONTRT == \"Y\", \"Total number of patients with treatment received for AE\"),\n    SER = with_label(AESER == \"Y\", \"Total number of patients with at least one serious AE\"),\n    REL = with_label(AEREL == \"Y\", \"Total number of patients with at least one related AE\"),\n    ALL_RESOLVED_WD = with_label(WD == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with study drug withdrawn due to resolved AE\"),\n    ALL_RESOLVED_DSM = with_label(DSM == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with dose modified/interrupted due to resolved AE\"),\n    ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with treatment received for resolved AE\"),\n    NOT_RESOLVED_WD = with_label(WD == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with study drug withdrawn due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_DSM = with_label(DSM == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with dose modified/interrupted due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with treatment received for unresolved or ongoing AE\"),\n    SERWD = with_label(AESER == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"No. of patients with study drug withdrawn due to serious AE\"),\n    SERCONTRT = with_label(AECONTRT == \"Y\" & AESER == \"Y\", \"No. of patients with dose modified/interrupted due to serious AE\"),\n    SERDSM = with_label(\n      AESER == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"No. of patients with treatment received for serious AE\"\n    ),\n    RELWD = with_label(AEREL == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"No. of patients with study drug withdrawn due to related AE\"),\n    RELDSM = with_label(\n      AEREL == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose modified/interrupted due to related AE\"\n    ),\n    RELCONTRT = with_label(AECONTRT == \"Y\" & AEREL == \"Y\", \"No. of patients with treatment received for related AE\"),\n    RELSER = with_label(AESER == \"Y\" & AEREL == \"Y\", \"No. of patients with serious, related AE\")\n  )\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AETOXGR = forcats::fct_recode(AETOXGR,\n      \"Grade 1\" = \"1\",\n      \"Grade 2\" = \"2\",\n      \"Grade 3\" = \"3\",\n      \"Grade 4\" = \"4\",\n      \"Grade 5 (fatal outcome)\" = \"5\"\n    )\n  )\n\n\n\n\n\nCodeaesi_vars &lt;- c(\"WD\", \"DSM\", \"CONTRT\", \"ALL_RESOLVED\", \"NOT_RESOLVED\", \"SER\", \"REL\")\n\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    vars = \"USUBJID\",\n    filters = c(\"ANL01FL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients with at least one AE\")\n  ) %&gt;%\n  count_values(\n    \"ANL01FL\",\n    values = \"Y\",\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    var_labels = \"Total number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\"USUBJID\", flag_variables = aesi_vars, denom = \"N_col\")\n\nresult &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\nresult\n\n                                                                                 A: Drug X    B: Placebo   C: Combination\n                                                                                  (N=134)      (N=134)        (N=132)    \n—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                                   100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                                                 502          480            604      \nTotal number of patients with at least one AE by worst grade                                                             \n  Grade 1                                                                        5 (3.7%)      7 (5.2%)       4 (3.0%)   \n  Grade 2                                                                        5 (3.7%)      8 (6.0%)       6 (4.5%)   \n  Grade 3                                                                        13 (9.7%)    13 (9.7%)      14 (10.6%)  \n  Grade 4                                                                        13 (9.7%)    18 (13.4%)     15 (11.4%)  \n  Grade 5 (fatal outcome)                                                       64 (47.8%)    52 (38.8%)     64 (48.5%)  \nTotal number of patients with study drug withdrawn due to AE                    22 (16.4%)    21 (15.7%)     28 (21.2%)  \nTotal number of patients with dose modified/interrupted due to AE               55 (41.0%)    62 (46.3%)     64 (48.5%)  \nTotal number of patients with treatment received for AE                         80 (59.7%)    80 (59.7%)     89 (67.4%)  \nTotal number of patients with all non-fatal AEs resolved                        17 (12.7%)    12 (9.0%)      11 (8.3%)   \nTotal number of patients with at least one unresolved or ongoing non-fatal AE   83 (61.9%)    86 (64.2%)     92 (69.7%)  \nTotal number of patients with at least one serious AE                           85 (63.4%)    80 (59.7%)     87 (65.9%)  \nTotal number of patients with at least one related AE                           86 (64.2%)    85 (63.4%)     92 (69.7%)  \n\n\n\n\n\nCodeaesi_vars &lt;- c(\"WD\", \"DSM\", \"CONTRT\")\naesi_resolved &lt;- c(\"ALL_RESOLVED\", \"ALL_RESOLVED_WD\", \"ALL_RESOLVED_DSM\", \"ALL_RESOLVED_CONTRT\")\naesi_not_resolved &lt;- c(\"NOT_RESOLVED\", \"NOT_RESOLVED_WD\", \"NOT_RESOLVED_DSM\", \"NOT_RESOLVED_CONTRT\")\naesi_ser &lt;- c(\"SER\", \"SERWD\", \"SERDSM\", \"SERCONTRT\")\naesi_rel &lt;- c(\"REL\", \"RELWD\", \"RELDSM\", \"RELCONTRT\", \"RELSER\")\n\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    vars = \"USUBJID\",\n    filters = c(\"ANL01FL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients with at least one AE\")\n  ) %&gt;%\n  count_values(\n    \"ANL01FL\",\n    values = \"Y\",\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    var_labels = \"Total number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(aesi_vars, aesi_resolved[1]), denom = \"N_col\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_resolved[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_res\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_not_resolved[1], denom = \"N_col\", table_names = \"fl_notres_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_not_resolved[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_notres\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_ser[1], denom = \"N_col\", table_names = \"fl_ser_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_ser[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_ser\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel[1], denom = \"N_col\", table_names = \"fl_rel_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_rel\"\n  )\n\nresult &lt;- build_table(lyt_adae, df = adae, alt_counts_df = adsl)\nresult\n\n                                                                                    A: Drug X    B: Placebo   C: Combination\n                                                                                     (N=134)      (N=134)        (N=132)    \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                                      100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                                                    502          480            604      \nTotal number of patients with at least one AE by worst grade                                                                \n  Grade 1                                                                           5 (3.7%)      7 (5.2%)       4 (3.0%)   \n  Grade 2                                                                           5 (3.7%)      8 (6.0%)       6 (4.5%)   \n  Grade 3                                                                           13 (9.7%)    13 (9.7%)      14 (10.6%)  \n  Grade 4                                                                           13 (9.7%)    18 (13.4%)     15 (11.4%)  \n  Grade 5 (fatal outcome)                                                          64 (47.8%)    52 (38.8%)     64 (48.5%)  \nTotal number of patients with study drug withdrawn due to AE                       22 (16.4%)    21 (15.7%)     28 (21.2%)  \nTotal number of patients with dose modified/interrupted due to AE                  55 (41.0%)    62 (46.3%)     64 (48.5%)  \nTotal number of patients with treatment received for AE                            80 (59.7%)    80 (59.7%)     89 (67.4%)  \nTotal number of patients with all non-fatal AEs resolved                           17 (12.7%)    12 (9.0%)      11 (8.3%)   \n  No. of patients with study drug withdrawn due to resolved AE                          0         1 (0.7%)       2 (1.5%)   \n  No. of patients with dose modified/interrupted due to resolved AE                 3 (2.2%)      4 (3.0%)       2 (1.5%)   \n  No. of patients with treatment received for resolved AE                           9 (6.7%)      7 (5.2%)       7 (5.3%)   \nTotal number of patients with at least one unresolved or ongoing non-fatal AE      83 (61.9%)    86 (64.2%)     92 (69.7%)  \n  No. of patients with study drug withdrawn due to unresolved or ongoing AE        22 (16.4%)    20 (14.9%)     26 (19.7%)  \n  No. of patients with dose modified/interrupted due to unresolved or ongoing AE   52 (38.8%)    58 (43.3%)     62 (47.0%)  \n  No. of patients with treatment received for unresolved or ongoing AE             71 (53.0%)    73 (54.5%)     82 (62.1%)  \nTotal number of patients with at least one serious AE                              85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  No. of patients with study drug withdrawn due to serious AE                       9 (6.7%)      4 (3.0%)      10 (7.6%)   \n  No. of patients with treatment received for serious AE                           21 (15.7%)    22 (16.4%)     28 (21.2%)  \n  No. of patients with dose modified/interrupted due to serious AE                 59 (44.0%)    58 (43.3%)     53 (40.2%)  \nTotal number of patients with at least one related AE                              86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  No. of patients with study drug withdrawn due to related AE                       5 (3.7%)     10 (7.5%)       7 (5.3%)   \n  No. of patients with dose modified/interrupted due to related AE                 24 (17.9%)    32 (23.9%)     34 (25.8%)  \n  No. of patients with treatment received for related AE                           53 (39.6%)    58 (43.3%)     60 (45.5%)  \n  No. of patients with serious, related AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  \n\n\n\n\n\nCodeadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae_mult &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadsl &lt;- filter(adsl, SAFFL == \"Y\")\nadae_mult &lt;- filter(adae_mult, ANL01FL == \"Y\" & SAFFL == \"Y\")\n\nadsl &lt;- df_explicit_na(adsl)\nadae_mult &lt;- df_explicit_na(adae_mult)\n\n# for illustration purposes only, create AEREL1, AEREL2, AEACN1, AEACN2 from respective variables\nadae_mult &lt;- adae_mult %&gt;%\n  mutate(\n    AEREL1 = AEREL,\n    AEREL2 = AEREL,\n    AEACN1 = AEACN,\n    AEACN2 = AEACN\n  )\n\nnot_resolved &lt;- adae_mult %&gt;%\n  filter(!(AEOUT %in% c(\"RECOVERED/RESOLVED\", \"FATAL\", \"RECOVERED/RESOLVED WITH SEQUELAE\"))) %&gt;%\n  distinct(USUBJID) %&gt;%\n  mutate(NOT_RESOLVED = \"Y\")\n\nadae_mult &lt;- adae_mult %&gt;%\n  left_join(not_resolved, by = c(\"USUBJID\")) %&gt;%\n  mutate(\n    ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), \"Total number of patients with all non-fatal AEs resolved\"),\n    NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), \"Total number of patients with at least one non-fatal unresolved or ongoing AE\")\n  )\n\nadae_mult &lt;- adae_mult %&gt;%\n  mutate(\n    AEDECOD = as.character(AEDECOD),\n    WD1 = with_label(AEACN1 == \"DRUG WITHDRAWN\", \"Total number of patients with study drug 1 withdrawn due to AE\"),\n    WD2 = with_label(AEACN2 == \"DRUG WITHDRAWN\", \"Total number of patients with study drug 2 withdrawn due to AE\"),\n    DSM1 = with_label(\n      AEACN1 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"Total number of patients with dose of study drug 1 modified/interrupted due to AE\"\n    ),\n    DSM2 = with_label(\n      AEACN2 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"Total number of patients with dose of study drug 2 modified/interrupted due to AE\"\n    ),\n    CONTRT = with_label(AECONTRT == \"Y\", \"Total number of patients with treatment received for AE\"),\n    SER = with_label(AESER == \"Y\", \"Total number of patients with at least one serious AE\"),\n    REL1 = with_label(AEREL1 == \"Y\", \"Total number of patients with at least one AE related to study drug 1\"),\n    REL2 = with_label(AEREL2 == \"Y\", \"Total number of patients with at least one AE related to study drug 2\"),\n    ALL_RESOLVED_WD1 = with_label(WD1 == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with study drug 1 withdrawn due to resolved AE\"),\n    ALL_RESOLVED_DSM1 = with_label(\n      DSM1 == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with dose of study drug 1 modified/interrupted due to resolved AE\"\n    ),\n    ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with treatment received for resolved AE\"),\n    ALL_RESOLVED_WD2 = with_label(WD2 == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with study drug 2 withdrawn due to resolved AE\"),\n    ALL_RESOLVED_DSM2 = with_label(\n      DSM2 == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with dose of study drug 2 modified/interrupted due to resolved AE\"\n    ),\n    NOT_RESOLVED_WD1 = with_label(WD1 == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with study drug 1 withdrawn due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_DSM1 = with_label(\n      DSM1 == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with dose of study drug 1 modified/interrupted due to unresolved or ongoing AE\"\n    ),\n    NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with treatment received for unresolved or ongoing AE\"),\n    NOT_RESOLVED_WD2 = with_label(WD2 == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with study drug 2 withdrawn due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_DSM2 = with_label(\n      DSM2 == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with dose of study drug 2 modified/interrupted due to unresolved or ongoing AE\"\n    ),\n    SERWD1 = with_label(AESER == \"Y\" & AEACN1 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 1 withdrawn due to serious AE\"),\n    SERWD2 = with_label(AESER == \"Y\" & AEACN2 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 2 withdrawn due to serious AE\"),\n    SERCONTRT = with_label(AECONTRT == \"Y\" & AESER == \"Y\", \"No. of patients with treatment received for serious AE\"),\n    SERDSM1 = with_label(\n      AESER == \"Y\" & AEACN1 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 1 modified/interrupted due to serious AE\"\n    ),\n    SERDSM2 = with_label(\n      AESER == \"Y\" & AEACN2 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 2 modified/interrupted due to serious AE\"\n    ),\n    REL1WD1 = with_label(AEREL1 == \"Y\" & AEACN1 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 1 withdrawn due to AE related to study drug 1\"),\n    REL1WD2 = with_label(AEREL1 == \"Y\" & AEACN2 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 1 withdrawn due to AE related to study drug 2\"),\n    REL2WD1 = with_label(AEREL1 == \"Y\" & AEACN1 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 2 withdrawn due to AE related to study drug 1\"),\n    REL2WD2 = with_label(AEREL1 == \"Y\" & AEACN2 == \"DRUG WITHDRAWN\", \"No. of patients with study drug 2 withdrawn due to AE related to study drug 2\"),\n    REL1DSM1 = with_label(\n      AEREL1 == \"Y\" & AEACN1 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 1\"\n    ),\n    REL2DSM1 = with_label(\n      AEREL2 == \"Y\" & AEACN1 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 1\"\n    ),\n    REL1DSM2 = with_label(\n      AEREL1 == \"Y\" & AEACN2 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 2\"\n    ),\n    REL2DSM2 = with_label(\n      AEREL2 == \"Y\" & AEACN2 %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 2\"\n    ),\n    REL1CONTRT = with_label(AECONTRT == \"Y\" & AEREL1 == \"Y\", \"No. of patients with treatment received for AE related to study drug 1\"),\n    REL2CONTRT = with_label(AECONTRT == \"Y\" & AEREL2 == \"Y\", \"No. of patients with treatment received for AE related to study drug 2\"),\n    REL1SER = with_label(AESER == \"Y\" & AEREL1 == \"Y\", \"No. of patients with serious AE related to study drug 1\"),\n    REL2SER = with_label(AESER == \"Y\" & AEREL2 == \"Y\", \"No. of patients with serious AE related to study drug 2\")\n  )\n\nadae_mult &lt;- adae_mult %&gt;%\n  mutate(AETOXGR = forcats::fct_recode(\n    AETOXGR,\n    \"Grade 1\" = \"1\",\n    \"Grade 2\" = \"2\",\n    \"Grade 3\" = \"3\",\n    \"Grade 4\" = \"4\",\n    \"Grade 5 (fatal outcome)\" = \"5\"\n  ))\n\naesi_vars &lt;- c(\"WD1\", \"WD2\", \"DSM1\", \"DSM2\", \"CONTRT\")\naesi_res &lt;- c(\"ALL_RESOLVED\", \"ALL_RESOLVED_WD1\", \"ALL_RESOLVED_WD2\", \"ALL_RESOLVED_DSM1\", \"ALL_RESOLVED_DSM2\", \"ALL_RESOLVED_CONTRT\")\naesi_not_res &lt;- c(\"NOT_RESOLVED\", \"NOT_RESOLVED_WD1\", \"NOT_RESOLVED_WD2\", \"NOT_RESOLVED_DSM1\", \"NOT_RESOLVED_DSM2\", \"NOT_RESOLVED_CONTRT\")\naesi_ser &lt;- c(\"SER\", \"SERWD1\", \"SERWD2\", \"SERDSM1\", \"SERDSM2\", \"SERCONTRT\")\naesi_rel1 &lt;- c(\"REL1\", \"REL1WD1\", \"REL1WD2\", \"REL1DSM1\", \"REL1DSM2\", \"REL1CONTRT\", \"REL1SER\")\naesi_rel2 &lt;- c(\"REL2\", \"REL2WD1\", \"REL2WD2\", \"REL2DSM1\", \"REL2DSM2\", \"REL2CONTRT\", \"REL2SER\")\n\nlyt_adae_mult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  count_patients_with_event(\n    vars = \"USUBJID\",\n    filters = c(\"ANL01FL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients with at least one AE\")\n  ) %&gt;%\n  count_values(\n    \"ANL01FL\",\n    values = \"Y\",\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    var_labels = \"Total number of patients with at least one AE by worst grade\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(aesi_vars, aesi_res[1]), denom = \"N_col\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_res[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_res\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_not_res[1], denom = \"N_col\", table_names = \"fl_notres_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_not_res[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_notres\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_ser[1], denom = \"N_col\", table_names = \"fl_ser_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_ser[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_ser\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel1[1], denom = \"N_col\", table_names = \"fl_rel1_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel1[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_rel1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel2[1], denom = \"N_col\", table_names = \"fl_rel2_main\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = aesi_rel2[-1], denom = \"N_col\", .indent_mods = 1L, table_names = \"fl_rel2\"\n  )\n\nresult &lt;- build_table(lyt_adae_mult, df = adae_mult, alt_counts_df = adsl)\nresult\n\n                                                                                                      A: Drug X    B: Placebo   C: Combination\n                                                                                                       (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one AE                                                        100 (74.6%)   98 (73.1%)    103 (78.0%)  \nTotal number of AEs                                                                                      502          480            604      \nTotal number of patients with at least one AE by worst grade                                                                                  \n  Grade 1                                                                                             5 (3.7%)      7 (5.2%)       4 (3.0%)   \n  Grade 2                                                                                             5 (3.7%)      8 (6.0%)       6 (4.5%)   \n  Grade 3                                                                                             13 (9.7%)    13 (9.7%)      14 (10.6%)  \n  Grade 4                                                                                             13 (9.7%)    18 (13.4%)     15 (11.4%)  \n  Grade 5 (fatal outcome)                                                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  \nTotal number of patients with study drug 1 withdrawn due to AE                                       22 (16.4%)    21 (15.7%)     28 (21.2%)  \nTotal number of patients with study drug 2 withdrawn due to AE                                       22 (16.4%)    21 (15.7%)     28 (21.2%)  \nTotal number of patients with dose of study drug 1 modified/interrupted due to AE                    55 (41.0%)    62 (46.3%)     64 (48.5%)  \nTotal number of patients with dose of study drug 2 modified/interrupted due to AE                    55 (41.0%)    62 (46.3%)     64 (48.5%)  \nTotal number of patients with treatment received for AE                                              80 (59.7%)    80 (59.7%)     89 (67.4%)  \nTotal number of patients with all non-fatal AEs resolved                                             17 (12.7%)    12 (9.0%)      11 (8.3%)   \n  No. of patients with study drug 1 withdrawn due to resolved AE                                          0         1 (0.7%)       2 (1.5%)   \n  No. of patients with study drug 2 withdrawn due to resolved AE                                          0         1 (0.7%)       2 (1.5%)   \n  No. of patients with dose of study drug 1 modified/interrupted due to resolved AE                   3 (2.2%)      4 (3.0%)       2 (1.5%)   \n  No. of patients with dose of study drug 2 modified/interrupted due to resolved AE                   3 (2.2%)      4 (3.0%)       2 (1.5%)   \n  No. of patients with treatment received for resolved AE                                             9 (6.7%)      7 (5.2%)       7 (5.3%)   \nTotal number of patients with at least one non-fatal unresolved or ongoing AE                        83 (61.9%)    86 (64.2%)     92 (69.7%)  \n  No. of patients with study drug 1 withdrawn due to unresolved or ongoing AE                        22 (16.4%)    20 (14.9%)     26 (19.7%)  \n  No. of patients with study drug 2 withdrawn due to unresolved or ongoing AE                        22 (16.4%)    20 (14.9%)     26 (19.7%)  \n  No. of patients with dose of study drug 1 modified/interrupted due to unresolved or ongoing AE     52 (38.8%)    58 (43.3%)     62 (47.0%)  \n  No. of patients with dose of study drug 2 modified/interrupted due to unresolved or ongoing AE     52 (38.8%)    58 (43.3%)     62 (47.0%)  \n  No. of patients with treatment received for unresolved or ongoing AE                               71 (53.0%)    73 (54.5%)     82 (62.1%)  \nTotal number of patients with at least one serious AE                                                85 (63.4%)    80 (59.7%)     87 (65.9%)  \n  No. of patients with study drug 1 withdrawn due to serious AE                                       9 (6.7%)      4 (3.0%)      10 (7.6%)   \n  No. of patients with study drug 2 withdrawn due to serious AE                                       9 (6.7%)      4 (3.0%)      10 (7.6%)   \n  No. of patients with dose of study drug 1 modified/interrupted due to serious AE                   21 (15.7%)    22 (16.4%)     28 (21.2%)  \n  No. of patients with dose of study drug 2 modified/interrupted due to serious AE                   21 (15.7%)    22 (16.4%)     28 (21.2%)  \n  No. of patients with treatment received for serious AE                                             59 (44.0%)    58 (43.3%)     53 (40.2%)  \nTotal number of patients with at least one AE related to study drug 1                                86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  No. of patients with study drug 1 withdrawn due to AE related to study drug 1                       5 (3.7%)     10 (7.5%)       7 (5.3%)   \n  No. of patients with study drug 1 withdrawn due to AE related to study drug 2                       5 (3.7%)     10 (7.5%)       7 (5.3%)   \n  No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 1   24 (17.9%)    32 (23.9%)     34 (25.8%)  \n  No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 2   24 (17.9%)    32 (23.9%)     34 (25.8%)  \n  No. of patients with treatment received for AE related to study drug 1                             53 (39.6%)    58 (43.3%)     60 (45.5%)  \n  No. of patients with serious AE related to study drug 1                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  \nTotal number of patients with at least one AE related to study drug 2                                86 (64.2%)    85 (63.4%)     92 (69.7%)  \n  No. of patients with study drug 2 withdrawn due to AE related to study drug 1                       5 (3.7%)     10 (7.5%)       7 (5.3%)   \n  No. of patients with study drug 2 withdrawn due to AE related to study drug 2                       5 (3.7%)     10 (7.5%)       7 (5.3%)   \n  No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 1   24 (17.9%)    32 (23.9%)     34 (25.8%)  \n  No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 2   24 (17.9%)    32 (23.9%)     34 (25.8%)  \n  No. of patients with treatment received for AE related to study drug 2                             53 (39.6%)    58 (43.3%)     60 (45.5%)  \n  No. of patients with serious AE related to study drug 2                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  \n\n\n\n\n\nCodeadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n\nadsl &lt;- filter(adsl, SAFFL == \"Y\")\nadae &lt;- filter(adae, ANL01FL == \"Y\" & SAFFL == \"Y\")\n\nadsl &lt;- df_explicit_na(adsl)\nadae &lt;- df_explicit_na(adae)\n\nstack_adae_by_smq &lt;- function(adae, smq) {\n  adae_labels &lt;- c(var_labels(adae), \"Standardized MedDRA Query\")\n  l_df &lt;- lapply(smq, function(ae_grp) {\n    ae_scope &lt;- gsub(\"NAM\", \"SC\", ae_grp)\n    keep &lt;- adae[[ae_grp]] != \"&lt;Missing&gt;\"\n    df &lt;- adae[keep, ]\n    if (substr(ae_grp, 1, 3) == \"SMQ\") {\n      df[[\"SMQ\"]] &lt;- aesi_label(as.character(df[[ae_grp]]), scope = as.character(df[[ae_scope]]))\n    } else {\n      df[[\"SMQ\"]] &lt;- df[[ae_grp]]\n    }\n    df\n  })\n  result &lt;- do.call(rbind, l_df)\n  var_labels(result) &lt;- adae_labels\n  result\n}\n\nadae_smq &lt;- stack_adae_by_smq(adae, c(\"SMQ01NAM\", \"SMQ02NAM\", \"CQ01NAM\"))\n\nnot_resolved &lt;- adae_smq %&gt;%\n  filter(!(AEOUT %in% c(\"RECOVERED/RESOLVED\", \"FATAL\", \"RECOVERED/RESOLVED WITH SEQUELAE\"))) %&gt;%\n  distinct(USUBJID) %&gt;%\n  mutate(NOT_RESOLVED = \"Y\")\n\nadae_smq &lt;- adae_smq %&gt;%\n  left_join(not_resolved, by = c(\"USUBJID\")) %&gt;%\n  mutate(\n    ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), \"Total number of patients with all non-fatal AEs resolved\"),\n    NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), \"Total number of patients with at least one non-fatal unresolved or ongoing AE\")\n  )\n\nadae_smq &lt;- adae_smq %&gt;%\n  mutate(\n    AEDECOD = as.character(AEDECOD),\n    WD = with_label(AEACN == \"DRUG WITHDRAWN\", \"Total number of patients with study drug withdrawn due to AE\"),\n    DSM = with_label(\n      AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Total number of patients with dose modified/interrupted due to AE\"\n    ),\n    CONTRT = with_label(AECONTRT == \"Y\", \"Total number of patients with treatment received for AE\"),\n    SER = with_label(AESER == \"Y\", \"Total number of patients with at least one serious AE\"),\n    REL = with_label(AEREL == \"Y\", \"Total number of patients with at least one related AE\"),\n    ALL_RESOLVED_WD = with_label(WD == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with study drug withdrawn due to resolved AE\"),\n    ALL_RESOLVED_DSM = with_label(DSM == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with dose modified/interrupted due to resolved AE\"),\n    ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE & ALL_RESOLVED == TRUE, \"No. of patients with treatment received for resolved AE\"),\n    NOT_RESOLVED_WD = with_label(WD == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with study drug withdrawn due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_DSM = with_label(DSM == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with dose modified/interrupted due to unresolved or ongoing AE\"),\n    NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE & NOT_RESOLVED == TRUE, \"No. of patients with treatment received for unresolved or ongoing AE\"),\n    SERWD = with_label(AESER == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"No. of patients with study drug withdrawn due to serious AE\"),\n    SERCONTRT = with_label(AECONTRT == \"Y\" & AESER == \"Y\", \"No. of patients with treatment received for serious AE\"),\n    SERDSM = with_label(\n      AESER == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose modified/interrupted due to serious AE\"\n    ),\n    RELWD = with_label(AEREL == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"No. of patients with study drug withdrawn due to related AE\"),\n    RELDSM = with_label(\n      AEREL == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"),\n      \"No. of patients with dose modified/interrupted due to related AE\"\n    ),\n    RELCONTRT = with_label(AECONTRT == \"Y\" & AEREL == \"Y\", \"No. of patients with treatment received for related AE\"),\n    RELSER = with_label(AESER == \"Y\" & AEREL == \"Y\", \"No. of patients with serious, related AE\")\n  )\n\nadae_smq &lt;- adae_smq %&gt;%\n  mutate(\n    AETOXGR = forcats::fct_recode(AETOXGR,\n      \"Grade 1\" = \"1\",\n      \"Grade 2\" = \"2\",\n      \"Grade 3\" = \"3\",\n      \"Grade 4\" = \"4\",\n      \"Grade 5 (fatal outcome)\" = \"5\"\n    )\n  )\n\nsplit_fun &lt;- remove_split_levels(\"&lt;Missing&gt;\")\naesi_vars &lt;- c(\"WD\", \"DSM\", \"CONTRT\", \"ALL_RESOLVED\", \"NOT_RESOLVED\", \"SER\", \"REL\")\n\nlyt_adae &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"SMQ\",\n    child_labels = \"visible\",\n    split_fun = split_fun,\n    split_label = \"Standardized MedDRA Query\",\n    label_pos = \"topleft\"\n  ) %&gt;%\n  count_patients_with_event(\n    vars = \"USUBJID\",\n    filters = c(\"ANL01FL\" = \"Y\"),\n    denom = \"N_col\",\n    .labels = c(count_fraction = \"Total number of patients with at least one AE\")\n  ) %&gt;%\n  count_values(\n    \"ANL01FL\",\n    values = \"Y\",\n    .stats = \"count\",\n    .labels = c(count = \"Total number of AEs\"),\n    table_names = \"total_aes\"\n  ) %&gt;%\n  count_occurrences_by_grade(\n    var = \"AETOXGR\",\n    var_labels = \"Total number of patients with at least one AE by worst grade\",\n    .show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\"USUBJID\", flag_variables = aesi_vars, denom = \"N_col\")\n\nresult &lt;- build_table(lyt_adae, df = adae_smq, alt_counts_df = adsl)\nresult\n\nStandardized MedDRA Query                                                         A: Drug X    B: Placebo   C: Combination\n                                                                                   (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nC.1.1.1.3/B.2.2.3.1 AESI (BROAD)                                                                                          \n  Total number of patients with at least one AE                                   58 (43.3%)   60 (44.8%)     66 (50.0%)  \n  Total number of AEs                                                                 97          106            122      \n  Total number of patients with at least one AE by worst grade                                                            \n    Grade 1                                                                       22 (16.4%)   26 (19.4%)     30 (22.7%)  \n    Grade 2                                                                           0            0              0       \n    Grade 3                                                                           0            0              0       \n    Grade 4                                                                       36 (26.9%)   34 (25.4%)     36 (27.3%)  \n    Grade 5 (fatal outcome)                                                           0            0              0       \n  Total number of patients with study drug withdrawn due to AE                     5 (3.7%)     6 (4.5%)       9 (6.8%)   \n  Total number of patients with dose modified/interrupted due to AE               21 (15.7%)   21 (15.7%)     24 (18.2%)  \n  Total number of patients with treatment received for AE                         32 (23.9%)   35 (26.1%)     44 (33.3%)  \n  Total number of patients with all non-fatal AEs resolved                         7 (5.2%)     9 (6.7%)       8 (6.1%)   \n  Total number of patients with at least one non-fatal unresolved or ongoing AE   51 (38.1%)   51 (38.1%)     58 (43.9%)  \n  Total number of patients with at least one serious AE                           38 (28.4%)   40 (29.9%)     45 (34.1%)  \n  Total number of patients with at least one related AE                           36 (26.9%)   34 (25.4%)     36 (27.3%)  \nD.2.1.5.3/A.1.1.1.1 AESI                                                                                                  \n  Total number of patients with at least one AE                                   62 (46.3%)   61 (45.5%)     76 (57.6%)  \n  Total number of AEs                                                                106          100            139      \n  Total number of patients with at least one AE by worst grade                                                            \n    Grade 1                                                                       62 (46.3%)   61 (45.5%)     76 (57.6%)  \n    Grade 2                                                                           0            0              0       \n    Grade 3                                                                           0            0              0       \n    Grade 4                                                                           0            0              0       \n    Grade 5 (fatal outcome)                                                           0            0              0       \n  Total number of patients with study drug withdrawn due to AE                     6 (4.5%)     8 (6.0%)       4 (3.0%)   \n  Total number of patients with dose modified/interrupted due to AE               23 (17.2%)   20 (14.9%)     26 (19.7%)  \n  Total number of patients with treatment received for AE                         33 (24.6%)   37 (27.6%)     33 (25.0%)  \n  Total number of patients with all non-fatal AEs resolved                         4 (3.0%)     5 (3.7%)      14 (10.6%)  \n  Total number of patients with at least one non-fatal unresolved or ongoing AE   58 (43.3%)   56 (41.8%)     62 (47.0%)  \n  Total number of patients with at least one serious AE                               0            0              0       \n  Total number of patients with at least one related AE                           37 (27.6%)   46 (34.3%)     50 (37.9%)  \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadae &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\nadae &lt;- filter(adae, ANL01FL == \"Y\" & SAFFL == \"Y\")\n\nnot_resolved &lt;- adae %&gt;%\n  filter(!(AEOUT %in% c(\"RECOVERED/RESOLVED\", \"FATAL\", \"RECOVERED/RESOLVED WITH SEQUELAE\"))) %&gt;%\n  distinct(USUBJID) %&gt;%\n  mutate(NOT_RESOLVED = \"Y\")\n\nadae &lt;- adae %&gt;%\n  left_join(not_resolved, by = c(\"USUBJID\")) %&gt;%\n  mutate(\n    ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), \"All non-fatal AEs resolved\"),\n    NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), \"At least one non-fatal unresolved or ongoing AE\")\n  )\n\nadae &lt;- adae %&gt;%\n  mutate(\n    AEDECOD = as.character(AEDECOD),\n    WD = with_label(AEACN == \"DRUG WITHDRAWN\", \"AE that led to study drug withdrawal\"),\n    DSM = with_label(AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"AE that led to study drug dose modified/interrupted\"),\n    CONTRT = with_label(AECONTRT == \"Y\", \"AE that required treatment\"),\n    SER = with_label(AESER == \"Y\", \"Serious AE\"),\n    REL = with_label(AEREL == \"Y\", \"Related AE\"),\n    ALL_RESOLVED_WD = with_label(WD == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that led to study drug withdrawal\"),\n    ALL_RESOLVED_DSM = with_label(DSM == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that led to study drug dose modified/interrupted\"),\n    ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that required treatment\"),\n    NOT_RESOLVED_WD = with_label(WD == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that led to study drug withdrawal\"),\n    NOT_RESOLVED_DSM = with_label(DSM == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that led to study drug dose modified/interrupted\"),\n    NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that required treatment\"),\n    SERWD = with_label(AESER == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Serious AE that led to study drug withdrawal\"),\n    SERCONTRT = with_label(AECONTRT == \"Y\" & AESER == \"Y\", \"Serious AE that required treatment\"),\n    SERDSM = with_label(\n      AESER == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Serious AE that led to study drug dose modified/interrupted\"\n    ),\n    RELWD = with_label(\n      AEREL == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Related AE that led to study drug withdrawal\"\n    ),\n    RELDSM = with_label(\n      AEREL == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Related AE that led to study drug dose modified/interrupted\"\n    ),\n    RELCONTRT = with_label(AECONTRT == \"Y\" & AEREL == \"Y\", \"Related AE that required treatment\"),\n    RELSER = with_label(AESER == \"Y\" & AEREL == \"Y\", \"Serious related AE\")\n  )\n\naesi_vars &lt;- c(\n  \"WD\", \"DSM\", \"CONTRT\", \"ALL_RESOLVED_WD\", \"ALL_RESOLVED_DSM\", \"ALL_RESOLVED_CONTRT\",\n  \"NOT_RESOLVED_WD\", \"NOT_RESOLVED_DSM\", \"NOT_RESOLVED_CONTRT\", \"SER\", \"SERWD\", \"SERDSM\",\n  \"SERCONTRT\", \"REL\", \"RELWD\", \"RELDSM\", \"RELCONTRT\", \"RELSER\"\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADAE\", adae, code = 'ADAE &lt;- synthetic_cdisc_dataset(\"latest\", \"adae\")\n      ADAE &lt;- filter(ADAE, ANL01FL == \"Y\" & SAFFL == \"Y\")\n      not_resolved &lt;- ADAE %&gt;%\n      filter(!(AEOUT %in% c(\"RECOVERED/RESOLVED\", \"FATAL\", \"RECOVERED/RESOLVED WITH SEQUELAE\"))) %&gt;%\n      distinct(USUBJID) %&gt;% mutate(NOT_RESOLVED = \"Y\")\n\n    ADAE &lt;- ADAE %&gt;%\n      left_join(not_resolved, by = c(\"USUBJID\")) %&gt;%\n      mutate(\n        ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), \"All non-fatal AEs resolved\"),\n        NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), \"At least one non-fatal unresolved or ongoing AE\")\n      )\n\n    ADAE &lt;- ADAE %&gt;%\n      mutate(\n        AEDECOD = as.character(AEDECOD),\n        WD = with_label(AEACN == \"DRUG WITHDRAWN\", \"AE that led to study drug withdrawal\"),\n        DSM = with_label(AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"AE that led to study drug dose modified/interrupted\"),\n        CONTRT = with_label(AECONTRT == \"Y\", \"AE that required treatment\"),\n        SER = with_label(AESER == \"Y\", \"Serious AE\"),\n        REL = with_label(AEREL == \"Y\", \"Related AE\"),\n        ALL_RESOLVED_WD = with_label(WD == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that led to study drug withdrawal\"),\n        ALL_RESOLVED_DSM = with_label(DSM == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that led to study drug dose modified/interrupted\"),\n        ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE & ALL_RESOLVED == TRUE, \"Resolved AE that required treatment\"),\n        NOT_RESOLVED_WD = with_label(WD == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that led to study drug withdrawal\"),\n        NOT_RESOLVED_DSM = with_label(DSM == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that led to study drug dose modified/interrupted\"),\n        NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE & NOT_RESOLVED == TRUE, \"Unresolved AE that required treatment\"),\n        SERWD = with_label(AESER == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Serious AE that led to study drug withdrawal\"),\n        SERCONTRT = with_label(AECONTRT == \"Y\" & AESER == \"Y\", \"Serious AE that required treatment\"),\n        SERDSM = with_label(\n          AESER == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Serious AE that led to study drug dose modified/interrupted\"\n        ),\n        RELWD = with_label(\n          AEREL == \"Y\" & AEACN == \"DRUG WITHDRAWN\", \"Related AE that led to study drug withdrawal\"\n        ),\n        RELDSM = with_label(\n          AEREL == \"Y\" & AEACN %in% c(\"DRUG INTERRUPTED\", \"DOSE INCREASED\", \"DOSE REDUCED\"), \"Related AE that led to study drug dose modified/interrupted\"\n        ),\n        RELCONTRT = with_label(AECONTRT == \"Y\" & AEREL == \"Y\", \"Related AE that required treatment\"),\n        RELSER = with_label(AESER == \"Y\" & AEREL == \"Y\", \"Serious related AE\")\n      )'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_events_summary(\n      label = \"Adverse Events Summary\",\n      dataname = \"ADAE\",\n      arm_var = choices_selected(\n        choices = variable_choices(\"ADSL\", c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      flag_var_anl = choices_selected(\n        choices = variable_choices(\"ADAE\", aesi_vars),\n        selected = aesi_vars[1],\n        keep_order = TRUE,\n        fixed = FALSE\n      ),\n      add_total = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:23:38.8184 pid:11488 token:[] teal.modules.clinical Initializing tm_t_events_summary\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] scda_0.1.6                   dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ADA/adat04a.html",
+    "href": "tables/ADA/adat04a.html",
+    "title": "ADAT04A",
+    "section": "",
+    "text": "Data Setup\nSummary of Treatment Emergent NAbs\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\nlibrary(tibble)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\")\n\ncombodf &lt;- tribble(\n  ~valname, ~label, ~levelcombo, ~exargs,\n  \"all_X\", \"All Drug X\", c(\"A: Drug X\", \"C: Combination\"), list(),\n  \"all_pt\", \"All Patients\", c(\"A: Drug X\", \"B: Placebo\", \"C: Combination\"), list()\n)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\n# Baseline Pts\nadab_b &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL == \"Y\",\n    ADABLPFL == \"Y\",\n    PARAM %in% c(\n      \"ADA interpreted per sample result\",\n      \"NAB interpreted per sample result\"\n    )\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU) %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate(\n    across(\n      any_of(c(\n        \"ADA interpreted per sample result\",\n        \"NAB interpreted per sample result\"\n      )),\n      as.logical\n    )\n  ) %&gt;%\n  mutate(\n    ADABLPFL = ADABLPFL == \"Y\",\n    PADABLPFL = if (exists(\"ADA interpreted per sample result\", where = .)) `ADA interpreted per sample result` == \"TRUE\" else FALSE,\n    PNABBLFL = if (exists(\"NAB interpreted per sample result\", where = .)) `NAB interpreted per sample result` == \"TRUE\" else FALSE,\n    NNABBLFL = if (exists(\"NAB interpreted per sample result\", where = .)) `NAB interpreted per sample result` == \"FALSE\" else FALSE\n  ) %&gt;%\n  var_relabel(\n    ADABLPFL = \"Baseline evaluable patients for ADA\",\n    PADABLPFL = \"Patients with a positive ADA sample at baseline\",\n    PNABBLFL = \"Patients with a positive NAb sample at baseline\",\n    NNABBLFL = \"Patient with no positive NAb samples at baseline\"\n  )\n\n# Post Baseline Treatment Enhanced NAb positive Pts\nadab_pb &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    ADPBLPFL == \"Y\",\n    PARAM %in% c(\n      \"ADA interpreted per sample result\",\n      \"Treatment Emergent - Positive, Neutralizing Antibody\",\n      \"Treatment induced ADA, Neutralizing Antibody\",\n      \"Treatment enhanced ADA, Neutralizing Antibody\",\n      \"NAB interpreted per sample result\",\n      \"Treatment unaffected, Neutralizing Antibody\"\n    )\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU, -ARRLT, -NRRLT) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate(\n    across(\n      any_of(c(\n        \"ADA interpreted per sample result\", \"NAB interpreted per sample result\",\n        \"Treatment Emergent - Positive, Neutralizing Antibody\",\n        \"Treatment induced ADA, Neutralizing Antibody\",\n        \"Treatment enhanced ADA, Neutralizing Antibody\",\n        \"Treatment unaffected, Neutralizing Antibody\"\n      )),\n      as.logical\n    )\n  ) %&gt;%\n  mutate(\n    ADPBLPFL = ADPBLPFL == \"Y\",\n    ADAPFL = if (exists(\"ADA interpreted per sample result\", where = .)) `ADA interpreted per sample result` == \"TRUE\" else FALSE,\n    TENABPFL = if (exists(\"Treatment Emergent - Positive, Neutralizing Antibody\", where = .)) `Treatment Emergent - Positive, Neutralizing Antibody` == \"TRUE\" else FALSE,\n    TINPBFL = if (exists(\"Treatment induced ADA, Neutralizing Antibody\", where = .)) `Treatment induced ADA, Neutralizing Antibody` == \"TRUE\" else FALSE,\n    TENPBFL = if (exists(\"Treatment enhanced ADA, Neutralizing Antibody\", where = .)) `Treatment enhanced ADA, Neutralizing Antibody` == \"TRUE\" else FALSE,\n    NABNFL = if (exists(\"NAB interpreted per sample result\", where = .)) `NAB interpreted per sample result` == \"FALSE\" else FALSE,\n    TUNPBFL = if (exists(\"Treatment unaffected, Neutralizing Antibody\", where = .)) `Treatment unaffected, Neutralizing Antibody` == \"TRUE\" else FALSE\n  ) %&gt;%\n  var_relabel(\n    ADPBLPFL = \"Post-baseline evaluable patients for ADA\",\n    ADAPFL = \"Patients positive for ADA\",\n    TENABPFL = \"Patients positive for Treatment Emergent NAb\",\n    TINPBFL = \"Treatment-induced NAb\",\n    TENPBFL = \"Treatment-enhanced NAb\",\n    NABNFL = \"Patients negative for NAb\",\n    TUNPBFL = \"Treatment unaffected\"\n  )\n\n\n\n\n\nCode# Layout for Baseline Prevalence of NAbs\nlyt_bl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"ADABLPFL\", \"PADABLPFL\"),\n    table_names = \"t1\",\n    .stats = \"count\",\n    var_labels = \"Baseline Prevalence of NAbs\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"PNABBLFL\",\n    table_names = \"t2\",\n    .indent_mods = 1L\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NNABBLFL\",\n    .stats = \"count\",\n    table_names = \"t3\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  )\n\n# Layout for incidence of NAbs\nlyt_pb &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"ADPBLPFL\", \"ADAPFL\"),\n    .stats = \"count\",\n    var_labels = \"Incidence of Treatment Emergent NAbs\",\n    show_labels = \"visible\",\n    table_names = \"tb1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"TENABPFL\",\n    table_names = \"tb2\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"TINPBFL\", \"TENPBFL\"),\n    .stats = \"count\",\n    table_names = \"tb3\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NABNFL\",\n    table_names = \"tb4\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"TUNPBFL\",\n    .stats = \"count\",\n    table_names = \"tb5\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  )\n\nresult_1 &lt;- build_table(lyt_bl, df = adab_b, alt_counts_df = adsl)\nresult_2 &lt;- build_table(lyt_pb, df = adab_pb, alt_counts_df = adsl)\n\n# Combine tables\nresult &lt;- rbind(result_1, result_2)\n\n# Change the column order\nresult &lt;- cbind_rtables(result[, 1], result[, 3]) %&gt;%\n  cbind_rtables(result[, 4]) %&gt;%\n  cbind_rtables(result[, 2]) %&gt;%\n  cbind_rtables(result[, 5])\n\nmain_title(result) &lt;- paste(\n  \"Baseline Prevalence and Incidence of Treatment Emergent NAbs\"\n)\nsubtitles(result) &lt;- paste(\"Protocol:\", unique(adab$PARCAT1)[1])\nmain_footer(result) &lt;- paste(\n  \"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s)\n  Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s)\n  Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample\n  Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample\n  Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.\nNumber of patients positive for Treatment Emergent NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have treatment-induced NAb or treatment-enhanced NAb during the study period.\nTreatment-induced = a patient with negative or missing baseline result(s) and at least one positive post-baseline result. Treatment-enhanced = a patient with positive result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\nNumber of patients negative for Treatment Emergent NAb = number of post-baseline evaluable patients with negative or missing baseline NAb result(s) and all negative post-baseline NAb results, or a patient who is NAb treatment unaffected.\nTreatment unaffected = A post-baseline evaluable patient with a positive result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing. For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.\"\n)\nresult\n\nBaseline Prevalence and Incidence of Treatment Emergent NAbs\nProtocol: A: Drug X Antibody\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                    A: Drug X   C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X\n                                                     (N=134)       (N=132)         (N=0)      (N=134)      (N=266)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nBaseline Prevalence of NAbs                                                                                         \n  Baseline evaluable patients for ADA                  134           132             0           0           266    \n  Patients with a positive ADA sample at baseline      63             64             0           0           127    \nPatients with a positive NAb sample at baseline         0             0             NA           NA           0     \nPatient with no positive NAb samples at baseline        0             0              0           0            0     \nIncidence of Treatment Emergent NAbs                                                                                \n  Post-baseline evaluable patients for ADA             134           132             0           0           266    \n  Patients positive for ADA                            66             59             0           0           125    \nPatients positive for Treatment Emergent NAb            0             0             NA           NA           0     \nTreatment-induced NAb                                   0             0              0           0            0     \nTreatment-enhanced NAb                                  0             0              0           0            0     \nPatients negative for NAb                               0             0             NA           NA           0     \nTreatment unaffected                                    0             0              0           0            0     \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nNAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s)\n  Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s)\n  Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample\n  Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample\n  Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.\nNumber of patients positive for Treatment Emergent NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have treatment-induced NAb or treatment-enhanced NAb during the study period.\nTreatment-induced = a patient with negative or missing baseline result(s) and at least one positive post-baseline result. Treatment-enhanced = a patient with positive result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.\nNumber of patients negative for Treatment Emergent NAb = number of post-baseline evaluable patients with negative or missing baseline NAb result(s) and all negative post-baseline NAb results, or a patient who is NAb treatment unaffected.\nTreatment unaffected = A post-baseline evaluable patient with a positive result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing. For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      \n[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ADA/adat04b.html",
+    "href": "tables/ADA/adat04b.html",
+    "title": "ADAT04B",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\nlibrary(tibble)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\")\n\ncombodf &lt;- tribble(\n  ~valname, ~label, ~levelcombo, ~exargs,\n  \"all_X\", \"All Drug X\", c(\"A: Drug X\", \"C: Combination\"), list(),\n  \"all_pt\", \"All Patients\", c(\"A: Drug X\", \"B: Placebo\", \"C: Combination\"), list()\n)\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\n# Baseline Pts\nadab_b &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL == \"Y\",\n    ADABLPFL == \"Y\",\n    PARAM %in% c(\n      \"ADA interpreted per sample result\",\n      \"NAB interpreted per sample result\"\n    )\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU) %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate(\n    across(\n      any_of(c(\n        \"ADA interpreted per sample result\",\n        \"NAB interpreted per sample result\"\n      )),\n      as.logical\n    )\n  ) %&gt;%\n  mutate(\n    ADABLPFL = ADABLPFL == \"Y\",\n    PADABLPFL = if (exists(\"ADA interpreted per sample result\", where = .)) `ADA interpreted per sample result` == \"TRUE\" else FALSE,\n    PNABBLFL = if (exists(\"NAB interpreted per sample result\", where = .)) `NAB interpreted per sample result` == \"TRUE\" else FALSE,\n    NNABBLFL = if (exists(\"NAB interpreted per sample result\", where = .)) `NAB interpreted per sample result` == \"FALSE\" else FALSE\n  ) %&gt;%\n  var_relabel(\n    ADABLPFL = \"Baseline evaluable patients for ADA\",\n    PADABLPFL = \"Patients with a positive ADA sample at baseline\",\n    PNABBLFL = \"Patients with a positive NAb sample at baseline\",\n    NNABBLFL = \"Patients with no positive NAb sample at baseline\"\n  )\n\n# Post-Baseline Evaluable Pts\nadab_pb_ada &lt;- df_explicit_na(adab) %&gt;%\n  filter(ADPBLPFL == \"Y\") %&gt;%\n  select(STUDYID, USUBJID, ARM, ACTARM, ADPBLPFL) %&gt;%\n  mutate(ADPBLPFL = ADPBLPFL == \"Y\") %&gt;%\n  distinct()\n\n# Post-Baseline ADA Positive Pts\nadab_pb_adap &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    PARAM == \"ADA interpreted per sample result\",\n    AVALC == \"POSITIVE\"\n  ) %&gt;%\n  mutate(ADAPFL = AVALC == \"POSITIVE\") %&gt;%\n  select(STUDYID, USUBJID, ARM, ACTARM, ADAPFL) %&gt;%\n  distinct()\n\n# Post-Baseline NAb Positive Pts\nadab_pb_nabp &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    PARAM == \"NAb interpreted per sample result\",\n    AVALC == \"POSITIVE\"\n  ) %&gt;%\n  mutate(NABPFL = AVALC == \"POSITIVE\") %&gt;%\n  select(STUDYID, USUBJID, ARM, ACTARM, NABPFL) %&gt;%\n  distinct()\n\n# Post-Baseline NAb Negative Pts\nadab_pb_nabn &lt;- df_explicit_na(adab) %&gt;%\n  filter(\n    ABLFL != \"Y\",\n    PARAM == \"NAb interpreted per sample result\",\n    AVALC == \"NEGATIVE\"\n  ) %&gt;%\n  rename(NABNFL = AVALC) %&gt;%\n  select(STUDYID, USUBJID, ARM, ACTARM, NABNFL) %&gt;%\n  distinct()\n\nmergecol &lt;- c(\"STUDYID\", \"USUBJID\", \"ARM\", \"ACTARM\")\n\nadab_pb &lt;- left_join(adab_pb_ada, adab_pb_adap, by = mergecol) %&gt;%\n  left_join(adab_pb_nabp, by = mergecol) %&gt;%\n  mutate(\n    NABNFL = ifelse(is.na(NABPFL), \"TRUE\", \"FALSE\"),\n    NABNFL = NABNFL == \"TRUE\"\n  ) %&gt;%\n  var_relabel(\n    ADPBLPFL = \"Post-baseline evaluable patients for ADA\",\n    ADAPFL = \"Patients positive for ADA\",\n    NABPFL = \"Patients positive for NAb\",\n    NABNFL = \"Patients negative for NAb\"\n  )\n\n\n\n\n\nCode# Layout for Baseline Prevalence of NAbs\nlyt_bl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"ADABLPFL\", \"PADABLPFL\"),\n    .stats = \"count\",\n    var_labels = \"Baseline Prevalence of NAbs\",\n    show_labels = \"visible\",\n    table_names = \"t1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"PNABBLFL\",\n    table_names = \"t2\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NNABBLFL\",\n    .stats = \"count\",\n    table_names = \"t3\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  )\n\n# Layout for incidence of NAbs\nlyt_pb &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_combo_levels(combodf)\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"ADPBLPFL\", \"ADAPFL\"),\n    .stats = \"count\",\n    var_labels = \"Incidence of NAbs\",\n    show_labels = \"visible\",\n    table_names = \"tb1\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NABPFL\",\n    table_names = \"tb2\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"NABNFL\",\n    .stats = \"count\",\n    table_names = \"tb3\",\n    .indent_mods = 1L,\n    show_labels = \"hidden\"\n  )\n\nresult_1 &lt;- build_table(lyt_bl, df = adab_b, alt_counts_df = adsl)\nresult_2 &lt;- build_table(lyt_pb, df = adab_pb, alt_counts_df = adsl)\n\n# Combine tables.\nresult &lt;- rbind(result_1, result_2)\n\n# Change the column order.\nresult &lt;- cbind_rtables(result[, 1], result[, 3]) %&gt;%\n  cbind_rtables(result[, 4]) %&gt;%\n  cbind_rtables(result[, 2]) %&gt;%\n  cbind_rtables(result[, 5])\n\nmain_title(result) &lt;- paste(\n  \"Baseline Prevalence and Incidence of Neutralizing Antibodies (NAbs)\"\n)\nsubtitles(result) &lt;- paste(\"Protocol:\", unique(adab$PARCAT1)[1])\nmain_footer(result) &lt;- paste(\n  \"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s) Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s) Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.\nNumber of patients positive for NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have at least one positive post-baseline NAb result during the study period. Number of patients negative for NAb = number of post-baseline evaluable patients with all negative post-baseline NAb results.\"\n)\nresult\n\nBaseline Prevalence and Incidence of Neutralizing Antibodies (NAbs)\nProtocol: A: Drug X Antibody\n\n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n                                                    A: Drug X   C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X\n                                                     (N=134)       (N=132)         (N=0)      (N=134)      (N=266)  \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nBaseline Prevalence of NAbs                                                                                         \n  Baseline evaluable patients for ADA                  134           132             0           0           266    \n  Patients with a positive ADA sample at baseline      63             64             0           0           127    \nPatients with a positive NAb sample at baseline         0             0             NA           NA           0     \nPatients with no positive NAb sample at baseline        0             0              0           0            0     \nIncidence of NAbs                                                                                                   \n  Post-baseline evaluable patients for ADA             134           132             0           0           266    \n  Patients positive for ADA                            66             59             0           0           125    \nPatients positive for NAb                               0             0             NA           NA           0     \nPatients negative for NAb                              134           132             0           0           266    \n————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\n\nNAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s) Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s) Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.\nNumber of patients positive for NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have at least one positive post-baseline NAb result during the study period. Number of patients negative for NAb = number of post-baseline evaluable patients with all negative post-baseline NAb results.\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      \n[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      \n[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        \n[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/ADA/adat02.html",
+    "href": "tables/ADA/adat02.html",
+    "title": "ADAT02",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(dplyr)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadab &lt;- synthetic_cdisc_dataset(\"latest\", \"adab\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadab &lt;- df_explicit_na(adab) %&gt;%\n  mutate(ADPBLPFL = \"Y\") %&gt;% # temp fix\n  filter(\n    ADPBLPFL == \"Y\",\n    !PARAM %in% c(\n      \"NAB interpreted per sample result\",\n      \"NAB Status of a patient\",\n      \"Treatment enhanced ADA\"\n    )\n  ) %&gt;%\n  select(-PARAMCD, -AVALC, -AVALU, -ARRLT, -NRRLT) %&gt;%\n  unique() %&gt;%\n  tidyr::pivot_wider(\n    names_from = PARAM,\n    values_from = AVAL\n  ) %&gt;%\n  mutate(\n    across(\n      any_of(c(\n        \"Treatment induced ADA\",\n        \"Transient ADA\",\n        \"Persistent ADA\"\n      )),\n      as.logical\n    )\n  ) %&gt;%\n  mutate(\n    ADPBLPFL = ADPBLPFL == \"Y\",\n    TI_ADA = if (exists(\"Treatment induced ADA\", where = .)) `Treatment induced ADA` else FALSE\n  ) %&gt;%\n  var_relabel(\n    ADPBLPFL = \"Post-baseline evaluable patients\",\n    TI_ADA = \"Treatment-induced ADA patients\"\n  )\n\nadab_ti &lt;- adab %&gt;%\n  filter(TI_ADA)\n\n\n\n\n\nCode# Layout for post-baseline evaluable patient variables from adab dataset.\nlyt_adab &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = drop_split_levels\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"ADPBLPFL\",\n    .stats = \"count\",\n    table_names = \"post_baseline\"\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = \"TI_ADA\"\n  )\n\n# Layout for treatment-induced patient variables from adab dataset.\nlyt_adab_ti &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = keep_split_levels(c(\"A: Drug X\", \"C: Combination\", \"&lt;Missing&gt;\")) # temp fix\n  ) %&gt;%\n  count_patients_with_flags(\n    \"USUBJID\",\n    flag_variables = c(\"Transient ADA\", \"Persistent ADA\"),\n    var_labels = \"Treatment-induced ADA patients with\",\n    show_labels = \"visible\"\n  ) %&gt;%\n  analyze_vars(\n    \"Time to onset of ADA\",\n    .stats = \"median\",\n    nested = FALSE,\n    .labels = c(median = \"Median time to onset of ADA (weeks)\")\n  ) %&gt;%\n  analyze_vars(\n    \"Antibody titer units\",\n    .stats = \"range\",\n    nested = FALSE,\n    .labels = c(range = \"ADA titer range (min - max)\")\n  )\n\nresult_adab &lt;- build_table(lyt_adab, df = adab, alt_counts_df = adsl)\nresult_adab_ti &lt;- build_table(lyt_adab_ti, df = adab_ti, alt_counts_df = adsl)\n\n# Combine tables.\ncol_info(result_adab) &lt;- col_info(result_adab_ti)\nresult &lt;- rbind(\n  result_adab,\n  result_adab_ti\n)\n\nmain_title(result) &lt;- paste(\n  \"Summary of Patients with Treatment-Induced ADA, PK Population\"\n)\nsubtitles(result) &lt;- paste(\"Protocol:\", unique(adab$PARCAT1)[1])\nmain_footer(result) &lt;- paste(\n  \"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic\n  Antibodies)\n  Treatment-induced ADA = negative or missing baseline.\n  ADA result(s) and at least one positive post-baseline ADA result.\n  Transient ADA = ADA positive result detected (a) at only one post-baseline\n  sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints\n  during treatment where the first and last ADA positive samples are separated\n  by a period of &lt; 16 weeks, irrespective of any negative samples in between.\n  Persistent ADA = ADA positive result detected (a) at the last post-baseline\n  sampling timepoint, OR (b) at 2 or more time points during treatment where\n  the first and last ADA positive samples are separated by a period ≥ 16\n  weeks, irrespective of any negative samples in between.\"\n)\nresult\n\nSummary of Patients with Treatment-Induced ADA, PK Population\nProtocol: A: Drug X Antibody\n\n—————————————————————————————————————————————————————————————————————————————\n                                      A: Drug X   C: Combination   &lt;Missing&gt; \n                                       (N=134)       (N=132)         (N=0)   \n—————————————————————————————————————————————————————————————————————————————\nPost-baseline evaluable patients         134           132            266    \nTreatment-induced ADA patients            0             0          64 (24.1%)\nTreatment-induced ADA patients with                                          \n  Transient ADA                          NA             NA             0     \n  Persistent ADA                         NA             NA             0     \nMedian time to onset of ADA (weeks)      NA             NA            0.1    \nADA titer range (min - max)              NA             NA             NA    \n—————————————————————————————————————————————————————————————————————————————\n\nADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic\n  Antibodies)\n  Treatment-induced ADA = negative or missing baseline.\n  ADA result(s) and at least one positive post-baseline ADA result.\n  Transient ADA = ADA positive result detected (a) at only one post-baseline\n  sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints\n  during treatment where the first and last ADA positive samples are separated\n  by a period of &lt; 16 weeks, irrespective of any negative samples in between.\n  Persistent ADA = ADA positive result detected (a) at the last post-baseline\n  sampling timepoint, OR (b) at 2 or more time points during treatment where\n  the first and last ADA positive samples are separated by a period ≥ 16\n  weeks, irrespective of any negative samples in between.\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] scda_0.1.6       dplyr_1.1.3      tern_0.9.0       rtables_0.6.3   \n[5] magrittr_2.0.3   formatters_0.5.2\n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       \n[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  \n[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 \n[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      \n[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt14.html",
+    "href": "tables/lab-results/lbt14.html",
+    "title": "LBT14",
+    "section": "",
+    "text": "Data Setup\nStandard Table (High)\nStandard Table (Low)\nTable Without Patients with  Missing Baseline (High)\nTable with Missing Baseline  Considered as Grade 0 (Low)\nTable with Fill-In of Grades\nteal App\nReproducibility\n\n\n\nPlease note that for each variant, the adlb dataset needs to be filtered on correct flags like WGRLOFL, WGRHIFL, et al., otherwise the layout function will not return the correct counts. There is an option to create a record for a lab test where no record is found at that visit. If you specified add_derived_type = \"PHANTOM\" & dtype_phantom_cond, you don’t have to use the h_adsl_adlb_merge_using_worst_flag function to preprocess your adlb dataset. Otherwise please follow the pre-processing steps below before applying the layout functions.\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\n# Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be\n# selected properly.\nadsl_f &lt;- adsl %&gt;% filter(SAFFL == \"Y\")\nadlb &lt;- adlb %&gt;% filter(SAFFL == \"Y\")\n\n\n\n\nNote that the worst laboratory flag (below WGRHIFL) must be selected appropriately in the pre-processing step. New grouping variables ATOXGR_GP (post-baseline) and BTOXGR_GP (baseline) are created to display the correct output.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- h_adsl_adlb_merge_using_worst_flag(adsl_f, adlb_f, worst_flag = c(\"WGRHIFL\" = \"Y\"))\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = factor(case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = factor(case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = \"Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    \"BTOXGR_GP\",\n    label_pos = \"topleft\",\n    split_label = \"    Baseline NCI-CTCAE Grade\",\n    indent_mod = 2L\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\"), unique_count_suffix = FALSE) %&gt;%\n  count_occurrences_by_grade(\"ATOXGR_GP\", denom = \"n\", drop = FALSE, .indent_mods = 3L) %&gt;%\n  append_topleft(\"              Post-baseline NCI-CTCAE Grade\") %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nParameter                                                                             \n      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination\n              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                  \n      Not High                                   134          134            132      \n              Not High                        134 (100%)   134 (100%)     132 (100%)  \nC-Reactive Protein Measurement                                                        \n      Not High                                   114          112            115      \n              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  \n              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  \n              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   \n              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  \n              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   \n      1                                           8            10             7       \n              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   \n              1                                   0         1 (0.7%)          0       \n              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   \n      2                                           2            6              7       \n              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   \n              1                                   0         1 (0.7%)       2 (1.5%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              4                                   0            0           1 (0.8%)   \n      3                                           7            4              3       \n              Not High                         3 (2.2%)        0           2 (1.5%)   \n              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   \n              2                                   0         1 (0.7%)          0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n      4                                           3            2              0       \n              Not High                         1 (0.7%)        0              0       \n              1                                   0         1 (0.7%)          0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)        0              0       \nImmunoglobulin A Measurement                                                          \n      Not High                                   119          116            113      \n              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  \n              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  \n              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  \n              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  \n              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   \n      1                                           5            4              2       \n              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              3                                   0         2 (1.5%)          0       \n      2                                           4            4              5       \n              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   \n              1                                1 (0.7%)        0           2 (1.5%)   \n              3                                1 (0.7%)        0              0       \n              4                                   0         1 (0.7%)          0       \n      3                                           4            5              11      \n              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   \n              1                                   0         1 (0.7%)       1 (0.8%)   \n              2                                1 (0.7%)        0              0       \n              3                                   0         2 (1.5%)       3 (2.3%)   \n              4                                   0         1 (0.7%)       1 (0.8%)   \n      4                                           2            5              1       \n              Not High                            0         3 (2.2%)       1 (0.8%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n\n\n\n\nNote that the worst laboratory flag (below WGRLOFL) must be selected appropriately in the pre-processing step. New grouping variables ATOXGR_GP (post-baseline) and BTOXGR_GP (baseline) are created to display the correct output.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRLOFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- h_adsl_adlb_merge_using_worst_flag(adsl_f, adlb_f, worst_flag = c(\"WGRLOFL\" = \"Y\"))\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = factor(case_when(\n      ATOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      ATOXGR == -1 ~ \"1\",\n      ATOXGR == -2 ~ \"2\",\n      ATOXGR == -3 ~ \"3\",\n      ATOXGR == -4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = factor(case_when(\n      BTOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      BTOXGR == -1 ~ \"1\",\n      BTOXGR == -2 ~ \"2\",\n      BTOXGR == -3 ~ \"3\",\n      BTOXGR == -4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = \"Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    \"BTOXGR_GP\",\n    label_pos = \"topleft\",\n    split_label = \"    Baseline NCI-CTCAE Grade\",\n    indent_mod = 2L\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\"), unique_count_suffix = FALSE) %&gt;%\n  count_occurrences_by_grade(\"ATOXGR_GP\", denom = \"n\", drop = FALSE, .indent_mods = 3L) %&gt;%\n  append_topleft(\"              Post-baseline NCI-CTCAE Grade\") %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nParameter                                                                             \n      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination\n              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                  \n      Not Low                                    113          117            123      \n              Not Low                         56 (41.8%)   55 (41.0%)     62 (47.0%)  \n              1                               11 (8.2%)     9 (6.7%)      15 (11.4%)  \n              2                               15 (11.2%)   23 (17.2%)     16 (12.1%)  \n              3                               15 (11.2%)   21 (15.7%)     13 (9.8%)   \n              4                               16 (11.9%)    9 (6.7%)      17 (12.9%)  \n      1                                           6            6              4       \n              Not Low                          3 (2.2%)     5 (3.7%)       3 (2.3%)   \n              1                                3 (2.2%)        0              0       \n              4                                   0         1 (0.7%)       1 (0.8%)   \n      2                                           8            5              1       \n              Not Low                          5 (3.7%)     3 (2.2%)          0       \n              1                                   0         1 (0.7%)          0       \n              2                                2 (1.5%)        0              0       \n              3                                   0         1 (0.7%)       1 (0.8%)   \n              4                                1 (0.7%)        0              0       \n      3                                           3            3              2       \n              Not Low                             0         1 (0.7%)          0       \n              1                                1 (0.7%)        0              0       \n              2                                1 (0.7%)        0           1 (0.8%)   \n              3                                1 (0.7%)     2 (1.5%)       1 (0.8%)   \n      4                                           4            3              2       \n              Not Low                          4 (3.0%)     1 (0.7%)       1 (0.8%)   \n              1                                   0         1 (0.7%)          0       \n              2                                   0         1 (0.7%)          0       \n              3                                   0            0           1 (0.8%)   \nC-Reactive Protein Measurement                                                        \n      Not Low                                    119          113            112      \n              Not Low                         41 (30.6%)   42 (31.3%)     50 (37.9%)  \n              1                               20 (14.9%)   18 (13.4%)     11 (8.3%)   \n              2                               24 (17.9%)   20 (14.9%)     14 (10.6%)  \n              3                               25 (18.7%)   18 (13.4%)     21 (15.9%)  \n              4                                9 (6.7%)    15 (11.2%)     16 (12.1%)  \n      1                                           3            5              9       \n              Not Low                          2 (1.5%)     2 (1.5%)       2 (1.5%)   \n              2                                   0         1 (0.7%)       3 (2.3%)   \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                   0         1 (0.7%)       4 (3.0%)   \n      2                                           5            9              2       \n              Not Low                          3 (2.2%)     4 (3.0%)       1 (0.8%)   \n              1                                1 (0.7%)     4 (3.0%)          0       \n              3                                   0         1 (0.7%)       1 (0.8%)   \n              4                                1 (0.7%)        0              0       \n      3                                           4            5              7       \n              Not Low                          1 (0.7%)     4 (3.0%)       2 (1.5%)   \n              1                                   0            0           1 (0.8%)   \n              2                                   0            0           1 (0.8%)   \n              3                                3 (2.2%)     1 (0.7%)       2 (1.5%)   \n              4                                   0            0           1 (0.8%)   \n      4                                           3            2              2       \n              Not Low                          3 (2.2%)     1 (0.7%)          0       \n              2                                   0         1 (0.7%)          0       \n              3                                   0            0           1 (0.8%)   \n              4                                   0            0           1 (0.8%)   \nImmunoglobulin A Measurement                                                          \n      Not Low                                    134          134            132      \n              Not Low                         134 (100%)   134 (100%)     132 (100%)  \n\n\n\n\nNote that missing baseline values are filtered out in the pre-processing step.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- h_adsl_adlb_merge_using_worst_flag(adsl_f, adlb_f, worst_flag = c(\"WGRHIFL\" = \"Y\"))\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  filter(BTOXGR != \"&lt;Missing&gt;\") %&gt;%\n  mutate(\n    ATOXGR_GP = factor(case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = factor(case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\"))\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = \"Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    \"BTOXGR_GP\",\n    label_pos = \"topleft\",\n    split_label = \"    Baseline NCI-CTCAE Grade\",\n    indent_mod = 2L\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\"), unique_count_suffix = FALSE) %&gt;%\n  count_occurrences_by_grade(\"ATOXGR_GP\", denom = \"n\", drop = FALSE, .indent_mods = 3L) %&gt;%\n  append_topleft(\"              Post-baseline NCI-CTCAE Grade\") %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nParameter                                                                             \n      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination\n              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                  \n      Not High                                   134          134            132      \n              Not High                        134 (100%)   134 (100%)     132 (100%)  \nC-Reactive Protein Measurement                                                        \n      Not High                                   114          112            115      \n              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  \n              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  \n              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   \n              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  \n              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   \n      1                                           8            10             7       \n              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   \n              1                                   0         1 (0.7%)          0       \n              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   \n      2                                           2            6              7       \n              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   \n              1                                   0         1 (0.7%)       2 (1.5%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              4                                   0            0           1 (0.8%)   \n      3                                           7            4              3       \n              Not High                         3 (2.2%)        0           2 (1.5%)   \n              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   \n              2                                   0         1 (0.7%)          0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n      4                                           3            2              0       \n              Not High                         1 (0.7%)        0              0       \n              1                                   0         1 (0.7%)          0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)        0              0       \nImmunoglobulin A Measurement                                                          \n      Not High                                   119          116            113      \n              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  \n              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  \n              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  \n              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  \n              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   \n      1                                           5            4              2       \n              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              3                                   0         2 (1.5%)          0       \n      2                                           4            4              5       \n              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   \n              1                                1 (0.7%)        0           2 (1.5%)   \n              3                                1 (0.7%)        0              0       \n              4                                   0         1 (0.7%)          0       \n      3                                           4            5              11      \n              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   \n              1                                   0         1 (0.7%)       1 (0.8%)   \n              2                                1 (0.7%)        0              0       \n              3                                   0         2 (1.5%)       3 (2.3%)   \n              4                                   0         1 (0.7%)       1 (0.8%)   \n      4                                           2            5              1       \n              Not High                            0         3 (2.2%)       1 (0.8%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n\n\n\n\nNote that when BTOXGR is missing, the grouping variable BTOXGR_GP now is \"Not Low\" instead of \"Missing\" compared to Standard Table (Low).\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRLOFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- h_adsl_adlb_merge_using_worst_flag(adsl_f, adlb_f, worst_flag = c(\"WGRLOFL\" = \"Y\"))\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = factor(case_when(\n      ATOXGR %in% c(0, 1, 2, 3, 4) ~ \"Not Low\",\n      ATOXGR == -1 ~ \"1\",\n      ATOXGR == -2 ~ \"2\",\n      ATOXGR == -3 ~ \"3\",\n      ATOXGR == -4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\"))\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = factor(case_when(\n      BTOXGR %in% c(0, 1, 2, 3, 4, \"&lt;Missing&gt;\") ~ \"Not Low\",\n      BTOXGR == -1 ~ \"1\",\n      BTOXGR == -2 ~ \"2\",\n      BTOXGR == -3 ~ \"3\",\n      BTOXGR == -4 ~ \"4\"\n    ), levels = c(\"Not Low\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = \"Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    \"BTOXGR_GP\",\n    label_pos = \"topleft\",\n    split_label = \"    Baseline NCI-CTCAE Grade\",\n    indent_mod = 2L\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\"), unique_count_suffix = FALSE) %&gt;%\n  count_occurrences_by_grade(\"ATOXGR_GP\", denom = \"n\", drop = FALSE, .indent_mods = 3L) %&gt;%\n  append_topleft(\"              Post-baseline NCI-CTCAE Grade\") %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f) %&gt;%\n  prune_table()\n\nresult\n\nParameter                                                                             \n      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination\n              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                  \n      Not Low                                    113          117            123      \n              Not Low                         56 (41.8%)   55 (41.0%)     62 (47.0%)  \n              1                               11 (8.2%)     9 (6.7%)      15 (11.4%)  \n              2                               15 (11.2%)   23 (17.2%)     16 (12.1%)  \n              3                               15 (11.2%)   21 (15.7%)     13 (9.8%)   \n              4                               16 (11.9%)    9 (6.7%)      17 (12.9%)  \n      1                                           6            6              4       \n              Not Low                          3 (2.2%)     5 (3.7%)       3 (2.3%)   \n              1                                3 (2.2%)        0              0       \n              4                                   0         1 (0.7%)       1 (0.8%)   \n      2                                           8            5              1       \n              Not Low                          5 (3.7%)     3 (2.2%)          0       \n              1                                   0         1 (0.7%)          0       \n              2                                2 (1.5%)        0              0       \n              3                                   0         1 (0.7%)       1 (0.8%)   \n              4                                1 (0.7%)        0              0       \n      3                                           3            3              2       \n              Not Low                             0         1 (0.7%)          0       \n              1                                1 (0.7%)        0              0       \n              2                                1 (0.7%)        0           1 (0.8%)   \n              3                                1 (0.7%)     2 (1.5%)       1 (0.8%)   \n      4                                           4            3              2       \n              Not Low                          4 (3.0%)     1 (0.7%)       1 (0.8%)   \n              1                                   0         1 (0.7%)          0       \n              2                                   0         1 (0.7%)          0       \n              3                                   0            0           1 (0.8%)   \nC-Reactive Protein Measurement                                                        \n      Not Low                                    119          113            112      \n              Not Low                         41 (30.6%)   42 (31.3%)     50 (37.9%)  \n              1                               20 (14.9%)   18 (13.4%)     11 (8.3%)   \n              2                               24 (17.9%)   20 (14.9%)     14 (10.6%)  \n              3                               25 (18.7%)   18 (13.4%)     21 (15.9%)  \n              4                                9 (6.7%)    15 (11.2%)     16 (12.1%)  \n      1                                           3            5              9       \n              Not Low                          2 (1.5%)     2 (1.5%)       2 (1.5%)   \n              2                                   0         1 (0.7%)       3 (2.3%)   \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                   0         1 (0.7%)       4 (3.0%)   \n      2                                           5            9              2       \n              Not Low                          3 (2.2%)     4 (3.0%)       1 (0.8%)   \n              1                                1 (0.7%)     4 (3.0%)          0       \n              3                                   0         1 (0.7%)       1 (0.8%)   \n              4                                1 (0.7%)        0              0       \n      3                                           4            5              7       \n              Not Low                          1 (0.7%)     4 (3.0%)       2 (1.5%)   \n              1                                   0            0           1 (0.8%)   \n              2                                   0            0           1 (0.8%)   \n              3                                3 (2.2%)     1 (0.7%)       2 (1.5%)   \n              4                                   0            0           1 (0.8%)   \n      4                                           3            2              2       \n              Not Low                          3 (2.2%)     1 (0.7%)          0       \n              2                                   0         1 (0.7%)          0       \n              3                                   0            0           1 (0.8%)   \n              4                                   0            0           1 (0.8%)   \nImmunoglobulin A Measurement                                                          \n      Not Low                                    134          134            132      \n              Not Low                         134 (100%)   134 (100%)     132 (100%)  \n\n\n\n\nPre-processing is the same as Standard Table (High), but in order to keep all levels, prune_table() is not applied.\n\nCodeadlb_f &lt;- adlb %&gt;% filter(WGRHIFL == \"Y\")\n\n# Please note the step below can be skipped if you are using DTYPE PHANTOM\nadlb_out &lt;- h_adsl_adlb_merge_using_worst_flag(adsl_f, adlb_f, worst_flag = c(\"WGRHIFL\" = \"Y\"))\n\n# Create new grouping variables ATOXGR_GP, BTOXGR_GP\nadlb_out &lt;- adlb_out %&gt;%\n  mutate(\n    ATOXGR_GP = factor(case_when(\n      ATOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      ATOXGR == 1 ~ \"1\",\n      ATOXGR == 2 ~ \"2\",\n      ATOXGR == 3 ~ \"3\",\n      ATOXGR == 4 ~ \"4\",\n      ATOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  ) %&gt;%\n  mutate(\n    BTOXGR_GP = factor(case_when(\n      BTOXGR %in% c(0, -1, -2, -3, -4) ~ \"Not High\",\n      BTOXGR == 1 ~ \"1\",\n      BTOXGR == 2 ~ \"2\",\n      BTOXGR == 3 ~ \"3\",\n      BTOXGR == 4 ~ \"4\",\n      BTOXGR == \"&lt;Missing&gt;\" ~ \"Missing\"\n    ), levels = c(\"Not High\", \"1\", \"2\", \"3\", \"4\", \"Missing\"))\n  )\n\nresult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\n    \"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = \"Parameter\"\n  ) %&gt;%\n  split_rows_by(\n    \"BTOXGR_GP\",\n    label_pos = \"topleft\",\n    split_label = \"    Baseline NCI-CTCAE Grade\",\n    indent_mod = 2L\n  ) %&gt;%\n  summarize_num_patients(var = \"USUBJID\", .stats = c(\"unique_count\"), unique_count_suffix = FALSE) %&gt;%\n  count_occurrences_by_grade(\"ATOXGR_GP\", denom = \"n\", drop = FALSE, .indent_mods = 3L) %&gt;%\n  append_topleft(\"              Post-baseline NCI-CTCAE Grade\") %&gt;%\n  build_table(df = adlb_out, alt_counts_df = adsl_f)\n\nresult\n\nParameter                                                                             \n      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination\n              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                  \n      Not High                                   134          134            132      \n              Not High                        134 (100%)   134 (100%)     132 (100%)  \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      1                                           0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      2                                           0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      3                                           0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      4                                           0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      Missing                                     0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \nC-Reactive Protein Measurement                                                        \n      Not High                                   114          112            115      \n              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  \n              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  \n              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   \n              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  \n              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   \n              Missing                             0            0              0       \n      1                                           8            10             7       \n              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   \n              1                                   0         1 (0.7%)          0       \n              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   \n              Missing                             0            0              0       \n      2                                           2            6              7       \n              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   \n              1                                   0         1 (0.7%)       2 (1.5%)   \n              2                                1 (0.7%)     1 (0.7%)          0       \n              3                                   0            0              0       \n              4                                   0            0           1 (0.8%)   \n              Missing                             0            0              0       \n      3                                           7            4              3       \n              Not High                         3 (2.2%)        0           2 (1.5%)   \n              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   \n              2                                   0         1 (0.7%)          0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n              Missing                             0            0              0       \n      4                                           3            2              0       \n              Not High                         1 (0.7%)        0              0       \n              1                                   0         1 (0.7%)          0       \n              2                                   0            0              0       \n              3                                1 (0.7%)     1 (0.7%)          0       \n              4                                1 (0.7%)        0              0       \n              Missing                             0            0              0       \n      Missing                                     0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \nImmunoglobulin A Measurement                                                          \n      Not High                                   119          116            113      \n              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  \n              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  \n              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  \n              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  \n              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   \n              Missing                             0            0              0       \n      1                                           5            4              2       \n              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   \n              1                                   0            0              0       \n              2                                1 (0.7%)     1 (0.7%)          0       \n              3                                   0         2 (1.5%)          0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n      2                                           4            4              5       \n              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   \n              1                                1 (0.7%)        0           2 (1.5%)   \n              2                                   0            0              0       \n              3                                1 (0.7%)        0              0       \n              4                                   0         1 (0.7%)          0       \n              Missing                             0            0              0       \n      3                                           4            5              11      \n              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   \n              1                                   0         1 (0.7%)       1 (0.8%)   \n              2                                1 (0.7%)        0              0       \n              3                                   0         2 (1.5%)       3 (2.3%)   \n              4                                   0         1 (0.7%)       1 (0.8%)   \n              Missing                             0            0              0       \n      4                                           2            5              1       \n              Not High                            0         3 (2.2%)       1 (0.8%)   \n              1                                   0            0              0       \n              2                                1 (0.7%)     1 (0.7%)          0       \n              3                                   0            0              0       \n              4                                1 (0.7%)     1 (0.7%)          0       \n              Missing                             0            0              0       \n      Missing                                     0            0              0       \n              Not High                            0            0              0       \n              1                                   0            0              0       \n              2                                   0            0              0       \n              3                                   0            0              0       \n              4                                   0            0              0       \n              Missing                             0            0              0       \n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", adlb,\n      code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_shift_by_grade(\n      label = \"Grade Laboratory Abnormality Table\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = \"ALT\"\n      ),\n      worst_flag_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"WGRLOVFL\", \"WGRLOFL\", \"WGRHIVFL\", \"WGRHIFL\")),\n        selected = c(\"WGRHIFL\")\n      ),\n      worst_flag_indicator = choices_selected(\n        value_choices(adlb, \"WGRLOVFL\"),\n        selected = \"Y\", fixed = TRUE\n      ),\n      anl_toxgrade_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"ATOXGR\")),\n        selected = c(\"ATOXGR\"),\n        fixed = TRUE\n      ),\n      base_toxgrade_var = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"BTOXGR\")),\n        selected = c(\"BTOXGR\"),\n        fixed = TRUE\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:25:36.8336 pid:11943 token:[] teal.modules.clinical Initializing tm_t_shift_by_grade\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt11.html",
+    "href": "tables/lab-results/lbt11.html",
+    "title": "LBT11",
+    "section": "",
+    "text": "Data Setup\nTime-To-Event Summary\nTime-To-Event Summary  Selecting Sections to Display\nTime-To-Event Summary  with Stratified Analysis\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsaftte &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadsaftte &lt;- df_explicit_na(adsaftte)\n\nadsl_safl &lt;- dplyr::filter(adsl, .data$SAFFL == \"Y\")\n\nanl &lt;- adsaftte %&gt;%\n  dplyr::filter(\n    SAFFL == \"Y\",\n    PARAMCD == \"HYSTTEUL\"\n  ) %&gt;%\n  dplyr::mutate(\n    AVAL = .data$AVAL * dplyr::case_when( # convert to days, if possible\n      .data$AVALU == \"WEEKS\" ~ 7,\n      .data$AVALU == \"MONTHS\" ~ 30.4375,\n      .data$AVALU == \"YEARS\" ~ 365,\n      TRUE ~ 1\n    ),\n    AVALU = factor(dplyr::case_when(\n      .data$AVALU %in% c(\"WEEKS\", \"MONTHS\", \"YEARS\") ~ factor(\"DAYS\"),\n      TRUE ~ .data$AVALU\n    ), levels = \"DAYS\"),\n    is_event = CNSR == 0, # this will be a LLT event\n    event_grp = factor(\n      dplyr::case_when(\n        CNSR == 0 ~ \"Patients with LLT event (%)\",\n        CNSR == 1 ~ \"Patients without LLT event (%)\"\n      ),\n      levels = c(\n        \"Patients with LLT event (%)\",\n        \"Patients without LLT event (%)\"\n      )\n    )\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Unstratified Analysis\",\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B            ARM C    \n                                    (N=134)         (N=134)          (N=132)   \n———————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   \nPatients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) \nTime to 1st LLT Event (DAYS)                                                   \n  Median                              NA               NA             728.0    \n    95% CI                            NA          (724.0, NA)          NA      \n  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 \n  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 \n  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0\nUnstratified Analysis                                                          \n  p-value (log-rank)                                 0.0295          0.1687    \n  Hazard Ratio                                        0.43            0.58     \n  95% CI                                          (0.19, 0.94)    (0.26, 1.27) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B            ARM C    \n                                    (N=134)         (N=134)          (N=132)   \n———————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   \nPatients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) \nTime to 1st LLT Event (DAYS)                                                   \n  Median                              NA               NA             728.0    \n    95% CI                            NA          (724.0, NA)          NA      \n  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 \n  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 \n  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0\n\n\n\n\n\nCodestrata &lt;- c(\"RACE\", \"SEX\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Unstratified Analysis\",\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = paste0(\"Stratified By: \", paste(strata, collapse = \", \")),\n    strat = strata,\n    table_names = \"coxph_stratified\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B            ARM C    \n                                    (N=134)         (N=134)          (N=132)   \n———————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   \nPatients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) \nTime to 1st LLT Event (DAYS)                                                   \n  Median                              NA               NA             728.0    \n    95% CI                            NA          (724.0, NA)          NA      \n  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 \n  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 \n  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0\nUnstratified Analysis                                                          \n  p-value (log-rank)                                 0.0295          0.1687    \n  Hazard Ratio                                        0.43            0.58     \n  95% CI                                          (0.19, 0.94)    (0.26, 1.27) \nStratified By: RACE, SEX                                                       \n  p-value (log-rank)                                 0.0858          0.1605    \n  Hazard Ratio                                        0.51            0.57     \n  95% CI                                          (0.23, 1.12)    (0.26, 1.26) \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsaftte &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadsaftte &lt;- df_explicit_na(adsaftte)\n\nadsl &lt;- dplyr::filter(adsl, .data$SAFFL == \"Y\")\nadsaftte &lt;- dplyr::filter(adsaftte, .data$SAFFL == \"Y\")\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == \"Y\")'\n    ),\n    cdisc_dataset(\n      \"ADSAFTTE\",\n      adsaftte,\n      keys = c(\"STUDYID\", \"USUBJID\", \"PARAMCD\"),\n      code = 'ADSAFTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == \"Y\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_tte(\n      label = \"Time To LLT Event Table\",\n      dataname = \"ADSAFTTE\",\n      arm_var = choices_selected(\n        variable_choices(adsl, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adsaftte, \"PARAMCD\", \"PARAM\"),\n        \"HYSTTEUL\"\n      ),\n      strata_var = choices_selected(\n        variable_choices(adsl, c(\"RACE\", \"SEX\")),\n        c(\"RACE\", \"SEX\")\n      ),\n      time_points = choices_selected(0, NULL),\n      event_desc_var = choices_selected(\"EVNTDESC\", \"EVNTDESC\", fixed = TRUE)\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:27:24.6782 pid:12139 token:[] teal.modules.clinical Initializing tm_t_tte\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt15.html",
+    "href": "tables/lab-results/lbt15.html",
+    "title": "LBT15",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable Modifying Cut Point\nteal App\nReproducibility\n\n\n\nBecause the scda dataset adlb doesn’t have the PARCAT1 variable, this variable is created from LBCAT in pre-processing.\nadlb &lt;- adlb %&gt;%\nmutate(\nPARAM = with_label(.data$PARAM, “Laboratory Test”),\nANRIND = with_label(.data$ANRIND, “Direction of Abnormality”)\n)\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\nlibrary(forcats)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb &lt;- adlb %&gt;%\n  mutate(\n    PARAM = with_label(.data$PARAM, \"Laboratory Test\"),\n    ANRIND = with_label(.data$ANRIND, \"Direction of Abnormality\")\n  ) %&gt;%\n  mutate(\n    PARCAT1 = LBCAT\n  ) %&gt;%\n  mutate(\n    ANRIND = fct_collapse(.data$ATOXGR,\n      \"LOW\" = c(\"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n      \"HIGH\" = c(\"3\", \"4\")\n    ),\n    BNRIND = fct_collapse(.data$BTOXGR,\n      \"LOW\" = c(\"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n      \"HIGH\" = c(\"3\", \"4\")\n    ),\n    PARCAT1 = LBCAT\n  ) %&gt;%\n  filter(ONTRTFL == \"Y\")\n\n\nadlb_alt_cut &lt;- adlb %&gt;%\n  mutate(\n    ANRIND = fct_collapse(.data$ATOXGR,\n      \"LOW\" = c(\"-2\", \"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-1\", \"0\", \"1\"),\n      \"HIGH\" = c(\"2\", \"3\", \"4\")\n    ),\n    BNRIND = fct_collapse(.data$BTOXGR,\n      \"LOW\" = c(\"-2\", \"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-1\", \"0\", \"1\"),\n      \"HIGH\" = c(\"2\", \"3\", \"4\")\n    )\n  ) %&gt;%\n  filter(ONTRTFL == \"Y\")\n\nadlb &lt;- adlb %&gt;% var_relabel(\n  PARCAT1 = \"Category for Lab Test\",\n  PARAM = \"Parameter\"\n)\n\n\n\n\n\nCode# Argument exclude_base_abn must be TRUE to include patients with normal or abnormal in the opposite direction in the denom\n# So for \"High\" direction, subjects with baseline grade 3-4 are not in the denom.\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  split_rows_by(\"PARCAT1\", split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb$PARCAT1)) %&gt;%\n  split_rows_by(\"PARAM\", split_fun = drop_split_levels, label_pos = \"topleft\", split_label = obj_label(adlb$PARAM)) %&gt;%\n  count_abnormal(\n    var = \"ANRIND\",\n    abnormal = list(Low = \"LOW\", High = \"HIGH\"),\n    variables = list(id = \"USUBJID\", baseline = \"BNRIND\"),\n    exclude_base_abn = TRUE,\n    .indent_mods = 4L\n  ) %&gt;%\n  append_topleft(\"            Direction of Abnormality\")\n\nresult &lt;- build_table(lyt, adlb, alt_counts_df = adsl)\nresult\n\nCategory for Lab Test                                                                                      \n  Parameter                                A: Drug X        B: Placebo     C: Combination    All Patients  \n            Direction of Abnormality        (N=134)          (N=134)          (N=132)           (N=400)    \n———————————————————————————————————————————————————————————————————————————————————————————————————————————\nCHEMISTRY                                                                                                  \n  Alanine Aminotransferase Measurement                                                                     \n            Low                          32/127 (25.2%)    32/128 (25%)     32/128 (25%)    96/383 (25.1%) \n            High                             0/134            0/134            0/132             0/400     \n  C-Reactive Protein Measurement                                                                           \n            Low                          36/127 (28.3%)   36/127 (28.3%)   42/123 (34.1%)   114/377 (30.2%)\n            High                         34/124 (27.4%)   33/128 (25.8%)    31/129 (24%)    98/381 (25.7%) \nIMMUNOLOGY                                                                                                 \n  Immunoglobulin A Measurement                                                                             \n            Low                              0/134            0/134            0/132             0/400     \n            High                         33/128 (25.8%)   32/124 (25.8%)   28/120 (23.3%)    93/372 (25%)  \n\n\n\n\n\nCoderesult &lt;- build_table(lyt, adlb_alt_cut, alt_counts_df = adsl)\nresult\n\nCategory for Lab Test                                                                                      \n  Parameter                                A: Drug X        B: Placebo     C: Combination    All Patients  \n            Direction of Abnormality        (N=134)          (N=134)          (N=132)           (N=400)    \n———————————————————————————————————————————————————————————————————————————————————————————————————————————\nCHEMISTRY                                                                                                  \n  Alanine Aminotransferase Measurement                                                                     \n            Low                          46/119 (38.7%)   54/123 (43.9%)    47/127 (37%)    147/369 (39.8%)\n            High                             0/134            0/134            0/132             0/400     \n  C-Reactive Protein Measurement                                                                           \n            Low                          59/122 (48.4%)   56/118 (47.5%)   58/121 (47.9%)   173/361 (47.9%)\n            High                         54/122 (44.3%)   46/122 (37.7%)   44/122 (36.1%)   144/366 (39.3%)\nIMMUNOLOGY                                                                                                 \n  Immunoglobulin A Measurement                                                                             \n            Low                              0/134            0/134            0/132             0/400     \n            High                         47/124 (37.9%)    54/120 (45%)    47/115 (40.9%)   148/359 (41.2%)\n\n\n\n\nThe current module tm_t_abnormality is only displaying rows that are not all-zero, so the result could be a little different from static output where all-zero rows can be shown.\n\nCodelibrary(teal.modules.clinical)\nlibrary(forcats)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  mutate(\n    ANRIND = fct_collapse(ATOXGR,\n      \"LOW\" = c(\"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n      \"HIGH\" = c(\"3\", \"4\")\n    ),\n    BNRIND = fct_collapse(.data$BTOXGR,\n      \"LOW\" = c(\"-3\", \"-4\"),\n      \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n      \"HIGH\" = c(\"3\", \"4\")\n    )\n  ) %&gt;%\n  filter(ONTRTFL == \"Y\") %&gt;%\n  var_relabel(ANRIND = \"Direction of Abnormality\")\n\n\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", adlb, code = '\n                  ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n                    mutate(\n                      ANRIND = fct_collapse(ATOXGR,\n                                                \"LOW\" = c(\"-3\", \"-4\"),\n                                                \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n                                                \"HIGH\" = c(\"3\", \"4\")\n                      ),\n                      BNRIND = fct_collapse(BTOXGR,\n                                                \"LOW\" = c(\"-3\", \"-4\"),\n                                                \"MODERATE/NORMAL\" = c(\"-2\", \"-1\", \"0\", \"1\", \"2\"),\n                                                \"HIGH\" = c(\"3\", \"4\")\n                      )\n                    ) %&gt;%\n                    filter(ONTRTFL == \"Y\") %&gt;%\n                    var_relabel(ANRIND = \"Direction of Abnormality\")\n                '),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_abnormality(\n      label = \"Abnormality Table\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"PARAM\")),\n        selected = c(\"PARAM\"),\n        keep_order = TRUE\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adlb, subset = \"ANRIND\"),\n        selected = \"ANRIND\",\n        fixed = TRUE\n      ),\n      baseline_var = choices_selected(\n        choices = variable_choices(adlb, subset = \"BNRIND\"),\n        selected = \"BNRIND\",\n        fixed = TRUE\n      ),\n      abnormal = list(Low = \"LOW\", High = \"HIGH\"),\n      exclude_base_abn = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:28:13.4481 pid:12289 token:[] teal.modules.clinical Initializing tm_t_abnormality\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] forcats_1.0.0                dplyr_1.1.3                 \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n[13] scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt04.html",
+    "href": "tables/lab-results/lbt04.html",
+    "title": "LBT04",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\nadlb_f &lt;- adlb %&gt;%\n  filter(ONTRTFL == \"Y\", ANRIND != \"&lt;Missing&gt;\") %&gt;%\n  var_relabel(\n    PARAM = \"Laboratory Test\",\n    ANRIND = \"Direction of Abnormality\"\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARAM\",\n    split_fun = drop_split_levels,\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb_f$PARAM)\n  ) %&gt;%\n  count_abnormal(\n    var = \"ANRIND\",\n    abnormal = list(Low = c(\"LOW\", \"LOW LOW\"), High = c(\"HIGH\", \"HIGH HIGH\")),\n    exclude_base_abn = TRUE\n  ) %&gt;%\n  append_varlabels(adlb_f, \"ANRIND\", indent = 1L)\n\nresult &lt;- build_table(lyt = lyt, df = adlb_f, alt_counts_df = adsl)\n\nresult\n\nLaboratory Test                          A: Drug X        B: Placebo     C: Combination\n  Direction of Abnormality                (N=134)          (N=134)          (N=132)    \n———————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                   \n  Low                                  57/113 (50.4%)    62/117 (53%)    61/123 (49.6%)\n  High                                     0/134            0/134            0/132     \nC-Reactive Protein Measurement                                                         \n  Low                                  78/119 (65.5%)   71/113 (62.8%)   62/112 (55.4%)\n  High                                 69/114 (60.5%)   57/112 (50.9%)   58/115 (50.4%)\nImmunoglobulin A Measurement                                                           \n  Low                                      0/134            0/134            0/132     \n  High                                 64/119 (53.8%)   62/116 (53.4%)   62/113 (54.9%)\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n  var_relabel(PARAM = \"Laboratory Test\", ANRIND = \"Direction of Abnormality\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADLB\", adlb, code = '\n                  ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\") %&gt;%\n                var_relabel(PARAM = \"Laboratory Test\", ANRIND = \"Direction of Abnormality\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_abnormality(\n      label = \"Abnormality Table\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, subset = c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adlb, subset = c(\"LBCAT\", \"PARAM\", \"AVISIT\")),\n        selected = c(\"LBCAT\", \"PARAM\"),\n        keep_order = TRUE\n      ),\n      grade = choices_selected(\n        choices = variable_choices(adlb, subset = \"ANRIND\"),\n        selected = \"ANRIND\",\n        fixed = TRUE\n      ),\n      abnormal = list(low = \"LOW\", high = \"HIGH\"),\n      exclude_base_abn = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:29:24.3421 pid:12485 token:[] teal.modules.clinical Initializing tm_t_abnormality\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] dplyr_1.1.3                  scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt08.html",
+    "href": "tables/lab-results/lbt08.html",
+    "title": "LBT08",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb &lt;- adlb %&gt;%\n  mutate(\n    GRADDR = case_when(\n      PARAMCD == \"ALT\" ~ \"L\",\n      PARAMCD == \"CRP\" ~ \"B\",\n      PARAMCD == \"IGA\" ~ \"H\"\n    )\n  ) %&gt;%\n  filter(SAFFL == \"Y\" & ONTRTFL == \"Y\" & GRADDR != \"\")\n\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\ndf &lt;- h_adlb_worsen(\n  adlb,\n  worst_flag_low = c(\"WGRLOFL\" = \"Y\"),\n  worst_flag_high = c(\"WGRHIFL\" = \"Y\"),\n  direction_var = \"GRADDR\"\n)\n\nattributes(df$GRADDR) &lt;- list(\"label\" = \"Direction of Abnormality\")\n\n\n\n\nNote: The direction of the shift table for each lab test is based on metadata and NCI CTCAE specifications. In addition, the worst laboratory flags must be selected appropriately to match the direction of abnormality. For example, if any lab requires a shift table for both directions, then both worst_flag_low and worst_flag_high must be specified in h_adlb_worsen. If all labs requires a shift table for only one direction, then the matching worst lab flag variable must be selected in h_adlb_worsen.\n\nCoderesult &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARMCD\") %&gt;%\n  split_rows_by(\"PARAMCD\", label_pos = \"topleft\", split_label = obj_label(df$PARAMCD)) %&gt;%\n  split_rows_by(\"GRADDR\", label_pos = \"topleft\", split_label = obj_label(df$GRADDR)) %&gt;%\n  count_abnormal_lab_worsen_by_baseline(\n    var = \"ATOXGR\",\n    variables = list(\n      id = \"USUBJID\",\n      baseline_var = \"BTOXGR\",\n      direction_var = \"GRADDR\"\n    )\n  ) %&gt;%\n  append_topleft(\"    Highest NCI CTCAE Grade\") %&gt;%\n  build_table(df = df, alt_counts_df = adsl)\n\nresult\n\nParameter Code                                                                \n  Direction of Abnormality        ARM A            ARM B            ARM C     \n    Highest NCI CTCAE Grade      (N=134)          (N=134)          (N=132)    \n——————————————————————————————————————————————————————————————————————————————\nALT                                                                           \n  Low                                                                         \n    1                         11/113 (9.7%)     9/117 (7.7%)    15/123 (12.2%)\n    2                         15/119 (12.6%)   23/123 (18.7%)   16/127 (12.6%)\n    3                         15/127 (11.8%)   22/128 (17.2%)   14/128 (10.9%)\n    4                         17/130 (13.1%)   10/131 (7.6%)    18/130 (13.8%)\n    Any                       58/130 (44.6%)   64/131 (48.9%)   63/130 (48.5%)\nCRP                                                                           \n  High                                                                        \n    1                         18/114 (15.8%)   18/112 (16.1%)   19/115 (16.5%)\n    2                         20/122 (16.4%)   13/122 (10.7%)   14/122 (11.5%)\n    3                         23/124 (18.5%)   14/128 (10.9%)   20/129 (15.5%)\n    4                         12/131 (9.2%)    20/132 (15.2%)   11/132 (8.3%) \n    Any                       73/131 (55.7%)   65/132 (49.2%)   64/132 (48.5%)\n  Low                                                                         \n    1                         20/119 (16.8%)   18/113 (15.9%)   11/112 (9.8%) \n    2                         24/122 (19.7%)   21/118 (17.8%)    17/121 (14%) \n    3                         26/127 (20.5%)   20/127 (15.7%)   22/123 (17.9%)\n    4                         10/131 (7.6%)    16/132 (12.1%)   21/130 (16.2%)\n    Any                       80/131 (61.1%)   75/132 (56.8%)   71/130 (54.6%)\nIGA                                                                           \n  High                                                                        \n    1                         18/119 (15.1%)   11/116 (9.5%)    15/113 (13.3%)\n    2                         15/124 (12.1%)   23/120 (19.2%)   19/115 (16.5%)\n    3                         21/128 (16.4%)   21/124 (16.9%)   20/120 (16.7%)\n    4                         12/132 (9.1%)    12/129 (9.3%)     9/131 (6.9%) \n    Any                        66/132 (50%)    67/129 (51.9%)   63/131 (48.1%)\n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt11_bl.html",
+    "href": "tables/lab-results/lbt11_bl.html",
+    "title": "LBT11_BL",
+    "section": "",
+    "text": "Data Setup\nTime-To-Event Summary\nTime-To-Event Summary  Selecting Sections to Display\nTime-To-Event Summary  with Stratified Analysis\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsaftte &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadsaftte &lt;- df_explicit_na(adsaftte)\n\nadsl_safl &lt;- dplyr::filter(adsl, .data$SAFFL == \"Y\")\n\nanl &lt;- adsaftte %&gt;%\n  dplyr::filter(\n    SAFFL == \"Y\",\n    PARAMCD == \"HYSTTEBL\"\n  ) %&gt;%\n  dplyr::mutate(\n    AVAL = .data$AVAL * dplyr::case_when( # convert to days, if possible\n      .data$AVALU == \"WEEKS\" ~ 7,\n      .data$AVALU == \"MONTHS\" ~ 30.4375,\n      .data$AVALU == \"YEARS\" ~ 365,\n      TRUE ~ 1\n    ),\n    AVALU = factor(dplyr::case_when(\n      .data$AVALU %in% c(\"WEEKS\", \"MONTHS\", \"YEARS\") ~ factor(\"DAYS\"),\n      TRUE ~ .data$AVALU\n    ), levels = \"DAYS\"),\n    is_event = CNSR == 0, # this will be a LLT event\n    event_grp = factor(\n      dplyr::case_when(\n        CNSR == 0 ~ \"Patients with LLT event (%)\",\n        CNSR == 1 ~ \"Patients without LLT event (%)\"\n      ),\n      levels = c(\n        \"Patients with LLT event (%)\",\n        \"Patients without LLT event (%)\"\n      )\n    )\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Unstratified Analysis\",\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B           ARM C    \n                                    (N=134)         (N=134)         (N=132)   \n——————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  \nPatients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) \nTime to 1st LLT Event (DAYS)                                                  \n  Median                              NA              NA             721.0    \n    95% CI                            NA          (681.0, NA)     (691.0, NA) \n  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  \n  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 \n  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0\nUnstratified Analysis                                                         \n  p-value (log-rank)                                0.5013          0.6413    \n  Hazard Ratio                                       1.27            0.84     \n  95% CI                                         (0.63, 2.56)    (0.40, 1.75) \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B           ARM C    \n                                    (N=134)         (N=134)         (N=132)   \n——————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  \nPatients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) \nTime to 1st LLT Event (DAYS)                                                  \n  Median                              NA              NA             721.0    \n    95% CI                            NA          (681.0, NA)     (691.0, NA) \n  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  \n  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 \n  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0\n\n\n\n\n\nCodestrata &lt;- c(\"RACE\", \"SEX\")\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARMCD\", ref_group = \"ARM A\") %&gt;%\n  count_occurrences(vars = \"event_grp\") %&gt;%\n  surv_time(\n    vars = \"AVAL\",\n    var_labels = paste0(\"Time to 1st LLT Event (\", levels(anl$AVALU), \")\"),\n    is_event = \"is_event\",\n    table_names = \"time_to_event\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = \"Unstratified Analysis\",\n    control = control_coxph(pval_method = \"log-rank\"),\n    table_names = \"coxph_unstratified\"\n  ) %&gt;%\n  coxph_pairwise(\n    vars = \"AVAL\",\n    is_event = \"is_event\",\n    var_labels = paste0(\"Stratified By: \", paste(strata, collapse = \", \")),\n    strat = strata,\n    table_names = \"coxph_stratified\"\n  )\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_safl)\nresult\n\n                                     ARM A           ARM B           ARM C    \n                                    (N=134)         (N=134)         (N=132)   \n——————————————————————————————————————————————————————————————————————————————\nPatients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  \nPatients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) \nTime to 1st LLT Event (DAYS)                                                  \n  Median                              NA              NA             721.0    \n    95% CI                            NA          (681.0, NA)     (691.0, NA) \n  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  \n  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 \n  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0\nUnstratified Analysis                                                         \n  p-value (log-rank)                                0.5013          0.6413    \n  Hazard Ratio                                       1.27            0.84     \n  95% CI                                         (0.63, 2.56)    (0.40, 1.75) \nStratified By: RACE, SEX                                                      \n  p-value (log-rank)                                0.3886          0.7970    \n  Hazard Ratio                                       1.39            0.91     \n  95% CI                                         (0.65, 2.97)    (0.43, 1.93) \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsaftte &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadsaftte &lt;- df_explicit_na(adsaftte)\n\nadsl &lt;- dplyr::filter(adsl, .data$SAFFL == \"Y\")\nadsaftte &lt;- dplyr::filter(adsaftte, .data$SAFFL == \"Y\")\n\narm_ref_comp &lt;- list(\n  ACTARMCD = list(\n    ref = \"ARM B\",\n    comp = c(\"ARM A\", \"ARM C\")\n  ),\n  ARM = list(\n    ref = \"B: Placebo\",\n    comp = c(\"A: Drug X\", \"C: Combination\")\n  )\n)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\n      \"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == \"Y\")'\n    ),\n    cdisc_dataset(\n      \"ADSAFTTE\",\n      adsaftte,\n      keys = c(\"STUDYID\", \"USUBJID\", \"PARAMCD\"),\n      code = 'ADSAFTTE &lt;- synthetic_cdisc_dataset(\"latest\", \"adaette\") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == \"Y\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_tte(\n      label = \"Time To LLT Event Table\",\n      dataname = \"ADSAFTTE\",\n      arm_var = choices_selected(\n        variable_choices(adsl, c(\"ARM\", \"ARMCD\", \"ACTARMCD\")),\n        \"ARM\"\n      ),\n      arm_ref_comp = arm_ref_comp,\n      paramcd = choices_selected(\n        value_choices(adsaftte, \"PARAMCD\", \"PARAM\"),\n        \"HYSTTEBL\"\n      ),\n      strata_var = choices_selected(\n        variable_choices(adsl, c(\"RACE\", \"SEX\")),\n        c(\"RACE\", \"SEX\")\n      ),\n      time_points = choices_selected(0, NULL),\n      event_desc_var = choices_selected(\"EVNTDESC\", \"EVNTDESC\", fixed = TRUE)\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:30:53.8540 pid:12784 token:[] teal.modules.clinical Initializing tm_t_tte\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt01.html",
+    "href": "tables/lab-results/lbt01.html",
+    "title": "LBT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\nIn order to generate the LBT01 standard tabulation, the adlb dataset may be pre-processed so as to discriminate baseline from follow-up visits.\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb) %&gt;%\n  filter(ANL01FL == \"Y\")\n\n# For illustration purpose, the example focuses on \"Alanine Aminotransferase\n# Measurement\" starting from baseline, while excluding visit at week 1 for\n# subjects who were prescribed a placebo.\nadlb_f &lt;- adlb %&gt;%\n  dplyr::filter(\n    PARAM == \"Alanine Aminotransferase Measurement\" &\n      !(ACTARM == \"B: Placebo\" & AVISIT == \"WEEK 1 DAY 8\") &\n      AVISIT != \"SCREENING\"\n  )\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nafun &lt;- function(x, .var, .spl_context, ...) {\n  n_fun &lt;- sum(!is.na(x), na.rm = TRUE)\n  if (n_fun == 0) {\n    mean_sd_fun &lt;- c(NA, NA)\n    median_fun &lt;- NA\n    min_max_fun &lt;- c(NA, NA)\n  } else {\n    mean_sd_fun &lt;- c(mean(x, na.rm = TRUE), sd(x, na.rm = TRUE))\n    median_fun &lt;- median(x, na.rm = TRUE)\n    min_max_fun &lt;- c(min(x), max(x))\n  }\n  is_chg &lt;- .var == \"CHG\"\n  is_baseline &lt;- .spl_context$value[which(.spl_context$split == \"AVISIT\")] == \"BASELINE\"\n  if (is_baseline && is_chg) n_fun &lt;- mean_sd_fun &lt;- median_fun &lt;- min_max_fun &lt;- NULL\n\n  in_rows(\n    \"n\" = n_fun,\n    \"Mean (SD)\" = mean_sd_fun,\n    \"Median\" = median_fun,\n    \"Min - Max\" = min_max_fun,\n    .formats = list(\"n\" = \"xx\", \"Mean (SD)\" = \"xx.xx (xx.xx)\", \"Median\" = \"xx.xx\", \"Min - Max\" = \"xx.xx - xx.xx\"),\n    .format_na_strs = list(\"n\" = \"NE\", \"Mean (SD)\" = \"NE (NE)\", \"Median\" = \"NE\", \"Min - Max\" = \"NE - NE\")\n  )\n}\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  split_rows_by(\"PARAM\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f$PARAM)) %&gt;%\n  split_rows_by(\"AVISIT\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adlb_f$AVISIT)) %&gt;%\n  split_cols_by_multivar(\n    vars = c(\"AVAL\", \"CHG\"),\n    varlabels = c(\"Value at Visit\", \"Change from\\nBaseline\")\n  ) %&gt;%\n  analyze_colvars(afun = afun)\n\nresult &lt;- build_table(lyt, adlb_f)\nresult\n\nParameter                                         A: Drug X                        B: Placebo                      C: Combination         \n  Analysis Visit                                         Change from                       Change from                       Change from  \n                                       Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   \n                                          (N=804)          (N=804)          (N=670)          (N=670)          (N=792)          (N=792)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nAlanine Aminotransferase Measurement                                                                                                      \n  BASELINE                                                                                                                                \n    n                                       134                               134                               132                       \n    Mean (SD)                           17.74 (9.93)                      18.71 (9.83)                      19.46 (9.08)                  \n    Median                                 17.46                             18.19                             18.97                      \n    Min - Max                           0.00 - 44.06                      1.48 - 54.40                      0.57 - 39.81                  \n  WEEK 1 DAY 8                                                                                                                            \n    n                                       134              134               0                0               132              132      \n    Mean (SD)                           16.75 (9.08)    -0.99 (13.49)       NE (NE)          NE (NE)        19.61 (9.27)     0.14 (12.85) \n    Median                                 16.02            -1.28              NE               NE             19.00             0.06     \n    Min - Max                           0.05 - 36.30    -31.31 - 27.89      NE - NE          NE - NE        0.91 - 44.75    -32.45 - 38.85\n  WEEK 2 DAY 15                                                                                                                           \n    n                                       134              134              134              134              132              132      \n    Mean (SD)                           17.82 (9.60)     0.08 (14.15)     18.82 (9.73)     0.11 (14.45)     16.55 (8.15)    -2.92 (12.64) \n    Median                                 15.92             0.28            17.96            -0.93            17.02            -1.11     \n    Min - Max                           0.40 - 44.33    -32.89 - 40.55    0.18 - 44.34    -45.93 - 29.85    0.35 - 34.69    -28.36 - 23.98\n  WEEK 3 DAY 22                                                                                                                           \n    n                                       134              134              134              134              132              132      \n    Mean (SD)                           18.37 (9.30)     0.63 (13.85)     17.65 (9.58)    -1.06 (13.58)     16.75 (9.54)    -2.71 (13.22) \n    Median                                 18.11             1.13            17.68            -0.49            15.10            -2.66     \n    Min - Max                           0.59 - 41.73    -40.09 - 31.24    0.02 - 38.61    -46.30 - 31.38    0.48 - 39.23    -30.63 - 26.51\n  WEEK 4 DAY 29                                                                                                                           \n    n                                       134              134              134              134              132              132      \n    Mean (SD)                          19.17 (10.95)     1.44 (15.39)    17.22 (10.64)    -1.48 (15.20)     17.92 (9.32)    -1.54 (12.63) \n    Median                                 17.41             0.88            15.88            -2.96            17.71            -1.53     \n    Min - Max                           0.93 - 54.24    -32.93 - 46.98    0.39 - 47.96    -41.45 - 43.08    0.25 - 41.27    -30.33 - 27.99\n  WEEK 5 DAY 36                                                                                                                           \n    n                                       134              134              134              134              132              132      \n    Mean (SD)                           19.22 (9.47)     1.48 (14.49)     18.01 (9.92)    -0.69 (14.65)     18.51 (9.43)    -0.95 (12.92) \n    Median                                 19.80             2.31            18.28             1.82            19.26            -2.48     \n    Min - Max                           0.01 - 43.42    -40.08 - 30.07    0.11 - 40.64    -47.60 - 26.04    0.02 - 37.46    -29.78 - 25.00\n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\",\n      adsl,\n      code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))'\n    ),\n    cdisc_dataset(\"ADLB\",\n      adlb,\n      code = 'ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adlb\"))'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Laboratory Test Results and Change from Baseline by Visit\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"PARAM\", \"AVISIT\")),\n        selected = c(\"AVISIT\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"AVAL\", \"CHG\")),\n        selected = c(\"AVAL\", \"CHG\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = \"ALT\"\n      ),\n      parallel_vars = TRUE\n    )\n  ),\n  filter = list(ADLB = list(AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:31:47.3601 pid:12934 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt12_bl.html",
+    "href": "tables/lab-results/lbt12_bl.html",
+    "title": "LBT12_BL",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(tern)\n\nadhy &lt;- synthetic_cdisc_dataset(\"latest\", \"adhy\")\n\nanl &lt;- adhy\nanl$APERIODC &lt;- as.factor(anl$APERIODC) # to ensure the table is built even if there is no patients after filtering\nanl$ACTARM &lt;- as.factor(anl$ACTARM) # to ensure the table is built even if there is no patients after filtering\n\nanl &lt;- anl %&gt;%\n  filter(\n    SAFFL == \"Y\",\n    PARAMCD %in% c(\"ASTPBASE\", \"ALTPBASE\", \"ALTASTPB\") & AVISIT == \"POST-BASELINE\"\n  ) %&gt;%\n  mutate(\n    ARM_AVALC = factor(\n      case_when(\n        AVALC == \"Y\" ~ as.character(ACTARM),\n        TRUE ~ \"Criteria not met\"\n      ),\n      levels = c(levels(anl$ACTARM), \"Criteria not met\")\n    ),\n    PARAM = factor(\n      case_when(\n        PARAMCD == \"ASTPBASE\" ~ \"AST&gt;3x Baseline\",\n        PARAMCD == \"ALTPBASE\" ~ \"ALT&gt;3x Baseline\",\n        PARAMCD == \"ALTASTPB\" ~ \"AST&gt;3x Baseline or ALT&gt;3x Baseline\"\n      ),\n      levels = c(\"AST&gt;3x Baseline\", \"ALT&gt;3x Baseline\", \"AST&gt;3x Baseline or ALT&gt;3x Baseline\")\n    ),\n    TITLE = factor(\"First Elevated Result Occurring During\")\n  )\n\nanl &lt;- df_explicit_na(anl)\n\n\n\n\n\nCoderesult &lt;- basic_table() %&gt;%\n  split_cols_by(\"TITLE\") %&gt;%\n  split_cols_by(\"APERIODC\") %&gt;%\n  split_rows_by(\"PARAM\") %&gt;%\n  split_rows_by(\"ACTARM\", split_fun = drop_split_levels, child_labels = \"hidden\") %&gt;%\n  count_occurrences(\"ARM_AVALC\", .stats = \"fraction\", denom = \"n\", drop = TRUE) %&gt;%\n  build_table(anl)\n\ncriteria_fun &lt;- function(tr) {\n  row_label &lt;- obj_label(tr)\n  dplyr::if_else(row_label == \"Criteria not met\", TRUE, FALSE)\n}\n\nresult &lt;- result %&gt;% trim_rows(criteria = criteria_fun)\nresult\n\n                                      First Elevated Result Occurring During  \n                                          PERIOD 1              PERIOD 2      \n——————————————————————————————————————————————————————————————————————————————\nAST&gt;3x Baseline                                                               \n  A: Drug X                            14/134 (10.4%)         8/134 (6.0%)    \n  B: Placebo                            11/134 (8.2%)         11/134 (8.2%)   \n  C: Combination                       15/132 (11.4%)        14/132 (10.6%)   \nALT&gt;3x Baseline                                                               \n  A: Drug X                             7/134 (5.2%)         20/134 (14.9%)   \n  B: Placebo                            10/134 (7.5%)         9/134 (6.7%)    \n  C: Combination                        12/132 (9.1%)         8/132 (6.1%)    \nAST&gt;3x Baseline or ALT&gt;3x Baseline                                            \n  A: Drug X                             8/134 (6.0%)         22/134 (16.4%)   \n  B: Placebo                           19/134 (14.2%)        15/134 (11.2%)   \n  C: Combination                       14/132 (10.6%)         13/132 (9.8%)   \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2\n[5] dplyr_1.1.3      scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/lab-results/lbt02.html",
+    "href": "tables/lab-results/lbt02.html",
+    "title": "LBT02",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCode# Preparation of an illustrative dataset\nlibrary(scda)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\nadlb_labels &lt;- var_labels(adlb)\n\n# For illustration purposes, the example focuses on ALT\n# Measurements starting from baseline and excluding all screening visits\nadlb &lt;- subset(adlb, AVISIT != \"SCREENING\" & PARAMCD == \"ALT\")\nadlb$AVISIT &lt;- droplevels(adlb$AVISIT)\n\nvar_labels(adlb) &lt;- adlb_labels\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nl &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(var = \"ARM\") %&gt;%\n  add_overall_col(\"All Patients\") %&gt;%\n  split_rows_by(\n    var = \"AVISIT\",\n    split_fun = split_fun,\n    label_pos = \"topleft\",\n    split_label = obj_label(adlb$AVISIT)\n  ) %&gt;%\n  analyze_vars(vars = \"AVAL\")\n\nresult &lt;- build_table(l,\n  df = adlb,\n  alt_counts_df = adsl\n)\nresult\n\nAnalysis Visit    A: Drug X    B: Placebo    C: Combination   All Patients\n                   (N=134)       (N=134)        (N=132)         (N=400)   \n——————————————————————————————————————————————————————————————————————————\nBASELINE                                                                  \n  n                  134           134            132             400     \n  Mean (SD)      17.7 (9.9)    18.7 (9.8)      19.5 (9.1)      18.6 (9.6) \n  Median            17.5          18.2            19.0            18.0    \n  Min - Max      0.0 - 44.1    1.5 - 54.4      0.6 - 39.8      0.0 - 54.4 \nWEEK 1 DAY 8                                                              \n  n                  134           134            132             400     \n  Mean (SD)      16.8 (9.1)    18.9 (9.2)      19.6 (9.3)      18.4 (9.2) \n  Median            16.0          18.2            19.0            18.0    \n  Min - Max      0.1 - 36.3    0.7 - 39.9      0.9 - 44.7      0.1 - 44.7 \nWEEK 2 DAY 15                                                             \n  n                  134           134            132             400     \n  Mean (SD)      17.8 (9.6)    18.8 (9.7)      16.5 (8.2)      17.7 (9.2) \n  Median            15.9          18.0            17.0            17.0    \n  Min - Max      0.4 - 44.3    0.2 - 44.3      0.3 - 34.7      0.2 - 44.3 \nWEEK 3 DAY 22                                                             \n  n                  134           134            132             400     \n  Mean (SD)      18.4 (9.3)    17.6 (9.6)      16.8 (9.5)      17.6 (9.5) \n  Median            18.1          17.7            15.1            17.2    \n  Min - Max      0.6 - 41.7    0.0 - 38.6      0.5 - 39.2      0.0 - 41.7 \nWEEK 4 DAY 29                                                             \n  n                  134           134            132             400     \n  Mean (SD)      19.2 (11.0)   17.2 (10.6)     17.9 (9.3)     18.1 (10.3) \n  Median            17.4          15.9            17.7            17.3    \n  Min - Max      0.9 - 54.2    0.4 - 48.0      0.2 - 41.3      0.2 - 54.2 \nWEEK 5 DAY 36                                                             \n  n                  134           134            132             400     \n  Mean (SD)      19.2 (9.5)    18.0 (9.9)      18.5 (9.4)      18.6 (9.6) \n  Median            19.8          18.3            19.3            19.0    \n  Min - Max      0.0 - 43.4    0.1 - 40.6      0.0 - 37.5      0.0 - 43.4 \n\n\n\n\n\nCodelibrary(scda)\nlibrary(teal.modules.clinical)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadlb &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n\n# Ensure missing and NA values are cleaned up and convert variables to factors.\nadsl &lt;- df_explicit_na(adsl)\nadlb &lt;- df_explicit_na(adlb)\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n                                        ADSL &lt;- df_explicit_na(ADSL)'),\n    cdisc_dataset(\"ADLB\", adlb, code = 'ADLB &lt;- synthetic_cdisc_dataset(\"latest\", \"adlb\")\n                                        ADLB &lt;- df_explicit_na(ADLB)'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Laboratory Test Results by Visit\",\n      dataname = \"ADLB\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"PARAM\", \"AVISIT\")), # note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`\n        selected = c(\"PARAM\", \"AVISIT\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adlb, c(\"AVAL\")),\n        selected = c(\"AVAL\")\n      ),\n      useNA = \"ifany\",\n      paramcd = choices_selected(\n        choices = value_choices(adlb, \"PARAMCD\", \"PARAM\"),\n        selected = \"ALT\"\n      )\n    )\n  ),\n  filter = list(ADLB = list(AVAL = list()))\n)\n\n[INFO] 2023-09-25 11:32:58.5717 pid:13187 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] dplyr_1.1.3                  teal.modules.clinical_0.8.16\n [3] teal_0.14.0                  teal.transform_0.4.0        \n [5] teal.slice_0.4.0             teal.data_0.3.0             \n [7] shiny_1.7.5                  tern_0.9.0                  \n [9] rtables_0.6.3                magrittr_2.0.3              \n[11] formatters_0.5.2             scda_0.1.6                  \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disposition/dst01.html",
+    "href": "tables/disposition/dst01.html",
+    "title": "DST01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nTable with Grouping of Reasons\nTable Adding Optional Rows\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nset.seed(1, kind = \"Mersenne-Twister\")\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# reorder EOSSTT factor levels so DISCONTINUED is the last level\nadsl &lt;- df_explicit_na(adsl) %&gt;%\n  mutate(EOSSTT = factor(EOSSTT, levels = c(\"COMPLETED\", \"ONGOING\", \"DISCONTINUED\")))\n\nadsl_gp_added &lt;- adsl %&gt;%\n  mutate(DCSREASGP = case_when(\n    DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\") ~ \"Safety\",\n    (DCSREAS != \"&lt;Missing&gt;\" & !DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\")) ~ \"Non-Safety\",\n    DCSREAS == \"&lt;Missing&gt;\" ~ \"&lt;Missing&gt;\"\n  ) %&gt;% factor(levels = c(\"Safety\", \"Non-Safety\", \"&lt;Missing&gt;\")))\n\nadsl_eotstt_added &lt;- adsl_gp_added %&gt;%\n  mutate(\n    EOTSTT = sample(\n      c(\"ONGOING\", \"COMPLETED\", \"DISCONTINUED\"),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% factor(levels = c(\"COMPLETED\", \"ONGOING\", \"DISCONTINUED\"))\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_occurrences(\n    \"EOSSTT\",\n    .stats = \"count_fraction\",\n    show_labels = \"hidden\"\n  ) %&gt;%\n  analyze_vars(\n    \"DCSREAS\",\n    .stats = \"count_fraction\",\n    denom = \"N_col\",\n    show_labels = \"hidden\",\n    .indent_mods = c(count_fraction = 1L)\n  )\n\nresult1 &lt;- build_table(lyt = lyt, df = adsl)\nresult1\n\n                                  A: Drug X    B: Placebo   C: Combination   All Patients\n                                   (N=134)      (N=134)        (N=132)         (N=400)   \n—————————————————————————————————————————————————————————————————————————————————————————\nCOMPLETED                         68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) \nONGOING                           24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) \nDISCONTINUED                      42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) \n  ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  \n  DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \n  LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  \n  PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  \n  PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   \n  WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  \n  WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_occurrences(\n    \"EOSSTT\",\n    .stats = \"count_fraction\",\n    show_labels = \"hidden\"\n  ) %&gt;%\n  split_rows_by(\"DCSREASGP\", indent_mod = 1L) %&gt;%\n  analyze_vars(\n    \"DCSREAS\",\n    .stats = \"count_fraction\",\n    denom = \"N_col\",\n    show_labels = \"hidden\"\n  )\n\ntbl &lt;- build_table(lyt = lyt, df = adsl_gp_added)\nresult2 &lt;- prune_table(tbl) # remove rows containing all zeros\n\nresult2\n\n                                    A: Drug X    B: Placebo   C: Combination   All Patients\n                                     (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————————————\nCOMPLETED                           68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) \nONGOING                             24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) \nDISCONTINUED                        42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) \n  Safety                                                                                   \n    ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  \n    DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \n  Non-Safety                                                                               \n    LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  \n    PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  \n    PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   \n    WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  \n    WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\n    \"ACTARM\",\n    split_fun = add_overall_level(\"All Patients\", first = FALSE)\n  ) %&gt;%\n  count_occurrences(\n    \"EOTSTT\",\n    .stats = \"count_fraction\",\n    show_labels = \"hidden\"\n  )\n\ntbl &lt;- build_table(lyt = lyt, df = adsl_eotstt_added)\ntbl &lt;- prune_table(tbl) # remove rows containing all zeros\n\n# Combine tables\ncol_info(result2) &lt;- col_info(tbl)\nresult3 &lt;- rbind(result2, tbl)\n\nresult3\n\n                                    A: Drug X    B: Placebo   C: Combination   All Patients\n                                     (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————————————\nCOMPLETED                           68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) \nONGOING                             24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) \nDISCONTINUED                        42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) \n  Safety                                                                                   \n    ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  \n    DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) \n  Non-Safety                                                                               \n    LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  \n    PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  \n    PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   \n    WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  \n    WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  \nCOMPLETED                           46 (34.3%)   38 (28.4%)     41 (31.1%)     125 (31.2%) \nONGOING                             50 (37.3%)   51 (38.1%)     46 (34.8%)     147 (36.8%) \nDISCONTINUED                        38 (28.4%)   45 (33.6%)     45 (34.1%)     128 (32.0%) \n\n\n\n\n\nCodelibrary(teal.modules.clinical)\nlibrary(scda)\nlibrary(dplyr)\n\nset.seed(1, kind = \"Mersenne-Twister\")\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadsl &lt;- df_explicit_na(adsl)\nadsl &lt;- adsl %&gt;%\n  mutate(\n    DCSREASGP = case_when(\n      DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\") ~ \"Safety\",\n      (DCSREAS != \"&lt;Missing&gt;\" & !DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\")) ~ \"Non-Safety\",\n      DCSREAS == \"&lt;Missing&gt;\" ~ \"&lt;Missing&gt;\"\n    ) %&gt;% as.factor(),\n    EOTSTT = sample(\n      c(\"ONGOING\", \"COMPLETED\", \"DISCONTINUED\"),\n      size = nrow(adsl),\n      replace = TRUE\n    ) %&gt;% as.factor()\n  ) %&gt;%\n  var_relabel(\n    EOTSTT = \"End Of Treatment Status\"\n  )\n\ndate_vars_asl &lt;- names(adsl)[vapply(adsl, function(x) inherits(x, c(\"Date\", \"POSIXct\", \"POSIXlt\")), logical(1))]\ndemog_vars_asl &lt;- names(adsl)[!(names(adsl) %in% c(\"USUBJID\", \"STUDYID\", date_vars_asl))]\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl),\n    code = '\n     set.seed(1, kind = \"Mersenne-Twister\")\n     ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n     ADSL &lt;- df_explicit_na(ADSL)\n     ADSL &lt;- ADSL %&gt;%\n        mutate(\n            DCSREASGP = case_when(\n                DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\") ~ \"Safety\",\n                (DCSREAS != \"&lt;Missing&gt;\" & !DCSREAS %in% c(\"ADVERSE EVENT\", \"DEATH\")) ~ \"Non-Safety\",\n                DCSREAS == \"&lt;Missing&gt;\" ~ \"&lt;Missing&gt;\"\n    )  %&gt;% as.factor(),\n    EOTSTT = sample(\n      c(\"ONGOING\", \"COMPLETED\", \"DISCONTINUED\"),\n      size = nrow(ADSL),\n      replace = TRUE\n    ) %&gt;% as.factor()\n  ) %&gt;% var_relabel(\n    EOTSTT = \"End Of Treatment Status\"\n  )\n     ',\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary(\n      label = \"Disposition Table\",\n      dataname = \"ADSL\",\n      arm_var = choices_selected(c(\"ARM\", \"ARMCD\"), \"ARM\"),\n      summarize_vars = choices_selected(\n        variable_choices(adsl, demog_vars_asl),\n        c(\"EOSSTT\", \"DCSREAS\", \"EOTSTT\")\n      ),\n      useNA = \"ifany\"\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:34:07.0285 pid:13383 token:[] teal.modules.clinical Initializing tm_t_summary\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/disposition/pdt02.html",
+    "href": "tables/disposition/pdt02.html",
+    "title": "PDT02",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(scda)\nlibrary(tern)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\naddv &lt;- synthetic_cdisc_dataset(\"latest\", \"addv\")\n\nadsl &lt;- df_explicit_na(adsl)\naddv &lt;- df_explicit_na(addv)\n\naddv_pan &lt;- addv %&gt;%\n  filter(AEPRELFL == \"Y\" & DVCAT == \"MAJOR\") %&gt;%\n  var_relabel(\n    DVREAS = \"Primary Reason\",\n    DVTERM = \"Description\"\n  )\n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ACTARM\") %&gt;%\n  analyze_num_patients(\n    vars = \"USUBJID\",\n    .stats = c(\"unique\", \"nonunique\"),\n    .labels = c(\n      unique = \"Total number of patients with at least one major protocol deviation related to epidemic/pandemic\",\n      nonunique = \"Total number of major protocol deviations related to epidemic/pandemic\"\n    )\n  ) %&gt;%\n  split_rows_by(\n    \"DVREAS\",\n    split_fun = drop_split_levels,\n    nested = FALSE,\n    label_pos = \"topleft\",\n    split_label = obj_label(addv_pan$DVREAS)\n  ) %&gt;%\n  summarize_num_patients(\n    var = \"USUBJID\",\n    .stats = c(\"unique\"),\n    .labels = \"Site action due to epidemic/pandemic\"\n  ) %&gt;%\n  count_occurrences(vars = \"DVTERM\") %&gt;%\n  append_varlabels(addv_pan, \"DVTERM\", indent = 1L)\n\nresult &lt;- build_table(lyt, addv_pan, alt_counts_df = adsl)\nresult\n\nPrimary Reason                                                                                     A: Drug X   B: Placebo   C: Combination\n  Description                                                                                       (N=134)     (N=134)        (N=132)    \n——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————\nTotal number of patients with at least one major protocol deviation related to epidemic/pandemic   8 (6.0%)     4 (3.0%)       4 (3.0%)   \nTotal number of major protocol deviations related to epidemic/pandemic                                 8           5              4       \nSite action due to epidemic/pandemic                                                               8 (6.0%)     4 (3.0%)       4 (3.0%)   \n  Dose missed or significantly out of window                                                       2 (1.5%)        0           1 (0.8%)   \n  Failure to sign updated ICF within two visits                                                    2 (1.5%)     1 (0.7%)       1 (0.8%)   \n  Missed 2 or more efficacy assessments                                                            1 (0.7%)     2 (1.5%)          0       \n  Significant deviation from planned dose                                                          3 (2.2%)     1 (0.7%)       2 (1.5%)   \n\n\n\n\n\nCode# In progress\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  \n[5] formatters_0.5.2 scda_0.1.6      \n\nloaded via a namespace (and not attached):\n [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   \n [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    \n [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   \n[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       \n[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  \n[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     \n[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      \n[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    \n[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      \n[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   \n[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   \n[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/risk-management-plan/rmpt05.html",
+    "href": "tables/risk-management-plan/rmpt05.html",
+    "title": "RMPT05",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadex &lt;- df_explicit_na(adex)\n\n# Simulate ADEX records with PARAMCD == \"TDURD\" as they are not in the sample dataset.\nset.seed(1)\nadex2 &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE)\n  ) %&gt;%\n  bind_rows(adex)\n\n# Now pre-processing steps are carried out.\nanl &lt;- adex2 %&gt;%\n  filter(\n    PARAMCD == \"TDURD\",\n    PARCAT2 == \"Drug A\",\n    SAFFL == \"Y\"\n  ) %&gt;%\n  mutate()\n\nadsl_f &lt;- adsl %&gt;% filter(adsl$SAFFL == \"Y\")\n\n\n\n\n\nCodelyt &lt;- basic_table(\n  title = \"Extent of Exposure by Race: Safety-Evaluable Patients\",\n  main_footer = \"* Person time is the sum of exposure across all patients in unit: days.\",\n  show_colcounts = TRUE\n) %&gt;%\n  summarize_patients_exposure_in_cols(\n    var = \"AVAL\", col_split = TRUE,\n    .labels = c(n_patients = \"Patients\", sum_exposure = \"Person time*\")\n  ) %&gt;%\n  analyze_patients_exposure_in_cols(\n    var = \"RACE\",\n    col_split = FALSE\n  ) %&gt;%\n  append_topleft(c(\"\", obj_label(adex$RACE)))\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_f)\nresult\n\nExtent of Exposure by Race: Safety-Evaluable Patients\n\n————————————————————————————————————————————————————————————————————————\n                                               Patients     Person time*\nRace                                            (N=400)       (N=400)   \n————————————————————————————————————————————————————————————————————————\nTotal patients numbers/person time            217 (54.2%)      20641    \n  ASIAN                                       113 (28.2%)      10239    \n  BLACK OR AFRICAN AMERICAN                   48 (12.0%)        4481    \n  WHITE                                       40 (10.0%)        4237    \n  AMERICAN INDIAN OR ALASKA NATIVE             14 (3.5%)        1566    \n  MULTIPLE                                     1 (0.2%)          58     \n  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER    1 (0.2%)          60     \n  OTHER                                        0 (0.0%)          0      \n  UNKNOWN                                      0 (0.0%)          0      \n————————————————————————————————————————————————————————————————————————\n\n* Person time is the sum of exposure across all patients in unit: days.\n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\nlabels &lt;- var_labels(adex)\n\nset.seed(1, kind = \"Mersenne-Twister\")\nadex &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n    AVALU = \"Days\"\n  ) %&gt;%\n  bind_rows(adex)\n\nvar_labels(adex) &lt;- labels\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADEX\", adex,\n      code = 'ADEX &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n  labels &lt;- var_labels(ADEX)\n  set.seed(1, kind = \"Mersenne-Twister\")\n  ADEX &lt;- ADEX %&gt;%\n    distinct(USUBJID, .keep_all = TRUE) %&gt;%\n    mutate(PARAMCD = \"TDURD\",\n           PARAM = \"Overall duration (days)\",\n           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n           AVALU = \"Days\") %&gt;%\n    bind_rows(ADEX)\n  var_labels(ADEX) &lt;- labels'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_exposure(\n      label = \"Duration of Exposure Table\",\n      dataname = \"ADEX\",\n      paramcd = choices_selected(\n        choices = value_choices(adex, \"PARAMCD\", \"PARAM\"),\n        selected = \"TDURD\"\n      ),\n      col_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"SEX\", \"ARM\")),\n        selected = NULL\n      ),\n      row_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"RACE\", \"STRATA1\", \"SEX\")),\n        selected = \"RACE\"\n      ),\n      parcat = choices_selected(\n        choices = value_choices(adex, \"PARCAT2\"),\n        selected = \"Drug A\"\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:35:35.9803 pid:13682 token:[] teal.modules.clinical Initializing tm_t_exposure\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/risk-management-plan/rmpt01.html",
+    "href": "tables/risk-management-plan/rmpt01.html",
+    "title": "RMPT01",
+    "section": "",
+    "text": "Data Setup\nStandard Table\nteal App\nReproducibility\n\n\n\n\nCodelibrary(tern)\nlibrary(scda)\nlibrary(dplyr)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\nadex &lt;- df_explicit_na(adex)\n\n# Simulate ADEX records with PARAMCD == \"TDURD\" as they are not in sample scda dataset.\nset.seed(1, kind = \"Mersenne-Twister\")\nadex2 &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE)\n  ) %&gt;%\n  bind_rows(adex)\n\n# Now pre-processing steps are carried out.\nanl &lt;- adex2 %&gt;%\n  filter(\n    PARAMCD == \"TDURD\",\n    PARCAT2 == \"Drug A\",\n    SAFFL == \"Y\"\n  ) %&gt;%\n  mutate(\n    aval_months = day2month(AVAL),\n    aval_months_cat = factor(case_when(\n      aval_months &lt; 1 ~ \"&lt; 1 month\",\n      aval_months &gt;= 1 & aval_months &lt; 3 ~ \"1 to &lt;3 months\",\n      aval_months &gt;= 3 & aval_months &lt; 6 ~ \"3 to &lt;6 months\",\n      TRUE ~ \"&gt;=6 months\"\n    ), levels = c(\"&lt; 1 month\", \"1 to &lt;3 months\", \"3 to &lt;6 months\", \"&gt;=6 months\"))\n  )\n\nadsl_f &lt;- adsl %&gt;% filter(adsl$SAFFL == \"Y\")\n\n\n\n\n\nCodelyt &lt;- basic_table(\n  title = \"Duration of Exposure: Safety-Evaluable Patients\",\n  main_footer = \"* Patient Time is the sum of exposure across all patients in days.\",\n  show_colcounts = TRUE\n) %&gt;%\n  summarize_patients_exposure_in_cols(\n    var = \"AVAL\", col_split = TRUE,\n    .labels = c(n_patients = \"Number of Patients\", sum_exposure = \"Patient Time*\"),\n    custom_label = \"Total Number of Patients and Patient Time\"\n  ) %&gt;%\n  analyze_patients_exposure_in_cols(\n    var = \"aval_months_cat\",\n    col_split = FALSE\n  ) %&gt;%\n  append_topleft(c(\"\", \"Duration of exposure\"))\n\nresult &lt;- build_table(lyt, df = anl, alt_counts_df = adsl_f)\nresult\n\nDuration of Exposure: Safety-Evaluable Patients\n\n——————————————————————————————————————————————————————————————————————————————\n                                            Number of Patients   Patient Time*\nDuration of exposure                             (N=400)            (N=400)   \n——————————————————————————————————————————————————————————————————————————————\nTotal Number of Patients and Patient Time      217 (54.2%)           20641    \n  &lt; 1 month                                     28 (7.0%)             504     \n  1 to &lt;3 months                                79 (19.8%)           4727     \n  3 to &lt;6 months                               101 (25.2%)           13690    \n  &gt;=6 months                                     9 (2.2%)            1720     \n——————————————————————————————————————————————————————————————————————————————\n\n* Patient Time is the sum of exposure across all patients in days.\n\n\n\n\n\nCodelibrary(scda)\nlibrary(dplyr)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\nadex &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n\nlabels &lt;- var_labels(adex)\nset.seed(1, kind = \"Mersenne-Twister\")\nadex &lt;- adex %&gt;%\n  distinct(USUBJID, .keep_all = TRUE) %&gt;%\n  mutate(\n    PARAMCD = \"TDURD\",\n    PARAM = \"Overall duration (days)\",\n    AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),\n    AVALU = \"Days\"\n  ) %&gt;%\n  bind_rows(adex)\n\nadex &lt;- adex %&gt;%\n  mutate(\n    aval_months = day2month(AVAL),\n    aval_months_cat = factor(case_when(\n      aval_months &lt; 1 ~ \"&lt; 1 month\",\n      aval_months &gt;= 1 & aval_months &lt; 3 ~ \"1 to &lt;3 months\",\n      aval_months &gt;= 3 & aval_months &lt; 6 ~ \"3 to &lt;6 months\",\n      TRUE ~ \"&gt;=6 months\"\n    ), levels = c(\"&lt; 1 month\", \"1 to &lt;3 months\", \"3 to &lt;6 months\", \"&gt;=6 months\"))\n  ) %&gt;%\n  select(-aval_months)\n\nvar_labels(adex) &lt;- c(labels, \"Overall duration\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl, code = 'ADSL &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")'),\n    cdisc_dataset(\"ADEX\", adex, code = 'ADEX &lt;- synthetic_cdisc_dataset(\"latest\", \"adex\")\n    labels &lt;- var_labels(ADEX)\n    set.seed(1, kind = \"Mersenne-Twister\")\n    ADEX &lt;- ADEX %&gt;%\n      distinct(USUBJID, .keep_all = TRUE) %&gt;%\n      mutate(PARAMCD = \"TDURD\",\n             PARAM = \"Overall duration (days)\",\n             AVAL = sample(\n             x = seq(1, 200), size = n(), replace = TRUE\n             ),\n             AVALU = \"Days\") %&gt;%\n      bind_rows(ADEX)\n\n    ADEX &lt;-ADEX %&gt;%\n      mutate(\n        aval_months = day2month(AVAL),\n        aval_months_cat = factor(case_when(\n          aval_months &lt; 1 ~ \"&lt; 1 month\",\n          aval_months &gt;= 1 & aval_months &lt; 3 ~ \"1 to &lt;3 months\",\n          aval_months &gt;= 3 & aval_months &lt; 6 ~ \"3 to &lt;6 months\",\n          TRUE ~ \"&gt;=6 months\"\n        ), levels = c(\"&lt; 1 month\", \"1 to &lt;3 months\", \"3 to &lt;6 months\", \"&gt;=6 months\"))) %&gt;%\n      select(-aval_months)\n\n    var_labels(ADEX) &lt;- c(labels, \"Overall duration\")'),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_exposure(\n      label = \"Duration of Exposure Table\",\n      dataname = \"ADEX\",\n      paramcd = choices_selected(\n        choices = value_choices(adex, \"PARAMCD\", \"PARAM\"),\n        selected = \"TDURD\"\n      ),\n      col_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"SEX\", \"ARM\")),\n        selected = NULL\n      ),\n      row_by_var = choices_selected(\n        choices = variable_choices(adex, subset = c(\"aval_months_cat\", \"RACE\", \"STRATA1\", \"SEX\")),\n        selected = \"aval_months_cat\"\n      ),\n      parcat = choices_selected(\n        choices = value_choices(adex, \"PARCAT2\"),\n        selected = \"Drug A\"\n      ),\n      add_total = FALSE\n    )\n  ),\n  filter = list(\n    ADSL = list(SAFFL = \"Y\")\n  )\n)\n\n[INFO] 2023-09-25 11:36:31.2958 pid:13878 token:[] teal.modules.clinical Initializing tm_t_exposure\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] dplyr_1.1.3                  scda_0.1.6                  \n [9] tern_0.9.0                   rtables_0.6.3               \n[11] magrittr_2.0.3               formatters_0.5.2            \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           \n[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          \n[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           \n[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         \n[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        \n[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            \n[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       \n[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        \n[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        \n[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       \n[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      \n[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          \n[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     \n[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0\n[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         \n[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           \n[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        \n[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      \n[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  \n[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          \n[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      \n[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        \n[85] pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  },
+  {
+    "objectID": "tables/safety/enrollment01.html",
+    "href": "tables/safety/enrollment01.html",
+    "title": "ENTXX",
+    "section": "",
+    "text": "Data Setup\nENT01 – Enrollment by Region,  Country, and Investigator Number\nENT01A – Enrollment by Country  and Investigator Number\nENT02 – Enrollment by Region, Country,  and Investigator Number/Name\nENT02A – Enrollment by Country  and Investigator Number/Name\nteal App\nReproducibility\n\n\n\n\nCodelibrary(dplyr)\nlibrary(forcats)\nlibrary(scda)\nlibrary(tern)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\nadsl &lt;- adsl %&gt;%\n  mutate(\n    REGION1 = droplevels(REGION1),\n    COUNTRY = droplevels(COUNTRY),\n    INVID_INVNAM = paste(INVID, INVNAM, sep = \" / \")\n  ) %&gt;%\n  mutate(\n    INVID = factor(INVID),\n    SITEID = factor(SITEID),\n    INVNAM = factor(INVNAM),\n    INVID_INVNAM = factor(INVID_INVNAM)\n  ) %&gt;%\n  var_relabel(\n    INVID_INVNAM = \"Investigator Number/Name\",\n    REGION1 = \"Geographic Region 1\",\n    COUNTRY = \"Country\",\n    INVID = \"Investigator Identifier\"\n  ) %&gt;%\n  arrange(REGION1, COUNTRY, INVID)\n\n\n\n\n\nCode# Define the split function\nsplit_fun &lt;- drop_split_levels\n\nlyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  split_rows_by(\"REGION1\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$REGION1)) %&gt;%\n  summarize_row_groups() %&gt;%\n  split_rows_by(\"COUNTRY\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$COUNTRY)) %&gt;%\n  summarize_row_groups() %&gt;%\n  analyze(\"INVID\") %&gt;%\n  append_varlabels(adsl, \"INVID\", 2L)\n\nresult &lt;- build_table(lyt, adsl) %&gt;%\n  prune_table()\n\nresult\n\nGeographic Region 1                                                                  \n  Country                     A: Drug X    B: Placebo   C: Combination   All Patients\n    Investigator Identifier    (N=134)      (N=134)        (N=132)         (N=400)   \n—————————————————————————————————————————————————————————————————————————————————————\nAfrica                         8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n  NGA                          8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n    INV ID NGA-1                  3            3              4               10     \n    INV ID NGA-11                 1            2              3               6      \n    INV ID NGA-12                 0            1              1               2      \n    INV ID NGA-17                 2            0              0               2      \n    INV ID NGA-2                  1            1              0               2      \n    INV ID NGA-4                  1            0              1               2      \n    INV ID NGA-5                  0            0              1               1      \n    INV ID NGA-6                  0            0              1               1      \nAsia                          91 (67.9%)   94 (70.1%)     83 (62.9%)     268 (67.0%) \n  CHN                         74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) \n    INV ID CHN-1                  21           20             16              57     \n    INV ID CHN-10                 0            1              0               1      \n    INV ID CHN-11                 12           20             16              48     \n    INV ID CHN-12                 4            3              1               8      \n    INV ID CHN-13                 2            6              0               8      \n    INV ID CHN-14                 4            2              3               9      \n    INV ID CHN-15                 2            0              4               6      \n    INV ID CHN-16                 0            3              3               6      \n    INV ID CHN-17                 4            4              3               11     \n    INV ID CHN-18                 1            0              2               3      \n    INV ID CHN-2                  9            4              3               16     \n    INV ID CHN-3                  5            1              5               11     \n    INV ID CHN-4                  3            3              3               9      \n    INV ID CHN-5                  4            3              4               11     \n    INV ID CHN-6                  1            3              0               4      \n    INV ID CHN-7                  0            5              1               6      \n    INV ID CHN-8                  1            1              0               2      \n    INV ID CHN-9                  1            2              0               3      \n  PAK                         12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  \n    INV ID PAK-1                  2            4              4               10     \n    INV ID PAK-11                 4            3              2               9      \n    INV ID PAK-12                 2            0              0               2      \n    INV ID PAK-13                 1            1              0               2      \n    INV ID PAK-14                 1            0              0               1      \n    INV ID PAK-15                 1            0              0               1      \n    INV ID PAK-2                  1            0              2               3      \n    INV ID PAK-4                  0            1              1               2      \n    INV ID PAK-5                  0            0              1               1      \n  JPN                          5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  \n    INV ID JPN-1                  2            2              1               5      \n    INV ID JPN-11                 0            0              3               3      \n    INV ID JPN-12                 0            0              1               1      \n    INV ID JPN-14                 0            1              0               1      \n    INV ID JPN-17                 0            0              2               2      \n    INV ID JPN-18                 1            0              0               1      \n    INV ID JPN-2                  0            0              1               1      \n    INV ID JPN-3                  0            1              0               1      \n    INV ID JPN-5                  1            0              1               2      \n    INV ID JPN-6                  1            0              0               1      \nEurasia                        5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n  RUS                          5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n    INV ID RUS-1                  1            0              0               1      \n    INV ID RUS-11                 0            2              2               4      \n    INV ID RUS-12                 0            1              0               1      \n    INV ID RUS-13                 1            0              0               1      \n    INV ID RUS-14                 0            0              1               1      \n    INV ID RUS-16                 1            1              0               2      \n    INV ID RUS-18                 1            0              0               1      \n    INV ID RUS-2                  0            1              0               1      \n    INV ID RUS-3                  0            0              1               1      \n    INV ID RUS-4                  0            2              1               3      \n    INV ID RUS-5                  0            1              0               1      \n    INV ID RUS-6                  1            0              0               1      \n    INV ID RUS-7                  0            0              1               1      \nEurope                         4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n  GBR                          4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n    INV ID GBR-1                  2            0              1               3      \n    INV ID GBR-11                 0            1              1               2      \n    INV ID GBR-13                 1            0              0               1      \n    INV ID GBR-15                 1            0              0               1      \n    INV ID GBR-17                 0            1              0               1      \n    INV ID GBR-6                  0            1              0               1      \nNorth America                 13 (9.7%)    15 (11.2%)     20 (15.2%)      48 (12.0%) \n  USA                         10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) \n    INV ID USA-1                  1            4              5               10     \n    INV ID USA-11                 4            2              3               9      \n    INV ID USA-12                 1            2              3               6      \n    INV ID USA-14                 1            0              0               1      \n    INV ID USA-15                 0            1              1               2      \n    INV ID USA-17                 1            1              0               2      \n    INV ID USA-19                 0            0              1               1      \n    INV ID USA-2                  0            0              1               1      \n    INV ID USA-3                  1            0              1               2      \n    INV ID USA-4                  0            1              1               2      \n    INV ID USA-5                  0            1              0               1      \n    INV ID USA-6                  0            1              0               1      \n    INV ID USA-8                  0            0              1               1      \n    INV ID USA-9                  1            0              0               1      \n  CAN                          3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  \n    INV ID CAN-1                  1            1              0               2      \n    INV ID CAN-11                 1            0              1               2      \n    INV ID CAN-14                 1            0              0               1      \n    INV ID CAN-4                  0            1              1               2      \n    INV ID CAN-5                  0            0              1               1      \nSouth America                 13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n  BRA                         13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n    INV ID BRA-1                  4            2              2               8      \n    INV ID BRA-11                 4            0              4               8      \n    INV ID BRA-12                 0            1              0               1      \n    INV ID BRA-13                 1            0              0               1      \n    INV ID BRA-14                 1            0              1               2      \n    INV ID BRA-15                 1            0              0               1      \n    INV ID BRA-2                  1            1              0               2      \n    INV ID BRA-3                  0            2              0               2      \n    INV ID BRA-4                  0            1              1               2      \n    INV ID BRA-5                  0            0              1               1      \n    INV ID BRA-6                  1            0              0               1      \n    INV ID BRA-7                  0            0              1               1      \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  split_rows_by(\"COUNTRY\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$COUNTRY)) %&gt;%\n  summarize_row_groups() %&gt;%\n  analyze(\"INVID\") %&gt;%\n  append_varlabels(adsl, \"INVID\", 1L)\n\nresult &lt;- build_table(lyt, adsl) %&gt;%\n  prune_table()\n\nresult\n\nCountry                     A: Drug X    B: Placebo   C: Combination   All Patients\n  Investigator Identifier    (N=134)      (N=134)        (N=132)         (N=400)   \n———————————————————————————————————————————————————————————————————————————————————\nCHN                         74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) \n  INV ID CHN-1                  21           20             16              57     \n  INV ID CHN-10                 0            1              0               1      \n  INV ID CHN-11                 12           20             16              48     \n  INV ID CHN-12                 4            3              1               8      \n  INV ID CHN-13                 2            6              0               8      \n  INV ID CHN-14                 4            2              3               9      \n  INV ID CHN-15                 2            0              4               6      \n  INV ID CHN-16                 0            3              3               6      \n  INV ID CHN-17                 4            4              3               11     \n  INV ID CHN-18                 1            0              2               3      \n  INV ID CHN-2                  9            4              3               16     \n  INV ID CHN-3                  5            1              5               11     \n  INV ID CHN-4                  3            3              3               9      \n  INV ID CHN-5                  4            3              4               11     \n  INV ID CHN-6                  1            3              0               4      \n  INV ID CHN-7                  0            5              1               6      \n  INV ID CHN-8                  1            1              0               2      \n  INV ID CHN-9                  1            2              0               3      \nUSA                         10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) \n  INV ID USA-1                  1            4              5               10     \n  INV ID USA-11                 4            2              3               9      \n  INV ID USA-12                 1            2              3               6      \n  INV ID USA-14                 1            0              0               1      \n  INV ID USA-15                 0            1              1               2      \n  INV ID USA-17                 1            1              0               2      \n  INV ID USA-19                 0            0              1               1      \n  INV ID USA-2                  0            0              1               1      \n  INV ID USA-3                  1            0              1               2      \n  INV ID USA-4                  0            1              1               2      \n  INV ID USA-5                  0            1              0               1      \n  INV ID USA-6                  0            1              0               1      \n  INV ID USA-8                  0            0              1               1      \n  INV ID USA-9                  1            0              0               1      \nBRA                         13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n  INV ID BRA-1                  4            2              2               8      \n  INV ID BRA-11                 4            0              4               8      \n  INV ID BRA-12                 0            1              0               1      \n  INV ID BRA-13                 1            0              0               1      \n  INV ID BRA-14                 1            0              1               2      \n  INV ID BRA-15                 1            0              0               1      \n  INV ID BRA-2                  1            1              0               2      \n  INV ID BRA-3                  0            2              0               2      \n  INV ID BRA-4                  0            1              1               2      \n  INV ID BRA-5                  0            0              1               1      \n  INV ID BRA-6                  1            0              0               1      \n  INV ID BRA-7                  0            0              1               1      \nPAK                         12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  \n  INV ID PAK-1                  2            4              4               10     \n  INV ID PAK-11                 4            3              2               9      \n  INV ID PAK-12                 2            0              0               2      \n  INV ID PAK-13                 1            1              0               2      \n  INV ID PAK-14                 1            0              0               1      \n  INV ID PAK-15                 1            0              0               1      \n  INV ID PAK-2                  1            0              2               3      \n  INV ID PAK-4                  0            1              1               2      \n  INV ID PAK-5                  0            0              1               1      \nNGA                          8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n  INV ID NGA-1                  3            3              4               10     \n  INV ID NGA-11                 1            2              3               6      \n  INV ID NGA-12                 0            1              1               2      \n  INV ID NGA-17                 2            0              0               2      \n  INV ID NGA-2                  1            1              0               2      \n  INV ID NGA-4                  1            0              1               2      \n  INV ID NGA-5                  0            0              1               1      \n  INV ID NGA-6                  0            0              1               1      \nRUS                          5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n  INV ID RUS-1                  1            0              0               1      \n  INV ID RUS-11                 0            2              2               4      \n  INV ID RUS-12                 0            1              0               1      \n  INV ID RUS-13                 1            0              0               1      \n  INV ID RUS-14                 0            0              1               1      \n  INV ID RUS-16                 1            1              0               2      \n  INV ID RUS-18                 1            0              0               1      \n  INV ID RUS-2                  0            1              0               1      \n  INV ID RUS-3                  0            0              1               1      \n  INV ID RUS-4                  0            2              1               3      \n  INV ID RUS-5                  0            1              0               1      \n  INV ID RUS-6                  1            0              0               1      \n  INV ID RUS-7                  0            0              1               1      \nJPN                          5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  \n  INV ID JPN-1                  2            2              1               5      \n  INV ID JPN-11                 0            0              3               3      \n  INV ID JPN-12                 0            0              1               1      \n  INV ID JPN-14                 0            1              0               1      \n  INV ID JPN-17                 0            0              2               2      \n  INV ID JPN-18                 1            0              0               1      \n  INV ID JPN-2                  0            0              1               1      \n  INV ID JPN-3                  0            1              0               1      \n  INV ID JPN-5                  1            0              1               2      \n  INV ID JPN-6                  1            0              0               1      \nGBR                          4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n  INV ID GBR-1                  2            0              1               3      \n  INV ID GBR-11                 0            1              1               2      \n  INV ID GBR-13                 1            0              0               1      \n  INV ID GBR-15                 1            0              0               1      \n  INV ID GBR-17                 0            1              0               1      \n  INV ID GBR-6                  0            1              0               1      \nCAN                          3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  \n  INV ID CAN-1                  1            1              0               2      \n  INV ID CAN-11                 1            0              1               2      \n  INV ID CAN-14                 1            0              0               1      \n  INV ID CAN-4                  0            1              1               2      \n  INV ID CAN-5                  0            0              1               1      \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  split_rows_by(\"REGION1\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$REGION1)) %&gt;%\n  summarize_row_groups() %&gt;%\n  split_rows_by(\"COUNTRY\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$COUNTRY)) %&gt;%\n  summarize_row_groups() %&gt;%\n  analyze(\"INVID_INVNAM\") %&gt;%\n  append_varlabels(adsl, \"INVID_INVNAM\", 2L)\n\nresult &lt;- build_table(lyt, adsl) %&gt;%\n  prune_table()\n\nresult\n\nGeographic Region 1                                                                         \n  Country                            A: Drug X    B: Placebo   C: Combination   All Patients\n    Investigator Number/Name          (N=134)      (N=134)        (N=132)         (N=400)   \n————————————————————————————————————————————————————————————————————————————————————————————\nAfrica                                8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n  NGA                                 8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n    INV ID NGA-1 / Dr. NGA-1 Doe         3            3              4               10     \n    INV ID NGA-11 / Dr. NGA-11 Doe       1            2              3               6      \n    INV ID NGA-12 / Dr. NGA-12 Doe       0            1              1               2      \n    INV ID NGA-17 / Dr. NGA-17 Doe       2            0              0               2      \n    INV ID NGA-2 / Dr. NGA-2 Doe         1            1              0               2      \n    INV ID NGA-4 / Dr. NGA-4 Doe         1            0              1               2      \n    INV ID NGA-5 / Dr. NGA-5 Doe         0            0              1               1      \n    INV ID NGA-6 / Dr. NGA-6 Doe         0            0              1               1      \nAsia                                 91 (67.9%)   94 (70.1%)     83 (62.9%)     268 (67.0%) \n  CHN                                74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) \n    INV ID CHN-1 / Dr. CHN-1 Doe         21           20             16              57     \n    INV ID CHN-10 / Dr. CHN-10 Doe       0            1              0               1      \n    INV ID CHN-11 / Dr. CHN-11 Doe       12           20             16              48     \n    INV ID CHN-12 / Dr. CHN-12 Doe       4            3              1               8      \n    INV ID CHN-13 / Dr. CHN-13 Doe       2            6              0               8      \n    INV ID CHN-14 / Dr. CHN-14 Doe       4            2              3               9      \n    INV ID CHN-15 / Dr. CHN-15 Doe       2            0              4               6      \n    INV ID CHN-16 / Dr. CHN-16 Doe       0            3              3               6      \n    INV ID CHN-17 / Dr. CHN-17 Doe       4            4              3               11     \n    INV ID CHN-18 / Dr. CHN-18 Doe       1            0              2               3      \n    INV ID CHN-2 / Dr. CHN-2 Doe         9            4              3               16     \n    INV ID CHN-3 / Dr. CHN-3 Doe         5            1              5               11     \n    INV ID CHN-4 / Dr. CHN-4 Doe         3            3              3               9      \n    INV ID CHN-5 / Dr. CHN-5 Doe         4            3              4               11     \n    INV ID CHN-6 / Dr. CHN-6 Doe         1            3              0               4      \n    INV ID CHN-7 / Dr. CHN-7 Doe         0            5              1               6      \n    INV ID CHN-8 / Dr. CHN-8 Doe         1            1              0               2      \n    INV ID CHN-9 / Dr. CHN-9 Doe         1            2              0               3      \n  PAK                                12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  \n    INV ID PAK-1 / Dr. PAK-1 Doe         2            4              4               10     \n    INV ID PAK-11 / Dr. PAK-11 Doe       4            3              2               9      \n    INV ID PAK-12 / Dr. PAK-12 Doe       2            0              0               2      \n    INV ID PAK-13 / Dr. PAK-13 Doe       1            1              0               2      \n    INV ID PAK-14 / Dr. PAK-14 Doe       1            0              0               1      \n    INV ID PAK-15 / Dr. PAK-15 Doe       1            0              0               1      \n    INV ID PAK-2 / Dr. PAK-2 Doe         1            0              2               3      \n    INV ID PAK-4 / Dr. PAK-4 Doe         0            1              1               2      \n    INV ID PAK-5 / Dr. PAK-5 Doe         0            0              1               1      \n  JPN                                 5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  \n    INV ID JPN-1 / Dr. JPN-1 Doe         2            2              1               5      \n    INV ID JPN-11 / Dr. JPN-11 Doe       0            0              3               3      \n    INV ID JPN-12 / Dr. JPN-12 Doe       0            0              1               1      \n    INV ID JPN-14 / Dr. JPN-14 Doe       0            1              0               1      \n    INV ID JPN-17 / Dr. JPN-17 Doe       0            0              2               2      \n    INV ID JPN-18 / Dr. JPN-18 Doe       1            0              0               1      \n    INV ID JPN-2 / Dr. JPN-2 Doe         0            0              1               1      \n    INV ID JPN-3 / Dr. JPN-3 Doe         0            1              0               1      \n    INV ID JPN-5 / Dr. JPN-5 Doe         1            0              1               2      \n    INV ID JPN-6 / Dr. JPN-6 Doe         1            0              0               1      \nEurasia                               5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n  RUS                                 5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n    INV ID RUS-1 / Dr. RUS-1 Doe         1            0              0               1      \n    INV ID RUS-11 / Dr. RUS-11 Doe       0            2              2               4      \n    INV ID RUS-12 / Dr. RUS-12 Doe       0            1              0               1      \n    INV ID RUS-13 / Dr. RUS-13 Doe       1            0              0               1      \n    INV ID RUS-14 / Dr. RUS-14 Doe       0            0              1               1      \n    INV ID RUS-16 / Dr. RUS-16 Doe       1            1              0               2      \n    INV ID RUS-18 / Dr. RUS-18 Doe       1            0              0               1      \n    INV ID RUS-2 / Dr. RUS-2 Doe         0            1              0               1      \n    INV ID RUS-3 / Dr. RUS-3 Doe         0            0              1               1      \n    INV ID RUS-4 / Dr. RUS-4 Doe         0            2              1               3      \n    INV ID RUS-5 / Dr. RUS-5 Doe         0            1              0               1      \n    INV ID RUS-6 / Dr. RUS-6 Doe         1            0              0               1      \n    INV ID RUS-7 / Dr. RUS-7 Doe         0            0              1               1      \nEurope                                4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n  GBR                                 4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n    INV ID GBR-1 / Dr. GBR-1 Doe         2            0              1               3      \n    INV ID GBR-11 / Dr. GBR-11 Doe       0            1              1               2      \n    INV ID GBR-13 / Dr. GBR-13 Doe       1            0              0               1      \n    INV ID GBR-15 / Dr. GBR-15 Doe       1            0              0               1      \n    INV ID GBR-17 / Dr. GBR-17 Doe       0            1              0               1      \n    INV ID GBR-6 / Dr. GBR-6 Doe         0            1              0               1      \nNorth America                        13 (9.7%)    15 (11.2%)     20 (15.2%)      48 (12.0%) \n  USA                                10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) \n    INV ID USA-1 / Dr. USA-1 Doe         1            4              5               10     \n    INV ID USA-11 / Dr. USA-11 Doe       4            2              3               9      \n    INV ID USA-12 / Dr. USA-12 Doe       1            2              3               6      \n    INV ID USA-14 / Dr. USA-14 Doe       1            0              0               1      \n    INV ID USA-15 / Dr. USA-15 Doe       0            1              1               2      \n    INV ID USA-17 / Dr. USA-17 Doe       1            1              0               2      \n    INV ID USA-19 / Dr. USA-19 Doe       0            0              1               1      \n    INV ID USA-2 / Dr. USA-2 Doe         0            0              1               1      \n    INV ID USA-3 / Dr. USA-3 Doe         1            0              1               2      \n    INV ID USA-4 / Dr. USA-4 Doe         0            1              1               2      \n    INV ID USA-5 / Dr. USA-5 Doe         0            1              0               1      \n    INV ID USA-6 / Dr. USA-6 Doe         0            1              0               1      \n    INV ID USA-8 / Dr. USA-8 Doe         0            0              1               1      \n    INV ID USA-9 / Dr. USA-9 Doe         1            0              0               1      \n  CAN                                 3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  \n    INV ID CAN-1 / Dr. CAN-1 Doe         1            1              0               2      \n    INV ID CAN-11 / Dr. CAN-11 Doe       1            0              1               2      \n    INV ID CAN-14 / Dr. CAN-14 Doe       1            0              0               1      \n    INV ID CAN-4 / Dr. CAN-4 Doe         0            1              1               2      \n    INV ID CAN-5 / Dr. CAN-5 Doe         0            0              1               1      \nSouth America                        13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n  BRA                                13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n    INV ID BRA-1 / Dr. BRA-1 Doe         4            2              2               8      \n    INV ID BRA-11 / Dr. BRA-11 Doe       4            0              4               8      \n    INV ID BRA-12 / Dr. BRA-12 Doe       0            1              0               1      \n    INV ID BRA-13 / Dr. BRA-13 Doe       1            0              0               1      \n    INV ID BRA-14 / Dr. BRA-14 Doe       1            0              1               2      \n    INV ID BRA-15 / Dr. BRA-15 Doe       1            0              0               1      \n    INV ID BRA-2 / Dr. BRA-2 Doe         1            1              0               2      \n    INV ID BRA-3 / Dr. BRA-3 Doe         0            2              0               2      \n    INV ID BRA-4 / Dr. BRA-4 Doe         0            1              1               2      \n    INV ID BRA-5 / Dr. BRA-5 Doe         0            0              1               1      \n    INV ID BRA-6 / Dr. BRA-6 Doe         1            0              0               1      \n    INV ID BRA-7 / Dr. BRA-7 Doe         0            0              1               1      \n\n\n\n\n\nCodelyt &lt;- basic_table(show_colcounts = TRUE) %&gt;%\n  split_cols_by(\"ARM\") %&gt;%\n  add_overall_col(label = \"All Patients\") %&gt;%\n  split_rows_by(\"COUNTRY\", split_fun = split_fun, label_pos = \"topleft\", split_label = obj_label(adsl$COUNTRY)) %&gt;%\n  summarize_row_groups() %&gt;%\n  analyze(\"INVID_INVNAM\") %&gt;%\n  append_varlabels(adsl, \"INVID_INVNAM\", 1L)\n\nresult &lt;- build_table(lyt, adsl) %&gt;%\n  prune_table()\n\nresult\n\nCountry                            A: Drug X    B: Placebo   C: Combination   All Patients\n  Investigator Number/Name          (N=134)      (N=134)        (N=132)         (N=400)   \n——————————————————————————————————————————————————————————————————————————————————————————\nCHN                                74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) \n  INV ID CHN-1 / Dr. CHN-1 Doe         21           20             16              57     \n  INV ID CHN-10 / Dr. CHN-10 Doe       0            1              0               1      \n  INV ID CHN-11 / Dr. CHN-11 Doe       12           20             16              48     \n  INV ID CHN-12 / Dr. CHN-12 Doe       4            3              1               8      \n  INV ID CHN-13 / Dr. CHN-13 Doe       2            6              0               8      \n  INV ID CHN-14 / Dr. CHN-14 Doe       4            2              3               9      \n  INV ID CHN-15 / Dr. CHN-15 Doe       2            0              4               6      \n  INV ID CHN-16 / Dr. CHN-16 Doe       0            3              3               6      \n  INV ID CHN-17 / Dr. CHN-17 Doe       4            4              3               11     \n  INV ID CHN-18 / Dr. CHN-18 Doe       1            0              2               3      \n  INV ID CHN-2 / Dr. CHN-2 Doe         9            4              3               16     \n  INV ID CHN-3 / Dr. CHN-3 Doe         5            1              5               11     \n  INV ID CHN-4 / Dr. CHN-4 Doe         3            3              3               9      \n  INV ID CHN-5 / Dr. CHN-5 Doe         4            3              4               11     \n  INV ID CHN-6 / Dr. CHN-6 Doe         1            3              0               4      \n  INV ID CHN-7 / Dr. CHN-7 Doe         0            5              1               6      \n  INV ID CHN-8 / Dr. CHN-8 Doe         1            1              0               2      \n  INV ID CHN-9 / Dr. CHN-9 Doe         1            2              0               3      \nUSA                                10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) \n  INV ID USA-1 / Dr. USA-1 Doe         1            4              5               10     \n  INV ID USA-11 / Dr. USA-11 Doe       4            2              3               9      \n  INV ID USA-12 / Dr. USA-12 Doe       1            2              3               6      \n  INV ID USA-14 / Dr. USA-14 Doe       1            0              0               1      \n  INV ID USA-15 / Dr. USA-15 Doe       0            1              1               2      \n  INV ID USA-17 / Dr. USA-17 Doe       1            1              0               2      \n  INV ID USA-19 / Dr. USA-19 Doe       0            0              1               1      \n  INV ID USA-2 / Dr. USA-2 Doe         0            0              1               1      \n  INV ID USA-3 / Dr. USA-3 Doe         1            0              1               2      \n  INV ID USA-4 / Dr. USA-4 Doe         0            1              1               2      \n  INV ID USA-5 / Dr. USA-5 Doe         0            1              0               1      \n  INV ID USA-6 / Dr. USA-6 Doe         0            1              0               1      \n  INV ID USA-8 / Dr. USA-8 Doe         0            0              1               1      \n  INV ID USA-9 / Dr. USA-9 Doe         1            0              0               1      \nBRA                                13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  \n  INV ID BRA-1 / Dr. BRA-1 Doe         4            2              2               8      \n  INV ID BRA-11 / Dr. BRA-11 Doe       4            0              4               8      \n  INV ID BRA-12 / Dr. BRA-12 Doe       0            1              0               1      \n  INV ID BRA-13 / Dr. BRA-13 Doe       1            0              0               1      \n  INV ID BRA-14 / Dr. BRA-14 Doe       1            0              1               2      \n  INV ID BRA-15 / Dr. BRA-15 Doe       1            0              0               1      \n  INV ID BRA-2 / Dr. BRA-2 Doe         1            1              0               2      \n  INV ID BRA-3 / Dr. BRA-3 Doe         0            2              0               2      \n  INV ID BRA-4 / Dr. BRA-4 Doe         0            1              1               2      \n  INV ID BRA-5 / Dr. BRA-5 Doe         0            0              1               1      \n  INV ID BRA-6 / Dr. BRA-6 Doe         1            0              0               1      \n  INV ID BRA-7 / Dr. BRA-7 Doe         0            0              1               1      \nPAK                                12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  \n  INV ID PAK-1 / Dr. PAK-1 Doe         2            4              4               10     \n  INV ID PAK-11 / Dr. PAK-11 Doe       4            3              2               9      \n  INV ID PAK-12 / Dr. PAK-12 Doe       2            0              0               2      \n  INV ID PAK-13 / Dr. PAK-13 Doe       1            1              0               2      \n  INV ID PAK-14 / Dr. PAK-14 Doe       1            0              0               1      \n  INV ID PAK-15 / Dr. PAK-15 Doe       1            0              0               1      \n  INV ID PAK-2 / Dr. PAK-2 Doe         1            0              2               3      \n  INV ID PAK-4 / Dr. PAK-4 Doe         0            1              1               2      \n  INV ID PAK-5 / Dr. PAK-5 Doe         0            0              1               1      \nNGA                                 8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  \n  INV ID NGA-1 / Dr. NGA-1 Doe         3            3              4               10     \n  INV ID NGA-11 / Dr. NGA-11 Doe       1            2              3               6      \n  INV ID NGA-12 / Dr. NGA-12 Doe       0            1              1               2      \n  INV ID NGA-17 / Dr. NGA-17 Doe       2            0              0               2      \n  INV ID NGA-2 / Dr. NGA-2 Doe         1            1              0               2      \n  INV ID NGA-4 / Dr. NGA-4 Doe         1            0              1               2      \n  INV ID NGA-5 / Dr. NGA-5 Doe         0            0              1               1      \n  INV ID NGA-6 / Dr. NGA-6 Doe         0            0              1               1      \nRUS                                 5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  \n  INV ID RUS-1 / Dr. RUS-1 Doe         1            0              0               1      \n  INV ID RUS-11 / Dr. RUS-11 Doe       0            2              2               4      \n  INV ID RUS-12 / Dr. RUS-12 Doe       0            1              0               1      \n  INV ID RUS-13 / Dr. RUS-13 Doe       1            0              0               1      \n  INV ID RUS-14 / Dr. RUS-14 Doe       0            0              1               1      \n  INV ID RUS-16 / Dr. RUS-16 Doe       1            1              0               2      \n  INV ID RUS-18 / Dr. RUS-18 Doe       1            0              0               1      \n  INV ID RUS-2 / Dr. RUS-2 Doe         0            1              0               1      \n  INV ID RUS-3 / Dr. RUS-3 Doe         0            0              1               1      \n  INV ID RUS-4 / Dr. RUS-4 Doe         0            2              1               3      \n  INV ID RUS-5 / Dr. RUS-5 Doe         0            1              0               1      \n  INV ID RUS-6 / Dr. RUS-6 Doe         1            0              0               1      \n  INV ID RUS-7 / Dr. RUS-7 Doe         0            0              1               1      \nJPN                                 5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  \n  INV ID JPN-1 / Dr. JPN-1 Doe         2            2              1               5      \n  INV ID JPN-11 / Dr. JPN-11 Doe       0            0              3               3      \n  INV ID JPN-12 / Dr. JPN-12 Doe       0            0              1               1      \n  INV ID JPN-14 / Dr. JPN-14 Doe       0            1              0               1      \n  INV ID JPN-17 / Dr. JPN-17 Doe       0            0              2               2      \n  INV ID JPN-18 / Dr. JPN-18 Doe       1            0              0               1      \n  INV ID JPN-2 / Dr. JPN-2 Doe         0            0              1               1      \n  INV ID JPN-3 / Dr. JPN-3 Doe         0            1              0               1      \n  INV ID JPN-5 / Dr. JPN-5 Doe         1            0              1               2      \n  INV ID JPN-6 / Dr. JPN-6 Doe         1            0              0               1      \nGBR                                 4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  \n  INV ID GBR-1 / Dr. GBR-1 Doe         2            0              1               3      \n  INV ID GBR-11 / Dr. GBR-11 Doe       0            1              1               2      \n  INV ID GBR-13 / Dr. GBR-13 Doe       1            0              0               1      \n  INV ID GBR-15 / Dr. GBR-15 Doe       1            0              0               1      \n  INV ID GBR-17 / Dr. GBR-17 Doe       0            1              0               1      \n  INV ID GBR-6 / Dr. GBR-6 Doe         0            1              0               1      \nCAN                                 3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  \n  INV ID CAN-1 / Dr. CAN-1 Doe         1            1              0               2      \n  INV ID CAN-11 / Dr. CAN-11 Doe       1            0              1               2      \n  INV ID CAN-14 / Dr. CAN-14 Doe       1            0              0               1      \n  INV ID CAN-4 / Dr. CAN-4 Doe         0            1              1               2      \n  INV ID CAN-5 / Dr. CAN-5 Doe         0            0              1               1      \n\n\n\n\nNote that for this module application, only the variables passed into by_vars are used when row_groups is selected. Variables passed into analyze_vars are additionally used when row_groups is deselected.\n\nCodelibrary(dplyr)\nlibrary(forcats)\nlibrary(scda)\nlibrary(teal.modules.clinical)\n\nadsl &lt;- synthetic_cdisc_dataset(\"latest\", \"adsl\")\n\n# Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.\nadsl &lt;- df_explicit_na(adsl)\n\nadsl_labels &lt;- var_labels(adsl)\n\nadsl &lt;- adsl %&gt;%\n  mutate(\n    REGION1 = droplevels(REGION1),\n    COUNTRY = droplevels(COUNTRY),\n    INVID_INVNAM = paste(INVID, INVNAM, sep = \" / \")\n  ) %&gt;%\n  arrange(REGION1, COUNTRY, INVID) %&gt;%\n  mutate(\n    INVID = factor(INVID),\n    SITEID = factor(SITEID),\n    INVNAM = factor(INVNAM),\n    INVID_INVNAM = factor(INVID_INVNAM)\n  )\n\nvar_labels(adsl) &lt;- c(adsl_labels, \"Investigator Number/Name\")\n\napp &lt;- init(\n  data = cdisc_data(\n    cdisc_dataset(\"ADSL\", adsl,\n      code = 'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset(\"latest\", \"adsl\"))\n                  ADSL_labels &lt;- var_labels(ADSL)\n                  ADSL &lt;- ADSL %&gt;% mutate(\n                    REGION1 = droplevels(REGION1),\n                    COUNTRY = droplevels(COUNTRY),\n                    INVID_INVNAM = paste(INVID, INVNAM, sep = \" / \")\n                  ) %&gt;%\n                    arrange(REGION1, COUNTRY, INVID) %&gt;%\n                    mutate(\n                      INVID = factor(INVID),\n                      SITEID = factor(SITEID),\n                      INVNAM = factor(INVNAM),\n                      INVID_INVNAM = factor(INVID_INVNAM)\n                    )\n\n                  var_labels(ADSL) &lt;- c(ADSL_labels, \"Investigator Number/Name\")'\n    ),\n    check = TRUE\n  ),\n  modules = modules(\n    tm_t_summary_by(\n      label = \"Enrollment Table\",\n      dataname = \"ADSL\",\n      arm_var = choices_selected(\n        choices = variable_choices(adsl, c(\"ARM\", \"ARMCD\")),\n        selected = \"ARM\"\n      ),\n      by_vars = choices_selected(\n        choices = variable_choices(adsl, c(\"REGION1\", \"COUNTRY\", \"SITEID\", \"INVID\", \"INVNAM\", \"INVID_INVNAM\")),\n        selected = c(\"REGION1\")\n      ),\n      summarize_vars = choices_selected(\n        choices = variable_choices(adsl, c(\"REGION1\", \"COUNTRY\", \"SITEID\", \"INVID\", \"INVNAM\", \"INVID_INVNAM\")),\n        selected = c(\"SITEID\")\n      ),\n      denominator = choices_selected(\n        choices = c(\"n\", \"N\", \"omit\"),\n        selected = \"N\",\n        fixed = TRUE\n      ),\n      useNA = \"ifany\",\n      row_groups = TRUE\n    )\n  )\n)\n\n[INFO] 2023-09-25 11:37:53.7358 pid:14074 token:[] teal.modules.clinical Initializing tm_t_summary_by\n\nCodeshinyApp(app$ui, app$server)\n\n\n\n\n\n\nSession Info\n\nCodesessionInfo()\n\nR version 4.3.1 (2023-06-16)\nPlatform: x86_64-pc-linux-gnu (64-bit)\nRunning under: Ubuntu 22.04.3 LTS\n\nMatrix products: default\nBLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 \nLAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0\n\nlocale:\n [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              \n [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    \n [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   \n [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 \n [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       \n\ntime zone: Etc/UTC\ntzcode source: system (glibc)\n\nattached base packages:\n[1] stats     graphics  grDevices utils     datasets  methods   base     \n\nother attached packages:\n [1] teal.modules.clinical_0.8.16 teal_0.14.0                 \n [3] teal.transform_0.4.0         teal.slice_0.4.0            \n [5] teal.data_0.3.0              shiny_1.7.5                 \n [7] tern_0.9.0                   rtables_0.6.3               \n [9] magrittr_2.0.3               formatters_0.5.2            \n[11] scda_0.1.6                   forcats_1.0.0               \n[13] dplyr_1.1.3                 \n\nloaded via a namespace (and not attached):\n [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        \n [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        \n [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       \n[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       \n[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          \n[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           \n[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    \n[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   \n[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          \n[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     \n[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         \n[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        \n[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    \n[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     \n[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       \n[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          \n[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    \n[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           \n[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         \n[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        \n[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         \n[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             \n[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       \n[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        \n[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        \n[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          \n[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            \n[82] zoo_1.8-12            pkgconfig_2.0.3      \n\n\n\n.lock file\nDownload the .lock file and use renv::restore() on it to recreate environment used to generate this website.\n\nCodeparent_file_path &lt;- knitr::current_input(dir = TRUE)\n\nbook_root_dir &lt;- parent_file_path\nwhile (!file.exists(file.path(book_root_dir, \"_quarto.yml\"))) book_root_dir &lt;- dirname(book_root_dir)\n\nlock_path &lt;- file.path(\"../../assets/www/lock\", paste0(gsub(file.path(book_root_dir, \"\"), \"\", gsub(\"\\\\.rmarkdown$\", \"\", knitr::current_input(dir = TRUE))), \".lock\"))\n\nwithr::with_options(\n  list(renv.verbose = FALSE),\n  renv::snapshot(parent_file_path, lockfile = lock_path, prompt = FALSE, force = TRUE)\n)\n\n\nDownload"
+  }
+]
\ No newline at end of file
diff --git a/stable/site_libs/bootstrap/bootstrap-dark.min.css b/stable/site_libs/bootstrap/bootstrap-dark.min.css
new file mode 100644
index 0000000000..a2f590e7a5
--- /dev/null
+++ b/stable/site_libs/bootstrap/bootstrap-dark.min.css
@@ -0,0 +1,10 @@
+/*!
+ * Bootstrap v5.1.3 (https://getbootstrap.com/)
+ * Copyright 2011-2021 The Bootstrap Authors
+ * Copyright 2011-2021 Twitter, Inc.
+ * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+ */@import"https://fonts.googleapis.com/css2?family=Lato:ital,wght@0,400;0,700;1,400&display=swap";:root{--bs-blue: #375a7f;--bs-indigo: #6610f2;--bs-purple: #6f42c1;--bs-pink: #e83e8c;--bs-red: #e74c3c;--bs-orange: #fd7e14;--bs-yellow: #f39c12;--bs-green: #00bc8c;--bs-teal: #20c997;--bs-cyan: #3498db;--bs-white: #fff;--bs-gray: #6c757d;--bs-gray-dark: #303030;--bs-gray-100: #f8f9fa;--bs-gray-200: #ebebeb;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #adb5bd;--bs-gray-600: #6c757d;--bs-gray-700: #444;--bs-gray-800: #303030;--bs-gray-900: #222;--bs-default: #434343;--bs-primary: #375a7f;--bs-secondary: #434343;--bs-success: #00bc8c;--bs-info: #3498db;--bs-warning: #f39c12;--bs-danger: #e74c3c;--bs-light: #6f6f6f;--bs-dark: #2d2d2d;--bs-default-rgb: 67, 67, 67;--bs-primary-rgb: 55, 90, 127;--bs-secondary-rgb: 67, 67, 67;--bs-success-rgb: 0, 188, 140;--bs-info-rgb: 52, 152, 219;--bs-warning-rgb: 243, 156, 18;--bs-danger-rgb: 231, 76, 60;--bs-light-rgb: 111, 111, 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991.98px){.quarto-title-banner{padding-top:1em;padding-bottom:1em}}main.quarto-banner-title-block>section:first-child>h2,main.quarto-banner-title-block>section:first-child>.h2,main.quarto-banner-title-block>section:first-child>h3,main.quarto-banner-title-block>section:first-child>.h3,main.quarto-banner-title-block>section:first-child>h4,main.quarto-banner-title-block>section:first-child>.h4{margin-top:0}.quarto-title .quarto-categories{display:flex;flex-wrap:wrap;row-gap:.5em;column-gap:.4em;padding-bottom:.5em;margin-top:.75em}.quarto-title .quarto-categories .quarto-category{padding:.25em .75em;font-size:.65em;text-transform:uppercase;border:solid 1px;border-radius:.25rem;opacity:.6}.quarto-title .quarto-categories .quarto-category a{color:inherit}#title-block-header.quarto-title-block.default .quarto-title-meta{display:grid;grid-template-columns:repeat(2, 1fr)}#title-block-header.quarto-title-block.default .quarto-title .title{margin-bottom:0}#title-block-header.quarto-title-block.default .quarto-title-author-orcid img{margin-top:-5px}#title-block-header.quarto-title-block.default .quarto-description p:last-of-type{margin-bottom:0}#title-block-header.quarto-title-block.default .quarto-title-meta-contents p,#title-block-header.quarto-title-block.default .quarto-title-authors p,#title-block-header.quarto-title-block.default .quarto-title-affiliations p{margin-bottom:.1em}#title-block-header.quarto-title-block.default .quarto-title-meta-heading{text-transform:uppercase;margin-top:1em;font-size:.8em;opacity:.8;font-weight:400}#title-block-header.quarto-title-block.default .quarto-title-meta-contents{font-size:.9em}#title-block-header.quarto-title-block.default .quarto-title-meta-contents a{color:#fff}#title-block-header.quarto-title-block.default .quarto-title-meta-contents p.affiliation:last-of-type{margin-bottom:.7em}#title-block-header.quarto-title-block.default p.affiliation{margin-bottom:.1em}#title-block-header.quarto-title-block.default .description,#title-block-header.quarto-title-block.default .abstract{margin-top:0}#title-block-header.quarto-title-block.default .description>p,#title-block-header.quarto-title-block.default .abstract>p{font-size:.9em}#title-block-header.quarto-title-block.default .description>p:last-of-type,#title-block-header.quarto-title-block.default .abstract>p:last-of-type{margin-bottom:0}#title-block-header.quarto-title-block.default .description .abstract-title,#title-block-header.quarto-title-block.default .abstract .abstract-title{margin-top:1em;text-transform:uppercase;font-size:.8em;opacity:.8;font-weight:400}#title-block-header.quarto-title-block.default .quarto-title-meta-author{display:grid;grid-template-columns:1fr 1fr}.quarto-title-tools-only{display:flex;justify-content:right}/*# sourceMappingURL=945575463e70190d99eb671cb8520afc.css.map */
diff --git a/stable/site_libs/bootstrap/bootstrap-icons.css b/stable/site_libs/bootstrap/bootstrap-icons.css
new file mode 100644
index 0000000000..94f1940448
--- /dev/null
+++ b/stable/site_libs/bootstrap/bootstrap-icons.css
@@ -0,0 +1,2018 @@
+@font-face {
+  font-display: block;
+  font-family: "bootstrap-icons";
+  src: 
+url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
+}
+
+.bi::before,
+[class^="bi-"]::before,
+[class*=" bi-"]::before {
+  display: inline-block;
+  font-family: bootstrap-icons !important;
+  font-style: normal;
+  font-weight: normal !important;
+  font-variant: normal;
+  text-transform: none;
+  line-height: 1;
+  vertical-align: -.125em;
+  -webkit-font-smoothing: antialiased;
+  -moz-osx-font-smoothing: grayscale;
+}
+
+.bi-123::before { content: "\f67f"; }
+.bi-alarm-fill::before { content: "\f101"; }
+.bi-alarm::before { content: "\f102"; }
+.bi-align-bottom::before { content: "\f103"; }
+.bi-align-center::before { content: "\f104"; }
+.bi-align-end::before { content: "\f105"; }
+.bi-align-middle::before { content: "\f106"; }
+.bi-align-start::before { content: "\f107"; }
+.bi-align-top::before { content: "\f108"; }
+.bi-alt::before { content: "\f109"; }
+.bi-app-indicator::before { content: "\f10a"; }
+.bi-app::before { content: "\f10b"; }
+.bi-archive-fill::before { content: "\f10c"; }
+.bi-archive::before { content: "\f10d"; }
+.bi-arrow-90deg-down::before { content: "\f10e"; }
+.bi-arrow-90deg-left::before { content: "\f10f"; }
+.bi-arrow-90deg-right::before { content: "\f110"; }
+.bi-arrow-90deg-up::before { content: "\f111"; }
+.bi-arrow-bar-down::before { content: "\f112"; }
+.bi-arrow-bar-left::before { content: "\f113"; }
+.bi-arrow-bar-right::before { content: "\f114"; }
+.bi-arrow-bar-up::before { content: "\f115"; }
+.bi-arrow-clockwise::before { content: "\f116"; }
+.bi-arrow-counterclockwise::before { content: "\f117"; }
+.bi-arrow-down-circle-fill::before { content: "\f118"; }
+.bi-arrow-down-circle::before { content: "\f119"; }
+.bi-arrow-down-left-circle-fill::before { content: "\f11a"; }
+.bi-arrow-down-left-circle::before { content: "\f11b"; }
+.bi-arrow-down-left-square-fill::before { content: "\f11c"; }
+.bi-arrow-down-left-square::before { content: "\f11d"; }
+.bi-arrow-down-left::before { content: "\f11e"; }
+.bi-arrow-down-right-circle-fill::before { content: "\f11f"; }
+.bi-arrow-down-right-circle::before { content: "\f120"; }
+.bi-arrow-down-right-square-fill::before { content: "\f121"; }
+.bi-arrow-down-right-square::before { content: "\f122"; }
+.bi-arrow-down-right::before { content: "\f123"; }
+.bi-arrow-down-short::before { content: "\f124"; }
+.bi-arrow-down-square-fill::before { content: "\f125"; }
+.bi-arrow-down-square::before { content: "\f126"; }
+.bi-arrow-down-up::before { content: "\f127"; }
+.bi-arrow-down::before { content: "\f128"; }
+.bi-arrow-left-circle-fill::before { content: "\f129"; }
+.bi-arrow-left-circle::before { content: "\f12a"; }
+.bi-arrow-left-right::before { content: "\f12b"; }
+.bi-arrow-left-short::before { content: "\f12c"; }
+.bi-arrow-left-square-fill::before { content: "\f12d"; }
+.bi-arrow-left-square::before { content: "\f12e"; }
+.bi-arrow-left::before { content: "\f12f"; }
+.bi-arrow-repeat::before { content: "\f130"; }
+.bi-arrow-return-left::before { content: "\f131"; }
+.bi-arrow-return-right::before { content: "\f132"; }
+.bi-arrow-right-circle-fill::before { content: "\f133"; }
+.bi-arrow-right-circle::before { content: "\f134"; }
+.bi-arrow-right-short::before { content: "\f135"; }
+.bi-arrow-right-square-fill::before { content: "\f136"; }
+.bi-arrow-right-square::before { content: "\f137"; }
+.bi-arrow-right::before { content: "\f138"; }
+.bi-arrow-up-circle-fill::before { content: "\f139"; }
+.bi-arrow-up-circle::before { content: "\f13a"; }
+.bi-arrow-up-left-circle-fill::before { content: "\f13b"; }
+.bi-arrow-up-left-circle::before { content: "\f13c"; }
+.bi-arrow-up-left-square-fill::before { content: "\f13d"; }
+.bi-arrow-up-left-square::before { content: "\f13e"; }
+.bi-arrow-up-left::before { content: "\f13f"; }
+.bi-arrow-up-right-circle-fill::before { content: "\f140"; }
+.bi-arrow-up-right-circle::before { content: "\f141"; }
+.bi-arrow-up-right-square-fill::before { content: "\f142"; }
+.bi-arrow-up-right-square::before { content: "\f143"; }
+.bi-arrow-up-right::before { content: "\f144"; }
+.bi-arrow-up-short::before { content: "\f145"; }
+.bi-arrow-up-square-fill::before { content: "\f146"; }
+.bi-arrow-up-square::before { content: "\f147"; }
+.bi-arrow-up::before { content: "\f148"; }
+.bi-arrows-angle-contract::before { content: "\f149"; }
+.bi-arrows-angle-expand::before { content: "\f14a"; }
+.bi-arrows-collapse::before { content: "\f14b"; }
+.bi-arrows-expand::before { content: "\f14c"; }
+.bi-arrows-fullscreen::before { content: "\f14d"; }
+.bi-arrows-move::before { content: "\f14e"; }
+.bi-aspect-ratio-fill::before { content: "\f14f"; }
+.bi-aspect-ratio::before { content: "\f150"; }
+.bi-asterisk::before { content: "\f151"; }
+.bi-at::before { content: "\f152"; }
+.bi-award-fill::before { content: "\f153"; }
+.bi-award::before { content: "\f154"; }
+.bi-back::before { content: "\f155"; }
+.bi-backspace-fill::before { content: "\f156"; }
+.bi-backspace-reverse-fill::before { content: "\f157"; }
+.bi-backspace-reverse::before { content: "\f158"; }
+.bi-backspace::before { content: "\f159"; }
+.bi-badge-3d-fill::before { content: "\f15a"; }
+.bi-badge-3d::before { content: "\f15b"; }
+.bi-badge-4k-fill::before { content: "\f15c"; }
+.bi-badge-4k::before { content: "\f15d"; }
+.bi-badge-8k-fill::before { content: "\f15e"; }
+.bi-badge-8k::before { content: "\f15f"; }
+.bi-badge-ad-fill::before { content: "\f160"; }
+.bi-badge-ad::before { content: "\f161"; }
+.bi-badge-ar-fill::before { content: "\f162"; }
+.bi-badge-ar::before { content: "\f163"; }
+.bi-badge-cc-fill::before { content: "\f164"; }
+.bi-badge-cc::before { content: "\f165"; }
+.bi-badge-hd-fill::before { content: "\f166"; }
+.bi-badge-hd::before { content: "\f167"; }
+.bi-badge-tm-fill::before { content: "\f168"; }
+.bi-badge-tm::before { content: "\f169"; }
+.bi-badge-vo-fill::before { content: "\f16a"; }
+.bi-badge-vo::before { content: "\f16b"; }
+.bi-badge-vr-fill::before { content: "\f16c"; }
+.bi-badge-vr::before { content: "\f16d"; }
+.bi-badge-wc-fill::before { content: "\f16e"; }
+.bi-badge-wc::before { content: "\f16f"; }
+.bi-bag-check-fill::before { content: "\f170"; }
+.bi-bag-check::before { content: "\f171"; }
+.bi-bag-dash-fill::before { content: "\f172"; }
+.bi-bag-dash::before { content: "\f173"; }
+.bi-bag-fill::before { content: "\f174"; }
+.bi-bag-plus-fill::before { content: "\f175"; }
+.bi-bag-plus::before { content: "\f176"; }
+.bi-bag-x-fill::before { content: "\f177"; }
+.bi-bag-x::before { content: "\f178"; }
+.bi-bag::before { content: "\f179"; }
+.bi-bar-chart-fill::before { content: "\f17a"; }
+.bi-bar-chart-line-fill::before { content: "\f17b"; }
+.bi-bar-chart-line::before { content: "\f17c"; }
+.bi-bar-chart-steps::before { content: "\f17d"; }
+.bi-bar-chart::before { content: "\f17e"; }
+.bi-basket-fill::before { content: "\f17f"; }
+.bi-basket::before { content: "\f180"; }
+.bi-basket2-fill::before { content: "\f181"; }
+.bi-basket2::before { content: "\f182"; }
+.bi-basket3-fill::before { content: "\f183"; }
+.bi-basket3::before { content: "\f184"; }
+.bi-battery-charging::before { content: "\f185"; }
+.bi-battery-full::before { content: "\f186"; }
+.bi-battery-half::before { content: "\f187"; }
+.bi-battery::before { content: "\f188"; }
+.bi-bell-fill::before { content: "\f189"; }
+.bi-bell::before { content: "\f18a"; }
+.bi-bezier::before { content: "\f18b"; }
+.bi-bezier2::before { content: "\f18c"; }
+.bi-bicycle::before { content: "\f18d"; }
+.bi-binoculars-fill::before { content: "\f18e"; }
+.bi-binoculars::before { content: "\f18f"; }
+.bi-blockquote-left::before { content: "\f190"; }
+.bi-blockquote-right::before { content: "\f191"; }
+.bi-book-fill::before { content: "\f192"; }
+.bi-book-half::before { content: "\f193"; }
+.bi-book::before { content: "\f194"; }
+.bi-bookmark-check-fill::before { content: "\f195"; }
+.bi-bookmark-check::before { content: "\f196"; }
+.bi-bookmark-dash-fill::before { content: "\f197"; }
+.bi-bookmark-dash::before { content: "\f198"; }
+.bi-bookmark-fill::before { content: "\f199"; }
+.bi-bookmark-heart-fill::before { content: "\f19a"; }
+.bi-bookmark-heart::before { content: "\f19b"; }
+.bi-bookmark-plus-fill::before { content: "\f19c"; }
+.bi-bookmark-plus::before { content: "\f19d"; }
+.bi-bookmark-star-fill::before { content: "\f19e"; }
+.bi-bookmark-star::before { content: "\f19f"; }
+.bi-bookmark-x-fill::before { content: "\f1a0"; }
+.bi-bookmark-x::before { content: "\f1a1"; }
+.bi-bookmark::before { content: "\f1a2"; }
+.bi-bookmarks-fill::before { content: "\f1a3"; }
+.bi-bookmarks::before { content: "\f1a4"; }
+.bi-bookshelf::before { content: "\f1a5"; }
+.bi-bootstrap-fill::before { content: "\f1a6"; }
+.bi-bootstrap-reboot::before { content: "\f1a7"; }
+.bi-bootstrap::before { content: "\f1a8"; }
+.bi-border-all::before { content: "\f1a9"; }
+.bi-border-bottom::before { content: "\f1aa"; }
+.bi-border-center::before { content: "\f1ab"; }
+.bi-border-inner::before { content: "\f1ac"; }
+.bi-border-left::before { content: "\f1ad"; }
+.bi-border-middle::before { content: "\f1ae"; }
+.bi-border-outer::before { content: "\f1af"; }
+.bi-border-right::before { content: "\f1b0"; }
+.bi-border-style::before { content: "\f1b1"; }
+.bi-border-top::before { content: "\f1b2"; }
+.bi-border-width::before { content: "\f1b3"; }
+.bi-border::before { content: "\f1b4"; }
+.bi-bounding-box-circles::before { content: "\f1b5"; }
+.bi-bounding-box::before { content: "\f1b6"; }
+.bi-box-arrow-down-left::before { content: "\f1b7"; }
+.bi-box-arrow-down-right::before { content: "\f1b8"; }
+.bi-box-arrow-down::before { content: "\f1b9"; }
+.bi-box-arrow-in-down-left::before { content: "\f1ba"; }
+.bi-box-arrow-in-down-right::before { content: "\f1bb"; }
+.bi-box-arrow-in-down::before { content: "\f1bc"; }
+.bi-box-arrow-in-left::before { content: "\f1bd"; }
+.bi-box-arrow-in-right::before { content: "\f1be"; }
+.bi-box-arrow-in-up-left::before { content: "\f1bf"; }
+.bi-box-arrow-in-up-right::before { content: "\f1c0"; }
+.bi-box-arrow-in-up::before { content: "\f1c1"; }
+.bi-box-arrow-left::before { content: "\f1c2"; }
+.bi-box-arrow-right::before { content: "\f1c3"; }
+.bi-box-arrow-up-left::before { content: "\f1c4"; }
+.bi-box-arrow-up-right::before { content: "\f1c5"; }
+.bi-box-arrow-up::before { content: "\f1c6"; }
+.bi-box-seam::before { content: "\f1c7"; }
+.bi-box::before { content: "\f1c8"; }
+.bi-braces::before { content: "\f1c9"; }
+.bi-bricks::before { content: "\f1ca"; }
+.bi-briefcase-fill::before { content: "\f1cb"; }
+.bi-briefcase::before { content: "\f1cc"; }
+.bi-brightness-alt-high-fill::before { content: "\f1cd"; }
+.bi-brightness-alt-high::before { content: "\f1ce"; }
+.bi-brightness-alt-low-fill::before { content: "\f1cf"; }
+.bi-brightness-alt-low::before { content: "\f1d0"; }
+.bi-brightness-high-fill::before { content: "\f1d1"; }
+.bi-brightness-high::before { content: "\f1d2"; }
+.bi-brightness-low-fill::before { content: "\f1d3"; }
+.bi-brightness-low::before { content: "\f1d4"; }
+.bi-broadcast-pin::before { content: "\f1d5"; }
+.bi-broadcast::before { content: "\f1d6"; }
+.bi-brush-fill::before { content: "\f1d7"; }
+.bi-brush::before { content: "\f1d8"; }
+.bi-bucket-fill::before { content: "\f1d9"; }
+.bi-bucket::before { content: "\f1da"; }
+.bi-bug-fill::before { content: "\f1db"; }
+.bi-bug::before { content: "\f1dc"; }
+.bi-building::before { content: "\f1dd"; }
+.bi-bullseye::before { content: "\f1de"; }
+.bi-calculator-fill::before { content: "\f1df"; }
+.bi-calculator::before { content: "\f1e0"; }
+.bi-calendar-check-fill::before { content: "\f1e1"; }
+.bi-calendar-check::before { content: "\f1e2"; }
+.bi-calendar-date-fill::before { content: "\f1e3"; }
+.bi-calendar-date::before { content: "\f1e4"; }
+.bi-calendar-day-fill::before { content: "\f1e5"; }
+.bi-calendar-day::before { content: "\f1e6"; }
+.bi-calendar-event-fill::before { content: "\f1e7"; }
+.bi-calendar-event::before { content: "\f1e8"; }
+.bi-calendar-fill::before { content: "\f1e9"; }
+.bi-calendar-minus-fill::before { content: "\f1ea"; }
+.bi-calendar-minus::before { content: "\f1eb"; }
+.bi-calendar-month-fill::before { content: "\f1ec"; }
+.bi-calendar-month::before { content: "\f1ed"; }
+.bi-calendar-plus-fill::before { content: "\f1ee"; }
+.bi-calendar-plus::before { content: "\f1ef"; }
+.bi-calendar-range-fill::before { content: "\f1f0"; }
+.bi-calendar-range::before { content: "\f1f1"; }
+.bi-calendar-week-fill::before { content: "\f1f2"; }
+.bi-calendar-week::before { content: "\f1f3"; }
+.bi-calendar-x-fill::before { content: "\f1f4"; }
+.bi-calendar-x::before { content: "\f1f5"; }
+.bi-calendar::before { content: "\f1f6"; }
+.bi-calendar2-check-fill::before { content: "\f1f7"; }
+.bi-calendar2-check::before { content: "\f1f8"; }
+.bi-calendar2-date-fill::before { content: "\f1f9"; }
+.bi-calendar2-date::before { content: "\f1fa"; }
+.bi-calendar2-day-fill::before { content: "\f1fb"; }
+.bi-calendar2-day::before { content: "\f1fc"; }
+.bi-calendar2-event-fill::before { content: "\f1fd"; }
+.bi-calendar2-event::before { content: "\f1fe"; }
+.bi-calendar2-fill::before { content: "\f1ff"; }
+.bi-calendar2-minus-fill::before { content: "\f200"; }
+.bi-calendar2-minus::before { content: "\f201"; }
+.bi-calendar2-month-fill::before { content: "\f202"; }
+.bi-calendar2-month::before { content: "\f203"; }
+.bi-calendar2-plus-fill::before { content: "\f204"; }
+.bi-calendar2-plus::before { content: "\f205"; }
+.bi-calendar2-range-fill::before { content: "\f206"; }
+.bi-calendar2-range::before { content: "\f207"; }
+.bi-calendar2-week-fill::before { content: "\f208"; }
+.bi-calendar2-week::before { content: "\f209"; }
+.bi-calendar2-x-fill::before { content: "\f20a"; }
+.bi-calendar2-x::before { content: "\f20b"; }
+.bi-calendar2::before { content: "\f20c"; }
+.bi-calendar3-event-fill::before { content: "\f20d"; }
+.bi-calendar3-event::before { content: "\f20e"; }
+.bi-calendar3-fill::before { content: "\f20f"; }
+.bi-calendar3-range-fill::before { content: "\f210"; }
+.bi-calendar3-range::before { content: "\f211"; }
+.bi-calendar3-week-fill::before { content: "\f212"; }
+.bi-calendar3-week::before { content: "\f213"; }
+.bi-calendar3::before { content: "\f214"; }
+.bi-calendar4-event::before { content: "\f215"; }
+.bi-calendar4-range::before { content: "\f216"; }
+.bi-calendar4-week::before { content: "\f217"; }
+.bi-calendar4::before { content: "\f218"; }
+.bi-camera-fill::before { content: "\f219"; }
+.bi-camera-reels-fill::before { content: "\f21a"; }
+.bi-camera-reels::before { content: "\f21b"; }
+.bi-camera-video-fill::before { content: "\f21c"; }
+.bi-camera-video-off-fill::before { content: "\f21d"; }
+.bi-camera-video-off::before { content: "\f21e"; }
+.bi-camera-video::before { content: "\f21f"; }
+.bi-camera::before { content: "\f220"; }
+.bi-camera2::before { content: "\f221"; }
+.bi-capslock-fill::before { content: "\f222"; }
+.bi-capslock::before { content: "\f223"; }
+.bi-card-checklist::before { content: "\f224"; }
+.bi-card-heading::before { content: "\f225"; }
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+.bi-person-exclamation::before { content: "\f89c"; }
+.bi-person-fill-add::before { content: "\f89d"; }
+.bi-person-fill-check::before { content: "\f89e"; }
+.bi-person-fill-dash::before { content: "\f89f"; }
+.bi-person-fill-down::before { content: "\f8a0"; }
+.bi-person-fill-exclamation::before { content: "\f8a1"; }
+.bi-person-fill-gear::before { content: "\f8a2"; }
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+.bi-person-fill-x::before { content: "\f8a6"; }
+.bi-person-gear::before { content: "\f8a7"; }
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+.bi-taxi-front::before { content: "\f8ad"; }
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+.bi-database-fill-add::before { content: "\f8b4"; }
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+.bi-database-fill-dash::before { content: "\f8b6"; }
+.bi-database-fill-down::before { content: "\f8b7"; }
+.bi-database-fill-exclamation::before { content: "\f8b8"; }
+.bi-database-fill-gear::before { content: "\f8b9"; }
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+.bi-database-gear::before { content: "\f8bf"; }
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+.bi-database-slash::before { content: "\f8c1"; }
+.bi-database-up::before { content: "\f8c2"; }
+.bi-database-x::before { content: "\f8c3"; }
+.bi-database::before { content: "\f8c4"; }
+.bi-houses-fill::before { content: "\f8c5"; }
+.bi-houses::before { content: "\f8c6"; }
+.bi-nvidia::before { content: "\f8c7"; }
+.bi-person-vcard-fill::before { content: "\f8c8"; }
+.bi-person-vcard::before { content: "\f8c9"; }
+.bi-sina-weibo::before { content: "\f8ca"; }
+.bi-tencent-qq::before { content: "\f8cb"; }
+.bi-wikipedia::before { content: "\f8cc"; }
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diff --git a/stable/site_libs/bootstrap/bootstrap.min.css b/stable/site_libs/bootstrap/bootstrap.min.css
new file mode 100644
index 0000000000..62826f72de
--- /dev/null
+++ b/stable/site_libs/bootstrap/bootstrap.min.css
@@ -0,0 +1,10 @@
+/*!
+ * Bootstrap v5.1.3 (https://getbootstrap.com/)
+ * Copyright 2011-2021 The Bootstrap Authors
+ * Copyright 2011-2021 Twitter, Inc.
+ * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
+ */@import"https://fonts.googleapis.com/css2?family=Lato:ital,wght@0,400;0,700;1,400&display=swap";:root{--bs-blue: #2c3e50;--bs-indigo: #6610f2;--bs-purple: #6f42c1;--bs-pink: #e83e8c;--bs-red: #e74c3c;--bs-orange: #fd7e14;--bs-yellow: #f39c12;--bs-green: #18bc9c;--bs-teal: #20c997;--bs-cyan: #3498db;--bs-white: #fff;--bs-gray: #6c757d;--bs-gray-dark: #343a40;--bs-gray-100: #f8f9fa;--bs-gray-200: #ecf0f1;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #adb5bd;--bs-gray-600: #6c757d;--bs-gray-700: #7b8a8b;--bs-gray-800: #343a40;--bs-gray-900: #212529;--bs-default: #6c757d;--bs-primary: #2c3e50;--bs-secondary: #6c757d;--bs-success: #18bc9c;--bs-info: #3498db;--bs-warning: #f39c12;--bs-danger: #e74c3c;--bs-light: #ecf0f1;--bs-dark: #7b8a8b;--bs-default-rgb: 108, 117, 125;--bs-primary-rgb: 44, 62, 80;--bs-secondary-rgb: 108, 117, 125;--bs-success-rgb: 24, 188, 156;--bs-info-rgb: 52, 152, 219;--bs-warning-rgb: 243, 156, 18;--bs-danger-rgb: 231, 76, 60;--bs-light-rgb: 236, 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e=t.getBoundingClientRect();return{top:e.top+window.pageYOffset,left:e.left+window.pageXOffset}},position:t=>({top:t.offsetTop,left:t.offsetLeft})},V={find:(t,e=document.documentElement)=>[].concat(...Element.prototype.querySelectorAll.call(e,t)),findOne:(t,e=document.documentElement)=>Element.prototype.querySelector.call(e,t),children:(t,e)=>[].concat(...t.children).filter((t=>t.matches(e))),parents(t,e){const i=[];let n=t.parentNode;for(;n&&n.nodeType===Node.ELEMENT_NODE&&3!==n.nodeType;)n.matches(e)&&i.push(n),n=n.parentNode;return i},prev(t,e){let i=t.previousElementSibling;for(;i;){if(i.matches(e))return[i];i=i.previousElementSibling}return[]},next(t,e){let i=t.nextElementSibling;for(;i;){if(i.matches(e))return[i];i=i.nextElementSibling}return[]},focusableChildren(t){const e=["a","button","input","textarea","select","details","[tabindex]",'[contenteditable="true"]'].map((t=>`${t}:not([tabindex^="-"])`)).join(", ");return this.find(e,t).filter((t=>!c(t)&&l(t)))}},K="carousel",X={interval:5e3,keyboard:!0,slide:!1,pause:"hover",wrap:!0,touch:!0},Y={interval:"(number|boolean)",keyboard:"boolean",slide:"(boolean|string)",pause:"(string|boolean)",wrap:"boolean",touch:"boolean"},Q="next",G="prev",Z="left",J="right",tt={ArrowLeft:J,ArrowRight:Z},et="slid.bs.carousel",it="active",nt=".active.carousel-item";class st extends B{constructor(t,e){super(t),this._items=null,this._interval=null,this._activeElement=null,this._isPaused=!1,this._isSliding=!1,this.touchTimeout=null,this.touchStartX=0,this.touchDeltaX=0,this._config=this._getConfig(e),this._indicatorsElement=V.findOne(".carousel-indicators",this._element),this._touchSupported="ontouchstart"in document.documentElement||navigator.maxTouchPoints>0,this._pointerEvent=Boolean(window.PointerEvent),this._addEventListeners()}static get Default(){return X}static get NAME(){return K}next(){this._slide(Q)}nextWhenVisible(){!document.hidden&&l(this._element)&&this.next()}prev(){this._slide(G)}pause(t){t||(this._isPaused=!0),V.findOne(".carousel-item-next, .carousel-item-prev",this._element)&&(s(this._element),this.cycle(!0)),clearInterval(this._interval),this._interval=null}cycle(t){t||(this._isPaused=!1),this._interval&&(clearInterval(this._interval),this._interval=null),this._config&&this._config.interval&&!this._isPaused&&(this._updateInterval(),this._interval=setInterval((document.visibilityState?this.nextWhenVisible:this.next).bind(this),this._config.interval))}to(t){this._activeElement=V.findOne(nt,this._element);const e=this._getItemIndex(this._activeElement);if(t>this._items.length-1||t<0)return;if(this._isSliding)return void j.one(this._element,et,(()=>this.to(t)));if(e===t)return this.pause(),void this.cycle();const i=t>e?Q:G;this._slide(i,this._items[t])}_getConfig(t){return t={...X,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(K,t,Y),t}_handleSwipe(){const t=Math.abs(this.touchDeltaX);if(t<=40)return;const e=t/this.touchDeltaX;this.touchDeltaX=0,e&&this._slide(e>0?J:Z)}_addEventListeners(){this._config.keyboard&&j.on(this._element,"keydown.bs.carousel",(t=>this._keydown(t))),"hover"===this._config.pause&&(j.on(this._element,"mouseenter.bs.carousel",(t=>this.pause(t))),j.on(this._element,"mouseleave.bs.carousel",(t=>this.cycle(t)))),this._config.touch&&this._touchSupported&&this._addTouchEventListeners()}_addTouchEventListeners(){const t=t=>this._pointerEvent&&("pen"===t.pointerType||"touch"===t.pointerType),e=e=>{t(e)?this.touchStartX=e.clientX:this._pointerEvent||(this.touchStartX=e.touches[0].clientX)},i=t=>{this.touchDeltaX=t.touches&&t.touches.length>1?0:t.touches[0].clientX-this.touchStartX},n=e=>{t(e)&&(this.touchDeltaX=e.clientX-this.touchStartX),this._handleSwipe(),"hover"===this._config.pause&&(this.pause(),this.touchTimeout&&clearTimeout(this.touchTimeout),this.touchTimeout=setTimeout((t=>this.cycle(t)),500+this._config.interval))};V.find(".carousel-item img",this._element).forEach((t=>{j.on(t,"dragstart.bs.carousel",(t=>t.preventDefault()))})),this._pointerEvent?(j.on(this._element,"pointerdown.bs.carousel",(t=>e(t))),j.on(this._element,"pointerup.bs.carousel",(t=>n(t))),this._element.classList.add("pointer-event")):(j.on(this._element,"touchstart.bs.carousel",(t=>e(t))),j.on(this._element,"touchmove.bs.carousel",(t=>i(t))),j.on(this._element,"touchend.bs.carousel",(t=>n(t))))}_keydown(t){if(/input|textarea/i.test(t.target.tagName))return;const e=tt[t.key];e&&(t.preventDefault(),this._slide(e))}_getItemIndex(t){return this._items=t&&t.parentNode?V.find(".carousel-item",t.parentNode):[],this._items.indexOf(t)}_getItemByOrder(t,e){const i=t===Q;return v(this._items,e,i,this._config.wrap)}_triggerSlideEvent(t,e){const i=this._getItemIndex(t),n=this._getItemIndex(V.findOne(nt,this._element));return j.trigger(this._element,"slide.bs.carousel",{relatedTarget:t,direction:e,from:n,to:i})}_setActiveIndicatorElement(t){if(this._indicatorsElement){const e=V.findOne(".active",this._indicatorsElement);e.classList.remove(it),e.removeAttribute("aria-current");const i=V.find("[data-bs-target]",this._indicatorsElement);for(let e=0;e<i.length;e++)if(Number.parseInt(i[e].getAttribute("data-bs-slide-to"),10)===this._getItemIndex(t)){i[e].classList.add(it),i[e].setAttribute("aria-current","true");break}}}_updateInterval(){const t=this._activeElement||V.findOne(nt,this._element);if(!t)return;const e=Number.parseInt(t.getAttribute("data-bs-interval"),10);e?(this._config.defaultInterval=this._config.defaultInterval||this._config.interval,this._config.interval=e):this._config.interval=this._config.defaultInterval||this._config.interval}_slide(t,e){const i=this._directionToOrder(t),n=V.findOne(nt,this._element),s=this._getItemIndex(n),o=e||this._getItemByOrder(i,n),r=this._getItemIndex(o),a=Boolean(this._interval),l=i===Q,c=l?"carousel-item-start":"carousel-item-end",h=l?"carousel-item-next":"carousel-item-prev",d=this._orderToDirection(i);if(o&&o.classList.contains(it))return void(this._isSliding=!1);if(this._isSliding)return;if(this._triggerSlideEvent(o,d).defaultPrevented)return;if(!n||!o)return;this._isSliding=!0,a&&this.pause(),this._setActiveIndicatorElement(o),this._activeElement=o;const f=()=>{j.trigger(this._element,et,{relatedTarget:o,direction:d,from:s,to:r})};if(this._element.classList.contains("slide")){o.classList.add(h),u(o),n.classList.add(c),o.classList.add(c);const t=()=>{o.classList.remove(c,h),o.classList.add(it),n.classList.remove(it,h,c),this._isSliding=!1,setTimeout(f,0)};this._queueCallback(t,n,!0)}else n.classList.remove(it),o.classList.add(it),this._isSliding=!1,f();a&&this.cycle()}_directionToOrder(t){return[J,Z].includes(t)?m()?t===Z?G:Q:t===Z?Q:G:t}_orderToDirection(t){return[Q,G].includes(t)?m()?t===G?Z:J:t===G?J:Z:t}static carouselInterface(t,e){const i=st.getOrCreateInstance(t,e);let{_config:n}=i;"object"==typeof e&&(n={...n,...e});const s="string"==typeof e?e:n.slide;if("number"==typeof e)i.to(e);else if("string"==typeof s){if(void 0===i[s])throw new TypeError(`No method named "${s}"`);i[s]()}else n.interval&&n.ride&&(i.pause(),i.cycle())}static jQueryInterface(t){return this.each((function(){st.carouselInterface(this,t)}))}static dataApiClickHandler(t){const e=n(this);if(!e||!e.classList.contains("carousel"))return;const i={...U.getDataAttributes(e),...U.getDataAttributes(this)},s=this.getAttribute("data-bs-slide-to");s&&(i.interval=!1),st.carouselInterface(e,i),s&&st.getInstance(e).to(s),t.preventDefault()}}j.on(document,"click.bs.carousel.data-api","[data-bs-slide], [data-bs-slide-to]",st.dataApiClickHandler),j.on(window,"load.bs.carousel.data-api",(()=>{const t=V.find('[data-bs-ride="carousel"]');for(let e=0,i=t.length;e<i;e++)st.carouselInterface(t[e],st.getInstance(t[e]))})),g(st);const ot="collapse",rt={toggle:!0,parent:null},at={toggle:"boolean",parent:"(null|element)"},lt="show",ct="collapse",ht="collapsing",dt="collapsed",ut=":scope .collapse .collapse",ft='[data-bs-toggle="collapse"]';class pt extends B{constructor(t,e){super(t),this._isTransitioning=!1,this._config=this._getConfig(e),this._triggerArray=[];const n=V.find(ft);for(let t=0,e=n.length;t<e;t++){const e=n[t],s=i(e),o=V.find(s).filter((t=>t===this._element));null!==s&&o.length&&(this._selector=s,this._triggerArray.push(e))}this._initializeChildren(),this._config.parent||this._addAriaAndCollapsedClass(this._triggerArray,this._isShown()),this._config.toggle&&this.toggle()}static get Default(){return rt}static get NAME(){return ot}toggle(){this._isShown()?this.hide():this.show()}show(){if(this._isTransitioning||this._isShown())return;let t,e=[];if(this._config.parent){const t=V.find(ut,this._config.parent);e=V.find(".collapse.show, .collapse.collapsing",this._config.parent).filter((e=>!t.includes(e)))}const i=V.findOne(this._selector);if(e.length){const n=e.find((t=>i!==t));if(t=n?pt.getInstance(n):null,t&&t._isTransitioning)return}if(j.trigger(this._element,"show.bs.collapse").defaultPrevented)return;e.forEach((e=>{i!==e&&pt.getOrCreateInstance(e,{toggle:!1}).hide(),t||H.set(e,"bs.collapse",null)}));const n=this._getDimension();this._element.classList.remove(ct),this._element.classList.add(ht),this._element.style[n]=0,this._addAriaAndCollapsedClass(this._triggerArray,!0),this._isTransitioning=!0;const s=`scroll${n[0].toUpperCase()+n.slice(1)}`;this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(ht),this._element.classList.add(ct,lt),this._element.style[n]="",j.trigger(this._element,"shown.bs.collapse")}),this._element,!0),this._element.style[n]=`${this._element[s]}px`}hide(){if(this._isTransitioning||!this._isShown())return;if(j.trigger(this._element,"hide.bs.collapse").defaultPrevented)return;const t=this._getDimension();this._element.style[t]=`${this._element.getBoundingClientRect()[t]}px`,u(this._element),this._element.classList.add(ht),this._element.classList.remove(ct,lt);const e=this._triggerArray.length;for(let t=0;t<e;t++){const e=this._triggerArray[t],i=n(e);i&&!this._isShown(i)&&this._addAriaAndCollapsedClass([e],!1)}this._isTransitioning=!0,this._element.style[t]="",this._queueCallback((()=>{this._isTransitioning=!1,this._element.classList.remove(ht),this._element.classList.add(ct),j.trigger(this._element,"hidden.bs.collapse")}),this._element,!0)}_isShown(t=this._element){return t.classList.contains(lt)}_getConfig(t){return(t={...rt,...U.getDataAttributes(this._element),...t}).toggle=Boolean(t.toggle),t.parent=r(t.parent),a(ot,t,at),t}_getDimension(){return this._element.classList.contains("collapse-horizontal")?"width":"height"}_initializeChildren(){if(!this._config.parent)return;const t=V.find(ut,this._config.parent);V.find(ft,this._config.parent).filter((e=>!t.includes(e))).forEach((t=>{const e=n(t);e&&this._addAriaAndCollapsedClass([t],this._isShown(e))}))}_addAriaAndCollapsedClass(t,e){t.length&&t.forEach((t=>{e?t.classList.remove(dt):t.classList.add(dt),t.setAttribute("aria-expanded",e)}))}static jQueryInterface(t){return this.each((function(){const e={};"string"==typeof t&&/show|hide/.test(t)&&(e.toggle=!1);const i=pt.getOrCreateInstance(this,e);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t]()}}))}}j.on(document,"click.bs.collapse.data-api",ft,(function(t){("A"===t.target.tagName||t.delegateTarget&&"A"===t.delegateTarget.tagName)&&t.preventDefault();const e=i(this);V.find(e).forEach((t=>{pt.getOrCreateInstance(t,{toggle:!1}).toggle()}))})),g(pt);var mt="top",gt="bottom",_t="right",bt="left",vt="auto",yt=[mt,gt,_t,bt],wt="start",Et="end",At="clippingParents",Tt="viewport",Ot="popper",Ct="reference",kt=yt.reduce((function(t,e){return t.concat([e+"-"+wt,e+"-"+Et])}),[]),Lt=[].concat(yt,[vt]).reduce((function(t,e){return t.concat([e,e+"-"+wt,e+"-"+Et])}),[]),xt="beforeRead",Dt="read",St="afterRead",Nt="beforeMain",It="main",Pt="afterMain",jt="beforeWrite",Mt="write",Ht="afterWrite",Bt=[xt,Dt,St,Nt,It,Pt,jt,Mt,Ht];function Rt(t){return t?(t.nodeName||"").toLowerCase():null}function Wt(t){if(null==t)return window;if("[object Window]"!==t.toString()){var e=t.ownerDocument;return e&&e.defaultView||window}return t}function $t(t){return t instanceof Wt(t).Element||t instanceof Element}function zt(t){return t instanceof Wt(t).HTMLElement||t instanceof HTMLElement}function qt(t){return"undefined"!=typeof ShadowRoot&&(t instanceof Wt(t).ShadowRoot||t instanceof ShadowRoot)}const Ft={name:"applyStyles",enabled:!0,phase:"write",fn:function(t){var e=t.state;Object.keys(e.elements).forEach((function(t){var i=e.styles[t]||{},n=e.attributes[t]||{},s=e.elements[t];zt(s)&&Rt(s)&&(Object.assign(s.style,i),Object.keys(n).forEach((function(t){var e=n[t];!1===e?s.removeAttribute(t):s.setAttribute(t,!0===e?"":e)})))}))},effect:function(t){var e=t.state,i={popper:{position:e.options.strategy,left:"0",top:"0",margin:"0"},arrow:{position:"absolute"},reference:{}};return Object.assign(e.elements.popper.style,i.popper),e.styles=i,e.elements.arrow&&Object.assign(e.elements.arrow.style,i.arrow),function(){Object.keys(e.elements).forEach((function(t){var n=e.elements[t],s=e.attributes[t]||{},o=Object.keys(e.styles.hasOwnProperty(t)?e.styles[t]:i[t]).reduce((function(t,e){return t[e]="",t}),{});zt(n)&&Rt(n)&&(Object.assign(n.style,o),Object.keys(s).forEach((function(t){n.removeAttribute(t)})))}))}},requires:["computeStyles"]};function Ut(t){return t.split("-")[0]}function Vt(t,e){var i=t.getBoundingClientRect();return{width:i.width/1,height:i.height/1,top:i.top/1,right:i.right/1,bottom:i.bottom/1,left:i.left/1,x:i.left/1,y:i.top/1}}function Kt(t){var e=Vt(t),i=t.offsetWidth,n=t.offsetHeight;return Math.abs(e.width-i)<=1&&(i=e.width),Math.abs(e.height-n)<=1&&(n=e.height),{x:t.offsetLeft,y:t.offsetTop,width:i,height:n}}function Xt(t,e){var i=e.getRootNode&&e.getRootNode();if(t.contains(e))return!0;if(i&&qt(i)){var 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Be={placement:"bottom",modifiers:[],strategy:"absolute"};function Re(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function We(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?Be:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},Be,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof i?i(a.options):i;d(),a.options=Object.assign({},o,a.options,s),a.scrollParents={reference:$t(t)?Ae(t):t.contextElement?Ae(t.contextElement):[],popper:Ae(e)};var r,c,u=function(t){var e=He(t);return Bt.reduce((function(t,i){return t.concat(e.filter((function(t){return t.phase===i})))}),[])}((r=[].concat(n,a.options.modifiers),c=r.reduce((function(t,e){var i=t[e.name];return 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this._isShown()?this.hide():this.show()}show(){if(c(this._element)||this._isShown(this._menu))return;const t={relatedTarget:this._element};if(j.trigger(this._element,"show.bs.dropdown",t).defaultPrevented)return;const e=hi.getParentFromElement(this._element);this._inNavbar?U.setDataAttribute(this._menu,"popper","none"):this._createPopper(e),"ontouchstart"in document.documentElement&&!e.closest(".navbar-nav")&&[].concat(...document.body.children).forEach((t=>j.on(t,"mouseover",d))),this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add(Je),this._element.classList.add(Je),j.trigger(this._element,"shown.bs.dropdown",t)}hide(){if(c(this._element)||!this._isShown(this._menu))return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){j.trigger(this._element,"hide.bs.dropdown",t).defaultPrevented||("ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._popper&&this._popper.destroy(),this._menu.classList.remove(Je),this._element.classList.remove(Je),this._element.setAttribute("aria-expanded","false"),U.removeDataAttribute(this._menu,"popper"),j.trigger(this._element,"hidden.bs.dropdown",t))}_getConfig(t){if(t={...this.constructor.Default,...U.getDataAttributes(this._element),...t},a(Ue,t,this.constructor.DefaultType),"object"==typeof t.reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${Ue.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(t){if(void 0===Fe)throw new TypeError("Bootstrap's dropdowns require Popper (https://popper.js.org)");let e=this._element;"parent"===this._config.reference?e=t:o(this._config.reference)?e=r(this._config.reference):"object"==typeof this._config.reference&&(e=this._config.reference);const i=this._getPopperConfig(),n=i.modifiers.find((t=>"applyStyles"===t.name&&!1===t.enabled));this._popper=qe(e,this._menu,i),n&&U.setDataAttribute(this._menu,"popper","static")}_isShown(t=this._element){return t.classList.contains(Je)}_getMenuElement(){return V.next(this._element,ei)[0]}_getPlacement(){const t=this._element.parentNode;if(t.classList.contains("dropend"))return ri;if(t.classList.contains("dropstart"))return ai;const e="end"===getComputedStyle(this._menu).getPropertyValue("--bs-position").trim();return t.classList.contains("dropup")?e?ni:ii:e?oi:si}_detectNavbar(){return null!==this._element.closest(".navbar")}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return"static"===this._config.display&&(t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=V.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter(l);i.length&&v(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(t&&(2===t.button||"keyup"===t.type&&"Tab"!==t.key))return;const e=V.find(ti);for(let i=0,n=e.length;i<n;i++){const n=hi.getInstance(e[i]);if(!n||!1===n._config.autoClose)continue;if(!n._isShown())continue;const s={relatedTarget:n._element};if(t){const e=t.composedPath(),i=e.includes(n._menu);if(e.includes(n._element)||"inside"===n._config.autoClose&&!i||"outside"===n._config.autoClose&&i)continue;if(n._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;"click"===t.type&&(s.clickEvent=t)}n._completeHide(s)}}static getParentFromElement(t){return n(t)||t.parentNode}static dataApiKeydownHandler(t){if(/input|textarea/i.test(t.target.tagName)?t.key===Ke||t.key!==Ve&&(t.key!==Ye&&t.key!==Xe||t.target.closest(ei)):!Qe.test(t.key))return;const e=this.classList.contains(Je);if(!e&&t.key===Ve)return;if(t.preventDefault(),t.stopPropagation(),c(this))return;const i=this.matches(ti)?this:V.prev(this,ti)[0],n=hi.getOrCreateInstance(i);if(t.key!==Ve)return t.key===Xe||t.key===Ye?(e||n.show(),void n._selectMenuItem(t)):void(e&&t.key!==Ke||hi.clearMenus());n.hide()}}j.on(document,Ze,ti,hi.dataApiKeydownHandler),j.on(document,Ze,ei,hi.dataApiKeydownHandler),j.on(document,Ge,hi.clearMenus),j.on(document,"keyup.bs.dropdown.data-api",hi.clearMenus),j.on(document,Ge,ti,(function(t){t.preventDefault(),hi.getOrCreateInstance(this).toggle()})),g(hi);const di=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",ui=".sticky-top";class fi{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,"paddingRight",(e=>e+t)),this._setElementAttributes(di,"paddingRight",(e=>e+t)),this._setElementAttributes(ui,"marginRight",(e=>e-t))}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t)[e];t.style[e]=`${i(Number.parseFloat(s))}px`}))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,"paddingRight"),this._resetElementAttributes(di,"paddingRight"),this._resetElementAttributes(ui,"marginRight")}_saveInitialAttribute(t,e){const i=t.style[e];i&&U.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=U.getDataAttribute(t,e);void 0===i?t.style.removeProperty(e):(U.removeDataAttribute(t,e),t.style[e]=i)}))}_applyManipulationCallback(t,e){o(t)?e(t):V.find(t,this._element).forEach(e)}isOverflowing(){return this.getWidth()>0}}const pi={className:"modal-backdrop",isVisible:!0,isAnimated:!1,rootElement:"body",clickCallback:null},mi={className:"string",isVisible:"boolean",isAnimated:"boolean",rootElement:"(element|string)",clickCallback:"(function|null)"},gi="show",_i="mousedown.bs.backdrop";class bi{constructor(t){this._config=this._getConfig(t),this._isAppended=!1,this._element=null}show(t){this._config.isVisible?(this._append(),this._config.isAnimated&&u(this._getElement()),this._getElement().classList.add(gi),this._emulateAnimation((()=>{_(t)}))):_(t)}hide(t){this._config.isVisible?(this._getElement().classList.remove(gi),this._emulateAnimation((()=>{this.dispose(),_(t)}))):_(t)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_getConfig(t){return(t={...pi,..."object"==typeof t?t:{}}).rootElement=r(t.rootElement),a("backdrop",t,mi),t}_append(){this._isAppended||(this._config.rootElement.append(this._getElement()),j.on(this._getElement(),_i,(()=>{_(this._config.clickCallback)})),this._isAppended=!0)}dispose(){this._isAppended&&(j.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_emulateAnimation(t){b(t,this._getElement(),this._config.isAnimated)}}const vi={trapElement:null,autofocus:!0},yi={trapElement:"element",autofocus:"boolean"},wi=".bs.focustrap",Ei="backward";class Ai{constructor(t){this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}activate(){const{trapElement:t,autofocus:e}=this._config;this._isActive||(e&&t.focus(),j.off(document,wi),j.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),j.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,j.off(document,wi))}_handleFocusin(t){const{target:e}=t,{trapElement:i}=this._config;if(e===document||e===i||i.contains(e))return;const n=V.focusableChildren(i);0===n.length?i.focus():this._lastTabNavDirection===Ei?n[n.length-1].focus():n[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ei:"forward")}_getConfig(t){return t={...vi,..."object"==typeof t?t:{}},a("focustrap",t,yi),t}}const Ti="modal",Oi="Escape",Ci={backdrop:!0,keyboard:!0,focus:!0},ki={backdrop:"(boolean|string)",keyboard:"boolean",focus:"boolean"},Li="hidden.bs.modal",xi="show.bs.modal",Di="resize.bs.modal",Si="click.dismiss.bs.modal",Ni="keydown.dismiss.bs.modal",Ii="mousedown.dismiss.bs.modal",Pi="modal-open",ji="show",Mi="modal-static";class Hi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._dialog=V.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._ignoreBackdropClick=!1,this._isTransitioning=!1,this._scrollBar=new fi}static get Default(){return Ci}static get NAME(){return Ti}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||j.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isAnimated()&&(this._isTransitioning=!0),this._scrollBar.hide(),document.body.classList.add(Pi),this._adjustDialog(),this._setEscapeEvent(),this._setResizeEvent(),j.on(this._dialog,Ii,(()=>{j.one(this._element,"mouseup.dismiss.bs.modal",(t=>{t.target===this._element&&(this._ignoreBackdropClick=!0)}))})),this._showBackdrop((()=>this._showElement(t))))}hide(){if(!this._isShown||this._isTransitioning)return;if(j.trigger(this._element,"hide.bs.modal").defaultPrevented)return;this._isShown=!1;const t=this._isAnimated();t&&(this._isTransitioning=!0),this._setEscapeEvent(),this._setResizeEvent(),this._focustrap.deactivate(),this._element.classList.remove(ji),j.off(this._element,Si),j.off(this._dialog,Ii),this._queueCallback((()=>this._hideModal()),this._element,t)}dispose(){[window,this._dialog].forEach((t=>j.off(t,".bs.modal"))),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new bi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_getConfig(t){return t={...Ci,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Ti,t,ki),t}_showElement(t){const e=this._isAnimated(),i=V.findOne(".modal-body",this._dialog);this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0,i&&(i.scrollTop=0),e&&u(this._element),this._element.classList.add(ji),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,j.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,e)}_setEscapeEvent(){this._isShown?j.on(this._element,Ni,(t=>{this._config.keyboard&&t.key===Oi?(t.preventDefault(),this.hide()):this._config.keyboard||t.key!==Oi||this._triggerBackdropTransition()})):j.off(this._element,Ni)}_setResizeEvent(){this._isShown?j.on(window,Di,(()=>this._adjustDialog())):j.off(window,Di)}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(Pi),this._resetAdjustments(),this._scrollBar.reset(),j.trigger(this._element,Li)}))}_showBackdrop(t){j.on(this._element,Si,(t=>{this._ignoreBackdropClick?this._ignoreBackdropClick=!1:t.target===t.currentTarget&&(!0===this._config.backdrop?this.hide():"static"===this._config.backdrop&&this._triggerBackdropTransition())})),this._backdrop.show(t)}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(j.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const{classList:t,scrollHeight:e,style:i}=this._element,n=e>document.documentElement.clientHeight;!n&&"hidden"===i.overflowY||t.contains(Mi)||(n||(i.overflowY="hidden"),t.add(Mi),this._queueCallback((()=>{t.remove(Mi),n||this._queueCallback((()=>{i.overflowY=""}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;(!i&&t&&!m()||i&&!t&&m())&&(this._element.style.paddingLeft=`${e}px`),(i&&!t&&!m()||!i&&t&&m())&&(this._element.style.paddingRight=`${e}px`)}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}j.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),j.one(e,xi,(t=>{t.defaultPrevented||j.one(e,Li,(()=>{l(this)&&this.focus()}))}));const i=V.findOne(".modal.show");i&&Hi.getInstance(i).hide(),Hi.getOrCreateInstance(e).toggle(this)})),R(Hi),g(Hi);const Bi="offcanvas",Ri={backdrop:!0,keyboard:!0,scroll:!1},Wi={backdrop:"boolean",keyboard:"boolean",scroll:"boolean"},$i="show",zi=".offcanvas.show",qi="hidden.bs.offcanvas";class Fi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get NAME(){return Bi}static get Default(){return Ri}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||j.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._element.style.visibility="visible",this._backdrop.show(),this._config.scroll||(new fi).hide(),this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add($i),this._queueCallback((()=>{this._config.scroll||this._focustrap.activate(),j.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(j.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.remove($i),this._backdrop.hide(),this._queueCallback((()=>{this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._element.style.visibility="hidden",this._config.scroll||(new fi).reset(),j.trigger(this._element,qi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_getConfig(t){return t={...Ri,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Bi,t,Wi),t}_initializeBackDrop(){return new bi({className:"offcanvas-backdrop",isVisible:this._config.backdrop,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:()=>this.hide()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_addEventListeners(){j.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{this._config.keyboard&&"Escape"===t.key&&this.hide()}))}static jQueryInterface(t){return this.each((function(){const e=Fi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}j.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this))return;j.one(e,qi,(()=>{l(this)&&this.focus()}));const i=V.findOne(zi);i&&i!==e&&Fi.getInstance(i).hide(),Fi.getOrCreateInstance(e).toggle(this)})),j.on(window,"load.bs.offcanvas.data-api",(()=>V.find(zi).forEach((t=>Fi.getOrCreateInstance(t).show())))),R(Fi),g(Fi);const Ui=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Vi=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Ki=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Xi=(t,e)=>{const i=t.nodeName.toLowerCase();if(e.includes(i))return!Ui.has(i)||Boolean(Vi.test(t.nodeValue)||Ki.test(t.nodeValue));const n=e.filter((t=>t instanceof RegExp));for(let t=0,e=n.length;t<e;t++)if(n[t].test(i))return!0;return!1};function Yi(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(let t=0,i=s.length;t<i;t++){const i=s[t],n=i.nodeName.toLowerCase();if(!Object.keys(e).includes(n)){i.remove();continue}const o=[].concat(...i.attributes),r=[].concat(e["*"]||[],e[n]||[]);o.forEach((t=>{Xi(t,r)||i.removeAttribute(t.nodeName)}))}return n.body.innerHTML}const Qi="tooltip",Gi=new Set(["sanitize","allowList","sanitizeFn"]),Zi={animation:"boolean",template:"string",title:"(string|element|function)",trigger:"string",delay:"(number|object)",html:"boolean",selector:"(string|boolean)",placement:"(string|function)",offset:"(array|string|function)",container:"(string|element|boolean)",fallbackPlacements:"array",boundary:"(string|element)",customClass:"(string|function)",sanitize:"boolean",sanitizeFn:"(null|function)",allowList:"object",popperConfig:"(null|object|function)"},Ji={AUTO:"auto",TOP:"top",RIGHT:m()?"left":"right",BOTTOM:"bottom",LEFT:m()?"right":"left"},tn={animation:!0,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',trigger:"hover focus",title:"",delay:0,html:!1,selector:!1,placement:"top",offset:[0,0],container:!1,fallbackPlacements:["top","right","bottom","left"],boundary:"clippingParents",customClass:"",sanitize:!0,sanitizeFn:null,allowList:{"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},popperConfig:null},en={HIDE:"hide.bs.tooltip",HIDDEN:"hidden.bs.tooltip",SHOW:"show.bs.tooltip",SHOWN:"shown.bs.tooltip",INSERTED:"inserted.bs.tooltip",CLICK:"click.bs.tooltip",FOCUSIN:"focusin.bs.tooltip",FOCUSOUT:"focusout.bs.tooltip",MOUSEENTER:"mouseenter.bs.tooltip",MOUSELEAVE:"mouseleave.bs.tooltip"},nn="fade",sn="show",on="show",rn="out",an=".tooltip-inner",ln=".modal",cn="hide.bs.modal",hn="hover",dn="focus";class un extends B{constructor(t,e){if(void 0===Fe)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t),this._isEnabled=!0,this._timeout=0,this._hoverState="",this._activeTrigger={},this._popper=null,this._config=this._getConfig(e),this.tip=null,this._setListeners()}static get Default(){return tn}static get NAME(){return Qi}static get Event(){return en}static get DefaultType(){return Zi}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(t){if(this._isEnabled)if(t){const e=this._initializeOnDelegatedTarget(t);e._activeTrigger.click=!e._activeTrigger.click,e._isWithActiveTrigger()?e._enter(null,e):e._leave(null,e)}else{if(this.getTipElement().classList.contains(sn))return void this._leave(null,this);this._enter(null,this)}}dispose(){clearTimeout(this._timeout),j.off(this._element.closest(ln),cn,this._hideModalHandler),this.tip&&this.tip.remove(),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this.isWithContent()||!this._isEnabled)return;const t=j.trigger(this._element,this.constructor.Event.SHOW),e=h(this._element),i=null===e?this._element.ownerDocument.documentElement.contains(this._element):e.contains(this._element);if(t.defaultPrevented||!i)return;"tooltip"===this.constructor.NAME&&this.tip&&this.getTitle()!==this.tip.querySelector(an).innerHTML&&(this._disposePopper(),this.tip.remove(),this.tip=null);const n=this.getTipElement(),s=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME);n.setAttribute("id",s),this._element.setAttribute("aria-describedby",s),this._config.animation&&n.classList.add(nn);const o="function"==typeof this._config.placement?this._config.placement.call(this,n,this._element):this._config.placement,r=this._getAttachment(o);this._addAttachmentClass(r);const{container:a}=this._config;H.set(n,this.constructor.DATA_KEY,this),this._element.ownerDocument.documentElement.contains(this.tip)||(a.append(n),j.trigger(this._element,this.constructor.Event.INSERTED)),this._popper?this._popper.update():this._popper=qe(this._element,n,this._getPopperConfig(r)),n.classList.add(sn);const l=this._resolvePossibleFunction(this._config.customClass);l&&n.classList.add(...l.split(" ")),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>{j.on(t,"mouseover",d)}));const c=this.tip.classList.contains(nn);this._queueCallback((()=>{const t=this._hoverState;this._hoverState=null,j.trigger(this._element,this.constructor.Event.SHOWN),t===rn&&this._leave(null,this)}),this.tip,c)}hide(){if(!this._popper)return;const t=this.getTipElement();if(j.trigger(this._element,this.constructor.Event.HIDE).defaultPrevented)return;t.classList.remove(sn),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._activeTrigger.click=!1,this._activeTrigger.focus=!1,this._activeTrigger.hover=!1;const e=this.tip.classList.contains(nn);this._queueCallback((()=>{this._isWithActiveTrigger()||(this._hoverState!==on&&t.remove(),this._cleanTipClass(),this._element.removeAttribute("aria-describedby"),j.trigger(this._element,this.constructor.Event.HIDDEN),this._disposePopper())}),this.tip,e),this._hoverState=""}update(){null!==this._popper&&this._popper.update()}isWithContent(){return Boolean(this.getTitle())}getTipElement(){if(this.tip)return this.tip;const t=document.createElement("div");t.innerHTML=this._config.template;const e=t.children[0];return this.setContent(e),e.classList.remove(nn,sn),this.tip=e,this.tip}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),an)}_sanitizeAndSetContent(t,e,i){const n=V.findOne(i,t);e||!n?this.setElementContent(n,e):n.remove()}setElementContent(t,e){if(null!==t)return o(e)?(e=r(e),void(this._config.html?e.parentNode!==t&&(t.innerHTML="",t.append(e)):t.textContent=e.textContent)):void(this._config.html?(this._config.sanitize&&(e=Yi(e,this._config.allowList,this._config.sanitizeFn)),t.innerHTML=e):t.textContent=e)}getTitle(){const t=this._element.getAttribute("data-bs-original-title")||this._config.title;return this._resolvePossibleFunction(t)}updateAttachment(t){return"right"===t?"end":"left"===t?"start":t}_initializeOnDelegatedTarget(t,e){return e||this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof 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Dn="toast",Sn="hide",Nn="show",In="showing",Pn={animation:"boolean",autohide:"boolean",delay:"number"},jn={animation:!0,autohide:!0,delay:5e3};class Mn extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._timeout=null,this._hasMouseInteraction=!1,this._hasKeyboardInteraction=!1,this._setListeners()}static get DefaultType(){return Pn}static get Default(){return jn}static get NAME(){return Dn}show(){j.trigger(this._element,"show.bs.toast").defaultPrevented||(this._clearTimeout(),this._config.animation&&this._element.classList.add("fade"),this._element.classList.remove(Sn),u(this._element),this._element.classList.add(Nn),this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.remove(In),j.trigger(this._element,"shown.bs.toast"),this._maybeScheduleHide()}),this._element,this._config.animation))}hide(){this._element.classList.contains(Nn)&&(j.trigger(this._element,"hide.bs.toast").defaultPrevented||(this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.add(Sn),this._element.classList.remove(In),this._element.classList.remove(Nn),j.trigger(this._element,"hidden.bs.toast")}),this._element,this._config.animation)))}dispose(){this._clearTimeout(),this._element.classList.contains(Nn)&&this._element.classList.remove(Nn),super.dispose()}_getConfig(t){return t={...jn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}},a(Dn,t,this.constructor.DefaultType),t}_maybeScheduleHide(){this._config.autohide&&(this._hasMouseInteraction||this._hasKeyboardInteraction||(this._timeout=setTimeout((()=>{this.hide()}),this._config.delay)))}_onInteraction(t,e){switch(t.type){case"mouseover":case"mouseout":this._hasMouseInteraction=e;break;case"focusin":case"focusout":this._hasKeyboardInteraction=e}if(e)return void this._clearTimeout();const i=t.relatedTarget;this._element===i||this._element.contains(i)||this._maybeScheduleHide()}_setListeners(){j.on(this._element,"mouseover.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"mouseout.bs.toast",(t=>this._onInteraction(t,!1))),j.on(this._element,"focusin.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"focusout.bs.toast",(t=>this._onInteraction(t,!1)))}_clearTimeout(){clearTimeout(this._timeout),this._timeout=null}static jQueryInterface(t){return this.each((function(){const e=Mn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}return R(Mn),g(Mn),{Alert:W,Button:z,Carousel:st,Collapse:pt,Dropdown:hi,Modal:Hi,Offcanvas:Fi,Popover:gn,ScrollSpy:An,Tab:xn,Toast:Mn,Tooltip:un}}));
+//# sourceMappingURL=bootstrap.bundle.min.js.map
\ No newline at end of file
diff --git a/stable/site_libs/clipboard/clipboard.min.js b/stable/site_libs/clipboard/clipboard.min.js
new file mode 100644
index 0000000000..1103f811ed
--- /dev/null
+++ b/stable/site_libs/clipboard/clipboard.min.js
@@ -0,0 +1,7 @@
+/*!
+ * clipboard.js v2.0.11
+ * https://clipboardjs.com/
+ *
+ * Licensed MIT © Zeno Rocha
+ */
+!function(t,e){"object"==typeof exports&&"object"==typeof module?module.exports=e():"function"==typeof define&&define.amd?define([],e):"object"==typeof exports?exports.ClipboardJS=e():t.ClipboardJS=e()}(this,function(){return n={686:function(t,e,n){"use strict";n.d(e,{default:function(){return b}});var e=n(279),i=n.n(e),e=n(370),u=n.n(e),e=n(817),r=n.n(e);function c(t){try{return document.execCommand(t)}catch(t){return}}var a=function(t){t=r()(t);return c("cut"),t};function o(t,e){var n,o,t=(n=t,o="rtl"===document.documentElement.getAttribute("dir"),(t=document.createElement("textarea")).style.fontSize="12pt",t.style.border="0",t.style.padding="0",t.style.margin="0",t.style.position="absolute",t.style[o?"right":"left"]="-9999px",o=window.pageYOffset||document.documentElement.scrollTop,t.style.top="".concat(o,"px"),t.setAttribute("readonly",""),t.value=n,t);return e.container.appendChild(t),e=r()(t),c("copy"),t.remove(),e}var f=function(t){var e=1<arguments.length&&void 0!==arguments[1]?arguments[1]:{container:document.body},n="";return"string"==typeof t?n=o(t,e):t instanceof HTMLInputElement&&!["text","search","url","tel","password"].includes(null==t?void 0:t.type)?n=o(t.value,e):(n=r()(t),c("copy")),n};function l(t){return(l="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(t)}var s=function(){var t=0<arguments.length&&void 0!==arguments[0]?arguments[0]:{},e=t.action,n=void 0===e?"copy":e,o=t.container,e=t.target,t=t.text;if("copy"!==n&&"cut"!==n)throw new Error('Invalid "action" value, use either "copy" or "cut"');if(void 0!==e){if(!e||"object"!==l(e)||1!==e.nodeType)throw new Error('Invalid "target" value, use a valid Element');if("copy"===n&&e.hasAttribute("disabled"))throw new Error('Invalid "target" attribute. 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diff --git a/stable/site_libs/cookie-consent/cookie-consent.css b/stable/site_libs/cookie-consent/cookie-consent.css
new file mode 100644
index 0000000000..2e49f612a3
--- /dev/null
+++ b/stable/site_libs/cookie-consent/cookie-consent.css
@@ -0,0 +1,4 @@
+div.cookie-consent-footer {
+  font-size: 0.8em;
+  text-decoration: none;
+}
diff --git a/stable/site_libs/cookie-consent/cookie-consent.js b/stable/site_libs/cookie-consent/cookie-consent.js
new file mode 100644
index 0000000000..21c77187f8
--- /dev/null
+++ b/stable/site_libs/cookie-consent/cookie-consent.js
@@ -0,0 +1 @@
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So können wir verstehen, wie wir unsere Website für Sie verbessern können.","pc_trck_text_4":"Die durch diese Tracking- und Performance-Cookies gesammelten Informationen identifizieren keinen einzelnen Besucher.","pc_trgt_text_1":"Targeting und Werbung Cookies","pc_trgt_text_2":"Diese Cookies werden genutzt, um Werbung anzuzeigen, die Sie aufgrund Ihrer Surfgewohnheiten wahrscheinlich interessieren wird.","pc_trgt_text_3":"Diese Cookies, die von unseren Inhalten und / oder Werbeanbietern bereitgestellt werden, können Informationen, die sie von unserer Website gesammelt haben, mit anderen Informationen kombinieren, welche sie durch Aktivitäten Ihres Webbrowsers in Ihrem Netzwerk von Websites gesammelt haben.","pc_trgt_text_4":"Wenn Sie diese Targeting- oder Werbe-Cookies entfernen oder deaktivieren, werden weiterhin Anzeigen angezeigt. Diese sind für Sie jedoch möglicherweise nicht relevant.","pc_yprivacy_text_1":"Ihre Privatsphäre ist uns wichtig","pc_yprivacy_text_2":"Cookies sind sehr kleine Textdateien, die auf Ihrem Rechner gespeichert werden, wenn Sie eine Website besuchen. Wir verwenden Cookies für eine Reihe von Auswertungen, um damit Ihren Besuch auf unserer Website kontinuierlich verbessern zu können (z. B. damit Ihnen Ihre Login-Daten erhalten bleiben).","pc_yprivacy_text_3":"Sie können Ihre Einstellungen ändern und verschiedenen Arten von Cookies erlauben, auf Ihrem Rechner gespeichert zu werden, während Sie unsere Webseite besuchen. Sie können auf Ihrem Rechner gespeicherte Cookies ebenso weitgehend wieder entfernen. Bitte bedenken Sie aber, dass dadurch Teile unserer Website möglicherweise nicht mehr in der gedachten Art und Weise nutzbar sind.","pc_yprivacy_title":"Ihre Privatsphäre","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Datenschutzrichtlinie</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Actif","always_active":"Toujours activé","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inactif","nb_agree":"J\'accepte","nb_changep":"Changer mes préférences","nb_ok":"OK","nb_reject":"Je refuse","nb_text":"Nous utilisons des cookies et d\'autres technologies de suivi pour améliorer votre expérience de navigation sur notre site, pour vous montrer un contenu personnalisé et des publicités ciblées, pour analyser le trafic de notre site et pour comprendre la provenance de nos visiteurs.","nb_title":"Nous utilisons des cookies","pc_fnct_text_1":"Cookies de Fonctionnalité","pc_fnct_text_2":"Ces cookies servent à vous offrir une expérience plus personnalisée sur notre site Web et à mémoriser les choix que vous faites lorsque vous utilisez notre site Web.","pc_fnct_text_3":"Par exemple, nous pouvons utiliser des cookies de fonctionnalité pour mémoriser vos préférences de langue ou vos identifiants de connexion.","pc_minfo_text_1":"Plus d\'information","pc_minfo_text_2":"Pour toute question relative à notre politique en matière de cookies et à vos choix, veuillez nous contacter.","pc_minfo_text_3":"Pour en savoir plus, merci de consulter notre <a href=\'%s\' target=\'_blank\'>Politique de confidentialité</a>.","pc_save":"Sauvegarder mes préférences","pc_sncssr_text_1":"Cookies strictement nécessaires","pc_sncssr_text_2":"Ces cookies sont essentiels pour vous fournir les services disponibles sur notre site Web et vous permettre d’utiliser certaines fonctionnalités de notre site Web.","pc_sncssr_text_3":"Sans ces cookies, nous ne pouvons pas vous fournir certains services sur notre site Web.","pc_title":"Espace de Préférences des Cookies","pc_trck_text_1":"Cookies de suivi et de performance","pc_trck_text_2":"Ces cookies sont utilisés pour collecter des informations permettant d\'analyser le trafic sur notre site et la manière dont les visiteurs utilisent notre site.","pc_trck_text_3":"Par exemple, ces cookies peuvent suivre des choses telles que le temps que vous passez sur le site Web ou les pages que vous visitez, ce qui nous aide à comprendre comment nous pouvons améliorer notre site Web pour vous.","pc_trck_text_4":"Les informations collectées via ces cookies de suivi et de performance n\' identifient aucun visiteur en particulier.","pc_trgt_text_1":"Cookies de ciblage et de publicité","pc_trgt_text_2":"Ces cookies sont utilisés pour afficher des publicités susceptibles de vous intéresser en fonction de vos habitudes de navigation.","pc_trgt_text_3":"Ces cookies, tels que servis par nos fournisseurs de contenu et / ou de publicité, peuvent associer des informations qu\'ils ont collectées sur notre site Web à d\'autres informations qu\'ils ont collectées de manière indépendante et concernant les activités du votre navigateur Web sur son réseau de sites Web.","pc_trgt_text_4":"Si vous choisissez de supprimer ou de désactiver ces cookies de ciblage ou de publicité, vous verrez toujours des annonces, mais elles risquent de ne pas être pertinentes.","pc_yprivacy_text_1":"Votre confidentialité est importante pour nous","pc_yprivacy_text_2":"Les cookies sont de très petits fichiers texte qui sont stockés sur votre ordinateur lorsque vous visitez un site Web. Nous utilisons des cookies à diverses fins et pour améliorer votre expérience en ligne sur notre site Web (par exemple, pour mémoriser les informations de connexion de votre compte).","pc_yprivacy_text_3":"Vous pouvez modifier vos préférences et refuser l\'enregistrement de certains types de cookies sur votre ordinateur lors de la navigation sur notre site. Vous pouvez également supprimer les cookies déjà stockés sur votre ordinateur, mais gardez à l\'esprit que leur suppression peut vous empêcher d\'utiliser des éléments de notre site Web.","pc_yprivacy_title":"Votre confidentialité","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Politique de confidentialité</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Activo","always_active":"Siempre activo","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inactivo","nb_agree":"Aceptar","nb_changep":"Configurar","nb_ok":"OK","nb_reject":"Renuncio","nb_text":"Usamos cookies y otras técnicas de rastreo para mejorar tu experiencia de navegación en nuestra web, para mostrarte contenidos personalizados y anuncios adecuados, para analizar el tráfico en nuestra web y para comprender de donde llegan nuestros visitantes.","nb_title":"Utilizamos cookies","pc_fnct_text_1":"Cookies de funcionalidad","pc_fnct_text_2":"Estas cookies son utilizadas para proveerte una experiencia más personalizada y recordar tus elecciones en nuestra web.","pc_fnct_text_3":"Por ejemplo, podemos utilizar cookies de funcionalidad para recordar tus preferencias de idioma o tus detalles de acceso.","pc_minfo_text_1":"Más información","pc_minfo_text_2":"Para cualquier pregunta en relación con nuestra política de cookies y tus preferencias, contacta con nosotros, por favor.","pc_minfo_text_3":"Para saber más, visita nuestra página sobre la <a href=\'%s\' target=\'_blank\'>Política de privacidad</a>.","pc_save":"Guardar mis preferencias","pc_sncssr_text_1":"Cookies estrictamente necesarias","pc_sncssr_text_2":"Estos cookies son esenciales para proveerte los servicios disponibles en nuestra web y para permitirte utilizar algunas características de nuestra web.","pc_sncssr_text_3":"Sin estas cookies, no podemos proveer algunos servicios de nuestro sitio web.","pc_title":"Centro de Preferencias de Cookies","pc_trck_text_1":"Cookies de rastreo y rendimiento","pc_trck_text_2":"Estas cookies son utilizadas para recopilar información, para analizar el tráfico y la forma en que los usuarios utilizan nuestra web.","pc_trck_text_3":"Por ejemplo, estas cookies pueden recopilar datos como cuánto tiempo llevas navegado en nuestro sitio web o qué páginas visitas, cosa que nos ayuda a comprender cómo podemos mejorar nuestra web para ti.","pc_trck_text_4":"La información recopilada con estas cookies de rastreo y rendimiento no identifican a ningún visitante individual.","pc_trgt_text_1":"Cookies de seguimiento y publicidad","pc_trgt_text_2":"Estas cookies son utilizadas para enseñarte anuncios que pueden ser interesantes basados en tus costumbres de navegación.","pc_trgt_text_3":"Estas cookies, servidas por nuestros proveedores de contenido y/o de publicidad, pueden combinar la información que ellos recogieron de nuestro sitio web con otra información recopilada por ellos en relación con las actividades de su navegador a través de su red de sitios web.","pc_trgt_text_4":"Si eliges cancelar o inhabilitar las cookies de seguimiento y publicidad, seguirás viendo anuncios pero estos podrían no ser de tu interés.","pc_yprivacy_text_1":"Tu privacidad es importante para nosotros","pc_yprivacy_text_2":"Las cookies son pequeños archivos de texto que se almacenan en tu navegador cuando visitas nuestra web. Utilizamos cookies para diferentes objetivos y para mejorar tu experiencia en nuestro sitio web (por ejemplo, para recordar tus detalles de acceso).","pc_yprivacy_text_3":"Puedes cambiar tus preferencias y rechazar que algunos tipos de cookies sean almacenados mientras estás navegando en nuestra web. También puedes cancelar cualquier cookie ya almacenada en tu navegador, pero recuerda que cancelar las cookies puede impedirte utilizar algunas partes de nuestra web.","pc_yprivacy_title":"Tu privacidad","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Política de privacidad</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Actiu","always_active":"Sempre actiu","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inactiu","nb_agree":"Estic d’acord","nb_changep":"Canviar preferències","nb_ok":"OK","nb_reject":"Declino","nb_text":"Fem servir cookies i altres tecnologies de seguiment per millorar la teva experiència de navegació al nostre lloc web, per mostrar-te contingut personalitzat i anuncis interessants per a tu, per analitzar el nostre tràfic i entendre d’on venen els nostres visitants.","nb_title":"Fem servir cookies","pc_fnct_text_1":"Cookies de funcionalitat","pc_fnct_text_2":"Aquestes cookies ens permeten oferir-vos una experiència personalitzada i recordar la vostra configuració quan feu servir el nostre lloc web.","pc_fnct_text_3":"Per exemple, podem fer servir funcionalitat per recordar el vostre idioma o les vostres credencials.","pc_minfo_text_1":"Més informació","pc_minfo_text_2":"Per qualsevol pregunta relacionada amb la nostra política de cookies i les vostres opcions, si us plau contacti’ns.","pc_minfo_text_3":"Per saber més, si us plau visiti la nostra <a href=\'%s\' target=\'_blank\'>Política de privacitat</a>.","pc_save":"Guarda les meves preferències","pc_sncssr_text_1":"Cookies estrictament necessàries","pc_sncssr_text_2":"Aquestes cookies són essencials per oferir-vos el nostres serveis i funcionalitats al nostre lloc web.","pc_sncssr_text_3":"Sense aquestes cookies, no us podem oferir alguns serveis.","pc_title":"Centre de Preferències de Cookies","pc_trck_text_1":"Cookies de seguiment i rendiment","pc_trck_text_2":"Aquestes cookies es fan servir per recollir informació, analitzar el tràfic i veure com es fa servir el nostre lloc web.","pc_trck_text_3":"Per exemple, aquestes cookies podrien fer el seguiment de quant de temps visiteu el nostre web o quines pàgines visiteu les quals ens poden ajudar a entendre com millorar el lloc web per vosaltres.","pc_trck_text_4":"La informació recollida gràcies a aquestes cookies de seguiment i rendiment no us identifiquen de forma individual.","pc_trgt_text_1":"Cookies de publicitat i focalització","pc_trgt_text_2":"Aquestes cookies es fan servir per mostrar anuncis que poden ser del vostre interès basats en els vostres hàbits d’us.","pc_trgt_text_3":"Aquestes cookies, servides tal i com ho fan els nostres proveïdors de publicitat i contingut, poden combinar informació recollida al nostre lloc web amb altra informació que hagin recollit independentment relacionada amb activitat a la seva xarxa de llocs web.","pc_trgt_text_4":"Si vostè decideix eliminar o deshabilitat aquestes cookies, encara veurà publicitat però aquesta pot no ser rellevant per vostè.","pc_yprivacy_text_1":"La vostra privacitat és important per nosaltres","pc_yprivacy_text_2":"Les cookies són uns arxius de text molt petits que es guarden al vostre  ordinador quan visiteu un lloc web. Fem servir cookies per una varietat de finalitats i millorar la vostra experiència al nostre lloc web (per exemple, per recordar les vostres credencials).","pc_yprivacy_text_3":"Pot canviar les vostres preferències i rebutjar l’emmagatzematge al vostre ordinador de certs tipus de cookies mentres navega pel nostre. Pot eliminar qualsevol cookie ja emmagatzemada al vostre ordinador, però tingui en compte que eliminar cookies pot impedir que faci servir parts del nostre lloc web.","pc_yprivacy_title":"La vostra privacitat","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Política de privacitat</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Attivo","always_active":"Sempre attivo","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inattivo","nb_agree":"Accetto","nb_changep":"Cambia le mie impostazioni","nb_ok":"OK","nb_reject":"Rifiuto","nb_text":"Noi usiamo i cookies e altre tecniche di tracciamento per migliorare la tua esperienza di navigazione nel nostro sito, per mostrarti contenuti personalizzati e annunci mirati, per analizzare il traffico sul nostro sito, e per capire da dove arrivano i nostri visitatori.","nb_title":"Noi usiamo i cookies","pc_fnct_text_1":"Cookies funzionali","pc_fnct_text_2":"Questi cookies sono utilizzati per offrirti un’esperienza più personalizzata nel nostro sito e per ricordare le scelte che hai fatto mentre usavi il nostro sito.","pc_fnct_text_3":"Per esempio, possiamo usare cookies funzionali per memorizzare le tue preferenze sulla lingua o i tuoi dettagli di accesso.","pc_minfo_text_1":"Più informazioni","pc_minfo_text_2":"Per qualsiasi domanda relativa alla nostra politica sui cookies e le tue scelte, per favore contattaci.","pc_minfo_text_3":"Per saperne di più, visita per favore la nostra pagina sulla <a href=\'%s\' target=\'_blank\'>Politica sulla riservatezza</a>.","pc_save":"Salva le mie impostazioni","pc_sncssr_text_1":"Cookies strettamente necessari","pc_sncssr_text_2":"Questi cookies sono essenziali per fornirti i servizi disponibili nel nostro sito e per renderti disponibili alcune funzionalità del nostro sito web.","pc_sncssr_text_3":"Senza questi cookies, non possiamo fornirti alcuni servizi del nostro sito.","pc_title":"Centro Preferenze sui Cookies","pc_trck_text_1":"Cookies di tracciamento e prestazione","pc_trck_text_2":"Questi cookies sono utilizzati per raccogliere informazioni per analizzare il traffico verso il nostro sito e il modo in cui i visitatori utilizzano il nostro sito.","pc_trck_text_3":"Per esempio, questi cookies possono tracciare cose come quanto a lungo ti fermi nel nostro sito o le pagine che visiti, cosa che ci aiuta a capire come possiamo migliorare il nostro sito per te.","pc_trck_text_4":"Le informazioni raccolte attraverso questi cookies di tracciamento e performance non identificano alcun visitatore individuale.","pc_trgt_text_1":"Cookies di targeting e pubblicità","pc_trgt_text_2":"Questi cookies sono usati per mostrare annunci pubblicitari che possano verosimilmente essere di tuo interesse in base alle tue abitudini di navigazione.","pc_trgt_text_3":"Questi cookies, cosí come forniti dai nostri fornitori di  contenuti o annunci pubblicitari, possono combinare le informazioni che raccolgono dal nostro sito web con quelle che hanno indipendentemente raccolto in relazione all’attività del tuo browser attraverso la loro rete di siti web.","pc_trgt_text_4":"Se scegli di rimuovere o disabilitare questo tipo di cookies di targeting e pubblicità, vedrai ancora annunci pubblicitari ma potrebbero essere irrilevanti per te.","pc_yprivacy_text_1":"La tua privacy è importante per noi","pc_yprivacy_text_2":"I cookies sono dei piccolissimi file di testo che vengono memorizzati nel tuo computer quando visiti un sito web. Noi usiamo i cookies per una varietà di scopi e per migliorare la tua esperienza online nel nostro sito web (per esempio, per ricordare i tuoi dettagli di accesso).","pc_yprivacy_text_3":"Tu puoi cambiare le tue impostazioni e rifiutare che alcuni tipi di cookies vengano memorizzati sul tuo computer mentre stai navigando nel nostro sito web. Puoi anche rimuovere qualsiasi cookie già memorizzato nel tuo computer, ma ricorda che cancellare i cookies può impedirti di utilizzare alcune parti del nostro sito.","pc_yprivacy_title":"La tua privacy","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Politica sulla riservatezza</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktiv","always_active":"Alltid aktiv","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inaktiv","nb_agree":"Jag accepterar","nb_changep":"Ändra mina inställningar","nb_ok":"OK","nb_reject":"Jag avböjer","nb_text":"Vi använder cookies och andra spårningsteknologier för att förbättra din surfupplevelse på vår webbplats, för att visa dig personligt innehåll och riktade annonser, för att analysera vår webbplatstrafik och för att förstå var våra besökare kommer ifrån.","nb_title":"Vi använder oss av cookies","pc_fnct_text_1":"Funktionella cookies","pc_fnct_text_2":"Dessa cookies används för att ge dig en mer personlig upplevelse på vår webbplats och för att komma ihåg val du gör när du använder vår webbplats.","pc_fnct_text_3":"Vi kan till exempel använda funktions cookies för att komma ihåg dina språkinställningar eller dina inloggningsuppgifter.","pc_minfo_text_1":"Mer information","pc_minfo_text_2":"Kontakta oss om du har frågor angående vår policy om cookies och dina val.","pc_minfo_text_3":"För att ta reda på mer, läs vår <a href=\'%s\' target=\'_blank\'>integritetspolicy</a>.","pc_save":"Spara mina inställningar","pc_sncssr_text_1":"Absolut nödvändiga cookies","pc_sncssr_text_2":"Dessa cookies är viktiga för att förse dig med tjänster som är tillgängliga via vår webbplats och för att du ska kunna använda vissa funktioner på vår webbplats.","pc_sncssr_text_3":"Utan dessa cookies kan vi inte tillhandahålla vissa tjänster på vår webbplats.","pc_title":"Cookies Inställningar","pc_trck_text_1":"Spårnings- och prestanda cookies","pc_trck_text_2":"Dessa cookies används för att samla in information för att analysera trafiken på vår webbplats och hur våra besökare använder den.","pc_trck_text_3":"Dessa cookies kan till exempel spåra hur länge du spenderar på webbplatsen eller vilka sidor du besöker vilket hjälper oss att förstå hur vi kan förbättra vår webbplats för dig.","pc_trck_text_4":"Informationen som samlas in genom dessa spårnings- och prestanda cookies identifierar ingen enskild besökare.","pc_trgt_text_1":"Inriktnings- och reklamcookies","pc_trgt_text_2":"Dessa cookies används för att visa reklam som sannolikt kommer att vara av intresse för dig baserat på dina surfvanor.","pc_trgt_text_3":"Dessa kakor, som betjänas av vårt innehåll och / eller reklamleverantörer, kan kombinera information som de samlat in från vår webbplats med annan information som de har samlat in oberoende om din webbläsares aktiviteter i deras nätverk av webbplatser.","pc_trgt_text_4":"Om du väljer att ta bort eller inaktivera dessa inriktnings- och reklamcookies kommer du fortfarande att se annonser men de kanske inte är relevanta för dig.","pc_yprivacy_text_1":"Din integritet är viktig för oss","pc_yprivacy_text_2":"Cookies är mycket små textfiler som lagras på din dator när du besöker en webbplats. Vi använder cookies till olika ändamål och för att kunna förbättra din onlineupplevelse på vår webbplats (till exempel som att komma ihåg dina inloggningsuppgifter).","pc_yprivacy_text_3":"Du kan ändra dina inställningar och avaktivera vissa typer av cookies som ska lagras på din dator när du surfar på vår webbplats. Du kan också ta bort alla cookies som redan är lagrade på din dator, men kom ihåg att radering av cookies kan hindra dig från att använda delar av vår webbplats.","pc_yprivacy_title":"Din integritet","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Integritetspolicy</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Actief","always_active":"Altijd actief","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inactief","nb_agree":"Ik ga akkoord","nb_changep":"Wijzig mijn voorkeuren","nb_ok":"OK","nb_reject":"Ik weiger","nb_text":"Wij maken gebruik van cookies en andere tracking-technologieën om uw surfervaring op onze website te verbeteren, om gepersonaliseerde inhoud en advertenties te tonen, om ons websiteverkeer te analyseren en om te begrijpen waar onze bezoekers vandaan komen.","nb_title":"Wij gebruiken cookies","pc_fnct_text_1":"Functionele cookies","pc_fnct_text_2":"Deze cookies worden gebruikt om u een persoonlijkere ervaring op onze website te bieden en om keuzes te onthouden die u maakt wanneer u onze website gebruikt.","pc_fnct_text_3":"Functionele cookies worden bijvoorbeeld gebruikt om uw taalvoorkeuren of inloggegevens te onthouden.","pc_minfo_text_1":"Meer informatie","pc_minfo_text_2":"Voor vragen in verband met ons cookiebeleid en uw keuzes kan u ons contacteren.","pc_minfo_text_3":"Voor meer informatie, bezoek ons <a href=\'%s\' target=\'_blank\'>Privacybeleid</a>.","pc_save":"Sla mijn voorkeuren op","pc_sncssr_text_1":"Strikt noodzakelijke cookies","pc_sncssr_text_2":"Deze cookies zijn essentieel om u de diensten aan te bieden die beschikbaar zijn via onze website en om u in staat te stellen bepaalde functies van onze website te gebruiken.","pc_sncssr_text_3":"Zonder deze cookies kunnen we u bepaalde diensten op onze website niet aanbieden.","pc_title":"Cookie instellingen","pc_trck_text_1":"Tracking- en prestatie cookies","pc_trck_text_2":"Deze cookies worden gebruikt om informatie te verzamelen om het verkeer naar onze website te analyseren en hoe bezoekers onze website gebruiken.","pc_trck_text_3":"Deze cookies kunnen gegevens zoals hoe lang u op de website doorbrengt of de pagina\'s die u bezoekt, bijhouden. Dit helpt ons te begrijpen hoe we onze website voor u kunnen verbeteren.","pc_trck_text_4":"Individuele bezoekers kunnen niet geïdentificeerd worden aan hand van de informatie in deze cookies.","pc_trgt_text_1":"Targeting- en advertentie cookies","pc_trgt_text_2":"Deze cookies worden gebruikt om advertenties weer te geven die u waarschijnlijk interesseren op basis van uw surfgedrag.","pc_trgt_text_3":"Deze cookies, zoals aangeboden op basis van de inhoud van onze site en/of reclame aanbieders, kunnen informatie die ze van onze website hebben verzameld combineren met andere informatie die ze onafhankelijk hebben verzameld met betrekking tot de activiteiten van uw webbrowser via hun netwerk van websites.","pc_trgt_text_4":"Als u ervoor kiest deze targeting- of advertentiecookies te verwijderen of uit te schakelen, ziet u nog steeds advertenties, maar deze zijn mogelijk niet relevant voor u.","pc_yprivacy_text_1":"Uw privacy is belangrijk voor ons","pc_yprivacy_text_2":"Cookies zijn kleine tekstbestanden die bij het bezoeken van een website op uw computer worden opgeslagen. We gebruiken cookies voor verschillende doeleinden en om uw online ervaring op onze website te verbeteren (bijvoorbeeld om de inloggegevens voor uw account te onthouden).","pc_yprivacy_text_3":"U kunt uw voorkeuren wijzigen en bepaalde soorten cookies weigeren die op uw computer worden opgeslagen tijdens het browsen op onze website. U kunt ook alle cookies verwijderen die al op uw computer zijn opgeslagen, maar houd er rekening mee dat het verwijderen van cookies ertoe kan leiden dat u delen van onze website niet kunt gebruiken.","pc_yprivacy_title":"Jouw privacy","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Privacybeleid</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Ativo","always_active":"Sempre ativo","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inativo","nb_agree":"Concordo","nb_changep":"Alterar as minhas preferências","nb_ok":"OK","nb_reject":"Eu recuso","nb_text":"Utilizamos cookies e outras tecnologias de medição para melhorar a sua experiência de navegação no nosso site, de forma a mostrar conteúdo personalizado, anúncios direcionados, analisar o tráfego do site e entender de onde vêm os visitantes.","nb_title":"O nosso site usa cookies","pc_fnct_text_1":"Cookies de funcionalidade","pc_fnct_text_2":"Estes cookies são usados ​​para fornecer uma experiência mais personalizada no nosso site e para lembrar as escolhas que faz ao usar o nosso site.","pc_fnct_text_3":"Por exemplo, podemos usar cookies de funcionalidade para se lembrar das suas preferências de idioma e/ ou os seus detalhes de login.","pc_minfo_text_1":"Mais Informações","pc_minfo_text_2":"Para qualquer dúvida sobre a nossa política de cookies e as suas opções, entre em contato connosco.","pc_minfo_text_3":"Para obter mais detalhes, por favor consulte a nossa <a href=\'%s\' target=\'_blank\'>Política de Privacidade</a>.","pc_save":"Guardar as minhas preferências","pc_sncssr_text_1":"Cookies estritamente necessários","pc_sncssr_text_2":"Estes cookies são essenciais para fornecer serviços disponíveis no nosso site e permitir que possa usar determinados recursos no nosso site.","pc_sncssr_text_3":"Sem estes cookies, não podemos fornecer certos serviços no nosso site.","pc_title":"Centro de preferências de cookies","pc_trck_text_1":"Cookies de medição e desempenho","pc_trck_text_2":"Estes cookies são usados ​​para coletar informações para analisar o tráfego no nosso site e entender como é que os visitantes estão a usar o nosso site.","pc_trck_text_3":"Por exemplo, estes cookies podem medir fatores como o tempo despendido no site ou as páginas visitadas, isto vai permitir entender como podemos melhorar o nosso site para os utilizadores.","pc_trck_text_4":"As informações coletadas por meio destes cookies de medição e desempenho não identificam nenhum visitante individual.","pc_trgt_text_1":"Cookies de segmentação e publicidade","pc_trgt_text_2":"Estes cookies são usados ​​para mostrar publicidade que provavelmente lhe pode interessar com base nos seus hábitos e comportamentos de navegação.","pc_trgt_text_3":"Estes cookies, servidos pelo nosso conteúdo e/ ou fornecedores de publicidade, podem combinar as informações coletadas no nosso site com outras informações coletadas independentemente relacionadas com as atividades na rede de sites do seu navegador.","pc_trgt_text_4":"Se optar por remover ou desativar estes cookies de segmentação ou publicidade, ainda verá anúncios, mas estes poderão não ser relevantes para si.","pc_yprivacy_text_1":"A sua privacidade é importante para nós","pc_yprivacy_text_2":"Cookies são pequenos arquivos de texto que são armazenados no seu computador quando visita um site. Utilizamos cookies para diversos fins e para aprimorar sua experiência no nosso site (por exemplo, para se lembrar dos detalhes de login da sua conta).","pc_yprivacy_text_3":"Pode alterar as suas preferências e recusar o armazenamento de certos tipos de cookies no seu computador enquanto navega no nosso site. Pode também remover todos os cookies já armazenados no seu computador, mas lembre-se de que a exclusão de cookies pode impedir o uso de determinadas áreas no nosso site.","pc_yprivacy_title":"A sua privacidade","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Política de Privacidade</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Päällä","always_active":"Aina päällä","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Pois päältä","nb_agree":"Hyväksyn","nb_changep":"Muuta asetuksiani","nb_ok":"OK","nb_reject":"Kieltäydyn","nb_text":"Käytämme evästeitä ja muita seurantateknologioita parantaaksemme käyttäjäkokemusta verkkosivustollamme, näyttääksemme sinulle personoituja sisältöjä ja mainoksia, analysoidaksemme verkkoliikennettä sekä lisätäksemme ymmärrystämme käyttäjiemme sijainnista.","nb_title":"Käytämme evästeitä","pc_fnct_text_1":"Toiminnallisuusevästeet","pc_fnct_text_2":"Näitä evästeitä käytetään personoidumman käyttäjäkokemuksen luomiseksi sekä valintojesi tallentamiseksi sivustollamme.","pc_fnct_text_3":"Esim. voimme käyttää toiminnallisuusevästeitä muistaaksemme kielivalintasi sekä kirjautumistietosi.","pc_minfo_text_1":"Lisätietoa","pc_minfo_text_2":"Evästeisiin liittyvissä kysymyksissä ole hyvä ja ota meihin yhteyttä.","pc_minfo_text_3":"Lue lisää <a href=\'%s\' target=\'_blank\'>Tietosuojakäytäntö</a>.","pc_save":"Tallenna asetukseni","pc_sncssr_text_1":"Tärkeät evästeet","pc_sncssr_text_2":"Nämä evästeet mahdollistavat verkkosivustomme palveluiden sekä tiettyjen ominaisuuksien käyttämisen.","pc_sncssr_text_3":"Ilman näitä evästeitä emme voi tarjota sinulle tiettyjä palveluita sivustollamme.","pc_title":"Evästeasetukset","pc_trck_text_1":"Seuranta- ja tehokkuusevästeet","pc_trck_text_2":"Näiden evästeiden avulla kerätään tietoa sivustomme liikenteestä sekä käyttötavoista.","pc_trck_text_3":"Esim. nämä evästeet voivat seurata sitä, paljonko aikaa vietät sivustollamme, mikä auttaa meitä parantamaan sivustomme käyttökokemusta jatkossa.","pc_trck_text_4":"Näiden evästeiden avulla kerätty tietoa ei voida yhdistää yksittäiseen käyttäjään.","pc_trgt_text_1":"Kohdennus- ja mainosevästeet","pc_trgt_text_2":"Näitä evästeitä käytetään näyttämään mainoksia, jotka selauskäytöksesi perusteella todennäköisesti kiinnostavat sinua.","pc_trgt_text_3":"Nämä sisältö- ja/tai mainoskumppanimme tarjoamat evästeet voivat yhdistää sivustoltamme kerättyä tietoa muilta heidän verkostoonsa kuuluvilta sivustoilta kerättyihin tietoihin.","pc_trgt_text_4":"Jos päätät poistaa tai kytkeä pois päältä nämä kohdennus- ja mainosevästeet, näet yhä mainoksia, mutta ne eivät välttämättä ole sinulle oleellisia.","pc_yprivacy_text_1":"Yksityisyytesi on meille tärkeää","pc_yprivacy_text_2":"Evästeet ovat pieniä tekstitiedostoja, jotka tallennetaan laitteeseesi verkkosivulla vieraillessasi. Käytämme evästeitä useaan tarkoitukseen ja parantaaksesi käyttökokemustasi verkkosivustollamme (esim. muistaaksemme kirjautumistietosi).","pc_yprivacy_text_3":"Voit muuttaa asetuksiasi ja kieltää sivustoltamme tiettyjen evästetyyppien tallentamisen laitteellesi. Voit myös poistaa minkä tahansa jo tallennetun evästeen laitteeltasi, mutta huomaathan, että evästeiden poistaminen saattaa estää sinua käyttämästä osaa sivustomme sisällöstä.","pc_yprivacy_title":"Yksityisyytesi","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Tietosuojakäytäntö</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktív","always_active":"Mindig aktív","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inaktív","nb_agree":"Elfogadom","nb_changep":"Beállítások megváltoztatása","nb_ok":"OK","nb_reject":"Elutasítom","nb_text":"Az oldal sütiket és egyéb nyomkövető technológiákat alkalmaz, hogy javítsa a böngészési élményét, azzal hogy személyre szabott tartalmakat és célzott hirdetéseket jelenít meg, és elemzi a weboldalunk forgalmát, hogy megtudjuk honnan érkeztek a látogatóink.","nb_title":"Az oldal sütiket használ","pc_fnct_text_1":"Funkcionális sütik","pc_fnct_text_2":"Ezeket a sütiket arra használjuk, hogy személyre szabottabb élményt nyújtsunk weboldalunkon, és hogy az oldal rögzítse a webhelyünk használata során tett döntéseket.","pc_fnct_text_3":"Például arra használhatunk funkcionális sütiket, hogy emlékezzünk a nyelvi beállításokra, vagy a bejelentkezési adataira.","pc_minfo_text_1":"Egyéb információk","pc_minfo_text_2":"A sütikre vonatkozó irányelveinkkel és az Ön választásával kapcsolatosan felmerülő bármilyen kérdésével keressen meg bennünket.","pc_minfo_text_3":"Ha többet szeretne megtudni, kérjük, keresse fel a <a href=\'%s\' target=\'_blank\'>Adatvédelmi irányelvek</a>.","pc_save":"Beállítások mentése","pc_sncssr_text_1":"Feltétlenül szükséges sütik","pc_sncssr_text_2":"Ezek a sütik elengedhetetlenek a weboldalunkon elérhető szolgáltatások nyújtásához, valamint weboldalunk bizonyos funkcióinak használatához.","pc_sncssr_text_3":"A feltétlenül szükséges sütik használata nélkül weboldalunkon nem tudunk bizonyos szolgáltatásokat nyújtani Önnek.","pc_title":"Sütikre beállítási központ","pc_trck_text_1":"Követési és teljesítménnyel kapcsolatos sütik","pc_trck_text_2":"Ezeket a sütiket arra használjuk, hogy információkat gyűjtsünk weboldalunk forgalmáról és látogatóiról, webhelyünk használatának elemzéséhez.","pc_trck_text_3":"Például ezek a sütik nyomon követhetik a webhelyen töltött időt vagy a meglátogatott oldalakat, amely segít megérteni, hogyan javíthatjuk webhelyünket az Ön nagyobb megelégedettségére.","pc_trck_text_4":"Ezekkel a nyomkövető és teljesítménnyel kapcsolatos sütikkel összegyűjtött információk egyetlen személyt sem azonosítanak.","pc_trgt_text_1":"Célirányos és hirdetési sütik","pc_trgt_text_2":"Ezeket a sütiket olyan hirdetések megjelenítésére használjuk, amelyek valószínűleg érdekli Önt a böngészési szokásai alapján.","pc_trgt_text_3":"Ezek a sütik, amelyeket a tartalom és / vagy a reklámszolgáltatók szolgáltatnak, egyesíthetik a weboldalunktól gyűjtött információkat más információkkal, amelyeket önállóan összegyűjtöttek az Ön böngészőjének tevékenységeivel kapcsolatban a webhely-hálózaton keresztül.","pc_trgt_text_4":"Ha Ön úgy dönt, hogy eltávolítja vagy letiltja ezeket a célirányos vagy hirdetési sütiket, akkor is látni fogja a hirdetéseket, de lehet, hogy nem lesznek relevánsak az Ön számára.","pc_yprivacy_text_1":"Az ön adatainak védelem fontos számunkra","pc_yprivacy_text_2":"A sütik egészen kicsi szöveges fájlok, amelyeket a számítógépén tárolnak, amikor meglátogat egy weboldalt. Sütiket használunk különféle célokra, és weboldalunkon az online élmény fokozása érdekében (például a fiókjának bejelentkezési adatainak megjegyzésére).","pc_yprivacy_text_3":"Webhelyünk böngészése közben megváltoztathatja a beállításait, és elutasíthatja a számítógépén tárolni kívánt bizonyos típusú sütik használatát. A számítógépen már tárolt sütiket eltávolíthatja, de ne feledje, hogy a sütik törlése megakadályozhatja weboldalunk egyes részeinek használatát.","pc_yprivacy_title":"Az ön adatai védelme","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Adatvédelmi irányelvek</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktivno","always_active":"Uvijek aktivno","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktivno","nb_agree":"Slažem se","nb_changep":"Promjeni moje postavke","nb_ok":"OK","nb_reject":"Odbijam","nb_text":"Koristimo kolačiće i druge tehnologije praćenja da bismo poboljšali vaše korisničko iskustvo na našoj web stranici, kako bismo vam prikazali personalizirani sadržaj i ciljane oglase, analizirali promet na našoj web stranici i razumjeli odakle dolaze naši posjetitelji.","nb_title":"Mi koristimo kolačiće","pc_fnct_text_1":"Kolačići funkcionalnosti","pc_fnct_text_2":"Ovi se kolačići koriste kako bi vam pružili personalizirano korisničko iskustvo na našoj web stranici i za pamćenje izbora koje napravite kada koristite našu web stranicu.","pc_fnct_text_3":"Na primjer, možemo koristiti kolačiće funkcionalnosti da bismo zapamtili vaše jezične postavke ili upamtili vaše podatke za prijavu.","pc_minfo_text_1":"Više informacija","pc_minfo_text_2":"Za sve upite vezane uz naša pravila o kolačićima i vašim izborima, molimo da nas kontaktirate.","pc_minfo_text_3":"Da bi saznali više, posjetite naša <a href=\'%s\' target=\'_blank\'>Pravila o privatnosti</a>.","pc_save":"Spremi moje postavke","pc_sncssr_text_1":"Strogo potrebni kolačići","pc_sncssr_text_2":"Ovi su kolačići neophodni za pružanje usluga dostupnih putem naše web stranice i omogućavanje korištenja određenih značajki naše web stranice.","pc_sncssr_text_3":"Bez ovih kolačića ne možemo vam pružiti određene usluge na našoj web stranici.","pc_title":"Centar za postavke kolačića","pc_trck_text_1":"Kolačići za praćenje i performanse","pc_trck_text_2":"Ovi se kolačići koriste za prikupljanje podataka za analizu prometa na našoj web stranici i za informaciju kako posjetitelji koriste našu web stranicu.","pc_trck_text_3":"Na primjer, ti kolačići mogu pratiti stvari poput dugovanja na web stranici ili stranicama koje posjetite što nam pomaže da shvatimo kako možemo poboljšati vaše korisničko iskustvo na našoj web stranici.","pc_trck_text_4":"Informacije prikupljene ovim praćenjem i kolačići izvedbe ne identificiraju nijednog pojedinačnog posjetitelja.","pc_trgt_text_1":"Kolačići za ciljano oglašavanje","pc_trgt_text_2":"Ovi se kolačići koriste za prikazivanje oglasa koji bi vas mogli zanimati na temelju vaših navika pregledavanja web stranica.","pc_trgt_text_3":"Ovi kolačići, posluženi od naših pružatelja sadržaja i / ili oglašavanja, mogu kombinirati podatke koje su prikupili s naše web stranice s drugim podacima koje su neovisno prikupili, a odnose se na aktivnosti vašeg web preglednika kroz njihovu mrežu web stranica.","pc_trgt_text_4":"Ako odlučite ukloniti ili onemogućiti ove kolačiće za ciljano oglašavanje, i dalje ćete vidjeti oglase, ali oni možda nisu relevantni za vas.","pc_yprivacy_text_1":"Vaša privatnost nam je važna","pc_yprivacy_text_2":"Kolačići su vrlo male tekstualne datoteke koje se pohranjuju na vašem računalu kada posjetite web stranicu. Mi koristimo kolačiće za različite svrhe i za poboljšanje vašeg mrežnog iskustva na našoj web stranici (na primjer, za pamćenje podataka za prijavu na vaš korisnički račun).","pc_yprivacy_text_3":"Možete promijeniti svoje postavke i odbiti određene vrste kolačića koji će se pohraniti na vašem računalu tijekom pregledavanja naše web stranice. Također možete ukloniti sve kolačiće koji su već pohranjeni na vašem računalu, ali imajte na umu da vas brisanje kolačića može spriječiti da koristite dijelove naše web stranice.","pc_yprivacy_title":"Vaša privatnost","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Pravila o privatnosti</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktivní","always_active":"Vždy aktivní","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktivní","nb_agree":"Souhlasím","nb_changep":"Upravit mé předvolby","nb_ok":"OK","nb_reject":"Odmítám","nb_text":"Tyto webové stránky používají soubory cookies a další sledovací nástroje s cílem vylepšení uživatelského prostředí, zobrazení přizpůsobeného obsahu a  reklam, analýzy návštěvnosti webových stránek a zjištění zdroje návštěvnosti.","nb_title":"Používáme soubory cookies","pc_fnct_text_1":"Cookies pro funkcionality","pc_fnct_text_2":"Tyto soubory cookie se používají k tomu, aby vám na našich webových stránkách poskytovaly personalizovaný uživatelský zážitek a aby si pamatovaly vaše volby, které jste použili při používání našich webových stránek.","pc_fnct_text_3":"Můžeme například používat soubory cookie k zapamatování vašeho jazyka nebo k zapamatování vašich přihlašovacích údajů.","pc_minfo_text_1":"Další informace","pc_minfo_text_2":"V případě jakýchkoliv dotazů  ohledně našich zásad týkajících se souborů cookie a vašich možností nás prosím kontaktujte.","pc_minfo_text_3":"Pro více informací navštivte naši stránku <a href=\'%s\' target=\'_blank\'>Zásady ochrany osobních údajů</a>.","pc_save":"Uložit mé předvolby","pc_sncssr_text_1":"Bezpodmínečně nutné soubory cookies","pc_sncssr_text_2":"Tyto soubory cookies jsou nezbytné k tomu, abychom vám mohli poskytovat služby dostupné prostřednictvím našeho webu a abychom vám umožnili používat určité funkce našeho webu.","pc_sncssr_text_3":"Bez těchto cookies vám nemůžeme na naší webové stránce poskytovat určité služby.","pc_title":"Centrum předvoleb souborů Cookies","pc_trck_text_1":"Sledovací a výkonnostní soubory cookies","pc_trck_text_2":"Tyto soubory cookies se používají ke shromažďování informací pro analýzu provozu na našich webových stránkách a sledování používání našich webových stránek uživateli.","pc_trck_text_3":"Tyto soubory cookies mohou například sledovat věci jako je doba kterou na webu trávíte, nebo stránky, které navštěvujete, což nám pomáhá pochopit, jak pro vás můžeme vylepšit náš web.","pc_trck_text_4":"Informace shromážděné prostřednictvím těchto sledovacích a výkonnostních cookies neidentifikují žádné osoby.","pc_trgt_text_1":"Cookies pro cílení a reklamu","pc_trgt_text_2":"Tyto soubory cookie se používají k zobrazování reklamy, která vás pravděpodobně bude zajímat na základě vašich zvyků při procházení.","pc_trgt_text_3":"Tyto soubory cookie, jsou požadovány námi/nebo poskytovateli reklam, mohou kombinovat informace shromážděné z našich webových stránek s dalšími informacemi, které nezávisle shromáždily z jiných webových stránek, týkající se činností vašeho internetového prohlížeče v rámci jejich reklamní sítě webových stránek.","pc_trgt_text_4":"Pokud se rozhodnete tyto soubory cookies pro cílení nebo reklamu odstranit nebo deaktivovat, budou se vám reklamy stále zobrazovat, ale nemusí pro vás být nadále personalizované a relevantní.","pc_yprivacy_text_1":"Vaše soukromí je pro nás důležité","pc_yprivacy_text_2":"Soubory cookies jsou velmi malé textové soubory, které se ukládají do vašeho zařízení při navštěvování webových stránek. Soubory Cookies používáme pro různé účely a pro vylepšení vašeho online zážitku na webové stránce (například pro zapamatování přihlašovacích údajů k vašemu účtu).","pc_yprivacy_text_3":"Při procházení našich webových stránek můžete změnit své předvolby a odmítnout určité typy cookies, které se mají ukládat do vašeho počítače. Můžete také odstranit všechny soubory cookie, které jsou již uloženy ve vašem počítači, ale mějte na paměti, že odstranění souborů cookie vám může zabránit v používání částí našeho webu.","pc_yprivacy_title":"Vaše soukromí","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Zásady ochrany osobních údajů</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktiv","always_active":"Altid aktiv","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inaktiv","nb_agree":"Jeg accepterer","nb_changep":"Skift indstillinger","nb_ok":"OK","nb_reject":"Jeg nægter","nb_text":"Vi bruger cookies og andre tracking teknologier for at forbedre din oplevelse på vores website, til at vise personaliseret indhold, målrettede annoncer og til at forstå hvor vores besøgende kommer fra.","nb_title":"Vi bruger cookies","pc_fnct_text_1":"Funktions cookies","pc_fnct_text_2":"Disse cookies anvendes for at kunne give dig en personaliseret oplevelse af vores hjemmeside, og for at kunne huske valg du har truffet.","pc_fnct_text_3":"Eksempelvis kan vi bruge funktions cookies til at huske sprog-indstillinger eller dine login informationer.","pc_minfo_text_1":"Mere information","pc_minfo_text_2":"Har du spørgsmål vedr. vores cookiepolitik og dine valgmuligheder, så kontakt os venligst.","pc_minfo_text_3":"For at finde ud af mere, så læs venligst vores <a href=\'%s\' target=\'_blank\'>Fortrolighedspolitik</a>.","pc_save":"Gem mine indstillinger","pc_sncssr_text_1":"Nødvendige cookies","pc_sncssr_text_2":"Disse Cookies er essentielle for at du kan bruge vores hjemmeside.","pc_sncssr_text_3":"Uden disse cookies kan vi ikke garantere vores hjemmeside virker ordentligt.","pc_title":"Cookie indstillinger","pc_trck_text_1":"Tracking og performance cookies","pc_trck_text_2":"Disse cookies anvendes til at analysere besøg på vores hjemmeside, og hvordan du bruger vores hjemmeside.","pc_trck_text_3":"Eksempelvis kan vi tracke hvor lang tid du bruger hjemmesiden, eller hvilke sider du kigger på. Det hjælper os til at forstå hvordan vi kan forbedre hjemmesiden.","pc_trck_text_4":"Informationerne kan ikke identificere dig som individ og er derfor anonyme.","pc_trgt_text_1":"Målretning og annoncecookies","pc_trgt_text_2":"Disse cookies anvendes for at kunne vise annoncer, som sandsynligvis er interessante for dig, baseret på dine browser profil.","pc_trgt_text_3":"Disse cookies, som sættes af vores indhold og/eller annoncepartnere, kan kombinere information fra flere hjemmesider i hele det netværk som partnerne styrer.","pc_trgt_text_4":"Hvis du deaktiverer denne indstilling vil du fortsat se reklamer, men de vil ikke længere være målrettet til dig.","pc_yprivacy_text_1":"Dit privatliv er vigtigt for os","pc_yprivacy_text_2":"Cookies er en lille tekstfil, som gemmes på din computer, når du besøger et website. Vi bruger cookies til en række formål, og for at forbedre din oplevelse på vores website (eksempelvis for at huske dine login oplysninger).","pc_yprivacy_text_3":"Du kan ændre dine indstillinger og afvise forskellige typer cookies, som gemmes på din computer, når du besøger vores website. Du kan også fjerne cookies som allerede er gemt på din computer, men bemærk venligst at sletning af cookies kan betyde der er dele af hjemmesiden som ikke virker.","pc_yprivacy_title":"Dit privatliv","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Fortrolighedspolitik</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Active","always_active":"Întotdeauna active","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inactive","nb_agree":"Sunt de acord","nb_changep":"Vreau să schimb setările","nb_ok":"OK","nb_reject":"Refuz","nb_text":"Folosim cookie-uri și alte tehnologii de urmărire pentru a îmbunătăți experiența ta de navigare pe website-ul nostru, pentru afișa conținut și reclame personalizate, pentru a analiza traficul de pe website-ul nostru și pentru a înțelege de unde vin vizitatorii noștri.","nb_title":"Folosim cookie-uri","pc_fnct_text_1":"Cookie-uri funcționale","pc_fnct_text_2":"Aceste cookie-uri sunt folosite pentru a-ți asigura o experiență personalizată pe website-ul nostru și pentru salvarea alegerilor pe care le faci când folosești website-ul nostru.","pc_fnct_text_3":"De exemplu, putem folosi cookie-uri funcționale pentru a salva preferințele tale legate de limba website-ului nostru sau datele de logare.","pc_minfo_text_1":"Mai multe informații","pc_minfo_text_2":"Pentru mai multe informații cu privire la politica noastră de cookie-uri și preferințele tale, te rugăm să ne contactezi.","pc_minfo_text_3":"Pentru a afla mai multe, te rugăm să citești <a href=\'%s\' target=\'_blank\'>Politica noastră de confidențialitate</a>.","pc_save":"Salvează","pc_sncssr_text_1":"Cookie-uri strict necesare","pc_sncssr_text_2":"Aceste cookie-uri sunt esențiale pentru a putea beneficia de serviciile disponibile pe website-ul nostru.","pc_sncssr_text_3":"Fără aceste cookie-uri nu poți folosi anumite funcționalități ale website-ului nostru.","pc_title":"Preferințe pentru Cookie-uri","pc_trck_text_1":"Cookie-uri de analiză și performanță","pc_trck_text_2":"Acest tip de cookie-uri sunt folosite pentru a colecta informații în vederea analizării traficului pe website-ul nostru și modul în care vizitatorii noștri folosesc website-ul.","pc_trck_text_3":"De exemplu, aceste cookie-uri pot urmări cât timp petreci pe website sau paginile pe care le vizitezi, ceea ce ne ajută să înțelegem cum putem îmbunătăți website-ul pentru tine.","pc_trck_text_4":"Informațiile astfel colectate nu identifică individual vizitatorii.","pc_trgt_text_1":"Cookie-uri pentru marketing și publicitate","pc_trgt_text_2":"Aceste cookie-uri sunt folosite pentru a-ți afișa reclame cât mai pe interesul tău, în funcție de obiceiurile tale de navigare.","pc_trgt_text_3":"Aceste cookie-uri, așa cum sunt afișate de furnizori noștri de conținut și/sau publicitate, pot combina informații de pe website-ul nostru cu alte informații pe care furnizori noștri le-au colectat în mod independent cu privire la activitatea ta în rețeaua lor de website-uri.","pc_trgt_text_4":"Dacă alegi să ștergi sau să dezactivezi aceste cookie-uri tot vei vedea reclame, dar se poate ca aceste reclame să nu fie relevante pentru tine.","pc_yprivacy_text_1":"Confidențialitatea ta este importantă pentru noi","pc_yprivacy_text_2":"Cookie-urile sunt fișiere text foarte mici ce sunt salvate în browser-ul tău atunci când vizitezi un website. Folosim cookie-uri pentru mai multe scopuri, dar și pentru a îți oferi cea mai bună experiență de utilizare posibilă (de exemplu, să reținem datele tale de logare în cont).","pc_yprivacy_text_3":"Îți poți modifica preferințele și poți refuza ca anumite tipuri de cookie-uri să nu fie salvate în browser în timp ce navigezi pe website-ul nostru. Deasemenea poți șterge cookie-urile salvate deja în browser, dar reține că este posibil să nu poți folosi anumite părți ale website-ul nostru în acest caz.","pc_yprivacy_title":"Confidențialitatea ta","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Politica noastră de confidențialitate</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktívne","always_active":"Vždy aktívne","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktívne","nb_agree":"Súhlasím","nb_changep":"Zmeniť moje nastavenia","nb_ok":"OK","nb_reject":"Odmietam","nb_text":"Súbory cookie a ďalšie technológie sledovania používame na zlepšenie vášho zážitku z prehliadania našich webových stránok, na to, aby sme vám zobrazovali prispôsobený obsah a cielené reklamy, na analýzu návštevnosti našich webových stránok a na pochopenie toho, odkiaľ naši návštevníci prichádzajú.","nb_title":"Používame cookies","pc_fnct_text_1":"Funkčné cookies","pc_fnct_text_2":"Tieto súbory cookie sa používajú na to, aby vám poskytli osobnejšie prostredie na našej webovej stránke, a na zapamätanie si rozhodnutí, ktoré urobíte pri používaní našej webovej stránky.","pc_fnct_text_3":"Napríklad môžeme použiť funkčné cookies na zapamätanie vašich jazykových preferencií alebo na zapamätanie vašich prihlasovacích údajov.","pc_minfo_text_1":"Viac informácií","pc_minfo_text_2":"Ak máte akékoľvek otázky týkajúce sa našich zásad týkajúcich sa súborov cookie a vašich možností, kontaktujte nás.","pc_minfo_text_3":"Ak sa chcete dozvedieť viac, navštívte <a href=\'%s\' target=\'_blank\'>Zásady ochrany osobných údajov</a>.","pc_save":"Ulož moje predvoľby","pc_sncssr_text_1":"Nevyhnutne potrebné cookies","pc_sncssr_text_2":"Tieto súbory cookie sú nevyhnutné na to, aby sme vám mohli poskytovať služby dostupné prostredníctvom našej webovej stránky a aby ste mohli používať určité funkcie našej webovej stránky.","pc_sncssr_text_3":"Bez týchto súborov cookie vám nemôžeme poskytnúť určité služby na našom webe.","pc_title":"Centrum predvolieb cookies","pc_trck_text_1":"Sledovacie a výkonnostné cookies","pc_trck_text_2":"Tieto súbory cookie sa používajú na zhromažďovanie informácií na analýzu prenosu na našom webe a toho, ako návštevníci používajú náš web.","pc_trck_text_3":"Tieto súbory cookie môžu napríklad sledovať napríklad to, koľko času strávite na webových stránkach alebo navštívených stránkach, čo nám pomáha pochopiť, ako môžeme pre vás vylepšiť naše webové stránky.","pc_trck_text_4":"Informácie zhromaždené prostredníctvom týchto súborov cookie na sledovanie a výkonnosť neidentifikujú žiadneho jednotlivého návštevníka.","pc_trgt_text_1":"Zacielenie a reklamné cookies","pc_trgt_text_2":"Tieto súbory cookie sa používajú na zobrazovanie reklám, ktoré by vás mohli pravdepodobne zaujímať na základe vašich zvykov pri prehliadaní.","pc_trgt_text_3":"Tieto súbory cookie, ktoré slúžia pre náš obsah a/alebo poskytovateľov reklám, môžu kombinovať informácie zhromaždené z našej webovej stránky s ďalšími informáciami, ktoré nezávisle zhromaždili, týkajúce sa aktivít vášho webového prehliadača v rámci ich siete webových stránok.","pc_trgt_text_4":"Ak sa rozhodnete odstrániť alebo zakázať tieto súbory cookie pre zacielenie alebo reklamu, stále sa vám budú zobrazovať reklamy, ktoré však pre vás nemusia byť relevantné.","pc_yprivacy_text_1":"Vaše súkromie je pre nás dôležité","pc_yprivacy_text_2":"Súbory cookie sú veľmi malé textové súbory, ktoré sa ukladajú do vášho počítača pri návšteve webovej stránky. Súbory cookie používame na rôzne účely a na zlepšenie vášho online zážitku z našej webovej stránky (napríklad na zapamätanie prihlasovacích údajov vášho účtu).","pc_yprivacy_text_3":"Môžete zmeniť svoje predvoľby a odmietnuť určité typy súborov cookie, ktoré sa majú ukladať vo vašom počítači pri prehliadaní našich webových stránok. Môžete tiež odstrániť všetky súbory cookie, ktoré sú už uložené vo vašom počítači, ale nezabudnite, že vymazanie súborov cookie vám môže zabrániť v používaní častí našej webovej stránky.","pc_yprivacy_title":"Vaše súkromie","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Zásady ochrany osobných údajov</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktivni","always_active":"Vedno aktivni","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktivni","nb_agree":"Se strinjam","nb_changep":"Spremeni moje nastavitve","nb_ok":"V redu","nb_reject":"Zavračam","nb_text":"Piškotke in druge sledilne tehnologije uporabljamo za izboljšanje vaše uporabniške izkušnje med brskanjem po naši spletni strani, za  prikazovanje personaliziranih vsebin oz. targetiranih oglasov, za analizo obiskov naše spletne strani in za vpogled v to, iz kje prihajajo naši gostje.","nb_title":"Uporabljamo piškotke","pc_fnct_text_1":"Funkcionalni piškotki (ang. functionality cookies)","pc_fnct_text_2":"Ti piškotki se uporabljajo za zagotavljanje bolj personalizirane izkušnje na naši spletni strani in za shranjevanje vaših odločitev ob uporabi naše spletne strani.","pc_fnct_text_3":"Funkcionalne piškotke lahko, na primer, uporabljamo za to, da si zapomnimo vaše jezikovne nastavitve oz. podatke za vpis v vaš račun.","pc_minfo_text_1":"Več informacij","pc_minfo_text_2":"Če imate kakršnakoli vprašanja v zvezi z našim pravilnikom o piškotkih in vaših izbirah, nas prosim kontaktirajte.","pc_minfo_text_3":"Za več informacij si prosim oglejte naš <a href=\'%s\' target=\'_blank\'>Politika zasebnosti</a>.","pc_save":"Shrani moje nastavitve","pc_sncssr_text_1":"Nujno potrebni piškotki (ang. strictly necessary cookies)","pc_sncssr_text_2":"Ti piškotki so ključnega pomena pri zagotavljanju storitev, ki so na voljo na naši spletni strani, in pri omogočanju določenih funkcionalnosti naše spletne strani.","pc_sncssr_text_3":"Brez teh piškotkov vam ne moremo zagotoviti določenih storitev na naši spletni strani.","pc_title":"Nastavitve piškotkov","pc_trck_text_1":"Sledilni in izvedbeni piškotki (ang. tracking and performance cookies)","pc_trck_text_2":"Ti piškotki se uporabljajo za zbiranje podatkov za analizo obiskov naše spletne strani in vpogled v to, kako gostje uporabljajo našo spletno stran.","pc_trck_text_3":"Ti piškotki lahko, na primer, spremljajo stvari kot so to, koliko časa preživite na naši spletni strani oz. katere strani obiščete, kar nam pomaga pri razumevanju, kako lahko za vas izboljšamo spletno stran.","pc_trck_text_4":"Podatki, ki jih zbirajo ti piškotki, ne identificirajo nobenega posameznega uporabnika.","pc_trgt_text_1":"Ciljni in oglaševalski piškotki (ang. targeting and advertising cookies)","pc_trgt_text_2":"Ti piškotki se uporabljajo za prikazovanje spletnih oglasov, ki vas bodo na podlagi vaših navad pri brskanju verjetno zanimali.","pc_trgt_text_3":"Ti piškotki, ki jih uporabljajo naši oglaševalski ponudniki oz. ponudniki vsebine, lahko združujejo podatke, ki so jih zbrali na naši spletni strani, z drugimi podatki, ki so jih zbrali neodvisno v povezavi z dejavnostmi vašega spletnega brskalnika na njihovi mreži spletnih mest.","pc_trgt_text_4":"Če se odločite izbrisati oz. onemogočiti te ciljne in oglaševalske piškotke, boste še vedno videvali oglase, vendar ti morda ne bodo relevantni za vas.","pc_yprivacy_text_1":"Cenimo vašo zasebnost","pc_yprivacy_text_2":"Piškotki so majhne besedilne datoteke, ki se shranijo na vašo napravo ob obisku spletne strani. Piškotke uporabljamo v več namenov, predvsem pa za izboljšanje vaše spletne izkušnje na naši strani (na primer za shranjevanje podatkov ob vpisu v vaš račun).","pc_yprivacy_text_3":"Vaše nastavitve lahko spremenite in onemogočite določenim vrstam piškotkov, da bi se shranili na vašo napravo med brskanjem po naši spletni strani. Poleg tega lahko odstranite katerekoli piškotke, ki so že shranjeni v vaši napravi, a upoštevajte, da vam bo po izbrisu piškotkov morda onemogočeno uporabljati dele naše spletne strani.","pc_yprivacy_title":"Vaša zasebnost","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Politika zasebnosti</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktywne","always_active":"Zawsze aktywne","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Nieaktywne","nb_agree":"Zgoda","nb_changep":"Zmiana ustawień","nb_ok":"OK","nb_reject":"Odmawiam","nb_text":"Używamy plików cookie i innych technologii śledzenia, aby poprawić jakość przeglądania naszej witryny, wyświetlać spersonalizowane treści i reklamy, analizować ruch w naszej witrynie i wiedzieć, skąd pochodzą nasi użytkownicy.","nb_title":"Używamy pliki cookie","pc_fnct_text_1":"Funkcjonalne","pc_fnct_text_2":"Te pliki cookie służą do bardziej spersonalizowanego korzystania z naszej strony internetowej i do zapamiętywania wyborów dokonywanych podczas korzystania z naszej strony internetowej.","pc_fnct_text_3":"Na przykład możemy używać funkcjonalnych plików cookie do zapamiętywania preferencji językowych lub zapamiętywania danych logowania.","pc_minfo_text_1":"Więcej informacji","pc_minfo_text_2":"W przypadku jakichkolwiek pytań dotyczących naszej polityki dotyczącej plików cookie i Twoich wyborów, skontaktuj się z nami.","pc_minfo_text_3":"Aby dowiedzieć się więcej, odwiedź naszą <a href=\'%s\' target=\'_blank\'>Polityka prywatności</a>.","pc_save":"Zapisz ustawienia","pc_sncssr_text_1":"Niezbędne","pc_sncssr_text_2":"Te pliki cookie są niezbędne do świadczenia usług dostępnych za pośrednictwem naszej strony internetowej i umożliwienia korzystania z niektórych funkcji naszej strony internetowej.","pc_sncssr_text_3":"Bez tych plików cookie nie możemy zapewnić usług na naszej stronie internetowej.","pc_title":"Centrum ustawień cookie","pc_trck_text_1":"Śledzenie i wydajność","pc_trck_text_2":"Te pliki cookie służą do zbierania informacji w celu analizy ruchu na naszej stronie internetowej i sposobu, w jaki użytkownicy korzystają z naszej strony internetowej.","pc_trck_text_3":"Na przykład te pliki cookie mogą śledzić takie rzeczy, jak czas spędzony na stronie lub odwiedzane strony, co pomaga nam zrozumieć, w jaki sposób możemy ulepszyć naszą witrynę internetową.","pc_trck_text_4":"Informacje zebrane przez te pliki nie identyfikują żadnego konkretnego użytkownika.","pc_trgt_text_1":"Targeting i reklama","pc_trgt_text_2":"Te pliki cookie służą do wyświetlania reklam, które mogą Cię zainteresować na podstawie Twoich zwyczajów przeglądania.","pc_trgt_text_3":"Pliki te tworzone przez naszych dostawców treści i/lub reklam, mogą łączyć informacje zebrane z naszej strony z innymi informacjami, które gromadzili niezależnie w związku z działaniami przeglądarki internetowej w ich sieci witryn.","pc_trgt_text_4":"Jeśli zdecydujesz się usunąć lub wyłączyć te pliki cookie, reklamy nadal będą wyświetlane, ale mogą one nie być odpowiednie dla Ciebie.","pc_yprivacy_text_1":"Twoja prywatność jest dla nas ważna","pc_yprivacy_text_2":"Pliki cookie to bardzo małe pliki tekstowe, które są tworzone i przechowywane na komputerze użytkownika podczas odwiedzania strony internetowej. Używamy plików cookie do różnych celów, w tym do ulepszania obsługi online na naszej stronie internetowej (na przykład, aby zapamiętać dane logowania do konta).","pc_yprivacy_text_3":"Możesz zmienić swoje ustawienia i odrzucić niektóre rodzaje plików cookie, które mają być przechowywane na twoim komputerze podczas przeglądania naszej strony. Możesz również usunąć wszystkie pliki cookie już zapisane na komputerze, ale pamiętaj, że usunięcie plików cookie może uniemożliwić korzystanie z części naszej strony internetowej.","pc_yprivacy_title":"Twoja prywatność","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Polityka prywatności</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktivno","always_active":"Uvek aktivno","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktivno","nb_agree":"Slažem se","nb_changep":"Promeni moja podešavanja","nb_ok":"OK","nb_reject":"Odbijam","nb_text":"Mi koristimo kolačiće i ostale tehnologije za praćenje kako bismo unapredili vašu pretragu na našem veb sajtu, prikazali personalizovani sadržaj i ciljane reklame, analizirali posete na našem sajtu i razumeli odakle dolaze naši posetioci sajta.","nb_title":"Mi koristimo kolačiće","pc_fnct_text_1":"Funkcionalni kukiji","pc_fnct_text_2":"Ovi kukiji koriste se za pružanje personalizovanijeg iskustva na našem veb sajtu i za pamćenje izbora koje koristite kada koristite našu veb sajt.","pc_fnct_text_3":"Na primer, možemo da koristimo kukije funkcionalnosti da bismo zapamtili vaše jezičke postavke ili upamtili vaše podatke za prijavu.","pc_minfo_text_1":"Više informacija","pc_minfo_text_2":"Za bilo koje upite vezane za našu politiku o kukijima i vašim izbor, molimo vas kontaktirajte nas.","pc_minfo_text_3":"Da saznate više, pogledajte našu <a href=\'%s\' target=\'_blank\'>Pravila o privatnosti</a>.","pc_save":"Sačuvaj moja podešavanja","pc_sncssr_text_1":"Obavezni kukiji","pc_sncssr_text_2":"Ovi kukiji su neophodni za pružanje usluga dostupnih putem našeg veb sajta i za omogućavanje korišćenja određenih funkcija našeg veb sajta.","pc_sncssr_text_3":"Bez ovih kolačića ne možemo vam pružiti određene usluge na našem veb sajtu.","pc_title":"Centar za podešavanje kolačić","pc_trck_text_1":"Praćenje i performanse kolačić","pc_trck_text_2":"Ovi kukiji koriste se za prikupljanje informacija za analizu saobraćaja na našem veb sajtu i kako posetioci koriste naš veb sajt.","pc_trck_text_3":"Na primer, ovi kolačići mogu pratiti stvari poput vremena koliko provodite na veb lokaciji ili stranicama koje posećujete što nam pomaže da shvatimo kako možemo da poboljšamo naš veb sajt.","pc_trck_text_4":"Informacije prikupljene ovim kukijima za praćenje i performanse ne identifikuju nijednog pojedinačnog posetioca.","pc_trgt_text_1":"Ciljanje i oglašavanje kolačić","pc_trgt_text_2":"Ovi kukiji koriste se za prikazivanje reklama koje će vas verovatno zanimati na osnovu vaših navika pregledavanja.","pc_trgt_text_3":"Ovi kukiji, opsluženi od strane naših dobavljača sadržaja i / ili oglašavanja, mogu kombinovati informacije koje su sakupili sa našeg veb sajta sa drugim informacijama koje su nezavisno prikupili u vezi sa aktivnostima vašeg veb pretraživača kroz mrežu njihovih veb sajtova.","pc_trgt_text_4":"Ako odlučite da uklonite ili onemogućite ove ciljane ili reklamne kukije i dalje ćete videti oglase, ali oni možda neće biti relevantni za vas.","pc_yprivacy_text_1":"Vaša privatnost je važna za nas","pc_yprivacy_text_2":"Kukiji su veoma mali tekstualni fajlovi koji su sačuvani na vašem računaru kada posećujete veb sajt. Mi koristimo kolačiće za različite namene i kako bi unapredili vaše onlajn iskustvo na našem veb sajtu (na primer, kako bi zapamtili vaše pristupne podatke).","pc_yprivacy_text_3":"Vi možete promeniti vaša podešavanja i odbiti određenu vrstu kolačića koji će biti sačuvani na vašem računaru dok pregledate naš veb sajt. Takođe možete izbisati bilo koji kuki koji je već sačuvan u vašem računaru, ali imajte na umu da brisanjem kolačić možete onemogućiti pristup nekim delovima našeg veb sajta.","pc_yprivacy_title":"Vaša privatnost","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Pravila o privatnosti</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Įjungta","always_active":"Visada įjungta","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Išjungta","nb_agree":"Sutinku","nb_changep":"Keisti mano pasirinkimus","nb_ok":"Gerai","nb_reject":"Aš atsisakau","nb_text":"Mes naudojame slapukus ir kitas stebėjimo technologijas, siekdami pagerinti jūsų naršymo mūsų svetainėje patirtį, parodyti jums pritaikytą turinį ir tikslinius skelbimus, išanalizuoti mūsų svetainės srautą ir suprasti, iš kur ateina mūsų lankytojai.","nb_title":"Mes naudojame slapukus","pc_fnct_text_1":"Funkcionalumo slapukai","pc_fnct_text_2":"Šie slapukai naudojami siekiant suteikti jums asmeniškesnę patirtį mūsų svetainėje ir prisiminti pasirinkimus, kuriuos atlikote, kai naudojatės mūsų svetaine.","pc_fnct_text_3":"Pvz., Mes galime naudoti funkcinius slapukus, kad prisimintume jūsų kalbos nustatymus arba prisimintume jūsų prisijungimo duomenis.","pc_minfo_text_1":"Daugiau informacijos","pc_minfo_text_2":"Dėl bet kokių klausimų, susijusių su mūsų slapukų politika ir jūsų pasirinkimais, susisiekite su mumis.","pc_minfo_text_3":"Norėdami sužinoti daugiau, susipažinkite su mūsų <a href=\'%s\' target=\'_blank\'>Privatumo politika</a>.","pc_save":"Išsaugoti mano pasirinkimus","pc_sncssr_text_1":"Privalomi slapukai","pc_sncssr_text_2":"Šie slapukai yra būtini norint suteikti jums paslaugas, pasiekiamas mūsų svetainėje, ir leisti naudotis tam tikromis mūsų svetainės funkcijomis.","pc_sncssr_text_3":"Be šių slapukų mes negalime jums suteikti tam tikrų paslaugų mūsų svetainėje.","pc_title":"Slapukų Pasirinkimo Centras","pc_trck_text_1":"Stebėjimo ir našumo slapukai","pc_trck_text_2":"Šie slapukai naudojami rinkti informaciją, siekiant analizuoti srautą į mūsų svetainę ir tai, kaip lankytojai naudojasi mūsų svetaine.","pc_trck_text_3":"Pavyzdžiui, šie slapukai gali sekti kiek laiko praleidžiate svetainėje ar lankomuose puslapiuose, o tai padeda mums suprasti, kaip galime patobulinti savo svetainę.","pc_trck_text_4":"Informacija, surinkta naudojant šiuos stebėjimo ir našumo slapukus, neatpažįsta konkretaus lankytojo.","pc_trgt_text_1":"Tiksliniai ir reklaminiai slapukai","pc_trgt_text_2":"Šie slapukai naudojami rodyti reklamą, kuri greičiausiai jus domina, atsižvelgiant į jūsų naršymo įpročius.","pc_trgt_text_3":"Šie slapukai, kuriuos teikia mūsų turinio ir (arba) reklamos teikėjai, gali apjungti informaciją, kurią jie surinko iš mūsų svetainės, su kita informacija, kurią jie rinko nepriklausomai, apie jūsų interneto naršyklės veiklą jų svetainių tinkle.","pc_trgt_text_4":"Jei nuspręsite pašalinti arba išjungti šiuos tikslinius ar reklamavimo slapukus, vis tiek pamatysite skelbimus, tačiau jie gali būti jums neaktualūs.","pc_yprivacy_text_1":"Mums rūpi jūsų privatumas","pc_yprivacy_text_2":"Slapukai yra labai maži tekstiniai failai, kurie saugomi jūsų kompiuteryje, kai apsilankote svetainėje. Mes naudojame slapukus įvairiais tikslais ir siekdami pagerinti jūsų internetinę patirtį mūsų svetainėje (pavyzdžiui, jei norite, kad būtu įsimenami jūsų prisijungimo duomenys).","pc_yprivacy_text_3":"Naršydami mūsų svetainėje galite pakeisti savo nustatymus ir atsisakyti tam tikrų tipų slapukų, kurie bus saugomi jūsų kompiuteryje. Taip pat galite pašalinti visus slapukus, jau saugomus jūsų kompiuteryje, tačiau nepamirškite, kad ištrynę slapukus galite nepilnai naudotis mūsų svetaine.","pc_yprivacy_title":"Jūsų privatumas","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Privatumo politika</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktīvs","always_active":"Vienmēr aktīvs","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Neaktīvs","nb_agree":"Es piekrītu","nb_changep":"Mainīt manas preferences","nb_ok":"OK","nb_reject":"Es noraidu","nb_text":"Mēs izmantojam sīkdatnes un citas izsekošanas tehnoloģijas, lai uzlabotu Jūsu pārlūkošanas pieredzi mūsu vietnē, parādītu Jums personalizētu saturu un mērķētas reklāmas, analizētu mūsu vietnes datplūsmu un saprastu, no kurienes nāk mūsu apmeklētāji.","nb_title":"Mēs izmantojam sīkdatnes","pc_fnct_text_1":"Funkcionalitātes sīkdatnes","pc_fnct_text_2":"Šīs sīkdatnes tiek izmantotas, lai Jūs nodrošinātu ar personalizētu pieredzi mūsu mājaslapā un lai atcerētos izvēles, kuras veicat izmantojot mūsu mājaslapu.","pc_fnct_text_3":"Piemēram, mēs varam izmantot funkcionalitātes sīkdatnes, lai atcerētos Jūsu valodas preferences vai konta pieteikšanās datus.","pc_minfo_text_1":"Vairāk informācijas","pc_minfo_text_2":"Par jautājumiem saistītiem ar mūsu sīkdatņu politiku un Jūsu izvēlēm, lūdzu, sazinieties ar mums.","pc_minfo_text_3":"Lai uzzinātu vairāk, lūdzu apmeklējiet mūsu <a href=\'%s\' target=\'_blank\'>Privacy Policy</a>.","pc_save":"Saglabāt manas preferences","pc_sncssr_text_1":"Strikti nepieciešamās sīkdatnes","pc_sncssr_text_2":"Šīs sīkdatnes ir nepieciešamas, lai nodrošinātu Jums pakalpojumus, kas pieejami caur mūsu mājaslapu un ļautu Jums izmantot noteiktas mūsu vietnes funkcijas.","pc_sncssr_text_3":"Bez šīm sīkdatnēm, mēs nevaram Jums nodrošināt noteiktus pakalpojumus mūsu mājaslapā.","pc_title":"Sīkdatņu Preferenču Centrs","pc_trck_text_1":"Izsekošanas sīkdatnes","pc_trck_text_2":"Šīs sīkdatnes tiek izmantotas informācijas apkopošanai, lai analizētu mūsu mājaslapas datplūsmu, un kā apmeklētāji izmanto mūsu mājaslapu.","pc_trck_text_3":"Piemēram, šīs sīkdatnes var izsekot cik daudz laika Jūs pavadāt mājaslapā vai Jūsu apmeklētās lapas, kas mums palīdz saprast, kā mēs Jums varam uzlabot mūsu mājaslapu.","pc_trck_text_4":"Informācija, kas savākta, izmantojot šīs izsekošanas un veiktspējas sīkdatnes, neidentificē nevienu atsevišķu apmeklētāju.","pc_trgt_text_1":"Mērķauditorijas atlases un reklāmas sīkdatnes","pc_trgt_text_2":"Šīs sīkdatnes tiek izmantotas, lai rādītu reklāmas, kas iespējams, Jūs interesēs, pamatojoties uz Jūsu pārlūkošanas paradumiem.","pc_trgt_text_3":"Šīs sīkdatnes, ko apkalpo mūsu satura un/vai reklāmas nodrošinātāji, var apvienot informāciju , kas savākta no mūsu mājaslapas ar citu viņu rīcībā esošo informāciju, ko viņi ir neatkarīgi apkopojuši, kas saistīta ar Jūsu tīmekļa pārlūkprogrammas darbību viņu vietņu tīklā.","pc_trgt_text_4":"Ja Jūs izvēlaties noņemt vai atspējot šīs mērķauditorijas atlases vai reklāmas sīkdatnes, Jūs joprojām redzēsiet reklāmas, bet tās var nebūt Jums aktuālas.","pc_yprivacy_text_1":"Mums ir svarīgs Jūsu privātums","pc_yprivacy_text_2":"Sīkdatnes ir ļoti mazi teksta faili, kas tiek saglabāti Jūsu datorā, kad apmeklējat mājaslapu. Mēs izmantojam sīkdatnes dažādiem mērķiem, un lai uzlabotu Jūsu tiešsaistes pieredzi mūsu mājaslapā (piemēram, lai atcerētos Jūsu konta pieteikšanās datus).","pc_yprivacy_text_3":"Jūs varat mainīt savas preferences un noraidīt noteiktus sīkfailu veidus, kas saglabātos Jūsu datorā, pārlūkojot mūsu mājaslapu. Jūs varat arī noņemt sīkfailus, kas jau ir saglabāti Jūsu datorā, taču paturiet prātā, ka sīkdatņu dzēšana var liegt Jums izmantot atsevišķas daļas no mūsu mājaslapas.","pc_yprivacy_title":"Jūsu privātums","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Privacy Policy</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Активно","always_active":"Всегда активно","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Неактивно","nb_agree":"Я согласен","nb_changep":"Изменить мои предпочтения","nb_ok":"Ок","nb_reject":"Я отказываюсь","nb_text":"Мы используем файлы куки и другие технологии отслеживания для улучшения вашего просмотра на нашем веб-сайте, чтобы показывать вам персонализированный контент и таргетированную рекламу, анализировать трафик нашего веб-сайта и понимать, откуда приходят наши посетители.","nb_title":"Мы используем куки","pc_fnct_text_1":"Функциональные куки","pc_fnct_text_2":"Файлы куки используются, чтобы предоставить вам более персонализированный опыт на нашем веб-сайте и запомнить выбор, который вы делаете при использовании нашего веб-сайта.","pc_fnct_text_3":"Например, мы можем использовать функциональные файлы куки, чтобы запомнить ваши языковые предпочтения или данные для входа.","pc_minfo_text_1":"Больше информации.","pc_minfo_text_2":"По любым вопросам, касающимся нашей политики в отношении файлов куки и вашего выбора, свяжитесь с нами.","pc_minfo_text_3":"Чтобы узнать больше, посетите наш сайт <a href=\'%s\' target=\'_blank\'>Privacy Policy</a>.","pc_save":"Сохранить мои предпочтения","pc_sncssr_text_1":"Необходимые куки","pc_sncssr_text_2":"Файлы куки необходимы для предоставления вам услуг, доступных через наш веб-сайт, и для того, чтобы вы могли использовать определенные функции нашего веб-сайта.","pc_sncssr_text_3":"Без этих файлов куки мы не можем предоставлять вам определенные функции на нашем веб-сайте.","pc_title":"Центр настроек файлов куки","pc_trck_text_1":"Отслеживание куки","pc_trck_text_2":"Файлы куки используются для сбора информации для анализа трафика на наш веб-сайт и того, как посетители используют наш веб-сайт.","pc_trck_text_3":"Например, эти файлы куки могут отслеживать такие вещи, как время, которое вы проводите на веб-сайте или посещаемые вами страницы, что помогает нам понять, как мы можем улучшить наш веб-сайт для вас.","pc_trck_text_4":"Информация, собранная с помощью файлов куки для отслеживания и производительности, не идентифицирует отдельного посетителя.","pc_trgt_text_1":"Целевые и рекламные файлы куки","pc_trgt_text_2":"Эти файлы куки используются для показа рекламы, которая может быть вам интересна в зависимости от ваших привычек просмотра.","pc_trgt_text_3":"Эти файлы куки, обслуживаемые нашими поставщиками контента и / или рекламы, могут объединять информацию, собранную ими с нашего веб-сайта, с другой информацией, которую они независимо собирали относительно действий вашего браузера в их сети веб-сайтов.","pc_trgt_text_4":"Если вы решите удалить или отключить эти целевые или рекламные файлы куки, вы все равно будете видеть рекламу, но она может не иметь отношения к вам.","pc_yprivacy_text_1":"Ваша конфиденциальность важна для нас","pc_yprivacy_text_2":"Куки - это небольшие текстовые файлы, которые сохраняются на вашем компьютере, когда Вы посещаете веб-сайт. Мы используем куки для различных целей, в том числе для того, чтобы улучшить ваше пребывание на нашем веб-сайте (например, чтобы запомнить данные для входа в вашу учетную запись).","pc_yprivacy_text_3":"Вы можете изменить свои предпочтения и отказаться от сохранения определенных типов файлов cookie на вашем компьютере во время просмотра нашего веб-сайта. Вы также можете удалить любые файлы куки, уже хранящиеся на вашем компьютере, но имейте в виду, что удаление файлов cookie может помешать вам использовать некоторые части нашего веб-сайта.","pc_yprivacy_title":"Ваша конфиденциальность","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Privacy Policy</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Aktiv","always_active":"Alltid aktiv","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Inaktiv","nb_agree":"Godta alle","nb_changep":"Endre innstillinger","nb_ok":"OK","nb_reject":"Avvis alle","nb_text":"Vi bruker informasjonskapsler og andre sporingsteknologier for å forbedre din nettleseropplevelse på nettstedet vårt, for å vise deg personlig tilpasset innhold og målrettede annonser, for å analysere nettstedstrafikken vår og for å forstå hvor våre besøkende kommer fra.","nb_title":"Vi bruker informasjonskapsler","pc_fnct_text_1":"Funksjonalitetscookies","pc_fnct_text_2":"Disse informasjonskapslene brukes til å gi deg en mer personlig opplevelse på nettstedet vårt og til å huske valg du tar når du bruker nettstedet vårt.","pc_fnct_text_3":"For eksempel kan vi bruke funksjonalitetscookies for å huske språkinnstillingene dine eller huske påloggingsinformasjonen din.","pc_minfo_text_1":"Mer informasjon","pc_minfo_text_2":"For spørsmål angående våre retningslinjer for informasjonskapsler og dine valg, vennligst kontakt oss.","pc_minfo_text_3":"For å finne ut mer, besøk vår <a href=\'%s\' target=\'_blank\'>personvernpolicy</a>.","pc_save":"Lagre mine preferanser","pc_sncssr_text_1":"Strengt nødvendige informasjonskapsler","pc_sncssr_text_2":"Disse informasjonskapslene er viktige for å gi deg tjenester tilgjengelig via nettstedet vårt og for å gjøre det mulig for deg å bruke visse funksjoner på nettstedet vårt.","pc_sncssr_text_3":"Uten disse informasjonskapslene kan vi ikke tilby deg visse tjenester på nettstedet vårt.","pc_title":"Informasjonssenter for informasjonskapsler","pc_trck_text_1":"Sporings- og ytelses-informasjonskapsler","pc_trck_text_2":"Disse informasjonskapslene brukes til å samle inn informasjon for å analysere trafikken til nettstedet vårt og hvordan besøkende bruker nettstedet vårt","pc_trck_text_3":"Disse informasjonskapslene kan for eksempel spore ting som hvor lang tid du bruker på nettstedet eller sidene du besøker, noe som hjelper oss å forstå hvordan vi kan forbedre nettstedet vårt for deg.","pc_trck_text_4":"Informasjonen som samles inn gjennom disse sporings- og ytelseskapslene, identifiserer ikke noen individuell besøkende.","pc_trgt_text_1":"Målretting og annonsering av informasjonskapsler","pc_trgt_text_2":"Disse informasjonskapslene brukes til å vise reklame som sannsynligvis vil være av interesse for deg basert på nettleservaner.","pc_trgt_text_3":"Disse informasjonskapslene, som serveres av innholds- og / eller reklameleverandører, kan kombinere informasjon de har samlet inn fra nettstedet vårt med annen informasjon de har samlet uavhengig av nettleserens aktiviteter på tvers av nettverket av nettsteder.","pc_trgt_text_4":"Hvis du velger å fjerne eller deaktivere disse målrettings- eller annonseringskapslene, vil du fremdeles se annonser, men de er kanskje ikke relevante for deg.","pc_yprivacy_text_1":"Ditt personvern er viktig for oss","pc_yprivacy_text_2":"Informasjonskapsler er veldig små tekstfiler som lagres på datamaskinen din når du besøker et nettsted. Vi bruker informasjonskapsler for en rekke formål og for å forbedre din online opplevelse på nettstedet vårt (for eksempel for å huske påloggingsinformasjonen din).","pc_yprivacy_text_3":"Du kan endre innstillingene dine og avvise visse typer informasjonskapsler som skal lagres på datamaskinen din mens du surfer på nettstedet vårt. Du kan også fjerne alle informasjonskapsler som allerede er lagret på datamaskinen din, men husk at sletting av informasjonskapsler kan forhindre deg i å bruke deler av nettstedet vårt.","pc_yprivacy_title":"Ditt personvern","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Personvernpolicy</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"В действие са бисквитките","always_active":"Винаги в действие са бисквитките","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Неактивни бисквитки","nb_agree":"Съгласен съм","nb_changep":"Промяна на предпочитанията ми","nb_ok":"Добре","nb_reject":"Аз отказвам","nb_text":"Ние използваме бисквитки и други, проследяващи, технологии, за да подобрим сърфирането ви в нашия сайт, като ви покажем персонализирано съдържание и реклами, да анализираме трафика на нашия сайт и да разберем откъде идват нашите посетители.","nb_title":"Ние използваме бисквитки","pc_fnct_text_1":"Функционални бисквитки","pc_fnct_text_2":"Тези бисквитки се използват, за да ви осигурят още по-персонализирано изживяване на нашия уебсайт и да бъдат запомнени изборите, които сте направили, когато използвахте нашия уебсайт.","pc_fnct_text_3":"Например: може да използваме функционални бисквитки, за да запомним предпочитания ви език или да запомним детайли по влизането ви в уебсайта.","pc_minfo_text_1":"Още информация","pc_minfo_text_2":"За всякакви въпроси във връзка с нашата политика за бисквитките и вашите избори, моля, свържете се с нас.","pc_minfo_text_3":"За да научите повече, моля, посетете нашата <a href=\'%s\' target=\'_blank\'>Страница за поверителност</a>.","pc_save":"Запази предпочитанията ми","pc_sncssr_text_1":"Строго задължителни бисквитки","pc_sncssr_text_2":"Тези бисквитки са съществен елемент, който осигурява услуги, достъпни чрез нашия уебсайт и дават възможност за използване на определени функции на нашия уебсайт.","pc_sncssr_text_3":"Без тези бисквитки не можем да ви доставим определени услуги на нашия уебсайт.","pc_title":"Център за настройка на бисквитки","pc_trck_text_1":"Бисквитки за проследяване и за производителност","pc_trck_text_2":"Тези бисквитки се използват за събиране на информация за анализ на трафика към нашия уебсайт и как посетителите използват нашия уебсайт.","pc_trck_text_3":"Например, тези бисквитки могат да проследяват неща като колко време прекарвате на уебсайта или на посещаваните от вас страници, което ни помага да разберем как можем да подобрим нашия сайт за вас.","pc_trck_text_4":"Информацията, събрана чрез тези бисквитки за проследяване и производителност, не идентифицира всеки отделен посетител.","pc_trgt_text_1":"Насочване и рекламни бисквитки","pc_trgt_text_2":"Тези бисквитки се използват за показване на реклама, която вероятно ще ви заинтересова въз основа на навиците ви за сърфиране.","pc_trgt_text_3":"Тези бисквитки, обслужвани от нашите доставчици на съдържание и / или реклама, могат да комбинират информацията, която са събрали от нашия уебсайт, с друга информация, която са събрали независимо, свързана с дейностите на вашия уеб браузър в тяхната мрежа от уебсайтове.","pc_trgt_text_4":"Ако решите да премахнете или деактивирате тези бисквитки за определени потребителски групи или реклама, пак ще видите реклами, но те може да не са от подходящи за вас.","pc_yprivacy_text_1":"Вашата поверителност е важна за нас","pc_yprivacy_text_2":"Бисквитките са много малки текстови файлове, които се съхраняват на вашия компютър, когато посетите уебсайт. Ние използваме бисквитки за множество от цели и да подобрим сърфирането ви из нашия сайт (например: за да запомним детайлите на вашия акаунт за влизане).","pc_yprivacy_text_3":"Можете да промените предпочитанията си и да откажете определени видове бисквитки, които да се съхраняват на вашия компютър, докато сърфирате в нашия уебсайт. Можете също да премахнете някои бисквитки, които вече са запазени на вашия компютър, но имайте предвид, че изтриването на бисквитки може да ви попречи да използвате части от нашия уебсайт.","pc_yprivacy_title":"Вашата поверителност","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Страница за поверителност</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Ενεργό","always_active":"Πάντα ενεργό","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Ανενεργό","nb_agree":"Συμφωνώ","nb_changep":"Αλλαγή των προτιμήσεών μου","nb_ok":"OK","nb_reject":"Αρνούμαι","nb_text":"Χρησιμοποιούμε cookies και άλλες τεχνολογίες εντοπισμού για την βελτίωση της εμπειρίας περιήγησης στην ιστοσελίδα μας, για την εξατομίκευση περιεχομένου και διαφημίσεων, την παροχή λειτουργιών κοινωνικών μέσων και την ανάλυση της επισκεψιμότητάς μας.","nb_title":"Αυτή η ιστοσελίδα χρησιμοποιεί cookies","pc_fnct_text_1":"Cookies Λειτουργικότητας","pc_fnct_text_2":"Αυτά τα cookies χρησιμοποιούνται για να σας παρέχουν μία πιο προσωποποιημένη εμπειρία στην ιστοσελίδα μας και για να θυμούνται επιλογές που κάνετε όταν χρησιμοποιείτε την ιστοσελίδα μας.","pc_fnct_text_3":"Για παράδειγμα, μπορεί να χρησιμοποιήσουμε cookies λειτουργικότητας για να θυμόμαστε την επιλογή γλώσσας ή τα στοιχεία εισόδου σας.","pc_minfo_text_1":"Περισσότερες πληροφορίες","pc_minfo_text_2":"Για οποιαδήποτε απορία σε σχέση με την πολιτική μας σχετικά με τα cookies και τις επιλογές σας, παρακαλούμε να έρθετε σε επαφή μαζί μας.","pc_minfo_text_3":"Για να μάθετε περισσότερα, παρακαλούμε επισκεφθείτε την σελίδα περί <a href=\'%s\' target=\'_blank\'>Πολιτική απορρήτου</a>.","pc_save":"Αποθήκευση των προτιμήσεών μου","pc_sncssr_text_1":"Άκρως απαραίτητα cookies","pc_sncssr_text_2":"Τα απαραίτητα cookies βοηθούν στο να γίνει χρηστική μία ιστοσελίδα, επιτρέποντας βασικές λειτουργίες όπως την πλοήγηση και την πρόσβαση σε ασφαλείς περιοχές της ιστοσελίδας.","pc_sncssr_text_3":"Η ιστοσελίδα δεν μπορεί να λειτουργήσει σωστά χωρίς αυτά τα cookies.","pc_title":"Κέντρο Προτιμήσεων Cookies","pc_trck_text_1":"Cookies εντοπισμού και αποδοτικότητας","pc_trck_text_2":"Αυτά τα cookies χρησιμοποιούνται για να συλλέγουν πληροφορίες σχετικές με την ανάλυση της επισκεψιμότητας της ιστοσελίδας μας και με το πώς οι χρήστες την χρησιμοποιούν.","pc_trck_text_3":"Για παράδειγμα, αυτά τα cookies μπορεί να εντοπίσουν πόσο χρόνο αφιερώνετε στην ιστοσελίδα μας ή ποιες σελίδες της επισκέπτεστε, πράγμα που μας βοηθάει να καταλάβουμε πώς να βελτιώσουμε την ιστοσελίδα μας.","pc_trck_text_4":"Οι πληροφορίες που συλλέγονται μέσω αυτών των cookies δεν αναγνωρίζουν μεμονωμένους χρήστες.","pc_trgt_text_1":"Cookies εξατομικευμένου περιεχομένου και διαφημίσεων","pc_trgt_text_2":"Αυτά τα cookies χρησιμοποιούνται για να δείχνουν διαφημίσεις που μπορεί να σας ενδιαφέρουν με βάση τις συνήθειες περιήγησής σας στο Διαδίκτυο.","pc_trgt_text_3":"Αυτά τα cookies, παρέχονται από τους παρόχους περιεχομένου ή/και διαφημίσεων, μπορεί να συνδυάζουν πληροφορίες που συλλέγουν από την ιστοσελίδα μας με άλλες που έχουν ανεξάρτητα συλλέξει από άλλα δίκτυα ή ιστοσελίδες σχετικά με τις δραστηριότητές σας στον φυλλομετρητή σας.","pc_trgt_text_4":"Εάν επιλέξετε να αφαιρέσετε ή να απενεργοποιήσετε αυτά τα cookies, θα συνεχίσετε να βλέπετε διαφημίσεις, αλλά αυτές μπορεί να μην είναι πλέον σχετικές με τα ενδιαφέροντά σας.","pc_yprivacy_text_1":"Η ιδιωτικότητά σας είναι σημαντική για εμάς","pc_yprivacy_text_2":"Τα cookies είναι πολύ μικρά αρχεία κειμένου που αποθηκεύονται στον υπολογιστή σας όταν επισκέπτεστε μια ιστοσελίδα. Χρησιμοποιούμε cookies για διάφορους λόγους και για να βελτιώσουμε την διαδικτυακή σας εμπειρία στην ιστοσελίδα μας (π.χ., για υπενθύμιση των στοιχείων πρόσβασής σας στην ιστοσελίδα).","pc_yprivacy_text_3":"Μπορείτε να αλλάξετε τις προτιμήσεις σας και να μην επιτρέψετε σε κάποιους τύπους cookies να αποθηκευτούν στον υπολογιστή σας όσο περιηγείστε στην ιστοσελίδα μας. Μπορείτε επίσης να διαγράψετε οποιαδήποτε cookies είναι ήδη αποθηκευμένα στον υπολογιστή σας, αλλά να έχετε υπόψιν ότι διαγράφοντας cookies μπορεί να σας αποτρέψει από το να χρησιμοποιήσετε μέρη της ιστοσελίδας μας.","pc_yprivacy_title":"Η ιδιωτικότητά σας","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Πολιτική απορρήτου</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"פעיל","always_active":"תמיד פעיל","impressum":"<a href=\'%s\' target=\'_blank\'>רושם</a>","inactive":"לא פעיל","nb_agree":"אני מסכים/ה","nb_changep":"שנה את ההגדרות שלי","nb_ok":"אוקיי","nb_reject":"אני מסרב/ת","nb_text":"אנו משתמשים בעוגיות ובטכנולוגיות מעקב אחרות כדי לשפר את חווית הגלישה שלך באתר האינטרנט שלנו, כדי להציג לך תוכן מותאם אישית ומודעות ממוקדות, לנתח את התנועה באתר שלנו ולהבין מהיכן מגיעים המבקרים שלנו.","nb_title":"אנו משתמשים בעוגיות","pc_fnct_text_1":"עוגיות פונקציונליות","pc_fnct_text_2":"עוגיות אלה משמשות כדי לספק לך חוויה מותאמת אישית יותר באתר האינטרנט שלנו וכדי לזכור בחירות שאתה עושה כשאתה משתמש באתר שלנו.","pc_fnct_text_3":"לדוגמה, אנו עשויים להשתמש בעוגיות פונקציונליות כדי לזכור את העדפות השפה שלך או לזכור את פרטי ההתחברות שלך.","pc_minfo_text_1":"מידע נוסף","pc_minfo_text_2":"לכל שאלה בנוגע למדיניות שלנו בנושא קובצי עוגיות והבחירות שלך, אנא צור איתנו קשר.","pc_minfo_text_3":"למידע נוסף, בקר ב<a href=\'%s\' target=\'_blank\'>מדיניות הפרטיות</a> שלנו.","pc_save":"שמור את ההעדפות שלי","pc_sncssr_text_1":"עוגיות נחוצות בלבד","pc_sncssr_text_2":"עוגיות אלו חיוניות כדי לספק לך שירותים הזמינים דרך האתר שלנו וכדי לאפשר לך להשתמש בתכונות מסוימות של האתר שלנו.","pc_sncssr_text_3":"ללא עוגיות אלה, איננו יכולים לספק לך שירותים מסוימים באתר שלנו.","pc_title":"מרכז העדפות עוגיות","pc_trck_text_1":"עוגיות מעקב","pc_trck_text_2":"עוגיות אלו משמשות לאיסוף מידע כדי לנתח את התנועה לאתר שלנו וכיצד המבקרים משתמשים באתר שלנו.","pc_trck_text_3":"לדוגמה, קובצי עוגיות אלה עשויים לעקוב אחר דברים כגון משך הזמן שאתה מבלה באתר או הדפים שבהם אתה מבקר, מה שעוזר לנו להבין כיצד אנו יכולים לשפר עבורך את אתר האינטרנט שלנו.","pc_trck_text_4":"המידע שנאסף באמצעות עוגיות מעקב וביצועים אלה אינו מזהה אף מבקר בודד.","pc_trgt_text_1":"עוגיות מיקוד ופרסום","pc_trgt_text_2":"עוגיות אלו משמשות להצגת פרסומות שסביר להניח שיעניינו אותך בהתבסס על הרגלי הגלישה שלך.","pc_trgt_text_3":"קובצי עוגיות אלה, כפי שמוצגים על ידי ספקי התוכן ו/או הפרסום שלנו, עשויים לשלב מידע שהם אספו מהאתר שלנו עם מידע אחר שהם אספו באופן עצמאי הקשור לפעילויות של דפדפן האינטרנט שלך ברחבי רשת האתרים שלהם.","pc_trgt_text_4":"אם תבחר להסיר או להשבית את קובצי המיקוד או קובצי הפרסום הללו, עדיין תראה פרסומות אך ייתכן שהן לא יהיו רלוונטיות עבורך.","pc_yprivacy_text_1":"הפרטיות שלך חשובה לנו","pc_yprivacy_text_2":"קובצי עוגיות הם קבצי טקסט קטנים מאוד המאוחסנים במחשב שלך כאשר אתה מבקר באתר. אנו משתמשים בקובצי עוגיות למגוון מטרות וכדי לשפר את החוויה המקוונת שלך באתר האינטרנט שלנו (לדוגמה, כדי לזכור את פרטי הכניסה לחשבון שלך).","pc_yprivacy_text_3":"אתה יכול לשנות את ההעדפות שלך ולדחות סוגים מסוימים של עוגיות שישמרו במחשב שלך בזמן הגלישה באתר שלנו. אתה יכול גם להסיר קובצי עוגיות שכבר מאוחסנים במחשב שלך, אך זכור שמחיקת קובצי עוגיות עלולה למנוע ממך להשתמש בחלקים מהאתר שלנו.","pc_yprivacy_title":"הפרטיות שלך","privacy_policy":"<a href=\'%s\' target=\'_blank\'>מדיניות פרטיות</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Активно","always_active":"Секогаш активно","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Неактивно","nb_agree":"Се согласувам","nb_changep":"Промени ги моите преференции","nb_ok":"Се согласувам","nb_reject":"Одбивам","nb_text":"Ние користиме колачиња и други технологии за следење за да го подобриме вашето искуство со прелистувањето на нашата веб страна, за да ви прикажеме персонализирана содржина и таргетирани реклами, да го анализираме сообраќајот на нашата веб страна и да разбереме од каде доаѓаат нашите посетители.","nb_title":"Ние користиме колачиња","pc_fnct_text_1":"Колачиња за функционалност","pc_fnct_text_2":"Овие колачиња се користат за да ви овозможат поперсонализирано искуство на нашата веб страна и да ги запомнат изборите што ги правите кога ја користите нашата веб страна.","pc_fnct_text_3":"На пример, може да користиме функционални колачиња за да ги запомниме вашите јазични преференции или да ги запомниме вашите детали за најавување.","pc_minfo_text_1":"Повеќе информации","pc_minfo_text_2":"За било какви прашања во врска со нашата политика за колачиња и вашиот избор, ве молиме контактирајте не.","pc_minfo_text_3":"За да дознаете повеќе, ве молиме посетете ја нашата <a href=\'%s\' target=\'_blank\'>Политика за Приватност</a>.","pc_save":"Зачувај ги моите преференции","pc_sncssr_text_1":"Строго неопходни колачиња","pc_sncssr_text_2":"Овие колачиња се од суштинско значење за да ви овозможат услуги достапни преку нашата веб страна, и да ви овозможат да користите одредени функции на нашата веб страна.","pc_sncssr_text_3":"Без овие колачиња, ние не можеме да ви обезбедиме одредени услуги на нашата веб страна.","pc_title":"Центар за преференци за колачиња","pc_trck_text_1":"Колачиња за следење","pc_trck_text_2":"Овие колачиња се користат за собирање информации за анализа на сообраќајот кон нашата веб страна, и за тоа како посетителите ја користат нашата веб страна.","pc_trck_text_3":"Овие колачиња може да следат работи како на пример, колку време поминувате на веб страната, или страниците што ги посетувате што ни помага да разбереме како можеме да ја подобриме нашата веб страна за вас.","pc_trck_text_4":"Информациите собрани преку овие колачиња за следење и перформанси не идентификуваат поединечни посетители.","pc_trgt_text_1":"Колачиња за таргетирање и рекламирање","pc_trgt_text_2":"Овие колачиња се користат за прикажување реклами што најверојатно ќе ве интересираат врз основа на вашите навики на прелистување.","pc_trgt_text_3":"Овие колачиња, сервирани од нашата содржина и/или провајдери за рекламирање, може да ги комбинираат информациите што ги собрале од нашата веб страна со други информации што независно ги собрале во врска со активностите на вашиот веб-прелистувач низ нивната мрежа на веб страни.","pc_trgt_text_4":"Ако изберете да ги отстраните или оневозможите овие колачиња за таргетирање или рекламирање, сè уште ќе гледате реклами, но тие можеби нема да бидат релевантни за вас.","pc_yprivacy_text_1":"Вашата приватност е важна за нас","pc_yprivacy_text_2":"Колачињата се многу мали текстуални датотеки што се складираат на вашиот компјутер кога посетувате веб страна. Ние користиме колачиња за различни цели и за да го подобриме вашето онлајн искуство на нашата веб страна (на пример, за да ги запомниме деталите за најавување на вашата сметка).","pc_yprivacy_text_3":"Можете да ги промените вашите параметри и да одбиете одредени видови колачиња да се складираат на вашиот компјутер додека ја прелистувате нашата веб страна. Можете исто така да ги отстраните сите колачиња што се веќе зачувани на вашиот компјутер, но имајте во предвид дека бришењето колачиња може да ве спречи да користите делови од нашата веб страна.","pc_yprivacy_title":"Вашата приватност","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Политика за Приватност</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Gweithredol","always_active":"Yn weithredol bob tro","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Anweithredol","nb_agree":"Rwy\'n cytuno","nb_changep":"Newid fy newisiadau","nb_ok":"Iawn","nb_reject":"Rwy\'n gwrthod","nb_text":"Rydym yn defnyddio cwcis a thechnolegau tracio eraill i wella eich profiad o bori ar ein gwefan, i ddangos cynnwys wedi ei bersonoli a hysbysebion wedi\'u targedu, i ddadansoddi traffig ar ein gwefan ac i ddeall o ble daw ein hymwelwyr.","nb_title":"Rydym yn defnyddio cwcis","pc_fnct_text_1":"Cwcis swyddogaeth","pc_fnct_text_2":"Mae\'r cwcis yma yn cael eu defnyddio i ddarparu profiad mwy personol ichi ar ein gwefan, ac i gofio dewisiadau a wnewch wrth ddefnyddio ein gwefan.","pc_fnct_text_3":"Er enghraifft, gallem ddefnyddio cwcis swyddogaeth i gofio\'ch dewis iaith neu gofio\'ch manylion mewngofnodi.","pc_minfo_text_1":"Rhagor o wybodaeth","pc_minfo_text_2":"Os oes gennych chi unrhyw ymholiadau yn ymwneud â\'n polisi cwcis a\'ch dewisiadau, a wnewch chi gysylltu â ni.","pc_minfo_text_3":"I ganfod mwy, ewch at ein <a href=\'%s\' target=\'_blank\'>Polasaí Príobháideachta</a>.","pc_save":"Cadw fy newisiadau","pc_sncssr_text_1":"Cwcis hollol hanfodol","pc_sncssr_text_2":"Mae\'r cwcis yma yn hanfodol er mwyn ichi dderbyn gwasanaethau drwy ein gwefan a\'ch galluogi i ddefnyddio nodweddion penodol ar ein gwefan.","pc_sncssr_text_3":"Heb y cwcis yma, ni fedrwn ddarparu rhai gwasanaethau penodol ichi ar ein gwefan.","pc_title":"Canolfan Dewisiadau Cwcis","pc_trck_text_1":"Cwcis tracio a pherfformiad","pc_trck_text_2":"Mae\'r cwcis yma yn cael eu defnyddio i gasglu gwybodaeth a dadansoddi traffig i\'n gwefan a sut mae ymwelwyr yn defnyddio\'n gwefan.","pc_trck_text_3":"Er enghraifft, gall y cwcis yma dracio faint o amser rydych yn ei dreulio ar y wefan neu\'r tudalennau rydych yn ymweld â hwy a\'n cynorthwyo i ddeall sut y gallwn wella ein gwefan ar eich cyfer.","pc_trck_text_4":"Nid yw\'r wybodaeth a gesglir drwy\'r cwcis tracio a pherfformiad yn adnabod unrhyw ymwelydd unigol.","pc_trgt_text_1":"Cwcis targedu a hysbysebu","pc_trgt_text_2":"Mae\'r cwcis yma yn cael eu defnyddio i ddangos hysbysebion sydd yn debygol o fod o ddiddordeb i chi yn seiliedig ar eich arferion pori.","pc_trgt_text_3":"Gall y cwcis yma, fel y\'u gweinyddir gan ein darparwyr cynnwys a/neu hysbysebion, gyfuno gwybodaeth a gasglwyd ganddynt o\'n gwefan gyda gwybodaeth arall maent wedi ei chasglu\'n annibynnol yn seiliedig ar eich gweithgareddau pori ar y rhyngrwyd ar draws eu rhwydweithiau o wefannau.","pc_trgt_text_4":"Os byddwch yn dewis tynnu neu atal y cwcis targedu neu hysbysebu yma, byddwch yn parhau i weld hysbysebion ond mae\'n bosib na fyddant yn berthnasol i chi.","pc_yprivacy_text_1":"Mae eich preifatrwydd yn bwysig i ni","pc_yprivacy_text_2":"Ffeiliau testun bach eu maint yw cwcis sydd yn cael eu storio ar eich cyfrifiadur wrth ichi ymweld â gwefan. Rydym yn defnyddio cwcis i sawl diben ac i wella eich profiad ar-lein ar ein gwefan (er enghraifft, cofio eich manylion mewngofnodi i\'ch cyfrif).","pc_yprivacy_text_3":"Gallwch newid eich dewisiadau ac atal rhai mathau o gwcis rhag cael eu storio ar eich cyfrifiadur. Gallwch hefyd dynnu unrhyw gwcis sydd eisoes wedi eu storio ar eich cyfrifiadur, ond cofiwch y gall.","pc_yprivacy_title":"Eich preifatrwydd","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Polasaí Príobháideachta</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"アクティブ","always_active":"常にアクティブ","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"停止中","nb_agree":"同意","nb_changep":"設定変更","nb_ok":"承諾","nb_reject":"拒否","nb_text":"訪問者の当ウェブサイトの閲覧体験を向上させるため、パーソナライズされたコンテンツやターゲット広告を表示するため、当ウェブサイトのトラフィックを分析するため、および当ウェブサイトへの訪問者がどこから来ているかを理解するために、Cookieおよびその他の追跡技術を使用しています。","nb_title":"クッキーの使用","pc_fnct_text_1":"機能性クッキー","pc_fnct_text_2":"これらのクッキーは、当ウェブサイトでよりカスタマイズされた体験を提供するため、および当ウェブサイトを利用する際に行った選択を記憶するために使用されます。","pc_fnct_text_3":"例えば、訪問者の言語設定を記憶したり、ログイン情報を記憶するために、機能性クッキーを使用することがあります。","pc_minfo_text_1":"詳細情報","pc_minfo_text_2":"クッキーに関する方針や訪問者の選択に関連したご質問については、当方までお問い合わせください。","pc_minfo_text_3":"詳しくは、<a href=\'%s\' target=\'_blank\'>プライバシーポリシー</a> をご覧ください。","pc_save":"設定を保存","pc_sncssr_text_1":"ウェブサイトの動作に必要不可欠なクッキー","pc_sncssr_text_2":"これらのクッキーは、訪問者が当ウェブサイトを通じて利用可能なサービスを提供したり、当ウェブサイトの特定の機能を利用したりするために不可欠なものです。","pc_sncssr_text_3":"これらのクッキーをブロックした場合、当ウェブサイトでの特定のサービスを提供できません。","pc_title":"クッキー設定センター","pc_trck_text_1":"トラッキングクッキー","pc_trck_text_2":"これらのクッキーは、当ウェブサイトへのトラフィックや訪問者がどのように当ウェブサイトを利用しているかを分析するための情報を収集するために使用されます。","pc_trck_text_3":"例えば、これらのクッキーは、訪問者が当ウェブサイトに滞在した時間や訪問したページなどを追跡することがあり、これは、訪問者のために当ウェブサイトの利便性向上に役立てます。","pc_trck_text_4":"これらのトラッキングおよびパフォーマンスクッキーによって収集された情報は、特定の個人を特定することはありません。","pc_trgt_text_1":"ターゲティングおよび広告用クッキー","pc_trgt_text_2":"これらのクッキーは、訪問者の閲覧習慣に基づいて、訪問者が興味を持ちそうな広告を表示するために使用されます。","pc_trgt_text_3":"これらのクッキーは、コンテンツプロバイダーおよび/または広告プロバイダーによって提供され、当ウェブサイトから収集した情報と、そのネットワーク上での訪問者のウェブブラウザの活動に関連して独自に収集した他の情報とを組み合わせることがあります。","pc_trgt_text_4":"訪問者がこれらのターゲティングクッキーや広告用クッキーを削除または無効を選択した場合でも、広告は表示されますが、訪問者に関連したものではない可能性があります。","pc_yprivacy_text_1":"お客様のプライバシーを尊重します","pc_yprivacy_text_2":"クッキーとは、訪問者がウェブサイトにアクセスした際に訪問者のコンピュータに保存される非常に小さなテキストファイルです。当ウェブサイトは、さまざまな目的でクッキーを使用し、当ウェブサイトでの訪問者のオンライン利便性を向上させています。（例えば、訪問者のアカウントのログイン情報を記憶するためなど。）","pc_yprivacy_text_3":"訪問者は、設定を変更して、当ウェブサイトを閲覧中のコンピュータに保存される特定の種類のクッキーを拒否することができます。また、すでに訪問者のコンピュータに保存されているクッキーを削除することもできますが、クッキーを削除すると、当ウェブサイト機能の一部が利用できなくなる可能性がありますので、ご注意ください。","pc_yprivacy_title":"プライバシー","privacy_policy":"<a href=\'%s\' target=\'_blank\'>プライバシーポリシー</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"تغيير تفضيلاتي","always_active":"مفعل دائمًا","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"غير مفعل","nb_agree":"موافق","nb_changep":"تغيير تفضيلاتي","nb_ok":"فهمت","nb_reject":"أرفض","nb_text":"نحن نستخدم ملفات تعريف الارتباط وتقنيات التتبع الأخرى لتحسين تجربة التصفح الخاصة بك على موقعنا الإلكتروني ، ولإظهار المحتوى المخصص والإعلانات المستهدفة لك ، وتحليل حركة المرور على موقعنا ، وفهم من أين يأتي زوارنا.","nb_title":"نحنُ نستخدم ملفات تعريف الارتباط","pc_fnct_text_1":"ملفات تعريف الارتباط الوظيفية","pc_fnct_text_2":"تُستخدم ملفات تعريف الارتباط هذه لتزويدك بتجربة أكثر تخصيصًا على موقعنا الإلكتروني ولتذكر الخيارات التي تتخذها عند استخدامك لموقعنا.","pc_fnct_text_3":"على سبيل المثال ، قد نستخدم ملفات تعريف الارتباط الوظيفية لتذكر تفضيلات اللغة الخاصة بك أو تذكر تفاصيل تسجيل الدخول الخاصة بك.","pc_minfo_text_1":"معلومات أكثر.","pc_minfo_text_2":"لأي استفسارات تتعلق بسياستنا الخاصة بملفات تعريف الارتباط ، وخياراتك،  يرجى التواصل معنا.","pc_minfo_text_3":"<a href=\'%s\' target=\'_blank\'>\\nالخاصة بنا لمعرفة المزيد ، يرجى زيارةسياسة الخصوصية .\\n</a>","pc_save":"حفظ تفضيلاتي","pc_sncssr_text_1":"ملفات تعريف الارتباط الضرورية للغاية","pc_sncssr_text_2":"تعد ملفات تعريف الارتباط هذه ضرورية لتزويدك بالخدمات المتاحة عبر موقعنا على الويب ولتمكينك من استخدام ميزات معينة في موقعنا .","pc_sncssr_text_3":"بدون ملفات تعريف الارتباط هذه ، لا يمكننا تقديم خدمات معينة لك على موقعنا.","pc_title":"مركز تفضيلات ملفات تعريف الارتباط","pc_trck_text_1":"ملفات تعريف الارتباط للتتبع والأداء","pc_trck_text_2":"\\nتُستخدم ملفات تعريف الارتباط هذه لجمع المعلومات لتحليل حركة المرور إلى موقعنا الإلكتروني وكيفية استخدام الزوار لموقعنا.","pc_trck_text_3":"\\nعلى سبيل المثال ، قد تتعقب ملفات تعريف الارتباط هذه أشياء مثل المدة التي تقضيها على موقع الويب أو الصفحات التي تزورها مما يساعدنا على فهم كيف يمكننا تحسين موقعنا على الويب من أجلك.","pc_trck_text_4":"\\nالمعلومات التي يتم جمعها من خلال ملفات تعريف الارتباط الخاصة بالتتبع والأداء هذه لا تحدد أي زائر فردي.\\n","pc_trgt_text_1":"ملفات تعريف الارتباط الخاصة بالاستهداف والإعلان","pc_trgt_text_2":"تُستخدم ملفات تعريف الارتباط هذه لإظهار الإعلانات التي من المحتمل أن تهمك بناءً على عاداتك في التصفح.","pc_trgt_text_3":"\\nقد تدمج ملفات تعريف الارتباط هذه ، كما يقدمها المحتوى و / أو موفرو الإعلانات لدينا ، المعلومات التي جمعوها من موقعنا الإلكتروني مع المعلومات الأخرى التي جمعوها بشكل مستقل فيما يتعلق بأنشطة متصفح الويب الخاص بك عبر شبكة مواقعهم الإلكترونية.\\n","pc_trgt_text_4":"إذا اخترت إزالة أو تعطيل ملفات تعريف الارتباط الخاصة بالاستهداف أو الإعلانات ، فستظل تشاهد إعلانات ولكنها قد لا تكون ذات صلة بك.","pc_yprivacy_text_1":"خصوصيتك مهمة بالنسبة لنا","pc_yprivacy_text_2":"من الأغراض ولتعزيز تجربتك عبر الإنترنت على موقعنا (على سبيل المثال ، لتذكر تفاصيل تسجيل الدخول إلى حسابك).","pc_yprivacy_text_3":"يمكنك تغيير تفضيلاتك ورفض أنواع معينة من ملفات تعريف الارتباط ليتم تخزينها على جهاز الكمبيوتر الخاص بك أثناء تصفح موقعنا على الويب.  يمكنك أيضًا إزالة أي ملفات تعريف ارتباط مخزنة بالفعل على جهاز الكمبيوتر الخاص بك ، ولكن ضع في اعتبارك أن حذف ملفات تعريف الارتباط قد يمنعك من استخدام أجزاء من موقعنا.","pc_yprivacy_title":"خصوصيتك","privacy_policy":"<a href=\'%s\' target=\'_blank\'>\\nةسياسة الخصوصية\\n</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"Etkin","always_active":"Her zaman etkin","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"Etkin değil","nb_agree":"Kabul et","nb_changep":"Tercihleri değiştir","nb_ok":"Tamam","nb_reject":"Reddet","nb_text":"Web sitemizde gezinme deneyiminizi geliştirmek, size kişiselleştirilmiş içerik ve hedefli reklamlar göstermek, web sitesi trafiğimizi analiz etmek ve ziyaretçilerimizin nereden geldiğini anlamak için çerezleri ve diğer izleme teknolojilerini kullanıyoruz.","nb_title":"Çerezleri kullanıyoruz","pc_fnct_text_1":"İşlevsellik çerezleri","pc_fnct_text_2":"Bu çerezler, web sitemizde size daha kişiselleştirilmiş bir deneyim sağlamak ve web sitemizi kullanırken yaptığınız seçimleri hatırlamak için kullanılır.","pc_fnct_text_3":"Örneğin, dil tercihlerinizi veya oturum açma bilgilerinizi hatırlamak için işlevsellik tanımlama bilgilerini kullanabiliriz.","pc_minfo_text_1":"Daha fazla bilgi","pc_minfo_text_2":"Çerezlere ilişkin politikamız ve seçimlerinizle ilgili herhangi bir sorunuz için lütfen bizimle iletişime geçin","pc_minfo_text_3":"Daha fazlasını öğrenmek için lütfen <a href=\'%s\' target=\'_blank\'>Gizlilik Politikası</a> ziyaret edin.","pc_save":"Tercihleri Kaydet","pc_sncssr_text_1":"Kesinlikle gerekli çerezler","pc_sncssr_text_2":"Bu çerezler, size web sitemiz aracılığıyla sunulan hizmetleri sağlamak ve web sitemizin belirli özelliklerini kullanmanızı sağlamak için gereklidir.","pc_sncssr_text_3":"Bu çerezler olmadan, web sitemizde size belirli hizmetleri sağlayamayız.","pc_title":"Çerez Tercihleri Merkezi","pc_trck_text_1":"İzleme ve performans çerezleri","pc_trck_text_2":"Bu çerezler, web sitemize gelen trafiği ve ziyaretçilerin web sitemizi nasıl kullandığını analiz etmek için bilgi toplamak amacıyla kullanılır.","pc_trck_text_3":"Örneğin, çerezler, web sitesinde ne kadar zaman geçirdiğiniz veya ziyaret ettiğiniz sayfalar gibi şeyleri izleyebilir ve bu da web sitemizi sizin için nasıl iyileştirebileceğimizi anlamamıza yardımcı olur.","pc_trck_text_4":"Bu izleme ve performans çerezleri aracılığıyla toplanan bilgiler anonim olup herhangi bir bireysel ziyaretçiyi tanımlamaz.","pc_trgt_text_1":"Hedefleme ve reklam çerezleri","pc_trgt_text_2":"Bu çerezler, arama/gezinme alışkanlıklarınıza göre ilginizi çekebilecek reklamları göstermek için kullanılır.","pc_trgt_text_3":"Bu çerezler, içerik ve/veya reklam sağlayıcılarımız tarafından, web sitemizden topladıkları bilgileri, web tarayıcınızın kendi web siteleri ağlarındaki faaliyetleriyle ilgili olarak bağımsız olarak topladıkları diğer bilgilerle birleştirilebilir.","pc_trgt_text_4":"Bu hedefleme veya reklam çerezlerini kaldırmayı veya devre dışı bırakmayı seçerseniz, reklamları görmeye devam edersiniz, ancak bunlar sizinle alakalı olmayabilir.","pc_yprivacy_text_1":"Gizliliğiniz bizim için önemlidir","pc_yprivacy_text_2":"Çerezler, bir web sitesini ziyaret ettiğinizde bilgisayarınızda depolanan çok küçük metin dosyalarıdır. Çerezleri çeşitli amaçlarla ve web sitemizdeki çevrimiçi deneyiminizi geliştirmek için (örneğin, hesap giriş bilgilerinizi hatırlamak için) kullanıyoruz.","pc_yprivacy_text_3":"Web sitemizde gezinirken tercihlerinizi değiştirebilir ve bilgisayarınızda saklanacak belirli çerez türlerini reddedebilirsiniz. Ayrıca, bilgisayarınızda depolanmış olan çerezleri de kaldırabilirsiniz, ancak çerezleri silmenin web sitemizin bölümlerini kullanmanızı engelleyebileceğini unutmayın.","pc_yprivacy_title":"Gizliliğiniz","privacy_policy":"<a href=\'%s\' target=\'_blank\'>Gizlilik Politikası</a>"}}')},function(e){e.exports=JSON.parse('{"i18n":{"active":"啟用","always_active":"永遠啟用","impressum":"<a href=\'%s\' target=\'_blank\'>Impressum</a>","inactive":"停用","nb_agree":"我同意","nb_changep":"更改我的偏好","nb_ok":"確定","nb_reject":"我拒絕","nb_text":"我們使用cookies和其他追蹤技術來改善您在我們網站上的瀏覽體驗，對您顯示個性化的內容和有針對性的廣告，分析我們的網站流量，並了解我們的訪客來自哪裡。","nb_title":"我們使用cookies","pc_fnct_text_1":"功能性cookies","pc_fnct_text_2":"這些cookies用於在我們的網站上為您提供更加個人化的體驗，並記住您在使用我們網站時做出的選擇。","pc_fnct_text_3":"例如，我們可能使用功能性cookies來記住您的語言偏好或記住您的登入資訊。","pc_minfo_text_1":"更多資訊","pc_minfo_text_2":"如果對我們的cookies政策或您的選擇有任何疑問，請聯繫我們。","pc_minfo_text_3":"想了解更多資訊，請前往我們的<a href=\'%s\' target=\'_blank\'>隱私權政策</a>.","pc_save":"儲存我的偏好","pc_sncssr_text_1":"必要的cookies","pc_sncssr_text_2":"這些cookies對於向您提供透過我們網站的服務以及使您能夠使用我們網站的某些功能是不可或缺的。","pc_sncssr_text_3":"沒有這些cookies，我們就不能在我們的網站上為您提供某些服務。","pc_title":"Cookies偏好中心","pc_trck_text_1":"追蹤cookies","pc_trck_text_2":"這些cookies用於收集資訊，以分析我們網站的流量以及訪客如何使用我們的網站。","pc_trck_text_3":"例如，這些cookies可能會跟追蹤如您在網站上花費的時間或您造訪的頁面，這有助於我們了解如何為您改進我們的網站。","pc_trck_text_4":"透過這些追蹤和性能cookies收集的資訊不會識別任何個人訪客。","pc_trgt_text_1":"定位和廣告cookies","pc_trgt_text_2":"這些cookies被用來根據您的瀏覽習慣顯示您可能感興趣的廣告。","pc_trgt_text_3":"由我們的內容或廣告供應商提供的這些cookies，可能會將他們從我們的網站上收集的資訊和他們獨立收集的與您的瀏覽器在其網站中的活動有關的其他資訊結合起來。","pc_trgt_text_4":"如果您選擇刪除或禁用這些定位或廣告cookies，您仍然會看到廣告，但它們可能與您無關。","pc_yprivacy_text_1":"您的隱私對我們很重要","pc_yprivacy_text_2":"Cookies是非常小的文本文件，當您造訪網站時存儲在您的裝置上。我們將cookies用於各種目的，並提高您在我們網站的使用體驗（例如，記住您帳號的登入資訊）。","pc_yprivacy_text_3":"在瀏覽我們的網站時，您可以改變您的偏好，拒絕某些類型的cookies儲存在您的裝置上。您也可以刪除已經儲存在您裝置上的任何cookies，但請記住，刪除cookies可能會導致您無法使用我們網站的部分內容。","pc_yprivacy_title":"您的隱私","privacy_policy":"<a 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de temps passatz sus un site web o las paginas que consultatz, çò que nos permet de comprendre coma podèm melhorar nòstre site web per vos.","pc_trck_text_4":"Las informacions collectadas via aqueles cookies de seguiment e de performància identifican pas individualament cap de visitaire.","pc_trgt_text_1":"Cookies de ciblatge e publicitat","pc_trgt_text_2":"Aquestes cookies servisson per afichar de publicitats que vos interessaràn probablament basadas sus vòstras costumas de navegacion.","pc_trgt_text_3":"Aquestes cookies, servits per nòstres provesidors de contenguts e/o publicitats, pòdon combinar d’informacions que collèctan de nòstre site web amb d’autras informacions qu’an collectadas independentament en relacion amb las activitats de vòstre navegador a travèrs lor malhum de sites web.","pc_trgt_text_4":"Se causissètz de suprimir o desactivar aquestes cookies  publicitaris o de ciblatge, veiretz totjorn de reclamas mas seràn pas pertinentas per vos.","pc_yprivacy_text_1":"Vòstra vida privada nos impòrta","pc_yprivacy_text_2":"Los cookies son de plan pichons fichièrs tèxt que son gardas dins vòstre ordenador quand visitatz un site. Utilizam los cookies per mantuna tòca e per melhorar vòstra experiéncia en linha sus nòstre site web (per exemple, per memorizar vòstre identificant de connexion).","pc_yprivacy_text_3":"Podètz modificar vòstras preferéncias e regetar certans tipes de cookies de gardar dins vòstre ordenador en navegant sus nòstre site web. 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t=this,i=document.querySelectorAll(e);t.cookieConsent.log("userButton detected:","info"),t.cookieConsent.log(i,"info","table"),i&&i.forEach((function(e){e.addEventListener("click",(function(){document.dispatchEvent(t.cookieConsent.events.cc_noticeBannerChangePreferencesPressed),t.showPreferencesCenter()}))}))},e.prototype.showPreferencesCenter=function(){var e,t=this;null===this.preferencesCenterOverlay&&(this.preferencesCenterOverlay=this.createPreferencesCenterOverlayAndDialog(),a.appendChild("body",this.preferencesCenterOverlay)),this.preferencesCenterOverlay.classList.add("termsfeed-com---is-visible"),t.cookieConsent.log("Preferences Center shown","info"),this.preferencesCenterOverlay.setAttribute("role","dialog"),this.preferencesCenterOverlay.setAttribute("aria-labelledby","cc-pc-head-title-headline"),this.preferencesCenterOverlay.setAttribute("tabindex","-1"),this.preferencesCenterOverlay.focus();var i=document.querySelector("#termsfeed-com---preferences-center"),n=i.querySelectorAll('button, [href], input, select, textarea, [tabindex]:not([tabindex="-1"])')[0],o=i.querySelectorAll('button, [href], input, select, textarea, [tabindex]:not([tabindex="-1"])'),r=o[o.length-1];t.cookieConsent.log("preferencesCenterOverlayModal_firstFocusableElement: "+n,"info"),t.cookieConsent.log("preferencesCenterOverlayModal_focusableContent: "+o,"info"),t.cookieConsent.log("preferencesCenterOverlayModal_lastFocusableElement: "+r,"info"),document.addEventListener("keydown",(function(e){var i,o;("Tab"===e.key||9===e.keyCode)&&(e.shiftKey?document.activeElement===n&&(t.cookieConsent.log("preferencesCenterOverlayModal_lastFocusableElement before focus: "+r,"info"),null===(i=r)||void 0===i||i.focus(),e.preventDefault()):document.activeElement===r&&(t.cookieConsent.log("preferencesCenterOverlayModal_firstFocusableElement before focus: "+n,"info"),null===(o=n)||void 0===o||o.focus(),e.preventDefault()))})),t.cookieConsent.log("preferencesCenterOverlayModal_firstFocusableElement before focus: "+n,"info"),null===(e=n)||void 0===e||e.focus(),this.preferencesCenterOverlay.classList.add("termsfeed-com---lang-"+t.cookieConsent.i18n.userLang)},e.prototype.hidePreferencesCenter=function(){this.preferencesCenterOverlay.classList.remove("termsfeed-com---is-visible"),this.cookieConsent.log("Preferences Center hidden","info")},e.prototype.refreshPreferencesCenter=function(){if(null!==this.preferencesCenterOverlay)return this.preferencesCenterOverlay.parentNode.removeChild(this.preferencesCenterOverlay),this.preferencesCenterOverlay=null,this.showPreferencesCenter()},e.prototype.createPreferencesCenterOverlayAndDialog=function(){var e=this,t=document.createElement("div");t.classList.add("termsfeed-com---pc-overlay"),t.classList.add(e.cookieConsent.colorPalette.getClass()),t.classList.add("termsfeed-com---reset"),t.id="termsfeed-com---preferences-center",t.setAttribute("id","termsfeed-com---preferences-center");var i=document.createElement("div");i.classList.add("termsfeed-com---pc-dialog");var n=document.createElement("div");n.classList.add("cc-pc-container");var o=document.createElement("div");o.classList.add("cc-pc-head");var r=document.createElement("div");if(r.classList.add("cc-pc-head-title"),e.cookieConsent.ownerWebsiteName.length>2){var s=document.createElement("p");s.classList.add("cc-pc-head-title-text"),s.innerText=e.cookieConsent.ownerWebsiteName,a.appendChild(r,s)}var c=document.createElement("p");c.classList.add("cc-pc-head-title-headline"),c.setAttribute("id","cc-pc-head-title-headline"),c.innerHTML=e.cookieConsent.i18n.$t("i18n","pc_title"),a.appendChild(r,c);var l=document.createElement("div");l.classList.add("cc-pc-head-lang");var p=this.obtainLanguageSelector();a.appendChild(l,p);var d=document.createElement("button");d.classList.add("cc-pc-head-close"),d.innerHTML="&#x2715;",d.addEventListener("click",(function(){document.dispatchEvent(e.cookieConsent.events.cc_preferencesCenterClosePressed)})),a.appendChild(o,r),a.appendChild(o,l),!1===e.cookieConsent.ownerPreferencesCenterCloseButtonHide&&a.appendChild(l,d,"afterend");var u=document.createElement("div");u.classList.add("cc-cp-body");var m=this.getMenuContainer(),_=this.getContentContainer();a.appendChild(u,m),a.appendChild(u,_);var k=this.getFooterContainer();return a.appendChild(n,o),a.appendChild(n,u),a.appendChild(n,k),a.appendChild(i,n),a.appendChild(t,i),t},e.prototype.obtainLanguageSelector=function(){var e=this,t=document.createElement("select");return t.classList.add("cc-pc-head-lang-select"),[].forEach.call(e.cookieConsent.i18n.availableLanguages,(function(i){var n=document.createElement("option");n.text=i.title,n.value=i.value,e.cookieConsent.i18n.userLang===n.value&&n.setAttribute("selected","selected"),t.add(n)})),t.addEventListener("change",(function(){e.cookieConsent.i18n.userLang=t.value,e.cookieConsent.cookieLevels.languageChanged(),e.refreshPreferencesCenter(),document.dispatchEvent(e.cookieConsent.events.cc_userLanguageChanged)})),t},e.prototype.getContentContainer=function(){var e=this,t=document.createElement("div");t.classList.add("cc-cp-body-content");var i=0;return e.cookieConsent.cookieLevels.preferenceItems.forEach((function(n){var o=document.createElement("div");if(o.classList.add("cc-cp-body-content-entry"),o.setAttribute("id",n.content_container),o.setAttribute("role","tabpanel"),o.setAttribute("aria-labelledby",n.title_container),o.setAttribute("hidden",""),o.setAttribute("tabindex","0"),o.setAttribute("content_layout",n.content_container),o.setAttribute("active","false"),o.innerHTML=n.content,0===i&&(o.setAttribute("active","true"),o.removeAttribute("hidden")),i++,n.id){var r=e._getLevelCheckbox(n);a.appendChild(o,r)}a.appendChild(t,o)})),t},e.prototype.getMenuContainer=function(){var e=this,t=document.createElement("ul");t.classList.add("cc-cp-body-tabs"),t.setAttribute("role","tablist"),t.setAttribute("aria-label","Menu");var i=0;return e.cookieConsent.cookieLevels.preferenceItems.forEach((function(n){var o=document.createElement("li");o.classList.add("cc-cp-body-tabs-item");var r=document.createElement("button");r.classList.add("cc-cp-body-tabs-item-link"),r.setAttribute("id",n.title_container),r.setAttribute("role","tab"),r.setAttribute("aria-selected","false"),r.setAttribute("aria-controls",n.content_container),r.setAttribute("tabindex","-1"),r.setAttribute("t",n.content_container),r.innerHTML=n.title,0===i&&(o.setAttribute("active","true"),r.setAttribute("aria-selected","true"),r.setAttribute("tabindex","0")),i++,r.addEventListener("click",(function(t){t.preventDefault(),e.cookieConsent.log("Preferences Center tab item clicked: "+n.title,"info");var i=document.querySelectorAll('li[active="true"]');[].forEach.call(i,(function(e){e.setAttribute("active","false"),e.firstElementChild.setAttribute("aria-selected","false"),e.firstElementChild.setAttribute("tabindex","-1")})),o.setAttribute("active","true"),o.firstElementChild.setAttribute("aria-selected","true"),o.firstElementChild.setAttribute("tabindex","0");try{var a=document.querySelectorAll("div[content_layout]");[].forEach.call(a,(function(e){e.setAttribute("active","false"),e.setAttribute("hidden","")}));var r=document.querySelector('div[content_layout="'+n.content_container+'"]');r.setAttribute("active","true"),r.removeAttribute("hidden")}catch(t){}}));var s=0,c=document.getElementsByClassName("cc-cp-body-tabs-item-link");t.addEventListener("keydown",(function(e){"ArrowDown"!==e.key&&"ArrowUp"!==e.key&&"ArrowLeft"!==e.key&&"ArrowRight"!==e.key||(c[s].setAttribute("tabindex","-1"),"ArrowDown"===e.key||"ArrowRight"===e.key?++s>=c.length&&(s=0):"ArrowUp"!==e.key&&"ArrowLeft"!==e.key||--s<0&&(s=c.length-1),c[s].setAttribute("tabindex","0"),c[s].focus())})),a.appendChild(o,r),a.appendChild(t,o)})),t},e.prototype.getFooterContainer=function(){var e=this,t=document.createElement("div");t.classList.add("cc-cp-foot");var i=document.createElement("div");i.classList.add("cc-cp-foot-byline"),i.innerHTML=a.magicTransform("Q29va2llIENvbnNlbnQgYnkgPGEgaHJlZj0iaHR0cHM6Ly93d3cudGVybXNmZWVkLmNvbS9jb29raWUtY29uc2VudC8iIHRhcmdldD0iX2JsYW5rIj5UZXJtc0ZlZWQ8L2E+");var n=document.createElement("div");n.classList.add("cc-cp-foot-button");var o=document.createElement("button");return o.classList.add("cc-cp-foot-save"),o.innerHTML=e.cookieConsent.i18n.$t("i18n","pc_save"),o.addEventListener("click",(function(){document.dispatchEvent(e.cookieConsent.events.cc_preferencesCenterSavePressed)})),a.appendChild(n,o),a.appendChild(t,i),a.appendChild(t,n),t},e.prototype._getLevelCheckbox=function(e){var t=this,i=document.createElement("div");if(i.classList.add("cc-custom-checkbox"),"strictly-necessary"!==e.id){var n=t.cookieConsent.userConsent.acceptedLevels,o=document.createElement("input");o.setAttribute("cookie_consent_toggler","true"),o.setAttribute("type","checkbox"),o.setAttribute("class","cc-custom-checkbox"),o.setAttribute("id",e.id),o.setAttribute("name",e.id),o.setAttribute("aria-labelledby",e.id+"_label"),(r=document.createElement("label")).setAttribute("for",e.id),r.setAttribute("id",e.id+"_label"),n[e.id]?(o.setAttribute("checked","checked"),o.setAttribute("aria-checked","true"),r.setAttribute("class","is-active"),r.innerHTML=t.cookieConsent.i18n.$t("i18n","active")):(o.setAttribute("aria-checked","false"),r.setAttribute("class","is-inactive"),r.innerHTML=t.cookieConsent.i18n.$t("i18n","inactive")),o.addEventListener("change",(function(){var i=o.checked,n=e.id,a=document.querySelector('label[for="'+n+'"]');t.cookieConsent.log("User changed cookie level ["+n+"], new status: 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r,s=document.createElement("input");s.setAttribute("cookie_consent_toggler","true"),s.setAttribute("type","checkbox"),s.setAttribute("checked","checked"),s.setAttribute("aria-checked","true"),s.setAttribute("disabled","disabled"),s.setAttribute("class","cc-custom-checkbox"),s.setAttribute("id",e.id),s.setAttribute("name",e.id),s.setAttribute("aria-labelledby",e.id+"_label"),s.setAttribute("tabindex","0"),(r=document.createElement("label")).setAttribute("for",e.id),r.setAttribute("id",e.id+"_label"),r.innerHTML=t.cookieConsent.i18n.$t("i18n","always_active"),a.appendChild(i,s),a.appendChild(i,r)}return i},e}(),Y=function(){function e(e){this.noticeBanner=null,this.noticeBannerOverlay=null,this.noticeBannerExtraCss=[],this.cookieConsent=e,this.noticeBannerExtraCss.push(e.colorPalette.getClass())}return e.prototype.initNoticeBanner=function(){var e,t;if(null===this.noticeBanner&&(this.noticeBanner=this.createNoticeBanner()),t="afterbegin"===this.cookieConsent.ownerNoticeBannerAppendContentPosition||"beforeend"===this.cookieConsent.ownerNoticeBannerAppendContentPosition?this.cookieConsent.ownerNoticeBannerAppendContentPosition:"afterbegin",a.appendChild("body",this.noticeBanner,t),this.cookieConsent.log("Notice Banner shown "+t,"info"),document.dispatchEvent(this.cookieConsent.events.cc_noticeBannerShown),"interstitial"===this.cookieConsent.ownerNoticeBannerType||"standalone"===this.cookieConsent.ownerNoticeBannerType){var i=document.querySelector("#termsfeed-com---nb"),n=i.querySelectorAll('button, [href], input, select, textarea, [tabindex]:not([tabindex="-1"])')[0],o=i.querySelectorAll('button, [href], input, select, textarea, [tabindex]:not([tabindex="-1"])'),r=o[o.length-1];document.addEventListener("keydown",(function(e){var t,i;("Tab"===e.key||9===e.keyCode)&&(e.shiftKey?document.activeElement===n&&(null===(t=r)||void 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s=document.createElement("span");s.classList.add("cc-nb-text-urls"),s.innerHTML=" ";var c=document.createElement("span");c.classList.add("cc-nb-text-urls-privacy"),c.setAttribute("role","link");var l=document.createElement("span");l.classList.add("cc-nb-text-urls-impressum"),l.setAttribute("role","link");var p=document.createElement("span");p.classList.add("cc-nb-text-urls-separator"),p.innerHTML=" | 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d=document.createElement("div");d.classList.add("cc-nb-buttons-container");var u=document.createElement("button");u.classList.add("cc-nb-okagree"),u.setAttribute("role","button"),"express"==e.cookieConsent.ownerConsentType?u.innerHTML=e.cookieConsent.i18n.$t("i18n","nb_agree"):u.innerHTML=e.cookieConsent.i18n.$t("i18n","nb_ok"),u.addEventListener("click",(function(){document.dispatchEvent(e.cookieConsent.events.cc_noticeBannerOkOrAgreePressed)})),a.appendChild(d,u);var m=document.createElement("button");m.classList.add("cc-nb-reject"),m.setAttribute("role","button"),m.innerHTML=e.cookieConsent.i18n.$t("i18n","nb_reject"),m.addEventListener("click",(function(){document.dispatchEvent(e.cookieConsent.events.cc_noticeBannerRejectPressed)})),"express"==e.cookieConsent.ownerConsentType&&!1===e.cookieConsent.ownerNoticeBannerRejectButtonHide&&a.appendChild(d,m);var _=document.createElement("button");return _.classList.add("cc-nb-changep"),_.setAttribute("role","button"),_.innerHTML=e.cookieConsent.i18n.$t("i18n","nb_changep"),_.addEventListener("click",(function(){document.dispatchEvent(e.cookieConsent.events.cc_noticeBannerChangePreferencesPressed)})),a.appendChild(d,_),a.appendChild(t,i),a.appendChild(t,o),a.appendChild(t,d),t},e}(),Q=function(e){function t(t){var i=e.call(this,t)||this;return i.noticeBannerExtraCss.push("termsfeed-com---nb-simple"),i}return J(t,e),t}(Y),X=function(e){function t(t){var i=e.call(this,t)||this;return i.noticeBannerExtraCss.push("termsfeed-com---nb-headline"),i}return J(t,e),t}(Y),ee=function(e){function t(t){var i=e.call(this,t)||this;return i.noticeBannerExtraCss.push("termsfeed-com---nb-interstitial"),i}return J(t,e),t}(Y),te=function(e){function t(t){var i=e.call(this,t)||this;return i.noticeBannerExtraCss.push("termsfeed-com---nb-standalone"),i}return J(t,e),t}(Y),ie=function(){function e(e){e.log("ConsentType main class initialized","info")}return e.prototype.loadInitialCookiesForNewUser=function(){},e}(),ne=function(e){function t(t){var i=e.call(this,t)||this;return i.cookieConsent=t,i}return J(t,e),t.prototype.loadInitialCookiesForNewUser=function(){this.cookieConsent.log("consentImplied loadInitialCookiesForNewUser triggered","info");var e=!1,t=!1,i=!1;if(null!==this.cookieConsent.ownerPageLoadConsentLevels)for(var n in this.cookieConsent.ownerPageLoadConsentLevels){var o=this.cookieConsent.ownerPageLoadConsentLevels[n];"functionality"==o&&(e=!0),"tracking"==o&&(t=!0),"targeting"==o&&(i=!0)}else 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diff --git a/stable/site_libs/quarto-html/anchor.min.js b/stable/site_libs/quarto-html/anchor.min.js
new file mode 100644
index 0000000000..1c2b86faed
--- /dev/null
+++ b/stable/site_libs/quarto-html/anchor.min.js
@@ -0,0 +1,9 @@
+// @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat
+//
+// AnchorJS - v4.3.1 - 2021-04-17
+// https://www.bryanbraun.com/anchorjs/
+// Copyright (c) 2021 Bryan Braun; Licensed MIT
+//
+// @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat
+!function(A,e){"use strict";"function"==typeof define&&define.amd?define([],e):"object"==typeof module&&module.exports?module.exports=e():(A.AnchorJS=e(),A.anchors=new A.AnchorJS)}(this,function(){"use strict";return function(A){function d(A){A.icon=Object.prototype.hasOwnProperty.call(A,"icon")?A.icon:"",A.visible=Object.prototype.hasOwnProperty.call(A,"visible")?A.visible:"hover",A.placement=Object.prototype.hasOwnProperty.call(A,"placement")?A.placement:"right",A.ariaLabel=Object.prototype.hasOwnProperty.call(A,"ariaLabel")?A.ariaLabel:"Anchor",A.class=Object.prototype.hasOwnProperty.call(A,"class")?A.class:"",A.base=Object.prototype.hasOwnProperty.call(A,"base")?A.base:"",A.truncate=Object.prototype.hasOwnProperty.call(A,"truncate")?Math.floor(A.truncate):64,A.titleText=Object.prototype.hasOwnProperty.call(A,"titleText")?A.titleText:""}function w(A){var e;if("string"==typeof A||A instanceof String)e=[].slice.call(document.querySelectorAll(A));else{if(!(Array.isArray(A)||A instanceof NodeList))throw new TypeError("The selector provided to AnchorJS was invalid.");e=[].slice.call(A)}return e}this.options=A||{},this.elements=[],d(this.options),this.isTouchDevice=function(){return Boolean("ontouchstart"in window||window.TouchEvent||window.DocumentTouch&&document instanceof DocumentTouch)},this.add=function(A){var e,t,o,i,n,s,a,c,r,l,h,u,p=[];if(d(this.options),"touch"===(l=this.options.visible)&&(l=this.isTouchDevice()?"always":"hover"),0===(e=w(A=A||"h2, h3, h4, h5, h6")).length)return this;for(null===document.head.querySelector("style.anchorjs")&&((u=document.createElement("style")).className="anchorjs",u.appendChild(document.createTextNode("")),void 0===(A=document.head.querySelector('[rel="stylesheet"],style'))?document.head.appendChild(u):document.head.insertBefore(u,A),u.sheet.insertRule(".anchorjs-link{opacity:0;text-decoration:none;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}",u.sheet.cssRules.length),u.sheet.insertRule(":hover>.anchorjs-link,.anchorjs-link:focus{opacity:1}",u.sheet.cssRules.length),u.sheet.insertRule("[data-anchorjs-icon]::after{content:attr(data-anchorjs-icon)}",u.sheet.cssRules.length),u.sheet.insertRule('@font-face{font-family:anchorjs-icons;src:url(data:n/a;base64,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) 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anchorjs-icons","left"===this.options.placement&&(r.style.lineHeight="inherit")),"left"===this.options.placement?(r.style.position="absolute",r.style.marginLeft="-1em",r.style.paddingRight=".5em",e[i].insertBefore(r,e[i].firstChild)):(r.style.paddingLeft=".375em",e[i].appendChild(r))}for(i=0;i<p.length;i++)e.splice(p[i]-i,1);return this.elements=this.elements.concat(e),this},this.remove=function(A){for(var e,t,o=w(A),i=0;i<o.length;i++)(t=o[i].querySelector(".anchorjs-link"))&&(-1!==(e=this.elements.indexOf(o[i]))&&this.elements.splice(e,1),o[i].removeChild(t));return this},this.removeAll=function(){this.remove(this.elements)},this.urlify=function(A){var e=document.createElement("textarea");return e.innerHTML=A,A=e.value,this.options.truncate||d(this.options),A.trim().replace(/'/gi,"").replace(/[& +$,:;=?@"#{}|^~[`%!'<>\]./()*\\\n\t\b\v\u00A0]/g,"-").replace(/-{2,}/g,"-").substring(0,this.options.truncate).replace(/^-+|-+$/gm,"").toLowerCase()},this.hasAnchorJSLink=function(A){var e=A.firstChild&&-1<(" "+A.firstChild.className+" ").indexOf(" anchorjs-link "),A=A.lastChild&&-1<(" "+A.lastChild.className+" ").indexOf(" anchorjs-link ");return e||A||!1}}});
+// @license-end
\ No newline at end of file
diff --git a/stable/site_libs/quarto-html/popper.min.js b/stable/site_libs/quarto-html/popper.min.js
new file mode 100644
index 0000000000..2269d66967
--- /dev/null
+++ b/stable/site_libs/quarto-html/popper.min.js
@@ -0,0 +1,6 @@
+/**
+ * @popperjs/core v2.11.4 - MIT License
+ */
+
+!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?t(exports):"function"==typeof define&&define.amd?define(["exports"],t):t((e="undefined"!=typeof globalThis?globalThis:e||self).Popper={})}(this,(function(e){"use strict";function t(e){if(null==e)return window;if("[object Window]"!==e.toString()){var t=e.ownerDocument;return t&&t.defaultView||window}return e}function n(e){return e instanceof t(e).Element||e instanceof Element}function r(e){return e instanceof t(e).HTMLElement||e instanceof HTMLElement}function o(e){return"undefined"!=typeof ShadowRoot&&(e instanceof t(e).ShadowRoot||e instanceof ShadowRoot)}var i=Math.max,a=Math.min,s=Math.round;function f(e,t){void 0===t&&(t=!1);var n=e.getBoundingClientRect(),o=1,i=1;if(r(e)&&t){var a=e.offsetHeight,f=e.offsetWidth;f>0&&(o=s(n.width)/f||1),a>0&&(i=s(n.height)/a||1)}return{width:n.width/o,height:n.height/i,top:n.top/i,right:n.right/o,bottom:n.bottom/i,left:n.left/o,x:n.left/o,y:n.top/i}}function c(e){var 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Q={passive:!0};var Z={name:"eventListeners",enabled:!0,phase:"write",fn:function(){},effect:function(e){var n=e.state,r=e.instance,o=e.options,i=o.scroll,a=void 0===i||i,s=o.resize,f=void 0===s||s,c=t(n.elements.popper),p=[].concat(n.scrollParents.reference,n.scrollParents.popper);return a&&p.forEach((function(e){e.addEventListener("scroll",r.update,Q)})),f&&c.addEventListener("resize",r.update,Q),function(){a&&p.forEach((function(e){e.removeEventListener("scroll",r.update,Q)})),f&&c.removeEventListener("resize",r.update,Q)}},data:{}};var $={name:"popperOffsets",enabled:!0,phase:"read",fn:function(e){var t=e.state,n=e.name;t.modifiersData[n]=U({reference:t.rects.reference,element:t.rects.popper,strategy:"absolute",placement:t.placement})},data:{}},ee={top:"auto",right:"auto",bottom:"auto",left:"auto"};function te(e){var n,r=e.popper,o=e.popperRect,i=e.placement,a=e.variation,f=e.offsets,c=e.position,p=e.gpuAcceleration,l=e.adaptive,h=e.roundOffsets,m=e.isFixed,v=f.x,g=void 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r>n?n:r}(we,me,Oe):ue(m?we:ge,me,m?Oe:ye);W[k]=je,q[k]=je-me}t.modifiersData[r]=q}},requiresIfExists:["offset"]};var de={name:"arrow",enabled:!0,phase:"main",fn:function(e){var t,n=e.state,r=e.name,o=e.options,i=n.elements.arrow,a=n.modifiersData.popperOffsets,s=C(n.placement),f=F(s),c=[A,D].indexOf(s)>=0?"height":"width";if(i&&a){var p=function(e,t){return z("number"!=typeof(e="function"==typeof e?e(Object.assign({},t.rects,{placement:t.placement})):e)?e:X(e,P))}(o.padding,n),u=v(i),l="y"===f?j:A,d="y"===f?E:D,h=n.rects.reference[c]+n.rects.reference[f]-a[f]-n.rects.popper[c],m=a[f]-n.rects.reference[f],g=O(i),y=g?"y"===f?g.clientHeight||0:g.clientWidth||0:0,b=h/2-m/2,x=p[l],w=y-u[c]-p[d],L=y/2-u[c]/2+b,M=ue(x,L,w),k=f;n.modifiersData[r]=((t={})[k]=M,t.centerOffset=M-L,t)}},effect:function(e){var t=e.state,n=e.options.element,r=void 0===n?"[data-popper-arrow]":n;null!=r&&("string"!=typeof 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+
diff --git a/stable/site_libs/quarto-html/quarto-syntax-highlighting-dark.css b/stable/site_libs/quarto-html/quarto-syntax-highlighting-dark.css
new file mode 100644
index 0000000000..3676fae47b
--- /dev/null
+++ b/stable/site_libs/quarto-html/quarto-syntax-highlighting-dark.css
@@ -0,0 +1,179 @@
+/* quarto syntax highlight colors */
+:root {
+  --quarto-hl-al-color: #ff5555;
+  --quarto-hl-an-color: #6a737d;
+  --quarto-hl-at-color: #f97583;
+  --quarto-hl-bn-color: #79b8ff;
+  --quarto-hl-bu-color: #f97583;
+  --quarto-hl-ch-color: #9ecbff;
+  --quarto-hl-co-color: #6a737d;
+  --quarto-hl-cv-color: #6a737d;
+  --quarto-hl-cn-color: #79b8ff;
+  --quarto-hl-cf-color: #f97583;
+  --quarto-hl-dt-color: #f97583;
+  --quarto-hl-dv-color: #79b8ff;
+  --quarto-hl-do-color: #6a737d;
+  --quarto-hl-er-color: #ff5555;
+  --quarto-hl-ex-color: #f97583;
+  --quarto-hl-fl-color: #79b8ff;
+  --quarto-hl-fu-color: #b392f0;
+  --quarto-hl-im-color: #9ecbff;
+  --quarto-hl-in-color: #6a737d;
+  --quarto-hl-kw-color: #f97583;
+  --quarto-hl-op-color: #e1e4e8;
+  --quarto-hl-pp-color: #f97583;
+  --quarto-hl-re-color: #6a737d;
+  --quarto-hl-sc-color: #79b8ff;
+  --quarto-hl-ss-color: #9ecbff;
+  --quarto-hl-st-color: #9ecbff;
+  --quarto-hl-va-color: #ffab70;
+  --quarto-hl-vs-color: #9ecbff;
+  --quarto-hl-wa-color: #ff5555;
+}
+
+/* other quarto variables */
+:root {
+  --quarto-font-monospace: SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;
+}
+
+code span.al {
+  font-weight: bold;
+  color: #ff5555;
+}
+
+code span.an {
+  color: #6a737d;
+}
+
+code span.at {
+  color: #f97583;
+}
+
+code span.bn {
+  color: #79b8ff;
+}
+
+code span.bu {
+  color: #f97583;
+}
+
+code span.ch {
+  color: #9ecbff;
+}
+
+code span.co {
+  color: #6a737d;
+}
+
+code span.cv {
+  color: #6a737d;
+}
+
+code span.cn {
+  color: #79b8ff;
+}
+
+code span.cf {
+  color: #f97583;
+}
+
+code span.dt {
+  color: #f97583;
+}
+
+code span.dv {
+  color: #79b8ff;
+}
+
+code span.do {
+  color: #6a737d;
+}
+
+code span.er {
+  color: #ff5555;
+  text-decoration: underline;
+}
+
+code span.ex {
+  font-weight: bold;
+  color: #f97583;
+}
+
+code span.fl {
+  color: #79b8ff;
+}
+
+code span.fu {
+  color: #b392f0;
+}
+
+code span.im {
+  color: #9ecbff;
+}
+
+code span.in {
+  color: #6a737d;
+}
+
+code span.kw {
+  color: #f97583;
+}
+
+pre > code.sourceCode > span {
+  color: #e1e4e8;
+}
+
+code span {
+  color: #e1e4e8;
+}
+
+code.sourceCode > span {
+  color: #e1e4e8;
+}
+
+div.sourceCode,
+div.sourceCode pre.sourceCode {
+  color: #e1e4e8;
+}
+
+code span.op {
+  color: #e1e4e8;
+}
+
+code span.pp {
+  color: #f97583;
+}
+
+code span.re {
+  color: #6a737d;
+}
+
+code span.sc {
+  color: #79b8ff;
+}
+
+code span.ss {
+  color: #9ecbff;
+}
+
+code span.st {
+  color: #9ecbff;
+}
+
+code span.va {
+  color: #ffab70;
+}
+
+code span.vs {
+  color: #9ecbff;
+}
+
+code span.wa {
+  color: #ff5555;
+}
+
+.prevent-inlining {
+  content: "</";
+}
+
+/*# sourceMappingURL=935a306eefa94366c21e1a970dddb765.css.map */
diff --git a/stable/site_libs/quarto-html/quarto-syntax-highlighting.css b/stable/site_libs/quarto-html/quarto-syntax-highlighting.css
new file mode 100644
index 0000000000..a3dab6c571
--- /dev/null
+++ b/stable/site_libs/quarto-html/quarto-syntax-highlighting.css
@@ -0,0 +1,179 @@
+/* quarto syntax highlight colors */
+:root {
+  --quarto-hl-al-color: #ff5555;
+  --quarto-hl-an-color: #6a737d;
+  --quarto-hl-at-color: #d73a49;
+  --quarto-hl-bn-color: #005cc5;
+  --quarto-hl-bu-color: #d73a49;
+  --quarto-hl-ch-color: #032f62;
+  --quarto-hl-co-color: #6a737d;
+  --quarto-hl-cv-color: #6a737d;
+  --quarto-hl-cn-color: #005cc5;
+  --quarto-hl-cf-color: #d73a49;
+  --quarto-hl-dt-color: #d73a49;
+  --quarto-hl-dv-color: #005cc5;
+  --quarto-hl-do-color: #6a737d;
+  --quarto-hl-er-color: #ff5555;
+  --quarto-hl-ex-color: #d73a49;
+  --quarto-hl-fl-color: #005cc5;
+  --quarto-hl-fu-color: #6f42c1;
+  --quarto-hl-im-color: #032f62;
+  --quarto-hl-in-color: #6a737d;
+  --quarto-hl-kw-color: #d73a49;
+  --quarto-hl-op-color: #24292e;
+  --quarto-hl-pp-color: #d73a49;
+  --quarto-hl-re-color: #6a737d;
+  --quarto-hl-sc-color: #005cc5;
+  --quarto-hl-ss-color: #032f62;
+  --quarto-hl-st-color: #032f62;
+  --quarto-hl-va-color: #e36209;
+  --quarto-hl-vs-color: #032f62;
+  --quarto-hl-wa-color: #ff5555;
+}
+
+/* other quarto variables */
+:root {
+  --quarto-font-monospace: SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;
+}
+
+code span.al {
+  font-weight: bold;
+  color: #ff5555;
+}
+
+code span.an {
+  color: #6a737d;
+}
+
+code span.at {
+  color: #d73a49;
+}
+
+code span.bn {
+  color: #005cc5;
+}
+
+code span.bu {
+  color: #d73a49;
+}
+
+code span.ch {
+  color: #032f62;
+}
+
+code span.co {
+  color: #6a737d;
+}
+
+code span.cv {
+  color: #6a737d;
+}
+
+code span.cn {
+  color: #005cc5;
+}
+
+code span.cf {
+  color: #d73a49;
+}
+
+code span.dt {
+  color: #d73a49;
+}
+
+code span.dv {
+  color: #005cc5;
+}
+
+code span.do {
+  color: #6a737d;
+}
+
+code span.er {
+  color: #ff5555;
+  text-decoration: underline;
+}
+
+code span.ex {
+  font-weight: bold;
+  color: #d73a49;
+}
+
+code span.fl {
+  color: #005cc5;
+}
+
+code span.fu {
+  color: #6f42c1;
+}
+
+code span.im {
+  color: #032f62;
+}
+
+code span.in {
+  color: #6a737d;
+}
+
+code span.kw {
+  color: #d73a49;
+}
+
+pre > code.sourceCode > span {
+  color: #24292e;
+}
+
+code span {
+  color: #24292e;
+}
+
+code.sourceCode > span {
+  color: #24292e;
+}
+
+div.sourceCode,
+div.sourceCode pre.sourceCode {
+  color: #24292e;
+}
+
+code span.op {
+  color: #24292e;
+}
+
+code span.pp {
+  color: #d73a49;
+}
+
+code span.re {
+  color: #6a737d;
+}
+
+code span.sc {
+  color: #005cc5;
+}
+
+code span.ss {
+  color: #032f62;
+}
+
+code span.st {
+  color: #032f62;
+}
+
+code span.va {
+  color: #e36209;
+}
+
+code span.vs {
+  color: #032f62;
+}
+
+code span.wa {
+  color: #ff5555;
+}
+
+.prevent-inlining {
+  content: "</";
+}
+
+/*# sourceMappingURL=debc5d5d77c3f9108843748ff7464032.css.map */
diff --git a/stable/site_libs/quarto-html/quarto.js b/stable/site_libs/quarto-html/quarto.js
new file mode 100644
index 0000000000..c3935c7e50
--- /dev/null
+++ b/stable/site_libs/quarto-html/quarto.js
@@ -0,0 +1,902 @@
+const sectionChanged = new CustomEvent("quarto-sectionChanged", {
+  detail: {},
+  bubbles: true,
+  cancelable: false,
+  composed: false,
+});
+
+const layoutMarginEls = () => {
+  // Find any conflicting margin elements and add margins to the
+  // top to prevent overlap
+  const marginChildren = window.document.querySelectorAll(
+    ".column-margin.column-container > * "
+  );
+
+  let lastBottom = 0;
+  for (const marginChild of marginChildren) {
+    if (marginChild.offsetParent !== null) {
+      // clear the top margin so we recompute it
+      marginChild.style.marginTop = null;
+      const top = marginChild.getBoundingClientRect().top + window.scrollY;
+      console.log({
+        childtop: marginChild.getBoundingClientRect().top,
+        scroll: window.scrollY,
+        top,
+        lastBottom,
+      });
+      if (top < lastBottom) {
+        const margin = lastBottom - top;
+        marginChild.style.marginTop = `${margin}px`;
+      }
+      const styles = window.getComputedStyle(marginChild);
+      const marginTop = parseFloat(styles["marginTop"]);
+
+      console.log({
+        top,
+        height: marginChild.getBoundingClientRect().height,
+        marginTop,
+        total: top + marginChild.getBoundingClientRect().height + marginTop,
+      });
+      lastBottom = top + marginChild.getBoundingClientRect().height + marginTop;
+    }
+  }
+};
+
+window.document.addEventListener("DOMContentLoaded", function (_event) {
+  // Recompute the position of margin elements anytime the body size changes
+  if (window.ResizeObserver) {
+    const resizeObserver = new window.ResizeObserver(
+      throttle(layoutMarginEls, 50)
+    );
+    resizeObserver.observe(window.document.body);
+  }
+
+  const tocEl = window.document.querySelector('nav.toc-active[role="doc-toc"]');
+  const sidebarEl = window.document.getElementById("quarto-sidebar");
+  const leftTocEl = window.document.getElementById("quarto-sidebar-toc-left");
+  const marginSidebarEl = window.document.getElementById(
+    "quarto-margin-sidebar"
+  );
+  // function to determine whether the element has a previous sibling that is active
+  const prevSiblingIsActiveLink = (el) => {
+    const sibling = el.previousElementSibling;
+    if (sibling && sibling.tagName === "A") {
+      return sibling.classList.contains("active");
+    } else {
+      return false;
+    }
+  };
+
+  // fire slideEnter for bootstrap tab activations (for htmlwidget resize behavior)
+  function fireSlideEnter(e) {
+    const event = window.document.createEvent("Event");
+    event.initEvent("slideenter", true, true);
+    window.document.dispatchEvent(event);
+  }
+  const tabs = window.document.querySelectorAll('a[data-bs-toggle="tab"]');
+  tabs.forEach((tab) => {
+    tab.addEventListener("shown.bs.tab", fireSlideEnter);
+  });
+
+  // fire slideEnter for tabby tab activations (for htmlwidget resize behavior)
+  document.addEventListener("tabby", fireSlideEnter, false);
+
+  // Track scrolling and mark TOC links as active
+  // get table of contents and sidebar (bail if we don't have at least one)
+  const tocLinks = tocEl
+    ? [...tocEl.querySelectorAll("a[data-scroll-target]")]
+    : [];
+  const makeActive = (link) => tocLinks[link].classList.add("active");
+  const removeActive = (link) => tocLinks[link].classList.remove("active");
+  const removeAllActive = () =>
+    [...Array(tocLinks.length).keys()].forEach((link) => removeActive(link));
+
+  // activate the anchor for a section associated with this TOC entry
+  tocLinks.forEach((link) => {
+    link.addEventListener("click", () => {
+      if (link.href.indexOf("#") !== -1) {
+        const anchor = link.href.split("#")[1];
+        const heading = window.document.querySelector(
+          `[data-anchor-id=${anchor}]`
+        );
+        if (heading) {
+          // Add the class
+          heading.classList.add("reveal-anchorjs-link");
+
+          // function to show the anchor
+          const handleMouseout = () => {
+            heading.classList.remove("reveal-anchorjs-link");
+            heading.removeEventListener("mouseout", handleMouseout);
+          };
+
+          // add a function to clear the anchor when the user mouses out of it
+          heading.addEventListener("mouseout", handleMouseout);
+        }
+      }
+    });
+  });
+
+  const sections = tocLinks.map((link) => {
+    const target = link.getAttribute("data-scroll-target");
+    if (target.startsWith("#")) {
+      return window.document.getElementById(decodeURI(`${target.slice(1)}`));
+    } else {
+      return window.document.querySelector(decodeURI(`${target}`));
+    }
+  });
+
+  const sectionMargin = 200;
+  let currentActive = 0;
+  // track whether we've initialized state the first time
+  let init = false;
+
+  const updateActiveLink = () => {
+    // The index from bottom to top (e.g. reversed list)
+    let sectionIndex = -1;
+    if (
+      window.innerHeight + window.pageYOffset >=
+      window.document.body.offsetHeight
+    ) {
+      sectionIndex = 0;
+    } else {
+      sectionIndex = [...sections].reverse().findIndex((section) => {
+        if (section) {
+          return window.pageYOffset >= section.offsetTop - sectionMargin;
+        } else {
+          return false;
+        }
+      });
+    }
+    if (sectionIndex > -1) {
+      const current = sections.length - sectionIndex - 1;
+      if (current !== currentActive) {
+        removeAllActive();
+        currentActive = current;
+        makeActive(current);
+        if (init) {
+          window.dispatchEvent(sectionChanged);
+        }
+        init = true;
+      }
+    }
+  };
+
+  const inHiddenRegion = (top, bottom, hiddenRegions) => {
+    for (const region of hiddenRegions) {
+      if (top <= region.bottom && bottom >= region.top) {
+        return true;
+      }
+    }
+    return false;
+  };
+
+  const categorySelector = "header.quarto-title-block .quarto-category";
+  const activateCategories = (href) => {
+    // Find any categories
+    // Surround them with a link pointing back to:
+    // #category=Authoring
+    try {
+      const categoryEls = window.document.querySelectorAll(categorySelector);
+      for (const categoryEl of categoryEls) {
+        const categoryText = categoryEl.textContent;
+        if (categoryText) {
+          const link = `${href}#category=${encodeURIComponent(categoryText)}`;
+          const linkEl = window.document.createElement("a");
+          linkEl.setAttribute("href", link);
+          for (const child of categoryEl.childNodes) {
+            linkEl.append(child);
+          }
+          categoryEl.appendChild(linkEl);
+        }
+      }
+    } catch {
+      // Ignore errors
+    }
+  };
+  function hasTitleCategories() {
+    return window.document.querySelector(categorySelector) !== null;
+  }
+
+  function offsetRelativeUrl(url) {
+    const offset = getMeta("quarto:offset");
+    return offset ? offset + url : url;
+  }
+
+  function offsetAbsoluteUrl(url) {
+    const offset = getMeta("quarto:offset");
+    const baseUrl = new URL(offset, window.location);
+
+    const projRelativeUrl = url.replace(baseUrl, "");
+    if (projRelativeUrl.startsWith("/")) {
+      return projRelativeUrl;
+    } else {
+      return "/" + projRelativeUrl;
+    }
+  }
+
+  // read a meta tag value
+  function getMeta(metaName) {
+    const metas = window.document.getElementsByTagName("meta");
+    for (let i = 0; i < metas.length; i++) {
+      if (metas[i].getAttribute("name") === metaName) {
+        return metas[i].getAttribute("content");
+      }
+    }
+    return "";
+  }
+
+  async function findAndActivateCategories() {
+    const currentPagePath = offsetAbsoluteUrl(window.location.href);
+    const response = await fetch(offsetRelativeUrl("listings.json"));
+    if (response.status == 200) {
+      return response.json().then(function (listingPaths) {
+        const listingHrefs = [];
+        for (const listingPath of listingPaths) {
+          const pathWithoutLeadingSlash = listingPath.listing.substring(1);
+          for (const item of listingPath.items) {
+            if (
+              item === currentPagePath ||
+              item === currentPagePath + "index.html"
+            ) {
+              // Resolve this path against the offset to be sure
+              // we already are using the correct path to the listing
+              // (this adjusts the listing urls to be rooted against
+              // whatever root the page is actually running against)
+              const relative = offsetRelativeUrl(pathWithoutLeadingSlash);
+              const baseUrl = window.location;
+              const resolvedPath = new URL(relative, baseUrl);
+              listingHrefs.push(resolvedPath.pathname);
+              break;
+            }
+          }
+        }
+
+        // Look up the tree for a nearby linting and use that if we find one
+        const nearestListing = findNearestParentListing(
+          offsetAbsoluteUrl(window.location.pathname),
+          listingHrefs
+        );
+        if (nearestListing) {
+          activateCategories(nearestListing);
+        } else {
+          // See if the referrer is a listing page for this item
+          const referredRelativePath = offsetAbsoluteUrl(document.referrer);
+          const referrerListing = listingHrefs.find((listingHref) => {
+            const isListingReferrer =
+              listingHref === referredRelativePath ||
+              listingHref === referredRelativePath + "index.html";
+            return isListingReferrer;
+          });
+
+          if (referrerListing) {
+            // Try to use the referrer if possible
+            activateCategories(referrerListing);
+          } else if (listingHrefs.length > 0) {
+            // Otherwise, just fall back to the first listing
+            activateCategories(listingHrefs[0]);
+          }
+        }
+      });
+    }
+  }
+  if (hasTitleCategories()) {
+    findAndActivateCategories();
+  }
+
+  const findNearestParentListing = (href, listingHrefs) => {
+    if (!href || !listingHrefs) {
+      return undefined;
+    }
+    // Look up the tree for a nearby linting and use that if we find one
+    const relativeParts = href.substring(1).split("/");
+    while (relativeParts.length > 0) {
+      const path = relativeParts.join("/");
+      for (const listingHref of listingHrefs) {
+        if (listingHref.startsWith(path)) {
+          return listingHref;
+        }
+      }
+      relativeParts.pop();
+    }
+
+    return undefined;
+  };
+
+  const manageSidebarVisiblity = (el, placeholderDescriptor) => {
+    let isVisible = true;
+    let elRect;
+
+    return (hiddenRegions) => {
+      if (el === null) {
+        return;
+      }
+
+      // Find the last element of the TOC
+      const lastChildEl = el.lastElementChild;
+
+      if (lastChildEl) {
+        // Converts the sidebar to a menu
+        const convertToMenu = () => {
+          for (const child of el.children) {
+            child.style.opacity = 0;
+            child.style.overflow = "hidden";
+          }
+
+          nexttick(() => {
+            const toggleContainer = window.document.createElement("div");
+            toggleContainer.style.width = "100%";
+            toggleContainer.classList.add("zindex-over-content");
+            toggleContainer.classList.add("quarto-sidebar-toggle");
+            toggleContainer.classList.add("headroom-target"); // Marks this to be managed by headeroom
+            toggleContainer.id = placeholderDescriptor.id;
+            toggleContainer.style.position = "fixed";
+
+            const toggleIcon = window.document.createElement("i");
+            toggleIcon.classList.add("quarto-sidebar-toggle-icon");
+            toggleIcon.classList.add("bi");
+            toggleIcon.classList.add("bi-caret-down-fill");
+
+            const toggleTitle = window.document.createElement("div");
+            const titleEl = window.document.body.querySelector(
+              placeholderDescriptor.titleSelector
+            );
+            if (titleEl) {
+              toggleTitle.append(
+                titleEl.textContent || titleEl.innerText,
+                toggleIcon
+              );
+            }
+            toggleTitle.classList.add("zindex-over-content");
+            toggleTitle.classList.add("quarto-sidebar-toggle-title");
+            toggleContainer.append(toggleTitle);
+
+            const toggleContents = window.document.createElement("div");
+            toggleContents.classList = el.classList;
+            toggleContents.classList.add("zindex-over-content");
+            toggleContents.classList.add("quarto-sidebar-toggle-contents");
+            for (const child of el.children) {
+              if (child.id === "toc-title") {
+                continue;
+              }
+
+              const clone = child.cloneNode(true);
+              clone.style.opacity = 1;
+              clone.style.display = null;
+              toggleContents.append(clone);
+            }
+            toggleContents.style.height = "0px";
+            const positionToggle = () => {
+              // position the element (top left of parent, same width as parent)
+              if (!elRect) {
+                elRect = el.getBoundingClientRect();
+              }
+              toggleContainer.style.left = `${elRect.left}px`;
+              toggleContainer.style.top = `${elRect.top}px`;
+              toggleContainer.style.width = `${elRect.width}px`;
+            };
+            positionToggle();
+
+            toggleContainer.append(toggleContents);
+            el.parentElement.prepend(toggleContainer);
+
+            // Process clicks
+            let tocShowing = false;
+            // Allow the caller to control whether this is dismissed
+            // when it is clicked (e.g. sidebar navigation supports
+            // opening and closing the nav tree, so don't dismiss on click)
+            const clickEl = placeholderDescriptor.dismissOnClick
+              ? toggleContainer
+              : toggleTitle;
+
+            const closeToggle = () => {
+              if (tocShowing) {
+                toggleContainer.classList.remove("expanded");
+                toggleContents.style.height = "0px";
+                tocShowing = false;
+              }
+            };
+
+            // Get rid of any expanded toggle if the user scrolls
+            window.document.addEventListener(
+              "scroll",
+              throttle(() => {
+                closeToggle();
+              }, 50)
+            );
+
+            // Handle positioning of the toggle
+            window.addEventListener(
+              "resize",
+              throttle(() => {
+                elRect = undefined;
+                positionToggle();
+              }, 50)
+            );
+
+            window.addEventListener("quarto-hrChanged", () => {
+              elRect = undefined;
+            });
+
+            // Process the click
+            clickEl.onclick = () => {
+              if (!tocShowing) {
+                toggleContainer.classList.add("expanded");
+                toggleContents.style.height = null;
+                tocShowing = true;
+              } else {
+                closeToggle();
+              }
+            };
+          });
+        };
+
+        // Converts a sidebar from a menu back to a sidebar
+        const convertToSidebar = () => {
+          for (const child of el.children) {
+            child.style.opacity = 1;
+            child.style.overflow = null;
+          }
+
+          const placeholderEl = window.document.getElementById(
+            placeholderDescriptor.id
+          );
+          if (placeholderEl) {
+            placeholderEl.remove();
+          }
+
+          el.classList.remove("rollup");
+        };
+
+        if (isReaderMode()) {
+          convertToMenu();
+          isVisible = false;
+        } else {
+          // Find the top and bottom o the element that is being managed
+          const elTop = el.offsetTop;
+          const elBottom =
+            elTop + lastChildEl.offsetTop + lastChildEl.offsetHeight;
+
+          if (!isVisible) {
+            // If the element is current not visible reveal if there are
+            // no conflicts with overlay regions
+            if (!inHiddenRegion(elTop, elBottom, hiddenRegions)) {
+              convertToSidebar();
+              isVisible = true;
+            }
+          } else {
+            // If the element is visible, hide it if it conflicts with overlay regions
+            // and insert a placeholder toggle (or if we're in reader mode)
+            if (inHiddenRegion(elTop, elBottom, hiddenRegions)) {
+              convertToMenu();
+              isVisible = false;
+            }
+          }
+        }
+      }
+    };
+  };
+
+  const tabEls = document.querySelectorAll('a[data-bs-toggle="tab"]');
+  for (const tabEl of tabEls) {
+    const id = tabEl.getAttribute("data-bs-target");
+    if (id) {
+      const columnEl = document.querySelector(
+        `${id} .column-margin, .tabset-margin-content`
+      );
+      if (columnEl)
+        tabEl.addEventListener("shown.bs.tab", function (event) {
+          const el = event.srcElement;
+          if (el) {
+            const visibleCls = `${el.id}-margin-content`;
+            // walk up until we find a parent tabset
+            let panelTabsetEl = el.parentElement;
+            while (panelTabsetEl) {
+              if (panelTabsetEl.classList.contains("panel-tabset")) {
+                break;
+              }
+              panelTabsetEl = panelTabsetEl.parentElement;
+            }
+
+            if (panelTabsetEl) {
+              const prevSib = panelTabsetEl.previousElementSibling;
+              if (
+                prevSib &&
+                prevSib.classList.contains("tabset-margin-container")
+              ) {
+                const childNodes = prevSib.querySelectorAll(
+                  ".tabset-margin-content"
+                );
+                for (const childEl of childNodes) {
+                  if (childEl.classList.contains(visibleCls)) {
+                    childEl.classList.remove("collapse");
+                  } else {
+                    childEl.classList.add("collapse");
+                  }
+                }
+              }
+            }
+          }
+
+          layoutMarginEls();
+        });
+    }
+  }
+
+  // Manage the visibility of the toc and the sidebar
+  const marginScrollVisibility = manageSidebarVisiblity(marginSidebarEl, {
+    id: "quarto-toc-toggle",
+    titleSelector: "#toc-title",
+    dismissOnClick: true,
+  });
+  const sidebarScrollVisiblity = manageSidebarVisiblity(sidebarEl, {
+    id: "quarto-sidebarnav-toggle",
+    titleSelector: ".title",
+    dismissOnClick: false,
+  });
+  let tocLeftScrollVisibility;
+  if (leftTocEl) {
+    tocLeftScrollVisibility = manageSidebarVisiblity(leftTocEl, {
+      id: "quarto-lefttoc-toggle",
+      titleSelector: "#toc-title",
+      dismissOnClick: true,
+    });
+  }
+
+  // Find the first element that uses formatting in special columns
+  const conflictingEls = window.document.body.querySelectorAll(
+    '[class^="column-"], [class*=" column-"], aside, [class*="margin-caption"], [class*=" margin-caption"], [class*="margin-ref"], [class*=" margin-ref"]'
+  );
+
+  // Filter all the possibly conflicting elements into ones
+  // the do conflict on the left or ride side
+  const arrConflictingEls = Array.from(conflictingEls);
+  const leftSideConflictEls = arrConflictingEls.filter((el) => {
+    if (el.tagName === "ASIDE") {
+      return false;
+    }
+    return Array.from(el.classList).find((className) => {
+      return (
+        className !== "column-body" &&
+        className.startsWith("column-") &&
+        !className.endsWith("right") &&
+        !className.endsWith("container") &&
+        className !== "column-margin"
+      );
+    });
+  });
+  const rightSideConflictEls = arrConflictingEls.filter((el) => {
+    if (el.tagName === "ASIDE") {
+      return true;
+    }
+
+    const hasMarginCaption = Array.from(el.classList).find((className) => {
+      return className == "margin-caption";
+    });
+    if (hasMarginCaption) {
+      return true;
+    }
+
+    return Array.from(el.classList).find((className) => {
+      return (
+        className !== "column-body" &&
+        !className.endsWith("container") &&
+        className.startsWith("column-") &&
+        !className.endsWith("left")
+      );
+    });
+  });
+
+  const kOverlapPaddingSize = 10;
+  function toRegions(els) {
+    return els.map((el) => {
+      const boundRect = el.getBoundingClientRect();
+      const top =
+        boundRect.top +
+        document.documentElement.scrollTop -
+        kOverlapPaddingSize;
+      return {
+        top,
+        bottom: top + el.scrollHeight + 2 * kOverlapPaddingSize,
+      };
+    });
+  }
+
+  let hasObserved = false;
+  const visibleItemObserver = (els) => {
+    let visibleElements = [...els];
+    const intersectionObserver = new IntersectionObserver(
+      (entries, _observer) => {
+        entries.forEach((entry) => {
+          if (entry.isIntersecting) {
+            if (visibleElements.indexOf(entry.target) === -1) {
+              visibleElements.push(entry.target);
+            }
+          } else {
+            visibleElements = visibleElements.filter((visibleEntry) => {
+              return visibleEntry !== entry;
+            });
+          }
+        });
+
+        if (!hasObserved) {
+          hideOverlappedSidebars();
+        }
+        hasObserved = true;
+      },
+      {}
+    );
+    els.forEach((el) => {
+      intersectionObserver.observe(el);
+    });
+
+    return {
+      getVisibleEntries: () => {
+        return visibleElements;
+      },
+    };
+  };
+
+  const rightElementObserver = visibleItemObserver(rightSideConflictEls);
+  const leftElementObserver = visibleItemObserver(leftSideConflictEls);
+
+  const hideOverlappedSidebars = () => {
+    marginScrollVisibility(toRegions(rightElementObserver.getVisibleEntries()));
+    sidebarScrollVisiblity(toRegions(leftElementObserver.getVisibleEntries()));
+    if (tocLeftScrollVisibility) {
+      tocLeftScrollVisibility(
+        toRegions(leftElementObserver.getVisibleEntries())
+      );
+    }
+  };
+
+  window.quartoToggleReader = () => {
+    // Applies a slow class (or removes it)
+    // to update the transition speed
+    const slowTransition = (slow) => {
+      const manageTransition = (id, slow) => {
+        const el = document.getElementById(id);
+        if (el) {
+          if (slow) {
+            el.classList.add("slow");
+          } else {
+            el.classList.remove("slow");
+          }
+        }
+      };
+
+      manageTransition("TOC", slow);
+      manageTransition("quarto-sidebar", slow);
+    };
+    const readerMode = !isReaderMode();
+    setReaderModeValue(readerMode);
+
+    // If we're entering reader mode, slow the transition
+    if (readerMode) {
+      slowTransition(readerMode);
+    }
+    highlightReaderToggle(readerMode);
+    hideOverlappedSidebars();
+
+    // If we're exiting reader mode, restore the non-slow transition
+    if (!readerMode) {
+      slowTransition(!readerMode);
+    }
+  };
+
+  const highlightReaderToggle = (readerMode) => {
+    const els = document.querySelectorAll(".quarto-reader-toggle");
+    if (els) {
+      els.forEach((el) => {
+        if (readerMode) {
+          el.classList.add("reader");
+        } else {
+          el.classList.remove("reader");
+        }
+      });
+    }
+  };
+
+  const setReaderModeValue = (val) => {
+    if (window.location.protocol !== "file:") {
+      window.localStorage.setItem("quarto-reader-mode", val);
+    } else {
+      localReaderMode = val;
+    }
+  };
+
+  const isReaderMode = () => {
+    if (window.location.protocol !== "file:") {
+      return window.localStorage.getItem("quarto-reader-mode") === "true";
+    } else {
+      return localReaderMode;
+    }
+  };
+  let localReaderMode = null;
+
+  const tocOpenDepthStr = tocEl?.getAttribute("data-toc-expanded");
+  const tocOpenDepth = tocOpenDepthStr ? Number(tocOpenDepthStr) : 1;
+
+  // Walk the TOC and collapse/expand nodes
+  // Nodes are expanded if:
+  // - they are top level
+  // - they have children that are 'active' links
+  // - they are directly below an link that is 'active'
+  const walk = (el, depth) => {
+    // Tick depth when we enter a UL
+    if (el.tagName === "UL") {
+      depth = depth + 1;
+    }
+
+    // It this is active link
+    let isActiveNode = false;
+    if (el.tagName === "A" && el.classList.contains("active")) {
+      isActiveNode = true;
+    }
+
+    // See if there is an active child to this element
+    let hasActiveChild = false;
+    for (child of el.children) {
+      hasActiveChild = walk(child, depth) || hasActiveChild;
+    }
+
+    // Process the collapse state if this is an UL
+    if (el.tagName === "UL") {
+      if (tocOpenDepth === -1 && depth > 1) {
+        el.classList.add("collapse");
+      } else if (
+        depth <= tocOpenDepth ||
+        hasActiveChild ||
+        prevSiblingIsActiveLink(el)
+      ) {
+        el.classList.remove("collapse");
+      } else {
+        el.classList.add("collapse");
+      }
+
+      // untick depth when we leave a UL
+      depth = depth - 1;
+    }
+    return hasActiveChild || isActiveNode;
+  };
+
+  // walk the TOC and expand / collapse any items that should be shown
+
+  if (tocEl) {
+    walk(tocEl, 0);
+    updateActiveLink();
+  }
+
+  // Throttle the scroll event and walk peridiocally
+  window.document.addEventListener(
+    "scroll",
+    throttle(() => {
+      if (tocEl) {
+        updateActiveLink();
+        walk(tocEl, 0);
+      }
+      if (!isReaderMode()) {
+        hideOverlappedSidebars();
+      }
+    }, 5)
+  );
+  window.addEventListener(
+    "resize",
+    throttle(() => {
+      if (!isReaderMode()) {
+        hideOverlappedSidebars();
+      }
+    }, 10)
+  );
+  hideOverlappedSidebars();
+  highlightReaderToggle(isReaderMode());
+});
+
+// grouped tabsets
+window.addEventListener("pageshow", (_event) => {
+  function getTabSettings() {
+    const data = localStorage.getItem("quarto-persistent-tabsets-data");
+    if (!data) {
+      localStorage.setItem("quarto-persistent-tabsets-data", "{}");
+      return {};
+    }
+    if (data) {
+      return JSON.parse(data);
+    }
+  }
+
+  function setTabSettings(data) {
+    localStorage.setItem(
+      "quarto-persistent-tabsets-data",
+      JSON.stringify(data)
+    );
+  }
+
+  function setTabState(groupName, groupValue) {
+    const data = getTabSettings();
+    data[groupName] = groupValue;
+    setTabSettings(data);
+  }
+
+  function toggleTab(tab, active) {
+    const tabPanelId = tab.getAttribute("aria-controls");
+    const tabPanel = document.getElementById(tabPanelId);
+    if (active) {
+      tab.classList.add("active");
+      tabPanel.classList.add("active");
+    } else {
+      tab.classList.remove("active");
+      tabPanel.classList.remove("active");
+    }
+  }
+
+  function toggleAll(selectedGroup, selectorsToSync) {
+    for (const [thisGroup, tabs] of Object.entries(selectorsToSync)) {
+      const active = selectedGroup === thisGroup;
+      for (const tab of tabs) {
+        toggleTab(tab, active);
+      }
+    }
+  }
+
+  function findSelectorsToSyncByLanguage() {
+    const result = {};
+    const tabs = Array.from(
+      document.querySelectorAll(`div[data-group] a[id^='tabset-']`)
+    );
+    for (const item of tabs) {
+      const div = item.parentElement.parentElement.parentElement;
+      const group = div.getAttribute("data-group");
+      if (!result[group]) {
+        result[group] = {};
+      }
+      const selectorsToSync = result[group];
+      const value = item.innerHTML;
+      if (!selectorsToSync[value]) {
+        selectorsToSync[value] = [];
+      }
+      selectorsToSync[value].push(item);
+    }
+    return result;
+  }
+
+  function setupSelectorSync() {
+    const selectorsToSync = findSelectorsToSyncByLanguage();
+    Object.entries(selectorsToSync).forEach(([group, tabSetsByValue]) => {
+      Object.entries(tabSetsByValue).forEach(([value, items]) => {
+        items.forEach((item) => {
+          item.addEventListener("click", (_event) => {
+            setTabState(group, value);
+            toggleAll(value, selectorsToSync[group]);
+          });
+        });
+      });
+    });
+    return selectorsToSync;
+  }
+
+  const selectorsToSync = setupSelectorSync();
+  for (const [group, selectedName] of Object.entries(getTabSettings())) {
+    const selectors = selectorsToSync[group];
+    // it's possible that stale state gives us empty selections, so we explicitly check here.
+    if (selectors) {
+      toggleAll(selectedName, selectors);
+    }
+  }
+});
+
+function throttle(func, wait) {
+  let waiting = false;
+  return function () {
+    if (!waiting) {
+      func.apply(this, arguments);
+      waiting = true;
+      setTimeout(function () {
+        waiting = false;
+      }, wait);
+    }
+  };
+}
+
+function nexttick(func) {
+  return setTimeout(func, 0);
+}
diff --git a/stable/site_libs/quarto-html/tippy.css b/stable/site_libs/quarto-html/tippy.css
new file mode 100644
index 0000000000..e6ae635cb1
--- /dev/null
+++ b/stable/site_libs/quarto-html/tippy.css
@@ -0,0 +1 @@
+.tippy-box[data-animation=fade][data-state=hidden]{opacity:0}[data-tippy-root]{max-width:calc(100vw - 10px)}.tippy-box{position:relative;background-color:#333;color:#fff;border-radius:4px;font-size:14px;line-height:1.4;white-space:normal;outline:0;transition-property:transform,visibility,opacity}.tippy-box[data-placement^=top]>.tippy-arrow{bottom:0}.tippy-box[data-placement^=top]>.tippy-arrow:before{bottom:-7px;left:0;border-width:8px 8px 0;border-top-color:initial;transform-origin:center top}.tippy-box[data-placement^=bottom]>.tippy-arrow{top:0}.tippy-box[data-placement^=bottom]>.tippy-arrow:before{top:-7px;left:0;border-width:0 8px 8px;border-bottom-color:initial;transform-origin:center bottom}.tippy-box[data-placement^=left]>.tippy-arrow{right:0}.tippy-box[data-placement^=left]>.tippy-arrow:before{border-width:8px 0 8px 8px;border-left-color:initial;right:-7px;transform-origin:center left}.tippy-box[data-placement^=right]>.tippy-arrow{left:0}.tippy-box[data-placement^=right]>.tippy-arrow:before{left:-7px;border-width:8px 8px 8px 0;border-right-color:initial;transform-origin:center right}.tippy-box[data-inertia][data-state=visible]{transition-timing-function:cubic-bezier(.54,1.5,.38,1.11)}.tippy-arrow{width:16px;height:16px;color:#333}.tippy-arrow:before{content:"";position:absolute;border-color:transparent;border-style:solid}.tippy-content{position:relative;padding:5px 9px;z-index:1}
\ No newline at end of file
diff --git a/stable/site_libs/quarto-html/tippy.umd.min.js b/stable/site_libs/quarto-html/tippy.umd.min.js
new file mode 100644
index 0000000000..ca292be32b
--- /dev/null
+++ b/stable/site_libs/quarto-html/tippy.umd.min.js
@@ -0,0 +1,2 @@
+!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?module.exports=t(require("@popperjs/core")):"function"==typeof define&&define.amd?define(["@popperjs/core"],t):(e=e||self).tippy=t(e.Popper)}(this,(function(e){"use strict";var t={passive:!0,capture:!0},n=function(){return document.body};function r(e,t,n){if(Array.isArray(e)){var r=e[t];return null==r?Array.isArray(n)?n[t]:n:r}return e}function o(e,t){var n={}.toString.call(e);return 0===n.indexOf("[object")&&n.indexOf(t+"]")>-1}function i(e,t){return"function"==typeof e?e.apply(void 0,t):e}function a(e,t){return 0===t?e:function(r){clearTimeout(n),n=setTimeout((function(){e(r)}),t)};var n}function s(e,t){var n=Object.assign({},e);return t.forEach((function(e){delete n[e]})),n}function u(e){return[].concat(e)}function c(e,t){-1===e.indexOf(t)&&e.push(t)}function p(e){return e.split("-")[0]}function f(e){return[].slice.call(e)}function l(e){return Object.keys(e).reduce((function(t,n){return void 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diff --git a/stable/site_libs/quarto-html/zenscroll-min.js b/stable/site_libs/quarto-html/zenscroll-min.js
new file mode 100644
index 0000000000..694d9d8b9d
--- /dev/null
+++ b/stable/site_libs/quarto-html/zenscroll-min.js
@@ -0,0 +1 @@
+!function(t,e){"function"==typeof define&&define.amd?define([],e()):"object"==typeof module&&module.exports?module.exports=e():function n(){document&&document.body?t.zenscroll=e():setTimeout(n,9)}()}(this,function(){"use strict";var t=function(t){return t&&"getComputedStyle"in window&&"smooth"===window.getComputedStyle(t)["scroll-behavior"]};if("undefined"==typeof window||!("document"in window))return{};var e=function(e,n,o){n=n||999,o||0===o||(o=9);var i,r=function(t){i=t},u=function(){clearTimeout(i),r(0)},c=function(t){return Math.max(0,e.getTopOf(t)-o)},a=function(o,i,c){if(u(),0===i||i&&i<0||t(e.body))e.toY(o),c&&c();else{var a=e.getY(),f=Math.max(0,o)-a,s=(new Date).getTime();i=i||Math.min(Math.abs(f),n),function t(){r(setTimeout(function(){var n=Math.min(1,((new Date).getTime()-s)/i),o=Math.max(0,Math.floor(a+f*(n<.5?2*n*n:n*(4-2*n)-1)));e.toY(o),n<1&&e.getHeight()+o<e.body.scrollHeight?t():(setTimeout(u,99),c&&c())},9))}()}},f=function(t,e,n){a(c(t),e,n)},s=function(t,n,i){var r=t.getBoundingClientRect().height,u=e.getTopOf(t)+r,s=e.getHeight(),l=e.getY(),d=l+s;c(t)<l||r+o>s?f(t,n,i):u+o>d?a(u-s+o,n,i):i&&i()},l=function(t,n,o,i){a(Math.max(0,e.getTopOf(t)-e.getHeight()/2+(o||t.getBoundingClientRect().height/2)),n,i)};return{setup:function(t,e){return(0===t||t)&&(n=t),(0===e||e)&&(o=e),{defaultDuration:n,edgeOffset:o}},to:f,toY:a,intoView:s,center:l,stop:u,moving:function(){return!!i},getY:e.getY,getTopOf:e.getTopOf}},n=document.documentElement,o=function(){return window.scrollY||n.scrollTop},i=e({body:document.scrollingElement||document.body,toY:function(t){window.scrollTo(0,t)},getY:o,getHeight:function(){return window.innerHeight||n.clientHeight},getTopOf:function(t){return t.getBoundingClientRect().top+o()-n.offsetTop}});if(i.createScroller=function(t,o,i){return e({body:t,toY:function(e){t.scrollTop=e},getY:function(){return t.scrollTop},getHeight:function(){return Math.min(t.clientHeight,window.innerHeight||n.clientHeight)},getTopOf:function(t){return t.offsetTop}},o,i)},"addEventListener"in window&&!window.noZensmooth&&!t(document.body)){var r="history"in window&&"pushState"in history,u=r&&"scrollRestoration"in history;u&&(history.scrollRestoration="auto"),window.addEventListener("load",function(){u&&(setTimeout(function(){history.scrollRestoration="manual"},9),window.addEventListener("popstate",function(t){t.state&&"zenscrollY"in t.state&&i.toY(t.state.zenscrollY)},!1)),window.location.hash&&setTimeout(function(){var t=i.setup().edgeOffset;if(t){var e=document.getElementById(window.location.href.split("#")[1]);if(e){var n=Math.max(0,i.getTopOf(e)-t),o=i.getY()-n;0<=o&&o<9&&window.scrollTo(0,n)}}},9)},!1);var c=new RegExp("(^|\\s)noZensmooth(\\s|$)");window.addEventListener("click",function(t){for(var e=t.target;e&&"A"!==e.tagName;)e=e.parentNode;if(!(!e||1!==t.which||t.shiftKey||t.metaKey||t.ctrlKey||t.altKey)){if(u){var n=history.state&&"object"==typeof history.state?history.state:{};n.zenscrollY=i.getY();try{history.replaceState(n,"")}catch(t){}}var o=e.getAttribute("href")||"";if(0===o.indexOf("#")&&!c.test(e.className)){var a=0,f=document.getElementById(o.substring(1));if("#"!==o){if(!f)return;a=i.getTopOf(f)}t.preventDefault();var s=function(){window.location=o},l=i.setup().edgeOffset;l&&(a=Math.max(0,a-l),r&&(s=function(){history.pushState({},"",o)})),i.toY(a,null,s)}}},!1)}return i});
\ No newline at end of file
diff --git a/stable/site_libs/quarto-nav/quarto-nav.js b/stable/site_libs/quarto-nav/quarto-nav.js
new file mode 100644
index 0000000000..3b21201f95
--- /dev/null
+++ b/stable/site_libs/quarto-nav/quarto-nav.js
@@ -0,0 +1,277 @@
+const headroomChanged = new CustomEvent("quarto-hrChanged", {
+  detail: {},
+  bubbles: true,
+  cancelable: false,
+  composed: false,
+});
+
+window.document.addEventListener("DOMContentLoaded", function () {
+  let init = false;
+
+  // Manage the back to top button, if one is present.
+  let lastScrollTop = window.pageYOffset || document.documentElement.scrollTop;
+  const scrollDownBuffer = 5;
+  const scrollUpBuffer = 35;
+  const btn = document.getElementById("quarto-back-to-top");
+  const hideBackToTop = () => {
+    btn.style.display = "none";
+  };
+  const showBackToTop = () => {
+    btn.style.display = "inline-block";
+  };
+  if (btn) {
+    window.document.addEventListener(
+      "scroll",
+      function () {
+        const currentScrollTop =
+          window.pageYOffset || document.documentElement.scrollTop;
+
+        // Shows and hides the button 'intelligently' as the user scrolls
+        if (currentScrollTop - scrollDownBuffer > lastScrollTop) {
+          hideBackToTop();
+          lastScrollTop = currentScrollTop <= 0 ? 0 : currentScrollTop;
+        } else if (currentScrollTop < lastScrollTop - scrollUpBuffer) {
+          showBackToTop();
+          lastScrollTop = currentScrollTop <= 0 ? 0 : currentScrollTop;
+        }
+
+        // Show the button at the bottom, hides it at the top
+        if (currentScrollTop <= 0) {
+          hideBackToTop();
+        } else if (
+          window.innerHeight + currentScrollTop >=
+          document.body.offsetHeight
+        ) {
+          showBackToTop();
+        }
+      },
+      false
+    );
+  }
+
+  function throttle(func, wait) {
+    var timeout;
+    return function () {
+      const context = this;
+      const args = arguments;
+      const later = function () {
+        clearTimeout(timeout);
+        timeout = null;
+        func.apply(context, args);
+      };
+
+      if (!timeout) {
+        timeout = setTimeout(later, wait);
+      }
+    };
+  }
+
+  function headerOffset() {
+    // Set an offset if there is are fixed top navbar
+    const headerEl = window.document.querySelector("header.fixed-top");
+    if (headerEl) {
+      return headerEl.clientHeight;
+    } else {
+      return 0;
+    }
+  }
+
+  function footerOffset() {
+    const footerEl = window.document.querySelector("footer.footer");
+    if (footerEl) {
+      return footerEl.clientHeight;
+    } else {
+      return 0;
+    }
+  }
+
+  function updateDocumentOffsetWithoutAnimation() {
+    updateDocumentOffset(false);
+  }
+
+  function updateDocumentOffset(animated) {
+    // set body offset
+    const topOffset = headerOffset();
+    const bodyOffset = topOffset + footerOffset();
+    const bodyEl = window.document.body;
+    bodyEl.setAttribute("data-bs-offset", topOffset);
+    bodyEl.style.paddingTop = topOffset + "px";
+
+    // deal with sidebar offsets
+    const sidebars = window.document.querySelectorAll(
+      ".sidebar, .headroom-target"
+    );
+    sidebars.forEach((sidebar) => {
+      if (!animated) {
+        sidebar.classList.add("notransition");
+        // Remove the no transition class after the animation has time to complete
+        setTimeout(function () {
+          sidebar.classList.remove("notransition");
+        }, 201);
+      }
+
+      if (window.Headroom && sidebar.classList.contains("sidebar-unpinned")) {
+        sidebar.style.top = "0";
+        sidebar.style.maxHeight = "100vh";
+      } else {
+        sidebar.style.top = topOffset + "px";
+        sidebar.style.maxHeight = "calc(100vh - " + topOffset + "px)";
+      }
+    });
+
+    // allow space for footer
+    const mainContainer = window.document.querySelector(".quarto-container");
+    if (mainContainer) {
+      mainContainer.style.minHeight = "calc(100vh - " + bodyOffset + "px)";
+    }
+
+    // link offset
+    let linkStyle = window.document.querySelector("#quarto-target-style");
+    if (!linkStyle) {
+      linkStyle = window.document.createElement("style");
+      linkStyle.setAttribute("id", "quarto-target-style");
+      window.document.head.appendChild(linkStyle);
+    }
+    while (linkStyle.firstChild) {
+      linkStyle.removeChild(linkStyle.firstChild);
+    }
+    if (topOffset > 0) {
+      linkStyle.appendChild(
+        window.document.createTextNode(`
+      section:target::before {
+        content: "";
+        display: block;
+        height: ${topOffset}px;
+        margin: -${topOffset}px 0 0;
+      }`)
+      );
+    }
+    if (init) {
+      window.dispatchEvent(headroomChanged);
+    }
+    init = true;
+  }
+
+  // initialize headroom
+  var header = window.document.querySelector("#quarto-header");
+  if (header && window.Headroom) {
+    const headroom = new window.Headroom(header, {
+      tolerance: 5,
+      onPin: function () {
+        const sidebars = window.document.querySelectorAll(
+          ".sidebar, .headroom-target"
+        );
+        sidebars.forEach((sidebar) => {
+          sidebar.classList.remove("sidebar-unpinned");
+        });
+        updateDocumentOffset();
+      },
+      onUnpin: function () {
+        const sidebars = window.document.querySelectorAll(
+          ".sidebar, .headroom-target"
+        );
+        sidebars.forEach((sidebar) => {
+          sidebar.classList.add("sidebar-unpinned");
+        });
+        updateDocumentOffset();
+      },
+    });
+    headroom.init();
+
+    let frozen = false;
+    window.quartoToggleHeadroom = function () {
+      if (frozen) {
+        headroom.unfreeze();
+        frozen = false;
+      } else {
+        headroom.freeze();
+        frozen = true;
+      }
+    };
+  }
+
+  window.addEventListener(
+    "hashchange",
+    function (e) {
+      if (
+        getComputedStyle(document.documentElement).scrollBehavior !== "smooth"
+      ) {
+        window.scrollTo(0, window.pageYOffset - headerOffset());
+      }
+    },
+    false
+  );
+
+  // Observe size changed for the header
+  const headerEl = window.document.querySelector("header.fixed-top");
+  if (headerEl && window.ResizeObserver) {
+    const observer = new window.ResizeObserver(
+      updateDocumentOffsetWithoutAnimation
+    );
+    observer.observe(headerEl, {
+      attributes: true,
+      childList: true,
+      characterData: true,
+    });
+  } else {
+    window.addEventListener(
+      "resize",
+      throttle(updateDocumentOffsetWithoutAnimation, 50)
+    );
+  }
+  setTimeout(updateDocumentOffsetWithoutAnimation, 250);
+
+  // fixup index.html links if we aren't on the filesystem
+  if (window.location.protocol !== "file:") {
+    const links = window.document.querySelectorAll("a");
+    for (let i = 0; i < links.length; i++) {
+      if (links[i].href) {
+        links[i].href = links[i].href.replace(/\/index\.html/, "/");
+      }
+    }
+
+    // Fixup any sharing links that require urls
+    // Append url to any sharing urls
+    const sharingLinks = window.document.querySelectorAll(
+      "a.sidebar-tools-main-item"
+    );
+    for (let i = 0; i < sharingLinks.length; i++) {
+      const sharingLink = sharingLinks[i];
+      const href = sharingLink.getAttribute("href");
+      if (href) {
+        sharingLink.setAttribute(
+          "href",
+          href.replace("|url|", window.location.href)
+        );
+      }
+    }
+
+    // Scroll the active navigation item into view, if necessary
+    const navSidebar = window.document.querySelector("nav#quarto-sidebar");
+    if (navSidebar) {
+      // Find the active item
+      const activeItem = navSidebar.querySelector("li.sidebar-item a.active");
+      if (activeItem) {
+        // Wait for the scroll height and height to resolve by observing size changes on the
+        // nav element that is scrollable
+        const resizeObserver = new ResizeObserver((_entries) => {
+          // The bottom of the element
+          const elBottom = activeItem.offsetTop;
+          const viewBottom = navSidebar.scrollTop + navSidebar.clientHeight;
+
+          // The element height and scroll height are the same, then we are still loading
+          if (viewBottom !== navSidebar.scrollHeight) {
+            // Determine if the item isn't visible and scroll to it
+            if (elBottom >= viewBottom) {
+              navSidebar.scrollTop = elBottom;
+            }
+
+            // stop observing now since we've completed the scroll
+            resizeObserver.unobserve(navSidebar);
+          }
+        });
+        resizeObserver.observe(navSidebar);
+      }
+    }
+  }
+});
diff --git a/stable/site_libs/quarto-search/autocomplete.umd.js b/stable/site_libs/quarto-search/autocomplete.umd.js
new file mode 100644
index 0000000000..619c57cc5c
--- /dev/null
+++ b/stable/site_libs/quarto-search/autocomplete.umd.js
@@ -0,0 +1,3 @@
+/*! @algolia/autocomplete-js 1.7.3 | MIT License | © Algolia, Inc. and contributors | https://github.com/algolia/autocomplete */
+!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?t(exports):"function"==typeof define&&define.amd?define(["exports"],t):t((e="undefined"!=typeof globalThis?globalThis:e||self)["@algolia/autocomplete-js"]={})}(this,(function(e){"use strict";function t(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter((function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable}))),n.push.apply(n,r)}return n}function n(e){for(var n=1;n<arguments.length;n++){var r=null!=arguments[n]?arguments[n]:{};n%2?t(Object(r),!0).forEach((function(t){o(e,t,r[t])})):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(r)):t(Object(r)).forEach((function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(r,t))}))}return e}function r(e){return r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof 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+
diff --git a/stable/site_libs/quarto-search/fuse.min.js b/stable/site_libs/quarto-search/fuse.min.js
new file mode 100644
index 0000000000..adc28356e2
--- /dev/null
+++ b/stable/site_libs/quarto-search/fuse.min.js
@@ -0,0 +1,9 @@
+/**
+ * Fuse.js v6.6.2 - Lightweight fuzzy-search (http://fusejs.io)
+ *
+ * Copyright (c) 2022 Kiro Risk (http://kiro.me)
+ * All Rights Reserved. Apache Software License 2.0
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ */
+var e,t;e=this,t=function(){"use strict";function e(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter((function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable}))),n.push.apply(n,r)}return n}function t(t){for(var n=1;n<arguments.length;n++){var r=null!=arguments[n]?arguments[n]:{};n%2?e(Object(r),!0).forEach((function(e){c(t,e,r[e])})):Object.getOwnPropertyDescriptors?Object.defineProperties(t,Object.getOwnPropertyDescriptors(r)):e(Object(r)).forEach((function(e){Object.defineProperty(t,e,Object.getOwnPropertyDescriptor(r,e))}))}return t}function n(e){return n="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e},n(e)}function r(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}function i(e,t){for(var n=0;n<t.length;n++){var 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c=t.searchIn(n),a=c.isMatch,s=c.score,u=c.indices;a&&r.push({item:n,idx:i,matches:[{score:s,value:n,norm:o,indices:u}]})}})),r}},{key:"_searchLogical",value:function(e){var t=this,n=function(e,t){var n=(arguments.length>2&&void 0!==arguments[2]?arguments[2]:{}).auto,r=void 0===n||n,i=function e(n){var i=Object.keys(n),o=ue(n);if(!o&&i.length>1&&!se(n))return e(le(n));if(he(n)){var c=o?n[ce]:i[0],a=o?n[ae]:n[c];if(!g(a))throw new Error(x(c));var s={keyId:j(c),pattern:a};return r&&(s.searcher=re(a,t)),s}var u={children:[],operator:i[0]};return i.forEach((function(t){var r=n[t];v(r)&&r.forEach((function(t){u.children.push(e(t))}))})),u};return se(e)||(e=le(e)),i(e)}(e,this.options),r=function e(n,r,i){if(!n.children){var o=n.keyId,c=n.searcher,a=t._findMatches({key:t._keyStore.get(o),value:t._myIndex.getValueForItemAtKeyId(r,o),searcher:c});return a&&a.length?[{idx:i,item:r,matches:a}]:[]}for(var s=[],u=0,h=n.children.length;u<h;u+=1){var l=e(n.children[u],r,i);if(l.length)s.push.apply(s,f(l));else if(n.operator===ie)return[]}return s},i=this._myIndex.records,o={},c=[];return i.forEach((function(e){var t=e.$,i=e.i;if(k(t)){var a=r(n,t,i);a.length&&(o[i]||(o[i]={idx:i,item:t,matches:[]},c.push(o[i])),a.forEach((function(e){var t,n=e.matches;(t=o[i].matches).push.apply(t,f(n))})))}})),c}},{key:"_searchObjectList",value:function(e){var t=this,n=re(e,this.options),r=this._myIndex,i=r.keys,o=r.records,c=[];return o.forEach((function(e){var r=e.$,o=e.i;if(k(r)){var a=[];i.forEach((function(e,i){a.push.apply(a,f(t._findMatches({key:e,value:r[i],searcher:n})))})),a.length&&c.push({idx:o,item:r,matches:a})}})),c}},{key:"_findMatches",value:function(e){var t=e.key,n=e.value,r=e.searcher;if(!k(n))return[];var i=[];if(v(n))n.forEach((function(e){var n=e.v,o=e.i,c=e.n;if(k(n)){var a=r.searchIn(n),s=a.isMatch,u=a.score,h=a.indices;s&&i.push({score:u,key:t,value:n,idx:o,norm:c,indices:h})}}));else{var o=n.v,c=n.n,a=r.searchIn(o),s=a.isMatch,u=a.score,h=a.indices;s&&i.push({score:u,key:t,value:o,norm:c,indices:h})}return i}}]),e}();return ye.version="6.6.2",ye.createIndex=F,ye.parseIndex=function(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=t.getFn,r=void 0===n?I.getFn:n,i=t.fieldNormWeight,o=void 0===i?I.fieldNormWeight:i,c=e.keys,a=e.records,s=new $({getFn:r,fieldNormWeight:o});return s.setKeys(c),s.setIndexRecords(a),s},ye.config=I,function(){ne.push.apply(ne,arguments)}(te),ye},"object"==typeof exports&&"undefined"!=typeof module?module.exports=t():"function"==typeof define&&define.amd?define(t):(e="undefined"!=typeof globalThis?globalThis:e||self).Fuse=t();
\ No newline at end of file
diff --git a/stable/site_libs/quarto-search/quarto-search.js b/stable/site_libs/quarto-search/quarto-search.js
new file mode 100644
index 0000000000..f5d852d137
--- /dev/null
+++ b/stable/site_libs/quarto-search/quarto-search.js
@@ -0,0 +1,1140 @@
+const kQueryArg = "q";
+const kResultsArg = "show-results";
+
+// If items don't provide a URL, then both the navigator and the onSelect
+// function aren't called (and therefore, the default implementation is used)
+//
+// We're using this sentinel URL to signal to those handlers that this
+// item is a more item (along with the type) and can be handled appropriately
+const kItemTypeMoreHref = "0767FDFD-0422-4E5A-BC8A-3BE11E5BBA05";
+
+window.document.addEventListener("DOMContentLoaded", function (_event) {
+  // Ensure that search is available on this page. If it isn't,
+  // should return early and not do anything
+  var searchEl = window.document.getElementById("quarto-search");
+  if (!searchEl) return;
+
+  const { autocomplete } = window["@algolia/autocomplete-js"];
+
+  let quartoSearchOptions = {};
+  let language = {};
+  const searchOptionEl = window.document.getElementById(
+    "quarto-search-options"
+  );
+  if (searchOptionEl) {
+    const jsonStr = searchOptionEl.textContent;
+    quartoSearchOptions = JSON.parse(jsonStr);
+    language = quartoSearchOptions.language;
+  }
+
+  // note the search mode
+  if (quartoSearchOptions.type === "overlay") {
+    searchEl.classList.add("type-overlay");
+  } else {
+    searchEl.classList.add("type-textbox");
+  }
+
+  // Used to determine highlighting behavior for this page
+  // A `q` query param is expected when the user follows a search
+  // to this page
+  const currentUrl = new URL(window.location);
+  const query = currentUrl.searchParams.get(kQueryArg);
+  const showSearchResults = currentUrl.searchParams.get(kResultsArg);
+  const mainEl = window.document.querySelector("main");
+
+  // highlight matches on the page
+  if (query !== null && mainEl) {
+    // perform any highlighting
+    highlight(escapeRegExp(query), mainEl);
+
+    // fix up the URL to remove the q query param
+    const replacementUrl = new URL(window.location);
+    replacementUrl.searchParams.delete(kQueryArg);
+    window.history.replaceState({}, "", replacementUrl);
+  }
+
+  // function to clear highlighting on the page when the search query changes
+  // (e.g. if the user edits the query or clears it)
+  let highlighting = true;
+  const resetHighlighting = (searchTerm) => {
+    if (mainEl && highlighting && query !== null && searchTerm !== query) {
+      clearHighlight(query, mainEl);
+      highlighting = false;
+    }
+  };
+
+  // Clear search highlighting when the user scrolls sufficiently
+  const resetFn = () => {
+    resetHighlighting("");
+    window.removeEventListener("quarto-hrChanged", resetFn);
+    window.removeEventListener("quarto-sectionChanged", resetFn);
+  };
+
+  // Register this event after the initial scrolling and settling of events
+  // on the page
+  window.addEventListener("quarto-hrChanged", resetFn);
+  window.addEventListener("quarto-sectionChanged", resetFn);
+
+  // Responsively switch to overlay mode if the search is present on the navbar
+  // Note that switching the sidebar to overlay mode requires more coordinate (not just
+  // the media query since we generate different HTML for sidebar overlays than we do
+  // for sidebar input UI)
+  const detachedMediaQuery =
+    quartoSearchOptions.type === "overlay" ? "all" : "(max-width: 991px)";
+
+  // If configured, include the analytics client to send insights
+  const plugins = configurePlugins(quartoSearchOptions);
+
+  let lastState = null;
+  const { setIsOpen, setQuery, setCollections } = autocomplete({
+    container: searchEl,
+    detachedMediaQuery: detachedMediaQuery,
+    defaultActiveItemId: 0,
+    panelContainer: "#quarto-search-results",
+    panelPlacement: quartoSearchOptions["panel-placement"],
+    debug: false,
+    openOnFocus: true,
+    plugins,
+    classNames: {
+      form: "d-flex",
+    },
+    translations: {
+      clearButtonTitle: language["search-clear-button-title"],
+      detachedCancelButtonText: language["search-detached-cancel-button-title"],
+      submitButtonTitle: language["search-submit-button-title"],
+    },
+    initialState: {
+      query,
+    },
+    getItemUrl({ item }) {
+      return item.href;
+    },
+    onStateChange({ state }) {
+      // Perhaps reset highlighting
+      resetHighlighting(state.query);
+
+      // If the panel just opened, ensure the panel is positioned properly
+      if (state.isOpen) {
+        if (lastState && !lastState.isOpen) {
+          setTimeout(() => {
+            positionPanel(quartoSearchOptions["panel-placement"]);
+          }, 150);
+        }
+      }
+
+      // Perhaps show the copy link
+      showCopyLink(state.query, quartoSearchOptions);
+
+      lastState = state;
+    },
+    reshape({ sources, state }) {
+      return sources.map((source) => {
+        try {
+          const items = source.getItems();
+
+          // Validate the items
+          validateItems(items);
+
+          // group the items by document
+          const groupedItems = new Map();
+          items.forEach((item) => {
+            const hrefParts = item.href.split("#");
+            const baseHref = hrefParts[0];
+            const isDocumentItem = hrefParts.length === 1;
+
+            const items = groupedItems.get(baseHref);
+            if (!items) {
+              groupedItems.set(baseHref, [item]);
+            } else {
+              // If the href for this item matches the document
+              // exactly, place this item first as it is the item that represents
+              // the document itself
+              if (isDocumentItem) {
+                items.unshift(item);
+              } else {
+                items.push(item);
+              }
+              groupedItems.set(baseHref, items);
+            }
+          });
+
+          const reshapedItems = [];
+          let count = 1;
+          for (const [_key, value] of groupedItems) {
+            const firstItem = value[0];
+            reshapedItems.push({
+              ...firstItem,
+              type: kItemTypeDoc,
+            });
+
+            const collapseMatches = quartoSearchOptions["collapse-after"];
+            const collapseCount =
+              typeof collapseMatches === "number" ? collapseMatches : 1;
+
+            if (value.length > 1) {
+              const target = `search-more-${count}`;
+              const isExpanded =
+                state.context.expanded &&
+                state.context.expanded.includes(target);
+
+              const remainingCount = value.length - collapseCount;
+
+              for (let i = 1; i < value.length; i++) {
+                if (collapseMatches && i === collapseCount) {
+                  reshapedItems.push({
+                    target,
+                    title: isExpanded
+                      ? language["search-hide-matches-text"]
+                      : remainingCount === 1
+                      ? `${remainingCount} ${language["search-more-match-text"]}`
+                      : `${remainingCount} ${language["search-more-matches-text"]}`,
+                    type: kItemTypeMore,
+                    href: kItemTypeMoreHref,
+                  });
+                }
+
+                if (isExpanded || !collapseMatches || i < collapseCount) {
+                  reshapedItems.push({
+                    ...value[i],
+                    type: kItemTypeItem,
+                    target,
+                  });
+                }
+              }
+            }
+            count += 1;
+          }
+
+          return {
+            ...source,
+            getItems() {
+              return reshapedItems;
+            },
+          };
+        } catch (error) {
+          // Some form of error occurred
+          return {
+            ...source,
+            getItems() {
+              return [
+                {
+                  title: error.name || "An Error Occurred While Searching",
+                  text:
+                    error.message ||
+                    "An unknown error occurred while attempting to perform the requested search.",
+                  type: kItemTypeError,
+                },
+              ];
+            },
+          };
+        }
+      });
+    },
+    navigator: {
+      navigate({ itemUrl }) {
+        if (itemUrl !== offsetURL(kItemTypeMoreHref)) {
+          window.location.assign(itemUrl);
+        }
+      },
+      navigateNewTab({ itemUrl }) {
+        if (itemUrl !== offsetURL(kItemTypeMoreHref)) {
+          const windowReference = window.open(itemUrl, "_blank", "noopener");
+          if (windowReference) {
+            windowReference.focus();
+          }
+        }
+      },
+      navigateNewWindow({ itemUrl }) {
+        if (itemUrl !== offsetURL(kItemTypeMoreHref)) {
+          window.open(itemUrl, "_blank", "noopener");
+        }
+      },
+    },
+    getSources({ state, setContext, setActiveItemId, refresh }) {
+      return [
+        {
+          sourceId: "documents",
+          getItemUrl({ item }) {
+            if (item.href) {
+              return offsetURL(item.href);
+            } else {
+              return undefined;
+            }
+          },
+          onSelect({
+            item,
+            state,
+            setContext,
+            setIsOpen,
+            setActiveItemId,
+            refresh,
+          }) {
+            if (item.type === kItemTypeMore) {
+              toggleExpanded(item, state, setContext, setActiveItemId, refresh);
+
+              // Toggle more
+              setIsOpen(true);
+            }
+          },
+          getItems({ query }) {
+            if (query === null || query === "") {
+              return [];
+            }
+
+            const limit = quartoSearchOptions.limit;
+            if (quartoSearchOptions.algolia) {
+              return algoliaSearch(query, limit, quartoSearchOptions.algolia);
+            } else {
+              // Fuse search options
+              const fuseSearchOptions = {
+                isCaseSensitive: false,
+                shouldSort: true,
+                minMatchCharLength: 2,
+                limit: limit,
+              };
+
+              return readSearchData().then(function (fuse) {
+                return fuseSearch(query, fuse, fuseSearchOptions);
+              });
+            }
+          },
+          templates: {
+            noResults({ createElement }) {
+              const hasQuery = lastState.query;
+
+              return createElement(
+                "div",
+                {
+                  class: `quarto-search-no-results${
+                    hasQuery ? "" : " no-query"
+                  }`,
+                },
+                language["search-no-results-text"]
+              );
+            },
+            header({ items, createElement }) {
+              // count the documents
+              const count = items.filter((item) => {
+                return item.type === kItemTypeDoc;
+              }).length;
+
+              if (count > 0) {
+                return createElement(
+                  "div",
+                  { class: "search-result-header" },
+                  `${count} ${language["search-matching-documents-text"]}`
+                );
+              } else {
+                return createElement(
+                  "div",
+                  { class: "search-result-header-no-results" },
+                  ``
+                );
+              }
+            },
+            footer({ _items, createElement }) {
+              if (
+                quartoSearchOptions.algolia &&
+                quartoSearchOptions.algolia["show-logo"]
+              ) {
+                const libDir = quartoSearchOptions.algolia["libDir"];
+                const logo = createElement("img", {
+                  src: offsetURL(
+                    `${libDir}/quarto-search/search-by-algolia.svg`
+                  ),
+                  class: "algolia-search-logo",
+                });
+                return createElement(
+                  "a",
+                  { href: "http://www.algolia.com/" },
+                  logo
+                );
+              }
+            },
+
+            item({ item, createElement }) {
+              return renderItem(
+                item,
+                createElement,
+                state,
+                setActiveItemId,
+                setContext,
+                refresh
+              );
+            },
+          },
+        },
+      ];
+    },
+  });
+
+  window.quartoOpenSearch = () => {
+    setIsOpen(false);
+    setIsOpen(true);
+    focusSearchInput();
+  };
+
+  // Remove the labeleledby attribute since it is pointing
+  // to a non-existent label
+  if (quartoSearchOptions.type === "overlay") {
+    const inputEl = window.document.querySelector(
+      "#quarto-search .aa-Autocomplete"
+    );
+    if (inputEl) {
+      inputEl.removeAttribute("aria-labelledby");
+    }
+  }
+
+  // If the main document scrolls dismiss the search results
+  // (otherwise, since they're floating in the document they can scroll with the document)
+  window.document.body.onscroll = () => {
+    setIsOpen(false);
+  };
+
+  if (showSearchResults) {
+    setIsOpen(true);
+    focusSearchInput();
+  }
+});
+
+function configurePlugins(quartoSearchOptions) {
+  const autocompletePlugins = [];
+  const algoliaOptions = quartoSearchOptions.algolia;
+  if (
+    algoliaOptions &&
+    algoliaOptions["analytics-events"] &&
+    algoliaOptions["search-only-api-key"] &&
+    algoliaOptions["application-id"]
+  ) {
+    const apiKey = algoliaOptions["search-only-api-key"];
+    const appId = algoliaOptions["application-id"];
+
+    // Aloglia insights may not be loaded because they require cookie consent
+    // Use deferred loading so events will start being recorded when/if consent
+    // is granted.
+    const algoliaInsightsDeferredPlugin = deferredLoadPlugin(() => {
+      if (
+        window.aa &&
+        window["@algolia/autocomplete-plugin-algolia-insights"]
+      ) {
+        window.aa("init", {
+          appId,
+          apiKey,
+          useCookie: true,
+        });
+
+        const { createAlgoliaInsightsPlugin } =
+          window["@algolia/autocomplete-plugin-algolia-insights"];
+        // Register the insights client
+        const algoliaInsightsPlugin = createAlgoliaInsightsPlugin({
+          insightsClient: window.aa,
+          onItemsChange({ insights, insightsEvents }) {
+            const events = insightsEvents.map((event) => {
+              const maxEvents = event.objectIDs.slice(0, 20);
+              return {
+                ...event,
+                objectIDs: maxEvents,
+              };
+            });
+
+            insights.viewedObjectIDs(...events);
+          },
+        });
+        return algoliaInsightsPlugin;
+      }
+    });
+
+    // Add the plugin
+    autocompletePlugins.push(algoliaInsightsDeferredPlugin);
+    return autocompletePlugins;
+  }
+}
+
+// For plugins that may not load immediately, create a wrapper
+// plugin and forward events and plugin data once the plugin
+// is initialized. This is useful for cases like cookie consent
+// which may prevent the analytics insights event plugin from initializing
+// immediately.
+function deferredLoadPlugin(createPlugin) {
+  let plugin = undefined;
+  let subscribeObj = undefined;
+  const wrappedPlugin = () => {
+    if (!plugin && subscribeObj) {
+      plugin = createPlugin();
+      if (plugin && plugin.subscribe) {
+        plugin.subscribe(subscribeObj);
+      }
+    }
+    return plugin;
+  };
+
+  return {
+    subscribe: (obj) => {
+      subscribeObj = obj;
+    },
+    onStateChange: (obj) => {
+      const plugin = wrappedPlugin();
+      if (plugin && plugin.onStateChange) {
+        plugin.onStateChange(obj);
+      }
+    },
+    onSubmit: (obj) => {
+      const plugin = wrappedPlugin();
+      if (plugin && plugin.onSubmit) {
+        plugin.onSubmit(obj);
+      }
+    },
+    onReset: (obj) => {
+      const plugin = wrappedPlugin();
+      if (plugin && plugin.onReset) {
+        plugin.onReset(obj);
+      }
+    },
+    getSources: (obj) => {
+      const plugin = wrappedPlugin();
+      if (plugin && plugin.getSources) {
+        return plugin.getSources(obj);
+      } else {
+        return Promise.resolve([]);
+      }
+    },
+    data: (obj) => {
+      const plugin = wrappedPlugin();
+      if (plugin && plugin.data) {
+        plugin.data(obj);
+      }
+    },
+  };
+}
+
+function validateItems(items) {
+  // Validate the first item
+  if (items.length > 0) {
+    const item = items[0];
+    const missingFields = [];
+    if (item.href == undefined) {
+      missingFields.push("href");
+    }
+    if (!item.title == undefined) {
+      missingFields.push("title");
+    }
+    if (!item.text == undefined) {
+      missingFields.push("text");
+    }
+
+    if (missingFields.length === 1) {
+      throw {
+        name: `Error: Search index is missing the <code>${missingFields[0]}</code> field.`,
+        message: `The items being returned for this search do not include all the required fields. Please ensure that your index items include the <code>${missingFields[0]}</code> field or use <code>index-fields</code> in your <code>_quarto.yml</code> file to specify the field names.`,
+      };
+    } else if (missingFields.length > 1) {
+      const missingFieldList = missingFields
+        .map((field) => {
+          return `<code>${field}</code>`;
+        })
+        .join(", ");
+
+      throw {
+        name: `Error: Search index is missing the following fields: ${missingFieldList}.`,
+        message: `The items being returned for this search do not include all the required fields. Please ensure that your index items includes the following fields: ${missingFieldList}, or use <code>index-fields</code> in your <code>_quarto.yml</code> file to specify the field names.`,
+      };
+    }
+  }
+}
+
+let lastQuery = null;
+function showCopyLink(query, options) {
+  const language = options.language;
+  lastQuery = query;
+  // Insert share icon
+  const inputSuffixEl = window.document.body.querySelector(
+    ".aa-Form .aa-InputWrapperSuffix"
+  );
+
+  if (inputSuffixEl) {
+    let copyButtonEl = window.document.body.querySelector(
+      ".aa-Form .aa-InputWrapperSuffix .aa-CopyButton"
+    );
+
+    if (copyButtonEl === null) {
+      copyButtonEl = window.document.createElement("button");
+      copyButtonEl.setAttribute("class", "aa-CopyButton");
+      copyButtonEl.setAttribute("type", "button");
+      copyButtonEl.setAttribute("title", language["search-copy-link-title"]);
+      copyButtonEl.onmousedown = (e) => {
+        e.preventDefault();
+        e.stopPropagation();
+      };
+
+      const linkIcon = "bi-clipboard";
+      const checkIcon = "bi-check2";
+
+      const shareIconEl = window.document.createElement("i");
+      shareIconEl.setAttribute("class", `bi ${linkIcon}`);
+      copyButtonEl.appendChild(shareIconEl);
+      inputSuffixEl.prepend(copyButtonEl);
+
+      const clipboard = new window.ClipboardJS(".aa-CopyButton", {
+        text: function (_trigger) {
+          const copyUrl = new URL(window.location);
+          copyUrl.searchParams.set(kQueryArg, lastQuery);
+          copyUrl.searchParams.set(kResultsArg, "1");
+          return copyUrl.toString();
+        },
+      });
+      clipboard.on("success", function (e) {
+        // Focus the input
+
+        // button target
+        const button = e.trigger;
+        const icon = button.querySelector("i.bi");
+
+        // flash "checked"
+        icon.classList.add(checkIcon);
+        icon.classList.remove(linkIcon);
+        setTimeout(function () {
+          icon.classList.remove(checkIcon);
+          icon.classList.add(linkIcon);
+        }, 1000);
+      });
+    }
+
+    // If there is a query, show the link icon
+    if (copyButtonEl) {
+      if (lastQuery && options["copy-button"]) {
+        copyButtonEl.style.display = "flex";
+      } else {
+        copyButtonEl.style.display = "none";
+      }
+    }
+  }
+}
+
+/* Search Index Handling */
+// create the index
+var fuseIndex = undefined;
+async function readSearchData() {
+  // Initialize the search index on demand
+  if (fuseIndex === undefined) {
+    // create fuse index
+    const options = {
+      keys: [
+        { name: "title", weight: 20 },
+        { name: "section", weight: 20 },
+        { name: "text", weight: 10 },
+      ],
+      ignoreLocation: true,
+      threshold: 0.1,
+    };
+    const fuse = new window.Fuse([], options);
+
+    // fetch the main search.json
+    const response = await fetch(offsetURL("search.json"));
+    if (response.status == 200) {
+      return response.json().then(function (searchDocs) {
+        searchDocs.forEach(function (searchDoc) {
+          fuse.add(searchDoc);
+        });
+        fuseIndex = fuse;
+        return fuseIndex;
+      });
+    } else {
+      return Promise.reject(
+        new Error(
+          "Unexpected status from search index request: " + response.status
+        )
+      );
+    }
+  }
+  return fuseIndex;
+}
+
+function inputElement() {
+  return window.document.body.querySelector(".aa-Form .aa-Input");
+}
+
+function focusSearchInput() {
+  setTimeout(() => {
+    const inputEl = inputElement();
+    if (inputEl) {
+      inputEl.focus();
+    }
+  }, 50);
+}
+
+/* Panels */
+const kItemTypeDoc = "document";
+const kItemTypeMore = "document-more";
+const kItemTypeItem = "document-item";
+const kItemTypeError = "error";
+
+function renderItem(
+  item,
+  createElement,
+  state,
+  setActiveItemId,
+  setContext,
+  refresh
+) {
+  switch (item.type) {
+    case kItemTypeDoc:
+      return createDocumentCard(
+        createElement,
+        "file-richtext",
+        item.title,
+        item.section,
+        item.text,
+        item.href
+      );
+    case kItemTypeMore:
+      return createMoreCard(
+        createElement,
+        item,
+        state,
+        setActiveItemId,
+        setContext,
+        refresh
+      );
+    case kItemTypeItem:
+      return createSectionCard(
+        createElement,
+        item.section,
+        item.text,
+        item.href
+      );
+    case kItemTypeError:
+      return createErrorCard(createElement, item.title, item.text);
+    default:
+      return undefined;
+  }
+}
+
+function createDocumentCard(createElement, icon, title, section, text, href) {
+  const iconEl = createElement("i", {
+    class: `bi bi-${icon} search-result-icon`,
+  });
+  const titleEl = createElement("p", { class: "search-result-title" }, title);
+  const titleContainerEl = createElement(
+    "div",
+    { class: "search-result-title-container" },
+    [iconEl, titleEl]
+  );
+
+  const textEls = [];
+  if (section) {
+    const sectionEl = createElement(
+      "p",
+      { class: "search-result-section" },
+      section
+    );
+    textEls.push(sectionEl);
+  }
+  const descEl = createElement("p", {
+    class: "search-result-text",
+    dangerouslySetInnerHTML: {
+      __html: text,
+    },
+  });
+  textEls.push(descEl);
+
+  const textContainerEl = createElement(
+    "div",
+    { class: "search-result-text-container" },
+    textEls
+  );
+
+  const containerEl = createElement(
+    "div",
+    {
+      class: "search-result-container",
+    },
+    [titleContainerEl, textContainerEl]
+  );
+
+  const linkEl = createElement(
+    "a",
+    {
+      href: offsetURL(href),
+      class: "search-result-link",
+    },
+    containerEl
+  );
+
+  const classes = ["search-result-doc", "search-item"];
+  if (!section) {
+    classes.push("document-selectable");
+  }
+
+  return createElement(
+    "div",
+    {
+      class: classes.join(" "),
+    },
+    linkEl
+  );
+}
+
+function createMoreCard(
+  createElement,
+  item,
+  state,
+  setActiveItemId,
+  setContext,
+  refresh
+) {
+  const moreCardEl = createElement(
+    "div",
+    {
+      class: "search-result-more search-item",
+      onClick: (e) => {
+        // Handle expanding the sections by adding the expanded
+        // section to the list of expanded sections
+        toggleExpanded(item, state, setContext, setActiveItemId, refresh);
+        e.stopPropagation();
+      },
+    },
+    item.title
+  );
+
+  return moreCardEl;
+}
+
+function toggleExpanded(item, state, setContext, setActiveItemId, refresh) {
+  const expanded = state.context.expanded || [];
+  if (expanded.includes(item.target)) {
+    setContext({
+      expanded: expanded.filter((target) => target !== item.target),
+    });
+  } else {
+    setContext({ expanded: [...expanded, item.target] });
+  }
+
+  refresh();
+  setActiveItemId(item.__autocomplete_id);
+}
+
+function createSectionCard(createElement, section, text, href) {
+  const sectionEl = createSection(createElement, section, text, href);
+  return createElement(
+    "div",
+    {
+      class: "search-result-doc-section search-item",
+    },
+    sectionEl
+  );
+}
+
+function createSection(createElement, title, text, href) {
+  const descEl = createElement("p", {
+    class: "search-result-text",
+    dangerouslySetInnerHTML: {
+      __html: text,
+    },
+  });
+
+  const titleEl = createElement("p", { class: "search-result-section" }, title);
+  const linkEl = createElement(
+    "a",
+    {
+      href: offsetURL(href),
+      class: "search-result-link",
+    },
+    [titleEl, descEl]
+  );
+  return linkEl;
+}
+
+function createErrorCard(createElement, title, text) {
+  const descEl = createElement("p", {
+    class: "search-error-text",
+    dangerouslySetInnerHTML: {
+      __html: text,
+    },
+  });
+
+  const titleEl = createElement("p", {
+    class: "search-error-title",
+    dangerouslySetInnerHTML: {
+      __html: `<i class="bi bi-exclamation-circle search-error-icon"></i> ${title}`,
+    },
+  });
+  const errorEl = createElement("div", { class: "search-error" }, [
+    titleEl,
+    descEl,
+  ]);
+  return errorEl;
+}
+
+function positionPanel(pos) {
+  const panelEl = window.document.querySelector(
+    "#quarto-search-results .aa-Panel"
+  );
+  const inputEl = window.document.querySelector(
+    "#quarto-search .aa-Autocomplete"
+  );
+
+  if (panelEl && inputEl) {
+    panelEl.style.top = `${Math.round(panelEl.offsetTop)}px`;
+    if (pos === "start") {
+      panelEl.style.left = `${Math.round(inputEl.left)}px`;
+    } else {
+      panelEl.style.right = `${Math.round(inputEl.offsetRight)}px`;
+    }
+  }
+}
+
+/* Highlighting */
+// highlighting functions
+function highlightMatch(query, text) {
+  if (text) {
+    const start = text.toLowerCase().indexOf(query.toLowerCase());
+    if (start !== -1) {
+      const startMark = "<mark class='search-match'>";
+      const endMark = "</mark>";
+
+      const end = start + query.length;
+      text =
+        text.slice(0, start) +
+        startMark +
+        text.slice(start, end) +
+        endMark +
+        text.slice(end);
+      const startInfo = clipStart(text, start);
+      const endInfo = clipEnd(
+        text,
+        startInfo.position + startMark.length + endMark.length
+      );
+      text =
+        startInfo.prefix +
+        text.slice(startInfo.position, endInfo.position) +
+        endInfo.suffix;
+
+      return text;
+    } else {
+      return text;
+    }
+  } else {
+    return text;
+  }
+}
+
+function clipStart(text, pos) {
+  const clipStart = pos - 50;
+  if (clipStart < 0) {
+    // This will just return the start of the string
+    return {
+      position: 0,
+      prefix: "",
+    };
+  } else {
+    // We're clipping before the start of the string, walk backwards to the first space.
+    const spacePos = findSpace(text, pos, -1);
+    return {
+      position: spacePos.position,
+      prefix: "",
+    };
+  }
+}
+
+function clipEnd(text, pos) {
+  const clipEnd = pos + 200;
+  if (clipEnd > text.length) {
+    return {
+      position: text.length,
+      suffix: "",
+    };
+  } else {
+    const spacePos = findSpace(text, clipEnd, 1);
+    return {
+      position: spacePos.position,
+      suffix: spacePos.clipped ? "…" : "",
+    };
+  }
+}
+
+function findSpace(text, start, step) {
+  let stepPos = start;
+  while (stepPos > -1 && stepPos < text.length) {
+    const char = text[stepPos];
+    if (char === " " || char === "," || char === ":") {
+      return {
+        position: step === 1 ? stepPos : stepPos - step,
+        clipped: stepPos > 1 && stepPos < text.length,
+      };
+    }
+    stepPos = stepPos + step;
+  }
+
+  return {
+    position: stepPos - step,
+    clipped: false,
+  };
+}
+
+// removes highlighting as implemented by the mark tag
+function clearHighlight(searchterm, el) {
+  const childNodes = el.childNodes;
+  for (let i = childNodes.length - 1; i >= 0; i--) {
+    const node = childNodes[i];
+    if (node.nodeType === Node.ELEMENT_NODE) {
+      if (
+        node.tagName === "MARK" &&
+        node.innerText.toLowerCase() === searchterm.toLowerCase()
+      ) {
+        el.replaceChild(document.createTextNode(node.innerText), node);
+      } else {
+        clearHighlight(searchterm, node);
+      }
+    }
+  }
+}
+
+function escapeRegExp(string) {
+  return string.replace(/[.*+?^${}()|[\]\\]/g, "\\$&"); // $& means the whole matched string
+}
+
+// highlight matches
+function highlight(term, el) {
+  const termRegex = new RegExp(term, "ig");
+  const childNodes = el.childNodes;
+
+  // walk back to front avoid mutating elements in front of us
+  for (let i = childNodes.length - 1; i >= 0; i--) {
+    const node = childNodes[i];
+
+    if (node.nodeType === Node.TEXT_NODE) {
+      // Search text nodes for text to highlight
+      const text = node.nodeValue;
+
+      let startIndex = 0;
+      let matchIndex = text.search(termRegex);
+      if (matchIndex > -1) {
+        const markFragment = document.createDocumentFragment();
+        while (matchIndex > -1) {
+          const prefix = text.slice(startIndex, matchIndex);
+          markFragment.appendChild(document.createTextNode(prefix));
+
+          const mark = document.createElement("mark");
+          mark.appendChild(
+            document.createTextNode(
+              text.slice(matchIndex, matchIndex + term.length)
+            )
+          );
+          markFragment.appendChild(mark);
+
+          startIndex = matchIndex + term.length;
+          matchIndex = text.slice(startIndex).search(new RegExp(term, "ig"));
+          if (matchIndex > -1) {
+            matchIndex = startIndex + matchIndex;
+          }
+        }
+        if (startIndex < text.length) {
+          markFragment.appendChild(
+            document.createTextNode(text.slice(startIndex, text.length))
+          );
+        }
+
+        el.replaceChild(markFragment, node);
+      }
+    } else if (node.nodeType === Node.ELEMENT_NODE) {
+      // recurse through elements
+      highlight(term, node);
+    }
+  }
+}
+
+/* Link Handling */
+// get the offset from this page for a given site root relative url
+function offsetURL(url) {
+  var offset = getMeta("quarto:offset");
+  return offset ? offset + url : url;
+}
+
+// read a meta tag value
+function getMeta(metaName) {
+  var metas = window.document.getElementsByTagName("meta");
+  for (let i = 0; i < metas.length; i++) {
+    if (metas[i].getAttribute("name") === metaName) {
+      return metas[i].getAttribute("content");
+    }
+  }
+  return "";
+}
+
+function algoliaSearch(query, limit, algoliaOptions) {
+  const { getAlgoliaResults } = window["@algolia/autocomplete-preset-algolia"];
+
+  const applicationId = algoliaOptions["application-id"];
+  const searchOnlyApiKey = algoliaOptions["search-only-api-key"];
+  const indexName = algoliaOptions["index-name"];
+  const indexFields = algoliaOptions["index-fields"];
+  const searchClient = window.algoliasearch(applicationId, searchOnlyApiKey);
+  const searchParams = algoliaOptions["params"];
+  const searchAnalytics = !!algoliaOptions["analytics-events"];
+
+  return getAlgoliaResults({
+    searchClient,
+    queries: [
+      {
+        indexName: indexName,
+        query,
+        params: {
+          hitsPerPage: limit,
+          clickAnalytics: searchAnalytics,
+          ...searchParams,
+        },
+      },
+    ],
+    transformResponse: (response) => {
+      if (!indexFields) {
+        return response.hits.map((hit) => {
+          return hit.map((item) => {
+            return {
+              ...item,
+              text: highlightMatch(query, item.text),
+            };
+          });
+        });
+      } else {
+        const remappedHits = response.hits.map((hit) => {
+          return hit.map((item) => {
+            const newItem = { ...item };
+            ["href", "section", "title", "text"].forEach((keyName) => {
+              const mappedName = indexFields[keyName];
+              if (
+                mappedName &&
+                item[mappedName] !== undefined &&
+                mappedName !== keyName
+              ) {
+                newItem[keyName] = item[mappedName];
+                delete newItem[mappedName];
+              }
+            });
+            newItem.text = highlightMatch(query, newItem.text);
+            return newItem;
+          });
+        });
+        return remappedHits;
+      }
+    },
+  });
+}
+
+function fuseSearch(query, fuse, fuseOptions) {
+  return fuse.search(query, fuseOptions).map((result) => {
+    const addParam = (url, name, value) => {
+      const anchorParts = url.split("#");
+      const baseUrl = anchorParts[0];
+      const sep = baseUrl.search("\\?") > 0 ? "&" : "?";
+      anchorParts[0] = baseUrl + sep + name + "=" + value;
+      return anchorParts.join("#");
+    };
+
+    return {
+      title: result.item.title,
+      section: result.item.section,
+      href: addParam(result.item.href, kQueryArg, query),
+      text: highlightMatch(query, result.item.text),
+    };
+  });
+}
diff --git a/stable/sitemap.xml b/stable/sitemap.xml
new file mode 100644
index 0000000000..fd7232da0f
--- /dev/null
+++ b/stable/sitemap.xml
@@ -0,0 +1,571 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9">
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/test-utils/envir_hook.html</loc>
+    <lastmod>2023-09-25T11:38:47.373Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/exposure/ext01.html</loc>
+    <lastmod>2023-09-25T11:38:42.541Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/risk-management-plan/rmpt03.html</loc>
+    <lastmod>2023-09-25T11:37:21.640Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/risk-management-plan/rmpt04.html</loc>
+    <lastmod>2023-09-25T11:36:25.000Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/risk-management-plan/rmpt06.html</loc>
+    <lastmod>2023-09-25T11:35:29.704Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/disposition/pdt01.html</loc>
+    <lastmod>2023-09-25T11:35:08.280Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/demography/dmt01.html</loc>
+    <lastmod>2023-09-25T11:33:59.867Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt05.html</loc>
+    <lastmod>2023-09-25T11:32:51.519Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt09.html</loc>
+    <lastmod>2023-09-25T11:32:29.559Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt06.html</loc>
+    <lastmod>2023-09-25T11:31:39.670Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt10.html</loc>
+    <lastmod>2023-09-25T11:30:44.150Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt03.html</loc>
+    <lastmod>2023-09-25T11:30:24.262Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt07.html</loc>
+    <lastmod>2023-09-25T11:29:17.534Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt12.html</loc>
+    <lastmod>2023-09-25T11:28:06.301Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt13.html</loc>
+    <lastmod>2023-09-25T11:27:15.205Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/lab-results/lbt10_bl.html</loc>
+    <lastmod>2023-09-25T11:25:15.852Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/ADA/adat03.html</loc>
+    <lastmod>2023-09-25T11:24:56.660Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/ADA/adat01.html</loc>
+    <lastmod>2023-09-25T11:24:36.152Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/deaths/dtht01.html</loc>
+    <lastmod>2023-09-25T11:24:14.052Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet04_pi.html</loc>
+    <lastmod>2023-09-25T11:23:27.712Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet02.html</loc>
+    <lastmod>2023-09-25T11:22:08.447Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet06_smq.html</loc>
+    <lastmod>2023-09-25T11:20:28.503Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet05.html</loc>
+    <lastmod>2023-09-25T11:19:08.894Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet05_all.html</loc>
+    <lastmod>2023-09-25T11:18:02.266Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet09.html</loc>
+    <lastmod>2023-09-25T11:17:02.161Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet10.html</loc>
+    <lastmod>2023-09-25T11:15:59.269Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/medical-history/mht01.html</loc>
+    <lastmod>2023-09-25T11:14:40.357Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/ECG/egt02.html</loc>
+    <lastmod>2023-09-25T11:14:00.372Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/ECG/egt05_qtcat.html</loc>
+    <lastmod>2023-09-25T11:12:45.392Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/pharmacokinetic/pkpt02.html</loc>
+    <lastmod>2023-09-25T11:11:23.283Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/pharmacokinetic/pkpt03.html</loc>
+    <lastmod>2023-09-25T11:11:04.087Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/pharmacokinetic/pkpt06.html</loc>
+    <lastmod>2023-09-25T11:10:56.107Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/pharmacokinetic/pkpt05.html</loc>
+    <lastmod>2023-09-25T11:10:36.943Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/pharmacokinetic/pkpt11.html</loc>
+    <lastmod>2023-09-25T11:10:15.647Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/concomitant-medications/cmt01b.html</loc>
+    <lastmod>2023-09-25T11:09:31.443Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/concomitant-medications/cmt01.html</loc>
+    <lastmod>2023-09-25T11:08:13.782Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/vital-signs/vst01.html</loc>
+    <lastmod>2023-09-25T11:07:12.714Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/disclosures/eudrat02.html</loc>
+    <lastmod>2023-09-25T11:06:03.250Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/aovt03.html</loc>
+    <lastmod>2023-09-25T11:05:43.402Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/rbmit01.html</loc>
+    <lastmod>2023-09-25T11:04:26.481Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/cmht01.html</loc>
+    <lastmod>2023-09-25T11:03:07.277Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/cfbt01.html</loc>
+    <lastmod>2023-09-25T11:01:28.408Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/lgrt02.html</loc>
+    <lastmod>2023-09-25T11:00:09.336Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/ttet01.html</loc>
+    <lastmod>2023-09-25T10:58:44.027Z</lastmod>
+  </url>
+  <url>
+    <loc>https://insightsengineering.github.io/tlg-catalog/tables/efficacy/rspt01.html</loc>
+    <lastmod>2023-09-25T10:56:56.347Z</lastmod>
+  </url>
+  <url>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Baseline Prevalence and Incidence of Treatment Emergent ADA</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adat01_cache/html/setup_4f9668a83c387dcb346ab314fbb03a22">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb1-13"><a href="#cb1-13"></a>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-17"><a href="#cb1-17"></a>adab <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"A: Drug X Antibody"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">select</span>(<span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADA interpreted per sample result"</span>)</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">mutate_at</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="fu">c</span>(<span class="st">"ADA interpreted per sample result"</span>),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    as.logical</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    <span class="at">PADABLPFL =</span> <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">NADABLPFL =</span> <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patient with a positive sample at baseline"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">NADABLPFL =</span> <span class="st">"Patient with no positive samples at baseline"</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  )</span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a><span class="co"># Post Baseline Treatment Enhanced NAb positive Pts</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-54"><a href="#cb1-54"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>      <span class="st">"Treatment Emergent - Positive"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>      <span class="st">"Treatment induced ADA"</span>,</span>
+<span id="cb1-57"><a href="#cb1-57"></a>      <span class="st">"Treatment enhanced ADA"</span>,</span>
+<span id="cb1-58"><a href="#cb1-58"></a>      <span class="st">"Treatment Emergent - Negative"</span>,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>      <span class="st">"Treatment unaffected"</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>    )</span>
+<span id="cb1-61"><a href="#cb1-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb1-63"><a href="#cb1-63"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-67"><a href="#cb1-67"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-68"><a href="#cb1-68"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-69"><a href="#cb1-69"></a>    <span class="fu">across</span>(</span>
+<span id="cb1-70"><a href="#cb1-70"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb1-71"><a href="#cb1-71"></a>        <span class="st">"ADA interpreted per sample result"</span>, <span class="st">"Treatment Emergent - Positive"</span>,</span>
+<span id="cb1-72"><a href="#cb1-72"></a>        <span class="st">"Treatment induced ADA"</span>, <span class="st">"Treatment enhanced ADA"</span>,</span>
+<span id="cb1-73"><a href="#cb1-73"></a>        <span class="st">"Treatment Emergent - Negative"</span>, <span class="st">"Treatment unaffected"</span></span>
+<span id="cb1-74"><a href="#cb1-74"></a>      )),</span>
+<span id="cb1-75"><a href="#cb1-75"></a>      as.logical</span>
+<span id="cb1-76"><a href="#cb1-76"></a>    )</span>
+<span id="cb1-77"><a href="#cb1-77"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-78"><a href="#cb1-78"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-79"><a href="#cb1-79"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-80"><a href="#cb1-80"></a>    <span class="at">PTEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Positive"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Positive</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-81"><a href="#cb1-81"></a>    <span class="at">TIFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-82"><a href="#cb1-82"></a>    <span class="at">TEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment enhanced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment enhanced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-83"><a href="#cb1-83"></a>    <span class="at">NTEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Negative"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Negative</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-84"><a href="#cb1-84"></a>    <span class="at">TUFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment unaffected"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment unaffected</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb1-85"><a href="#cb1-85"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-86"><a href="#cb1-86"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-87"><a href="#cb1-87"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients"</span>,</span>
+<span id="cb1-88"><a href="#cb1-88"></a>    <span class="at">PTEFL =</span> <span class="st">"Patient positive for Treatment Emergent ADA"</span>,</span>
+<span id="cb1-89"><a href="#cb1-89"></a>    <span class="at">TIFL =</span> <span class="st">"Treatment-induced ADA"</span>,</span>
+<span id="cb1-90"><a href="#cb1-90"></a>    <span class="at">TEFL =</span> <span class="st">"Treatment-enhanced ADA"</span>,</span>
+<span id="cb1-91"><a href="#cb1-91"></a>    <span class="at">NTEFL =</span> <span class="st">"Patient negative for Treatment Emergent ADA"</span>,</span>
+<span id="cb1-92"><a href="#cb1-92"></a>    <span class="at">TUFL =</span> <span class="st">"Treatment unaffected"</span></span>
+<span id="cb1-93"><a href="#cb1-93"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="adat01_cache/html/variant1_0af54966daf7a77b869c137da0481598">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">flag_variables =</span> <span class="st">"ADABLPFL"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of ADAs"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">flag_variables =</span> <span class="st">"PADABLPFL"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">var_labels =</span> <span class="st">"a"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">flag_variables =</span> <span class="st">"NADABLPFL"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  )</span>
+<span id="cb2-31"><a href="#cb2-31"></a></span>
+<span id="cb2-32"><a href="#cb2-32"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-34"><a href="#cb2-34"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">flag_variables =</span> <span class="st">"ADPBLPFL"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of Treatment Emergent ADAs"</span>,</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb2-45"><a href="#cb2-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-47"><a href="#cb2-47"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-48"><a href="#cb2-48"></a>    <span class="at">flag_variables =</span> <span class="st">"PTEFL"</span>,</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb2-50"><a href="#cb2-50"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-51"><a href="#cb2-51"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-52"><a href="#cb2-52"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-53"><a href="#cb2-53"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-54"><a href="#cb2-54"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-55"><a href="#cb2-55"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"TIFL"</span>, <span class="st">"TEFL"</span>),</span>
+<span id="cb2-56"><a href="#cb2-56"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb2-58"><a href="#cb2-58"></a>    <span class="at">.indent_mods =</span> 2L,</span>
+<span id="cb2-59"><a href="#cb2-59"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-60"><a href="#cb2-60"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-61"><a href="#cb2-61"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-62"><a href="#cb2-62"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-63"><a href="#cb2-63"></a>    <span class="at">flag_variables =</span> <span class="st">"NTEFL"</span>,</span>
+<span id="cb2-64"><a href="#cb2-64"></a>    <span class="at">table_names =</span> <span class="st">"tb4"</span>,</span>
+<span id="cb2-65"><a href="#cb2-65"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-66"><a href="#cb2-66"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-67"><a href="#cb2-67"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-68"><a href="#cb2-68"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-69"><a href="#cb2-69"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-70"><a href="#cb2-70"></a>    <span class="at">flag_variables =</span> <span class="st">"TUFL"</span>,</span>
+<span id="cb2-71"><a href="#cb2-71"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-72"><a href="#cb2-72"></a>    <span class="at">table_names =</span> <span class="st">"tb5"</span>,</span>
+<span id="cb2-73"><a href="#cb2-73"></a>    <span class="at">.indent_mods =</span> 2L,</span>
+<span id="cb2-74"><a href="#cb2-74"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-75"><a href="#cb2-75"></a>  )</span>
+<span id="cb2-76"><a href="#cb2-76"></a></span>
+<span id="cb2-77"><a href="#cb2-77"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-78"><a href="#cb2-78"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-79"><a href="#cb2-79"></a></span>
+<span id="cb2-80"><a href="#cb2-80"></a><span class="co"># Combine tables.</span></span>
+<span id="cb2-81"><a href="#cb2-81"></a>result_1<span class="sc">@</span>col_info <span class="ot">&lt;-</span> result_2<span class="sc">@</span>col_info</span>
+<span id="cb2-82"><a href="#cb2-82"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb2-83"><a href="#cb2-83"></a></span>
+<span id="cb2-84"><a href="#cb2-84"></a><span class="co"># Change the column order.</span></span>
+<span id="cb2-85"><a href="#cb2-85"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-86"><a href="#cb2-86"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-87"><a href="#cb2-87"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-88"><a href="#cb2-88"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb2-89"><a href="#cb2-89"></a></span>
+<span id="cb2-90"><a href="#cb2-90"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-91"><a href="#cb2-91"></a>  <span class="st">"Baseline Prevalence and Incidence of Treatment Emergent ADA"</span></span>
+<span id="cb2-92"><a href="#cb2-92"></a>)</span>
+<span id="cb2-93"><a href="#cb2-93"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-94"><a href="#cb2-94"></a>  <span class="st">"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient = a patient with an ADA assay result from a baseline sample(s)</span></span>
+<span id="cb2-95"><a href="#cb2-95"></a><span class="st">  Post-baseline evaluable patient = a patient with an ADA assay result from at least one post-baseline sample Number of patients positive for Treatment Emergent</span></span>
+<span id="cb2-96"><a href="#cb2-96"></a><span class="st">  ADA = the number (and percentage) of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.</span></span>
+<span id="cb2-97"><a href="#cb2-97"></a><span class="st">  Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb2-98"><a href="#cb2-98"></a><span class="st">  Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb2-99"><a href="#cb2-99"></a><span class="st">  Number of patients negative for Treatment Emergent ADA = number of post-baseline evaluable patients with negative or missing baseline ADA result(s) and all negative post-baseline results, or a patient who is treatment unaffected.</span></span>
+<span id="cb2-100"><a href="#cb2-100"></a><span class="st">  Treatment unaffected = A post-baseline evaluable patient with a positive ADA result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing.</span></span>
+<span id="cb2-101"><a href="#cb2-101"></a><span class="st">  For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer."</span></span>
+<span id="cb2-102"><a href="#cb2-102"></a>)</span>
+<span id="cb2-103"><a href="#cb2-103"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Prevalence and Incidence of Treatment Emergent ADA
+
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                               A: Drug X    C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X 
+                                                (N=134)        (N=132)         (N=0)      (N=134)       (N=266)  
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Baseline Prevalence of ADAs                                                                                      
+  Baseline evaluable patients                     134            132             0           0            266    
+Patient with a positive sample at baseline     63 (47.0%)     64 (48.5%)        NA           NA       127 (47.7%)
+Patient with no positive samples at baseline       71             68             0           0            139    
+Incidence of Treatment Emergent ADAs                                                                             
+  Post-baseline evaluable patients                134            132             0           0            266    
+Patient positive for Treatment Emergent ADA        0              0             NA           NA            0     
+Treatment-induced ADA                              0              0              0           0             0     
+Treatment-enhanced ADA                             0              0              0           0             0     
+Patient negative for Treatment Emergent ADA        0              0             NA           NA            0     
+Treatment unaffected                               0              0              0           0             0     
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient = a patient with an ADA assay result from a baseline sample(s)
+  Post-baseline evaluable patient = a patient with an ADA assay result from at least one post-baseline sample Number of patients positive for Treatment Emergent
+  ADA = the number (and percentage) of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.
+  Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.
+  Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.
+  Number of patients negative for Treatment Emergent ADA = number of post-baseline evaluable patients with negative or missing baseline ADA result(s) and all negative post-baseline results, or a patient who is treatment unaffected.
+  Treatment unaffected = A post-baseline evaluable patient with a positive ADA result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing.
+  For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="adat01_cache/html/teal_fe3ebaa3884510abd1dc03b73b77849f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adat01_cache/html/sessioninfo_fe5199585b02b356da666b2f40d49ebb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      
+[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adat01_cache/html/snapshot_f2e226644a4b9f6ca9389b1885d2b296">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ADA/adat01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
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+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
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+      bodyEl.classList.add("quarto-light");
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+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
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+      disableStylesheet(alternateStylesheets);
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+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
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+        window.scrollTo(0, 0);
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+  // Dark / light mode switch
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+  // Ensure there is a toggle, if there isn't float one in the top right
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+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
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+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+  clipboard.on('success', function(e) {
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+      button.setAttribute("data-bs-title", "Copied!");
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> ADAT01</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Baseline Prevalence and Incidence of Treatment Emergent ADA</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb8-20"><a href="#cb8-20"></a></span>
+<span id="cb8-21"><a href="#cb8-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb8-28"><a href="#cb8-28"></a>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-32"><a href="#cb8-32"></a>adab <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"A: Drug X Antibody"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="fu">select</span>(<span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT)</span>
+<span id="cb8-35"><a href="#cb8-35"></a></span>
+<span id="cb8-36"><a href="#cb8-36"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADA interpreted per sample result"</span>)</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-47"><a href="#cb8-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="fu">mutate_at</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="fu">c</span>(<span class="st">"ADA interpreted per sample result"</span>),</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    as.logical</span>
+<span id="cb8-51"><a href="#cb8-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="at">PADABLPFL =</span> <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span>,</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="at">NADABLPFL =</span> <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patient with a positive sample at baseline"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">NADABLPFL =</span> <span class="st">"Patient with no positive samples at baseline"</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  )</span>
+<span id="cb8-62"><a href="#cb8-62"></a></span>
+<span id="cb8-63"><a href="#cb8-63"></a><span class="co"># Post Baseline Treatment Enhanced NAb positive Pts</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-66"><a href="#cb8-66"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-67"><a href="#cb8-67"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-68"><a href="#cb8-68"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb8-69"><a href="#cb8-69"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-70"><a href="#cb8-70"></a>      <span class="st">"Treatment Emergent - Positive"</span>,</span>
+<span id="cb8-71"><a href="#cb8-71"></a>      <span class="st">"Treatment induced ADA"</span>,</span>
+<span id="cb8-72"><a href="#cb8-72"></a>      <span class="st">"Treatment enhanced ADA"</span>,</span>
+<span id="cb8-73"><a href="#cb8-73"></a>      <span class="st">"Treatment Emergent - Negative"</span>,</span>
+<span id="cb8-74"><a href="#cb8-74"></a>      <span class="st">"Treatment unaffected"</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a>    )</span>
+<span id="cb8-76"><a href="#cb8-76"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-82"><a href="#cb8-82"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-84"><a href="#cb8-84"></a>    <span class="fu">across</span>(</span>
+<span id="cb8-85"><a href="#cb8-85"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb8-86"><a href="#cb8-86"></a>        <span class="st">"ADA interpreted per sample result"</span>, <span class="st">"Treatment Emergent - Positive"</span>,</span>
+<span id="cb8-87"><a href="#cb8-87"></a>        <span class="st">"Treatment induced ADA"</span>, <span class="st">"Treatment enhanced ADA"</span>,</span>
+<span id="cb8-88"><a href="#cb8-88"></a>        <span class="st">"Treatment Emergent - Negative"</span>, <span class="st">"Treatment unaffected"</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>      )),</span>
+<span id="cb8-90"><a href="#cb8-90"></a>      as.logical</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    )</span>
+<span id="cb8-92"><a href="#cb8-92"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-93"><a href="#cb8-93"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-94"><a href="#cb8-94"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-95"><a href="#cb8-95"></a>    <span class="at">PTEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Positive"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Positive</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-96"><a href="#cb8-96"></a>    <span class="at">TIFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-97"><a href="#cb8-97"></a>    <span class="at">TEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment enhanced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment enhanced ADA</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-98"><a href="#cb8-98"></a>    <span class="at">NTEFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Negative"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Negative</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    <span class="at">TUFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment unaffected"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment unaffected</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb8-100"><a href="#cb8-100"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-101"><a href="#cb8-101"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-102"><a href="#cb8-102"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients"</span>,</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="at">PTEFL =</span> <span class="st">"Patient positive for Treatment Emergent ADA"</span>,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    <span class="at">TIFL =</span> <span class="st">"Treatment-induced ADA"</span>,</span>
+<span id="cb8-105"><a href="#cb8-105"></a>    <span class="at">TEFL =</span> <span class="st">"Treatment-enhanced ADA"</span>,</span>
+<span id="cb8-106"><a href="#cb8-106"></a>    <span class="at">NTEFL =</span> <span class="st">"Patient negative for Treatment Emergent ADA"</span>,</span>
+<span id="cb8-107"><a href="#cb8-107"></a>    <span class="at">TUFL =</span> <span class="st">"Treatment unaffected"</span></span>
+<span id="cb8-108"><a href="#cb8-108"></a>  )</span>
+<span id="cb8-109"><a href="#cb8-109"></a><span class="in">```</span></span>
+<span id="cb8-110"><a href="#cb8-110"></a></span>
+<span id="cb8-111"><a href="#cb8-111"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-112"><a href="#cb8-112"></a></span>
+<span id="cb8-113"><a href="#cb8-113"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-114"><a href="#cb8-114"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb8-115"><a href="#cb8-115"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-116"><a href="#cb8-116"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-117"><a href="#cb8-117"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-118"><a href="#cb8-118"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-119"><a href="#cb8-119"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-120"><a href="#cb8-120"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-121"><a href="#cb8-121"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-122"><a href="#cb8-122"></a>    <span class="at">flag_variables =</span> <span class="st">"ADABLPFL"</span>,</span>
+<span id="cb8-123"><a href="#cb8-123"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-124"><a href="#cb8-124"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of ADAs"</span>,</span>
+<span id="cb8-125"><a href="#cb8-125"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-126"><a href="#cb8-126"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span></span>
+<span id="cb8-127"><a href="#cb8-127"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-128"><a href="#cb8-128"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-129"><a href="#cb8-129"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-130"><a href="#cb8-130"></a>    <span class="at">flag_variables =</span> <span class="st">"PADABLPFL"</span>,</span>
+<span id="cb8-131"><a href="#cb8-131"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb8-132"><a href="#cb8-132"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-133"><a href="#cb8-133"></a>    <span class="at">var_labels =</span> <span class="st">"a"</span>,</span>
+<span id="cb8-134"><a href="#cb8-134"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-135"><a href="#cb8-135"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-136"><a href="#cb8-136"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-137"><a href="#cb8-137"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-138"><a href="#cb8-138"></a>    <span class="at">flag_variables =</span> <span class="st">"NADABLPFL"</span>,</span>
+<span id="cb8-139"><a href="#cb8-139"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-140"><a href="#cb8-140"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb8-141"><a href="#cb8-141"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-142"><a href="#cb8-142"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span></span>
+<span id="cb8-143"><a href="#cb8-143"></a>  )</span>
+<span id="cb8-144"><a href="#cb8-144"></a></span>
+<span id="cb8-145"><a href="#cb8-145"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb8-146"><a href="#cb8-146"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-147"><a href="#cb8-147"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-148"><a href="#cb8-148"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-149"><a href="#cb8-149"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-150"><a href="#cb8-150"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-151"><a href="#cb8-151"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-152"><a href="#cb8-152"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-153"><a href="#cb8-153"></a>    <span class="at">flag_variables =</span> <span class="st">"ADPBLPFL"</span>,</span>
+<span id="cb8-154"><a href="#cb8-154"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-155"><a href="#cb8-155"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of Treatment Emergent ADAs"</span>,</span>
+<span id="cb8-156"><a href="#cb8-156"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-157"><a href="#cb8-157"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb8-158"><a href="#cb8-158"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-159"><a href="#cb8-159"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-160"><a href="#cb8-160"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-161"><a href="#cb8-161"></a>    <span class="at">flag_variables =</span> <span class="st">"PTEFL"</span>,</span>
+<span id="cb8-162"><a href="#cb8-162"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb8-163"><a href="#cb8-163"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-164"><a href="#cb8-164"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-165"><a href="#cb8-165"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-166"><a href="#cb8-166"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-167"><a href="#cb8-167"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-168"><a href="#cb8-168"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"TIFL"</span>, <span class="st">"TEFL"</span>),</span>
+<span id="cb8-169"><a href="#cb8-169"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-170"><a href="#cb8-170"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb8-171"><a href="#cb8-171"></a>    <span class="at">.indent_mods =</span> 2L,</span>
+<span id="cb8-172"><a href="#cb8-172"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-173"><a href="#cb8-173"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-174"><a href="#cb8-174"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-175"><a href="#cb8-175"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-176"><a href="#cb8-176"></a>    <span class="at">flag_variables =</span> <span class="st">"NTEFL"</span>,</span>
+<span id="cb8-177"><a href="#cb8-177"></a>    <span class="at">table_names =</span> <span class="st">"tb4"</span>,</span>
+<span id="cb8-178"><a href="#cb8-178"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-179"><a href="#cb8-179"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-180"><a href="#cb8-180"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-181"><a href="#cb8-181"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-182"><a href="#cb8-182"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-183"><a href="#cb8-183"></a>    <span class="at">flag_variables =</span> <span class="st">"TUFL"</span>,</span>
+<span id="cb8-184"><a href="#cb8-184"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-185"><a href="#cb8-185"></a>    <span class="at">table_names =</span> <span class="st">"tb5"</span>,</span>
+<span id="cb8-186"><a href="#cb8-186"></a>    <span class="at">.indent_mods =</span> 2L,</span>
+<span id="cb8-187"><a href="#cb8-187"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-188"><a href="#cb8-188"></a>  )</span>
+<span id="cb8-189"><a href="#cb8-189"></a></span>
+<span id="cb8-190"><a href="#cb8-190"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-191"><a href="#cb8-191"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-192"><a href="#cb8-192"></a></span>
+<span id="cb8-193"><a href="#cb8-193"></a><span class="co"># Combine tables.</span></span>
+<span id="cb8-194"><a href="#cb8-194"></a>result_1<span class="sc">@</span>col_info <span class="ot">&lt;-</span> result_2<span class="sc">@</span>col_info</span>
+<span id="cb8-195"><a href="#cb8-195"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb8-196"><a href="#cb8-196"></a></span>
+<span id="cb8-197"><a href="#cb8-197"></a><span class="co"># Change the column order.</span></span>
+<span id="cb8-198"><a href="#cb8-198"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-199"><a href="#cb8-199"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-200"><a href="#cb8-200"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-201"><a href="#cb8-201"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb8-202"><a href="#cb8-202"></a></span>
+<span id="cb8-203"><a href="#cb8-203"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-204"><a href="#cb8-204"></a>  <span class="st">"Baseline Prevalence and Incidence of Treatment Emergent ADA"</span></span>
+<span id="cb8-205"><a href="#cb8-205"></a>)</span>
+<span id="cb8-206"><a href="#cb8-206"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-207"><a href="#cb8-207"></a>  <span class="st">"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient = a patient with an ADA assay result from a baseline sample(s)</span></span>
+<span id="cb8-208"><a href="#cb8-208"></a><span class="st">  Post-baseline evaluable patient = a patient with an ADA assay result from at least one post-baseline sample Number of patients positive for Treatment Emergent</span></span>
+<span id="cb8-209"><a href="#cb8-209"></a><span class="st">  ADA = the number (and percentage) of post-baseline evaluable patients determined to have treatment-induced ADA or treatment-enhanced ADA during the study period.</span></span>
+<span id="cb8-210"><a href="#cb8-210"></a><span class="st">  Treatment-induced ADA = a patient with negative or missing baseline ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb8-211"><a href="#cb8-211"></a><span class="st">  Treatment-enhanced ADA = a patient with positive ADA result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb8-212"><a href="#cb8-212"></a><span class="st">  Number of patients negative for Treatment Emergent ADA = number of post-baseline evaluable patients with negative or missing baseline ADA result(s) and all negative post-baseline results, or a patient who is treatment unaffected.</span></span>
+<span id="cb8-213"><a href="#cb8-213"></a><span class="st">  Treatment unaffected = A post-baseline evaluable patient with a positive ADA result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing.</span></span>
+<span id="cb8-214"><a href="#cb8-214"></a><span class="st">  For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer."</span></span>
+<span id="cb8-215"><a href="#cb8-215"></a>)</span>
+<span id="cb8-216"><a href="#cb8-216"></a>result</span>
+<span id="cb8-217"><a href="#cb8-217"></a><span class="in">```</span></span>
+<span id="cb8-218"><a href="#cb8-218"></a></span>
+<span id="cb8-219"><a href="#cb8-219"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-220"><a href="#cb8-220"></a></span>
+<span id="cb8-221"><a href="#cb8-221"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-222"><a href="#cb8-222"></a></span>
+<span id="cb8-223"><a href="#cb8-223"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-224"><a href="#cb8-224"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-225"><a href="#cb8-225"></a></span>
+<span id="cb8-226"><a href="#cb8-226"></a><span class="co"># In progress</span></span>
+<span id="cb8-227"><a href="#cb8-227"></a><span class="in">```</span></span>
+<span id="cb8-228"><a href="#cb8-228"></a></span>
+<span id="cb8-229"><a href="#cb8-229"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-230"><a href="#cb8-230"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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new file mode 100644
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+++ b/stable/tables/ADA/adat02.html
@@ -0,0 +1,2251 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
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+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
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+    -khtml-user-select: none; -moz-user-select: none;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET07</span></a>
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+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Summary of Patients with Treatment-Induced ADA</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adat02_cache/html/setup_db9480edbdf3659b37e5a0035ba15556">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adab <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">mutate</span>(<span class="at">ADPBLPFL =</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span> <span class="co"># temp fix</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="sc">!</span>PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      <span class="st">"NAB Status of a patient"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>      <span class="st">"Treatment enhanced ADA"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>    )</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="fu">across</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>        <span class="st">"Treatment induced ADA"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>        <span class="st">"Transient ADA"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>        <span class="st">"Persistent ADA"</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>      )),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      as.logical</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    )</span>
+<span id="cb1-35"><a href="#cb1-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">TI_ADA =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">TI_ADA =</span> <span class="st">"Treatment-induced ADA patients"</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  )</span>
+<span id="cb1-44"><a href="#cb1-44"></a></span>
+<span id="cb1-45"><a href="#cb1-45"></a>adab_ti <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">filter</span>(TI_ADA)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="adat02_cache/html/variant1_55cbc04ea7ba567c2bb376a2f96c0fa9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Layout for post-baseline evaluable patient variables from adab dataset.</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt_adab <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> drop_split_levels</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">flag_variables =</span> <span class="st">"ADPBLPFL"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">table_names =</span> <span class="st">"post_baseline"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">flag_variables =</span> <span class="st">"TI_ADA"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  )</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a><span class="co"># Layout for treatment-induced patient variables from adab dataset.</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>lyt_adab_ti <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>, <span class="st">"&lt;Missing&gt;"</span>)) <span class="co"># temp fix</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"Transient ADA"</span>, <span class="st">"Persistent ADA"</span>),</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">var_labels =</span> <span class="st">"Treatment-induced ADA patients with"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="st">"Time to onset of ADA"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">.stats =</span> <span class="st">"median"</span>,</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">median =</span> <span class="st">"Median time to onset of ADA (weeks)"</span>)</span>
+<span id="cb2-35"><a href="#cb2-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="st">"Antibody titer units"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">.stats =</span> <span class="st">"range"</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">range =</span> <span class="st">"ADA titer range (min - max)"</span>)</span>
+<span id="cb2-41"><a href="#cb2-41"></a>  )</span>
+<span id="cb2-42"><a href="#cb2-42"></a></span>
+<span id="cb2-43"><a href="#cb2-43"></a>result_adab <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adab, <span class="at">df =</span> adab, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-44"><a href="#cb2-44"></a>result_adab_ti <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adab_ti, <span class="at">df =</span> adab_ti, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-45"><a href="#cb2-45"></a></span>
+<span id="cb2-46"><a href="#cb2-46"></a><span class="co"># Combine tables.</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a><span class="fu">col_info</span>(result_adab) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adab_ti)</span>
+<span id="cb2-48"><a href="#cb2-48"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb2-49"><a href="#cb2-49"></a>  result_adab,</span>
+<span id="cb2-50"><a href="#cb2-50"></a>  result_adab_ti</span>
+<span id="cb2-51"><a href="#cb2-51"></a>)</span>
+<span id="cb2-52"><a href="#cb2-52"></a></span>
+<span id="cb2-53"><a href="#cb2-53"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-54"><a href="#cb2-54"></a>  <span class="st">"Summary of Patients with Treatment-Induced ADA, PK Population"</span></span>
+<span id="cb2-55"><a href="#cb2-55"></a>)</span>
+<span id="cb2-56"><a href="#cb2-56"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb2-57"><a href="#cb2-57"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-58"><a href="#cb2-58"></a>  <span class="st">"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic</span></span>
+<span id="cb2-59"><a href="#cb2-59"></a><span class="st">  Antibodies)</span></span>
+<span id="cb2-60"><a href="#cb2-60"></a><span class="st">  Treatment-induced ADA = negative or missing baseline.</span></span>
+<span id="cb2-61"><a href="#cb2-61"></a><span class="st">  ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb2-62"><a href="#cb2-62"></a><span class="st">  Transient ADA = ADA positive result detected (a) at only one post-baseline</span></span>
+<span id="cb2-63"><a href="#cb2-63"></a><span class="st">  sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints</span></span>
+<span id="cb2-64"><a href="#cb2-64"></a><span class="st">  during treatment where the first and last ADA positive samples are separated</span></span>
+<span id="cb2-65"><a href="#cb2-65"></a><span class="st">  by a period of &lt; 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb2-66"><a href="#cb2-66"></a><span class="st">  Persistent ADA = ADA positive result detected (a) at the last post-baseline</span></span>
+<span id="cb2-67"><a href="#cb2-67"></a><span class="st">  sampling timepoint, OR (b) at 2 or more time points during treatment where</span></span>
+<span id="cb2-68"><a href="#cb2-68"></a><span class="st">  the first and last ADA positive samples are separated by a period ≥ 16</span></span>
+<span id="cb2-69"><a href="#cb2-69"></a><span class="st">  weeks, irrespective of any negative samples in between."</span></span>
+<span id="cb2-70"><a href="#cb2-70"></a>)</span>
+<span id="cb2-71"><a href="#cb2-71"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Patients with Treatment-Induced ADA, PK Population
+Protocol: A: Drug X Antibody
+
+—————————————————————————————————————————————————————————————————————————————
+                                      A: Drug X   C: Combination   &lt;Missing&gt; 
+                                       (N=134)       (N=132)         (N=0)   
+—————————————————————————————————————————————————————————————————————————————
+Post-baseline evaluable patients         134           132            266    
+Treatment-induced ADA patients            0             0          64 (24.1%)
+Treatment-induced ADA patients with                                          
+  Transient ADA                          NA             NA             0     
+  Persistent ADA                         NA             NA             0     
+Median time to onset of ADA (weeks)      NA             NA            0.1    
+ADA titer range (min - max)              NA             NA             NA    
+—————————————————————————————————————————————————————————————————————————————
+
+ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic
+  Antibodies)
+  Treatment-induced ADA = negative or missing baseline.
+  ADA result(s) and at least one positive post-baseline ADA result.
+  Transient ADA = ADA positive result detected (a) at only one post-baseline
+  sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints
+  during treatment where the first and last ADA positive samples are separated
+  by a period of &lt; 16 weeks, irrespective of any negative samples in between.
+  Persistent ADA = ADA positive result detected (a) at the last post-baseline
+  sampling timepoint, OR (b) at 2 or more time points during treatment where
+  the first and last ADA positive samples are separated by a period ≥ 16
+  weeks, irrespective of any negative samples in between.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="adat02_cache/html/teal_313a8eeb6740154366893cb1cc7cb77b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adat02_cache/html/sessioninfo_c194340cd4948ff0c9a8b027466616c2">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       dplyr_1.1.3      tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       
+[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  
+[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adat02_cache/html/snapshot_77c6c973394491077939e44e384b9b95">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ADA/adat02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    if (citeInfo) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ADA/adat01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ADAT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/ADA/adat03.html" class="pagination-link">
+        <span class="nav-page-text">ADAT03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> ADAT02</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Summary of Patients with Treatment-Induced ADA</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a></span>
+<span id="cb8-23"><a href="#cb8-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-25"><a href="#cb8-25"></a>adab <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="fu">mutate</span>(<span class="at">ADPBLPFL =</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span> <span class="co"># temp fix</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="sc">!</span>PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>      <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>      <span class="st">"NAB Status of a patient"</span>,</span>
+<span id="cb8-32"><a href="#cb8-32"></a>      <span class="st">"Treatment enhanced ADA"</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>    )</span>
+<span id="cb8-34"><a href="#cb8-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="fu">across</span>(</span>
+<span id="cb8-43"><a href="#cb8-43"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>        <span class="st">"Treatment induced ADA"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>        <span class="st">"Transient ADA"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>        <span class="st">"Persistent ADA"</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>      )),</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      as.logical</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    )</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="at">TI_ADA =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA</span><span class="st">`</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients"</span>,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">TI_ADA =</span> <span class="st">"Treatment-induced ADA patients"</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  )</span>
+<span id="cb8-59"><a href="#cb8-59"></a></span>
+<span id="cb8-60"><a href="#cb8-60"></a>adab_ti <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">filter</span>(TI_ADA)</span>
+<span id="cb8-62"><a href="#cb8-62"></a><span class="in">```</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a></span>
+<span id="cb8-66"><a href="#cb8-66"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a><span class="co"># Layout for post-baseline evaluable patient variables from adab dataset.</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>lyt_adab <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-70"><a href="#cb8-70"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-71"><a href="#cb8-71"></a>    <span class="at">split_fun =</span> drop_split_levels</span>
+<span id="cb8-72"><a href="#cb8-72"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-74"><a href="#cb8-74"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-75"><a href="#cb8-75"></a>    <span class="at">flag_variables =</span> <span class="st">"ADPBLPFL"</span>,</span>
+<span id="cb8-76"><a href="#cb8-76"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-77"><a href="#cb8-77"></a>    <span class="at">table_names =</span> <span class="st">"post_baseline"</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    <span class="at">flag_variables =</span> <span class="st">"TI_ADA"</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a>  )</span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a><span class="co"># Layout for treatment-induced patient variables from adab dataset.</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>lyt_adab_ti <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-86"><a href="#cb8-86"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-87"><a href="#cb8-87"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-88"><a href="#cb8-88"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>, <span class="st">"&lt;Missing&gt;"</span>)) <span class="co"># temp fix</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-90"><a href="#cb8-90"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-92"><a href="#cb8-92"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"Transient ADA"</span>, <span class="st">"Persistent ADA"</span>),</span>
+<span id="cb8-93"><a href="#cb8-93"></a>    <span class="at">var_labels =</span> <span class="st">"Treatment-induced ADA patients with"</span>,</span>
+<span id="cb8-94"><a href="#cb8-94"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-95"><a href="#cb8-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-97"><a href="#cb8-97"></a>    <span class="st">"Time to onset of ADA"</span>,</span>
+<span id="cb8-98"><a href="#cb8-98"></a>    <span class="at">.stats =</span> <span class="st">"median"</span>,</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-100"><a href="#cb8-100"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">median =</span> <span class="st">"Median time to onset of ADA (weeks)"</span>)</span>
+<span id="cb8-101"><a href="#cb8-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-102"><a href="#cb8-102"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="st">"Antibody titer units"</span>,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    <span class="at">.stats =</span> <span class="st">"range"</span>,</span>
+<span id="cb8-105"><a href="#cb8-105"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-106"><a href="#cb8-106"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">range =</span> <span class="st">"ADA titer range (min - max)"</span>)</span>
+<span id="cb8-107"><a href="#cb8-107"></a>  )</span>
+<span id="cb8-108"><a href="#cb8-108"></a></span>
+<span id="cb8-109"><a href="#cb8-109"></a>result_adab <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adab, <span class="at">df =</span> adab, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-110"><a href="#cb8-110"></a>result_adab_ti <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adab_ti, <span class="at">df =</span> adab_ti, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-111"><a href="#cb8-111"></a></span>
+<span id="cb8-112"><a href="#cb8-112"></a><span class="co"># Combine tables.</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a><span class="fu">col_info</span>(result_adab) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adab_ti)</span>
+<span id="cb8-114"><a href="#cb8-114"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb8-115"><a href="#cb8-115"></a>  result_adab,</span>
+<span id="cb8-116"><a href="#cb8-116"></a>  result_adab_ti</span>
+<span id="cb8-117"><a href="#cb8-117"></a>)</span>
+<span id="cb8-118"><a href="#cb8-118"></a></span>
+<span id="cb8-119"><a href="#cb8-119"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-120"><a href="#cb8-120"></a>  <span class="st">"Summary of Patients with Treatment-Induced ADA, PK Population"</span></span>
+<span id="cb8-121"><a href="#cb8-121"></a>)</span>
+<span id="cb8-122"><a href="#cb8-122"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb8-123"><a href="#cb8-123"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-124"><a href="#cb8-124"></a>  <span class="st">"ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic</span></span>
+<span id="cb8-125"><a href="#cb8-125"></a><span class="st">  Antibodies)</span></span>
+<span id="cb8-126"><a href="#cb8-126"></a><span class="st">  Treatment-induced ADA = negative or missing baseline.</span></span>
+<span id="cb8-127"><a href="#cb8-127"></a><span class="st">  ADA result(s) and at least one positive post-baseline ADA result.</span></span>
+<span id="cb8-128"><a href="#cb8-128"></a><span class="st">  Transient ADA = ADA positive result detected (a) at only one post-baseline</span></span>
+<span id="cb8-129"><a href="#cb8-129"></a><span class="st">  sampling timepoint (excluding last timepoint) OR (b) at 2 or more timepoints</span></span>
+<span id="cb8-130"><a href="#cb8-130"></a><span class="st">  during treatment where the first and last ADA positive samples are separated</span></span>
+<span id="cb8-131"><a href="#cb8-131"></a><span class="st">  by a period of &lt; 16 weeks, irrespective of any negative samples in between.</span></span>
+<span id="cb8-132"><a href="#cb8-132"></a><span class="st">  Persistent ADA = ADA positive result detected (a) at the last post-baseline</span></span>
+<span id="cb8-133"><a href="#cb8-133"></a><span class="st">  sampling timepoint, OR (b) at 2 or more time points during treatment where</span></span>
+<span id="cb8-134"><a href="#cb8-134"></a><span class="st">  the first and last ADA positive samples are separated by a period ≥ 16</span></span>
+<span id="cb8-135"><a href="#cb8-135"></a><span class="st">  weeks, irrespective of any negative samples in between."</span></span>
+<span id="cb8-136"><a href="#cb8-136"></a>)</span>
+<span id="cb8-137"><a href="#cb8-137"></a>result</span>
+<span id="cb8-138"><a href="#cb8-138"></a><span class="in">```</span></span>
+<span id="cb8-139"><a href="#cb8-139"></a></span>
+<span id="cb8-140"><a href="#cb8-140"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-141"><a href="#cb8-141"></a></span>
+<span id="cb8-142"><a href="#cb8-142"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-143"><a href="#cb8-143"></a></span>
+<span id="cb8-144"><a href="#cb8-144"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-145"><a href="#cb8-145"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-146"><a href="#cb8-146"></a></span>
+<span id="cb8-147"><a href="#cb8-147"></a><span class="co"># In progress</span></span>
+<span id="cb8-148"><a href="#cb8-148"></a><span class="in">```</span></span>
+<span id="cb8-149"><a href="#cb8-149"></a></span>
+<span id="cb8-150"><a href="#cb8-150"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-151"><a href="#cb8-151"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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new file mode 100644
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+++ b/stable/tables/ADA/adat03.html
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+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
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+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Summary of Serum Concentrations at Timepoints Where ADA Samples Were Collected and Analyzed</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table (μg/mL)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adat03_cache/html/setup_9a470b4718f491a59b0e83db3b6643d9">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adab <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>adpc <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adpc)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="co"># Adjust zzz parameter</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>max_conc <span class="ot">&lt;-</span> <span class="dv">15</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>adpc <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span> <span class="fu">select</span>(USUBJID, NFRLT, AVAL, AVALU, AVALCAT1)</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>anl <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">filter</span>(., PARAM <span class="sc">==</span> <span class="st">"ADA interpreted per sample result"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">select</span>(<span class="sc">-</span>AVAL, AVALC, AVALU)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a>anl <span class="ot">&lt;-</span> <span class="fu">merge</span>(anl, adpc, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"NFRLT"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_LT =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">&lt;=</span> max_conc, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="adat03_cache/html/variant1_fbc3d1a377148dfe1c0fe653992f1839">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># parameters in columns</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>adat03_stats <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"median"</span>, <span class="st">"min"</span>, <span class="st">"max"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"count_fraction"</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a>adat03_lbls <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">n =</span> <span class="st">"Total Number</span><span class="sc">\n</span><span class="st">of Measurable</span><span class="sc">\n</span><span class="st"> Samples"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">max =</span> <span class="st">"Maximum"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="at">count_fraction =</span> <span class="fu">paste0</span>(<span class="st">"Samples with</span><span class="sc">\n</span><span class="st">Concentration</span><span class="sc">\n</span><span class="st">≤ "</span>, max_conc, <span class="st">"μg/mL"</span>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>)</span>
+<span id="cb2-14"><a href="#cb2-14"></a>adat03_fmts <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">count_fraction =</span> format_count_fraction</span>
+<span id="cb2-24"><a href="#cb2-24"></a>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>afun_list <span class="ot">&lt;-</span> <span class="fu">lapply</span>(</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="dv">1</span><span class="sc">:</span><span class="dv">9</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="cf">function</span>(i) <span class="fu">make_afun</span>(s_summary, <span class="at">.stats =</span> adat03_stats[i], <span class="at">.formats =</span> adat03_fmts[i], <span class="at">.labels =</span> <span class="st">"Overall"</span>)</span>
+<span id="cb2-29"><a href="#cb2-29"></a>)</span>
+<span id="cb2-30"><a href="#cb2-30"></a></span>
+<span id="cb2-31"><a href="#cb2-31"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">section_div =</span> <span class="st">""</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">var =</span> <span class="st">"VISIT"</span>,</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">split_label =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-46"><a href="#cb2-46"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-48"><a href="#cb2-48"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"AVAL"</span>, <span class="dv">8</span>), <span class="st">"AVAL_LT"</span>),</span>
+<span id="cb2-50"><a href="#cb2-50"></a>    <span class="at">.stats =</span> adat03_stats,</span>
+<span id="cb2-51"><a href="#cb2-51"></a>    <span class="at">.labels =</span> adat03_lbls,</span>
+<span id="cb2-52"><a href="#cb2-52"></a>    <span class="at">.formats =</span> adat03_fmts</span>
+<span id="cb2-53"><a href="#cb2-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-54"><a href="#cb2-54"></a>  <span class="fu">analyze_colvars</span>(</span>
+<span id="cb2-55"><a href="#cb2-55"></a>    afun_list,</span>
+<span id="cb2-56"><a href="#cb2-56"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">extra_args =</span> <span class="fu">list</span>(<span class="st">".labels"</span> <span class="ot">=</span> <span class="st">"Overall"</span>)</span>
+<span id="cb2-58"><a href="#cb2-58"></a>  )</span>
+<span id="cb2-59"><a href="#cb2-59"></a></span>
+<span id="cb2-60"><a href="#cb2-60"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-61"><a href="#cb2-61"></a></span>
+<span id="cb2-62"><a href="#cb2-62"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-63"><a href="#cb2-63"></a>  <span class="st">"Summary of Serum Concentrations (μg/mL) at Timepoints Where ADA Samples Were Collected and Analyzed</span><span class="sc">\n</span></span>
+<span id="cb2-64"><a href="#cb2-64"></a><span class="st">  Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>]</span>
+<span id="cb2-65"><a href="#cb2-65"></a>)</span>
+<span id="cb2-66"><a href="#cb2-66"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>])</span>
+<span id="cb2-67"><a href="#cb2-67"></a><span class="fu">fnotes_at_path</span>(result, <span class="at">rowpath =</span> <span class="cn">NULL</span>, <span class="at">colpath =</span> <span class="fu">c</span>(<span class="st">"multivars"</span>, <span class="st">"AVAL"</span>)) <span class="ot">&lt;-</span> <span class="st">"Refers to the total no. of measurable ADA samples that have a corresponding measurable drug concentration sample (i.e. results with</span></span>
+<span id="cb2-68"><a href="#cb2-68"></a><span class="st">valid numeric values and LTRs). LTR results on post-dose samples are replaced by aaa µg/mL i.e. half of MQC value."</span></span>
+<span id="cb2-69"><a href="#cb2-69"></a><span class="fu">fnotes_at_path</span>(result, <span class="at">rowpath =</span> <span class="cn">NULL</span>, <span class="at">colpath =</span> <span class="fu">c</span>(<span class="st">"multivars"</span>, <span class="st">"AVAL_LT"</span>)) <span class="ot">&lt;-</span> <span class="st">"In validation, the assay was able to detect yyy ng/mL of surrogate ADA in the presence of zzz µg/mL of [drug]. BLQ = Below Limit of</span></span>
+<span id="cb2-70"><a href="#cb2-70"></a><span class="st">Quantitation, LTR = Lower than Reportable, MQC = Minimum Quantifiable Concentration, ADA = Anti-Drug Antibodies (is also referred to as ATA,</span></span>
+<span id="cb2-71"><a href="#cb2-71"></a><span class="st">or Anti-Therapeutic Antibodies). RXXXXXXX is also known as [drug]"</span></span>
+<span id="cb2-72"><a href="#cb2-72"></a></span>
+<span id="cb2-73"><a href="#cb2-73"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Serum Concentrations (μg/mL) at Timepoints Where ADA Samples Were Collected and Analyzed
+
+  Protocol: A: Drug X Antibody
+Analyte: R1800000
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Group                                                                                                                             
+  Visit                  Total Number                                                                                          Samples with 
+                         of Measurable                                                                                         Concentration
+                          Samples {1}      Mean         SD        Median      Minimum     Maximum    CV (%)   Geometric Mean   ≤ 15μg/mL {2}
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+A: Drug X (N=536)                                                                                                                           
+  Day 1                       402        0.000e+00   0.000e+00   0.000e+00   0.000e+00   0.000e+00     NA           NA          402 (100%)  
+  Day 2                       134        1.618e+01   1.626e+00   1.619e+01   1.260e+01   1.986e+01    10.0      1.610e+01       39 (29.1%)  
+
+C: Combination (N=792)                                                                                                                      
+  Day 1                       528        0.000e+00   0.000e+00   0.000e+00   0.000e+00   0.000e+00     NA           NA          528 (100%)  
+  Day 2                       264        2.468e+01   8.645e+00   2.251e+01   1.264e+01   3.947e+01    35.0      2.315e+01       28 (10.6%)  
+
+Overall                      1328        6.540e+00   1.095e+01   0.000e+00   0.000e+00   3.947e+01   167.5          NA          997 (75.1%) 
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+{1} - Refers to the total no. of measurable ADA samples that have a corresponding measurable drug concentration sample (i.e. results with
+valid numeric values and LTRs). LTR results on post-dose samples are replaced by aaa µg/mL i.e. half of MQC value.
+{2} - In validation, the assay was able to detect yyy ng/mL of surrogate ADA in the presence of zzz µg/mL of [drug]. BLQ = Below Limit of
+Quantitation, LTR = Lower than Reportable, MQC = Minimum Quantifiable Concentration, ADA = Anti-Drug Antibodies (is also referred to as ATA,
+or Anti-Therapeutic Antibodies). RXXXXXXX is also known as [drug]
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="adat03_cache/html/teal_3fe65ff2a9470d14172e98cdd14e65b8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adat03_cache/html/sessioninfo_7f41aafbefa15428b832701fd1a26954">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] scda_0.1.6       dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       
+[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  
+[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adat03_cache/html/snapshot_4dd0108b6d002cca16891ab72f7c7877">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ADA/adat03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
+    } else {
+      localAlternateSentinel = value;
+    }
+  }
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> ADAT03</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Summary of Serum Concentrations at Timepoints Where ADA Samples Were Collected and Analyzed</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>adpc <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpc"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-26"><a href="#cb8-26"></a>adab <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab)</span>
+<span id="cb8-27"><a href="#cb8-27"></a>adpc <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adpc)</span>
+<span id="cb8-28"><a href="#cb8-28"></a></span>
+<span id="cb8-29"><a href="#cb8-29"></a><span class="co"># Adjust zzz parameter</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>max_conc <span class="ot">&lt;-</span> <span class="dv">15</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a></span>
+<span id="cb8-32"><a href="#cb8-32"></a>adpc <span class="ot">&lt;-</span> adpc <span class="sc">%&gt;%</span> <span class="fu">select</span>(USUBJID, NFRLT, AVAL, AVALU, AVALCAT1)</span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a>anl <span class="ot">&lt;-</span> adab <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">filter</span>(., PARAM <span class="sc">==</span> <span class="st">"ADA interpreted per sample result"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">select</span>(<span class="sc">-</span>AVAL, AVALC, AVALU)</span>
+<span id="cb8-37"><a href="#cb8-37"></a></span>
+<span id="cb8-38"><a href="#cb8-38"></a>anl <span class="ot">&lt;-</span> <span class="fu">merge</span>(anl, adpc, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"NFRLT"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  <span class="fu">mutate</span>(<span class="at">AVAL_LT =</span> <span class="fu">ifelse</span>(AVAL <span class="sc">&lt;=</span> max_conc, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>))</span>
+<span id="cb8-40"><a href="#cb8-40"></a><span class="in">```</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a></span>
+<span id="cb8-42"><a href="#cb8-42"></a><span class="fu">## Standard Table (μg/mL)</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a></span>
+<span id="cb8-44"><a href="#cb8-44"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a><span class="co"># parameters in columns</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>adat03_stats <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"median"</span>, <span class="st">"min"</span>, <span class="st">"max"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"count_fraction"</span>)</span>
+<span id="cb8-47"><a href="#cb8-47"></a>adat03_lbls <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="at">n =</span> <span class="st">"Total Number</span><span class="sc">\n</span><span class="st">of Measurable</span><span class="sc">\n</span><span class="st"> Samples"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>  <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>  <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb8-53"><a href="#cb8-53"></a>  <span class="at">max =</span> <span class="st">"Maximum"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>  <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb8-55"><a href="#cb8-55"></a>  <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="at">count_fraction =</span> <span class="fu">paste0</span>(<span class="st">"Samples with</span><span class="sc">\n</span><span class="st">Concentration</span><span class="sc">\n</span><span class="st">≤ "</span>, max_conc, <span class="st">"μg/mL"</span>)</span>
+<span id="cb8-57"><a href="#cb8-57"></a>)</span>
+<span id="cb8-58"><a href="#cb8-58"></a>adat03_fmts <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb8-59"><a href="#cb8-59"></a>  <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-62"><a href="#cb8-62"></a>  <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>  <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-64"><a href="#cb8-64"></a>  <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb8-66"><a href="#cb8-66"></a>  <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-67"><a href="#cb8-67"></a>  <span class="at">count_fraction =</span> format_count_fraction</span>
+<span id="cb8-68"><a href="#cb8-68"></a>)</span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a>afun_list <span class="ot">&lt;-</span> <span class="fu">lapply</span>(</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="dv">1</span><span class="sc">:</span><span class="dv">9</span>,</span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="cf">function</span>(i) <span class="fu">make_afun</span>(s_summary, <span class="at">.stats =</span> adat03_stats[i], <span class="at">.formats =</span> adat03_fmts[i], <span class="at">.labels =</span> <span class="st">"Overall"</span>)</span>
+<span id="cb8-73"><a href="#cb8-73"></a>)</span>
+<span id="cb8-74"><a href="#cb8-74"></a></span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="co"># lyt creation</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-78"><a href="#cb8-78"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Group"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb8-82"><a href="#cb8-82"></a>    <span class="at">section_div =</span> <span class="st">""</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-86"><a href="#cb8-86"></a>    <span class="at">var =</span> <span class="st">"VISIT"</span>,</span>
+<span id="cb8-87"><a href="#cb8-87"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-88"><a href="#cb8-88"></a>    <span class="at">split_label =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb8-89"><a href="#cb8-89"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb8-90"><a href="#cb8-90"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-91"><a href="#cb8-91"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-92"><a href="#cb8-92"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb8-93"><a href="#cb8-93"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"AVAL"</span>, <span class="dv">8</span>), <span class="st">"AVAL_LT"</span>),</span>
+<span id="cb8-94"><a href="#cb8-94"></a>    <span class="at">.stats =</span> adat03_stats,</span>
+<span id="cb8-95"><a href="#cb8-95"></a>    <span class="at">.labels =</span> adat03_lbls,</span>
+<span id="cb8-96"><a href="#cb8-96"></a>    <span class="at">.formats =</span> adat03_fmts</span>
+<span id="cb8-97"><a href="#cb8-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-98"><a href="#cb8-98"></a>  <span class="fu">analyze_colvars</span>(</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    afun_list,</span>
+<span id="cb8-100"><a href="#cb8-100"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-101"><a href="#cb8-101"></a>    <span class="at">extra_args =</span> <span class="fu">list</span>(<span class="st">".labels"</span> <span class="ot">=</span> <span class="st">"Overall"</span>)</span>
+<span id="cb8-102"><a href="#cb8-102"></a>  )</span>
+<span id="cb8-103"><a href="#cb8-103"></a></span>
+<span id="cb8-104"><a href="#cb8-104"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-105"><a href="#cb8-105"></a></span>
+<span id="cb8-106"><a href="#cb8-106"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-107"><a href="#cb8-107"></a>  <span class="st">"Summary of Serum Concentrations (μg/mL) at Timepoints Where ADA Samples Were Collected and Analyzed</span><span class="sc">\n</span></span>
+<span id="cb8-108"><a href="#cb8-108"></a><span class="st">  Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>]</span>
+<span id="cb8-109"><a href="#cb8-109"></a>)</span>
+<span id="cb8-110"><a href="#cb8-110"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARAMCD)[<span class="dv">1</span>])</span>
+<span id="cb8-111"><a href="#cb8-111"></a><span class="fu">fnotes_at_path</span>(result, <span class="at">rowpath =</span> <span class="cn">NULL</span>, <span class="at">colpath =</span> <span class="fu">c</span>(<span class="st">"multivars"</span>, <span class="st">"AVAL"</span>)) <span class="ot">&lt;-</span> <span class="st">"Refers to the total no. of measurable ADA samples that have a corresponding measurable drug concentration sample (i.e. results with</span></span>
+<span id="cb8-112"><a href="#cb8-112"></a><span class="st">valid numeric values and LTRs). LTR results on post-dose samples are replaced by aaa µg/mL i.e. half of MQC value."</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a><span class="fu">fnotes_at_path</span>(result, <span class="at">rowpath =</span> <span class="cn">NULL</span>, <span class="at">colpath =</span> <span class="fu">c</span>(<span class="st">"multivars"</span>, <span class="st">"AVAL_LT"</span>)) <span class="ot">&lt;-</span> <span class="st">"In validation, the assay was able to detect yyy ng/mL of surrogate ADA in the presence of zzz µg/mL of [drug]. BLQ = Below Limit of</span></span>
+<span id="cb8-114"><a href="#cb8-114"></a><span class="st">Quantitation, LTR = Lower than Reportable, MQC = Minimum Quantifiable Concentration, ADA = Anti-Drug Antibodies (is also referred to as ATA,</span></span>
+<span id="cb8-115"><a href="#cb8-115"></a><span class="st">or Anti-Therapeutic Antibodies). RXXXXXXX is also known as [drug]"</span></span>
+<span id="cb8-116"><a href="#cb8-116"></a></span>
+<span id="cb8-117"><a href="#cb8-117"></a>result</span>
+<span id="cb8-118"><a href="#cb8-118"></a><span class="in">```</span></span>
+<span id="cb8-119"><a href="#cb8-119"></a></span>
+<span id="cb8-120"><a href="#cb8-120"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-121"><a href="#cb8-121"></a></span>
+<span id="cb8-122"><a href="#cb8-122"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-123"><a href="#cb8-123"></a></span>
+<span id="cb8-124"><a href="#cb8-124"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-125"><a href="#cb8-125"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-126"><a href="#cb8-126"></a></span>
+<span id="cb8-127"><a href="#cb8-127"></a><span class="co"># In progress</span></span>
+<span id="cb8-128"><a href="#cb8-128"></a><span class="in">```</span></span>
+<span id="cb8-129"><a href="#cb8-129"></a></span>
+<span id="cb8-130"><a href="#cb8-130"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-131"><a href="#cb8-131"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/tables/ADA/adat04a.html b/stable/tables/ADA/adat04a.html
new file mode 100644
index 0000000000..2cd3dccfa1
--- /dev/null
+++ b/stable/tables/ADA/adat04a.html
@@ -0,0 +1,2432 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - ADAT04A</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
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+<meta property="og:description" content="Baseline Prevalence and Incidence of Treatment Emergent NAbs">
+<meta property="og:site-name" content="TLG Catalog">
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+<body class="nav-sidebar docked nav-fixed">
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+</i> 
+ <span class="menu-text"></span></a>
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+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/ADA/adat01.html">ADA</a></li><li class="breadcrumb-item"><a href="../../tables/ADA/adat04a.html">ADAT04A</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
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+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAT04A</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Baseline Prevalence and Incidence of Treatment Emergent NAbs</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Summary of Treatment Emergent NAbs</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adat04a_cache/html/setup_9d744c51553887fc4f619ce87d4cd233">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb1-13"><a href="#cb1-13"></a>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>    )</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="fu">across</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>        <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>      )),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      as.logical</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    )</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">PADABLPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">PNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">NNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients for ADA"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patients with a positive ADA sample at baseline"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    <span class="at">PNABBLFL =</span> <span class="st">"Patients with a positive NAb sample at baseline"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">NNABBLFL =</span> <span class="st">"Patient with no positive NAb samples at baseline"</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  )</span>
+<span id="cb1-54"><a href="#cb1-54"></a></span>
+<span id="cb1-55"><a href="#cb1-55"></a><span class="co"># Post Baseline Treatment Enhanced NAb positive Pts</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-61"><a href="#cb1-61"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>      <span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>      <span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb1-64"><a href="#cb1-64"></a>      <span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>      <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>      <span class="st">"Treatment unaffected, Neutralizing Antibody"</span></span>
+<span id="cb1-67"><a href="#cb1-67"></a>    )</span>
+<span id="cb1-68"><a href="#cb1-68"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb1-70"><a href="#cb1-70"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-71"><a href="#cb1-71"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-72"><a href="#cb1-72"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-73"><a href="#cb1-73"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-74"><a href="#cb1-74"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-75"><a href="#cb1-75"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-76"><a href="#cb1-76"></a>    <span class="fu">across</span>(</span>
+<span id="cb1-77"><a href="#cb1-77"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb1-78"><a href="#cb1-78"></a>        <span class="st">"ADA interpreted per sample result"</span>, <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb1-79"><a href="#cb1-79"></a>        <span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>,</span>
+<span id="cb1-80"><a href="#cb1-80"></a>        <span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb1-81"><a href="#cb1-81"></a>        <span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb1-82"><a href="#cb1-82"></a>        <span class="st">"Treatment unaffected, Neutralizing Antibody"</span></span>
+<span id="cb1-83"><a href="#cb1-83"></a>      )),</span>
+<span id="cb1-84"><a href="#cb1-84"></a>      as.logical</span>
+<span id="cb1-85"><a href="#cb1-85"></a>    )</span>
+<span id="cb1-86"><a href="#cb1-86"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-87"><a href="#cb1-87"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-88"><a href="#cb1-88"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-89"><a href="#cb1-89"></a>    <span class="at">ADAPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-90"><a href="#cb1-90"></a>    <span class="at">TENABPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Positive, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-91"><a href="#cb1-91"></a>    <span class="at">TINPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-92"><a href="#cb1-92"></a>    <span class="at">TENPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment enhanced ADA, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-93"><a href="#cb1-93"></a>    <span class="at">NABNFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-94"><a href="#cb1-94"></a>    <span class="at">TUNPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment unaffected, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment unaffected, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb1-95"><a href="#cb1-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-96"><a href="#cb1-96"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-97"><a href="#cb1-97"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients for ADA"</span>,</span>
+<span id="cb1-98"><a href="#cb1-98"></a>    <span class="at">ADAPFL =</span> <span class="st">"Patients positive for ADA"</span>,</span>
+<span id="cb1-99"><a href="#cb1-99"></a>    <span class="at">TENABPFL =</span> <span class="st">"Patients positive for Treatment Emergent NAb"</span>,</span>
+<span id="cb1-100"><a href="#cb1-100"></a>    <span class="at">TINPBFL =</span> <span class="st">"Treatment-induced NAb"</span>,</span>
+<span id="cb1-101"><a href="#cb1-101"></a>    <span class="at">TENPBFL =</span> <span class="st">"Treatment-enhanced NAb"</span>,</span>
+<span id="cb1-102"><a href="#cb1-102"></a>    <span class="at">NABNFL =</span> <span class="st">"Patients negative for NAb"</span>,</span>
+<span id="cb1-103"><a href="#cb1-103"></a>    <span class="at">TUNPBFL =</span> <span class="st">"Treatment unaffected"</span></span>
+<span id="cb1-104"><a href="#cb1-104"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="adat04a_cache/html/variant1_e98c94289989f91bf29d3e28684ef6ed">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADABLPFL"</span>, <span class="st">"PADABLPFL"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of NAbs"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">flag_variables =</span> <span class="st">"PNABBLFL"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">.indent_mods =</span> 1L</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">flag_variables =</span> <span class="st">"NNABBLFL"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  )</span>
+<span id="cb2-29"><a href="#cb2-29"></a></span>
+<span id="cb2-30"><a href="#cb2-30"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-35"><a href="#cb2-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADPBLPFL"</span>, <span class="st">"ADAPFL"</span>),</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of Treatment Emergent NAbs"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb2-43"><a href="#cb2-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-46"><a href="#cb2-46"></a>    <span class="at">flag_variables =</span> <span class="st">"TENABPFL"</span>,</span>
+<span id="cb2-47"><a href="#cb2-47"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb2-48"><a href="#cb2-48"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-50"><a href="#cb2-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-51"><a href="#cb2-51"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-52"><a href="#cb2-52"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-53"><a href="#cb2-53"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"TINPBFL"</span>, <span class="st">"TENPBFL"</span>),</span>
+<span id="cb2-54"><a href="#cb2-54"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-55"><a href="#cb2-55"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb2-56"><a href="#cb2-56"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-58"><a href="#cb2-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-59"><a href="#cb2-59"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-60"><a href="#cb2-60"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-61"><a href="#cb2-61"></a>    <span class="at">flag_variables =</span> <span class="st">"NABNFL"</span>,</span>
+<span id="cb2-62"><a href="#cb2-62"></a>    <span class="at">table_names =</span> <span class="st">"tb4"</span>,</span>
+<span id="cb2-63"><a href="#cb2-63"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-64"><a href="#cb2-64"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-65"><a href="#cb2-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-66"><a href="#cb2-66"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-67"><a href="#cb2-67"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-68"><a href="#cb2-68"></a>    <span class="at">flag_variables =</span> <span class="st">"TUNPBFL"</span>,</span>
+<span id="cb2-69"><a href="#cb2-69"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-70"><a href="#cb2-70"></a>    <span class="at">table_names =</span> <span class="st">"tb5"</span>,</span>
+<span id="cb2-71"><a href="#cb2-71"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-72"><a href="#cb2-72"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-73"><a href="#cb2-73"></a>  )</span>
+<span id="cb2-74"><a href="#cb2-74"></a></span>
+<span id="cb2-75"><a href="#cb2-75"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-76"><a href="#cb2-76"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-77"><a href="#cb2-77"></a></span>
+<span id="cb2-78"><a href="#cb2-78"></a><span class="co"># Combine tables</span></span>
+<span id="cb2-79"><a href="#cb2-79"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb2-80"><a href="#cb2-80"></a></span>
+<span id="cb2-81"><a href="#cb2-81"></a><span class="co"># Change the column order</span></span>
+<span id="cb2-82"><a href="#cb2-82"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-83"><a href="#cb2-83"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-84"><a href="#cb2-84"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-85"><a href="#cb2-85"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb2-86"><a href="#cb2-86"></a></span>
+<span id="cb2-87"><a href="#cb2-87"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-88"><a href="#cb2-88"></a>  <span class="st">"Baseline Prevalence and Incidence of Treatment Emergent NAbs"</span></span>
+<span id="cb2-89"><a href="#cb2-89"></a>)</span>
+<span id="cb2-90"><a href="#cb2-90"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb2-91"><a href="#cb2-91"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-92"><a href="#cb2-92"></a>  <span class="st">"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s)</span></span>
+<span id="cb2-93"><a href="#cb2-93"></a><span class="st">  Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s)</span></span>
+<span id="cb2-94"><a href="#cb2-94"></a><span class="st">  Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample</span></span>
+<span id="cb2-95"><a href="#cb2-95"></a><span class="st">  Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample</span></span>
+<span id="cb2-96"><a href="#cb2-96"></a><span class="st">  Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.</span></span>
+<span id="cb2-97"><a href="#cb2-97"></a><span class="st">Number of patients positive for Treatment Emergent NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have treatment-induced NAb or treatment-enhanced NAb during the study period.</span></span>
+<span id="cb2-98"><a href="#cb2-98"></a><span class="st">Treatment-induced = a patient with negative or missing baseline result(s) and at least one positive post-baseline result. Treatment-enhanced = a patient with positive result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb2-99"><a href="#cb2-99"></a><span class="st">Number of patients negative for Treatment Emergent NAb = number of post-baseline evaluable patients with negative or missing baseline NAb result(s) and all negative post-baseline NAb results, or a patient who is NAb treatment unaffected.</span></span>
+<span id="cb2-100"><a href="#cb2-100"></a><span class="st">Treatment unaffected = A post-baseline evaluable patient with a positive result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing. For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer."</span></span>
+<span id="cb2-101"><a href="#cb2-101"></a>)</span>
+<span id="cb2-102"><a href="#cb2-102"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Prevalence and Incidence of Treatment Emergent NAbs
+Protocol: A: Drug X Antibody
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                    A: Drug X   C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X
+                                                     (N=134)       (N=132)         (N=0)      (N=134)      (N=266)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Baseline Prevalence of NAbs                                                                                         
+  Baseline evaluable patients for ADA                  134           132             0           0           266    
+  Patients with a positive ADA sample at baseline      63             64             0           0           127    
+Patients with a positive NAb sample at baseline         0             0             NA           NA           0     
+Patient with no positive NAb samples at baseline        0             0              0           0            0     
+Incidence of Treatment Emergent NAbs                                                                                
+  Post-baseline evaluable patients for ADA             134           132             0           0           266    
+  Patients positive for ADA                            66             59             0           0           125    
+Patients positive for Treatment Emergent NAb            0             0             NA           NA           0     
+Treatment-induced NAb                                   0             0              0           0            0     
+Treatment-enhanced NAb                                  0             0              0           0            0     
+Patients negative for NAb                               0             0             NA           NA           0     
+Treatment unaffected                                    0             0              0           0            0     
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s)
+  Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s)
+  Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample
+  Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample
+  Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.
+Number of patients positive for Treatment Emergent NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have treatment-induced NAb or treatment-enhanced NAb during the study period.
+Treatment-induced = a patient with negative or missing baseline result(s) and at least one positive post-baseline result. Treatment-enhanced = a patient with positive result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.
+Number of patients negative for Treatment Emergent NAb = number of post-baseline evaluable patients with negative or missing baseline NAb result(s) and all negative post-baseline NAb results, or a patient who is NAb treatment unaffected.
+Treatment unaffected = A post-baseline evaluable patient with a positive result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing. For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="adat04a_cache/html/teal_612fd9fdaa7f21612bc5f66c02928df0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adat04a_cache/html/sessioninfo_adc761d49e159b238cf47d5c515ffcd5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      
+[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adat04a_cache/html/snapshot_dc2d72accbdca4a6deeb4953177e91b7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ADA/adat04a.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ADA/adat03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ADAT03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/ADA/adat04b.html" class="pagination-link">
+        <span class="nav-page-text">ADAT04B</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> ADAT04A</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Baseline Prevalence and Incidence of Treatment Emergent NAbs</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb8-20"><a href="#cb8-20"></a></span>
+<span id="cb8-21"><a href="#cb8-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb8-28"><a href="#cb8-28"></a>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb8-39"><a href="#cb8-39"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>      <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>    )</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-47"><a href="#cb8-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="fu">across</span>(</span>
+<span id="cb8-50"><a href="#cb8-50"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>        <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a>      )),</span>
+<span id="cb8-54"><a href="#cb8-54"></a>      as.logical</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    )</span>
+<span id="cb8-56"><a href="#cb8-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">PADABLPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">PNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>    <span class="at">NNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-64"><a href="#cb8-64"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients for ADA"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patients with a positive ADA sample at baseline"</span>,</span>
+<span id="cb8-66"><a href="#cb8-66"></a>    <span class="at">PNABBLFL =</span> <span class="st">"Patients with a positive NAb sample at baseline"</span>,</span>
+<span id="cb8-67"><a href="#cb8-67"></a>    <span class="at">NNABBLFL =</span> <span class="st">"Patient with no positive NAb samples at baseline"</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>  )</span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a><span class="co"># Post Baseline Treatment Enhanced NAb positive Pts</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-73"><a href="#cb8-73"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-74"><a href="#cb8-74"></a>    ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-75"><a href="#cb8-75"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb8-76"><a href="#cb8-76"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-77"><a href="#cb8-77"></a>      <span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>      <span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>      <span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>      <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>      <span class="st">"Treatment unaffected, Neutralizing Antibody"</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a>    )</span>
+<span id="cb8-83"><a href="#cb8-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU, <span class="sc">-</span>ARRLT, <span class="sc">-</span>NRRLT) <span class="sc">%&gt;%</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-86"><a href="#cb8-86"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-87"><a href="#cb8-87"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-88"><a href="#cb8-88"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-89"><a href="#cb8-89"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-90"><a href="#cb8-90"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    <span class="fu">across</span>(</span>
+<span id="cb8-92"><a href="#cb8-92"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb8-93"><a href="#cb8-93"></a>        <span class="st">"ADA interpreted per sample result"</span>, <span class="st">"NAB interpreted per sample result"</span>,</span>
+<span id="cb8-94"><a href="#cb8-94"></a>        <span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>,</span>
+<span id="cb8-95"><a href="#cb8-95"></a>        <span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb8-96"><a href="#cb8-96"></a>        <span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>,</span>
+<span id="cb8-97"><a href="#cb8-97"></a>        <span class="st">"Treatment unaffected, Neutralizing Antibody"</span></span>
+<span id="cb8-98"><a href="#cb8-98"></a>      )),</span>
+<span id="cb8-99"><a href="#cb8-99"></a>      as.logical</span>
+<span id="cb8-100"><a href="#cb8-100"></a>    )</span>
+<span id="cb8-101"><a href="#cb8-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-102"><a href="#cb8-102"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    <span class="at">ADAPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-105"><a href="#cb8-105"></a>    <span class="at">TENABPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment Emergent - Positive, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment Emergent - Positive, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-106"><a href="#cb8-106"></a>    <span class="at">TINPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment induced ADA, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment induced ADA, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-107"><a href="#cb8-107"></a>    <span class="at">TENPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment enhanced ADA, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment enhanced ADA, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-108"><a href="#cb8-108"></a>    <span class="at">NABNFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-109"><a href="#cb8-109"></a>    <span class="at">TUNPBFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"Treatment unaffected, Neutralizing Antibody"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">Treatment unaffected, Neutralizing Antibody</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb8-110"><a href="#cb8-110"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-111"><a href="#cb8-111"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-112"><a href="#cb8-112"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients for ADA"</span>,</span>
+<span id="cb8-113"><a href="#cb8-113"></a>    <span class="at">ADAPFL =</span> <span class="st">"Patients positive for ADA"</span>,</span>
+<span id="cb8-114"><a href="#cb8-114"></a>    <span class="at">TENABPFL =</span> <span class="st">"Patients positive for Treatment Emergent NAb"</span>,</span>
+<span id="cb8-115"><a href="#cb8-115"></a>    <span class="at">TINPBFL =</span> <span class="st">"Treatment-induced NAb"</span>,</span>
+<span id="cb8-116"><a href="#cb8-116"></a>    <span class="at">TENPBFL =</span> <span class="st">"Treatment-enhanced NAb"</span>,</span>
+<span id="cb8-117"><a href="#cb8-117"></a>    <span class="at">NABNFL =</span> <span class="st">"Patients negative for NAb"</span>,</span>
+<span id="cb8-118"><a href="#cb8-118"></a>    <span class="at">TUNPBFL =</span> <span class="st">"Treatment unaffected"</span></span>
+<span id="cb8-119"><a href="#cb8-119"></a>  )</span>
+<span id="cb8-120"><a href="#cb8-120"></a><span class="in">```</span></span>
+<span id="cb8-121"><a href="#cb8-121"></a></span>
+<span id="cb8-122"><a href="#cb8-122"></a><span class="fu">## Summary of Treatment Emergent NAbs</span></span>
+<span id="cb8-123"><a href="#cb8-123"></a></span>
+<span id="cb8-124"><a href="#cb8-124"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-125"><a href="#cb8-125"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb8-126"><a href="#cb8-126"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-127"><a href="#cb8-127"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-128"><a href="#cb8-128"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-129"><a href="#cb8-129"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-130"><a href="#cb8-130"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-131"><a href="#cb8-131"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-132"><a href="#cb8-132"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-133"><a href="#cb8-133"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADABLPFL"</span>, <span class="st">"PADABLPFL"</span>),</span>
+<span id="cb8-134"><a href="#cb8-134"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span>,</span>
+<span id="cb8-135"><a href="#cb8-135"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-136"><a href="#cb8-136"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of NAbs"</span>,</span>
+<span id="cb8-137"><a href="#cb8-137"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-138"><a href="#cb8-138"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-139"><a href="#cb8-139"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-140"><a href="#cb8-140"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-141"><a href="#cb8-141"></a>    <span class="at">flag_variables =</span> <span class="st">"PNABBLFL"</span>,</span>
+<span id="cb8-142"><a href="#cb8-142"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb8-143"><a href="#cb8-143"></a>    <span class="at">.indent_mods =</span> 1L</span>
+<span id="cb8-144"><a href="#cb8-144"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-145"><a href="#cb8-145"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-146"><a href="#cb8-146"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-147"><a href="#cb8-147"></a>    <span class="at">flag_variables =</span> <span class="st">"NNABBLFL"</span>,</span>
+<span id="cb8-148"><a href="#cb8-148"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-149"><a href="#cb8-149"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span>,</span>
+<span id="cb8-150"><a href="#cb8-150"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-151"><a href="#cb8-151"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-152"><a href="#cb8-152"></a>  )</span>
+<span id="cb8-153"><a href="#cb8-153"></a></span>
+<span id="cb8-154"><a href="#cb8-154"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb8-155"><a href="#cb8-155"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-156"><a href="#cb8-156"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-157"><a href="#cb8-157"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-158"><a href="#cb8-158"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-159"><a href="#cb8-159"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-160"><a href="#cb8-160"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-161"><a href="#cb8-161"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-162"><a href="#cb8-162"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADPBLPFL"</span>, <span class="st">"ADAPFL"</span>),</span>
+<span id="cb8-163"><a href="#cb8-163"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-164"><a href="#cb8-164"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of Treatment Emergent NAbs"</span>,</span>
+<span id="cb8-165"><a href="#cb8-165"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-166"><a href="#cb8-166"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb8-167"><a href="#cb8-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-168"><a href="#cb8-168"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-169"><a href="#cb8-169"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-170"><a href="#cb8-170"></a>    <span class="at">flag_variables =</span> <span class="st">"TENABPFL"</span>,</span>
+<span id="cb8-171"><a href="#cb8-171"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb8-172"><a href="#cb8-172"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-173"><a href="#cb8-173"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-174"><a href="#cb8-174"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-175"><a href="#cb8-175"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-176"><a href="#cb8-176"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-177"><a href="#cb8-177"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"TINPBFL"</span>, <span class="st">"TENPBFL"</span>),</span>
+<span id="cb8-178"><a href="#cb8-178"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-179"><a href="#cb8-179"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb8-180"><a href="#cb8-180"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-181"><a href="#cb8-181"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-182"><a href="#cb8-182"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-183"><a href="#cb8-183"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-184"><a href="#cb8-184"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-185"><a href="#cb8-185"></a>    <span class="at">flag_variables =</span> <span class="st">"NABNFL"</span>,</span>
+<span id="cb8-186"><a href="#cb8-186"></a>    <span class="at">table_names =</span> <span class="st">"tb4"</span>,</span>
+<span id="cb8-187"><a href="#cb8-187"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-188"><a href="#cb8-188"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-189"><a href="#cb8-189"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-190"><a href="#cb8-190"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-191"><a href="#cb8-191"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-192"><a href="#cb8-192"></a>    <span class="at">flag_variables =</span> <span class="st">"TUNPBFL"</span>,</span>
+<span id="cb8-193"><a href="#cb8-193"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-194"><a href="#cb8-194"></a>    <span class="at">table_names =</span> <span class="st">"tb5"</span>,</span>
+<span id="cb8-195"><a href="#cb8-195"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-196"><a href="#cb8-196"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-197"><a href="#cb8-197"></a>  )</span>
+<span id="cb8-198"><a href="#cb8-198"></a></span>
+<span id="cb8-199"><a href="#cb8-199"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-200"><a href="#cb8-200"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-201"><a href="#cb8-201"></a></span>
+<span id="cb8-202"><a href="#cb8-202"></a><span class="co"># Combine tables</span></span>
+<span id="cb8-203"><a href="#cb8-203"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb8-204"><a href="#cb8-204"></a></span>
+<span id="cb8-205"><a href="#cb8-205"></a><span class="co"># Change the column order</span></span>
+<span id="cb8-206"><a href="#cb8-206"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-207"><a href="#cb8-207"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-208"><a href="#cb8-208"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-209"><a href="#cb8-209"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb8-210"><a href="#cb8-210"></a></span>
+<span id="cb8-211"><a href="#cb8-211"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-212"><a href="#cb8-212"></a>  <span class="st">"Baseline Prevalence and Incidence of Treatment Emergent NAbs"</span></span>
+<span id="cb8-213"><a href="#cb8-213"></a>)</span>
+<span id="cb8-214"><a href="#cb8-214"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb8-215"><a href="#cb8-215"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-216"><a href="#cb8-216"></a>  <span class="st">"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s)</span></span>
+<span id="cb8-217"><a href="#cb8-217"></a><span class="st">  Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s)</span></span>
+<span id="cb8-218"><a href="#cb8-218"></a><span class="st">  Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample</span></span>
+<span id="cb8-219"><a href="#cb8-219"></a><span class="st">  Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample</span></span>
+<span id="cb8-220"><a href="#cb8-220"></a><span class="st">  Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.</span></span>
+<span id="cb8-221"><a href="#cb8-221"></a><span class="st">Number of patients positive for Treatment Emergent NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have treatment-induced NAb or treatment-enhanced NAb during the study period.</span></span>
+<span id="cb8-222"><a href="#cb8-222"></a><span class="st">Treatment-induced = a patient with negative or missing baseline result(s) and at least one positive post-baseline result. Treatment-enhanced = a patient with positive result at baseline who has one or more post-baseline titer results that are at least 0.60 t.u. greater than the baseline titer result.</span></span>
+<span id="cb8-223"><a href="#cb8-223"></a><span class="st">Number of patients negative for Treatment Emergent NAb = number of post-baseline evaluable patients with negative or missing baseline NAb result(s) and all negative post-baseline NAb results, or a patient who is NAb treatment unaffected.</span></span>
+<span id="cb8-224"><a href="#cb8-224"></a><span class="st">Treatment unaffected = A post-baseline evaluable patient with a positive result at baseline and (a) where all post-baseline titer results are less than 0.60 t.u. greater than the baseline titer result, OR (b) where all post-baseline results are negative or missing. For any positive sample with titer result less than the minimum reportable titer or any positive sample where a titer cannot be obtained, titer value is imputed as equal to the minimum reportable titer."</span></span>
+<span id="cb8-225"><a href="#cb8-225"></a>)</span>
+<span id="cb8-226"><a href="#cb8-226"></a>result</span>
+<span id="cb8-227"><a href="#cb8-227"></a><span class="in">```</span></span>
+<span id="cb8-228"><a href="#cb8-228"></a></span>
+<span id="cb8-229"><a href="#cb8-229"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-230"><a href="#cb8-230"></a></span>
+<span id="cb8-231"><a href="#cb8-231"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-232"><a href="#cb8-232"></a></span>
+<span id="cb8-233"><a href="#cb8-233"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-234"><a href="#cb8-234"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-235"><a href="#cb8-235"></a></span>
+<span id="cb8-236"><a href="#cb8-236"></a><span class="co"># In progress</span></span>
+<span id="cb8-237"><a href="#cb8-237"></a><span class="in">```</span></span>
+<span id="cb8-238"><a href="#cb8-238"></a></span>
+<span id="cb8-239"><a href="#cb8-239"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-240"><a href="#cb8-240"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/ADA/adat04b.html b/stable/tables/ADA/adat04b.html
new file mode 100644
index 0000000000..4200a3132f
--- /dev/null
+++ b/stable/tables/ADA/adat04b.html
@@ -0,0 +1,2388 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
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+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ADAT04B</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Baseline Prevalence and Incidence of NAbs</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="adat04b_cache/html/setup_e32ac0c9efa80f3df4ad7b4e42d5463f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb1-13"><a href="#cb1-13"></a>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>    )</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="fu">across</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>        <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>      )),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      as.logical</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    )</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">PADABLPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">PNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">NNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients for ADA"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patients with a positive ADA sample at baseline"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>    <span class="at">PNABBLFL =</span> <span class="st">"Patients with a positive NAb sample at baseline"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">NNABBLFL =</span> <span class="st">"Patients with no positive NAb sample at baseline"</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  )</span>
+<span id="cb1-54"><a href="#cb1-54"></a></span>
+<span id="cb1-55"><a href="#cb1-55"></a><span class="co"># Post-Baseline Evaluable Pts</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a>adab_pb_ada <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">filter</span>(ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-58"><a href="#cb1-58"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, ADPBLPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-59"><a href="#cb1-59"></a>  <span class="fu">mutate</span>(<span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb1-61"><a href="#cb1-61"></a></span>
+<span id="cb1-62"><a href="#cb1-62"></a><span class="co"># Post-Baseline ADA Positive Pts</span></span>
+<span id="cb1-63"><a href="#cb1-63"></a>adab_pb_adap <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    PARAM <span class="sc">==</span> <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb1-67"><a href="#cb1-67"></a>    AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span></span>
+<span id="cb1-68"><a href="#cb1-68"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>  <span class="fu">mutate</span>(<span class="at">ADAPFL =</span> AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-70"><a href="#cb1-70"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, ADAPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-71"><a href="#cb1-71"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb1-72"><a href="#cb1-72"></a></span>
+<span id="cb1-73"><a href="#cb1-73"></a><span class="co"># Post-Baseline NAb Positive Pts</span></span>
+<span id="cb1-74"><a href="#cb1-74"></a>adab_pb_nabp <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-75"><a href="#cb1-75"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-76"><a href="#cb1-76"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-77"><a href="#cb1-77"></a>    PARAM <span class="sc">==</span> <span class="st">"NAb interpreted per sample result"</span>,</span>
+<span id="cb1-78"><a href="#cb1-78"></a>    AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span></span>
+<span id="cb1-79"><a href="#cb1-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-80"><a href="#cb1-80"></a>  <span class="fu">mutate</span>(<span class="at">NABPFL =</span> AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-81"><a href="#cb1-81"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, NABPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-82"><a href="#cb1-82"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb1-83"><a href="#cb1-83"></a></span>
+<span id="cb1-84"><a href="#cb1-84"></a><span class="co"># Post-Baseline NAb Negative Pts</span></span>
+<span id="cb1-85"><a href="#cb1-85"></a>adab_pb_nabn <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb1-86"><a href="#cb1-86"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-87"><a href="#cb1-87"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-88"><a href="#cb1-88"></a>    PARAM <span class="sc">==</span> <span class="st">"NAb interpreted per sample result"</span>,</span>
+<span id="cb1-89"><a href="#cb1-89"></a>    AVALC <span class="sc">==</span> <span class="st">"NEGATIVE"</span></span>
+<span id="cb1-90"><a href="#cb1-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-91"><a href="#cb1-91"></a>  <span class="fu">rename</span>(<span class="at">NABNFL =</span> AVALC) <span class="sc">%&gt;%</span></span>
+<span id="cb1-92"><a href="#cb1-92"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, NABNFL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-93"><a href="#cb1-93"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb1-94"><a href="#cb1-94"></a></span>
+<span id="cb1-95"><a href="#cb1-95"></a>mergecol <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ARM"</span>, <span class="st">"ACTARM"</span>)</span>
+<span id="cb1-96"><a href="#cb1-96"></a></span>
+<span id="cb1-97"><a href="#cb1-97"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">left_join</span>(adab_pb_ada, adab_pb_adap, <span class="at">by =</span> mergecol) <span class="sc">%&gt;%</span></span>
+<span id="cb1-98"><a href="#cb1-98"></a>  <span class="fu">left_join</span>(adab_pb_nabp, <span class="at">by =</span> mergecol) <span class="sc">%&gt;%</span></span>
+<span id="cb1-99"><a href="#cb1-99"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-100"><a href="#cb1-100"></a>    <span class="at">NABNFL =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(NABPFL), <span class="st">"TRUE"</span>, <span class="st">"FALSE"</span>),</span>
+<span id="cb1-101"><a href="#cb1-101"></a>    <span class="at">NABNFL =</span> NABNFL <span class="sc">==</span> <span class="st">"TRUE"</span></span>
+<span id="cb1-102"><a href="#cb1-102"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-103"><a href="#cb1-103"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-104"><a href="#cb1-104"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients for ADA"</span>,</span>
+<span id="cb1-105"><a href="#cb1-105"></a>    <span class="at">ADAPFL =</span> <span class="st">"Patients positive for ADA"</span>,</span>
+<span id="cb1-106"><a href="#cb1-106"></a>    <span class="at">NABPFL =</span> <span class="st">"Patients positive for NAb"</span>,</span>
+<span id="cb1-107"><a href="#cb1-107"></a>    <span class="at">NABNFL =</span> <span class="st">"Patients negative for NAb"</span></span>
+<span id="cb1-108"><a href="#cb1-108"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="adat04b_cache/html/variant1_3c58944a246573de7925d918b9ecae29">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADABLPFL"</span>, <span class="st">"PADABLPFL"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of NAbs"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">flag_variables =</span> <span class="st">"PNABBLFL"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">flag_variables =</span> <span class="st">"NNABBLFL"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  )</span>
+<span id="cb2-30"><a href="#cb2-30"></a></span>
+<span id="cb2-31"><a href="#cb2-31"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADPBLPFL"</span>, <span class="st">"ADAPFL"</span>),</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of NAbs"</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-45"><a href="#cb2-45"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-46"><a href="#cb2-46"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-47"><a href="#cb2-47"></a>    <span class="at">flag_variables =</span> <span class="st">"NABPFL"</span>,</span>
+<span id="cb2-48"><a href="#cb2-48"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-50"><a href="#cb2-50"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-51"><a href="#cb2-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-52"><a href="#cb2-52"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-53"><a href="#cb2-53"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-54"><a href="#cb2-54"></a>    <span class="at">flag_variables =</span> <span class="st">"NABNFL"</span>,</span>
+<span id="cb2-55"><a href="#cb2-55"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-56"><a href="#cb2-56"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb2-58"><a href="#cb2-58"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-59"><a href="#cb2-59"></a>  )</span>
+<span id="cb2-60"><a href="#cb2-60"></a></span>
+<span id="cb2-61"><a href="#cb2-61"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-62"><a href="#cb2-62"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-63"><a href="#cb2-63"></a></span>
+<span id="cb2-64"><a href="#cb2-64"></a><span class="co"># Combine tables.</span></span>
+<span id="cb2-65"><a href="#cb2-65"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb2-66"><a href="#cb2-66"></a></span>
+<span id="cb2-67"><a href="#cb2-67"></a><span class="co"># Change the column order.</span></span>
+<span id="cb2-68"><a href="#cb2-68"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-69"><a href="#cb2-69"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-70"><a href="#cb2-70"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb2-71"><a href="#cb2-71"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb2-72"><a href="#cb2-72"></a></span>
+<span id="cb2-73"><a href="#cb2-73"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-74"><a href="#cb2-74"></a>  <span class="st">"Baseline Prevalence and Incidence of Neutralizing Antibodies (NAbs)"</span></span>
+<span id="cb2-75"><a href="#cb2-75"></a>)</span>
+<span id="cb2-76"><a href="#cb2-76"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb2-77"><a href="#cb2-77"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-78"><a href="#cb2-78"></a>  <span class="st">"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s) Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s) Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.</span></span>
+<span id="cb2-79"><a href="#cb2-79"></a><span class="st">Number of patients positive for NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have at least one positive post-baseline NAb result during the study period. Number of patients negative for NAb = number of post-baseline evaluable patients with all negative post-baseline NAb results."</span></span>
+<span id="cb2-80"><a href="#cb2-80"></a>)</span>
+<span id="cb2-81"><a href="#cb2-81"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Prevalence and Incidence of Neutralizing Antibodies (NAbs)
+Protocol: A: Drug X Antibody
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                    A: Drug X   C: Combination   &lt;Missing&gt;   B: Placebo   All Drug X
+                                                     (N=134)       (N=132)         (N=0)      (N=134)      (N=266)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Baseline Prevalence of NAbs                                                                                         
+  Baseline evaluable patients for ADA                  134           132             0           0           266    
+  Patients with a positive ADA sample at baseline      63             64             0           0           127    
+Patients with a positive NAb sample at baseline         0             0             NA           NA           0     
+Patients with no positive NAb sample at baseline        0             0              0           0            0     
+Incidence of NAbs                                                                                                   
+  Post-baseline evaluable patients for ADA             134           132             0           0           266    
+  Patients positive for ADA                            66             59             0           0           125    
+Patients positive for NAb                               0             0             NA           NA           0     
+Patients negative for NAb                              134           132             0           0           266    
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s) Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s) Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.
+Number of patients positive for NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have at least one positive post-baseline NAb result during the study period. Number of patients negative for NAb = number of post-baseline evaluable patients with all negative post-baseline NAb results.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="adat04b_cache/html/teal_43f010b52dd81fd4afe8397d78d14063">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="adat04b_cache/html/sessioninfo_5e9a01a29fdd78b35637e75b3f45b6db">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tibble_3.2.1     scda_0.1.6       dplyr_1.1.3      tern_0.9.0      
+[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         withr_2.5.0       Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="adat04b_cache/html/snapshot_799d9ba2dcfb4aed3a59d850eef062e1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ADA/adat04b.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ADA/adat04a.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ADAT04A</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet01.html" class="pagination-link">
+        <span class="nav-page-text">AET01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> ADAT04B</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Baseline Prevalence and Incidence of NAbs</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(tibble)</span>
+<span id="cb8-20"><a href="#cb8-20"></a></span>
+<span id="cb8-21"><a href="#cb8-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>adab <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adab"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a>combodf <span class="ot">&lt;-</span> <span class="fu">tribble</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="sc">~</span>valname, <span class="sc">~</span>label, <span class="sc">~</span>levelcombo, <span class="sc">~</span>exargs,</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="st">"all_X"</span>, <span class="st">"All Drug X"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>(),</span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="st">"all_pt"</span>, <span class="st">"All Patients"</span>, <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>, <span class="st">"C: Combination"</span>), <span class="fu">list</span>()</span>
+<span id="cb8-28"><a href="#cb8-28"></a>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a><span class="co"># Baseline Pts</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>adab_b <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    PARAM <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb8-39"><a href="#cb8-39"></a>      <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>      <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>    )</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">select</span>(<span class="sc">-</span>PARAMCD, <span class="sc">-</span>AVALC, <span class="sc">-</span>AVALU) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">names_from =</span> PARAM,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb8-47"><a href="#cb8-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="fu">across</span>(</span>
+<span id="cb8-50"><a href="#cb8-50"></a>      <span class="fu">any_of</span>(<span class="fu">c</span>(</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>        <span class="st">"NAB interpreted per sample result"</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a>      )),</span>
+<span id="cb8-54"><a href="#cb8-54"></a>      as.logical</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    )</span>
+<span id="cb8-56"><a href="#cb8-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">ADABLPFL =</span> ADABLPFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">PADABLPFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"ADA interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">ADA interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">PNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"TRUE"</span> <span class="cf">else</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>    <span class="at">NNABBLFL =</span> <span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"NAB interpreted per sample result"</span>, <span class="at">where =</span> .)) <span class="st">`</span><span class="at">NAB interpreted per sample result</span><span class="st">`</span> <span class="sc">==</span> <span class="st">"FALSE"</span> <span class="cf">else</span> <span class="cn">FALSE</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-64"><a href="#cb8-64"></a>    <span class="at">ADABLPFL =</span> <span class="st">"Baseline evaluable patients for ADA"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>    <span class="at">PADABLPFL =</span> <span class="st">"Patients with a positive ADA sample at baseline"</span>,</span>
+<span id="cb8-66"><a href="#cb8-66"></a>    <span class="at">PNABBLFL =</span> <span class="st">"Patients with a positive NAb sample at baseline"</span>,</span>
+<span id="cb8-67"><a href="#cb8-67"></a>    <span class="at">NNABBLFL =</span> <span class="st">"Patients with no positive NAb sample at baseline"</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>  )</span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a><span class="co"># Post-Baseline Evaluable Pts</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a>adab_pb_ada <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="fu">filter</span>(ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, ADPBLPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="fu">mutate</span>(<span class="at">ADPBLPFL =</span> ADPBLPFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="co"># Post-Baseline ADA Positive Pts</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a>adab_pb_adap <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    PARAM <span class="sc">==</span> <span class="st">"ADA interpreted per sample result"</span>,</span>
+<span id="cb8-82"><a href="#cb8-82"></a>    AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="fu">mutate</span>(<span class="at">ADAPFL =</span> AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, ADAPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb8-86"><a href="#cb8-86"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb8-87"><a href="#cb8-87"></a></span>
+<span id="cb8-88"><a href="#cb8-88"></a><span class="co"># Post-Baseline NAb Positive Pts</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>adab_pb_nabp <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-90"><a href="#cb8-90"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-92"><a href="#cb8-92"></a>    PARAM <span class="sc">==</span> <span class="st">"NAb interpreted per sample result"</span>,</span>
+<span id="cb8-93"><a href="#cb8-93"></a>    AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span></span>
+<span id="cb8-94"><a href="#cb8-94"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-95"><a href="#cb8-95"></a>  <span class="fu">mutate</span>(<span class="at">NABPFL =</span> AVALC <span class="sc">==</span> <span class="st">"POSITIVE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, NABPFL) <span class="sc">%&gt;%</span></span>
+<span id="cb8-97"><a href="#cb8-97"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb8-98"><a href="#cb8-98"></a></span>
+<span id="cb8-99"><a href="#cb8-99"></a><span class="co"># Post-Baseline NAb Negative Pts</span></span>
+<span id="cb8-100"><a href="#cb8-100"></a>adab_pb_nabn <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adab) <span class="sc">%&gt;%</span></span>
+<span id="cb8-101"><a href="#cb8-101"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-102"><a href="#cb8-102"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    PARAM <span class="sc">==</span> <span class="st">"NAb interpreted per sample result"</span>,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    AVALC <span class="sc">==</span> <span class="st">"NEGATIVE"</span></span>
+<span id="cb8-105"><a href="#cb8-105"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-106"><a href="#cb8-106"></a>  <span class="fu">rename</span>(<span class="at">NABNFL =</span> AVALC) <span class="sc">%&gt;%</span></span>
+<span id="cb8-107"><a href="#cb8-107"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, ACTARM, NABNFL) <span class="sc">%&gt;%</span></span>
+<span id="cb8-108"><a href="#cb8-108"></a>  <span class="fu">distinct</span>()</span>
+<span id="cb8-109"><a href="#cb8-109"></a></span>
+<span id="cb8-110"><a href="#cb8-110"></a>mergecol <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ARM"</span>, <span class="st">"ACTARM"</span>)</span>
+<span id="cb8-111"><a href="#cb8-111"></a></span>
+<span id="cb8-112"><a href="#cb8-112"></a>adab_pb <span class="ot">&lt;-</span> <span class="fu">left_join</span>(adab_pb_ada, adab_pb_adap, <span class="at">by =</span> mergecol) <span class="sc">%&gt;%</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a>  <span class="fu">left_join</span>(adab_pb_nabp, <span class="at">by =</span> mergecol) <span class="sc">%&gt;%</span></span>
+<span id="cb8-114"><a href="#cb8-114"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-115"><a href="#cb8-115"></a>    <span class="at">NABNFL =</span> <span class="fu">ifelse</span>(<span class="fu">is.na</span>(NABPFL), <span class="st">"TRUE"</span>, <span class="st">"FALSE"</span>),</span>
+<span id="cb8-116"><a href="#cb8-116"></a>    <span class="at">NABNFL =</span> NABNFL <span class="sc">==</span> <span class="st">"TRUE"</span></span>
+<span id="cb8-117"><a href="#cb8-117"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-118"><a href="#cb8-118"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-119"><a href="#cb8-119"></a>    <span class="at">ADPBLPFL =</span> <span class="st">"Post-baseline evaluable patients for ADA"</span>,</span>
+<span id="cb8-120"><a href="#cb8-120"></a>    <span class="at">ADAPFL =</span> <span class="st">"Patients positive for ADA"</span>,</span>
+<span id="cb8-121"><a href="#cb8-121"></a>    <span class="at">NABPFL =</span> <span class="st">"Patients positive for NAb"</span>,</span>
+<span id="cb8-122"><a href="#cb8-122"></a>    <span class="at">NABNFL =</span> <span class="st">"Patients negative for NAb"</span></span>
+<span id="cb8-123"><a href="#cb8-123"></a>  )</span>
+<span id="cb8-124"><a href="#cb8-124"></a><span class="in">```</span></span>
+<span id="cb8-125"><a href="#cb8-125"></a></span>
+<span id="cb8-126"><a href="#cb8-126"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-127"><a href="#cb8-127"></a></span>
+<span id="cb8-128"><a href="#cb8-128"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-129"><a href="#cb8-129"></a><span class="co"># Layout for Baseline Prevalence of NAbs</span></span>
+<span id="cb8-130"><a href="#cb8-130"></a>lyt_bl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-131"><a href="#cb8-131"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-132"><a href="#cb8-132"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-133"><a href="#cb8-133"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-134"><a href="#cb8-134"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-135"><a href="#cb8-135"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-136"><a href="#cb8-136"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-137"><a href="#cb8-137"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADABLPFL"</span>, <span class="st">"PADABLPFL"</span>),</span>
+<span id="cb8-138"><a href="#cb8-138"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-139"><a href="#cb8-139"></a>    <span class="at">var_labels =</span> <span class="st">"Baseline Prevalence of NAbs"</span>,</span>
+<span id="cb8-140"><a href="#cb8-140"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-141"><a href="#cb8-141"></a>    <span class="at">table_names =</span> <span class="st">"t1"</span></span>
+<span id="cb8-142"><a href="#cb8-142"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-143"><a href="#cb8-143"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-144"><a href="#cb8-144"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-145"><a href="#cb8-145"></a>    <span class="at">flag_variables =</span> <span class="st">"PNABBLFL"</span>,</span>
+<span id="cb8-146"><a href="#cb8-146"></a>    <span class="at">table_names =</span> <span class="st">"t2"</span>,</span>
+<span id="cb8-147"><a href="#cb8-147"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-148"><a href="#cb8-148"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-149"><a href="#cb8-149"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-150"><a href="#cb8-150"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-151"><a href="#cb8-151"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-152"><a href="#cb8-152"></a>    <span class="at">flag_variables =</span> <span class="st">"NNABBLFL"</span>,</span>
+<span id="cb8-153"><a href="#cb8-153"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-154"><a href="#cb8-154"></a>    <span class="at">table_names =</span> <span class="st">"t3"</span>,</span>
+<span id="cb8-155"><a href="#cb8-155"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-156"><a href="#cb8-156"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-157"><a href="#cb8-157"></a>  )</span>
+<span id="cb8-158"><a href="#cb8-158"></a></span>
+<span id="cb8-159"><a href="#cb8-159"></a><span class="co"># Layout for incidence of NAbs</span></span>
+<span id="cb8-160"><a href="#cb8-160"></a>lyt_pb <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-161"><a href="#cb8-161"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb8-162"><a href="#cb8-162"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb8-163"><a href="#cb8-163"></a>    <span class="at">split_fun =</span> <span class="fu">add_combo_levels</span>(combodf)</span>
+<span id="cb8-164"><a href="#cb8-164"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-165"><a href="#cb8-165"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-166"><a href="#cb8-166"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-167"><a href="#cb8-167"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(<span class="st">"ADPBLPFL"</span>, <span class="st">"ADAPFL"</span>),</span>
+<span id="cb8-168"><a href="#cb8-168"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-169"><a href="#cb8-169"></a>    <span class="at">var_labels =</span> <span class="st">"Incidence of NAbs"</span>,</span>
+<span id="cb8-170"><a href="#cb8-170"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-171"><a href="#cb8-171"></a>    <span class="at">table_names =</span> <span class="st">"tb1"</span></span>
+<span id="cb8-172"><a href="#cb8-172"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-173"><a href="#cb8-173"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-174"><a href="#cb8-174"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-175"><a href="#cb8-175"></a>    <span class="at">flag_variables =</span> <span class="st">"NABPFL"</span>,</span>
+<span id="cb8-176"><a href="#cb8-176"></a>    <span class="at">table_names =</span> <span class="st">"tb2"</span>,</span>
+<span id="cb8-177"><a href="#cb8-177"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-178"><a href="#cb8-178"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-179"><a href="#cb8-179"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-180"><a href="#cb8-180"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-181"><a href="#cb8-181"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-182"><a href="#cb8-182"></a>    <span class="at">flag_variables =</span> <span class="st">"NABNFL"</span>,</span>
+<span id="cb8-183"><a href="#cb8-183"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-184"><a href="#cb8-184"></a>    <span class="at">table_names =</span> <span class="st">"tb3"</span>,</span>
+<span id="cb8-185"><a href="#cb8-185"></a>    <span class="at">.indent_mods =</span> 1L,</span>
+<span id="cb8-186"><a href="#cb8-186"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-187"><a href="#cb8-187"></a>  )</span>
+<span id="cb8-188"><a href="#cb8-188"></a></span>
+<span id="cb8-189"><a href="#cb8-189"></a>result_1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_bl, <span class="at">df =</span> adab_b, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-190"><a href="#cb8-190"></a>result_2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_pb, <span class="at">df =</span> adab_pb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-191"><a href="#cb8-191"></a></span>
+<span id="cb8-192"><a href="#cb8-192"></a><span class="co"># Combine tables.</span></span>
+<span id="cb8-193"><a href="#cb8-193"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result_1, result_2)</span>
+<span id="cb8-194"><a href="#cb8-194"></a></span>
+<span id="cb8-195"><a href="#cb8-195"></a><span class="co"># Change the column order.</span></span>
+<span id="cb8-196"><a href="#cb8-196"></a>result <span class="ot">&lt;-</span> <span class="fu">cbind_rtables</span>(result[, <span class="dv">1</span>], result[, <span class="dv">3</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-197"><a href="#cb8-197"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">4</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-198"><a href="#cb8-198"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">2</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb8-199"><a href="#cb8-199"></a>  <span class="fu">cbind_rtables</span>(result[, <span class="dv">5</span>])</span>
+<span id="cb8-200"><a href="#cb8-200"></a></span>
+<span id="cb8-201"><a href="#cb8-201"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-202"><a href="#cb8-202"></a>  <span class="st">"Baseline Prevalence and Incidence of Neutralizing Antibodies (NAbs)"</span></span>
+<span id="cb8-203"><a href="#cb8-203"></a>)</span>
+<span id="cb8-204"><a href="#cb8-204"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Protocol:"</span>, <span class="fu">unique</span>(adab<span class="sc">$</span>PARCAT1)[<span class="dv">1</span>])</span>
+<span id="cb8-205"><a href="#cb8-205"></a><span class="fu">main_footer</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-206"><a href="#cb8-206"></a>  <span class="st">"NAb = Neutralizing Antibodies ADA = Anti-Drug Antibodies (is also referred to as ATA, or Anti-Therapeutic Antibodies) Baseline evaluable patient for ADA = a patient with an ADA assay result from a baseline sample(s) Baseline evaluable patient for NAb = a patient with a NAb assay result from a baseline sample(s) Post-baseline evaluable patient for ADA = a patient with an ADA assay result from at least one post-baseline sample Post-baseline evaluable patient for NAb = a patient with a NAb assay result from at least one post-baseline sample Number of patients positive for ADA = the number of post-baseline evaluable patients for ADA determined to have Treatment Emergent ADA during the study period.</span></span>
+<span id="cb8-207"><a href="#cb8-207"></a><span class="st">Number of patients positive for NAb = the number (and percentage) of post-baseline evaluable patients for ADA determined to have at least one positive post-baseline NAb result during the study period. Number of patients negative for NAb = number of post-baseline evaluable patients with all negative post-baseline NAb results."</span></span>
+<span id="cb8-208"><a href="#cb8-208"></a>)</span>
+<span id="cb8-209"><a href="#cb8-209"></a>result</span>
+<span id="cb8-210"><a href="#cb8-210"></a><span class="in">```</span></span>
+<span id="cb8-211"><a href="#cb8-211"></a></span>
+<span id="cb8-212"><a href="#cb8-212"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-213"><a href="#cb8-213"></a></span>
+<span id="cb8-214"><a href="#cb8-214"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-215"><a href="#cb8-215"></a></span>
+<span id="cb8-216"><a href="#cb8-216"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-217"><a href="#cb8-217"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-218"><a href="#cb8-218"></a></span>
+<span id="cb8-219"><a href="#cb8-219"></a><span class="co"># In progress</span></span>
+<span id="cb8-220"><a href="#cb8-220"></a><span class="in">```</span></span>
+<span id="cb8-221"><a href="#cb8-221"></a></span>
+<span id="cb8-222"><a href="#cb8-222"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-223"><a href="#cb8-223"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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new file mode 100644
index 0000000000..3c43ac8b7a
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+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
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+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Tables</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EGT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ECG Results and Change from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="egt01_cache/html/setup_08e0d87f6cd7dcefd44fecacf7e261ba">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="co"># Data should be filtered for the studied Parameter (`PARAM`) and the</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="co"># Analysis Visit (`AVISIT`). According to the GDSR template, the values for</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># the `AVISIT` reported in the EGT01 standard may be:</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># 'POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST'.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Heart Rate"</span>, <span class="st">"QT Duration"</span>, <span class="st">"RR Duration"</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="egt01_cache/html/variant1_11d94e98908d18bb411e4a619c09278b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  } <span class="cf">else</span> {</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  }</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  )</span>
+<span id="cb2-27"><a href="#cb2-27"></a>}</span>
+<span id="cb2-28"><a href="#cb2-28"></a></span>
+<span id="cb2-29"><a href="#cb2-29"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb2-38"><a href="#cb2-38"></a></span>
+<span id="cb2-39"><a href="#cb2-39"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-40"><a href="#cb2-40"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                        A: Drug X                              B: Placebo                            C: Combination            
+  Analysis Visit                         Change from                             Change from                             Change from    
+                    Value at Visit         Baseline         Value at Visit         Baseline         Value at Visit         Baseline     
+                       (N=134)             (N=134)             (N=134)             (N=134)             (N=132)             (N=132)      
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Heart Rate                                                                                                                              
+  BASELINE                                                                                                                              
+    n                    134                                     134                                     132                            
+    Mean (SD)       71.45 (17.93)                           69.83 (20.72)                           69.34 (20.95)                       
+    Median              72.70                                   73.35                                   71.96                           
+    Min - Max       9.09 - 106.91                           13.49 - 115.52                          11.63 - 115.49                      
+  WEEK 1 DAY 8                                                                                                                          
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       70.19 (20.27)       -1.26 (25.97)       69.43 (20.80)       -0.40 (29.73)       68.65 (18.06)       -0.69 (27.81)   
+    Median              70.70               -2.20               70.46               -0.52               68.57               -0.76       
+    Min - Max       8.53 - 127.50       -50.97 - 89.16      16.85 - 129.14      -68.18 - 88.38      16.87 - 115.60      -68.25 - 67.20  
+  WEEK 2 DAY 15                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       70.32 (19.56)       -1.13 (26.26)       71.11 (20.56)        1.28 (31.35)       69.19 (18.06)       -0.15 (28.61)   
+    Median              70.88               -1.10               72.52               -0.31               69.30               -1.55       
+    Min - Max       17.14 - 116.32      -85.03 - 67.52      9.22 - 120.54       -73.07 - 81.44      29.62 - 120.50      -67.75 - 66.29  
+  WEEK 3 DAY 22                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       68.25 (20.17)       -3.20 (28.66)       68.95 (20.56)       -0.88 (30.14)       70.88 (20.28)        1.54 (27.28)   
+    Median              68.79               -2.17               67.80                1.19               70.12                0.14       
+    Min - Max       13.33 - 131.73      -81.20 - 72.57      23.98 - 130.41     -73.03 - 103.31      20.91 - 116.79      -64.51 - 72.52  
+  WEEK 4 DAY 29                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       70.06 (18.41)       -1.38 (26.59)       71.60 (20.34)        1.77 (30.26)       71.02 (20.59)        1.68 (29.60)   
+    Median              69.33               -4.54               72.21               -0.88               70.52                3.81       
+    Min - Max       22.30 - 116.51      -58.07 - 77.32      17.53 - 129.06      -64.32 - 85.34      10.35 - 117.30     -65.91 - 105.67  
+  WEEK 5 DAY 36                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       66.41 (19.74)       -5.04 (27.11)       71.25 (18.92)        1.42 (27.08)       71.26 (18.56)        1.92 (29.59)   
+    Median              65.40               -6.83               70.86                0.64               73.29                1.74       
+    Min - Max       23.89 - 110.38      -73.26 - 57.24      25.86 - 125.73      -71.15 - 67.37      23.89 - 117.19      -58.23 - 68.86  
+QT Duration                                                                                                                             
+  BASELINE                                                                                                                              
+    n                    134                                     134                                     132                            
+    Mean (SD)      336.83 (117.96)                          351.00 (98.44)                         352.60 (105.11)                      
+    Median              344.41                                  351.48                                  347.96                          
+    Min - Max       86.98 - 665.40                          98.90 - 641.92                         105.68 - 628.14                      
+  WEEK 1 DAY 8                                                                                                                          
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      342.57 (101.09)      5.74 (159.94)      363.95 (102.34)      12.94 (140.73)     359.42 (105.16)      6.83 (147.13)   
+    Median              347.26              -1.78               356.54              13.73               363.84               8.69       
+    Min - Max       91.63 - 591.42     -346.44 - 452.75    114.92 - 656.45     -317.53 - 416.35     51.91 - 611.88     -473.19 - 358.00 
+  WEEK 2 DAY 15                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       353.24 (93.93)      16.41 (162.10)      345.93 (96.78)      -5.08 (152.51)      335.69 (98.61)     -16.91 (138.45)  
+    Median              351.10              16.72               346.83              -9.68               320.96              -22.27      
+    Min - Max      138.01 - 587.30     -414.07 - 389.16    146.42 - 556.07     -440.28 - 364.76    104.91 - 562.34     -326.55 - 325.27 
+  WEEK 3 DAY 22                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      370.12 (101.57)      33.28 (152.78)     343.41 (102.58)      -7.59 (138.80)      346.95 (94.96)      -5.65 (144.65)  
+    Median              378.21              39.59               335.12              -15.89              352.15               9.11       
+    Min - Max      118.14 - 615.18     -391.72 - 520.09     63.37 - 566.51     -311.28 - 293.76    126.09 - 580.81     -412.11 - 410.01 
+  WEEK 4 DAY 29                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       345.77 (95.97)      8.94 (145.65)      354.38 (108.29)      3.37 (142.39)      341.36 (106.75)     -11.24 (145.65)  
+    Median              340.13               5.58               346.70              -17.13              352.30              -11.87      
+    Min - Max      110.12 - 616.58     -393.34 - 456.04     80.82 - 687.69     -439.90 - 364.80     4.95 - 570.61      -480.94 - 330.67 
+  WEEK 5 DAY 36                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)       358.90 (97.69)      22.07 (155.68)      338.65 (99.26)     -12.36 (130.46)      349.30 (95.77)      -3.30 (136.00)  
+    Median              351.96               5.89               344.17               0.40               350.32              12.68       
+    Min - Max       88.38 - 661.12     -353.30 - 539.84     31.25 - 563.90     -338.85 - 352.75    119.02 - 581.83     -311.45 - 295.53 
+RR Duration                                                                                                                             
+  BASELINE                                                                                                                              
+    n                    134                                     134                                     132                            
+    Mean (SD)      1028.42 (286.38)                        1027.48 (324.00)                        1074.62 (277.33)                     
+    Median             1041.86                                 1047.27                                 1080.87                          
+    Min - Max      34.33 - 1783.71                          5.29 - 1877.19                         289.60 - 1617.06                     
+  WEEK 1 DAY 8                                                                                                                          
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      990.15 (318.74)     -38.26 (446.40)     1061.59 (269.14)     34.10 (401.76)     1039.64 (284.39)    -34.98 (406.04)  
+    Median              963.88              -86.50             1061.50              66.91              1014.78              -97.83      
+    Min - Max      110.82 - 2014.56   -1014.82 - 1389.40   276.83 - 1711.99    -942.16 - 993.82    498.21 - 1937.47    -958.61 - 908.90 
+  WEEK 2 DAY 15                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      1013.37 (304.13)    -15.05 (425.81)     1109.40 (318.23)     81.92 (453.11)     1045.21 (277.51)    -29.41 (380.84)  
+    Median             1040.69              40.49              1117.76              69.27              1034.64              -15.33      
+    Min - Max      164.19 - 1677.10   -1216.10 - 1053.15   160.73 - 2048.73   -1127.10 - 1148.61   252.84 - 1722.33    -859.27 - 871.54 
+  WEEK 3 DAY 22                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      1013.99 (304.99)    -14.43 (406.53)     1118.35 (296.53)     90.86 (409.57)     1036.59 (268.52)    -38.03 (421.48)  
+    Median             1027.23              -50.54             1134.60              52.03              1030.72              -60.72      
+    Min - Max      357.04 - 1798.65   -882.94 - 1080.26    97.14 - 1825.43    -887.06 - 1166.15    446.02 - 1713.38    -984.79 - 902.37 
+  WEEK 4 DAY 29                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      1033.31 (313.92)     4.89 (483.15)      1079.76 (298.94)     52.28 (429.25)     1027.55 (295.86)    -47.07 (378.23)  
+    Median             1050.40               5.60              1051.61              69.55              1023.36              -49.52      
+    Min - Max      54.33 - 1979.43    -1345.93 - 1195.41   347.94 - 1762.04   -826.43 - 1191.83    341.62 - 2144.86   -1002.03 - 1048.66
+  WEEK 5 DAY 36                                                                                                                         
+    n                    134                 134                 134                 134                 132                 132        
+    Mean (SD)      1072.33 (282.90)     43.92 (379.05)     1058.45 (271.01)     30.97 (436.03)     1029.04 (271.21)    -45.58 (405.53)  
+    Median             1067.33              55.87              1068.95              33.61              1065.26              -34.40      
+    Min - Max      352.97 - 2000.56   -1028.79 - 1418.57   208.83 - 1794.73   -978.97 - 1365.13    436.28 - 1794.07   -962.18 - 1329.88 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="egt01_cache/html/teal_584f896a6d9a859712d666ef31c0cefb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-9"><a href="#cb4-9"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>      adsl,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>    ),</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>      adeg,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      <span class="at">code =</span> <span class="st">'ADEG &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adeg"))'</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>    ),</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  ),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      <span class="at">label =</span> <span class="st">"ECG Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-28"><a href="#cb4-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>      ),</span>
+<span id="cb4-31"><a href="#cb4-31"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-33"><a href="#cb4-33"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb4-34"><a href="#cb4-34"></a>      ),</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>)</span>
+<span id="cb4-38"><a href="#cb4-38"></a>      ),</span>
+<span id="cb4-39"><a href="#cb4-39"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-41"><a href="#cb4-41"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adeg, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-42"><a href="#cb4-42"></a>        <span class="at">selected =</span> <span class="st">"HR"</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>      ),</span>
+<span id="cb4-44"><a href="#cb4-44"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>    )</span>
+<span id="cb4-46"><a href="#cb4-46"></a>  ),</span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADEG =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb4-48"><a href="#cb4-48"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:11:33.3826 pid:9574 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="egt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egt01_cache/html/sessioninfo_ba8195ab7d61db3c3b9aae66e28c04cb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egt01_cache/html/snapshot_4d78191f69ee533cf8408c527e08d251">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ECG/egt01.lock">Download</a></p>
+</section>
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+          popup.appendChild(citeDiv);
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+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/disposition/pdt02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PDT02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/ECG/egt02.html" class="pagination-link">
+        <span class="nav-page-text">EGT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> EGT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> ECG Results and Change from Baseline by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a><span class="co"># Data should be filtered for the studied Parameter (`PARAM`) and the</span></span>
+<span id="cb10-21"><a href="#cb10-21"></a><span class="co"># Analysis Visit (`AVISIT`). According to the GDSR template, the values for</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a><span class="co"># the `AVISIT` reported in the EGT01 standard may be:</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># 'POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST'.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-26"><a href="#cb10-26"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb10-27"><a href="#cb10-27"></a></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-30"><a href="#cb10-30"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb10-31"><a href="#cb10-31"></a></span>
+<span id="cb10-32"><a href="#cb10-32"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Heart Rate"</span>, <span class="st">"QT Duration"</span>, <span class="st">"RR Duration"</span>))</span>
+<span id="cb10-35"><a href="#cb10-35"></a><span class="in">```</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a></span>
+<span id="cb10-37"><a href="#cb10-37"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="co"># Define the split function</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-42"><a href="#cb10-42"></a></span>
+<span id="cb10-43"><a href="#cb10-43"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb10-44"><a href="#cb10-44"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-49"><a href="#cb10-49"></a>  } <span class="cf">else</span> {</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb10-51"><a href="#cb10-51"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  }</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a></span>
+<span id="cb10-58"><a href="#cb10-58"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb10-64"><a href="#cb10-64"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb10-65"><a href="#cb10-65"></a>  )</span>
+<span id="cb10-66"><a href="#cb10-66"></a>}</span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb10-73"><a href="#cb10-73"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb10-74"><a href="#cb10-74"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb10-75"><a href="#cb10-75"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb10-77"><a href="#cb10-77"></a></span>
+<span id="cb10-78"><a href="#cb10-78"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-79"><a href="#cb10-79"></a>result</span>
+<span id="cb10-80"><a href="#cb10-80"></a><span class="in">```</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a></span>
+<span id="cb10-82"><a href="#cb10-82"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-83"><a href="#cb10-83"></a></span>
+<span id="cb10-84"><a href="#cb10-84"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-85"><a href="#cb10-85"></a></span>
+<span id="cb10-86"><a href="#cb10-86"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a></span>
+<span id="cb10-89"><a href="#cb10-89"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-93"><a href="#cb10-93"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb10-94"><a href="#cb10-94"></a></span>
+<span id="cb10-95"><a href="#cb10-95"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-97"><a href="#cb10-97"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb10-98"><a href="#cb10-98"></a></span>
+<span id="cb10-99"><a href="#cb10-99"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-100"><a href="#cb10-100"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-101"><a href="#cb10-101"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb10-102"><a href="#cb10-102"></a>      adsl,</span>
+<span id="cb10-103"><a href="#cb10-103"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a>    ),</span>
+<span id="cb10-105"><a href="#cb10-105"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>,</span>
+<span id="cb10-106"><a href="#cb10-106"></a>      adeg,</span>
+<span id="cb10-107"><a href="#cb10-107"></a>      <span class="at">code =</span> <span class="st">'ADEG &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adeg"))'</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a>    ),</span>
+<span id="cb10-109"><a href="#cb10-109"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a>  ),</span>
+<span id="cb10-111"><a href="#cb10-111"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-112"><a href="#cb10-112"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-113"><a href="#cb10-113"></a>      <span class="at">label =</span> <span class="st">"ECG Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb10-114"><a href="#cb10-114"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb10-115"><a href="#cb10-115"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-116"><a href="#cb10-116"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-117"><a href="#cb10-117"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-118"><a href="#cb10-118"></a>      ),</span>
+<span id="cb10-119"><a href="#cb10-119"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-120"><a href="#cb10-120"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-121"><a href="#cb10-121"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb10-122"><a href="#cb10-122"></a>      ),</span>
+<span id="cb10-123"><a href="#cb10-123"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-124"><a href="#cb10-124"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb10-125"><a href="#cb10-125"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>)</span>
+<span id="cb10-126"><a href="#cb10-126"></a>      ),</span>
+<span id="cb10-127"><a href="#cb10-127"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-128"><a href="#cb10-128"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-129"><a href="#cb10-129"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adeg, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>        <span class="at">selected =</span> <span class="st">"HR"</span></span>
+<span id="cb10-131"><a href="#cb10-131"></a>      ),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a>    )</span>
+<span id="cb10-134"><a href="#cb10-134"></a>  ),</span>
+<span id="cb10-135"><a href="#cb10-135"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADEG =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb10-136"><a href="#cb10-136"></a>)</span>
+<span id="cb10-137"><a href="#cb10-137"></a></span>
+<span id="cb10-138"><a href="#cb10-138"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-139"><a href="#cb10-139"></a><span class="in">```</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a></span>
+<span id="cb10-141"><a href="#cb10-141"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-142"><a href="#cb10-142"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EGT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ECG Abnormalities (EGT02_1 &amp; EGT02_2)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">ECG Abnormalities Regardless <br> of Abnormality at Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">ECG Abnormalities Among Subjects <br> Without Abnormality at Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="egt02_cache/html/setup_615b6549aaa41482565a79070036a126">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Note:  We keep only post-baseline for analysis.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Heart Rate"</span>, <span class="st">"QT Duration"</span>, <span class="st">"RR Duration"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">filter</span>(ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM =</span> <span class="st">"Assessment"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality"</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="egt02_cache/html/variant1_f3cbf367449f314cebc3b312e85fd5c0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">count_abnormal</span>(<span class="st">"ANRIND"</span>, <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>), <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Assessment        A: Drug X        B: Placebo     C: Combination
+  Abnormality      (N=134)          (N=134)          (N=132)    
+————————————————————————————————————————————————————————————————
+Heart Rate                                                      
+  Low           40/134 (29.9%)   43/134 (32.1%)    37/132 (28%) 
+  High          39/134 (29.1%)   45/134 (33.6%)   36/132 (27.3%)
+QT Duration                                                     
+  Low           33/134 (24.6%)   44/134 (32.8%)   47/132 (35.6%)
+  High          30/134 (22.4%)   42/134 (31.3%)   34/132 (25.8%)
+RR Duration                                                     
+  Low           45/134 (33.6%)   26/134 (19.4%)   38/132 (28.8%)
+  High          29/134 (21.6%)   49/134 (36.6%)   27/132 (20.5%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="egt02_cache/html/variant2_985548d51da6df7d293b79f62d3fc4a9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">count_abnormal</span>(<span class="st">"ANRIND"</span>, <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>), <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-15"><a href="#cb4-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Assessment        A: Drug X        B: Placebo     C: Combination
+  Abnormality      (N=134)          (N=134)          (N=132)    
+————————————————————————————————————————————————————————————————
+Heart Rate                                                      
+  Low           39/128 (30.5%)   42/124 (33.9%)   33/117 (28.2%)
+  High          37/127 (29.1%)   43/129 (33.3%)   31/122 (25.4%)
+QT Duration                                                     
+  Low           29/113 (25.7%)   42/126 (33.3%)   43/124 (34.7%)
+  High           30/125 (24%)    40/130 (30.8%)   30/119 (25.2%)
+RR Duration                                                     
+  Low           45/129 (34.9%)   26/123 (21.1%)   37/126 (29.4%)
+  High          27/127 (21.3%)   43/122 (35.2%)    25/125 (20%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:18}" data-hash="egt02_cache/html/teal_a586fb357fefc04b076e30e47a4a645e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>, adeg, <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")'</span>),</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>  ),</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>      ),</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"EGCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb6-24"><a href="#cb6-24"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>      ),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>      ),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>    )</span>
+<span id="cb6-35"><a href="#cb6-35"></a>  )</span>
+<span id="cb6-36"><a href="#cb6-36"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:13:30.3009 pid:9868 token:[] teal.modules.clinical Initializing tm_t_abnormality</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="egt02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egt02_cache/html/sessioninfo_b4e92316ee68b878ddbc56e8cb42535f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] scda_0.1.6                   dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egt02_cache/html/snapshot_439743aa123d01d9ec6ea0599afe02f9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ECG/egt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
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+    var currentTitle = button.getAttribute("title");
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+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
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+            clickedEl.classList.add('code-annotation-active');
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+            // Unselect the line
+            unselectCodeLines();
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+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ECG/egt01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EGT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/ECG/egt03.html" class="pagination-link">
+        <span class="nav-page-text">EGT03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> EGT02</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> ECG Abnormalities (EGT02_1 &amp; EGT02_2)</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a><span class="co"># Note:  We keep only post-baseline for analysis.</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"Heart Rate"</span>, <span class="st">"QT Duration"</span>, <span class="st">"RR Duration"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="fu">filter</span>(ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    <span class="at">PARAM =</span> <span class="st">"Assessment"</span>,</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality"</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>  )</span>
+<span id="cb12-36"><a href="#cb12-36"></a><span class="in">```</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a></span>
+<span id="cb12-38"><a href="#cb12-38"></a><span class="fu">## ECG Abnormalities Regardless &lt;br/&gt; of Abnormality at Baseline</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a></span>
+<span id="cb12-40"><a href="#cb12-40"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-42"><a href="#cb12-42"></a></span>
+<span id="cb12-43"><a href="#cb12-43"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-46"><a href="#cb12-46"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-48"><a href="#cb12-48"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-49"><a href="#cb12-49"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)</span>
+<span id="cb12-50"><a href="#cb12-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-51"><a href="#cb12-51"></a>  <span class="fu">count_abnormal</span>(<span class="st">"ANRIND"</span>, <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>), <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-52"><a href="#cb12-52"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-53"><a href="#cb12-53"></a></span>
+<span id="cb12-54"><a href="#cb12-54"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-55"><a href="#cb12-55"></a>result</span>
+<span id="cb12-56"><a href="#cb12-56"></a><span class="in">```</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a></span>
+<span id="cb12-58"><a href="#cb12-58"></a><span class="fu">## ECG Abnormalities Among Subjects &lt;br/&gt; Without Abnormality at Baseline</span></span>
+<span id="cb12-59"><a href="#cb12-59"></a></span>
+<span id="cb12-60"><a href="#cb12-60"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-62"><a href="#cb12-62"></a></span>
+<span id="cb12-63"><a href="#cb12-63"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-66"><a href="#cb12-66"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb12-67"><a href="#cb12-67"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-68"><a href="#cb12-68"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-69"><a href="#cb12-69"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM)</span>
+<span id="cb12-70"><a href="#cb12-70"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-71"><a href="#cb12-71"></a>  <span class="fu">count_abnormal</span>(<span class="st">"ANRIND"</span>, <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>), <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-73"><a href="#cb12-73"></a></span>
+<span id="cb12-74"><a href="#cb12-74"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-75"><a href="#cb12-75"></a>result</span>
+<span id="cb12-76"><a href="#cb12-76"></a><span class="in">```</span></span>
+<span id="cb12-77"><a href="#cb12-77"></a></span>
+<span id="cb12-78"><a href="#cb12-78"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-79"><a href="#cb12-79"></a></span>
+<span id="cb12-80"><a href="#cb12-80"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-81"><a href="#cb12-81"></a></span>
+<span id="cb12-82"><a href="#cb12-82"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a><span class="co">#| screenshot.opts = list(delay = 18)</span></span>
+<span id="cb12-84"><a href="#cb12-84"></a></span>
+<span id="cb12-85"><a href="#cb12-85"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-86"><a href="#cb12-86"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-87"><a href="#cb12-87"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-88"><a href="#cb12-88"></a></span>
+<span id="cb12-89"><a href="#cb12-89"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-90"><a href="#cb12-90"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb12-91"><a href="#cb12-91"></a></span>
+<span id="cb12-92"><a href="#cb12-92"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-94"><a href="#cb12-94"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-95"><a href="#cb12-95"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>, adeg, <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")'</span>),</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-97"><a href="#cb12-97"></a>  ),</span>
+<span id="cb12-98"><a href="#cb12-98"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-99"><a href="#cb12-99"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb12-100"><a href="#cb12-100"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb12-101"><a href="#cb12-101"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb12-102"><a href="#cb12-102"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-103"><a href="#cb12-103"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-104"><a href="#cb12-104"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-105"><a href="#cb12-105"></a>      ),</span>
+<span id="cb12-106"><a href="#cb12-106"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-107"><a href="#cb12-107"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"EGCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb12-108"><a href="#cb12-108"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb12-109"><a href="#cb12-109"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-110"><a href="#cb12-110"></a>      ),</span>
+<span id="cb12-111"><a href="#cb12-111"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-112"><a href="#cb12-112"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb12-113"><a href="#cb12-113"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-114"><a href="#cb12-114"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-115"><a href="#cb12-115"></a>      ),</span>
+<span id="cb12-116"><a href="#cb12-116"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb12-117"><a href="#cb12-117"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a>    )</span>
+<span id="cb12-119"><a href="#cb12-119"></a>  )</span>
+<span id="cb12-120"><a href="#cb12-120"></a>)</span>
+<span id="cb12-121"><a href="#cb12-121"></a></span>
+<span id="cb12-122"><a href="#cb12-122"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-123"><a href="#cb12-123"></a><span class="in">```</span></span>
+<span id="cb12-124"><a href="#cb12-124"></a></span>
+<span id="cb12-125"><a href="#cb12-125"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-126"><a href="#cb12-126"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EGT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Shift Table of ECG Interval Data – Baseline Versus Minimum/Maximum Post-Baseline</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Table of Baseline Versus <br> Minimum Post-Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table of Baseline Versus <br> Maximum Post-Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="egt03_cache/html/setup_f7a97002af9348c9cbe3d680223e65de">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adeg_f_pbmin <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  adeg,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  PARAMCD <span class="sc">==</span> <span class="st">"HR"</span> <span class="sc">&amp;</span> <span class="co"># Heart Rate</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>    AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE MINIMUM"</span> <span class="co"># "Analysis Visit"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a>adeg_f_pbmax <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  adeg,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  PARAMCD <span class="sc">==</span> <span class="st">"HR"</span> <span class="sc">&amp;</span> <span class="co"># Heart Rate</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>    AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE MAXIMUM"</span> <span class="co"># "Analysis Visit"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>)</span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="fu">var_labels</span>(adeg_f_pbmin) <span class="ot">&lt;-</span> adeg_labels</span>
+<span id="cb1-29"><a href="#cb1-29"></a><span class="fu">var_labels</span>(adeg_f_pbmax) <span class="ot">&lt;-</span> adeg_labels</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>For the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purposes, missing data are added to the example dataset.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="egt03_cache/html/variant1_3b9ec26a643e291425ab1435c71ec4b2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="fu">set.seed</span>(<span class="dv">123</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>adeg_f_pbmin<span class="sc">$</span>BNRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  adeg_f_pbmin<span class="sc">$</span>BNRIND,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a>adeg_f_pbmin<span class="sc">$</span>ANRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  adeg_f_pbmin<span class="sc">$</span>ANRIND,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>adeg_f_pbmin<span class="sc">$</span>BNRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmin), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>adeg_f_pbmin<span class="sc">$</span>ANRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmin), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a><span class="fu">attr</span>(adeg_f_pbmin<span class="sc">$</span>ANRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Analysis Reference Range Indicator"</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a><span class="fu">attr</span>(adeg_f_pbmin<span class="sc">$</span>BNRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Baseline Reference Range Indicator"</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a></span>
+<span id="cb2-20"><a href="#cb2-20"></a><span class="co"># Temporary solution for overarching column</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>adeg_f_pbmin <span class="ot">&lt;-</span> adeg_f_pbmin <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">min_label =</span> <span class="st">"Minimum Post-Baseline Assessment"</span>)</span>
+<span id="cb2-22"><a href="#cb2-22"></a></span>
+<span id="cb2-23"><a href="#cb2-23"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="fu">split_cols_by</span>(<span class="st">"min_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ANRIND"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARMCD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f_pbmin<span class="sc">$</span>ARMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BNRIND"</span>, <span class="at">denom =</span> <span class="st">"N_row"</span>, <span class="at">.stats =</span> <span class="st">"count_fraction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">append_varlabels</span>(adeg_f_pbmin, <span class="fu">c</span>(<span class="st">"BNRIND"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb2-33"><a href="#cb2-33"></a></span>
+<span id="cb2-34"><a href="#cb2-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="at">df =</span> adeg_f_pbmin</span>
+<span id="cb2-37"><a href="#cb2-37"></a>)</span>
+<span id="cb2-38"><a href="#cb2-38"></a></span>
+<span id="cb2-39"><a href="#cb2-39"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Planned Arm Code                           Minimum Post-Baseline Assessment     
+  Baseline Reference Range Indicator      LOW         NORMAL     HIGH   Missing 
+————————————————————————————————————————————————————————————————————————————————
+ARM A (N=134)                                                                   
+  LOW                                   1 (0.7%)     5 (3.7%)     0        0    
+  NORMAL                               36 (26.9%)   83 (61.9%)    0     1 (0.7%)
+  HIGH                                  2 (1.5%)      4 (3%)      0        0    
+  Missing                               1 (0.7%)        0         0     1 (0.7%)
+ARM B (N=134)                                                                   
+  LOW                                   1 (0.7%)     9 (6.7%)     0        0    
+  NORMAL                               40 (29.9%)    75 (56%)     0     2 (1.5%)
+  HIGH                                  1 (0.7%)      4 (3%)      0        0    
+  Missing                               1 (0.7%)     1 (0.7%)     0        0    
+ARM C (N=132)                                                                   
+  LOW                                    4 (3%)     11 (8.3%)     0        0    
+  NORMAL                               31 (23.5%)   75 (56.8%)    0        0    
+  HIGH                                  1 (0.8%)     8 (6.1%)     0     1 (0.8%)
+  Missing                               1 (0.8%)        0         0        0    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>For the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purpose, missing data are added to the example dataset.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="egt03_cache/html/variant2_bac432eed4280efc2219039a54760f9a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">set.seed</span>(<span class="dv">123</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>adeg_f_pbmax<span class="sc">$</span>BNRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  adeg_f_pbmax<span class="sc">$</span>BNRIND,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a>adeg_f_pbmax<span class="sc">$</span>ANRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  adeg_f_pbmax<span class="sc">$</span>ANRIND,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>adeg_f_pbmax<span class="sc">$</span>BNRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmax), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>adeg_f_pbmax<span class="sc">$</span>ANRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmax), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a></span>
+<span id="cb4-17"><a href="#cb4-17"></a><span class="fu">attr</span>(adeg_f_pbmax<span class="sc">$</span>ANRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Analysis Reference Range Indicator"</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a><span class="fu">attr</span>(adeg_f_pbmax<span class="sc">$</span>BNRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Baseline Reference Range Indicator"</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a></span>
+<span id="cb4-20"><a href="#cb4-20"></a><span class="co"># Temporary solution for overarching column</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>adeg_f_pbmax <span class="ot">&lt;-</span> adeg_f_pbmax <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">max_label =</span> <span class="st">"Maximum Post-Baseline Assessment"</span>)</span>
+<span id="cb4-22"><a href="#cb4-22"></a></span>
+<span id="cb4-23"><a href="#cb4-23"></a><span class="co"># Define the split function</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-25"><a href="#cb4-25"></a></span>
+<span id="cb4-26"><a href="#cb4-26"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="fu">split_cols_by</span>(<span class="st">"max_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ANRIND"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARMCD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f_pbmax<span class="sc">$</span>ARMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BNRIND"</span>, <span class="at">denom =</span> <span class="st">"N_row"</span>, <span class="at">.stats =</span> <span class="st">"count_fraction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>  <span class="fu">append_varlabels</span>(adeg_f_pbmax, <span class="fu">c</span>(<span class="st">"BNRIND"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb4-33"><a href="#cb4-33"></a></span>
+<span id="cb4-34"><a href="#cb4-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>  <span class="at">df =</span> adeg_f_pbmax</span>
+<span id="cb4-37"><a href="#cb4-37"></a>)</span>
+<span id="cb4-38"><a href="#cb4-38"></a></span>
+<span id="cb4-39"><a href="#cb4-39"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Planned Arm Code                           Maximum Post-Baseline Assessment     
+  Baseline Reference Range Indicator   LOW      NORMAL        HIGH      Missing 
+————————————————————————————————————————————————————————————————————————————————
+ARM A (N=134)                                                                   
+  LOW                                   0      2 (1.5%)      4 (3%)        0    
+  NORMAL                                0     88 (65.7%)   31 (23.1%)   1 (0.7%)
+  HIGH                                  0      5 (3.7%)     1 (0.7%)       0    
+  Missing                               0         0         1 (0.7%)    1 (0.7%)
+ARM B (N=134)                                                                   
+  LOW                                   0       8 (6%)      2 (1.5%)       0    
+  NORMAL                                0     76 (56.7%)   39 (29.1%)   2 (1.5%)
+  HIGH                                  0      3 (2.2%)     2 (1.5%)       0    
+  Missing                               0      1 (0.7%)     1 (0.7%)       0    
+ARM C (N=132)                                                                   
+  LOW                                   0     12 (9.1%)     3 (2.3%)       0    
+  NORMAL                                0     79 (59.8%)   27 (20.5%)      0    
+  HIGH                                  0      5 (3.8%)      4 (3%)     1 (0.8%)
+  Missing                               0         0         1 (0.8%)       0    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="egt03_cache/html/teal_b81731f8fc3fdf6a579c3791686536e1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb6-8"><a href="#cb6-8"></a></span>
+<span id="cb6-9"><a href="#cb6-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>, adeg, <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")'</span>),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  ),</span>
+<span id="cb6-15"><a href="#cb6-15"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="fu">tm_t_shift_by_arm</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      <span class="at">label =</span> <span class="st">"Shift by Arm Table"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>        <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-21"><a href="#cb6-21"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>      ),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-24"><a href="#cb6-24"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>        <span class="at">selected =</span> <span class="st">"HR"</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>      ),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"AVISIT"</span>),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>        <span class="at">selected =</span> <span class="st">"POST-BASELINE MINIMUM"</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>      ),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>      ),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      <span class="at">base_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>        <span class="at">selected =</span> <span class="st">"BNRIND"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>      ),</span>
+<span id="cb6-39"><a href="#cb6-39"></a>      <span class="at">treatment_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-40"><a href="#cb6-40"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ONTRTFL"</span>),</span>
+<span id="cb6-41"><a href="#cb6-41"></a>        <span class="at">selected =</span> <span class="st">"ONTRTFL"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>      ),</span>
+<span id="cb6-43"><a href="#cb6-43"></a>      <span class="at">treatment_flag =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-44"><a href="#cb6-44"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"ONTRTFL"</span>),</span>
+<span id="cb6-45"><a href="#cb6-45"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a>      )</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    )</span>
+<span id="cb6-48"><a href="#cb6-48"></a>  ),</span>
+<span id="cb6-49"><a href="#cb6-49"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>))</span>
+<span id="cb6-50"><a href="#cb6-50"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:12:53.6026 pid:9770 token:[] teal.modules.clinical Initializing tm_t_shift_by_arm</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="egt03_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egt03_cache/html/sessioninfo_14a2e66d66a65c0e7cfe45f172c41410">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egt03_cache/html/snapshot_b129738ccee5240f92a0e1eb30b0598c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ECG/egt03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ECG/egt02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EGT02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/ECG/egt04.html" class="pagination-link">
+        <span class="nav-page-text">EGT04</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> EGT03</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Shift Table of ECG Interval Data -- Baseline Versus Minimum/Maximum Post-Baseline</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a></span>
+<span id="cb12-22"><a href="#cb12-22"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-23"><a href="#cb12-23"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb12-24"><a href="#cb12-24"></a></span>
+<span id="cb12-25"><a href="#cb12-25"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a>adeg_f_pbmin <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb12-28"><a href="#cb12-28"></a>  adeg,</span>
+<span id="cb12-29"><a href="#cb12-29"></a>  PARAMCD <span class="sc">==</span> <span class="st">"HR"</span> <span class="sc">&amp;</span> <span class="co"># Heart Rate</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>    AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE MINIMUM"</span> <span class="co"># "Analysis Visit"</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>)</span>
+<span id="cb12-34"><a href="#cb12-34"></a></span>
+<span id="cb12-35"><a href="#cb12-35"></a>adeg_f_pbmax <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb12-36"><a href="#cb12-36"></a>  adeg,</span>
+<span id="cb12-37"><a href="#cb12-37"></a>  PARAMCD <span class="sc">==</span> <span class="st">"HR"</span> <span class="sc">&amp;</span> <span class="co"># Heart Rate</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>    AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE MAXIMUM"</span> <span class="co"># "Analysis Visit"</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>)</span>
+<span id="cb12-42"><a href="#cb12-42"></a></span>
+<span id="cb12-43"><a href="#cb12-43"></a><span class="fu">var_labels</span>(adeg_f_pbmin) <span class="ot">&lt;-</span> adeg_labels</span>
+<span id="cb12-44"><a href="#cb12-44"></a><span class="fu">var_labels</span>(adeg_f_pbmax) <span class="ot">&lt;-</span> adeg_labels</span>
+<span id="cb12-45"><a href="#cb12-45"></a><span class="in">```</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a></span>
+<span id="cb12-47"><a href="#cb12-47"></a><span class="fu">## Table of Baseline Versus &lt;br/&gt; Minimum Post-Baseline</span></span>
+<span id="cb12-48"><a href="#cb12-48"></a></span>
+<span id="cb12-49"><a href="#cb12-49"></a>For the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N.</span>
+<span id="cb12-50"><a href="#cb12-50"></a>For illustration purposes, missing data are added to the example dataset.</span>
+<span id="cb12-51"><a href="#cb12-51"></a></span>
+<span id="cb12-52"><a href="#cb12-52"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a><span class="fu">set.seed</span>(<span class="dv">123</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb12-54"><a href="#cb12-54"></a></span>
+<span id="cb12-55"><a href="#cb12-55"></a>adeg_f_pbmin<span class="sc">$</span>BNRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb12-56"><a href="#cb12-56"></a>  adeg_f_pbmin<span class="sc">$</span>BNRIND,</span>
+<span id="cb12-57"><a href="#cb12-57"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb12-58"><a href="#cb12-58"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb12-59"><a href="#cb12-59"></a>)</span>
+<span id="cb12-60"><a href="#cb12-60"></a>adeg_f_pbmin<span class="sc">$</span>ANRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb12-61"><a href="#cb12-61"></a>  adeg_f_pbmin<span class="sc">$</span>ANRIND,</span>
+<span id="cb12-62"><a href="#cb12-62"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb12-63"><a href="#cb12-63"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb12-64"><a href="#cb12-64"></a>)</span>
+<span id="cb12-65"><a href="#cb12-65"></a></span>
+<span id="cb12-66"><a href="#cb12-66"></a>adeg_f_pbmin<span class="sc">$</span>BNRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmin), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb12-67"><a href="#cb12-67"></a>adeg_f_pbmin<span class="sc">$</span>ANRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmin), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a></span>
+<span id="cb12-69"><a href="#cb12-69"></a><span class="fu">attr</span>(adeg_f_pbmin<span class="sc">$</span>ANRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Analysis Reference Range Indicator"</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a><span class="fu">attr</span>(adeg_f_pbmin<span class="sc">$</span>BNRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Baseline Reference Range Indicator"</span></span>
+<span id="cb12-71"><a href="#cb12-71"></a></span>
+<span id="cb12-72"><a href="#cb12-72"></a><span class="co"># Temporary solution for overarching column</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>adeg_f_pbmin <span class="ot">&lt;-</span> adeg_f_pbmin <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">min_label =</span> <span class="st">"Minimum Post-Baseline Assessment"</span>)</span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-77"><a href="#cb12-77"></a></span>
+<span id="cb12-78"><a href="#cb12-78"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-79"><a href="#cb12-79"></a>  <span class="fu">split_cols_by</span>(<span class="st">"min_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-80"><a href="#cb12-80"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ANRIND"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-81"><a href="#cb12-81"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARMCD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f_pbmin<span class="sc">$</span>ARMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BNRIND"</span>, <span class="at">denom =</span> <span class="st">"N_row"</span>, <span class="at">.stats =</span> <span class="st">"count_fraction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-84"><a href="#cb12-84"></a>  <span class="fu">append_varlabels</span>(adeg_f_pbmin, <span class="fu">c</span>(<span class="st">"BNRIND"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb12-85"><a href="#cb12-85"></a></span>
+<span id="cb12-86"><a href="#cb12-86"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-87"><a href="#cb12-87"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-88"><a href="#cb12-88"></a>  <span class="at">df =</span> adeg_f_pbmin</span>
+<span id="cb12-89"><a href="#cb12-89"></a>)</span>
+<span id="cb12-90"><a href="#cb12-90"></a></span>
+<span id="cb12-91"><a href="#cb12-91"></a>result</span>
+<span id="cb12-92"><a href="#cb12-92"></a><span class="in">```</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a></span>
+<span id="cb12-94"><a href="#cb12-94"></a><span class="fu">## Table of Baseline Versus &lt;br/&gt; Maximum Post-Baseline</span></span>
+<span id="cb12-95"><a href="#cb12-95"></a></span>
+<span id="cb12-96"><a href="#cb12-96"></a>For the EGT03 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N.</span>
+<span id="cb12-97"><a href="#cb12-97"></a>For illustration purpose, missing data are added to the example dataset.</span>
+<span id="cb12-98"><a href="#cb12-98"></a></span>
+<span id="cb12-99"><a href="#cb12-99"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a><span class="fu">set.seed</span>(<span class="dv">123</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb12-101"><a href="#cb12-101"></a></span>
+<span id="cb12-102"><a href="#cb12-102"></a>adeg_f_pbmax<span class="sc">$</span>BNRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb12-103"><a href="#cb12-103"></a>  adeg_f_pbmax<span class="sc">$</span>BNRIND,</span>
+<span id="cb12-104"><a href="#cb12-104"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb12-105"><a href="#cb12-105"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb12-106"><a href="#cb12-106"></a>)</span>
+<span id="cb12-107"><a href="#cb12-107"></a>adeg_f_pbmax<span class="sc">$</span>ANRIND <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb12-108"><a href="#cb12-108"></a>  adeg_f_pbmax<span class="sc">$</span>ANRIND,</span>
+<span id="cb12-109"><a href="#cb12-109"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb12-110"><a href="#cb12-110"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"NORMAL"</span>, <span class="st">"HIGH"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb12-111"><a href="#cb12-111"></a>)</span>
+<span id="cb12-112"><a href="#cb12-112"></a></span>
+<span id="cb12-113"><a href="#cb12-113"></a>adeg_f_pbmax<span class="sc">$</span>BNRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmax), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb12-114"><a href="#cb12-114"></a>adeg_f_pbmax<span class="sc">$</span>ANRIND[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f_pbmax), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb12-115"><a href="#cb12-115"></a></span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="fu">attr</span>(adeg_f_pbmax<span class="sc">$</span>ANRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Analysis Reference Range Indicator"</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="fu">attr</span>(adeg_f_pbmax<span class="sc">$</span>BNRIND, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Baseline Reference Range Indicator"</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a></span>
+<span id="cb12-119"><a href="#cb12-119"></a><span class="co"># Temporary solution for overarching column</span></span>
+<span id="cb12-120"><a href="#cb12-120"></a>adeg_f_pbmax <span class="ot">&lt;-</span> adeg_f_pbmax <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">max_label =</span> <span class="st">"Maximum Post-Baseline Assessment"</span>)</span>
+<span id="cb12-121"><a href="#cb12-121"></a></span>
+<span id="cb12-122"><a href="#cb12-122"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-123"><a href="#cb12-123"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-124"><a href="#cb12-124"></a></span>
+<span id="cb12-125"><a href="#cb12-125"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-126"><a href="#cb12-126"></a>  <span class="fu">split_cols_by</span>(<span class="st">"max_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-127"><a href="#cb12-127"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ANRIND"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-128"><a href="#cb12-128"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARMCD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f_pbmax<span class="sc">$</span>ARMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-129"><a href="#cb12-129"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-130"><a href="#cb12-130"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BNRIND"</span>, <span class="at">denom =</span> <span class="st">"N_row"</span>, <span class="at">.stats =</span> <span class="st">"count_fraction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-131"><a href="#cb12-131"></a>  <span class="fu">append_varlabels</span>(adeg_f_pbmax, <span class="fu">c</span>(<span class="st">"BNRIND"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb12-132"><a href="#cb12-132"></a></span>
+<span id="cb12-133"><a href="#cb12-133"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-134"><a href="#cb12-134"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-135"><a href="#cb12-135"></a>  <span class="at">df =</span> adeg_f_pbmax</span>
+<span id="cb12-136"><a href="#cb12-136"></a>)</span>
+<span id="cb12-137"><a href="#cb12-137"></a></span>
+<span id="cb12-138"><a href="#cb12-138"></a>result</span>
+<span id="cb12-139"><a href="#cb12-139"></a><span class="in">```</span></span>
+<span id="cb12-140"><a href="#cb12-140"></a></span>
+<span id="cb12-141"><a href="#cb12-141"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-142"><a href="#cb12-142"></a></span>
+<span id="cb12-143"><a href="#cb12-143"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-144"><a href="#cb12-144"></a></span>
+<span id="cb12-145"><a href="#cb12-145"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-146"><a href="#cb12-146"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb12-147"><a href="#cb12-147"></a></span>
+<span id="cb12-148"><a href="#cb12-148"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-149"><a href="#cb12-149"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-150"><a href="#cb12-150"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-151"><a href="#cb12-151"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-152"><a href="#cb12-152"></a></span>
+<span id="cb12-153"><a href="#cb12-153"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-154"><a href="#cb12-154"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb12-155"><a href="#cb12-155"></a></span>
+<span id="cb12-156"><a href="#cb12-156"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-157"><a href="#cb12-157"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-158"><a href="#cb12-158"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-159"><a href="#cb12-159"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>, adeg, <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")'</span>),</span>
+<span id="cb12-160"><a href="#cb12-160"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a>  ),</span>
+<span id="cb12-162"><a href="#cb12-162"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-163"><a href="#cb12-163"></a>    <span class="fu">tm_t_shift_by_arm</span>(</span>
+<span id="cb12-164"><a href="#cb12-164"></a>      <span class="at">label =</span> <span class="st">"Shift by Arm Table"</span>,</span>
+<span id="cb12-165"><a href="#cb12-165"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb12-166"><a href="#cb12-166"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-167"><a href="#cb12-167"></a>        <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-168"><a href="#cb12-168"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-169"><a href="#cb12-169"></a>      ),</span>
+<span id="cb12-170"><a href="#cb12-170"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-171"><a href="#cb12-171"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb12-172"><a href="#cb12-172"></a>        <span class="at">selected =</span> <span class="st">"HR"</span></span>
+<span id="cb12-173"><a href="#cb12-173"></a>      ),</span>
+<span id="cb12-174"><a href="#cb12-174"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-175"><a href="#cb12-175"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"AVISIT"</span>),</span>
+<span id="cb12-176"><a href="#cb12-176"></a>        <span class="at">selected =</span> <span class="st">"POST-BASELINE MINIMUM"</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a>      ),</span>
+<span id="cb12-178"><a href="#cb12-178"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-179"><a href="#cb12-179"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb12-180"><a href="#cb12-180"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-181"><a href="#cb12-181"></a>      ),</span>
+<span id="cb12-182"><a href="#cb12-182"></a>      <span class="at">base_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-183"><a href="#cb12-183"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb12-184"><a href="#cb12-184"></a>        <span class="at">selected =</span> <span class="st">"BNRIND"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-185"><a href="#cb12-185"></a>      ),</span>
+<span id="cb12-186"><a href="#cb12-186"></a>      <span class="at">treatment_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-187"><a href="#cb12-187"></a>        <span class="fu">variable_choices</span>(adeg, <span class="at">subset =</span> <span class="st">"ONTRTFL"</span>),</span>
+<span id="cb12-188"><a href="#cb12-188"></a>        <span class="at">selected =</span> <span class="st">"ONTRTFL"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-189"><a href="#cb12-189"></a>      ),</span>
+<span id="cb12-190"><a href="#cb12-190"></a>      <span class="at">treatment_flag =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-191"><a href="#cb12-191"></a>        <span class="fu">value_choices</span>(adeg, <span class="st">"ONTRTFL"</span>),</span>
+<span id="cb12-192"><a href="#cb12-192"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-193"><a href="#cb12-193"></a>      )</span>
+<span id="cb12-194"><a href="#cb12-194"></a>    )</span>
+<span id="cb12-195"><a href="#cb12-195"></a>  ),</span>
+<span id="cb12-196"><a href="#cb12-196"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>))</span>
+<span id="cb12-197"><a href="#cb12-197"></a>)</span>
+<span id="cb12-198"><a href="#cb12-198"></a></span>
+<span id="cb12-199"><a href="#cb12-199"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-200"><a href="#cb12-200"></a><span class="in">```</span></span>
+<span id="cb12-201"><a href="#cb12-201"></a></span>
+<span id="cb12-202"><a href="#cb12-202"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-203"><a href="#cb12-203"></a></span>
+<span id="cb12-204"><a href="#cb12-204"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/ECG/egt04.html
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+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - EGT04</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
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+  { counter-reset: source-line 0; }
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/ECG/egt05_qtcat.html" rel="next">
+<link href="../../tables/ECG/egt03.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EGT04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Shift Table of Qualitative ECG Assessments</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>For the EGT04 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N. For illustration purposes, missing data are added to the example dataset.</p>
+<div class="cell" data-hash="egt04_cache/html/setup_c2156f36a4f49adb7f0441803f997de6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg, <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"AVALC"</span>, <span class="st">"BASEC"</span>))</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adeg_f <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  adeg,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  PARAMCD <span class="sc">==</span> <span class="st">"ECGINTP"</span> <span class="sc">&amp;</span> <span class="co"># Analysis in terms of "NORMAL"/"ABNORMAL" (AVALC)</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>    WORS02FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="co"># "Worst Post-Baseline Observation"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a>adeg_f<span class="sc">$</span>AVALC[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>adeg_f<span class="sc">$</span>BASEC[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adeg_f<span class="sc">$</span>AVALC <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  adeg_f<span class="sc">$</span>AVALC,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">"ABNORMAL"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"Normal"</span>, <span class="st">"Abnormal"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb1-29"><a href="#cb1-29"></a>)</span>
+<span id="cb1-30"><a href="#cb1-30"></a>adeg_f<span class="sc">$</span>BASEC <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>  adeg_f<span class="sc">$</span>BASEC,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">"ABNORMAL"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"Normal"</span>, <span class="st">"Abnormal"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb1-34"><a href="#cb1-34"></a>)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="fu">var_labels</span>(adeg_f) <span class="ot">&lt;-</span> adeg_labels</span>
+<span id="cb1-37"><a href="#cb1-37"></a>adeg_f <span class="ot">&lt;-</span> adeg_f <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="fu">var_relabel</span>(<span class="at">BASEC =</span> <span class="st">"Baseline"</span>)</span>
+<span id="cb1-39"><a href="#cb1-39"></a></span>
+<span id="cb1-40"><a href="#cb1-40"></a><span class="co"># Temprary solution for over arching column</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>adeg_f <span class="ot">&lt;-</span> adeg_f <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">postbaseline_label =</span> <span class="st">"Post-Baseline"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The EGT04 template consists of a stacked list of contingency tables, one per group. For each group, the n’s across all cells must add up to the group N in the analysis, and percentages are calculated using N as the denominator.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="egt04_cache/html/variant1_0713c36f68ba4c3cd231044a5236ad79">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"postbaseline_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVALC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>ARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="st">"BASEC"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">denom =</span> <span class="st">"N_row"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="fu">c</span>(<span class="st">"BASEC"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adeg_f)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Description of Planned Arm             Post-Baseline           
+  Baseline                     Normal      Abnormal    Missing 
+———————————————————————————————————————————————————————————————
+A: Drug X (N=134)                                              
+  Normal                     20 (14.9%)   81 (60.4%)   1 (0.7%)
+  Abnormal                   11 (8.2%)    19 (14.2%)      0    
+  Missing                        0         1 (0.7%)    1 (0.7%)
+B: Placebo (N=134)                                             
+  Normal                     18 (13.4%)   81 (60.4%)   2 (1.5%)
+  Abnormal                    3 (2.2%)    28 (20.9%)      0    
+  Missing                        0         2 (1.5%)       0    
+C: Combination (N=132)                                         
+  Normal                     26 (19.7%)   69 (52.3%)   1 (0.8%)
+  Abnormal                    6 (4.5%)     29 (22%)       0    
+  Missing                     1 (0.8%)        0           0    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="egt04_cache/html/teal_9712f7f68427fb9a80a3a1e265a67efe">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egt04_cache/html/sessioninfo_da06a355a3322002cfff4bff272ed232">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egt04_cache/html/snapshot_8b61a702cd1be1bfe1e1822fa45f3d73">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ECG/egt04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+    const mode = bsSheetEl.getAttribute("data-mode");
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+    if (mode === "dark") {
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+      bodyEl.classList.remove("quarto-light");
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+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> EGT04</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Shift Table of Qualitative ECG Assessments</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>For the EGT04 template, data imputation should be avoided, and missing data explicit and accounted for, so the contingency table sum adds up to the group N.</span>
+<span id="cb8-14"><a href="#cb8-14"></a>For illustration purposes, missing data are added to the example dataset.</span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a></span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-21"><a href="#cb8-21"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-22"><a href="#cb8-22"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-25"><a href="#cb8-25"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-29"><a href="#cb8-29"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg, <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"AVALC"</span>, <span class="st">"BASEC"</span>))</span>
+<span id="cb8-30"><a href="#cb8-30"></a></span>
+<span id="cb8-31"><a href="#cb8-31"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a>adeg_f <span class="ot">&lt;-</span> <span class="fu">subset</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>  adeg,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>  PARAMCD <span class="sc">==</span> <span class="st">"ECGINTP"</span> <span class="sc">&amp;</span> <span class="co"># Analysis in terms of "NORMAL"/"ABNORMAL" (AVALC)</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "Safety Population Flag"</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>    ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="co"># "On Treatment Record Flag"</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>    WORS02FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="co"># "Worst Post-Baseline Observation"</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>)</span>
+<span id="cb8-40"><a href="#cb8-40"></a></span>
+<span id="cb8-41"><a href="#cb8-41"></a>adeg_f<span class="sc">$</span>AVALC[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>adeg_f<span class="sc">$</span>BASEC[<span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="fu">nrow</span>(adeg_f), <span class="at">size =</span> <span class="dv">5</span>)] <span class="ot">&lt;-</span> <span class="st">"Missing"</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>adeg_f<span class="sc">$</span>AVALC <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>  adeg_f<span class="sc">$</span>AVALC,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">"ABNORMAL"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"Normal"</span>, <span class="st">"Abnormal"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb8-47"><a href="#cb8-47"></a>)</span>
+<span id="cb8-48"><a href="#cb8-48"></a>adeg_f<span class="sc">$</span>BASEC <span class="ot">&lt;-</span> <span class="fu">factor</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>  adeg_f<span class="sc">$</span>BASEC,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"NORMAL"</span>, <span class="st">"ABNORMAL"</span>, <span class="st">"Missing"</span>),</span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="at">labels =</span> <span class="fu">c</span>(<span class="st">"Normal"</span>, <span class="st">"Abnormal"</span>, <span class="st">"Missing"</span>)</span>
+<span id="cb8-52"><a href="#cb8-52"></a>)</span>
+<span id="cb8-53"><a href="#cb8-53"></a></span>
+<span id="cb8-54"><a href="#cb8-54"></a><span class="fu">var_labels</span>(adeg_f) <span class="ot">&lt;-</span> adeg_labels</span>
+<span id="cb8-55"><a href="#cb8-55"></a>adeg_f <span class="ot">&lt;-</span> adeg_f <span class="sc">%&gt;%</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="fu">var_relabel</span>(<span class="at">BASEC =</span> <span class="st">"Baseline"</span>)</span>
+<span id="cb8-57"><a href="#cb8-57"></a></span>
+<span id="cb8-58"><a href="#cb8-58"></a><span class="co"># Temprary solution for over arching column</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a>adeg_f <span class="ot">&lt;-</span> adeg_f <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">postbaseline_label =</span> <span class="st">"Post-Baseline"</span>)</span>
+<span id="cb8-60"><a href="#cb8-60"></a><span class="in">```</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a></span>
+<span id="cb8-62"><a href="#cb8-62"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a>The EGT04 template consists of a stacked list of contingency tables, one per group.</span>
+<span id="cb8-65"><a href="#cb8-65"></a>For each group, the n's across all cells must add up to the group N in the analysis, and percentages are calculated using N as the denominator.</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a><span class="co"># Define the split function</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-70"><a href="#cb8-70"></a></span>
+<span id="cb8-71"><a href="#cb8-71"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="fu">split_cols_by</span>(<span class="st">"postbaseline_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVALC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ARM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>ARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a>  <span class="fu">add_rowcounts</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-77"><a href="#cb8-77"></a>    <span class="st">"BASEC"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>    <span class="at">denom =</span> <span class="st">"N_row"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a>  <span class="fu">append_varlabels</span>(adeg_f, <span class="fu">c</span>(<span class="st">"BASEC"</span>), <span class="at">indent =</span> 1L)</span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adeg_f)</span>
+<span id="cb8-85"><a href="#cb8-85"></a>result</span>
+<span id="cb8-86"><a href="#cb8-86"></a><span class="in">```</span></span>
+<span id="cb8-87"><a href="#cb8-87"></a></span>
+<span id="cb8-88"><a href="#cb8-88"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-89"><a href="#cb8-89"></a></span>
+<span id="cb8-90"><a href="#cb8-90"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-91"><a href="#cb8-91"></a></span>
+<span id="cb8-92"><a href="#cb8-92"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-93"><a href="#cb8-93"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-94"><a href="#cb8-94"></a></span>
+<span id="cb8-95"><a href="#cb8-95"></a><span class="co"># In progress</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a><span class="in">```</span></span>
+<span id="cb8-97"><a href="#cb8-97"></a></span>
+<span id="cb8-98"><a href="#cb8-98"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-99"><a href="#cb8-99"></a></span>
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diff --git a/stable/tables/ECG/egt05_qtcat.html b/stable/tables/ECG/egt05_qtcat.html
new file mode 100644
index 0000000000..23145bda3a
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+ <span class="menu-text">AET06</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
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+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<div class="quarto-title-block"><div><h1 class="title">EGT05_QTCAT</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ECG Actual Values and Changes from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="egt05_qtcat_cache/html/setup_2051bcef7cfdfe340ef566c89b4527eb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">==</span> <span class="st">"QT"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">450</span> <span class="sc">~</span> <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">480</span> <span class="sc">~</span> <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      AVAL <span class="sc">&gt;</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="fu">is.na</span>(AVAL) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      CHG <span class="sc">&gt;</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="fu">is.na</span>(CHG) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>    )</span>
+<span id="cb1-32"><a href="#cb1-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      AVALCAT1,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>        <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>        <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>        <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>      )</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    ),</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-45"><a href="#cb1-45"></a>      CHGCAT1,</span>
+<span id="cb1-46"><a href="#cb1-46"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-47"><a href="#cb1-47"></a>        <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>        <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>        <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>      )</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    )</span>
+<span id="cb1-53"><a href="#cb1-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    <span class="at">AVALCAT1 =</span> <span class="st">"Value at Visit"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>    <span class="at">CHGCAT1 =</span> <span class="st">"Change from Baseline"</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="egt05_qtcat_cache/html/variant1_0f6a19b42d1f504870abe8c2342ac1f5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>AVISIT),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>),</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from Baseline"</span>)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Category"</span>)</span>
+<span id="cb2-22"><a href="#cb2-22"></a></span>
+<span id="cb2-23"><a href="#cb2-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                             
+  Analysis Visit             A: Drug X    B: Placebo    C: Combination
+    Category                  (N=134)       (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————
+QT Duration                                                           
+  BASELINE                                                            
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            115 (85.8%)   117 (87.3%)    104 (78.8%)  
+      &gt;450 to &lt;=480 msec     6 (4.5%)      10 (7.5%)       9 (6.8%)   
+      &gt;480 to &lt;= 500 msec     4 (3%)       3 (2.2%)        6 (4.5%)   
+      &gt;500 msec              9 (6.7%)       4 (3%)        13 (9.8%)   
+  WEEK 1 DAY 8                                                        
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            113 (84.3%)   106 (79.1%)    106 (80.3%)  
+      &gt;450 to &lt;=480 msec     10 (7.5%)     10 (7.5%)      11 (8.3%)   
+      &gt;480 to &lt;= 500 msec     4 (3%)        4 (3%)         3 (2.3%)   
+      &gt;500 msec              7 (5.2%)     14 (10.4%)      12 (9.1%)   
+    Change from Baseline                                              
+      n                         134           134            132      
+      &lt;=30 msec             76 (56.7%)     75 (56%)       75 (56.8%)  
+      &gt;30 to &lt;=60 msec       7 (5.2%)      13 (9.7%)      11 (8.3%)   
+      &gt;60 msec              51 (38.1%)    46 (34.3%)      46 (34.8%)  
+  WEEK 2 DAY 15                                                       
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            111 (82.8%)   114 (85.1%)    112 (84.8%)  
+      &gt;450 to &lt;=480 msec     10 (7.5%)     9 (6.7%)        9 (6.8%)   
+      &gt;480 to &lt;= 500 msec    7 (5.2%)      2 (1.5%)        5 (3.8%)   
+      &gt;500 msec              6 (4.5%)      9 (6.7%)        6 (4.5%)   
+    Change from Baseline                                              
+      n                         134           134            132      
+      &lt;=30 msec              71 (53%)     87 (64.9%)      89 (67.4%)  
+      &gt;30 to &lt;=60 msec       11 (8.2%)     9 (6.7%)        9 (6.8%)   
+      &gt;60 msec              52 (38.8%)    38 (28.4%)      34 (25.8%)  
+  WEEK 3 DAY 22                                                       
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            106 (79.1%)   112 (83.6%)    118 (89.4%)  
+      &gt;450 to &lt;=480 msec     13 (9.7%)     7 (5.2%)        3 (2.3%)   
+      &gt;480 to &lt;= 500 msec     4 (3%)       5 (3.7%)        2 (1.5%)   
+      &gt;500 msec              11 (8.2%)     10 (7.5%)       9 (6.8%)   
+    Change from Baseline                                              
+      n                         134           134            132      
+      &lt;=30 msec              63 (47%)     80 (59.7%)      81 (61.4%)  
+      &gt;30 to &lt;=60 msec      14 (10.4%)      8 (6%)        11 (8.3%)   
+      &gt;60 msec              57 (42.5%)    46 (34.3%)      40 (30.3%)  
+  WEEK 4 DAY 29                                                       
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            117 (87.3%)   103 (76.9%)    114 (86.4%)  
+      &gt;450 to &lt;=480 msec     7 (5.2%)     14 (10.4%)       6 (4.5%)   
+      &gt;480 to &lt;= 500 msec     4 (3%)       7 (5.2%)        3 (2.3%)   
+      &gt;500 msec              6 (4.5%)      10 (7.5%)       9 (6.8%)   
+    Change from Baseline                                              
+      n                         134           134            132      
+      &lt;=30 msec              79 (59%)     80 (59.7%)      79 (59.8%)  
+      &gt;30 to &lt;=60 msec       11 (8.2%)     7 (5.2%)       10 (7.6%)   
+      &gt;60 msec              44 (32.8%)    47 (35.1%)      43 (32.6%)  
+  WEEK 5 DAY 36                                                       
+    Value at Visit                                                    
+      n                         134           134            132      
+      &lt;=450 msec            107 (79.9%)   117 (87.3%)    112 (84.8%)  
+      &gt;450 to &lt;=480 msec    16 (11.9%)     5 (3.7%)       13 (9.8%)   
+      &gt;480 to &lt;= 500 msec    5 (3.7%)      9 (6.7%)        3 (2.3%)   
+      &gt;500 msec              6 (4.5%)      3 (2.2%)         4 (3%)    
+    Change from Baseline                                              
+      n                         134           134            132      
+      &lt;=30 msec             72 (53.7%)    82 (61.2%)      73 (55.3%)  
+      &gt;30 to &lt;=60 msec       10 (7.5%)     11 (8.2%)      11 (8.3%)   
+      &gt;60 msec              52 (38.8%)    41 (30.6%)      48 (36.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:24}" data-hash="egt05_qtcat_cache/html/teal_ba0b6a9661c2c10fb34c63cbee246f8b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-8"><a href="#cb4-8"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb4-9"><a href="#cb4-9"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="co"># no need to filter for PARAMCD here</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb4-17"><a href="#cb4-17"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">450</span> <span class="sc">~</span> <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">480</span> <span class="sc">~</span> <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      AVAL <span class="sc">&gt;</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      <span class="fu">is.na</span>(AVAL) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>    ),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      CHG <span class="sc">&gt;</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="fu">is.na</span>(CHG) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>    )</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      AVALCAT1,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-34"><a href="#cb4-34"></a>        <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>        <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>        <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>        <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb4-38"><a href="#cb4-38"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>      )</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    ),</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>      CHGCAT1,</span>
+<span id="cb4-43"><a href="#cb4-43"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-44"><a href="#cb4-44"></a>        <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>        <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>        <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb4-47"><a href="#cb4-47"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>      )</span>
+<span id="cb4-49"><a href="#cb4-49"></a>    )</span>
+<span id="cb4-50"><a href="#cb4-50"></a>  )</span>
+<span id="cb4-51"><a href="#cb4-51"></a><span class="fu">var_labels</span>(adeg_f) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb4-52"><a href="#cb4-52"></a>  adeg_labels,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>  <span class="st">"AVALCAT1"</span> <span class="ot">=</span> <span class="st">"Value at Visit"</span>,</span>
+<span id="cb4-54"><a href="#cb4-54"></a>  <span class="st">"CHGCAT1"</span> <span class="ot">=</span> <span class="st">"Change from Baseline"</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a>)</span>
+<span id="cb4-56"><a href="#cb4-56"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-57"><a href="#cb4-57"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-58"><a href="#cb4-58"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb4-59"><a href="#cb4-59"></a>      adsl,</span>
+<span id="cb4-60"><a href="#cb4-60"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb4-61"><a href="#cb4-61"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)'</span></span>
+<span id="cb4-62"><a href="#cb4-62"></a>    ),</span>
+<span id="cb4-63"><a href="#cb4-63"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>,</span>
+<span id="cb4-64"><a href="#cb4-64"></a>      adeg_f,</span>
+<span id="cb4-65"><a href="#cb4-65"></a>      <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")</span></span>
+<span id="cb4-66"><a href="#cb4-66"></a><span class="st">                  ADEG &lt;- df_explicit_na(ADEG)</span></span>
+<span id="cb4-67"><a href="#cb4-67"></a><span class="st">                  ADEG_labels &lt;- var_labels(ADEG)</span></span>
+<span id="cb4-68"><a href="#cb4-68"></a></span>
+<span id="cb4-69"><a href="#cb4-69"></a><span class="st">                  ADEG &lt;- ADEG %&gt;%</span></span>
+<span id="cb4-70"><a href="#cb4-70"></a><span class="st">                    filter(</span></span>
+<span id="cb4-71"><a href="#cb4-71"></a><span class="st">                      ANL01FL == "Y"</span></span>
+<span id="cb4-72"><a href="#cb4-72"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb4-73"><a href="#cb4-73"></a><span class="st">                     mutate(</span></span>
+<span id="cb4-74"><a href="#cb4-74"></a><span class="st">                      AVALCAT1 = case_when(</span></span>
+<span id="cb4-75"><a href="#cb4-75"></a><span class="st">                        AVAL &lt;= 450 ~ "&lt;=450 msec",</span></span>
+<span id="cb4-76"><a href="#cb4-76"></a><span class="st">                        AVAL &lt;= 480 ~ "&gt;450 to &lt;=480 msec",</span></span>
+<span id="cb4-77"><a href="#cb4-77"></a><span class="st">                        AVAL &lt;= 500 ~ "&gt;480 to &lt;= 500 msec",</span></span>
+<span id="cb4-78"><a href="#cb4-78"></a><span class="st">                        AVAL &gt; 500 ~ "&gt;500 msec",</span></span>
+<span id="cb4-79"><a href="#cb4-79"></a><span class="st">                        is.na(AVAL) ~ "&lt;Missing&gt;"),</span></span>
+<span id="cb4-80"><a href="#cb4-80"></a><span class="st">                      CHGCAT1 = case_when(</span></span>
+<span id="cb4-81"><a href="#cb4-81"></a><span class="st">                        CHG &lt;= 30 ~ "&lt;=30 msec",</span></span>
+<span id="cb4-82"><a href="#cb4-82"></a><span class="st">                        CHG &lt;= 60 ~ "&gt;30 to &lt;=60 msec",</span></span>
+<span id="cb4-83"><a href="#cb4-83"></a><span class="st">                        CHG &gt; 60 ~ "&gt;60 msec",</span></span>
+<span id="cb4-84"><a href="#cb4-84"></a><span class="st">                        is.na(CHG) ~ "&lt;Missing&gt;")</span></span>
+<span id="cb4-85"><a href="#cb4-85"></a><span class="st">                    ) %&gt;% mutate(</span></span>
+<span id="cb4-86"><a href="#cb4-86"></a><span class="st">                      AVALCAT1 = factor(</span></span>
+<span id="cb4-87"><a href="#cb4-87"></a><span class="st">                        AVALCAT1,</span></span>
+<span id="cb4-88"><a href="#cb4-88"></a><span class="st">                        levels = c(</span></span>
+<span id="cb4-89"><a href="#cb4-89"></a><span class="st">                          "&lt;=450 msec",</span></span>
+<span id="cb4-90"><a href="#cb4-90"></a><span class="st">                          "&gt;450 to &lt;=480 msec",</span></span>
+<span id="cb4-91"><a href="#cb4-91"></a><span class="st">                          "&gt;480 to &lt;= 500 msec",</span></span>
+<span id="cb4-92"><a href="#cb4-92"></a><span class="st">                          "&gt;500 msec",</span></span>
+<span id="cb4-93"><a href="#cb4-93"></a><span class="st">                          "&lt;Missing&gt;"</span></span>
+<span id="cb4-94"><a href="#cb4-94"></a><span class="st">                        )</span></span>
+<span id="cb4-95"><a href="#cb4-95"></a><span class="st">                      ),</span></span>
+<span id="cb4-96"><a href="#cb4-96"></a><span class="st">                      CHGCAT1 = factor(</span></span>
+<span id="cb4-97"><a href="#cb4-97"></a><span class="st">                        CHGCAT1,</span></span>
+<span id="cb4-98"><a href="#cb4-98"></a><span class="st">                        levels = c(</span></span>
+<span id="cb4-99"><a href="#cb4-99"></a><span class="st">                          "&lt;=30 msec",</span></span>
+<span id="cb4-100"><a href="#cb4-100"></a><span class="st">                          "&gt;30 to &lt;=60 msec",</span></span>
+<span id="cb4-101"><a href="#cb4-101"></a><span class="st">                          "&gt;60 msec",</span></span>
+<span id="cb4-102"><a href="#cb4-102"></a><span class="st">                          "&lt;Missing&gt;"</span></span>
+<span id="cb4-103"><a href="#cb4-103"></a><span class="st">                        )</span></span>
+<span id="cb4-104"><a href="#cb4-104"></a><span class="st">                      )</span></span>
+<span id="cb4-105"><a href="#cb4-105"></a><span class="st">                    )</span></span>
+<span id="cb4-106"><a href="#cb4-106"></a><span class="st">                  var_labels(ADEG) &lt;- c(</span></span>
+<span id="cb4-107"><a href="#cb4-107"></a><span class="st">                    ADEG_labels,</span></span>
+<span id="cb4-108"><a href="#cb4-108"></a><span class="st">                    "AVALCAT1" = "Value at Visit",</span></span>
+<span id="cb4-109"><a href="#cb4-109"></a><span class="st">                    "CHGCAT1" = "Change from Baseline"</span></span>
+<span id="cb4-110"><a href="#cb4-110"></a><span class="st">                  )'</span></span>
+<span id="cb4-111"><a href="#cb4-111"></a>    ),</span>
+<span id="cb4-112"><a href="#cb4-112"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-113"><a href="#cb4-113"></a>  ),</span>
+<span id="cb4-114"><a href="#cb4-114"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-115"><a href="#cb4-115"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-116"><a href="#cb4-116"></a>      <span class="at">label =</span> <span class="st">"ECG Actual Values and Changes from Baseline by Visit"</span>,</span>
+<span id="cb4-117"><a href="#cb4-117"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb4-118"><a href="#cb4-118"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-119"><a href="#cb4-119"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-120"><a href="#cb4-120"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-121"><a href="#cb4-121"></a>      ),</span>
+<span id="cb4-122"><a href="#cb4-122"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-123"><a href="#cb4-123"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg_f, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-124"><a href="#cb4-124"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb4-125"><a href="#cb4-125"></a>      ),</span>
+<span id="cb4-126"><a href="#cb4-126"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-127"><a href="#cb4-127"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg_f, <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>)),</span>
+<span id="cb4-128"><a href="#cb4-128"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>)</span>
+<span id="cb4-129"><a href="#cb4-129"></a>      ),</span>
+<span id="cb4-130"><a href="#cb4-130"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-131"><a href="#cb4-131"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-132"><a href="#cb4-132"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adeg_f, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-133"><a href="#cb4-133"></a>        <span class="at">selected =</span> <span class="st">"QT"</span></span>
+<span id="cb4-134"><a href="#cb4-134"></a>      )</span>
+<span id="cb4-135"><a href="#cb4-135"></a>    )</span>
+<span id="cb4-136"><a href="#cb4-136"></a>  )</span>
+<span id="cb4-137"><a href="#cb4-137"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:12:10.1697 pid:9672 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="egt05_qtcat_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="egt05_qtcat_cache/html/sessioninfo_7c4be7a0a77f437587fbc62be753d026">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="egt05_qtcat_cache/html/snapshot_92fd656e2912ee60f1fb3bb759b3f6a6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/ECG/egt05_qtcat.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+      }
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ECG/egt04.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EGT04</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/aovt01.html" class="pagination-link">
+        <span class="nav-page-text">AOVT01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> EGT05_QTCAT</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> ECG Actual Values and Changes from Baseline by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb10-28"><a href="#cb10-28"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    PARAMCD <span class="sc">==</span> <span class="st">"QT"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-35"><a href="#cb10-35"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">450</span> <span class="sc">~</span> <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb10-36"><a href="#cb10-36"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">480</span> <span class="sc">~</span> <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb10-37"><a href="#cb10-37"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      AVAL <span class="sc">&gt;</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb10-39"><a href="#cb10-39"></a>      <span class="fu">is.na</span>(AVAL) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>    ),</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb10-44"><a href="#cb10-44"></a>      CHG <span class="sc">&gt;</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb10-45"><a href="#cb10-45"></a>      <span class="fu">is.na</span>(CHG) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>    )</span>
+<span id="cb10-47"><a href="#cb10-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-50"><a href="#cb10-50"></a>      AVALCAT1,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-52"><a href="#cb10-52"></a>        <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>        <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb10-54"><a href="#cb10-54"></a>        <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>        <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>      )</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    ),</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-60"><a href="#cb10-60"></a>      CHGCAT1,</span>
+<span id="cb10-61"><a href="#cb10-61"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-62"><a href="#cb10-62"></a>        <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>        <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>        <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb10-65"><a href="#cb10-65"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a>      )</span>
+<span id="cb10-67"><a href="#cb10-67"></a>    )</span>
+<span id="cb10-68"><a href="#cb10-68"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb10-70"><a href="#cb10-70"></a>    <span class="at">AVALCAT1 =</span> <span class="st">"Value at Visit"</span>,</span>
+<span id="cb10-71"><a href="#cb10-71"></a>    <span class="at">CHGCAT1 =</span> <span class="st">"Change from Baseline"</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  )</span>
+<span id="cb10-73"><a href="#cb10-73"></a><span class="in">```</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a></span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-78"><a href="#cb10-78"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-79"><a href="#cb10-79"></a></span>
+<span id="cb10-80"><a href="#cb10-80"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-82"><a href="#cb10-82"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-83"><a href="#cb10-83"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb10-84"><a href="#cb10-84"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>PARAM),</span>
+<span id="cb10-85"><a href="#cb10-85"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-86"><a href="#cb10-86"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-89"><a href="#cb10-89"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb10-90"><a href="#cb10-90"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adeg_f<span class="sc">$</span>AVISIT),</span>
+<span id="cb10-91"><a href="#cb10-91"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-92"><a href="#cb10-92"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb10-93"><a href="#cb10-93"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-94"><a href="#cb10-94"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb10-95"><a href="#cb10-95"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>),</span>
+<span id="cb10-96"><a href="#cb10-96"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from Baseline"</span>)</span>
+<span id="cb10-97"><a href="#cb10-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Category"</span>)</span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adeg_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb10-102"><a href="#cb10-102"></a></span>
+<span id="cb10-103"><a href="#cb10-103"></a>result</span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="in">```</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a></span>
+<span id="cb10-106"><a href="#cb10-106"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-107"><a href="#cb10-107"></a></span>
+<span id="cb10-108"><a href="#cb10-108"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a></span>
+<span id="cb10-110"><a href="#cb10-110"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-111"><a href="#cb10-111"></a><span class="co">#| screenshot.opts = list(delay = 24)</span></span>
+<span id="cb10-112"><a href="#cb10-112"></a></span>
+<span id="cb10-113"><a href="#cb10-113"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-114"><a href="#cb10-114"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-115"><a href="#cb10-115"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-116"><a href="#cb10-116"></a></span>
+<span id="cb10-117"><a href="#cb10-117"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-118"><a href="#cb10-118"></a>adeg <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adeg"</span>)</span>
+<span id="cb10-119"><a href="#cb10-119"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-120"><a href="#cb10-120"></a>adeg <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adeg)</span>
+<span id="cb10-121"><a href="#cb10-121"></a>adeg_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adeg)</span>
+<span id="cb10-122"><a href="#cb10-122"></a></span>
+<span id="cb10-123"><a href="#cb10-123"></a>adeg_f <span class="ot">&lt;-</span> adeg <span class="sc">%&gt;%</span></span>
+<span id="cb10-124"><a href="#cb10-124"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-125"><a href="#cb10-125"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="co"># no need to filter for PARAMCD here</span></span>
+<span id="cb10-126"><a href="#cb10-126"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-128"><a href="#cb10-128"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-129"><a href="#cb10-129"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">450</span> <span class="sc">~</span> <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb10-130"><a href="#cb10-130"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">480</span> <span class="sc">~</span> <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb10-131"><a href="#cb10-131"></a>      AVAL <span class="sc">&lt;=</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb10-132"><a href="#cb10-132"></a>      AVAL <span class="sc">&gt;</span> <span class="dv">500</span> <span class="sc">~</span> <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb10-133"><a href="#cb10-133"></a>      <span class="fu">is.na</span>(AVAL) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-134"><a href="#cb10-134"></a>    ),</span>
+<span id="cb10-135"><a href="#cb10-135"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-136"><a href="#cb10-136"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb10-137"><a href="#cb10-137"></a>      CHG <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb10-138"><a href="#cb10-138"></a>      CHG <span class="sc">&gt;</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb10-139"><a href="#cb10-139"></a>      <span class="fu">is.na</span>(CHG) <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a>    )</span>
+<span id="cb10-141"><a href="#cb10-141"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-142"><a href="#cb10-142"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-143"><a href="#cb10-143"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-144"><a href="#cb10-144"></a>      AVALCAT1,</span>
+<span id="cb10-145"><a href="#cb10-145"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-146"><a href="#cb10-146"></a>        <span class="st">"&lt;=450 msec"</span>,</span>
+<span id="cb10-147"><a href="#cb10-147"></a>        <span class="st">"&gt;450 to &lt;=480 msec"</span>,</span>
+<span id="cb10-148"><a href="#cb10-148"></a>        <span class="st">"&gt;480 to &lt;= 500 msec"</span>,</span>
+<span id="cb10-149"><a href="#cb10-149"></a>        <span class="st">"&gt;500 msec"</span>,</span>
+<span id="cb10-150"><a href="#cb10-150"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-151"><a href="#cb10-151"></a>      )</span>
+<span id="cb10-152"><a href="#cb10-152"></a>    ),</span>
+<span id="cb10-153"><a href="#cb10-153"></a>    <span class="at">CHGCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-154"><a href="#cb10-154"></a>      CHGCAT1,</span>
+<span id="cb10-155"><a href="#cb10-155"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-156"><a href="#cb10-156"></a>        <span class="st">"&lt;=30 msec"</span>,</span>
+<span id="cb10-157"><a href="#cb10-157"></a>        <span class="st">"&gt;30 to &lt;=60 msec"</span>,</span>
+<span id="cb10-158"><a href="#cb10-158"></a>        <span class="st">"&gt;60 msec"</span>,</span>
+<span id="cb10-159"><a href="#cb10-159"></a>        <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb10-160"><a href="#cb10-160"></a>      )</span>
+<span id="cb10-161"><a href="#cb10-161"></a>    )</span>
+<span id="cb10-162"><a href="#cb10-162"></a>  )</span>
+<span id="cb10-163"><a href="#cb10-163"></a><span class="fu">var_labels</span>(adeg_f) <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb10-164"><a href="#cb10-164"></a>  adeg_labels,</span>
+<span id="cb10-165"><a href="#cb10-165"></a>  <span class="st">"AVALCAT1"</span> <span class="ot">=</span> <span class="st">"Value at Visit"</span>,</span>
+<span id="cb10-166"><a href="#cb10-166"></a>  <span class="st">"CHGCAT1"</span> <span class="ot">=</span> <span class="st">"Change from Baseline"</span></span>
+<span id="cb10-167"><a href="#cb10-167"></a>)</span>
+<span id="cb10-168"><a href="#cb10-168"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-169"><a href="#cb10-169"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-170"><a href="#cb10-170"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb10-171"><a href="#cb10-171"></a>      adsl,</span>
+<span id="cb10-172"><a href="#cb10-172"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb10-173"><a href="#cb10-173"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)'</span></span>
+<span id="cb10-174"><a href="#cb10-174"></a>    ),</span>
+<span id="cb10-175"><a href="#cb10-175"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEG"</span>,</span>
+<span id="cb10-176"><a href="#cb10-176"></a>      adeg_f,</span>
+<span id="cb10-177"><a href="#cb10-177"></a>      <span class="at">code =</span> <span class="st">'ADEG &lt;- synthetic_cdisc_dataset("latest", "adeg")</span></span>
+<span id="cb10-178"><a href="#cb10-178"></a><span class="st">                  ADEG &lt;- df_explicit_na(ADEG)</span></span>
+<span id="cb10-179"><a href="#cb10-179"></a><span class="st">                  ADEG_labels &lt;- var_labels(ADEG)</span></span>
+<span id="cb10-180"><a href="#cb10-180"></a></span>
+<span id="cb10-181"><a href="#cb10-181"></a><span class="st">                  ADEG &lt;- ADEG %&gt;%</span></span>
+<span id="cb10-182"><a href="#cb10-182"></a><span class="st">                    filter(</span></span>
+<span id="cb10-183"><a href="#cb10-183"></a><span class="st">                      ANL01FL == "Y"</span></span>
+<span id="cb10-184"><a href="#cb10-184"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb10-185"><a href="#cb10-185"></a><span class="st">                     mutate(</span></span>
+<span id="cb10-186"><a href="#cb10-186"></a><span class="st">                      AVALCAT1 = case_when(</span></span>
+<span id="cb10-187"><a href="#cb10-187"></a><span class="st">                        AVAL &lt;= 450 ~ "&lt;=450 msec",</span></span>
+<span id="cb10-188"><a href="#cb10-188"></a><span class="st">                        AVAL &lt;= 480 ~ "&gt;450 to &lt;=480 msec",</span></span>
+<span id="cb10-189"><a href="#cb10-189"></a><span class="st">                        AVAL &lt;= 500 ~ "&gt;480 to &lt;= 500 msec",</span></span>
+<span id="cb10-190"><a href="#cb10-190"></a><span class="st">                        AVAL &gt; 500 ~ "&gt;500 msec",</span></span>
+<span id="cb10-191"><a href="#cb10-191"></a><span class="st">                        is.na(AVAL) ~ "&lt;Missing&gt;"),</span></span>
+<span id="cb10-192"><a href="#cb10-192"></a><span class="st">                      CHGCAT1 = case_when(</span></span>
+<span id="cb10-193"><a href="#cb10-193"></a><span class="st">                        CHG &lt;= 30 ~ "&lt;=30 msec",</span></span>
+<span id="cb10-194"><a href="#cb10-194"></a><span class="st">                        CHG &lt;= 60 ~ "&gt;30 to &lt;=60 msec",</span></span>
+<span id="cb10-195"><a href="#cb10-195"></a><span class="st">                        CHG &gt; 60 ~ "&gt;60 msec",</span></span>
+<span id="cb10-196"><a href="#cb10-196"></a><span class="st">                        is.na(CHG) ~ "&lt;Missing&gt;")</span></span>
+<span id="cb10-197"><a href="#cb10-197"></a><span class="st">                    ) %&gt;% mutate(</span></span>
+<span id="cb10-198"><a href="#cb10-198"></a><span class="st">                      AVALCAT1 = factor(</span></span>
+<span id="cb10-199"><a href="#cb10-199"></a><span class="st">                        AVALCAT1,</span></span>
+<span id="cb10-200"><a href="#cb10-200"></a><span class="st">                        levels = c(</span></span>
+<span id="cb10-201"><a href="#cb10-201"></a><span class="st">                          "&lt;=450 msec",</span></span>
+<span id="cb10-202"><a href="#cb10-202"></a><span class="st">                          "&gt;450 to &lt;=480 msec",</span></span>
+<span id="cb10-203"><a href="#cb10-203"></a><span class="st">                          "&gt;480 to &lt;= 500 msec",</span></span>
+<span id="cb10-204"><a href="#cb10-204"></a><span class="st">                          "&gt;500 msec",</span></span>
+<span id="cb10-205"><a href="#cb10-205"></a><span class="st">                          "&lt;Missing&gt;"</span></span>
+<span id="cb10-206"><a href="#cb10-206"></a><span class="st">                        )</span></span>
+<span id="cb10-207"><a href="#cb10-207"></a><span class="st">                      ),</span></span>
+<span id="cb10-208"><a href="#cb10-208"></a><span class="st">                      CHGCAT1 = factor(</span></span>
+<span id="cb10-209"><a href="#cb10-209"></a><span class="st">                        CHGCAT1,</span></span>
+<span id="cb10-210"><a href="#cb10-210"></a><span class="st">                        levels = c(</span></span>
+<span id="cb10-211"><a href="#cb10-211"></a><span class="st">                          "&lt;=30 msec",</span></span>
+<span id="cb10-212"><a href="#cb10-212"></a><span class="st">                          "&gt;30 to &lt;=60 msec",</span></span>
+<span id="cb10-213"><a href="#cb10-213"></a><span class="st">                          "&gt;60 msec",</span></span>
+<span id="cb10-214"><a href="#cb10-214"></a><span class="st">                          "&lt;Missing&gt;"</span></span>
+<span id="cb10-215"><a href="#cb10-215"></a><span class="st">                        )</span></span>
+<span id="cb10-216"><a href="#cb10-216"></a><span class="st">                      )</span></span>
+<span id="cb10-217"><a href="#cb10-217"></a><span class="st">                    )</span></span>
+<span id="cb10-218"><a href="#cb10-218"></a><span class="st">                  var_labels(ADEG) &lt;- c(</span></span>
+<span id="cb10-219"><a href="#cb10-219"></a><span class="st">                    ADEG_labels,</span></span>
+<span id="cb10-220"><a href="#cb10-220"></a><span class="st">                    "AVALCAT1" = "Value at Visit",</span></span>
+<span id="cb10-221"><a href="#cb10-221"></a><span class="st">                    "CHGCAT1" = "Change from Baseline"</span></span>
+<span id="cb10-222"><a href="#cb10-222"></a><span class="st">                  )'</span></span>
+<span id="cb10-223"><a href="#cb10-223"></a>    ),</span>
+<span id="cb10-224"><a href="#cb10-224"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-225"><a href="#cb10-225"></a>  ),</span>
+<span id="cb10-226"><a href="#cb10-226"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-227"><a href="#cb10-227"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-228"><a href="#cb10-228"></a>      <span class="at">label =</span> <span class="st">"ECG Actual Values and Changes from Baseline by Visit"</span>,</span>
+<span id="cb10-229"><a href="#cb10-229"></a>      <span class="at">dataname =</span> <span class="st">"ADEG"</span>,</span>
+<span id="cb10-230"><a href="#cb10-230"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-231"><a href="#cb10-231"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-232"><a href="#cb10-232"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-233"><a href="#cb10-233"></a>      ),</span>
+<span id="cb10-234"><a href="#cb10-234"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-235"><a href="#cb10-235"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg_f, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-236"><a href="#cb10-236"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb10-237"><a href="#cb10-237"></a>      ),</span>
+<span id="cb10-238"><a href="#cb10-238"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-239"><a href="#cb10-239"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adeg_f, <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>)),</span>
+<span id="cb10-240"><a href="#cb10-240"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVALCAT1"</span>, <span class="st">"CHGCAT1"</span>)</span>
+<span id="cb10-241"><a href="#cb10-241"></a>      ),</span>
+<span id="cb10-242"><a href="#cb10-242"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-243"><a href="#cb10-243"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-244"><a href="#cb10-244"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adeg_f, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-245"><a href="#cb10-245"></a>        <span class="at">selected =</span> <span class="st">"QT"</span></span>
+<span id="cb10-246"><a href="#cb10-246"></a>      )</span>
+<span id="cb10-247"><a href="#cb10-247"></a>    )</span>
+<span id="cb10-248"><a href="#cb10-248"></a>  )</span>
+<span id="cb10-249"><a href="#cb10-249"></a>)</span>
+<span id="cb10-250"><a href="#cb10-250"></a></span>
+<span id="cb10-251"><a href="#cb10-251"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-252"><a href="#cb10-252"></a><span class="in">```</span></span>
+<span id="cb10-253"><a href="#cb10-253"></a></span>
+<span id="cb10-254"><a href="#cb10-254"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-255"><a href="#cb10-255"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/adverse-events/aet01.html
@@ -0,0 +1,2899 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/adverse-events/aet01_aesi.html" rel="next">
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "location": "navbar",
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+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
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+<li class="sidebar-item">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+</li>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Safety Summary</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Medical <br> Concepts Section</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with <br> Modified Rows</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Rows Counting <br> Events &amp; Additional Sections</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>To illustrate, additional variables such as flags (TRUE/FALSE) for select AEs of interest and select AE baskets are added to the <code>adae</code> dataset.</p>
+<div class="cell" data-hash="aet01_cache/html/setup_761efc466770ed5cd4597064b47c7948">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  adae,</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01SC"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"SMQ02SC"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="fu">set.seed</span>(<span class="dv">99</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AEDECOD =</span> <span class="fu">with_label</span>(<span class="fu">as.character</span>(AEDECOD), <span class="st">"Dictionary-Derived Term"</span>),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">AESDTH =</span> <span class="fu">with_label</span>(<span class="fu">sample</span>(<span class="fu">c</span>(<span class="st">"N"</span>, <span class="st">"Y"</span>), <span class="at">size =</span> <span class="fu">nrow</span>(adae), <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.99</span>, <span class="fl">0.01</span>)), <span class="st">"Results in Death"</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">AEACN =</span> <span class="fu">with_label</span>(<span class="fu">sample</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="fu">c</span>(<span class="st">"DOSE NOT CHANGED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DRUG WITHDRAWN"</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adae),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.68</span>, <span class="fl">0.02</span>, <span class="fl">0.25</span>, <span class="fl">0.05</span>)</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ), <span class="st">"Action Taken with Study Treatment"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">FATAL =</span> <span class="fu">with_label</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"AE with fatal outcome"</span>),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">SEV =</span> <span class="fu">with_label</span>(AESEV <span class="sc">==</span> <span class="st">"SEVERE"</span>, <span class="st">"Severe AE (at greatest intensity)"</span>),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE"</span>),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Serious AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="st">"Serious AE leading to dose modification/interruption"</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>    ),</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related Serious AE"</span>),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"AE leading to dose modification/interruption"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>    ),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE"</span>),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Related AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb1-43"><a href="#cb1-43"></a>      <span class="st">"Related AE leading to dose modification/interruption"</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>    ),</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">CTC35 =</span> <span class="fu">with_label</span>(AETOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>), <span class="st">"Grade 3-5 AE"</span>),</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">CTC45 =</span> <span class="fu">with_label</span>(AETOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"4"</span>, <span class="st">"5"</span>), <span class="st">"Grade 4/5 AE"</span>),</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">SMQ01 =</span> <span class="fu">with_label</span>(SMQ01NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>SMQ01NAM, adae<span class="sc">$</span>SMQ01SC)),</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">SMQ02 =</span> <span class="fu">with_label</span>(SMQ02NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>SMQ02NAM, adae<span class="sc">$</span>SMQ02SC)),</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">CQ01 =</span> <span class="fu">with_label</span>(CQ01NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>CQ01NAM)),</span>
+<span id="cb1-50"><a href="#cb1-50"></a>    <span class="at">USUBJID_AESEQ =</span> <span class="fu">paste</span>(USUBJID, AESEQ, <span class="at">sep =</span> <span class="st">"@@"</span>) <span class="co"># Create unique ID per AE in dataset.</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet01_cache/html/variant1_1eff11152a6f736c2ff8403ec7f186d3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"RELSER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"SEV"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  )</span>
+<span id="cb2-19"><a href="#cb2-19"></a></span>
+<span id="cb2-20"><a href="#cb2-20"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-21"><a href="#cb2-21"></a></span>
+<span id="cb2-22"><a href="#cb2-22"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>    ),</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-34"><a href="#cb2-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  )</span>
+<span id="cb2-42"><a href="#cb2-42"></a></span>
+<span id="cb2-43"><a href="#cb2-43"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-44"><a href="#cb2-44"></a></span>
+<span id="cb2-45"><a href="#cb2-45"></a><span class="co"># Combine tables.</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb2-47"><a href="#cb2-47"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb2-48"><a href="#cb2-48"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb2-49"><a href="#cb2-49"></a>  result_adsl,</span>
+<span id="cb2-50"><a href="#cb2-50"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb2-51"><a href="#cb2-51"></a>)</span>
+<span id="cb2-52"><a href="#cb2-52"></a></span>
+<span id="cb2-53"><a href="#cb2-53"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                              A: Drug X    B: Placebo   C: Combination
+                                                               (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                              502          480            604      
+Total number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  
+Total number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   
+Total number of patients with at least one                                                            
+  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   
+  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  Serious AE leading to withdrawal from treatment             6 (4.5%)     12 (9.0%)       9 (6.8%)   
+  Serious AE leading to dose modification/interruption       36 (26.9%)    40 (29.9%)     47 (35.6%)  
+  Related Serious AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  
+  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  
+  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  Related AE leading to withdrawal from treatment             10 (7.5%)     9 (6.7%)      12 (9.1%)   
+  Related AE leading to dose modification/interruption       44 (32.8%)    44 (32.8%)     51 (38.6%)  
+  Severe AE (at greatest intensity)                          77 (57.5%)    70 (52.2%)     79 (59.8%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet01_cache/html/variant2_80db22dc36ede9811c74b00639de6926">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"RELSER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"CTC35"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a>basket_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SMQ01"</span>, <span class="st">"SMQ02"</span>, <span class="st">"CQ01"</span>)</span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>  )</span>
+<span id="cb4-20"><a href="#cb4-20"></a></span>
+<span id="cb4-21"><a href="#cb4-21"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-22"><a href="#cb4-22"></a></span>
+<span id="cb4-23"><a href="#cb4-23"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-30"><a href="#cb4-30"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>    ),</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-36"><a href="#cb4-36"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb4-42"><a href="#cb4-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-44"><a href="#cb4-44"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">flag_variables =</span> basket_vars,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">table_names =</span> <span class="st">"table_aesi"</span>,</span>
+<span id="cb4-47"><a href="#cb4-47"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-48"><a href="#cb4-48"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb4-49"><a href="#cb4-49"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb4-50"><a href="#cb4-50"></a>  )</span>
+<span id="cb4-51"><a href="#cb4-51"></a></span>
+<span id="cb4-52"><a href="#cb4-52"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-53"><a href="#cb4-53"></a></span>
+<span id="cb4-54"><a href="#cb4-54"></a><span class="co"># Combine tables.</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb4-56"><a href="#cb4-56"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb4-57"><a href="#cb4-57"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb4-58"><a href="#cb4-58"></a>  result_adsl,</span>
+<span id="cb4-59"><a href="#cb4-59"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb4-60"><a href="#cb4-60"></a>)</span>
+<span id="cb4-61"><a href="#cb4-61"></a></span>
+<span id="cb4-62"><a href="#cb4-62"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                              A: Drug X    B: Placebo   C: Combination
+                                                               (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                              502          480            604      
+Total number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  
+Total number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   
+Total number of patients with at least one                                                            
+  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   
+  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  Serious AE leading to withdrawal from treatment             6 (4.5%)     12 (9.0%)       9 (6.8%)   
+  Serious AE leading to dose modification/interruption       36 (26.9%)    40 (29.9%)     47 (35.6%)  
+  Related Serious AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  
+  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  
+  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  Related AE leading to withdrawal from treatment             10 (7.5%)     9 (6.7%)      12 (9.1%)   
+  Related AE leading to dose modification/interruption       44 (32.8%)    44 (32.8%)     51 (38.6%)  
+  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  
+Total number of patients with at least one                                                            
+  C.1.1.1.3/B.2.2.3.1 AESI (BROAD)                           58 (43.3%)    60 (44.8%)     66 (50.0%)  
+  SMQ 02 Reference Name                                           0            0              0       
+  D.2.1.5.3/A.1.1.1.1 AESI                                   62 (46.3%)    61 (45.5%)     76 (57.6%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet01_cache/html/variant3_c774c6bfab5374970aefeba14d136f13">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"WD"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"WITHDRAWAL BY SUBJECT"</span>),</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn informed consent"</span>),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">table_names =</span> <span class="st">"tot_dscsreas_wd"</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>  )</span>
+<span id="cb6-25"><a href="#cb6-25"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb6-26"><a href="#cb6-26"></a></span>
+<span id="cb6-27"><a href="#cb6-27"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>    ),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb6-38"><a href="#cb6-38"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a>  )</span>
+<span id="cb6-47"><a href="#cb6-47"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb6-48"><a href="#cb6-48"></a></span>
+<span id="cb6-49"><a href="#cb6-49"></a><span class="co"># Combine tables.</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb6-51"><a href="#cb6-51"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb6-52"><a href="#cb6-52"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb6-53"><a href="#cb6-53"></a>  result_adsl,</span>
+<span id="cb6-54"><a href="#cb6-54"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb6-55"><a href="#cb6-55"></a>)</span>
+<span id="cb6-56"><a href="#cb6-56"></a></span>
+<span id="cb6-57"><a href="#cb6-57"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                              A: Drug X    B: Placebo   C: Combination
+                                                               (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                              502          480            604      
+Total number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  
+Total number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   
+Total number of patients withdrawn informed consent           1 (0.7%)      1 (0.7%)       1 (0.8%)   
+Total number of patients with at least one                                                            
+  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   
+  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  
+  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  
+  Grade 4/5 AE                                               77 (57.5%)    70 (52.2%)     79 (59.8%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet01_cache/html/variant4_b0dde2494ccab9f0ed47bafa3e5380cb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>count_subj_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a>count_term_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb8-3"><a href="#cb8-3"></a>count_ae_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb8-4"><a href="#cb8-4"></a></span>
+<span id="cb8-5"><a href="#cb8-5"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb8-13"><a href="#cb8-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb8-20"><a href="#cb8-20"></a>  )</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-31"><a href="#cb8-31"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb8-32"><a href="#cb8-32"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>    ),</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb8-35"><a href="#cb8-35"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">flag_variables =</span> count_subj_vars,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">flag_variables =</span> count_term_vars,</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"xx"</span>),</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">table_names =</span> <span class="st">"table_term"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of unique preferred terms which are"</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="st">"USUBJID_AESEQ"</span>,</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="at">flag_variables =</span> count_ae_vars,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"xx"</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">table_names =</span> <span class="st">"table_ae"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of adverse events which are"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  )</span>
+<span id="cb8-62"><a href="#cb8-62"></a></span>
+<span id="cb8-63"><a href="#cb8-63"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-64"><a href="#cb8-64"></a></span>
+<span id="cb8-65"><a href="#cb8-65"></a><span class="co"># Combine tables.</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb8-67"><a href="#cb8-67"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb8-68"><a href="#cb8-68"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb8-69"><a href="#cb8-69"></a>  result_adsl,</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb8-71"><a href="#cb8-71"></a>)</span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                              A: Drug X    B: Placebo   C: Combination
+                                                               (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                              502          480            604      
+Total number of deaths                                       25 (18.7%)    23 (17.2%)     22 (16.7%)  
+Total number of patients withdrawn from study due to an AE    3 (2.2%)      6 (4.5%)       5 (3.8%)   
+Total number of patients with at least one                                                            
+  AE with fatal outcome                                       5 (3.7%)      5 (3.7%)       6 (4.5%)   
+  Serious AE                                                 85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  AE leading to withdrawal from treatment                    20 (14.9%)    24 (17.9%)     26 (19.7%)  
+  AE leading to dose modification/interruption               63 (47.0%)    70 (52.2%)     77 (58.3%)  
+  Related AE                                                 86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  Grade 3-5 AE                                               90 (67.2%)    83 (61.9%)     93 (70.5%)  
+Total number of unique preferred terms which are                                                      
+  Serious AE                                                      4            4              4       
+  AE leading to dose modification/interruption                   10            10             10      
+  Related AE                                                      5            5              5       
+  Grade 3-5 AE                                                    5            5              5       
+  Grade 4/5 AE                                                    3            3              3       
+Total number of adverse events which are                                                              
+  Serious AE                                                     204          194            245      
+  AE leading to dose modification/interruption                   123          135            158      
+  Related AE                                                     231          231            290      
+  Grade 3-5 AE                                                   249          229            277      
+  Grade 4/5 AE                                                   143          134            168      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet01_cache/html/teal_51152c9bbcddd9f2263fd0b21608f71c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>add_event_flags <span class="ot">&lt;-</span> <span class="cf">function</span>(dat) {</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  dat <span class="sc">%&gt;%</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb10-11"><a href="#cb10-11"></a>      <span class="at">TMPFL_SER =</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb10-12"><a href="#cb10-12"></a>      <span class="at">TMPFL_REL =</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb10-13"><a href="#cb10-13"></a>      <span class="at">TMPFL_GR5 =</span> AETOXGR <span class="sc">==</span> <span class="st">"5"</span>,</span>
+<span id="cb10-14"><a href="#cb10-14"></a>      <span class="at">TMP_SMQ01 =</span> <span class="sc">!</span><span class="fu">is.na</span>(SMQ01NAM),</span>
+<span id="cb10-15"><a href="#cb10-15"></a>      <span class="at">TMP_SMQ02 =</span> <span class="sc">!</span><span class="fu">is.na</span>(SMQ02NAM),</span>
+<span id="cb10-16"><a href="#cb10-16"></a>      <span class="at">TMP_CQ01 =</span> <span class="sc">!</span><span class="fu">is.na</span>(CQ01NAM)</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="fu">var_relabel</span>(</span>
+<span id="cb10-19"><a href="#cb10-19"></a>      <span class="at">TMPFL_SER =</span> <span class="st">"Serious AE"</span>,</span>
+<span id="cb10-20"><a href="#cb10-20"></a>      <span class="at">TMPFL_REL =</span> <span class="st">"Related AE"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      <span class="at">TMPFL_GR5 =</span> <span class="st">"Grade 5 AE"</span>,</span>
+<span id="cb10-22"><a href="#cb10-22"></a>      <span class="at">TMP_SMQ01 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"SMQ01NAM"</span>]], dat[[<span class="st">"SMQ01SC"</span>]]),</span>
+<span id="cb10-23"><a href="#cb10-23"></a>      <span class="at">TMP_SMQ02 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"SMQ02NAM"</span>]], dat[[<span class="st">"SMQ02SC"</span>]]),</span>
+<span id="cb10-24"><a href="#cb10-24"></a>      <span class="at">TMP_CQ01 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"CQ01NAM"</span>]])</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    )</span>
+<span id="cb10-26"><a href="#cb10-26"></a>}</span>
+<span id="cb10-27"><a href="#cb10-27"></a></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="co"># Generating user-defined event flags.</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">add_event_flags</span>()</span>
+<span id="cb10-30"><a href="#cb10-30"></a></span>
+<span id="cb10-31"><a href="#cb10-31"></a>ae_anl_vars <span class="ot">&lt;-</span> <span class="fu">names</span>(adae)[<span class="fu">startsWith</span>(<span class="fu">names</span>(adae), <span class="st">"TMPFL_"</span>)]</span>
+<span id="cb10-32"><a href="#cb10-32"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">names</span>(adae)[<span class="fu">startsWith</span>(<span class="fu">names</span>(adae), <span class="st">"TMP_"</span>)]</span>
+<span id="cb10-33"><a href="#cb10-33"></a></span>
+<span id="cb10-34"><a href="#cb10-34"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="st">      add_event_flags &lt;- function(dat) {</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="st">        dat %&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="st">          dplyr::mutate(</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a><span class="st">            TMPFL_SER = AESER == "Y",</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a><span class="st">            TMPFL_REL = AEREL == "Y",</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a><span class="st">            TMPFL_GR5 = AETOXGR == "5",</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="st">            TMP_SMQ01 = !is.na(SMQ01NAM),</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a><span class="st">            TMP_SMQ02 = !is.na(SMQ02NAM),</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a><span class="st">            TMP_CQ01 = !is.na(CQ01NAM)</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a><span class="st">          ) %&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a><span class="st">          var_relabel(</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a><span class="st">            TMPFL_SER = "Serious AE",</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a><span class="st">            TMPFL_REL = "Related AE",</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a><span class="st">            TMPFL_GR5 = "Grade 5 AE",</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a><span class="st">            TMP_SMQ01 = aesi_label(dat[["SMQ01NAM"]], dat[["SMQ01SC"]]),</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a><span class="st">            TMP_SMQ02 = aesi_label(dat[["SMQ02NAM"]], dat[["SMQ02SC"]]),</span></span>
+<span id="cb10-54"><a href="#cb10-54"></a><span class="st">            TMP_CQ01 = aesi_label(dat[["CQ01NAM"]])</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a><span class="st">          )</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a><span class="st">      }</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a><span class="st">      ADAE &lt;- ADAE %&gt;% add_event_flags()'</span>),</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>  ),</span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="fu">tm_t_events_summary</span>(</span>
+<span id="cb10-62"><a href="#cb10-62"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Summary"</span>,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-65"><a href="#cb10-65"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADSL"</span>, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-66"><a href="#cb10-66"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a>      ),</span>
+<span id="cb10-68"><a href="#cb10-68"></a>      <span class="at">flag_var_anl =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-69"><a href="#cb10-69"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, ae_anl_vars),</span>
+<span id="cb10-70"><a href="#cb10-70"></a>        <span class="at">selected =</span> ae_anl_vars[<span class="dv">1</span>],</span>
+<span id="cb10-71"><a href="#cb10-71"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-72"><a href="#cb10-72"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>      ),</span>
+<span id="cb10-74"><a href="#cb10-74"></a>      <span class="at">flag_var_aesi =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-75"><a href="#cb10-75"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, aesi_vars),</span>
+<span id="cb10-76"><a href="#cb10-76"></a>        <span class="at">selected =</span> aesi_vars[<span class="dv">1</span>],</span>
+<span id="cb10-77"><a href="#cb10-77"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-78"><a href="#cb10-78"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-79"><a href="#cb10-79"></a>      ),</span>
+<span id="cb10-80"><a href="#cb10-80"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a>    )</span>
+<span id="cb10-82"><a href="#cb10-82"></a>  )</span>
+<span id="cb10-83"><a href="#cb10-83"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:22:18.1116 pid:11292 token:[] teal.modules.clinical Initializing tm_t_events_summary</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet01_cache/html/sessioninfo_3fd58245a9cd84373e36693a78463c80">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet01_cache/html/snapshot_56cb15e6264836c08bbeef254087cd7f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+    if (bsSheetEl) {
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+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
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+      window.scrollTo(0, 1);
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+  } else {
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+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
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+    placement: 'right',
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+  const isCodeAnnotation = (el) => {
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
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+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
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+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
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+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
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+          window.location.href = sourceUrl;
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+      }
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
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+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ADAT04B</span>
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+        <span class="nav-page-text">AET01_AESI</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> AET01</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Safety Summary</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a>To illustrate, additional variables such as flags (TRUE/FALSE) for select AEs of interest and select AE baskets are added to the <span class="in">`adae`</span> dataset.</span>
+<span id="cb16-14"><a href="#cb16-14"></a></span>
+<span id="cb16-15"><a href="#cb16-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-17"><a href="#cb16-17"></a></span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-19"><a href="#cb16-19"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-20"><a href="#cb16-20"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-21"><a href="#cb16-21"></a></span>
+<span id="cb16-22"><a href="#cb16-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-23"><a href="#cb16-23"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-24"><a href="#cb16-24"></a></span>
+<span id="cb16-25"><a href="#cb16-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-26"><a href="#cb16-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-27"><a href="#cb16-27"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(</span>
+<span id="cb16-28"><a href="#cb16-28"></a>  adae,</span>
+<span id="cb16-29"><a href="#cb16-29"></a>  <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01SC"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"SMQ02SC"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb16-30"><a href="#cb16-30"></a>)</span>
+<span id="cb16-31"><a href="#cb16-31"></a></span>
+<span id="cb16-32"><a href="#cb16-32"></a><span class="fu">set.seed</span>(<span class="dv">99</span>)</span>
+<span id="cb16-33"><a href="#cb16-33"></a></span>
+<span id="cb16-34"><a href="#cb16-34"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-35"><a href="#cb16-35"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-36"><a href="#cb16-36"></a>    <span class="at">AEDECOD =</span> <span class="fu">with_label</span>(<span class="fu">as.character</span>(AEDECOD), <span class="st">"Dictionary-Derived Term"</span>),</span>
+<span id="cb16-37"><a href="#cb16-37"></a>    <span class="at">AESDTH =</span> <span class="fu">with_label</span>(<span class="fu">sample</span>(<span class="fu">c</span>(<span class="st">"N"</span>, <span class="st">"Y"</span>), <span class="at">size =</span> <span class="fu">nrow</span>(adae), <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.99</span>, <span class="fl">0.01</span>)), <span class="st">"Results in Death"</span>),</span>
+<span id="cb16-38"><a href="#cb16-38"></a>    <span class="at">AEACN =</span> <span class="fu">with_label</span>(<span class="fu">sample</span>(</span>
+<span id="cb16-39"><a href="#cb16-39"></a>      <span class="fu">c</span>(<span class="st">"DOSE NOT CHANGED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DRUG WITHDRAWN"</span>),</span>
+<span id="cb16-40"><a href="#cb16-40"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adae),</span>
+<span id="cb16-41"><a href="#cb16-41"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.68</span>, <span class="fl">0.02</span>, <span class="fl">0.25</span>, <span class="fl">0.05</span>)</span>
+<span id="cb16-42"><a href="#cb16-42"></a>    ), <span class="st">"Action Taken with Study Treatment"</span>),</span>
+<span id="cb16-43"><a href="#cb16-43"></a>    <span class="at">FATAL =</span> <span class="fu">with_label</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"AE with fatal outcome"</span>),</span>
+<span id="cb16-44"><a href="#cb16-44"></a>    <span class="at">SEV =</span> <span class="fu">with_label</span>(AESEV <span class="sc">==</span> <span class="st">"SEVERE"</span>, <span class="st">"Severe AE (at greatest intensity)"</span>),</span>
+<span id="cb16-45"><a href="#cb16-45"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE"</span>),</span>
+<span id="cb16-46"><a href="#cb16-46"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Serious AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb16-47"><a href="#cb16-47"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-48"><a href="#cb16-48"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-49"><a href="#cb16-49"></a>      <span class="st">"Serious AE leading to dose modification/interruption"</span></span>
+<span id="cb16-50"><a href="#cb16-50"></a>    ),</span>
+<span id="cb16-51"><a href="#cb16-51"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related Serious AE"</span>),</span>
+<span id="cb16-52"><a href="#cb16-52"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb16-53"><a href="#cb16-53"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-54"><a href="#cb16-54"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"AE leading to dose modification/interruption"</span></span>
+<span id="cb16-55"><a href="#cb16-55"></a>    ),</span>
+<span id="cb16-56"><a href="#cb16-56"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE"</span>),</span>
+<span id="cb16-57"><a href="#cb16-57"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Related AE leading to withdrawal from treatment"</span>),</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-59"><a href="#cb16-59"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-60"><a href="#cb16-60"></a>      <span class="st">"Related AE leading to dose modification/interruption"</span></span>
+<span id="cb16-61"><a href="#cb16-61"></a>    ),</span>
+<span id="cb16-62"><a href="#cb16-62"></a>    <span class="at">CTC35 =</span> <span class="fu">with_label</span>(AETOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>), <span class="st">"Grade 3-5 AE"</span>),</span>
+<span id="cb16-63"><a href="#cb16-63"></a>    <span class="at">CTC45 =</span> <span class="fu">with_label</span>(AETOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"4"</span>, <span class="st">"5"</span>), <span class="st">"Grade 4/5 AE"</span>),</span>
+<span id="cb16-64"><a href="#cb16-64"></a>    <span class="at">SMQ01 =</span> <span class="fu">with_label</span>(SMQ01NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>SMQ01NAM, adae<span class="sc">$</span>SMQ01SC)),</span>
+<span id="cb16-65"><a href="#cb16-65"></a>    <span class="at">SMQ02 =</span> <span class="fu">with_label</span>(SMQ02NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>SMQ02NAM, adae<span class="sc">$</span>SMQ02SC)),</span>
+<span id="cb16-66"><a href="#cb16-66"></a>    <span class="at">CQ01 =</span> <span class="fu">with_label</span>(CQ01NAM <span class="sc">!=</span> <span class="st">""</span>, <span class="fu">aesi_label</span>(adae<span class="sc">$</span>CQ01NAM)),</span>
+<span id="cb16-67"><a href="#cb16-67"></a>    <span class="at">USUBJID_AESEQ =</span> <span class="fu">paste</span>(USUBJID, AESEQ, <span class="at">sep =</span> <span class="st">"@@"</span>) <span class="co"># Create unique ID per AE in dataset.</span></span>
+<span id="cb16-68"><a href="#cb16-68"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-69"><a href="#cb16-69"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-70"><a href="#cb16-70"></a><span class="in">```</span></span>
+<span id="cb16-71"><a href="#cb16-71"></a></span>
+<span id="cb16-72"><a href="#cb16-72"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-73"><a href="#cb16-73"></a></span>
+<span id="cb16-74"><a href="#cb16-74"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"RELSER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"SEV"</span>)</span>
+<span id="cb16-76"><a href="#cb16-76"></a></span>
+<span id="cb16-77"><a href="#cb16-77"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb16-78"><a href="#cb16-78"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-79"><a href="#cb16-79"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-80"><a href="#cb16-80"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-81"><a href="#cb16-81"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-82"><a href="#cb16-82"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-83"><a href="#cb16-83"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-84"><a href="#cb16-84"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb16-85"><a href="#cb16-85"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-86"><a href="#cb16-86"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-87"><a href="#cb16-87"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-88"><a href="#cb16-88"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb16-89"><a href="#cb16-89"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-90"><a href="#cb16-90"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb16-91"><a href="#cb16-91"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>  )</span>
+<span id="cb16-93"><a href="#cb16-93"></a></span>
+<span id="cb16-94"><a href="#cb16-94"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-95"><a href="#cb16-95"></a></span>
+<span id="cb16-96"><a href="#cb16-96"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb16-97"><a href="#cb16-97"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-98"><a href="#cb16-98"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-99"><a href="#cb16-99"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-100"><a href="#cb16-100"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-101"><a href="#cb16-101"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-102"><a href="#cb16-102"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-103"><a href="#cb16-103"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb16-104"><a href="#cb16-104"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb16-105"><a href="#cb16-105"></a>    ),</span>
+<span id="cb16-106"><a href="#cb16-106"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-107"><a href="#cb16-107"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-108"><a href="#cb16-108"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-110"><a href="#cb16-110"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-111"><a href="#cb16-111"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb16-112"><a href="#cb16-112"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-113"><a href="#cb16-113"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb16-114"><a href="#cb16-114"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-115"><a href="#cb16-115"></a>  )</span>
+<span id="cb16-116"><a href="#cb16-116"></a></span>
+<span id="cb16-117"><a href="#cb16-117"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-118"><a href="#cb16-118"></a></span>
+<span id="cb16-119"><a href="#cb16-119"></a><span class="co"># Combine tables.</span></span>
+<span id="cb16-120"><a href="#cb16-120"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb16-121"><a href="#cb16-121"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb16-122"><a href="#cb16-122"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb16-123"><a href="#cb16-123"></a>  result_adsl,</span>
+<span id="cb16-124"><a href="#cb16-124"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb16-125"><a href="#cb16-125"></a>)</span>
+<span id="cb16-126"><a href="#cb16-126"></a></span>
+<span id="cb16-127"><a href="#cb16-127"></a>result</span>
+<span id="cb16-128"><a href="#cb16-128"></a><span class="in">```</span></span>
+<span id="cb16-129"><a href="#cb16-129"></a></span>
+<span id="cb16-130"><a href="#cb16-130"></a><span class="fu">## Table with Medical &lt;br/&gt; Concepts Section</span></span>
+<span id="cb16-131"><a href="#cb16-131"></a></span>
+<span id="cb16-132"><a href="#cb16-132"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-133"><a href="#cb16-133"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"RELSER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"CTC35"</span>)</span>
+<span id="cb16-134"><a href="#cb16-134"></a>basket_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SMQ01"</span>, <span class="st">"SMQ02"</span>, <span class="st">"CQ01"</span>)</span>
+<span id="cb16-135"><a href="#cb16-135"></a></span>
+<span id="cb16-136"><a href="#cb16-136"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb16-137"><a href="#cb16-137"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-138"><a href="#cb16-138"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-139"><a href="#cb16-139"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-140"><a href="#cb16-140"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-141"><a href="#cb16-141"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-142"><a href="#cb16-142"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-143"><a href="#cb16-143"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb16-144"><a href="#cb16-144"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-145"><a href="#cb16-145"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-146"><a href="#cb16-146"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-147"><a href="#cb16-147"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb16-148"><a href="#cb16-148"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-149"><a href="#cb16-149"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb16-150"><a href="#cb16-150"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a>  )</span>
+<span id="cb16-152"><a href="#cb16-152"></a></span>
+<span id="cb16-153"><a href="#cb16-153"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-154"><a href="#cb16-154"></a></span>
+<span id="cb16-155"><a href="#cb16-155"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb16-156"><a href="#cb16-156"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-157"><a href="#cb16-157"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-159"><a href="#cb16-159"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-160"><a href="#cb16-160"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-161"><a href="#cb16-161"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-162"><a href="#cb16-162"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb16-163"><a href="#cb16-163"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb16-164"><a href="#cb16-164"></a>    ),</span>
+<span id="cb16-165"><a href="#cb16-165"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-166"><a href="#cb16-166"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-167"><a href="#cb16-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-168"><a href="#cb16-168"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-169"><a href="#cb16-169"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-170"><a href="#cb16-170"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb16-171"><a href="#cb16-171"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-172"><a href="#cb16-172"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb16-173"><a href="#cb16-173"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-175"><a href="#cb16-175"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-176"><a href="#cb16-176"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-177"><a href="#cb16-177"></a>    <span class="at">flag_variables =</span> basket_vars,</span>
+<span id="cb16-178"><a href="#cb16-178"></a>    <span class="at">table_names =</span> <span class="st">"table_aesi"</span>,</span>
+<span id="cb16-179"><a href="#cb16-179"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-180"><a href="#cb16-180"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb16-181"><a href="#cb16-181"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-182"><a href="#cb16-182"></a>  )</span>
+<span id="cb16-183"><a href="#cb16-183"></a></span>
+<span id="cb16-184"><a href="#cb16-184"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-185"><a href="#cb16-185"></a></span>
+<span id="cb16-186"><a href="#cb16-186"></a><span class="co"># Combine tables.</span></span>
+<span id="cb16-187"><a href="#cb16-187"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb16-188"><a href="#cb16-188"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb16-189"><a href="#cb16-189"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb16-190"><a href="#cb16-190"></a>  result_adsl,</span>
+<span id="cb16-191"><a href="#cb16-191"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb16-192"><a href="#cb16-192"></a>)</span>
+<span id="cb16-193"><a href="#cb16-193"></a></span>
+<span id="cb16-194"><a href="#cb16-194"></a>result</span>
+<span id="cb16-195"><a href="#cb16-195"></a><span class="in">```</span></span>
+<span id="cb16-196"><a href="#cb16-196"></a></span>
+<span id="cb16-197"><a href="#cb16-197"></a><span class="fu">## Table with &lt;br/&gt; Modified Rows</span></span>
+<span id="cb16-198"><a href="#cb16-198"></a></span>
+<span id="cb16-199"><a href="#cb16-199"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-200"><a href="#cb16-200"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"WD"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb16-201"><a href="#cb16-201"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb16-202"><a href="#cb16-202"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-203"><a href="#cb16-203"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-204"><a href="#cb16-204"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-205"><a href="#cb16-205"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-206"><a href="#cb16-206"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-207"><a href="#cb16-207"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-208"><a href="#cb16-208"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb16-209"><a href="#cb16-209"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-210"><a href="#cb16-210"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-211"><a href="#cb16-211"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-212"><a href="#cb16-212"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb16-213"><a href="#cb16-213"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-214"><a href="#cb16-214"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb16-215"><a href="#cb16-215"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb16-216"><a href="#cb16-216"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-217"><a href="#cb16-217"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-218"><a href="#cb16-218"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-219"><a href="#cb16-219"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"WITHDRAWAL BY SUBJECT"</span>),</span>
+<span id="cb16-220"><a href="#cb16-220"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-221"><a href="#cb16-221"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn informed consent"</span>),</span>
+<span id="cb16-222"><a href="#cb16-222"></a>    <span class="at">table_names =</span> <span class="st">"tot_dscsreas_wd"</span></span>
+<span id="cb16-223"><a href="#cb16-223"></a>  )</span>
+<span id="cb16-224"><a href="#cb16-224"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-225"><a href="#cb16-225"></a></span>
+<span id="cb16-226"><a href="#cb16-226"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb16-227"><a href="#cb16-227"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-228"><a href="#cb16-228"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-229"><a href="#cb16-229"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-230"><a href="#cb16-230"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-231"><a href="#cb16-231"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-232"><a href="#cb16-232"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-233"><a href="#cb16-233"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb16-234"><a href="#cb16-234"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb16-235"><a href="#cb16-235"></a>    ),</span>
+<span id="cb16-236"><a href="#cb16-236"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-237"><a href="#cb16-237"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-238"><a href="#cb16-238"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-239"><a href="#cb16-239"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-240"><a href="#cb16-240"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-241"><a href="#cb16-241"></a>    <span class="at">flag_variables =</span> aesi_vars,</span>
+<span id="cb16-242"><a href="#cb16-242"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-243"><a href="#cb16-243"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb16-244"><a href="#cb16-244"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-245"><a href="#cb16-245"></a>  )</span>
+<span id="cb16-246"><a href="#cb16-246"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-247"><a href="#cb16-247"></a></span>
+<span id="cb16-248"><a href="#cb16-248"></a><span class="co"># Combine tables.</span></span>
+<span id="cb16-249"><a href="#cb16-249"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb16-250"><a href="#cb16-250"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb16-251"><a href="#cb16-251"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb16-252"><a href="#cb16-252"></a>  result_adsl,</span>
+<span id="cb16-253"><a href="#cb16-253"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb16-254"><a href="#cb16-254"></a>)</span>
+<span id="cb16-255"><a href="#cb16-255"></a></span>
+<span id="cb16-256"><a href="#cb16-256"></a>result</span>
+<span id="cb16-257"><a href="#cb16-257"></a><span class="in">```</span></span>
+<span id="cb16-258"><a href="#cb16-258"></a></span>
+<span id="cb16-259"><a href="#cb16-259"></a><span class="fu">## Table with Rows Counting &lt;br/&gt; Events &amp; Additional Sections</span></span>
+<span id="cb16-260"><a href="#cb16-260"></a></span>
+<span id="cb16-261"><a href="#cb16-261"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-262"><a href="#cb16-262"></a>count_subj_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"FATAL"</span>, <span class="st">"SER"</span>, <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>)</span>
+<span id="cb16-263"><a href="#cb16-263"></a>count_term_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb16-264"><a href="#cb16-264"></a>count_ae_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"DSM"</span>, <span class="st">"REL"</span>, <span class="st">"CTC35"</span>, <span class="st">"CTC45"</span>)</span>
+<span id="cb16-265"><a href="#cb16-265"></a></span>
+<span id="cb16-266"><a href="#cb16-266"></a><span class="co"># Layout for variables from adsl dataset.</span></span>
+<span id="cb16-267"><a href="#cb16-267"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-268"><a href="#cb16-268"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-269"><a href="#cb16-269"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-270"><a href="#cb16-270"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-271"><a href="#cb16-271"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DTHFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-272"><a href="#cb16-272"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-273"><a href="#cb16-273"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>)</span>
+<span id="cb16-274"><a href="#cb16-274"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-275"><a href="#cb16-275"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-276"><a href="#cb16-276"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-277"><a href="#cb16-277"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"DCSREAS"</span> <span class="ot">=</span> <span class="st">"ADVERSE EVENT"</span>),</span>
+<span id="cb16-278"><a href="#cb16-278"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-279"><a href="#cb16-279"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients withdrawn from study due to an AE"</span>),</span>
+<span id="cb16-280"><a href="#cb16-280"></a>    <span class="at">table_names =</span> <span class="st">"tot_wd"</span></span>
+<span id="cb16-281"><a href="#cb16-281"></a>  )</span>
+<span id="cb16-282"><a href="#cb16-282"></a></span>
+<span id="cb16-283"><a href="#cb16-283"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-284"><a href="#cb16-284"></a></span>
+<span id="cb16-285"><a href="#cb16-285"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb16-286"><a href="#cb16-286"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-287"><a href="#cb16-287"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-288"><a href="#cb16-288"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-289"><a href="#cb16-289"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-290"><a href="#cb16-290"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-291"><a href="#cb16-291"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-292"><a href="#cb16-292"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one AE"</span>,</span>
+<span id="cb16-293"><a href="#cb16-293"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of AEs"</span></span>
+<span id="cb16-294"><a href="#cb16-294"></a>    ),</span>
+<span id="cb16-295"><a href="#cb16-295"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="at">unique =</span> format_count_fraction_fixed_dp, <span class="at">nonunique =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-296"><a href="#cb16-296"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-297"><a href="#cb16-297"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-298"><a href="#cb16-298"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-299"><a href="#cb16-299"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-300"><a href="#cb16-300"></a>    <span class="at">flag_variables =</span> count_subj_vars,</span>
+<span id="cb16-301"><a href="#cb16-301"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-302"><a href="#cb16-302"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one"</span>,</span>
+<span id="cb16-303"><a href="#cb16-303"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-304"><a href="#cb16-304"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-305"><a href="#cb16-305"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-306"><a href="#cb16-306"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb16-307"><a href="#cb16-307"></a>    <span class="at">flag_variables =</span> count_term_vars,</span>
+<span id="cb16-308"><a href="#cb16-308"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-309"><a href="#cb16-309"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-310"><a href="#cb16-310"></a>    <span class="at">table_names =</span> <span class="st">"table_term"</span>,</span>
+<span id="cb16-311"><a href="#cb16-311"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of unique preferred terms which are"</span>,</span>
+<span id="cb16-312"><a href="#cb16-312"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-313"><a href="#cb16-313"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-314"><a href="#cb16-314"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-315"><a href="#cb16-315"></a>    <span class="st">"USUBJID_AESEQ"</span>,</span>
+<span id="cb16-316"><a href="#cb16-316"></a>    <span class="at">flag_variables =</span> count_ae_vars,</span>
+<span id="cb16-317"><a href="#cb16-317"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-318"><a href="#cb16-318"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"xx"</span>),</span>
+<span id="cb16-319"><a href="#cb16-319"></a>    <span class="at">table_names =</span> <span class="st">"table_ae"</span>,</span>
+<span id="cb16-320"><a href="#cb16-320"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of adverse events which are"</span>,</span>
+<span id="cb16-321"><a href="#cb16-321"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-322"><a href="#cb16-322"></a>  )</span>
+<span id="cb16-323"><a href="#cb16-323"></a></span>
+<span id="cb16-324"><a href="#cb16-324"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-325"><a href="#cb16-325"></a></span>
+<span id="cb16-326"><a href="#cb16-326"></a><span class="co"># Combine tables.</span></span>
+<span id="cb16-327"><a href="#cb16-327"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb16-328"><a href="#cb16-328"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb16-329"><a href="#cb16-329"></a>  result_adae[<span class="dv">1</span><span class="sc">:</span><span class="dv">2</span>, ],</span>
+<span id="cb16-330"><a href="#cb16-330"></a>  result_adsl,</span>
+<span id="cb16-331"><a href="#cb16-331"></a>  result_adae[<span class="dv">3</span><span class="sc">:</span><span class="fu">nrow</span>(result_adae), ]</span>
+<span id="cb16-332"><a href="#cb16-332"></a>)</span>
+<span id="cb16-333"><a href="#cb16-333"></a></span>
+<span id="cb16-334"><a href="#cb16-334"></a>result</span>
+<span id="cb16-335"><a href="#cb16-335"></a><span class="in">```</span></span>
+<span id="cb16-336"><a href="#cb16-336"></a></span>
+<span id="cb16-337"><a href="#cb16-337"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-338"><a href="#cb16-338"></a></span>
+<span id="cb16-339"><a href="#cb16-339"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-340"><a href="#cb16-340"></a></span>
+<span id="cb16-341"><a href="#cb16-341"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-342"><a href="#cb16-342"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb16-343"><a href="#cb16-343"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-344"><a href="#cb16-344"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-345"><a href="#cb16-345"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-346"><a href="#cb16-346"></a></span>
+<span id="cb16-347"><a href="#cb16-347"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-348"><a href="#cb16-348"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-349"><a href="#cb16-349"></a></span>
+<span id="cb16-350"><a href="#cb16-350"></a>add_event_flags <span class="ot">&lt;-</span> <span class="cf">function</span>(dat) {</span>
+<span id="cb16-351"><a href="#cb16-351"></a>  dat <span class="sc">%&gt;%</span></span>
+<span id="cb16-352"><a href="#cb16-352"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb16-353"><a href="#cb16-353"></a>      <span class="at">TMPFL_SER =</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-354"><a href="#cb16-354"></a>      <span class="at">TMPFL_REL =</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-355"><a href="#cb16-355"></a>      <span class="at">TMPFL_GR5 =</span> AETOXGR <span class="sc">==</span> <span class="st">"5"</span>,</span>
+<span id="cb16-356"><a href="#cb16-356"></a>      <span class="at">TMP_SMQ01 =</span> <span class="sc">!</span><span class="fu">is.na</span>(SMQ01NAM),</span>
+<span id="cb16-357"><a href="#cb16-357"></a>      <span class="at">TMP_SMQ02 =</span> <span class="sc">!</span><span class="fu">is.na</span>(SMQ02NAM),</span>
+<span id="cb16-358"><a href="#cb16-358"></a>      <span class="at">TMP_CQ01 =</span> <span class="sc">!</span><span class="fu">is.na</span>(CQ01NAM)</span>
+<span id="cb16-359"><a href="#cb16-359"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-360"><a href="#cb16-360"></a>    <span class="fu">var_relabel</span>(</span>
+<span id="cb16-361"><a href="#cb16-361"></a>      <span class="at">TMPFL_SER =</span> <span class="st">"Serious AE"</span>,</span>
+<span id="cb16-362"><a href="#cb16-362"></a>      <span class="at">TMPFL_REL =</span> <span class="st">"Related AE"</span>,</span>
+<span id="cb16-363"><a href="#cb16-363"></a>      <span class="at">TMPFL_GR5 =</span> <span class="st">"Grade 5 AE"</span>,</span>
+<span id="cb16-364"><a href="#cb16-364"></a>      <span class="at">TMP_SMQ01 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"SMQ01NAM"</span>]], dat[[<span class="st">"SMQ01SC"</span>]]),</span>
+<span id="cb16-365"><a href="#cb16-365"></a>      <span class="at">TMP_SMQ02 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"SMQ02NAM"</span>]], dat[[<span class="st">"SMQ02SC"</span>]]),</span>
+<span id="cb16-366"><a href="#cb16-366"></a>      <span class="at">TMP_CQ01 =</span> <span class="fu">aesi_label</span>(dat[[<span class="st">"CQ01NAM"</span>]])</span>
+<span id="cb16-367"><a href="#cb16-367"></a>    )</span>
+<span id="cb16-368"><a href="#cb16-368"></a>}</span>
+<span id="cb16-369"><a href="#cb16-369"></a></span>
+<span id="cb16-370"><a href="#cb16-370"></a><span class="co"># Generating user-defined event flags.</span></span>
+<span id="cb16-371"><a href="#cb16-371"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">add_event_flags</span>()</span>
+<span id="cb16-372"><a href="#cb16-372"></a></span>
+<span id="cb16-373"><a href="#cb16-373"></a>ae_anl_vars <span class="ot">&lt;-</span> <span class="fu">names</span>(adae)[<span class="fu">startsWith</span>(<span class="fu">names</span>(adae), <span class="st">"TMPFL_"</span>)]</span>
+<span id="cb16-374"><a href="#cb16-374"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">names</span>(adae)[<span class="fu">startsWith</span>(<span class="fu">names</span>(adae), <span class="st">"TMP_"</span>)]</span>
+<span id="cb16-375"><a href="#cb16-375"></a></span>
+<span id="cb16-376"><a href="#cb16-376"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-377"><a href="#cb16-377"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-378"><a href="#cb16-378"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb16-379"><a href="#cb16-379"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")</span></span>
+<span id="cb16-380"><a href="#cb16-380"></a><span class="st">      add_event_flags &lt;- function(dat) {</span></span>
+<span id="cb16-381"><a href="#cb16-381"></a><span class="st">        dat %&gt;%</span></span>
+<span id="cb16-382"><a href="#cb16-382"></a><span class="st">          dplyr::mutate(</span></span>
+<span id="cb16-383"><a href="#cb16-383"></a><span class="st">            TMPFL_SER = AESER == "Y",</span></span>
+<span id="cb16-384"><a href="#cb16-384"></a><span class="st">            TMPFL_REL = AEREL == "Y",</span></span>
+<span id="cb16-385"><a href="#cb16-385"></a><span class="st">            TMPFL_GR5 = AETOXGR == "5",</span></span>
+<span id="cb16-386"><a href="#cb16-386"></a><span class="st">            TMP_SMQ01 = !is.na(SMQ01NAM),</span></span>
+<span id="cb16-387"><a href="#cb16-387"></a><span class="st">            TMP_SMQ02 = !is.na(SMQ02NAM),</span></span>
+<span id="cb16-388"><a href="#cb16-388"></a><span class="st">            TMP_CQ01 = !is.na(CQ01NAM)</span></span>
+<span id="cb16-389"><a href="#cb16-389"></a><span class="st">          ) %&gt;%</span></span>
+<span id="cb16-390"><a href="#cb16-390"></a><span class="st">          var_relabel(</span></span>
+<span id="cb16-391"><a href="#cb16-391"></a><span class="st">            TMPFL_SER = "Serious AE",</span></span>
+<span id="cb16-392"><a href="#cb16-392"></a><span class="st">            TMPFL_REL = "Related AE",</span></span>
+<span id="cb16-393"><a href="#cb16-393"></a><span class="st">            TMPFL_GR5 = "Grade 5 AE",</span></span>
+<span id="cb16-394"><a href="#cb16-394"></a><span class="st">            TMP_SMQ01 = aesi_label(dat[["SMQ01NAM"]], dat[["SMQ01SC"]]),</span></span>
+<span id="cb16-395"><a href="#cb16-395"></a><span class="st">            TMP_SMQ02 = aesi_label(dat[["SMQ02NAM"]], dat[["SMQ02SC"]]),</span></span>
+<span id="cb16-396"><a href="#cb16-396"></a><span class="st">            TMP_CQ01 = aesi_label(dat[["CQ01NAM"]])</span></span>
+<span id="cb16-397"><a href="#cb16-397"></a><span class="st">          )</span></span>
+<span id="cb16-398"><a href="#cb16-398"></a><span class="st">      }</span></span>
+<span id="cb16-399"><a href="#cb16-399"></a><span class="st">      ADAE &lt;- ADAE %&gt;% add_event_flags()'</span>),</span>
+<span id="cb16-400"><a href="#cb16-400"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-401"><a href="#cb16-401"></a>  ),</span>
+<span id="cb16-402"><a href="#cb16-402"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-403"><a href="#cb16-403"></a>    <span class="fu">tm_t_events_summary</span>(</span>
+<span id="cb16-404"><a href="#cb16-404"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Summary"</span>,</span>
+<span id="cb16-405"><a href="#cb16-405"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb16-406"><a href="#cb16-406"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-407"><a href="#cb16-407"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADSL"</span>, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb16-408"><a href="#cb16-408"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb16-409"><a href="#cb16-409"></a>      ),</span>
+<span id="cb16-410"><a href="#cb16-410"></a>      <span class="at">flag_var_anl =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-411"><a href="#cb16-411"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, ae_anl_vars),</span>
+<span id="cb16-412"><a href="#cb16-412"></a>        <span class="at">selected =</span> ae_anl_vars[<span class="dv">1</span>],</span>
+<span id="cb16-413"><a href="#cb16-413"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-414"><a href="#cb16-414"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb16-415"><a href="#cb16-415"></a>      ),</span>
+<span id="cb16-416"><a href="#cb16-416"></a>      <span class="at">flag_var_aesi =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-417"><a href="#cb16-417"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, aesi_vars),</span>
+<span id="cb16-418"><a href="#cb16-418"></a>        <span class="at">selected =</span> aesi_vars[<span class="dv">1</span>],</span>
+<span id="cb16-419"><a href="#cb16-419"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-420"><a href="#cb16-420"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb16-421"><a href="#cb16-421"></a>      ),</span>
+<span id="cb16-422"><a href="#cb16-422"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-423"><a href="#cb16-423"></a>    )</span>
+<span id="cb16-424"><a href="#cb16-424"></a>  )</span>
+<span id="cb16-425"><a href="#cb16-425"></a>)</span>
+<span id="cb16-426"><a href="#cb16-426"></a></span>
+<span id="cb16-427"><a href="#cb16-427"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-428"><a href="#cb16-428"></a><span class="in">```</span></span>
+<span id="cb16-429"><a href="#cb16-429"></a></span>
+<span id="cb16-430"><a href="#cb16-430"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-431"><a href="#cb16-431"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/tables/adverse-events/aet01_aesi.html b/stable/tables/adverse-events/aet01_aesi.html
new file mode 100644
index 0000000000..3cfb16331a
--- /dev/null
+++ b/stable/tables/adverse-events/aet01_aesi.html
@@ -0,0 +1,3330 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET01_AESI</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">Disposition</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET01_AESI</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Safety Summary (Adverse Events of Special Interest)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with <br> Optional Lines</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table For Studies <br> with Multiple Drugs</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table of AEs <br> by SMQ</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>To illustrate, additional variables such as flags (TRUE/FALSE) for selected AEs of interest. Please consult your SAP on how to handle missing AE grades.</p>
+<div class="cell" data-hash="aet01_aesi_cache/html/setup_5354ac2c0fafb67583ca90d66ba8b2c0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>not_resolved <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one unresolved or ongoing non-fatal AE"</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  )</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug withdrawn due to AE"</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Total number of patients with dose modified/interrupted due to AE"</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>    ),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one related AE"</span>),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to resolved AE"</span>),</span>
+<span id="cb1-37"><a href="#cb1-37"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to resolved AE"</span>),</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to unresolved or ongoing AE"</span>),</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to serious AE"</span>),</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with dose modified/interrupted due to serious AE"</span>),</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-45"><a href="#cb1-45"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"No. of patients with treatment received for serious AE"</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>    ),</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to related AE"</span>),</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb1-50"><a href="#cb1-50"></a>      <span class="st">"No. of patients with dose modified/interrupted due to related AE"</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>    ),</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for related AE"</span>),</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious, related AE"</span>)</span>
+<span id="cb1-54"><a href="#cb1-54"></a>  )</span>
+<span id="cb1-55"><a href="#cb1-55"></a></span>
+<span id="cb1-56"><a href="#cb1-56"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    <span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(AETOXGR,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>      <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>    )</span>
+<span id="cb1-65"><a href="#cb1-65"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet01_aesi_cache/html/variant1_7e6669d6530744514fb760a932c93da9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED"</span>, <span class="st">"NOT_RESOLVED"</span>, <span class="st">"SER"</span>, <span class="st">"REL"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">count_patients_with_flags</span>(<span class="st">"USUBJID"</span>, <span class="at">flag_variables =</span> aesi_vars, <span class="at">denom =</span> <span class="st">"N_col"</span>)</span>
+<span id="cb2-24"><a href="#cb2-24"></a></span>
+<span id="cb2-25"><a href="#cb2-25"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-26"><a href="#cb2-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                                 A: Drug X    B: Placebo   C: Combination
+                                                                                  (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                                   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                                                 502          480            604      
+Total number of patients with at least one AE by worst grade                                                             
+  Grade 1                                                                        5 (3.7%)      7 (5.2%)       4 (3.0%)   
+  Grade 2                                                                        5 (3.7%)      8 (6.0%)       6 (4.5%)   
+  Grade 3                                                                        13 (9.7%)    13 (9.7%)      14 (10.6%)  
+  Grade 4                                                                        13 (9.7%)    18 (13.4%)     15 (11.4%)  
+  Grade 5 (fatal outcome)                                                       64 (47.8%)    52 (38.8%)     64 (48.5%)  
+Total number of patients with study drug withdrawn due to AE                    22 (16.4%)    21 (15.7%)     28 (21.2%)  
+Total number of patients with dose modified/interrupted due to AE               55 (41.0%)    62 (46.3%)     64 (48.5%)  
+Total number of patients with treatment received for AE                         80 (59.7%)    80 (59.7%)     89 (67.4%)  
+Total number of patients with all non-fatal AEs resolved                        17 (12.7%)    12 (9.0%)      11 (8.3%)   
+Total number of patients with at least one unresolved or ongoing non-fatal AE   83 (61.9%)    86 (64.2%)     92 (69.7%)  
+Total number of patients with at least one serious AE                           85 (63.4%)    80 (59.7%)     87 (65.9%)  
+Total number of patients with at least one related AE                           86 (64.2%)    85 (63.4%)     92 (69.7%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet01_aesi_cache/html/variant2_a8b1367c8b84bda447b61f6425fa0608">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a>aesi_resolved <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ALL_RESOLVED"</span>, <span class="st">"ALL_RESOLVED_WD"</span>, <span class="st">"ALL_RESOLVED_DSM"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>)</span>
+<span id="cb4-3"><a href="#cb4-3"></a>aesi_not_resolved <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"NOT_RESOLVED"</span>, <span class="st">"NOT_RESOLVED_WD"</span>, <span class="st">"NOT_RESOLVED_DSM"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>)</span>
+<span id="cb4-4"><a href="#cb4-4"></a>aesi_ser <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"SERCONTRT"</span>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>aesi_rel <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"RELCONTRT"</span>, <span class="st">"RELSER"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb4-14"><a href="#cb4-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(aesi_vars, aesi_resolved[<span class="dv">1</span>]), <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">flag_variables =</span> aesi_resolved[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_res"</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="at">flag_variables =</span> aesi_not_resolved[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_notres_main"</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">flag_variables =</span> aesi_not_resolved[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_notres"</span></span>
+<span id="cb4-42"><a href="#cb4-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-44"><a href="#cb4-44"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_ser_main"</span></span>
+<span id="cb4-46"><a href="#cb4-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-48"><a href="#cb4-48"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-49"><a href="#cb4-49"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb4-50"><a href="#cb4-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-52"><a href="#cb4-52"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>    <span class="at">flag_variables =</span> aesi_rel[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel_main"</span></span>
+<span id="cb4-54"><a href="#cb4-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-56"><a href="#cb4-56"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-57"><a href="#cb4-57"></a>    <span class="at">flag_variables =</span> aesi_rel[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel"</span></span>
+<span id="cb4-58"><a href="#cb4-58"></a>  )</span>
+<span id="cb4-59"><a href="#cb4-59"></a></span>
+<span id="cb4-60"><a href="#cb4-60"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-61"><a href="#cb4-61"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                                    A: Drug X    B: Placebo   C: Combination
+                                                                                     (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                                      100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                                                    502          480            604      
+Total number of patients with at least one AE by worst grade                                                                
+  Grade 1                                                                           5 (3.7%)      7 (5.2%)       4 (3.0%)   
+  Grade 2                                                                           5 (3.7%)      8 (6.0%)       6 (4.5%)   
+  Grade 3                                                                           13 (9.7%)    13 (9.7%)      14 (10.6%)  
+  Grade 4                                                                           13 (9.7%)    18 (13.4%)     15 (11.4%)  
+  Grade 5 (fatal outcome)                                                          64 (47.8%)    52 (38.8%)     64 (48.5%)  
+Total number of patients with study drug withdrawn due to AE                       22 (16.4%)    21 (15.7%)     28 (21.2%)  
+Total number of patients with dose modified/interrupted due to AE                  55 (41.0%)    62 (46.3%)     64 (48.5%)  
+Total number of patients with treatment received for AE                            80 (59.7%)    80 (59.7%)     89 (67.4%)  
+Total number of patients with all non-fatal AEs resolved                           17 (12.7%)    12 (9.0%)      11 (8.3%)   
+  No. of patients with study drug withdrawn due to resolved AE                          0         1 (0.7%)       2 (1.5%)   
+  No. of patients with dose modified/interrupted due to resolved AE                 3 (2.2%)      4 (3.0%)       2 (1.5%)   
+  No. of patients with treatment received for resolved AE                           9 (6.7%)      7 (5.2%)       7 (5.3%)   
+Total number of patients with at least one unresolved or ongoing non-fatal AE      83 (61.9%)    86 (64.2%)     92 (69.7%)  
+  No. of patients with study drug withdrawn due to unresolved or ongoing AE        22 (16.4%)    20 (14.9%)     26 (19.7%)  
+  No. of patients with dose modified/interrupted due to unresolved or ongoing AE   52 (38.8%)    58 (43.3%)     62 (47.0%)  
+  No. of patients with treatment received for unresolved or ongoing AE             71 (53.0%)    73 (54.5%)     82 (62.1%)  
+Total number of patients with at least one serious AE                              85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  No. of patients with study drug withdrawn due to serious AE                       9 (6.7%)      4 (3.0%)      10 (7.6%)   
+  No. of patients with treatment received for serious AE                           21 (15.7%)    22 (16.4%)     28 (21.2%)  
+  No. of patients with dose modified/interrupted due to serious AE                 59 (44.0%)    58 (43.3%)     53 (40.2%)  
+Total number of patients with at least one related AE                              86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  No. of patients with study drug withdrawn due to related AE                       5 (3.7%)     10 (7.5%)       7 (5.3%)   
+  No. of patients with dose modified/interrupted due to related AE                 24 (17.9%)    32 (23.9%)     34 (25.8%)  
+  No. of patients with treatment received for related AE                           53 (39.6%)    58 (43.3%)     60 (45.5%)  
+  No. of patients with serious, related AE                                         64 (47.8%)    52 (38.8%)     64 (48.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet01_aesi_cache/html/variant3_1cbaf22e3f39df634eeb70da395ad52e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-3"><a href="#cb6-3"></a></span>
+<span id="cb6-4"><a href="#cb6-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-5"><a href="#cb6-5"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae_mult, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a></span>
+<span id="cb6-7"><a href="#cb6-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-8"><a href="#cb6-8"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae_mult)</span>
+<span id="cb6-9"><a href="#cb6-9"></a></span>
+<span id="cb6-10"><a href="#cb6-10"></a><span class="co"># for illustration purposes only, create AEREL1, AEREL2, AEACN1, AEACN2 from respective variables</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">AEREL1 =</span> AEREL,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">AEREL2 =</span> AEREL,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">AEACN1 =</span> AEACN,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">AEACN2 =</span> AEACN</span>
+<span id="cb6-17"><a href="#cb6-17"></a>  )</span>
+<span id="cb6-18"><a href="#cb6-18"></a></span>
+<span id="cb6-19"><a href="#cb6-19"></a>not_resolved <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-23"><a href="#cb6-23"></a></span>
+<span id="cb6-24"><a href="#cb6-24"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb6-29"><a href="#cb6-29"></a>  )</span>
+<span id="cb6-30"><a href="#cb6-30"></a></span>
+<span id="cb6-31"><a href="#cb6-31"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="at">WD1 =</span> <span class="fu">with_label</span>(AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug 1 withdrawn due to AE"</span>),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">WD2 =</span> <span class="fu">with_label</span>(AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug 2 withdrawn due to AE"</span>),</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="at">DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-37"><a href="#cb6-37"></a>      AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-38"><a href="#cb6-38"></a>      <span class="st">"Total number of patients with dose of study drug 1 modified/interrupted due to AE"</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>    ),</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="at">DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-41"><a href="#cb6-41"></a>      AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-42"><a href="#cb6-42"></a>      <span class="st">"Total number of patients with dose of study drug 2 modified/interrupted due to AE"</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a>    ),</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">REL1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one AE related to study drug 1"</span>),</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="at">REL2 =</span> <span class="fu">with_label</span>(AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one AE related to study drug 2"</span>),</span>
+<span id="cb6-48"><a href="#cb6-48"></a>    <span class="at">ALL_RESOLVED_WD1 =</span> <span class="fu">with_label</span>(WD1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to resolved AE"</span>),</span>
+<span id="cb6-49"><a href="#cb6-49"></a>    <span class="at">ALL_RESOLVED_DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-50"><a href="#cb6-50"></a>      DSM1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to resolved AE"</span></span>
+<span id="cb6-51"><a href="#cb6-51"></a>    ),</span>
+<span id="cb6-52"><a href="#cb6-52"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb6-53"><a href="#cb6-53"></a>    <span class="at">ALL_RESOLVED_WD2 =</span> <span class="fu">with_label</span>(WD2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to resolved AE"</span>),</span>
+<span id="cb6-54"><a href="#cb6-54"></a>    <span class="at">ALL_RESOLVED_DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-55"><a href="#cb6-55"></a>      DSM2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to resolved AE"</span></span>
+<span id="cb6-56"><a href="#cb6-56"></a>    ),</span>
+<span id="cb6-57"><a href="#cb6-57"></a>    <span class="at">NOT_RESOLVED_WD1 =</span> <span class="fu">with_label</span>(WD1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb6-58"><a href="#cb6-58"></a>    <span class="at">NOT_RESOLVED_DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-59"><a href="#cb6-59"></a>      DSM1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to unresolved or ongoing AE"</span></span>
+<span id="cb6-60"><a href="#cb6-60"></a>    ),</span>
+<span id="cb6-61"><a href="#cb6-61"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb6-62"><a href="#cb6-62"></a>    <span class="at">NOT_RESOLVED_WD2 =</span> <span class="fu">with_label</span>(WD2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb6-63"><a href="#cb6-63"></a>    <span class="at">NOT_RESOLVED_DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-64"><a href="#cb6-64"></a>      DSM2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to unresolved or ongoing AE"</span></span>
+<span id="cb6-65"><a href="#cb6-65"></a>    ),</span>
+<span id="cb6-66"><a href="#cb6-66"></a>    <span class="at">SERWD1 =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to serious AE"</span>),</span>
+<span id="cb6-67"><a href="#cb6-67"></a>    <span class="at">SERWD2 =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to serious AE"</span>),</span>
+<span id="cb6-68"><a href="#cb6-68"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for serious AE"</span>),</span>
+<span id="cb6-69"><a href="#cb6-69"></a>    <span class="at">SERDSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-70"><a href="#cb6-70"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-71"><a href="#cb6-71"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to serious AE"</span></span>
+<span id="cb6-72"><a href="#cb6-72"></a>    ),</span>
+<span id="cb6-73"><a href="#cb6-73"></a>    <span class="at">SERDSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-74"><a href="#cb6-74"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-75"><a href="#cb6-75"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to serious AE"</span></span>
+<span id="cb6-76"><a href="#cb6-76"></a>    ),</span>
+<span id="cb6-77"><a href="#cb6-77"></a>    <span class="at">REL1WD1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to AE related to study drug 1"</span>),</span>
+<span id="cb6-78"><a href="#cb6-78"></a>    <span class="at">REL1WD2 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to AE related to study drug 2"</span>),</span>
+<span id="cb6-79"><a href="#cb6-79"></a>    <span class="at">REL2WD1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to AE related to study drug 1"</span>),</span>
+<span id="cb6-80"><a href="#cb6-80"></a>    <span class="at">REL2WD2 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to AE related to study drug 2"</span>),</span>
+<span id="cb6-81"><a href="#cb6-81"></a>    <span class="at">REL1DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-82"><a href="#cb6-82"></a>      AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-83"><a href="#cb6-83"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 1"</span></span>
+<span id="cb6-84"><a href="#cb6-84"></a>    ),</span>
+<span id="cb6-85"><a href="#cb6-85"></a>    <span class="at">REL2DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-86"><a href="#cb6-86"></a>      AEREL2 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-87"><a href="#cb6-87"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 1"</span></span>
+<span id="cb6-88"><a href="#cb6-88"></a>    ),</span>
+<span id="cb6-89"><a href="#cb6-89"></a>    <span class="at">REL1DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-90"><a href="#cb6-90"></a>      AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-91"><a href="#cb6-91"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 2"</span></span>
+<span id="cb6-92"><a href="#cb6-92"></a>    ),</span>
+<span id="cb6-93"><a href="#cb6-93"></a>    <span class="at">REL2DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb6-94"><a href="#cb6-94"></a>      AEREL2 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb6-95"><a href="#cb6-95"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 2"</span></span>
+<span id="cb6-96"><a href="#cb6-96"></a>    ),</span>
+<span id="cb6-97"><a href="#cb6-97"></a>    <span class="at">REL1CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for AE related to study drug 1"</span>),</span>
+<span id="cb6-98"><a href="#cb6-98"></a>    <span class="at">REL2CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for AE related to study drug 2"</span>),</span>
+<span id="cb6-99"><a href="#cb6-99"></a>    <span class="at">REL1SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious AE related to study drug 1"</span>),</span>
+<span id="cb6-100"><a href="#cb6-100"></a>    <span class="at">REL2SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious AE related to study drug 2"</span>)</span>
+<span id="cb6-101"><a href="#cb6-101"></a>  )</span>
+<span id="cb6-102"><a href="#cb6-102"></a></span>
+<span id="cb6-103"><a href="#cb6-103"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb6-104"><a href="#cb6-104"></a>  <span class="fu">mutate</span>(<span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb6-105"><a href="#cb6-105"></a>    AETOXGR,</span>
+<span id="cb6-106"><a href="#cb6-106"></a>    <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb6-107"><a href="#cb6-107"></a>    <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb6-108"><a href="#cb6-108"></a>    <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb6-109"><a href="#cb6-109"></a>    <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb6-110"><a href="#cb6-110"></a>    <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb6-111"><a href="#cb6-111"></a>  ))</span>
+<span id="cb6-112"><a href="#cb6-112"></a></span>
+<span id="cb6-113"><a href="#cb6-113"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD1"</span>, <span class="st">"WD2"</span>, <span class="st">"DSM1"</span>, <span class="st">"DSM2"</span>, <span class="st">"CONTRT"</span>)</span>
+<span id="cb6-114"><a href="#cb6-114"></a>aesi_res <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ALL_RESOLVED"</span>, <span class="st">"ALL_RESOLVED_WD1"</span>, <span class="st">"ALL_RESOLVED_WD2"</span>, <span class="st">"ALL_RESOLVED_DSM1"</span>, <span class="st">"ALL_RESOLVED_DSM2"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>)</span>
+<span id="cb6-115"><a href="#cb6-115"></a>aesi_not_res <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"NOT_RESOLVED"</span>, <span class="st">"NOT_RESOLVED_WD1"</span>, <span class="st">"NOT_RESOLVED_WD2"</span>, <span class="st">"NOT_RESOLVED_DSM1"</span>, <span class="st">"NOT_RESOLVED_DSM2"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>)</span>
+<span id="cb6-116"><a href="#cb6-116"></a>aesi_ser <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"SERWD1"</span>, <span class="st">"SERWD2"</span>, <span class="st">"SERDSM1"</span>, <span class="st">"SERDSM2"</span>, <span class="st">"SERCONTRT"</span>)</span>
+<span id="cb6-117"><a href="#cb6-117"></a>aesi_rel1 <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL1"</span>, <span class="st">"REL1WD1"</span>, <span class="st">"REL1WD2"</span>, <span class="st">"REL1DSM1"</span>, <span class="st">"REL1DSM2"</span>, <span class="st">"REL1CONTRT"</span>, <span class="st">"REL1SER"</span>)</span>
+<span id="cb6-118"><a href="#cb6-118"></a>aesi_rel2 <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL2"</span>, <span class="st">"REL2WD1"</span>, <span class="st">"REL2WD2"</span>, <span class="st">"REL2DSM1"</span>, <span class="st">"REL2DSM2"</span>, <span class="st">"REL2CONTRT"</span>, <span class="st">"REL2SER"</span>)</span>
+<span id="cb6-119"><a href="#cb6-119"></a></span>
+<span id="cb6-120"><a href="#cb6-120"></a>lyt_adae_mult <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-121"><a href="#cb6-121"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-122"><a href="#cb6-122"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb6-123"><a href="#cb6-123"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-124"><a href="#cb6-124"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb6-125"><a href="#cb6-125"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb6-126"><a href="#cb6-126"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb6-127"><a href="#cb6-127"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-128"><a href="#cb6-128"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-129"><a href="#cb6-129"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb6-130"><a href="#cb6-130"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb6-131"><a href="#cb6-131"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb6-132"><a href="#cb6-132"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb6-133"><a href="#cb6-133"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb6-134"><a href="#cb6-134"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-135"><a href="#cb6-135"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb6-136"><a href="#cb6-136"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb6-137"><a href="#cb6-137"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb6-138"><a href="#cb6-138"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb6-139"><a href="#cb6-139"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-140"><a href="#cb6-140"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-141"><a href="#cb6-141"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-142"><a href="#cb6-142"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(aesi_vars, aesi_res[<span class="dv">1</span>]), <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb6-143"><a href="#cb6-143"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-144"><a href="#cb6-144"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-145"><a href="#cb6-145"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-146"><a href="#cb6-146"></a>    <span class="at">flag_variables =</span> aesi_res[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_res"</span></span>
+<span id="cb6-147"><a href="#cb6-147"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-148"><a href="#cb6-148"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-149"><a href="#cb6-149"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-150"><a href="#cb6-150"></a>    <span class="at">flag_variables =</span> aesi_not_res[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_notres_main"</span></span>
+<span id="cb6-151"><a href="#cb6-151"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-152"><a href="#cb6-152"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-153"><a href="#cb6-153"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-154"><a href="#cb6-154"></a>    <span class="at">flag_variables =</span> aesi_not_res[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_notres"</span></span>
+<span id="cb6-155"><a href="#cb6-155"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-156"><a href="#cb6-156"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-157"><a href="#cb6-157"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-158"><a href="#cb6-158"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_ser_main"</span></span>
+<span id="cb6-159"><a href="#cb6-159"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-160"><a href="#cb6-160"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-161"><a href="#cb6-161"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-162"><a href="#cb6-162"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb6-163"><a href="#cb6-163"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-164"><a href="#cb6-164"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-165"><a href="#cb6-165"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-166"><a href="#cb6-166"></a>    <span class="at">flag_variables =</span> aesi_rel1[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel1_main"</span></span>
+<span id="cb6-167"><a href="#cb6-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-168"><a href="#cb6-168"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-169"><a href="#cb6-169"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-170"><a href="#cb6-170"></a>    <span class="at">flag_variables =</span> aesi_rel1[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel1"</span></span>
+<span id="cb6-171"><a href="#cb6-171"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-172"><a href="#cb6-172"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-173"><a href="#cb6-173"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-174"><a href="#cb6-174"></a>    <span class="at">flag_variables =</span> aesi_rel2[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel2_main"</span></span>
+<span id="cb6-175"><a href="#cb6-175"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-176"><a href="#cb6-176"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-177"><a href="#cb6-177"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-178"><a href="#cb6-178"></a>    <span class="at">flag_variables =</span> aesi_rel2[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel2"</span></span>
+<span id="cb6-179"><a href="#cb6-179"></a>  )</span>
+<span id="cb6-180"><a href="#cb6-180"></a></span>
+<span id="cb6-181"><a href="#cb6-181"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae_mult, <span class="at">df =</span> adae_mult, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb6-182"><a href="#cb6-182"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                                                      A: Drug X    B: Placebo   C: Combination
+                                                                                                       (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one AE                                                        100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of AEs                                                                                      502          480            604      
+Total number of patients with at least one AE by worst grade                                                                                  
+  Grade 1                                                                                             5 (3.7%)      7 (5.2%)       4 (3.0%)   
+  Grade 2                                                                                             5 (3.7%)      8 (6.0%)       6 (4.5%)   
+  Grade 3                                                                                             13 (9.7%)    13 (9.7%)      14 (10.6%)  
+  Grade 4                                                                                             13 (9.7%)    18 (13.4%)     15 (11.4%)  
+  Grade 5 (fatal outcome)                                                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  
+Total number of patients with study drug 1 withdrawn due to AE                                       22 (16.4%)    21 (15.7%)     28 (21.2%)  
+Total number of patients with study drug 2 withdrawn due to AE                                       22 (16.4%)    21 (15.7%)     28 (21.2%)  
+Total number of patients with dose of study drug 1 modified/interrupted due to AE                    55 (41.0%)    62 (46.3%)     64 (48.5%)  
+Total number of patients with dose of study drug 2 modified/interrupted due to AE                    55 (41.0%)    62 (46.3%)     64 (48.5%)  
+Total number of patients with treatment received for AE                                              80 (59.7%)    80 (59.7%)     89 (67.4%)  
+Total number of patients with all non-fatal AEs resolved                                             17 (12.7%)    12 (9.0%)      11 (8.3%)   
+  No. of patients with study drug 1 withdrawn due to resolved AE                                          0         1 (0.7%)       2 (1.5%)   
+  No. of patients with study drug 2 withdrawn due to resolved AE                                          0         1 (0.7%)       2 (1.5%)   
+  No. of patients with dose of study drug 1 modified/interrupted due to resolved AE                   3 (2.2%)      4 (3.0%)       2 (1.5%)   
+  No. of patients with dose of study drug 2 modified/interrupted due to resolved AE                   3 (2.2%)      4 (3.0%)       2 (1.5%)   
+  No. of patients with treatment received for resolved AE                                             9 (6.7%)      7 (5.2%)       7 (5.3%)   
+Total number of patients with at least one non-fatal unresolved or ongoing AE                        83 (61.9%)    86 (64.2%)     92 (69.7%)  
+  No. of patients with study drug 1 withdrawn due to unresolved or ongoing AE                        22 (16.4%)    20 (14.9%)     26 (19.7%)  
+  No. of patients with study drug 2 withdrawn due to unresolved or ongoing AE                        22 (16.4%)    20 (14.9%)     26 (19.7%)  
+  No. of patients with dose of study drug 1 modified/interrupted due to unresolved or ongoing AE     52 (38.8%)    58 (43.3%)     62 (47.0%)  
+  No. of patients with dose of study drug 2 modified/interrupted due to unresolved or ongoing AE     52 (38.8%)    58 (43.3%)     62 (47.0%)  
+  No. of patients with treatment received for unresolved or ongoing AE                               71 (53.0%)    73 (54.5%)     82 (62.1%)  
+Total number of patients with at least one serious AE                                                85 (63.4%)    80 (59.7%)     87 (65.9%)  
+  No. of patients with study drug 1 withdrawn due to serious AE                                       9 (6.7%)      4 (3.0%)      10 (7.6%)   
+  No. of patients with study drug 2 withdrawn due to serious AE                                       9 (6.7%)      4 (3.0%)      10 (7.6%)   
+  No. of patients with dose of study drug 1 modified/interrupted due to serious AE                   21 (15.7%)    22 (16.4%)     28 (21.2%)  
+  No. of patients with dose of study drug 2 modified/interrupted due to serious AE                   21 (15.7%)    22 (16.4%)     28 (21.2%)  
+  No. of patients with treatment received for serious AE                                             59 (44.0%)    58 (43.3%)     53 (40.2%)  
+Total number of patients with at least one AE related to study drug 1                                86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  No. of patients with study drug 1 withdrawn due to AE related to study drug 1                       5 (3.7%)     10 (7.5%)       7 (5.3%)   
+  No. of patients with study drug 1 withdrawn due to AE related to study drug 2                       5 (3.7%)     10 (7.5%)       7 (5.3%)   
+  No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 1   24 (17.9%)    32 (23.9%)     34 (25.8%)  
+  No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 2   24 (17.9%)    32 (23.9%)     34 (25.8%)  
+  No. of patients with treatment received for AE related to study drug 1                             53 (39.6%)    58 (43.3%)     60 (45.5%)  
+  No. of patients with serious AE related to study drug 1                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  
+Total number of patients with at least one AE related to study drug 2                                86 (64.2%)    85 (63.4%)     92 (69.7%)  
+  No. of patients with study drug 2 withdrawn due to AE related to study drug 1                       5 (3.7%)     10 (7.5%)       7 (5.3%)   
+  No. of patients with study drug 2 withdrawn due to AE related to study drug 2                       5 (3.7%)     10 (7.5%)       7 (5.3%)   
+  No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 1   24 (17.9%)    32 (23.9%)     34 (25.8%)  
+  No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 2   24 (17.9%)    32 (23.9%)     34 (25.8%)  
+  No. of patients with treatment received for AE related to study drug 2                             53 (39.6%)    58 (43.3%)     60 (45.5%)  
+  No. of patients with serious AE related to study drug 2                                            64 (47.8%)    52 (38.8%)     64 (48.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet01_aesi_cache/html/variant4_55d557871bc27d069047c573160591e7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-5"><a href="#cb8-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-8"><a href="#cb8-8"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>stack_adae_by_smq <span class="ot">&lt;-</span> <span class="cf">function</span>(adae, smq) {</span>
+<span id="cb8-11"><a href="#cb8-11"></a>  adae_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">var_labels</span>(adae), <span class="st">"Standardized MedDRA Query"</span>)</span>
+<span id="cb8-12"><a href="#cb8-12"></a>  l_df <span class="ot">&lt;-</span> <span class="fu">lapply</span>(smq, <span class="cf">function</span>(ae_grp) {</span>
+<span id="cb8-13"><a href="#cb8-13"></a>    ae_scope <span class="ot">&lt;-</span> <span class="fu">gsub</span>(<span class="st">"NAM"</span>, <span class="st">"SC"</span>, ae_grp)</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    keep <span class="ot">&lt;-</span> adae[[ae_grp]] <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a>    df <span class="ot">&lt;-</span> adae[keep, ]</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="cf">if</span> (<span class="fu">substr</span>(ae_grp, <span class="dv">1</span>, <span class="dv">3</span>) <span class="sc">==</span> <span class="st">"SMQ"</span>) {</span>
+<span id="cb8-17"><a href="#cb8-17"></a>      df[[<span class="st">"SMQ"</span>]] <span class="ot">&lt;-</span> <span class="fu">aesi_label</span>(<span class="fu">as.character</span>(df[[ae_grp]]), <span class="at">scope =</span> <span class="fu">as.character</span>(df[[ae_scope]]))</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    } <span class="cf">else</span> {</span>
+<span id="cb8-19"><a href="#cb8-19"></a>      df[[<span class="st">"SMQ"</span>]] <span class="ot">&lt;-</span> df[[ae_grp]]</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    }</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    df</span>
+<span id="cb8-22"><a href="#cb8-22"></a>  })</span>
+<span id="cb8-23"><a href="#cb8-23"></a>  result <span class="ot">&lt;-</span> <span class="fu">do.call</span>(rbind, l_df)</span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">var_labels</span>(result) <span class="ot">&lt;-</span> adae_labels</span>
+<span id="cb8-25"><a href="#cb8-25"></a>  result</span>
+<span id="cb8-26"><a href="#cb8-26"></a>}</span>
+<span id="cb8-27"><a href="#cb8-27"></a></span>
+<span id="cb8-28"><a href="#cb8-28"></a>adae_smq <span class="ot">&lt;-</span> <span class="fu">stack_adae_by_smq</span>(adae, <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>))</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a>not_resolved <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-34"><a href="#cb8-34"></a></span>
+<span id="cb8-35"><a href="#cb8-35"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  )</span>
+<span id="cb8-41"><a href="#cb8-41"></a></span>
+<span id="cb8-42"><a href="#cb8-42"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug withdrawn due to AE"</span>),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb8-47"><a href="#cb8-47"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Total number of patients with dose modified/interrupted due to AE"</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>    ),</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one related AE"</span>),</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to resolved AE"</span>),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to resolved AE"</span>),</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to unresolved or ongoing AE"</span>),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to serious AE"</span>),</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for serious AE"</span>),</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb8-62"><a href="#cb8-62"></a>      <span class="st">"No. of patients with dose modified/interrupted due to serious AE"</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a>    ),</span>
+<span id="cb8-64"><a href="#cb8-64"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to related AE"</span>),</span>
+<span id="cb8-65"><a href="#cb8-65"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb8-66"><a href="#cb8-66"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb8-67"><a href="#cb8-67"></a>      <span class="st">"No. of patients with dose modified/interrupted due to related AE"</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>    ),</span>
+<span id="cb8-69"><a href="#cb8-69"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for related AE"</span>),</span>
+<span id="cb8-70"><a href="#cb8-70"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious, related AE"</span>)</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  )</span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-75"><a href="#cb8-75"></a>    <span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(AETOXGR,</span>
+<span id="cb8-76"><a href="#cb8-76"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb8-77"><a href="#cb8-77"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>      <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a>    )</span>
+<span id="cb8-82"><a href="#cb8-82"></a>  )</span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a>split_fun <span class="ot">&lt;-</span> <span class="fu">remove_split_levels</span>(<span class="st">"&lt;Missing&gt;"</span>)</span>
+<span id="cb8-85"><a href="#cb8-85"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED"</span>, <span class="st">"NOT_RESOLVED"</span>, <span class="st">"SER"</span>, <span class="st">"REL"</span>)</span>
+<span id="cb8-86"><a href="#cb8-86"></a></span>
+<span id="cb8-87"><a href="#cb8-87"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-88"><a href="#cb8-88"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-89"><a href="#cb8-89"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-90"><a href="#cb8-90"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb8-91"><a href="#cb8-91"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-92"><a href="#cb8-92"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-93"><a href="#cb8-93"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span>,</span>
+<span id="cb8-94"><a href="#cb8-94"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb8-95"><a href="#cb8-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb8-97"><a href="#cb8-97"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-98"><a href="#cb8-98"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb8-99"><a href="#cb8-99"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb8-100"><a href="#cb8-100"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb8-101"><a href="#cb8-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-102"><a href="#cb8-102"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-105"><a href="#cb8-105"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-106"><a href="#cb8-106"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb8-107"><a href="#cb8-107"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb8-108"><a href="#cb8-108"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-109"><a href="#cb8-109"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb8-110"><a href="#cb8-110"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb8-111"><a href="#cb8-111"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb8-112"><a href="#cb8-112"></a>    <span class="at">.show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-114"><a href="#cb8-114"></a>  <span class="fu">count_patients_with_flags</span>(<span class="st">"USUBJID"</span>, <span class="at">flag_variables =</span> aesi_vars, <span class="at">denom =</span> <span class="st">"N_col"</span>)</span>
+<span id="cb8-115"><a href="#cb8-115"></a></span>
+<span id="cb8-116"><a href="#cb8-116"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae_smq, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-117"><a href="#cb8-117"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                                         A: Drug X    B: Placebo   C: Combination
+                                                                                   (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+C.1.1.1.3/B.2.2.3.1 AESI (BROAD)                                                                                          
+  Total number of patients with at least one AE                                   58 (43.3%)   60 (44.8%)     66 (50.0%)  
+  Total number of AEs                                                                 97          106            122      
+  Total number of patients with at least one AE by worst grade                                                            
+    Grade 1                                                                       22 (16.4%)   26 (19.4%)     30 (22.7%)  
+    Grade 2                                                                           0            0              0       
+    Grade 3                                                                           0            0              0       
+    Grade 4                                                                       36 (26.9%)   34 (25.4%)     36 (27.3%)  
+    Grade 5 (fatal outcome)                                                           0            0              0       
+  Total number of patients with study drug withdrawn due to AE                     5 (3.7%)     6 (4.5%)       9 (6.8%)   
+  Total number of patients with dose modified/interrupted due to AE               21 (15.7%)   21 (15.7%)     24 (18.2%)  
+  Total number of patients with treatment received for AE                         32 (23.9%)   35 (26.1%)     44 (33.3%)  
+  Total number of patients with all non-fatal AEs resolved                         7 (5.2%)     9 (6.7%)       8 (6.1%)   
+  Total number of patients with at least one non-fatal unresolved or ongoing AE   51 (38.1%)   51 (38.1%)     58 (43.9%)  
+  Total number of patients with at least one serious AE                           38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  Total number of patients with at least one related AE                           36 (26.9%)   34 (25.4%)     36 (27.3%)  
+D.2.1.5.3/A.1.1.1.1 AESI                                                                                                  
+  Total number of patients with at least one AE                                   62 (46.3%)   61 (45.5%)     76 (57.6%)  
+  Total number of AEs                                                                106          100            139      
+  Total number of patients with at least one AE by worst grade                                                            
+    Grade 1                                                                       62 (46.3%)   61 (45.5%)     76 (57.6%)  
+    Grade 2                                                                           0            0              0       
+    Grade 3                                                                           0            0              0       
+    Grade 4                                                                           0            0              0       
+    Grade 5 (fatal outcome)                                                           0            0              0       
+  Total number of patients with study drug withdrawn due to AE                     6 (4.5%)     8 (6.0%)       4 (3.0%)   
+  Total number of patients with dose modified/interrupted due to AE               23 (17.2%)   20 (14.9%)     26 (19.7%)  
+  Total number of patients with treatment received for AE                         33 (24.6%)   37 (27.6%)     33 (25.0%)  
+  Total number of patients with all non-fatal AEs resolved                         4 (3.0%)     5 (3.7%)      14 (10.6%)  
+  Total number of patients with at least one non-fatal unresolved or ongoing AE   58 (43.3%)   56 (41.8%)     62 (47.0%)  
+  Total number of patients with at least one serious AE                               0            0              0       
+  Total number of patients with at least one related AE                           37 (27.6%)   46 (34.3%)     50 (37.9%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet01_aesi_cache/html/teal_d3d128dd8e7aee209c6cf9f99abb3e61">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-8"><a href="#cb10-8"></a></span>
+<span id="cb10-9"><a href="#cb10-9"></a>not_resolved <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-13"><a href="#cb10-13"></a></span>
+<span id="cb10-14"><a href="#cb10-14"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"All non-fatal AEs resolved"</span>),</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"At least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb10-19"><a href="#cb10-19"></a>  )</span>
+<span id="cb10-20"><a href="#cb10-20"></a></span>
+<span id="cb10-21"><a href="#cb10-21"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-23"><a href="#cb10-23"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb10-24"><a href="#cb10-24"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"AE that led to study drug withdrawal"</span>),</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb10-26"><a href="#cb10-26"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"AE that required treatment"</span>),</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE"</span>),</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE"</span>),</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that led to study drug withdrawal"</span>),</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that required treatment"</span>),</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that led to study drug withdrawal"</span>),</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that required treatment"</span>),</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Serious AE that led to study drug withdrawal"</span>),</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE that required treatment"</span>),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Serious AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>    ),</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Related AE that led to study drug withdrawal"</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>    ),</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb10-44"><a href="#cb10-44"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Related AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>    ),</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE that required treatment"</span>),</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious related AE"</span>)</span>
+<span id="cb10-48"><a href="#cb10-48"></a>  )</span>
+<span id="cb10-49"><a href="#cb10-49"></a></span>
+<span id="cb10-50"><a href="#cb10-50"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED_WD"</span>, <span class="st">"ALL_RESOLVED_DSM"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="st">"NOT_RESOLVED_WD"</span>, <span class="st">"NOT_RESOLVED_DSM"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  <span class="st">"SERCONTRT"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"RELCONTRT"</span>, <span class="st">"RELSER"</span></span>
+<span id="cb10-54"><a href="#cb10-54"></a>)</span>
+<span id="cb10-55"><a href="#cb10-55"></a></span>
+<span id="cb10-56"><a href="#cb10-56"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a><span class="st">      ADAE &lt;- filter(ADAE, ANL01FL == "Y" &amp; SAFFL == "Y")</span></span>
+<span id="cb10-61"><a href="#cb10-61"></a><span class="st">      not_resolved &lt;- ADAE %&gt;%</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a><span class="st">      filter(!(AEOUT %in% c("RECOVERED/RESOLVED", "FATAL", "RECOVERED/RESOLVED WITH SEQUELAE"))) %&gt;%</span></span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="st">      distinct(USUBJID) %&gt;% mutate(NOT_RESOLVED = "Y")</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="st">    ADAE &lt;- ADAE %&gt;%</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="st">      left_join(not_resolved, by = c("USUBJID")) %&gt;%</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="st">      mutate(</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="st">        ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), "All non-fatal AEs resolved"),</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a><span class="st">        NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), "At least one non-fatal unresolved or ongoing AE")</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="st">      )</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a><span class="st">    ADAE &lt;- ADAE %&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a><span class="st">      mutate(</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="st">        AEDECOD = as.character(AEDECOD),</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="st">        WD = with_label(AEACN == "DRUG WITHDRAWN", "AE that led to study drug withdrawal"),</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a><span class="st">        DSM = with_label(AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="st">        CONTRT = with_label(AECONTRT == "Y", "AE that required treatment"),</span></span>
+<span id="cb10-78"><a href="#cb10-78"></a><span class="st">        SER = with_label(AESER == "Y", "Serious AE"),</span></span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="st">        REL = with_label(AEREL == "Y", "Related AE"),</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a><span class="st">        ALL_RESOLVED_WD = with_label(WD == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that led to study drug withdrawal"),</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a><span class="st">        ALL_RESOLVED_DSM = with_label(DSM == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb10-82"><a href="#cb10-82"></a><span class="st">        ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that required treatment"),</span></span>
+<span id="cb10-83"><a href="#cb10-83"></a><span class="st">        NOT_RESOLVED_WD = with_label(WD == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that led to study drug withdrawal"),</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a><span class="st">        NOT_RESOLVED_DSM = with_label(DSM == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb10-85"><a href="#cb10-85"></a><span class="st">        NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that required treatment"),</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a><span class="st">        SERWD = with_label(AESER == "Y" &amp; AEACN == "DRUG WITHDRAWN", "Serious AE that led to study drug withdrawal"),</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a><span class="st">        SERCONTRT = with_label(AECONTRT == "Y" &amp; AESER == "Y", "Serious AE that required treatment"),</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a><span class="st">        SERDSM = with_label(</span></span>
+<span id="cb10-89"><a href="#cb10-89"></a><span class="st">          AESER == "Y" &amp; AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "Serious AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="st">        ),</span></span>
+<span id="cb10-91"><a href="#cb10-91"></a><span class="st">        RELWD = with_label(</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a><span class="st">          AEREL == "Y" &amp; AEACN == "DRUG WITHDRAWN", "Related AE that led to study drug withdrawal"</span></span>
+<span id="cb10-93"><a href="#cb10-93"></a><span class="st">        ),</span></span>
+<span id="cb10-94"><a href="#cb10-94"></a><span class="st">        RELDSM = with_label(</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a><span class="st">          AEREL == "Y" &amp; AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "Related AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a><span class="st">        ),</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="st">        RELCONTRT = with_label(AECONTRT == "Y" &amp; AEREL == "Y", "Related AE that required treatment"),</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="st">        RELSER = with_label(AESER == "Y" &amp; AEREL == "Y", "Serious related AE")</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="st">      )'</span>),</span>
+<span id="cb10-100"><a href="#cb10-100"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a>  ),</span>
+<span id="cb10-102"><a href="#cb10-102"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-103"><a href="#cb10-103"></a>    <span class="fu">tm_t_events_summary</span>(</span>
+<span id="cb10-104"><a href="#cb10-104"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Summary"</span>,</span>
+<span id="cb10-105"><a href="#cb10-105"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb10-106"><a href="#cb10-106"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-107"><a href="#cb10-107"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADSL"</span>, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-108"><a href="#cb10-108"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a>      ),</span>
+<span id="cb10-110"><a href="#cb10-110"></a>      <span class="at">flag_var_anl =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-111"><a href="#cb10-111"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, aesi_vars),</span>
+<span id="cb10-112"><a href="#cb10-112"></a>        <span class="at">selected =</span> aesi_vars[<span class="dv">1</span>],</span>
+<span id="cb10-113"><a href="#cb10-113"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-114"><a href="#cb10-114"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>      ),</span>
+<span id="cb10-116"><a href="#cb10-116"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-117"><a href="#cb10-117"></a>    )</span>
+<span id="cb10-118"><a href="#cb10-118"></a>  )</span>
+<span id="cb10-119"><a href="#cb10-119"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:23:38.8184 pid:11488 token:[] teal.modules.clinical Initializing tm_t_events_summary</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet01_aesi_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet01_aesi_cache/html/sessioninfo_6cddc567285068b5b8311cd79942b313">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet01_aesi_cache/html/snapshot_0958e19c583a7e9f0e7b5b30b5aa9043">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet01_aesi.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
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+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
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+  const manageTransitions = (selector, allowTransitions) => {
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+      } else {
+        el.classList.add('notransition');
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+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
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+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
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+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
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+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
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+        <span class="nav-page-text">AET02</span> <i class="bi bi-arrow-right-short"></i>
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> AET01_AESI</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Safety Summary (Adverse Events of Special Interest)</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a>To illustrate, additional variables such as flags (TRUE/FALSE) for selected AEs of interest.</span>
+<span id="cb16-14"><a href="#cb16-14"></a>Please consult your SAP on how to handle missing AE grades.</span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-18"><a href="#cb16-18"></a></span>
+<span id="cb16-19"><a href="#cb16-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-20"><a href="#cb16-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-21"><a href="#cb16-21"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-24"><a href="#cb16-24"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-25"><a href="#cb16-25"></a></span>
+<span id="cb16-26"><a href="#cb16-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-27"><a href="#cb16-27"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-28"><a href="#cb16-28"></a></span>
+<span id="cb16-29"><a href="#cb16-29"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-30"><a href="#cb16-30"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb16-31"><a href="#cb16-31"></a></span>
+<span id="cb16-32"><a href="#cb16-32"></a>not_resolved <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-33"><a href="#cb16-33"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb16-34"><a href="#cb16-34"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb16-35"><a href="#cb16-35"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-36"><a href="#cb16-36"></a></span>
+<span id="cb16-37"><a href="#cb16-37"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-38"><a href="#cb16-38"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-39"><a href="#cb16-39"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-40"><a href="#cb16-40"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb16-41"><a href="#cb16-41"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one unresolved or ongoing non-fatal AE"</span>)</span>
+<span id="cb16-42"><a href="#cb16-42"></a>  )</span>
+<span id="cb16-43"><a href="#cb16-43"></a></span>
+<span id="cb16-44"><a href="#cb16-44"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-46"><a href="#cb16-46"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb16-47"><a href="#cb16-47"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug withdrawn due to AE"</span>),</span>
+<span id="cb16-48"><a href="#cb16-48"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-49"><a href="#cb16-49"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Total number of patients with dose modified/interrupted due to AE"</span></span>
+<span id="cb16-50"><a href="#cb16-50"></a>    ),</span>
+<span id="cb16-51"><a href="#cb16-51"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb16-52"><a href="#cb16-52"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb16-53"><a href="#cb16-53"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one related AE"</span>),</span>
+<span id="cb16-54"><a href="#cb16-54"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to resolved AE"</span>),</span>
+<span id="cb16-55"><a href="#cb16-55"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to resolved AE"</span>),</span>
+<span id="cb16-56"><a href="#cb16-56"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb16-57"><a href="#cb16-57"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-59"><a href="#cb16-59"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb16-60"><a href="#cb16-60"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to serious AE"</span>),</span>
+<span id="cb16-61"><a href="#cb16-61"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with dose modified/interrupted due to serious AE"</span>),</span>
+<span id="cb16-62"><a href="#cb16-62"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-63"><a href="#cb16-63"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"No. of patients with treatment received for serious AE"</span></span>
+<span id="cb16-64"><a href="#cb16-64"></a>    ),</span>
+<span id="cb16-65"><a href="#cb16-65"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to related AE"</span>),</span>
+<span id="cb16-66"><a href="#cb16-66"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-67"><a href="#cb16-67"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-68"><a href="#cb16-68"></a>      <span class="st">"No. of patients with dose modified/interrupted due to related AE"</span></span>
+<span id="cb16-69"><a href="#cb16-69"></a>    ),</span>
+<span id="cb16-70"><a href="#cb16-70"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for related AE"</span>),</span>
+<span id="cb16-71"><a href="#cb16-71"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious, related AE"</span>)</span>
+<span id="cb16-72"><a href="#cb16-72"></a>  )</span>
+<span id="cb16-73"><a href="#cb16-73"></a></span>
+<span id="cb16-74"><a href="#cb16-74"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-76"><a href="#cb16-76"></a>    <span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(AETOXGR,</span>
+<span id="cb16-77"><a href="#cb16-77"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb16-78"><a href="#cb16-78"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb16-79"><a href="#cb16-79"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb16-80"><a href="#cb16-80"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb16-81"><a href="#cb16-81"></a>      <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb16-82"><a href="#cb16-82"></a>    )</span>
+<span id="cb16-83"><a href="#cb16-83"></a>  )</span>
+<span id="cb16-84"><a href="#cb16-84"></a><span class="in">```</span></span>
+<span id="cb16-85"><a href="#cb16-85"></a></span>
+<span id="cb16-86"><a href="#cb16-86"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-87"><a href="#cb16-87"></a></span>
+<span id="cb16-88"><a href="#cb16-88"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-89"><a href="#cb16-89"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED"</span>, <span class="st">"NOT_RESOLVED"</span>, <span class="st">"SER"</span>, <span class="st">"REL"</span>)</span>
+<span id="cb16-90"><a href="#cb16-90"></a></span>
+<span id="cb16-91"><a href="#cb16-91"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-93"><a href="#cb16-93"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-94"><a href="#cb16-94"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-95"><a href="#cb16-95"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-96"><a href="#cb16-96"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-97"><a href="#cb16-97"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb16-98"><a href="#cb16-98"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-99"><a href="#cb16-99"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-100"><a href="#cb16-100"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb16-101"><a href="#cb16-101"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-102"><a href="#cb16-102"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-103"><a href="#cb16-103"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb16-104"><a href="#cb16-104"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb16-105"><a href="#cb16-105"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-106"><a href="#cb16-106"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb16-107"><a href="#cb16-107"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb16-108"><a href="#cb16-108"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb16-109"><a href="#cb16-109"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-110"><a href="#cb16-110"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-111"><a href="#cb16-111"></a>  <span class="fu">count_patients_with_flags</span>(<span class="st">"USUBJID"</span>, <span class="at">flag_variables =</span> aesi_vars, <span class="at">denom =</span> <span class="st">"N_col"</span>)</span>
+<span id="cb16-112"><a href="#cb16-112"></a></span>
+<span id="cb16-113"><a href="#cb16-113"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-114"><a href="#cb16-114"></a>result</span>
+<span id="cb16-115"><a href="#cb16-115"></a><span class="in">```</span></span>
+<span id="cb16-116"><a href="#cb16-116"></a></span>
+<span id="cb16-117"><a href="#cb16-117"></a><span class="fu">## Table with &lt;br/&gt; Optional Lines</span></span>
+<span id="cb16-118"><a href="#cb16-118"></a></span>
+<span id="cb16-119"><a href="#cb16-119"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-120"><a href="#cb16-120"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>)</span>
+<span id="cb16-121"><a href="#cb16-121"></a>aesi_resolved <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ALL_RESOLVED"</span>, <span class="st">"ALL_RESOLVED_WD"</span>, <span class="st">"ALL_RESOLVED_DSM"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>)</span>
+<span id="cb16-122"><a href="#cb16-122"></a>aesi_not_resolved <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"NOT_RESOLVED"</span>, <span class="st">"NOT_RESOLVED_WD"</span>, <span class="st">"NOT_RESOLVED_DSM"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>)</span>
+<span id="cb16-123"><a href="#cb16-123"></a>aesi_ser <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>, <span class="st">"SERCONTRT"</span>)</span>
+<span id="cb16-124"><a href="#cb16-124"></a>aesi_rel <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"RELCONTRT"</span>, <span class="st">"RELSER"</span>)</span>
+<span id="cb16-125"><a href="#cb16-125"></a></span>
+<span id="cb16-126"><a href="#cb16-126"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-127"><a href="#cb16-127"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-128"><a href="#cb16-128"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-129"><a href="#cb16-129"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-130"><a href="#cb16-130"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-131"><a href="#cb16-131"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-132"><a href="#cb16-132"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb16-133"><a href="#cb16-133"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-134"><a href="#cb16-134"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-135"><a href="#cb16-135"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb16-136"><a href="#cb16-136"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-137"><a href="#cb16-137"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-138"><a href="#cb16-138"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb16-139"><a href="#cb16-139"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb16-140"><a href="#cb16-140"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-141"><a href="#cb16-141"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb16-142"><a href="#cb16-142"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb16-143"><a href="#cb16-143"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb16-144"><a href="#cb16-144"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-145"><a href="#cb16-145"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-146"><a href="#cb16-146"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-147"><a href="#cb16-147"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-148"><a href="#cb16-148"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(aesi_vars, aesi_resolved[<span class="dv">1</span>]), <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb16-149"><a href="#cb16-149"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-150"><a href="#cb16-150"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-151"><a href="#cb16-151"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-152"><a href="#cb16-152"></a>    <span class="at">flag_variables =</span> aesi_resolved[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_res"</span></span>
+<span id="cb16-153"><a href="#cb16-153"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-154"><a href="#cb16-154"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-155"><a href="#cb16-155"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-156"><a href="#cb16-156"></a>    <span class="at">flag_variables =</span> aesi_not_resolved[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_notres_main"</span></span>
+<span id="cb16-157"><a href="#cb16-157"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-159"><a href="#cb16-159"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-160"><a href="#cb16-160"></a>    <span class="at">flag_variables =</span> aesi_not_resolved[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_notres"</span></span>
+<span id="cb16-161"><a href="#cb16-161"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-162"><a href="#cb16-162"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-163"><a href="#cb16-163"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-164"><a href="#cb16-164"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_ser_main"</span></span>
+<span id="cb16-165"><a href="#cb16-165"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-167"><a href="#cb16-167"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-168"><a href="#cb16-168"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb16-169"><a href="#cb16-169"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-170"><a href="#cb16-170"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-171"><a href="#cb16-171"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-172"><a href="#cb16-172"></a>    <span class="at">flag_variables =</span> aesi_rel[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel_main"</span></span>
+<span id="cb16-173"><a href="#cb16-173"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-175"><a href="#cb16-175"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-176"><a href="#cb16-176"></a>    <span class="at">flag_variables =</span> aesi_rel[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel"</span></span>
+<span id="cb16-177"><a href="#cb16-177"></a>  )</span>
+<span id="cb16-178"><a href="#cb16-178"></a></span>
+<span id="cb16-179"><a href="#cb16-179"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-180"><a href="#cb16-180"></a>result</span>
+<span id="cb16-181"><a href="#cb16-181"></a><span class="in">```</span></span>
+<span id="cb16-182"><a href="#cb16-182"></a></span>
+<span id="cb16-183"><a href="#cb16-183"></a><span class="fu">## Table For Studies &lt;br/&gt; with Multiple Drugs</span></span>
+<span id="cb16-184"><a href="#cb16-184"></a></span>
+<span id="cb16-185"><a href="#cb16-185"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-186"><a href="#cb16-186"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-187"><a href="#cb16-187"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-188"><a href="#cb16-188"></a></span>
+<span id="cb16-189"><a href="#cb16-189"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-190"><a href="#cb16-190"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae_mult, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-191"><a href="#cb16-191"></a></span>
+<span id="cb16-192"><a href="#cb16-192"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-193"><a href="#cb16-193"></a>adae_mult <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae_mult)</span>
+<span id="cb16-194"><a href="#cb16-194"></a></span>
+<span id="cb16-195"><a href="#cb16-195"></a><span class="co"># for illustration purposes only, create AEREL1, AEREL2, AEACN1, AEACN2 from respective variables</span></span>
+<span id="cb16-196"><a href="#cb16-196"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb16-197"><a href="#cb16-197"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-198"><a href="#cb16-198"></a>    <span class="at">AEREL1 =</span> AEREL,</span>
+<span id="cb16-199"><a href="#cb16-199"></a>    <span class="at">AEREL2 =</span> AEREL,</span>
+<span id="cb16-200"><a href="#cb16-200"></a>    <span class="at">AEACN1 =</span> AEACN,</span>
+<span id="cb16-201"><a href="#cb16-201"></a>    <span class="at">AEACN2 =</span> AEACN</span>
+<span id="cb16-202"><a href="#cb16-202"></a>  )</span>
+<span id="cb16-203"><a href="#cb16-203"></a></span>
+<span id="cb16-204"><a href="#cb16-204"></a>not_resolved <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb16-205"><a href="#cb16-205"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb16-206"><a href="#cb16-206"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb16-207"><a href="#cb16-207"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-208"><a href="#cb16-208"></a></span>
+<span id="cb16-209"><a href="#cb16-209"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb16-210"><a href="#cb16-210"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-211"><a href="#cb16-211"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-212"><a href="#cb16-212"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb16-213"><a href="#cb16-213"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb16-214"><a href="#cb16-214"></a>  )</span>
+<span id="cb16-215"><a href="#cb16-215"></a></span>
+<span id="cb16-216"><a href="#cb16-216"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb16-217"><a href="#cb16-217"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-218"><a href="#cb16-218"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb16-219"><a href="#cb16-219"></a>    <span class="at">WD1 =</span> <span class="fu">with_label</span>(AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug 1 withdrawn due to AE"</span>),</span>
+<span id="cb16-220"><a href="#cb16-220"></a>    <span class="at">WD2 =</span> <span class="fu">with_label</span>(AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug 2 withdrawn due to AE"</span>),</span>
+<span id="cb16-221"><a href="#cb16-221"></a>    <span class="at">DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-222"><a href="#cb16-222"></a>      AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-223"><a href="#cb16-223"></a>      <span class="st">"Total number of patients with dose of study drug 1 modified/interrupted due to AE"</span></span>
+<span id="cb16-224"><a href="#cb16-224"></a>    ),</span>
+<span id="cb16-225"><a href="#cb16-225"></a>    <span class="at">DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-226"><a href="#cb16-226"></a>      AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-227"><a href="#cb16-227"></a>      <span class="st">"Total number of patients with dose of study drug 2 modified/interrupted due to AE"</span></span>
+<span id="cb16-228"><a href="#cb16-228"></a>    ),</span>
+<span id="cb16-229"><a href="#cb16-229"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb16-230"><a href="#cb16-230"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb16-231"><a href="#cb16-231"></a>    <span class="at">REL1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one AE related to study drug 1"</span>),</span>
+<span id="cb16-232"><a href="#cb16-232"></a>    <span class="at">REL2 =</span> <span class="fu">with_label</span>(AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one AE related to study drug 2"</span>),</span>
+<span id="cb16-233"><a href="#cb16-233"></a>    <span class="at">ALL_RESOLVED_WD1 =</span> <span class="fu">with_label</span>(WD1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to resolved AE"</span>),</span>
+<span id="cb16-234"><a href="#cb16-234"></a>    <span class="at">ALL_RESOLVED_DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-235"><a href="#cb16-235"></a>      DSM1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to resolved AE"</span></span>
+<span id="cb16-236"><a href="#cb16-236"></a>    ),</span>
+<span id="cb16-237"><a href="#cb16-237"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb16-238"><a href="#cb16-238"></a>    <span class="at">ALL_RESOLVED_WD2 =</span> <span class="fu">with_label</span>(WD2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to resolved AE"</span>),</span>
+<span id="cb16-239"><a href="#cb16-239"></a>    <span class="at">ALL_RESOLVED_DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-240"><a href="#cb16-240"></a>      DSM2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to resolved AE"</span></span>
+<span id="cb16-241"><a href="#cb16-241"></a>    ),</span>
+<span id="cb16-242"><a href="#cb16-242"></a>    <span class="at">NOT_RESOLVED_WD1 =</span> <span class="fu">with_label</span>(WD1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-243"><a href="#cb16-243"></a>    <span class="at">NOT_RESOLVED_DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-244"><a href="#cb16-244"></a>      DSM1 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to unresolved or ongoing AE"</span></span>
+<span id="cb16-245"><a href="#cb16-245"></a>    ),</span>
+<span id="cb16-246"><a href="#cb16-246"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb16-247"><a href="#cb16-247"></a>    <span class="at">NOT_RESOLVED_WD2 =</span> <span class="fu">with_label</span>(WD2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-248"><a href="#cb16-248"></a>    <span class="at">NOT_RESOLVED_DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-249"><a href="#cb16-249"></a>      DSM2 <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to unresolved or ongoing AE"</span></span>
+<span id="cb16-250"><a href="#cb16-250"></a>    ),</span>
+<span id="cb16-251"><a href="#cb16-251"></a>    <span class="at">SERWD1 =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to serious AE"</span>),</span>
+<span id="cb16-252"><a href="#cb16-252"></a>    <span class="at">SERWD2 =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to serious AE"</span>),</span>
+<span id="cb16-253"><a href="#cb16-253"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for serious AE"</span>),</span>
+<span id="cb16-254"><a href="#cb16-254"></a>    <span class="at">SERDSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-255"><a href="#cb16-255"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-256"><a href="#cb16-256"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to serious AE"</span></span>
+<span id="cb16-257"><a href="#cb16-257"></a>    ),</span>
+<span id="cb16-258"><a href="#cb16-258"></a>    <span class="at">SERDSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-259"><a href="#cb16-259"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-260"><a href="#cb16-260"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to serious AE"</span></span>
+<span id="cb16-261"><a href="#cb16-261"></a>    ),</span>
+<span id="cb16-262"><a href="#cb16-262"></a>    <span class="at">REL1WD1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to AE related to study drug 1"</span>),</span>
+<span id="cb16-263"><a href="#cb16-263"></a>    <span class="at">REL1WD2 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 1 withdrawn due to AE related to study drug 2"</span>),</span>
+<span id="cb16-264"><a href="#cb16-264"></a>    <span class="at">REL2WD1 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to AE related to study drug 1"</span>),</span>
+<span id="cb16-265"><a href="#cb16-265"></a>    <span class="at">REL2WD2 =</span> <span class="fu">with_label</span>(AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug 2 withdrawn due to AE related to study drug 2"</span>),</span>
+<span id="cb16-266"><a href="#cb16-266"></a>    <span class="at">REL1DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-267"><a href="#cb16-267"></a>      AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-268"><a href="#cb16-268"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 1"</span></span>
+<span id="cb16-269"><a href="#cb16-269"></a>    ),</span>
+<span id="cb16-270"><a href="#cb16-270"></a>    <span class="at">REL2DSM1 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-271"><a href="#cb16-271"></a>      AEREL2 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN1 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-272"><a href="#cb16-272"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 1"</span></span>
+<span id="cb16-273"><a href="#cb16-273"></a>    ),</span>
+<span id="cb16-274"><a href="#cb16-274"></a>    <span class="at">REL1DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-275"><a href="#cb16-275"></a>      AEREL1 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-276"><a href="#cb16-276"></a>      <span class="st">"No. of patients with dose of study drug 1 modified/interrupted due to AE related to study drug 2"</span></span>
+<span id="cb16-277"><a href="#cb16-277"></a>    ),</span>
+<span id="cb16-278"><a href="#cb16-278"></a>    <span class="at">REL2DSM2 =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-279"><a href="#cb16-279"></a>      AEREL2 <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN2 <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-280"><a href="#cb16-280"></a>      <span class="st">"No. of patients with dose of study drug 2 modified/interrupted due to AE related to study drug 2"</span></span>
+<span id="cb16-281"><a href="#cb16-281"></a>    ),</span>
+<span id="cb16-282"><a href="#cb16-282"></a>    <span class="at">REL1CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for AE related to study drug 1"</span>),</span>
+<span id="cb16-283"><a href="#cb16-283"></a>    <span class="at">REL2CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for AE related to study drug 2"</span>),</span>
+<span id="cb16-284"><a href="#cb16-284"></a>    <span class="at">REL1SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL1 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious AE related to study drug 1"</span>),</span>
+<span id="cb16-285"><a href="#cb16-285"></a>    <span class="at">REL2SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL2 <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious AE related to study drug 2"</span>)</span>
+<span id="cb16-286"><a href="#cb16-286"></a>  )</span>
+<span id="cb16-287"><a href="#cb16-287"></a></span>
+<span id="cb16-288"><a href="#cb16-288"></a>adae_mult <span class="ot">&lt;-</span> adae_mult <span class="sc">%&gt;%</span></span>
+<span id="cb16-289"><a href="#cb16-289"></a>  <span class="fu">mutate</span>(<span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb16-290"><a href="#cb16-290"></a>    AETOXGR,</span>
+<span id="cb16-291"><a href="#cb16-291"></a>    <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb16-292"><a href="#cb16-292"></a>    <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb16-293"><a href="#cb16-293"></a>    <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb16-294"><a href="#cb16-294"></a>    <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb16-295"><a href="#cb16-295"></a>    <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb16-296"><a href="#cb16-296"></a>  ))</span>
+<span id="cb16-297"><a href="#cb16-297"></a></span>
+<span id="cb16-298"><a href="#cb16-298"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD1"</span>, <span class="st">"WD2"</span>, <span class="st">"DSM1"</span>, <span class="st">"DSM2"</span>, <span class="st">"CONTRT"</span>)</span>
+<span id="cb16-299"><a href="#cb16-299"></a>aesi_res <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ALL_RESOLVED"</span>, <span class="st">"ALL_RESOLVED_WD1"</span>, <span class="st">"ALL_RESOLVED_WD2"</span>, <span class="st">"ALL_RESOLVED_DSM1"</span>, <span class="st">"ALL_RESOLVED_DSM2"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>)</span>
+<span id="cb16-300"><a href="#cb16-300"></a>aesi_not_res <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"NOT_RESOLVED"</span>, <span class="st">"NOT_RESOLVED_WD1"</span>, <span class="st">"NOT_RESOLVED_WD2"</span>, <span class="st">"NOT_RESOLVED_DSM1"</span>, <span class="st">"NOT_RESOLVED_DSM2"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>)</span>
+<span id="cb16-301"><a href="#cb16-301"></a>aesi_ser <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"SER"</span>, <span class="st">"SERWD1"</span>, <span class="st">"SERWD2"</span>, <span class="st">"SERDSM1"</span>, <span class="st">"SERDSM2"</span>, <span class="st">"SERCONTRT"</span>)</span>
+<span id="cb16-302"><a href="#cb16-302"></a>aesi_rel1 <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL1"</span>, <span class="st">"REL1WD1"</span>, <span class="st">"REL1WD2"</span>, <span class="st">"REL1DSM1"</span>, <span class="st">"REL1DSM2"</span>, <span class="st">"REL1CONTRT"</span>, <span class="st">"REL1SER"</span>)</span>
+<span id="cb16-303"><a href="#cb16-303"></a>aesi_rel2 <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"REL2"</span>, <span class="st">"REL2WD1"</span>, <span class="st">"REL2WD2"</span>, <span class="st">"REL2DSM1"</span>, <span class="st">"REL2DSM2"</span>, <span class="st">"REL2CONTRT"</span>, <span class="st">"REL2SER"</span>)</span>
+<span id="cb16-304"><a href="#cb16-304"></a></span>
+<span id="cb16-305"><a href="#cb16-305"></a>lyt_adae_mult <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-306"><a href="#cb16-306"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-307"><a href="#cb16-307"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-308"><a href="#cb16-308"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-309"><a href="#cb16-309"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-310"><a href="#cb16-310"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-311"><a href="#cb16-311"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb16-312"><a href="#cb16-312"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-313"><a href="#cb16-313"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-314"><a href="#cb16-314"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb16-315"><a href="#cb16-315"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-316"><a href="#cb16-316"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-317"><a href="#cb16-317"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb16-318"><a href="#cb16-318"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb16-319"><a href="#cb16-319"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-320"><a href="#cb16-320"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb16-321"><a href="#cb16-321"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb16-322"><a href="#cb16-322"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb16-323"><a href="#cb16-323"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-324"><a href="#cb16-324"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-325"><a href="#cb16-325"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-326"><a href="#cb16-326"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-327"><a href="#cb16-327"></a>    <span class="at">flag_variables =</span> <span class="fu">c</span>(aesi_vars, aesi_res[<span class="dv">1</span>]), <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb16-328"><a href="#cb16-328"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-329"><a href="#cb16-329"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-330"><a href="#cb16-330"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-331"><a href="#cb16-331"></a>    <span class="at">flag_variables =</span> aesi_res[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_res"</span></span>
+<span id="cb16-332"><a href="#cb16-332"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-333"><a href="#cb16-333"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-334"><a href="#cb16-334"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-335"><a href="#cb16-335"></a>    <span class="at">flag_variables =</span> aesi_not_res[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_notres_main"</span></span>
+<span id="cb16-336"><a href="#cb16-336"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-337"><a href="#cb16-337"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-338"><a href="#cb16-338"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-339"><a href="#cb16-339"></a>    <span class="at">flag_variables =</span> aesi_not_res[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_notres"</span></span>
+<span id="cb16-340"><a href="#cb16-340"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-341"><a href="#cb16-341"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-342"><a href="#cb16-342"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-343"><a href="#cb16-343"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_ser_main"</span></span>
+<span id="cb16-344"><a href="#cb16-344"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-345"><a href="#cb16-345"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-346"><a href="#cb16-346"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-347"><a href="#cb16-347"></a>    <span class="at">flag_variables =</span> aesi_ser[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb16-348"><a href="#cb16-348"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-349"><a href="#cb16-349"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-350"><a href="#cb16-350"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-351"><a href="#cb16-351"></a>    <span class="at">flag_variables =</span> aesi_rel1[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel1_main"</span></span>
+<span id="cb16-352"><a href="#cb16-352"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-353"><a href="#cb16-353"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-354"><a href="#cb16-354"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-355"><a href="#cb16-355"></a>    <span class="at">flag_variables =</span> aesi_rel1[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel1"</span></span>
+<span id="cb16-356"><a href="#cb16-356"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-357"><a href="#cb16-357"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-358"><a href="#cb16-358"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-359"><a href="#cb16-359"></a>    <span class="at">flag_variables =</span> aesi_rel2[<span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">table_names =</span> <span class="st">"fl_rel2_main"</span></span>
+<span id="cb16-360"><a href="#cb16-360"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-361"><a href="#cb16-361"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb16-362"><a href="#cb16-362"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-363"><a href="#cb16-363"></a>    <span class="at">flag_variables =</span> aesi_rel2[<span class="sc">-</span><span class="dv">1</span>], <span class="at">denom =</span> <span class="st">"N_col"</span>, <span class="at">.indent_mods =</span> 1L, <span class="at">table_names =</span> <span class="st">"fl_rel2"</span></span>
+<span id="cb16-364"><a href="#cb16-364"></a>  )</span>
+<span id="cb16-365"><a href="#cb16-365"></a></span>
+<span id="cb16-366"><a href="#cb16-366"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae_mult, <span class="at">df =</span> adae_mult, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-367"><a href="#cb16-367"></a>result</span>
+<span id="cb16-368"><a href="#cb16-368"></a><span class="in">```</span></span>
+<span id="cb16-369"><a href="#cb16-369"></a></span>
+<span id="cb16-370"><a href="#cb16-370"></a><span class="fu">## Table of AEs &lt;br/&gt; by SMQ</span></span>
+<span id="cb16-371"><a href="#cb16-371"></a></span>
+<span id="cb16-372"><a href="#cb16-372"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-373"><a href="#cb16-373"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-374"><a href="#cb16-374"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-375"><a href="#cb16-375"></a></span>
+<span id="cb16-376"><a href="#cb16-376"></a>adsl <span class="ot">&lt;-</span> <span class="fu">filter</span>(adsl, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-377"><a href="#cb16-377"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-378"><a href="#cb16-378"></a></span>
+<span id="cb16-379"><a href="#cb16-379"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-380"><a href="#cb16-380"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb16-381"><a href="#cb16-381"></a></span>
+<span id="cb16-382"><a href="#cb16-382"></a>stack_adae_by_smq <span class="ot">&lt;-</span> <span class="cf">function</span>(adae, smq) {</span>
+<span id="cb16-383"><a href="#cb16-383"></a>  adae_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">var_labels</span>(adae), <span class="st">"Standardized MedDRA Query"</span>)</span>
+<span id="cb16-384"><a href="#cb16-384"></a>  l_df <span class="ot">&lt;-</span> <span class="fu">lapply</span>(smq, <span class="cf">function</span>(ae_grp) {</span>
+<span id="cb16-385"><a href="#cb16-385"></a>    ae_scope <span class="ot">&lt;-</span> <span class="fu">gsub</span>(<span class="st">"NAM"</span>, <span class="st">"SC"</span>, ae_grp)</span>
+<span id="cb16-386"><a href="#cb16-386"></a>    keep <span class="ot">&lt;-</span> adae[[ae_grp]] <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb16-387"><a href="#cb16-387"></a>    df <span class="ot">&lt;-</span> adae[keep, ]</span>
+<span id="cb16-388"><a href="#cb16-388"></a>    <span class="cf">if</span> (<span class="fu">substr</span>(ae_grp, <span class="dv">1</span>, <span class="dv">3</span>) <span class="sc">==</span> <span class="st">"SMQ"</span>) {</span>
+<span id="cb16-389"><a href="#cb16-389"></a>      df[[<span class="st">"SMQ"</span>]] <span class="ot">&lt;-</span> <span class="fu">aesi_label</span>(<span class="fu">as.character</span>(df[[ae_grp]]), <span class="at">scope =</span> <span class="fu">as.character</span>(df[[ae_scope]]))</span>
+<span id="cb16-390"><a href="#cb16-390"></a>    } <span class="cf">else</span> {</span>
+<span id="cb16-391"><a href="#cb16-391"></a>      df[[<span class="st">"SMQ"</span>]] <span class="ot">&lt;-</span> df[[ae_grp]]</span>
+<span id="cb16-392"><a href="#cb16-392"></a>    }</span>
+<span id="cb16-393"><a href="#cb16-393"></a>    df</span>
+<span id="cb16-394"><a href="#cb16-394"></a>  })</span>
+<span id="cb16-395"><a href="#cb16-395"></a>  result <span class="ot">&lt;-</span> <span class="fu">do.call</span>(rbind, l_df)</span>
+<span id="cb16-396"><a href="#cb16-396"></a>  <span class="fu">var_labels</span>(result) <span class="ot">&lt;-</span> adae_labels</span>
+<span id="cb16-397"><a href="#cb16-397"></a>  result</span>
+<span id="cb16-398"><a href="#cb16-398"></a>}</span>
+<span id="cb16-399"><a href="#cb16-399"></a></span>
+<span id="cb16-400"><a href="#cb16-400"></a>adae_smq <span class="ot">&lt;-</span> <span class="fu">stack_adae_by_smq</span>(adae, <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>))</span>
+<span id="cb16-401"><a href="#cb16-401"></a></span>
+<span id="cb16-402"><a href="#cb16-402"></a>not_resolved <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb16-403"><a href="#cb16-403"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb16-404"><a href="#cb16-404"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb16-405"><a href="#cb16-405"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-406"><a href="#cb16-406"></a></span>
+<span id="cb16-407"><a href="#cb16-407"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb16-408"><a href="#cb16-408"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-409"><a href="#cb16-409"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-410"><a href="#cb16-410"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with all non-fatal AEs resolved"</span>),</span>
+<span id="cb16-411"><a href="#cb16-411"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"Total number of patients with at least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb16-412"><a href="#cb16-412"></a>  )</span>
+<span id="cb16-413"><a href="#cb16-413"></a></span>
+<span id="cb16-414"><a href="#cb16-414"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb16-415"><a href="#cb16-415"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-416"><a href="#cb16-416"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb16-417"><a href="#cb16-417"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Total number of patients with study drug withdrawn due to AE"</span>),</span>
+<span id="cb16-418"><a href="#cb16-418"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-419"><a href="#cb16-419"></a>      AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Total number of patients with dose modified/interrupted due to AE"</span></span>
+<span id="cb16-420"><a href="#cb16-420"></a>    ),</span>
+<span id="cb16-421"><a href="#cb16-421"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with treatment received for AE"</span>),</span>
+<span id="cb16-422"><a href="#cb16-422"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one serious AE"</span>),</span>
+<span id="cb16-423"><a href="#cb16-423"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Total number of patients with at least one related AE"</span>),</span>
+<span id="cb16-424"><a href="#cb16-424"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to resolved AE"</span>),</span>
+<span id="cb16-425"><a href="#cb16-425"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to resolved AE"</span>),</span>
+<span id="cb16-426"><a href="#cb16-426"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for resolved AE"</span>),</span>
+<span id="cb16-427"><a href="#cb16-427"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with study drug withdrawn due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-428"><a href="#cb16-428"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with dose modified/interrupted due to unresolved or ongoing AE"</span>),</span>
+<span id="cb16-429"><a href="#cb16-429"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"No. of patients with treatment received for unresolved or ongoing AE"</span>),</span>
+<span id="cb16-430"><a href="#cb16-430"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to serious AE"</span>),</span>
+<span id="cb16-431"><a href="#cb16-431"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for serious AE"</span>),</span>
+<span id="cb16-432"><a href="#cb16-432"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-433"><a href="#cb16-433"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-434"><a href="#cb16-434"></a>      <span class="st">"No. of patients with dose modified/interrupted due to serious AE"</span></span>
+<span id="cb16-435"><a href="#cb16-435"></a>    ),</span>
+<span id="cb16-436"><a href="#cb16-436"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"No. of patients with study drug withdrawn due to related AE"</span>),</span>
+<span id="cb16-437"><a href="#cb16-437"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-438"><a href="#cb16-438"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>),</span>
+<span id="cb16-439"><a href="#cb16-439"></a>      <span class="st">"No. of patients with dose modified/interrupted due to related AE"</span></span>
+<span id="cb16-440"><a href="#cb16-440"></a>    ),</span>
+<span id="cb16-441"><a href="#cb16-441"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with treatment received for related AE"</span>),</span>
+<span id="cb16-442"><a href="#cb16-442"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"No. of patients with serious, related AE"</span>)</span>
+<span id="cb16-443"><a href="#cb16-443"></a>  )</span>
+<span id="cb16-444"><a href="#cb16-444"></a></span>
+<span id="cb16-445"><a href="#cb16-445"></a>adae_smq <span class="ot">&lt;-</span> adae_smq <span class="sc">%&gt;%</span></span>
+<span id="cb16-446"><a href="#cb16-446"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-447"><a href="#cb16-447"></a>    <span class="at">AETOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(AETOXGR,</span>
+<span id="cb16-448"><a href="#cb16-448"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb16-449"><a href="#cb16-449"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb16-450"><a href="#cb16-450"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb16-451"><a href="#cb16-451"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb16-452"><a href="#cb16-452"></a>      <span class="st">"Grade 5 (fatal outcome)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb16-453"><a href="#cb16-453"></a>    )</span>
+<span id="cb16-454"><a href="#cb16-454"></a>  )</span>
+<span id="cb16-455"><a href="#cb16-455"></a></span>
+<span id="cb16-456"><a href="#cb16-456"></a>split_fun <span class="ot">&lt;-</span> <span class="fu">remove_split_levels</span>(<span class="st">"&lt;Missing&gt;"</span>)</span>
+<span id="cb16-457"><a href="#cb16-457"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED"</span>, <span class="st">"NOT_RESOLVED"</span>, <span class="st">"SER"</span>, <span class="st">"REL"</span>)</span>
+<span id="cb16-458"><a href="#cb16-458"></a></span>
+<span id="cb16-459"><a href="#cb16-459"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-460"><a href="#cb16-460"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-461"><a href="#cb16-461"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-462"><a href="#cb16-462"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb16-463"><a href="#cb16-463"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-464"><a href="#cb16-464"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-465"><a href="#cb16-465"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span>,</span>
+<span id="cb16-466"><a href="#cb16-466"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb16-467"><a href="#cb16-467"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-468"><a href="#cb16-468"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb16-469"><a href="#cb16-469"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-470"><a href="#cb16-470"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"ANL01FL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-471"><a href="#cb16-471"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-472"><a href="#cb16-472"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of patients with at least one AE"</span>)</span>
+<span id="cb16-473"><a href="#cb16-473"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-474"><a href="#cb16-474"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-475"><a href="#cb16-475"></a>    <span class="st">"ANL01FL"</span>,</span>
+<span id="cb16-476"><a href="#cb16-476"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb16-477"><a href="#cb16-477"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb16-478"><a href="#cb16-478"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb16-479"><a href="#cb16-479"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb16-480"><a href="#cb16-480"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-481"><a href="#cb16-481"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb16-482"><a href="#cb16-482"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb16-483"><a href="#cb16-483"></a>    <span class="at">var_labels =</span> <span class="st">"Total number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb16-484"><a href="#cb16-484"></a>    <span class="at">.show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb16-485"><a href="#cb16-485"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-486"><a href="#cb16-486"></a>  <span class="fu">count_patients_with_flags</span>(<span class="st">"USUBJID"</span>, <span class="at">flag_variables =</span> aesi_vars, <span class="at">denom =</span> <span class="st">"N_col"</span>)</span>
+<span id="cb16-487"><a href="#cb16-487"></a></span>
+<span id="cb16-488"><a href="#cb16-488"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae_smq, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb16-489"><a href="#cb16-489"></a>result</span>
+<span id="cb16-490"><a href="#cb16-490"></a><span class="in">```</span></span>
+<span id="cb16-491"><a href="#cb16-491"></a></span>
+<span id="cb16-492"><a href="#cb16-492"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-493"><a href="#cb16-493"></a></span>
+<span id="cb16-494"><a href="#cb16-494"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-495"><a href="#cb16-495"></a></span>
+<span id="cb16-496"><a href="#cb16-496"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-497"><a href="#cb16-497"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb16-498"><a href="#cb16-498"></a></span>
+<span id="cb16-499"><a href="#cb16-499"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-500"><a href="#cb16-500"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-501"><a href="#cb16-501"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-502"><a href="#cb16-502"></a></span>
+<span id="cb16-503"><a href="#cb16-503"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-504"><a href="#cb16-504"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb16-505"><a href="#cb16-505"></a>adae <span class="ot">&lt;-</span> <span class="fu">filter</span>(adae, ANL01FL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-506"><a href="#cb16-506"></a></span>
+<span id="cb16-507"><a href="#cb16-507"></a>not_resolved <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-508"><a href="#cb16-508"></a>  <span class="fu">filter</span>(<span class="sc">!</span>(AEOUT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"RECOVERED/RESOLVED"</span>, <span class="st">"FATAL"</span>, <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb16-509"><a href="#cb16-509"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb16-510"><a href="#cb16-510"></a>  <span class="fu">mutate</span>(<span class="at">NOT_RESOLVED =</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-511"><a href="#cb16-511"></a></span>
+<span id="cb16-512"><a href="#cb16-512"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-513"><a href="#cb16-513"></a>  <span class="fu">left_join</span>(not_resolved, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-514"><a href="#cb16-514"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-515"><a href="#cb16-515"></a>    <span class="at">ALL_RESOLVED =</span> <span class="fu">with_label</span>(<span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"All non-fatal AEs resolved"</span>),</span>
+<span id="cb16-516"><a href="#cb16-516"></a>    <span class="at">NOT_RESOLVED =</span> <span class="fu">with_label</span>(<span class="sc">!</span><span class="fu">is.na</span>(NOT_RESOLVED), <span class="st">"At least one non-fatal unresolved or ongoing AE"</span>)</span>
+<span id="cb16-517"><a href="#cb16-517"></a>  )</span>
+<span id="cb16-518"><a href="#cb16-518"></a></span>
+<span id="cb16-519"><a href="#cb16-519"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb16-520"><a href="#cb16-520"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-521"><a href="#cb16-521"></a>    <span class="at">AEDECOD =</span> <span class="fu">as.character</span>(AEDECOD),</span>
+<span id="cb16-522"><a href="#cb16-522"></a>    <span class="at">WD =</span> <span class="fu">with_label</span>(AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"AE that led to study drug withdrawal"</span>),</span>
+<span id="cb16-523"><a href="#cb16-523"></a>    <span class="at">DSM =</span> <span class="fu">with_label</span>(AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb16-524"><a href="#cb16-524"></a>    <span class="at">CONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"AE that required treatment"</span>),</span>
+<span id="cb16-525"><a href="#cb16-525"></a>    <span class="at">SER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE"</span>),</span>
+<span id="cb16-526"><a href="#cb16-526"></a>    <span class="at">REL =</span> <span class="fu">with_label</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE"</span>),</span>
+<span id="cb16-527"><a href="#cb16-527"></a>    <span class="at">ALL_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that led to study drug withdrawal"</span>),</span>
+<span id="cb16-528"><a href="#cb16-528"></a>    <span class="at">ALL_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb16-529"><a href="#cb16-529"></a>    <span class="at">ALL_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> ALL_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Resolved AE that required treatment"</span>),</span>
+<span id="cb16-530"><a href="#cb16-530"></a>    <span class="at">NOT_RESOLVED_WD =</span> <span class="fu">with_label</span>(WD <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that led to study drug withdrawal"</span>),</span>
+<span id="cb16-531"><a href="#cb16-531"></a>    <span class="at">NOT_RESOLVED_DSM =</span> <span class="fu">with_label</span>(DSM <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that led to study drug dose modified/interrupted"</span>),</span>
+<span id="cb16-532"><a href="#cb16-532"></a>    <span class="at">NOT_RESOLVED_CONTRT =</span> <span class="fu">with_label</span>(CONTRT <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">&amp;</span> NOT_RESOLVED <span class="sc">==</span> <span class="cn">TRUE</span>, <span class="st">"Unresolved AE that required treatment"</span>),</span>
+<span id="cb16-533"><a href="#cb16-533"></a>    <span class="at">SERWD =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Serious AE that led to study drug withdrawal"</span>),</span>
+<span id="cb16-534"><a href="#cb16-534"></a>    <span class="at">SERCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AESER <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious AE that required treatment"</span>),</span>
+<span id="cb16-535"><a href="#cb16-535"></a>    <span class="at">SERDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-536"><a href="#cb16-536"></a>      AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Serious AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb16-537"><a href="#cb16-537"></a>    ),</span>
+<span id="cb16-538"><a href="#cb16-538"></a>    <span class="at">RELWD =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-539"><a href="#cb16-539"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">==</span> <span class="st">"DRUG WITHDRAWN"</span>, <span class="st">"Related AE that led to study drug withdrawal"</span></span>
+<span id="cb16-540"><a href="#cb16-540"></a>    ),</span>
+<span id="cb16-541"><a href="#cb16-541"></a>    <span class="at">RELDSM =</span> <span class="fu">with_label</span>(</span>
+<span id="cb16-542"><a href="#cb16-542"></a>      AEREL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEACN <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"DRUG INTERRUPTED"</span>, <span class="st">"DOSE INCREASED"</span>, <span class="st">"DOSE REDUCED"</span>), <span class="st">"Related AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb16-543"><a href="#cb16-543"></a>    ),</span>
+<span id="cb16-544"><a href="#cb16-544"></a>    <span class="at">RELCONTRT =</span> <span class="fu">with_label</span>(AECONTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Related AE that required treatment"</span>),</span>
+<span id="cb16-545"><a href="#cb16-545"></a>    <span class="at">RELSER =</span> <span class="fu">with_label</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> AEREL <span class="sc">==</span> <span class="st">"Y"</span>, <span class="st">"Serious related AE"</span>)</span>
+<span id="cb16-546"><a href="#cb16-546"></a>  )</span>
+<span id="cb16-547"><a href="#cb16-547"></a></span>
+<span id="cb16-548"><a href="#cb16-548"></a>aesi_vars <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb16-549"><a href="#cb16-549"></a>  <span class="st">"WD"</span>, <span class="st">"DSM"</span>, <span class="st">"CONTRT"</span>, <span class="st">"ALL_RESOLVED_WD"</span>, <span class="st">"ALL_RESOLVED_DSM"</span>, <span class="st">"ALL_RESOLVED_CONTRT"</span>,</span>
+<span id="cb16-550"><a href="#cb16-550"></a>  <span class="st">"NOT_RESOLVED_WD"</span>, <span class="st">"NOT_RESOLVED_DSM"</span>, <span class="st">"NOT_RESOLVED_CONTRT"</span>, <span class="st">"SER"</span>, <span class="st">"SERWD"</span>, <span class="st">"SERDSM"</span>,</span>
+<span id="cb16-551"><a href="#cb16-551"></a>  <span class="st">"SERCONTRT"</span>, <span class="st">"REL"</span>, <span class="st">"RELWD"</span>, <span class="st">"RELDSM"</span>, <span class="st">"RELCONTRT"</span>, <span class="st">"RELSER"</span></span>
+<span id="cb16-552"><a href="#cb16-552"></a>)</span>
+<span id="cb16-553"><a href="#cb16-553"></a></span>
+<span id="cb16-554"><a href="#cb16-554"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-555"><a href="#cb16-555"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-556"><a href="#cb16-556"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb16-557"><a href="#cb16-557"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")</span></span>
+<span id="cb16-558"><a href="#cb16-558"></a><span class="st">      ADAE &lt;- filter(ADAE, ANL01FL == "Y" &amp; SAFFL == "Y")</span></span>
+<span id="cb16-559"><a href="#cb16-559"></a><span class="st">      not_resolved &lt;- ADAE %&gt;%</span></span>
+<span id="cb16-560"><a href="#cb16-560"></a><span class="st">      filter(!(AEOUT %in% c("RECOVERED/RESOLVED", "FATAL", "RECOVERED/RESOLVED WITH SEQUELAE"))) %&gt;%</span></span>
+<span id="cb16-561"><a href="#cb16-561"></a><span class="st">      distinct(USUBJID) %&gt;% mutate(NOT_RESOLVED = "Y")</span></span>
+<span id="cb16-562"><a href="#cb16-562"></a></span>
+<span id="cb16-563"><a href="#cb16-563"></a><span class="st">    ADAE &lt;- ADAE %&gt;%</span></span>
+<span id="cb16-564"><a href="#cb16-564"></a><span class="st">      left_join(not_resolved, by = c("USUBJID")) %&gt;%</span></span>
+<span id="cb16-565"><a href="#cb16-565"></a><span class="st">      mutate(</span></span>
+<span id="cb16-566"><a href="#cb16-566"></a><span class="st">        ALL_RESOLVED = with_label(is.na(NOT_RESOLVED), "All non-fatal AEs resolved"),</span></span>
+<span id="cb16-567"><a href="#cb16-567"></a><span class="st">        NOT_RESOLVED = with_label(!is.na(NOT_RESOLVED), "At least one non-fatal unresolved or ongoing AE")</span></span>
+<span id="cb16-568"><a href="#cb16-568"></a><span class="st">      )</span></span>
+<span id="cb16-569"><a href="#cb16-569"></a></span>
+<span id="cb16-570"><a href="#cb16-570"></a><span class="st">    ADAE &lt;- ADAE %&gt;%</span></span>
+<span id="cb16-571"><a href="#cb16-571"></a><span class="st">      mutate(</span></span>
+<span id="cb16-572"><a href="#cb16-572"></a><span class="st">        AEDECOD = as.character(AEDECOD),</span></span>
+<span id="cb16-573"><a href="#cb16-573"></a><span class="st">        WD = with_label(AEACN == "DRUG WITHDRAWN", "AE that led to study drug withdrawal"),</span></span>
+<span id="cb16-574"><a href="#cb16-574"></a><span class="st">        DSM = with_label(AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb16-575"><a href="#cb16-575"></a><span class="st">        CONTRT = with_label(AECONTRT == "Y", "AE that required treatment"),</span></span>
+<span id="cb16-576"><a href="#cb16-576"></a><span class="st">        SER = with_label(AESER == "Y", "Serious AE"),</span></span>
+<span id="cb16-577"><a href="#cb16-577"></a><span class="st">        REL = with_label(AEREL == "Y", "Related AE"),</span></span>
+<span id="cb16-578"><a href="#cb16-578"></a><span class="st">        ALL_RESOLVED_WD = with_label(WD == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that led to study drug withdrawal"),</span></span>
+<span id="cb16-579"><a href="#cb16-579"></a><span class="st">        ALL_RESOLVED_DSM = with_label(DSM == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb16-580"><a href="#cb16-580"></a><span class="st">        ALL_RESOLVED_CONTRT = with_label(CONTRT == TRUE &amp; ALL_RESOLVED == TRUE, "Resolved AE that required treatment"),</span></span>
+<span id="cb16-581"><a href="#cb16-581"></a><span class="st">        NOT_RESOLVED_WD = with_label(WD == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that led to study drug withdrawal"),</span></span>
+<span id="cb16-582"><a href="#cb16-582"></a><span class="st">        NOT_RESOLVED_DSM = with_label(DSM == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that led to study drug dose modified/interrupted"),</span></span>
+<span id="cb16-583"><a href="#cb16-583"></a><span class="st">        NOT_RESOLVED_CONTRT = with_label(CONTRT == TRUE &amp; NOT_RESOLVED == TRUE, "Unresolved AE that required treatment"),</span></span>
+<span id="cb16-584"><a href="#cb16-584"></a><span class="st">        SERWD = with_label(AESER == "Y" &amp; AEACN == "DRUG WITHDRAWN", "Serious AE that led to study drug withdrawal"),</span></span>
+<span id="cb16-585"><a href="#cb16-585"></a><span class="st">        SERCONTRT = with_label(AECONTRT == "Y" &amp; AESER == "Y", "Serious AE that required treatment"),</span></span>
+<span id="cb16-586"><a href="#cb16-586"></a><span class="st">        SERDSM = with_label(</span></span>
+<span id="cb16-587"><a href="#cb16-587"></a><span class="st">          AESER == "Y" &amp; AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "Serious AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb16-588"><a href="#cb16-588"></a><span class="st">        ),</span></span>
+<span id="cb16-589"><a href="#cb16-589"></a><span class="st">        RELWD = with_label(</span></span>
+<span id="cb16-590"><a href="#cb16-590"></a><span class="st">          AEREL == "Y" &amp; AEACN == "DRUG WITHDRAWN", "Related AE that led to study drug withdrawal"</span></span>
+<span id="cb16-591"><a href="#cb16-591"></a><span class="st">        ),</span></span>
+<span id="cb16-592"><a href="#cb16-592"></a><span class="st">        RELDSM = with_label(</span></span>
+<span id="cb16-593"><a href="#cb16-593"></a><span class="st">          AEREL == "Y" &amp; AEACN %in% c("DRUG INTERRUPTED", "DOSE INCREASED", "DOSE REDUCED"), "Related AE that led to study drug dose modified/interrupted"</span></span>
+<span id="cb16-594"><a href="#cb16-594"></a><span class="st">        ),</span></span>
+<span id="cb16-595"><a href="#cb16-595"></a><span class="st">        RELCONTRT = with_label(AECONTRT == "Y" &amp; AEREL == "Y", "Related AE that required treatment"),</span></span>
+<span id="cb16-596"><a href="#cb16-596"></a><span class="st">        RELSER = with_label(AESER == "Y" &amp; AEREL == "Y", "Serious related AE")</span></span>
+<span id="cb16-597"><a href="#cb16-597"></a><span class="st">      )'</span>),</span>
+<span id="cb16-598"><a href="#cb16-598"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-599"><a href="#cb16-599"></a>  ),</span>
+<span id="cb16-600"><a href="#cb16-600"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-601"><a href="#cb16-601"></a>    <span class="fu">tm_t_events_summary</span>(</span>
+<span id="cb16-602"><a href="#cb16-602"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Summary"</span>,</span>
+<span id="cb16-603"><a href="#cb16-603"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb16-604"><a href="#cb16-604"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-605"><a href="#cb16-605"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADSL"</span>, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb16-606"><a href="#cb16-606"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb16-607"><a href="#cb16-607"></a>      ),</span>
+<span id="cb16-608"><a href="#cb16-608"></a>      <span class="at">flag_var_anl =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-609"><a href="#cb16-609"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(<span class="st">"ADAE"</span>, aesi_vars),</span>
+<span id="cb16-610"><a href="#cb16-610"></a>        <span class="at">selected =</span> aesi_vars[<span class="dv">1</span>],</span>
+<span id="cb16-611"><a href="#cb16-611"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-612"><a href="#cb16-612"></a>        <span class="at">fixed =</span> <span class="cn">FALSE</span></span>
+<span id="cb16-613"><a href="#cb16-613"></a>      ),</span>
+<span id="cb16-614"><a href="#cb16-614"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-615"><a href="#cb16-615"></a>    )</span>
+<span id="cb16-616"><a href="#cb16-616"></a>  )</span>
+<span id="cb16-617"><a href="#cb16-617"></a>)</span>
+<span id="cb16-618"><a href="#cb16-618"></a></span>
+<span id="cb16-619"><a href="#cb16-619"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-620"><a href="#cb16-620"></a><span class="in">```</span></span>
+<span id="cb16-621"><a href="#cb16-621"></a></span>
+<span id="cb16-622"><a href="#cb16-622"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-623"><a href="#cb16-623"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+<link href="../../tables/adverse-events/aet01_aesi.html" rel="prev">
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+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
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+<meta property="og:title" content="TLG Catalog - AET02">
+<meta property="og:description" content="Adverse Events">
+<meta property="og:image" content="https://insightsengineering.github.io/tlg-catalog/tables/adverse-events/aet02_files/figure-html/teal-1.png">
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+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
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+ <span class="menu-text"></span></a>
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+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
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+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">
+<li>
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+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet01.html">Adverse Events</a></li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet02.html">AET02</a></li></ol></nav>
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+    </div>
+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
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+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
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+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with <br> Event Totals</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with <br> High-Level Term</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Preferred <br> Terms Only</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table with Fill-In of <br> Treatment Groups</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Table of AEs with an Incidence Rate <br><span class="math inline">\(\geq\)</span> 5% in Any Treatment Group (subsetting <br> preferred terms based on frequency)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Table of AEs with an Incidence Rate <span class="math inline">\(\geq\)</span> 5% in <br> Any Treatment Group (subsetting preferred terms <br> based on frequency with high-level terms)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Table of AEs with an Incidence Rate <span class="math inline">\(\geq\)</span> 10% <br> in Any Treatment Group (subsetting <br> preferred terms based on frequency)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false">Table of AEs with an Incidence Rate <span class="math inline">\(\geq\)</span> 3 <br> Patients in Any Treatment Group (subsetting <br> preferred terms based on number of patients)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false">Table of AEs with a Difference in Incidence Rate <span class="math inline">\(\geq\)</span> 5% <br> Between Any Treatment (subsetting preferred terms based <br> on difference in percentage between treatment groups)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-12-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-12" role="tab" aria-controls="tabset-1-12" aria-selected="false">Table of AEs with an Incidence Rate <span class="math inline">\(\geq\)</span> 5% <br> in B: Placebo (subsetting preferred terms based <br> on frequency for a particular treatment group)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-13-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-13" role="tab" aria-controls="tabset-1-13" aria-selected="false">Table of AEs with a Difference in Incidence Rate <span class="math inline">\(\geq\)</span> 5% Between <br> Arm A and Arm B or Arm C (displaying preferred terms with a <br> difference of at least x% between selected treatment groups)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-14-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-14" role="tab" aria-controls="tabset-1-14" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-15-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-15" role="tab" aria-controls="tabset-1-15" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet02_cache/html/setup_9ed22e2795f0470db23087653a66c172">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># Define the split function</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant1_27e8a16727d8ac253798c1a815a4da2f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>    )</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>    )</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb2-31"><a href="#cb2-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-33"><a href="#cb2-33"></a></span>
+<span id="cb2-34"><a href="#cb2-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p>The variable <code>result</code> corresponds to the adverse events table. However, it includes many empty rows accounting for events which were not reported. The table can be post-processed to prune empty rows and to sort rows, for example by occurrence.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant2_61269db25c556c4859c7e8e459b3f820">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb3-5"><a href="#cb3-5"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb3-6"><a href="#cb3-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb3-8"><a href="#cb3-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb3-9"><a href="#cb3-9"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb3-10"><a href="#cb3-10"></a>  )</span>
+<span id="cb3-11"><a href="#cb3-11"></a></span>
+<span id="cb3-12"><a href="#cb3-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination   All Patients
+  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)         (N=400)   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)    103 (78.0%)     301 (75.2%) 
+Overall total number of events                                   502          480            604             1586    
+cl A.1                                                                                                               
+  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)     202 (50.5%) 
+  Total number of events                                         115           99            137             351     
+  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)     128 (32.0%) 
+  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)     122 (30.5%) 
+cl B.2                                                                                                               
+  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)     74 (56.1%)     192 (48.0%) 
+  Total number of events                                         102          106            127             335     
+  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)     123 (30.8%) 
+  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)     119 (29.8%) 
+cl D.1                                                                                                               
+  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)     68 (51.5%)     186 (46.5%) 
+  Total number of events                                         106           84            114             304     
+  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)     120 (30.0%) 
+  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)     112 (28.0%) 
+cl D.2                                                                                                               
+  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) 
+  Total number of events                                         49            57             65             171     
+  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) 
+cl C.2                                                                                                               
+  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) 
+  Total number of events                                         39            40             57             136     
+  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) 
+cl B.1                                                                                                               
+  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) 
+  Total number of events                                         44            43             50             137     
+  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) 
+cl C.1                                                                                                               
+  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) 
+  Total number of events                                         47            51             54             152     
+  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant3_61b3fcba4b394137eb96bfaffd00e993">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb5-5"><a href="#cb5-5"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb5-6"><a href="#cb5-6"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb5-7"><a href="#cb5-7"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb5-8"><a href="#cb5-8"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb5-10"><a href="#cb5-10"></a>    )</span>
+<span id="cb5-11"><a href="#cb5-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb5-13"><a href="#cb5-13"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb5-14"><a href="#cb5-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb5-15"><a href="#cb5-15"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb5-16"><a href="#cb5-16"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb5-17"><a href="#cb5-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb5-18"><a href="#cb5-18"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb5-19"><a href="#cb5-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-20"><a href="#cb5-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb5-21"><a href="#cb5-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb5-22"><a href="#cb5-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb5-23"><a href="#cb5-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb5-24"><a href="#cb5-24"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb5-25"><a href="#cb5-25"></a>    )</span>
+<span id="cb5-26"><a href="#cb5-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-27"><a href="#cb5-27"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb5-28"><a href="#cb5-28"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb5-29"><a href="#cb5-29"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb5-30"><a href="#cb5-30"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb5-31"><a href="#cb5-31"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb5-32"><a href="#cb5-32"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb5-33"><a href="#cb5-33"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of events"</span>),</span>
+<span id="cb5-34"><a href="#cb5-34"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="sc">-</span>1L)</span>
+<span id="cb5-35"><a href="#cb5-35"></a>  )</span>
+<span id="cb5-36"><a href="#cb5-36"></a></span>
+<span id="cb5-37"><a href="#cb5-37"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span> <span class="co"># col_count = c(table(adsl$ACTARM), sum(table(adsl$ACTARM)))</span></span>
+<span id="cb5-38"><a href="#cb5-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-39"><a href="#cb5-39"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb5-40"><a href="#cb5-40"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb5-41"><a href="#cb5-41"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb5-42"><a href="#cb5-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-43"><a href="#cb5-43"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb5-44"><a href="#cb5-44"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb5-45"><a href="#cb5-45"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb5-46"><a href="#cb5-46"></a>  )</span>
+<span id="cb5-47"><a href="#cb5-47"></a></span>
+<span id="cb5-48"><a href="#cb5-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination   All Patients
+  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)         (N=400)   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)    103 (78.0%)     301 (75.2%) 
+Overall total number of events                                   502          480            604             1586    
+cl A.1                                                                                                               
+  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)     202 (50.5%) 
+  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)     128 (32.0%) 
+  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)     122 (30.5%) 
+  Total number of events                                         115           99            137             351     
+cl B.2                                                                                                               
+  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)     74 (56.1%)     192 (48.0%) 
+  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)     123 (30.8%) 
+  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)     119 (29.8%) 
+  Total number of events                                         102          106            127             335     
+cl D.1                                                                                                               
+  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)     68 (51.5%)     186 (46.5%) 
+  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)     120 (30.0%) 
+  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)     112 (28.0%) 
+  Total number of events                                         106           84            114             304     
+cl D.2                                                                                                               
+  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) 
+  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)     133 (33.2%) 
+  Total number of events                                         49            57             65             171     
+cl C.2                                                                                                               
+  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) 
+  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)     112 (28.0%) 
+  Total number of events                                         39            40             57             136     
+cl B.1                                                                                                               
+  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) 
+  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)     111 (27.8%) 
+  Total number of events                                         44            43             50             137     
+cl C.1                                                                                                               
+  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) 
+  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)     106 (26.5%) 
+  Total number of events                                         47            51             54             152     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant4_575e8783c40c5b08405645e65a433ac2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb7-4"><a href="#cb7-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb7-5"><a href="#cb7-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb7-6"><a href="#cb7-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb7-7"><a href="#cb7-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb7-8"><a href="#cb7-8"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb7-9"><a href="#cb7-9"></a>    )</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-11"><a href="#cb7-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-12"><a href="#cb7-12"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb7-15"><a href="#cb7-15"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-16"><a href="#cb7-16"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-17"><a href="#cb7-17"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb7-18"><a href="#cb7-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-19"><a href="#cb7-19"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb7-20"><a href="#cb7-20"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb7-21"><a href="#cb7-21"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb7-22"><a href="#cb7-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb7-23"><a href="#cb7-23"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb7-24"><a href="#cb7-24"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb7-25"><a href="#cb7-25"></a>    )</span>
+<span id="cb7-26"><a href="#cb7-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-27"><a href="#cb7-27"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-28"><a href="#cb7-28"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb7-29"><a href="#cb7-29"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-30"><a href="#cb7-30"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb7-31"><a href="#cb7-31"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-32"><a href="#cb7-32"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb7-33"><a href="#cb7-33"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-34"><a href="#cb7-34"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb7-35"><a href="#cb7-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-36"><a href="#cb7-36"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb7-37"><a href="#cb7-37"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb7-38"><a href="#cb7-38"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb7-40"><a href="#cb7-40"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb7-41"><a href="#cb7-41"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb7-42"><a href="#cb7-42"></a>    )</span>
+<span id="cb7-43"><a href="#cb7-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-44"><a href="#cb7-44"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-45"><a href="#cb7-45"></a>  <span class="fu">append_varlabels</span>(adae, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb7-46"><a href="#cb7-46"></a></span>
+<span id="cb7-47"><a href="#cb7-47"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb7-48"><a href="#cb7-48"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb7-49"><a href="#cb7-49"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb7-50"><a href="#cb7-50"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb7-51"><a href="#cb7-51"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb7-52"><a href="#cb7-52"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-53"><a href="#cb7-53"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb7-54"><a href="#cb7-54"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb7-55"><a href="#cb7-55"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb7-56"><a href="#cb7-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-57"><a href="#cb7-57"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb7-58"><a href="#cb7-58"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb7-59"><a href="#cb7-59"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb7-60"><a href="#cb7-60"></a>  )</span>
+<span id="cb7-61"><a href="#cb7-61"></a></span>
+<span id="cb7-62"><a href="#cb7-62"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                                               
+  High Level Term                                               A: Drug X    B: Placebo   C: Combination
+    MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event       100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Overall total number of events                                     502          480            604      
+cl A.1                                                                                                  
+  Total number of patients with at least one adverse event     68 (50.7%)    58 (43.3%)     76 (57.6%)  
+  Total number of events                                           115           99            137      
+  hlt A.1.1.1                                                                                           
+    Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+    Total number of events                                         115           99            137      
+    dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)  
+    dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                                                  
+  Total number of patients with at least one adverse event     62 (46.3%)    56 (41.8%)     74 (56.1%)  
+  Total number of events                                           102          106            127      
+  hlt B.2.2.3                                                                                           
+    Total number of patients with at least one adverse event   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+    Total number of events                                         50            55             68      
+    dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  hlt B.2.1.2                                                                                           
+    Total number of patients with at least one adverse event   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+    Total number of events                                         52            51             59      
+    dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                                                  
+  Total number of patients with at least one adverse event     64 (47.8%)    54 (40.3%)     68 (51.5%)  
+  Total number of events                                           106           84            114      
+  hlt D.1.1.1                                                                                           
+    Total number of patients with at least one adverse event   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+    Total number of events                                         52            40             64      
+    dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  hlt D.1.1.4                                                                                           
+    Total number of patients with at least one adverse event   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+    Total number of events                                         54            44             50      
+    dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                                                  
+  Total number of patients with at least one adverse event     37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  Total number of events                                           49            57             65      
+  hlt D.2.1.5                                                                                           
+    Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+    Total number of events                                         49            57             65      
+    dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                                                  
+  Total number of patients with at least one adverse event     28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  Total number of events                                           39            40             57      
+  hlt C.2.1.2                                                                                           
+    Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+    Total number of events                                         39            40             57      
+    dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                                                  
+  Total number of patients with at least one adverse event     38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  Total number of events                                           44            43             50      
+  hlt B.1.1.1                                                                                           
+    Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+    Total number of events                                         44            43             50      
+    dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                                                  
+  Total number of patients with at least one adverse event     36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  Total number of events                                           47            51             54      
+  hlt C.1.1.1                                                                                           
+    Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+    Total number of events                                         47            51             54      
+    dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant5_6566326d7ba1de68fb2130ec806855b2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb9-4"><a href="#cb9-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb9-5"><a href="#cb9-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb9-6"><a href="#cb9-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb9-7"><a href="#cb9-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb9-8"><a href="#cb9-8"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb9-9"><a href="#cb9-9"></a>    ),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb9-11"><a href="#cb9-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>)</span>
+<span id="cb9-14"><a href="#cb9-14"></a></span>
+<span id="cb9-15"><a href="#cb9-15"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb9-16"><a href="#cb9-16"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb9-17"><a href="#cb9-17"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb9-18"><a href="#cb9-18"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb9-19"><a href="#cb9-19"></a>  )</span>
+<span id="cb9-20"><a href="#cb9-20"></a></span>
+<span id="cb9-21"><a href="#cb9-21"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA Preferred Term                                       A: Drug X    B: Placebo   C: Combination
+                                                             (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+Total number of events                                         502          480            604      
+dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)     50 (37.9%)  
+dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)     52 (39.4%)  
+dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)     45 (34.1%)  
+dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)     42 (31.8%)  
+dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)     46 (34.8%)  
+dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)     46 (34.8%)  
+dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)     48 (36.4%)  
+dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)     40 (30.3%)  
+dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)     36 (27.3%)  
+dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant6_71287b45f782f4c7c881b45d2a0bc9cb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>adae_5 <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ACTARM <span class="sc">!=</span> <span class="st">"C: Combination"</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb11-6"><a href="#cb11-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb11-7"><a href="#cb11-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb11-8"><a href="#cb11-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb11-10"><a href="#cb11-10"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb11-11"><a href="#cb11-11"></a>    )</span>
+<span id="cb11-12"><a href="#cb11-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-13"><a href="#cb11-13"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-14"><a href="#cb11-14"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-15"><a href="#cb11-15"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-16"><a href="#cb11-16"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb11-17"><a href="#cb11-17"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb11-18"><a href="#cb11-18"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-19"><a href="#cb11-19"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb11-20"><a href="#cb11-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-21"><a href="#cb11-21"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb11-22"><a href="#cb11-22"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb11-23"><a href="#cb11-23"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb11-24"><a href="#cb11-24"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb11-25"><a href="#cb11-25"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb11-26"><a href="#cb11-26"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb11-27"><a href="#cb11-27"></a>    )</span>
+<span id="cb11-28"><a href="#cb11-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-29"><a href="#cb11-29"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)) <span class="sc">%&gt;%</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb11-31"><a href="#cb11-31"></a></span>
+<span id="cb11-32"><a href="#cb11-32"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae_5, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb11-33"><a href="#cb11-33"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-34"><a href="#cb11-34"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb11-36"><a href="#cb11-36"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb11-37"><a href="#cb11-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb11-41"><a href="#cb11-41"></a>  )</span>
+<span id="cb11-42"><a href="#cb11-42"></a></span>
+<span id="cb11-43"><a href="#cb11-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                     A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term                                        (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     100 (74.6%)   98 (73.1%)         0       
+Overall total number of events                                   502          480             0       
+cl A.1                                                                                                
+  Total number of patients with at least one adverse event   68 (50.7%)    58 (43.3%)         0       
+  Total number of events                                         115           99             0       
+  dcd A.1.1.1.2                                              41 (30.6%)    39 (29.1%)         0       
+  dcd A.1.1.1.1                                              45 (33.6%)    31 (23.1%)         0       
+cl B.2                                                                                                
+  Total number of patients with at least one adverse event   62 (46.3%)    56 (41.8%)         0       
+  Total number of events                                         102          106             0       
+  dcd B.2.2.3.1                                              38 (28.4%)    40 (29.9%)         0       
+  dcd B.2.1.2.1                                              39 (29.1%)    34 (25.4%)         0       
+cl D.1                                                                                                
+  Total number of patients with at least one adverse event   64 (47.8%)    54 (40.3%)         0       
+  Total number of events                                         106           84             0       
+  dcd D.1.1.1.1                                              42 (31.3%)    32 (23.9%)         0       
+  dcd D.1.1.4.2                                              38 (28.4%)    34 (25.4%)         0       
+cl D.2                                                                                                
+  Total number of patients with at least one adverse event   37 (27.6%)    46 (34.3%)         0       
+  Total number of events                                         49            57             0       
+  dcd D.2.1.5.3                                              37 (27.6%)    46 (34.3%)         0       
+cl B.1                                                                                                
+  Total number of patients with at least one adverse event   38 (28.4%)    37 (27.6%)         0       
+  Total number of events                                         44            43             0       
+  dcd B.1.1.1.1                                              38 (28.4%)    37 (27.6%)         0       
+cl C.1                                                                                                
+  Total number of patients with at least one adverse event   36 (26.9%)    34 (25.4%)         0       
+  Total number of events                                         47            51             0       
+  dcd C.1.1.1.3                                              36 (26.9%)    34 (25.4%)         0       
+cl C.2                                                                                                
+  Total number of patients with at least one adverse event   28 (20.9%)    36 (26.9%)         0       
+  Total number of events                                         39            40             0       
+  dcd C.2.1.2.1                                              28 (20.9%)    36 (26.9%)         0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;result_v7&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant7_59e67bc71a7d4dca4edcefe6f28d5706">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-3"><a href="#cb13-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb13-4"><a href="#cb13-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb13-5"><a href="#cb13-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb13-6"><a href="#cb13-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb13-7"><a href="#cb13-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb13-8"><a href="#cb13-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb13-9"><a href="#cb13-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb13-10"><a href="#cb13-10"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-12"><a href="#cb13-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb13-13"><a href="#cb13-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb13-14"><a href="#cb13-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb13-15"><a href="#cb13-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb13-16"><a href="#cb13-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-17"><a href="#cb13-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb13-18"><a href="#cb13-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb13-19"><a href="#cb13-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb13-20"><a href="#cb13-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-21"><a href="#cb13-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb13-22"><a href="#cb13-22"></a></span>
+<span id="cb13-23"><a href="#cb13-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb13-24"><a href="#cb13-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb13-25"><a href="#cb13-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb13-26"><a href="#cb13-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb13-27"><a href="#cb13-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb13-28"><a href="#cb13-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-29"><a href="#cb13-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb13-30"><a href="#cb13-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb13-31"><a href="#cb13-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb13-32"><a href="#cb13-32"></a>  )</span>
+<span id="cb13-33"><a href="#cb13-33"></a></span>
+<span id="cb13-34"><a href="#cb13-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb13-35"><a href="#cb13-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb13-36"><a href="#cb13-36"></a></span>
+<span id="cb13-37"><a href="#cb13-37"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb13-38"><a href="#cb13-38"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb13-39"><a href="#cb13-39"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb13-40"><a href="#cb13-40"></a>)</span>
+<span id="cb13-41"><a href="#cb13-41"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb13-42"><a href="#cb13-42"></a></span>
+<span id="cb13-43"><a href="#cb13-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  
+cl B.1                                                              
+  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  
+cl C.1                                                              
+  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-test="{&quot;result_v8&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant8_c05649197a5822fa0927f73e49710997">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-4"><a href="#cb15-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb15-5"><a href="#cb15-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-6"><a href="#cb15-6"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-7"><a href="#cb15-7"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-8"><a href="#cb15-8"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-9"><a href="#cb15-9"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-11"><a href="#cb15-11"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-12"><a href="#cb15-12"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-13"><a href="#cb15-13"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb15-14"><a href="#cb15-14"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-16"><a href="#cb15-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-17"><a href="#cb15-17"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb15-18"><a href="#cb15-18"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-19"><a href="#cb15-19"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-20"><a href="#cb15-20"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-21"><a href="#cb15-21"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-22"><a href="#cb15-22"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb15-23"><a href="#cb15-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-24"><a href="#cb15-24"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-25"><a href="#cb15-25"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-26"><a href="#cb15-26"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb15-27"><a href="#cb15-27"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb15-28"><a href="#cb15-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-29"><a href="#cb15-29"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-30"><a href="#cb15-30"></a>  <span class="fu">append_varlabels</span>(adae, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb15-31"><a href="#cb15-31"></a></span>
+<span id="cb15-32"><a href="#cb15-32"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb15-33"><a href="#cb15-33"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-34"><a href="#cb15-34"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-35"><a href="#cb15-35"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb15-36"><a href="#cb15-36"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb15-37"><a href="#cb15-37"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-38"><a href="#cb15-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-39"><a href="#cb15-39"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-40"><a href="#cb15-40"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb15-41"><a href="#cb15-41"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb15-42"><a href="#cb15-42"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-44"><a href="#cb15-44"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-45"><a href="#cb15-45"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb15-46"><a href="#cb15-46"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb15-47"><a href="#cb15-47"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-48"><a href="#cb15-48"></a>  )</span>
+<span id="cb15-49"><a href="#cb15-49"></a></span>
+<span id="cb15-50"><a href="#cb15-50"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb15-51"><a href="#cb15-51"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb15-52"><a href="#cb15-52"></a></span>
+<span id="cb15-53"><a href="#cb15-53"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb15-54"><a href="#cb15-54"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb15-55"><a href="#cb15-55"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb15-56"><a href="#cb15-56"></a>)</span>
+<span id="cb15-57"><a href="#cb15-57"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb15-58"><a href="#cb15-58"></a></span>
+<span id="cb15-59"><a href="#cb15-59"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                           
+  High Level Term           A: Drug X    B: Placebo   C: Combination
+    MedDRA Preferred Term    (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  hlt A.1.1.1                                                       
+    dcd A.1.1.1.1           45 (33.6%)   31 (23.1%)     52 (39.4%)  
+    dcd A.1.1.1.2           41 (30.6%)   39 (29.1%)     42 (31.8%)  
+cl B.2                                                              
+  hlt B.2.2.3                                                       
+    dcd B.2.2.3.1           38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  hlt B.2.1.2                                                       
+    dcd B.2.1.2.1           39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  hlt D.1.1.1                                                       
+    dcd D.1.1.1.1           42 (31.3%)   32 (23.9%)     46 (34.8%)  
+  hlt D.1.1.4                                                       
+    dcd D.1.1.4.2           38 (28.4%)   34 (25.4%)     40 (30.3%)  
+cl D.2                                                              
+  hlt D.2.1.5                                                       
+    dcd D.2.1.5.3           37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  hlt C.2.1.2                                                       
+    dcd C.2.1.2.1           28 (20.9%)   36 (26.9%)     48 (36.4%)  
+cl B.1                                                              
+  hlt B.1.1.1                                                       
+    dcd B.1.1.1.1           38 (28.4%)   37 (27.6%)     36 (27.3%)  
+cl C.1                                                              
+  hlt C.1.1.1                                                       
+    dcd C.1.1.1.3           36 (26.9%)   34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<div class="cell" data-test="{&quot;result_v9&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant9_705597896465ce0924eaf8ba12521445">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb17-2"><a href="#cb17-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb17-3"><a href="#cb17-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb17-4"><a href="#cb17-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb17-5"><a href="#cb17-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb17-6"><a href="#cb17-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb17-7"><a href="#cb17-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb17-8"><a href="#cb17-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb17-9"><a href="#cb17-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb17-10"><a href="#cb17-10"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb17-12"><a href="#cb17-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb17-13"><a href="#cb17-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb17-14"><a href="#cb17-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb17-15"><a href="#cb17-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb17-16"><a href="#cb17-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb17-17"><a href="#cb17-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb17-18"><a href="#cb17-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb17-19"><a href="#cb17-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb17-20"><a href="#cb17-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb17-21"><a href="#cb17-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb17-22"><a href="#cb17-22"></a></span>
+<span id="cb17-23"><a href="#cb17-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb17-24"><a href="#cb17-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb17-25"><a href="#cb17-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb17-26"><a href="#cb17-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb17-27"><a href="#cb17-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb17-28"><a href="#cb17-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb17-29"><a href="#cb17-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb17-30"><a href="#cb17-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb17-31"><a href="#cb17-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb17-32"><a href="#cb17-32"></a>  )</span>
+<span id="cb17-33"><a href="#cb17-33"></a></span>
+<span id="cb17-34"><a href="#cb17-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb17-35"><a href="#cb17-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb17-36"><a href="#cb17-36"></a></span>
+<span id="cb17-37"><a href="#cb17-37"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb17-38"><a href="#cb17-38"></a>  <span class="at">atleast =</span> <span class="fl">0.10</span>,</span>
+<span id="cb17-39"><a href="#cb17-39"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb17-40"><a href="#cb17-40"></a>)</span>
+<span id="cb17-41"><a href="#cb17-41"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb17-42"><a href="#cb17-42"></a></span>
+<span id="cb17-43"><a href="#cb17-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  
+cl B.1                                                              
+  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  
+cl C.1                                                              
+  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-test="{&quot;result_v10&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant10_ea211df291a58f6e0c13dfd7154a941f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb19"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb19-1"><a href="#cb19-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb19-2"><a href="#cb19-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb19-3"><a href="#cb19-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb19-4"><a href="#cb19-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb19-5"><a href="#cb19-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb19-6"><a href="#cb19-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb19-7"><a href="#cb19-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb19-8"><a href="#cb19-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb19-9"><a href="#cb19-9"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS),</span>
+<span id="cb19-10"><a href="#cb19-10"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb19-11"><a href="#cb19-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb19-12"><a href="#cb19-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb19-13"><a href="#cb19-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb19-14"><a href="#cb19-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb19-15"><a href="#cb19-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb19-16"><a href="#cb19-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb19-17"><a href="#cb19-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb19-18"><a href="#cb19-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb19-19"><a href="#cb19-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb19-20"><a href="#cb19-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb19-21"><a href="#cb19-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb19-22"><a href="#cb19-22"></a></span>
+<span id="cb19-23"><a href="#cb19-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb19-24"><a href="#cb19-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb19-25"><a href="#cb19-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb19-26"><a href="#cb19-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb19-27"><a href="#cb19-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb19-28"><a href="#cb19-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb19-29"><a href="#cb19-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb19-30"><a href="#cb19-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb19-31"><a href="#cb19-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb19-32"><a href="#cb19-32"></a>  )</span>
+<span id="cb19-33"><a href="#cb19-33"></a></span>
+<span id="cb19-34"><a href="#cb19-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb19-35"><a href="#cb19-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb19-36"><a href="#cb19-36"></a></span>
+<span id="cb19-37"><a href="#cb19-37"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_count_in_any_col</span>(</span>
+<span id="cb19-38"><a href="#cb19-38"></a>  <span class="at">atleast =</span> <span class="dv">3</span>,</span>
+<span id="cb19-39"><a href="#cb19-39"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb19-40"><a href="#cb19-40"></a>)</span>
+<span id="cb19-41"><a href="#cb19-41"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb19-42"><a href="#cb19-42"></a></span>
+<span id="cb19-43"><a href="#cb19-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  
+cl B.1                                                              
+  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  
+cl C.1                                                              
+  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<div class="cell" data-test="{&quot;result_v11&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant11_894842dba0857292500caca61157dc17">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb21"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb21-1"><a href="#cb21-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-2"><a href="#cb21-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-3"><a href="#cb21-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb21-4"><a href="#cb21-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb21-5"><a href="#cb21-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-6"><a href="#cb21-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb21-7"><a href="#cb21-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb21-8"><a href="#cb21-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb21-9"><a href="#cb21-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb21-10"><a href="#cb21-10"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb21-11"><a href="#cb21-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-12"><a href="#cb21-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb21-13"><a href="#cb21-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb21-14"><a href="#cb21-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb21-15"><a href="#cb21-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb21-16"><a href="#cb21-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-17"><a href="#cb21-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb21-18"><a href="#cb21-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb21-19"><a href="#cb21-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb21-20"><a href="#cb21-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-21"><a href="#cb21-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb21-22"><a href="#cb21-22"></a></span>
+<span id="cb21-23"><a href="#cb21-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb21-24"><a href="#cb21-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb21-25"><a href="#cb21-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb21-26"><a href="#cb21-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb21-27"><a href="#cb21-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb21-28"><a href="#cb21-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-29"><a href="#cb21-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb21-30"><a href="#cb21-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb21-31"><a href="#cb21-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb21-32"><a href="#cb21-32"></a>  )</span>
+<span id="cb21-33"><a href="#cb21-33"></a></span>
+<span id="cb21-34"><a href="#cb21-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb21-35"><a href="#cb21-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb21-36"><a href="#cb21-36"></a></span>
+<span id="cb21-37"><a href="#cb21-37"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(</span>
+<span id="cb21-38"><a href="#cb21-38"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb21-39"><a href="#cb21-39"></a>  <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM)</span>
+<span id="cb21-40"><a href="#cb21-40"></a>)</span>
+<span id="cb21-41"><a href="#cb21-41"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb21-42"><a href="#cb21-42"></a></span>
+<span id="cb21-43"><a href="#cb21-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-12" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-12-tab">
+<div class="cell" data-test="{&quot;result_v12&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant12_86b4b05b1486d730439b562f4bb04b07">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb23"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb23-1"><a href="#cb23-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb23-2"><a href="#cb23-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb23-3"><a href="#cb23-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb23-4"><a href="#cb23-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb23-5"><a href="#cb23-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb23-6"><a href="#cb23-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb23-7"><a href="#cb23-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb23-8"><a href="#cb23-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb23-9"><a href="#cb23-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb23-10"><a href="#cb23-10"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb23-11"><a href="#cb23-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb23-12"><a href="#cb23-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb23-13"><a href="#cb23-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb23-14"><a href="#cb23-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb23-15"><a href="#cb23-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb23-16"><a href="#cb23-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb23-17"><a href="#cb23-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb23-18"><a href="#cb23-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb23-19"><a href="#cb23-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb23-20"><a href="#cb23-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb23-21"><a href="#cb23-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb23-22"><a href="#cb23-22"></a></span>
+<span id="cb23-23"><a href="#cb23-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb23-24"><a href="#cb23-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb23-25"><a href="#cb23-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb23-26"><a href="#cb23-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb23-27"><a href="#cb23-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb23-28"><a href="#cb23-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb23-29"><a href="#cb23-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb23-30"><a href="#cb23-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb23-31"><a href="#cb23-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb23-32"><a href="#cb23-32"></a>  )</span>
+<span id="cb23-33"><a href="#cb23-33"></a></span>
+<span id="cb23-34"><a href="#cb23-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb23-35"><a href="#cb23-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb23-36"><a href="#cb23-36"></a></span>
+<span id="cb23-37"><a href="#cb23-37"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_cols</span>(</span>
+<span id="cb23-38"><a href="#cb23-38"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb23-39"><a href="#cb23-39"></a>  <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>)</span>
+<span id="cb23-40"><a href="#cb23-40"></a>)</span>
+<span id="cb23-41"><a href="#cb23-41"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb23-42"><a href="#cb23-42"></a></span>
+<span id="cb23-43"><a href="#cb23-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2             41 (30.6%)   39 (29.1%)     42 (31.8%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2             38 (28.4%)   34 (25.4%)     40 (30.3%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  
+cl B.1                                                              
+  dcd B.1.1.1.1             38 (28.4%)   37 (27.6%)     36 (27.3%)  
+cl C.1                                                              
+  dcd C.1.1.1.3             36 (26.9%)   34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-13" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-13-tab">
+<div class="cell" data-test="{&quot;result_v13&quot;:&quot;result&quot;}" data-hash="aet02_cache/html/variant13_430d85396f8c5e6cc04fe373050bcc10">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb25"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb25-1"><a href="#cb25-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb25-2"><a href="#cb25-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb25-3"><a href="#cb25-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb25-4"><a href="#cb25-4"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb25-5"><a href="#cb25-5"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb25-6"><a href="#cb25-6"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb25-7"><a href="#cb25-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb25-8"><a href="#cb25-8"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb25-9"><a href="#cb25-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb25-10"><a href="#cb25-10"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb25-11"><a href="#cb25-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb25-12"><a href="#cb25-12"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb25-13"><a href="#cb25-13"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb25-14"><a href="#cb25-14"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb25-15"><a href="#cb25-15"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb25-16"><a href="#cb25-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb25-17"><a href="#cb25-17"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb25-18"><a href="#cb25-18"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb25-19"><a href="#cb25-19"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb25-20"><a href="#cb25-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb25-21"><a href="#cb25-21"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb25-22"><a href="#cb25-22"></a></span>
+<span id="cb25-23"><a href="#cb25-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb25-24"><a href="#cb25-24"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb25-25"><a href="#cb25-25"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb25-26"><a href="#cb25-26"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb25-27"><a href="#cb25-27"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb25-28"><a href="#cb25-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb25-29"><a href="#cb25-29"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb25-30"><a href="#cb25-30"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb25-31"><a href="#cb25-31"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb25-32"><a href="#cb25-32"></a>  )</span>
+<span id="cb25-33"><a href="#cb25-33"></a></span>
+<span id="cb25-34"><a href="#cb25-34"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb25-35"><a href="#cb25-35"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb25-36"><a href="#cb25-36"></a></span>
+<span id="cb25-37"><a href="#cb25-37"></a>row_condition1 <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>))</span>
+<span id="cb25-38"><a href="#cb25-38"></a>row_condition2 <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))</span>
+<span id="cb25-39"><a href="#cb25-39"></a>row_condition <span class="ot">&lt;-</span> row_condition1 <span class="sc">|</span> row_condition2</span>
+<span id="cb25-40"><a href="#cb25-40"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb25-41"><a href="#cb25-41"></a></span>
+<span id="cb25-42"><a href="#cb25-42"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class   A: Drug X    B: Placebo   C: Combination
+  MedDRA Preferred Term      (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————
+cl A.1                                                              
+  dcd A.1.1.1.1             45 (33.6%)   31 (23.1%)     52 (39.4%)  
+cl B.2                                                              
+  dcd B.2.2.3.1             38 (28.4%)   40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1             39 (29.1%)   34 (25.4%)     46 (34.8%)  
+cl D.1                                                              
+  dcd D.1.1.1.1             42 (31.3%)   32 (23.9%)     46 (34.8%)  
+cl D.2                                                              
+  dcd D.2.1.5.3             37 (27.6%)   46 (34.3%)     50 (37.9%)  
+cl C.2                                                              
+  dcd C.2.1.2.1             28 (20.9%)   36 (26.9%)     48 (36.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-14" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-14-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet02_cache/html/teal_d8dbbf7fcda858fd190bfc3bfa8b6f8c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb27"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb27-1"><a href="#cb27-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb27-2"><a href="#cb27-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb27-3"><a href="#cb27-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb27-4"><a href="#cb27-4"></a></span>
+<span id="cb27-5"><a href="#cb27-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb27-6"><a href="#cb27-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb27-7"><a href="#cb27-7"></a></span>
+<span id="cb27-8"><a href="#cb27-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb27-9"><a href="#cb27-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb27-10"><a href="#cb27-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb27-11"><a href="#cb27-11"></a></span>
+<span id="cb27-12"><a href="#cb27-12"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb27-13"><a href="#cb27-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb27-14"><a href="#cb27-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb27-15"><a href="#cb27-15"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb27-16"><a href="#cb27-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-17"><a href="#cb27-17"></a>  ),</span>
+<span id="cb27-18"><a href="#cb27-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb27-19"><a href="#cb27-19"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb27-20"><a href="#cb27-20"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb27-21"><a href="#cb27-21"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb27-22"><a href="#cb27-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb27-23"><a href="#cb27-23"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb27-24"><a href="#cb27-24"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb27-25"><a href="#cb27-25"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb27-26"><a href="#cb27-26"></a>      ),</span>
+<span id="cb27-27"><a href="#cb27-27"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb27-28"><a href="#cb27-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb27-29"><a href="#cb27-29"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb27-30"><a href="#cb27-30"></a>      ),</span>
+<span id="cb27-31"><a href="#cb27-31"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb27-32"><a href="#cb27-32"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb27-33"><a href="#cb27-33"></a>    )</span>
+<span id="cb27-34"><a href="#cb27-34"></a>  )</span>
+<span id="cb27-35"><a href="#cb27-35"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:21:44.2056 pid:11194 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb29"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb29-1"><a href="#cb29-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-15" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-15-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet02_cache/html/sessioninfo_2175068ff937e4f76fe3338f23f3416e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb30"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb30-1"><a href="#cb30-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet02_cache/html/snapshot_952467d3ae981af031c2623c00b02578">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb32"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb32-1"><a href="#cb32-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb32-2"><a href="#cb32-2"></a></span>
+<span id="cb32-3"><a href="#cb32-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb32-4"><a href="#cb32-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb32-5"><a href="#cb32-5"></a></span>
+<span id="cb32-6"><a href="#cb32-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb32-7"><a href="#cb32-7"></a></span>
+<span id="cb32-8"><a href="#cb32-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb32-9"><a href="#cb32-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb32-10"><a href="#cb32-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb32-11"><a href="#cb32-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
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+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet01_aesi.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET01_AESI</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet02_smq.html" class="pagination-link">
+        <span class="nav-page-text">AET02_SMQ</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb33" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb33-1"><a href="#cb33-1"></a><span class="co">---</span></span>
+<span id="cb33-2"><a href="#cb33-2"></a><span class="an">title:</span><span class="co"> AET02</span></span>
+<span id="cb33-3"><a href="#cb33-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events</span></span>
+<span id="cb33-4"><a href="#cb33-4"></a><span class="co">---</span></span>
+<span id="cb33-5"><a href="#cb33-5"></a></span>
+<span id="cb33-6"><a href="#cb33-6"></a>------------------------------------------------------------------------</span>
+<span id="cb33-7"><a href="#cb33-7"></a></span>
+<span id="cb33-8"><a href="#cb33-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb33-9"><a href="#cb33-9"></a></span>
+<span id="cb33-10"><a href="#cb33-10"></a>::: panel-tabset</span>
+<span id="cb33-11"><a href="#cb33-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb33-12"><a href="#cb33-12"></a></span>
+<span id="cb33-13"><a href="#cb33-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb33-14"><a href="#cb33-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb33-15"><a href="#cb33-15"></a></span>
+<span id="cb33-16"><a href="#cb33-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb33-17"><a href="#cb33-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb33-18"><a href="#cb33-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb33-19"><a href="#cb33-19"></a></span>
+<span id="cb33-20"><a href="#cb33-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb33-21"><a href="#cb33-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb33-22"><a href="#cb33-22"></a></span>
+<span id="cb33-23"><a href="#cb33-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb33-24"><a href="#cb33-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb33-25"><a href="#cb33-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb33-26"><a href="#cb33-26"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb33-27"><a href="#cb33-27"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb33-28"><a href="#cb33-28"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb33-29"><a href="#cb33-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-30"><a href="#cb33-30"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb33-31"><a href="#cb33-31"></a></span>
+<span id="cb33-32"><a href="#cb33-32"></a><span class="co"># Define the split function</span></span>
+<span id="cb33-33"><a href="#cb33-33"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb33-34"><a href="#cb33-34"></a><span class="in">```</span></span>
+<span id="cb33-35"><a href="#cb33-35"></a></span>
+<span id="cb33-36"><a href="#cb33-36"></a><span class="fu">## Standard Table</span></span>
+<span id="cb33-37"><a href="#cb33-37"></a></span>
+<span id="cb33-38"><a href="#cb33-38"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb33-39"><a href="#cb33-39"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-40"><a href="#cb33-40"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-41"><a href="#cb33-41"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-42"><a href="#cb33-42"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb33-43"><a href="#cb33-43"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-44"><a href="#cb33-44"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-45"><a href="#cb33-45"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-46"><a href="#cb33-46"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-47"><a href="#cb33-47"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb33-48"><a href="#cb33-48"></a>    )</span>
+<span id="cb33-49"><a href="#cb33-49"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-50"><a href="#cb33-50"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-51"><a href="#cb33-51"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-52"><a href="#cb33-52"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-53"><a href="#cb33-53"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-54"><a href="#cb33-54"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-55"><a href="#cb33-55"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-56"><a href="#cb33-56"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-57"><a href="#cb33-57"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-58"><a href="#cb33-58"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-59"><a href="#cb33-59"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-60"><a href="#cb33-60"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-61"><a href="#cb33-61"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-62"><a href="#cb33-62"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-63"><a href="#cb33-63"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb33-64"><a href="#cb33-64"></a>    )</span>
+<span id="cb33-65"><a href="#cb33-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-66"><a href="#cb33-66"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-67"><a href="#cb33-67"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-68"><a href="#cb33-68"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb33-69"><a href="#cb33-69"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-70"><a href="#cb33-70"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-71"><a href="#cb33-71"></a></span>
+<span id="cb33-72"><a href="#cb33-72"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb33-73"><a href="#cb33-73"></a><span class="in">```</span></span>
+<span id="cb33-74"><a href="#cb33-74"></a></span>
+<span id="cb33-75"><a href="#cb33-75"></a>The variable <span class="in">`result`</span> corresponds to the adverse events table.</span>
+<span id="cb33-76"><a href="#cb33-76"></a>However, it includes many empty rows accounting for events which were not reported.</span>
+<span id="cb33-77"><a href="#cb33-77"></a>The table can be post-processed to prune empty rows and to sort rows, for example by occurrence.</span>
+<span id="cb33-78"><a href="#cb33-78"></a></span>
+<span id="cb33-79"><a href="#cb33-79"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb33-80"><a href="#cb33-80"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span></span>
+<span id="cb33-81"><a href="#cb33-81"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-82"><a href="#cb33-82"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-83"><a href="#cb33-83"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-84"><a href="#cb33-84"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-85"><a href="#cb33-85"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-86"><a href="#cb33-86"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-87"><a href="#cb33-87"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-88"><a href="#cb33-88"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-89"><a href="#cb33-89"></a>  )</span>
+<span id="cb33-90"><a href="#cb33-90"></a></span>
+<span id="cb33-91"><a href="#cb33-91"></a>result</span>
+<span id="cb33-92"><a href="#cb33-92"></a><span class="in">```</span></span>
+<span id="cb33-93"><a href="#cb33-93"></a></span>
+<span id="cb33-94"><a href="#cb33-94"></a><span class="fu">## Table with &lt;br/&gt; Event Totals</span></span>
+<span id="cb33-95"><a href="#cb33-95"></a></span>
+<span id="cb33-96"><a href="#cb33-96"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb33-97"><a href="#cb33-97"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-98"><a href="#cb33-98"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-99"><a href="#cb33-99"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-100"><a href="#cb33-100"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb33-101"><a href="#cb33-101"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-102"><a href="#cb33-102"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-103"><a href="#cb33-103"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-104"><a href="#cb33-104"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-105"><a href="#cb33-105"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb33-106"><a href="#cb33-106"></a>    )</span>
+<span id="cb33-107"><a href="#cb33-107"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-108"><a href="#cb33-108"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-109"><a href="#cb33-109"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-110"><a href="#cb33-110"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-111"><a href="#cb33-111"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-112"><a href="#cb33-112"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-113"><a href="#cb33-113"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-114"><a href="#cb33-114"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-115"><a href="#cb33-115"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-116"><a href="#cb33-116"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-117"><a href="#cb33-117"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-118"><a href="#cb33-118"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb33-119"><a href="#cb33-119"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-120"><a href="#cb33-120"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-121"><a href="#cb33-121"></a>    )</span>
+<span id="cb33-122"><a href="#cb33-122"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-123"><a href="#cb33-123"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb33-124"><a href="#cb33-124"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb33-125"><a href="#cb33-125"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb33-126"><a href="#cb33-126"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb33-127"><a href="#cb33-127"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb33-128"><a href="#cb33-128"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb33-129"><a href="#cb33-129"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of events"</span>),</span>
+<span id="cb33-130"><a href="#cb33-130"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="sc">-</span>1L)</span>
+<span id="cb33-131"><a href="#cb33-131"></a>  )</span>
+<span id="cb33-132"><a href="#cb33-132"></a></span>
+<span id="cb33-133"><a href="#cb33-133"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span> <span class="co"># col_count = c(table(adsl$ACTARM), sum(table(adsl$ACTARM)))</span></span>
+<span id="cb33-134"><a href="#cb33-134"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-135"><a href="#cb33-135"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-136"><a href="#cb33-136"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-137"><a href="#cb33-137"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-138"><a href="#cb33-138"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-139"><a href="#cb33-139"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-140"><a href="#cb33-140"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-141"><a href="#cb33-141"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-142"><a href="#cb33-142"></a>  )</span>
+<span id="cb33-143"><a href="#cb33-143"></a></span>
+<span id="cb33-144"><a href="#cb33-144"></a>result</span>
+<span id="cb33-145"><a href="#cb33-145"></a><span class="in">```</span></span>
+<span id="cb33-146"><a href="#cb33-146"></a></span>
+<span id="cb33-147"><a href="#cb33-147"></a><span class="fu">## Table with &lt;br/&gt; High-Level Term</span></span>
+<span id="cb33-148"><a href="#cb33-148"></a></span>
+<span id="cb33-149"><a href="#cb33-149"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb33-150"><a href="#cb33-150"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-151"><a href="#cb33-151"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-152"><a href="#cb33-152"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb33-153"><a href="#cb33-153"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-154"><a href="#cb33-154"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-155"><a href="#cb33-155"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-156"><a href="#cb33-156"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-157"><a href="#cb33-157"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb33-158"><a href="#cb33-158"></a>    )</span>
+<span id="cb33-159"><a href="#cb33-159"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-160"><a href="#cb33-160"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-161"><a href="#cb33-161"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-162"><a href="#cb33-162"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-163"><a href="#cb33-163"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-164"><a href="#cb33-164"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-165"><a href="#cb33-165"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-166"><a href="#cb33-166"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-167"><a href="#cb33-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-168"><a href="#cb33-168"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-169"><a href="#cb33-169"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-170"><a href="#cb33-170"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-171"><a href="#cb33-171"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-172"><a href="#cb33-172"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-173"><a href="#cb33-173"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb33-174"><a href="#cb33-174"></a>    )</span>
+<span id="cb33-175"><a href="#cb33-175"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-176"><a href="#cb33-176"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-177"><a href="#cb33-177"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb33-178"><a href="#cb33-178"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-179"><a href="#cb33-179"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb33-180"><a href="#cb33-180"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-181"><a href="#cb33-181"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-182"><a href="#cb33-182"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-183"><a href="#cb33-183"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb33-184"><a href="#cb33-184"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-185"><a href="#cb33-185"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-186"><a href="#cb33-186"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-187"><a href="#cb33-187"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-188"><a href="#cb33-188"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-189"><a href="#cb33-189"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-190"><a href="#cb33-190"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb33-191"><a href="#cb33-191"></a>    )</span>
+<span id="cb33-192"><a href="#cb33-192"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-193"><a href="#cb33-193"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)) <span class="sc">%&gt;%</span></span>
+<span id="cb33-194"><a href="#cb33-194"></a>  <span class="fu">append_varlabels</span>(adae, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb33-195"><a href="#cb33-195"></a></span>
+<span id="cb33-196"><a href="#cb33-196"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-197"><a href="#cb33-197"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-198"><a href="#cb33-198"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-199"><a href="#cb33-199"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-200"><a href="#cb33-200"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-201"><a href="#cb33-201"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-202"><a href="#cb33-202"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-203"><a href="#cb33-203"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb33-204"><a href="#cb33-204"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-205"><a href="#cb33-205"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-206"><a href="#cb33-206"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-207"><a href="#cb33-207"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-208"><a href="#cb33-208"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-209"><a href="#cb33-209"></a>  )</span>
+<span id="cb33-210"><a href="#cb33-210"></a></span>
+<span id="cb33-211"><a href="#cb33-211"></a>result</span>
+<span id="cb33-212"><a href="#cb33-212"></a><span class="in">```</span></span>
+<span id="cb33-213"><a href="#cb33-213"></a></span>
+<span id="cb33-214"><a href="#cb33-214"></a><span class="fu">## Table with Preferred &lt;br/&gt; Terms Only</span></span>
+<span id="cb33-215"><a href="#cb33-215"></a></span>
+<span id="cb33-216"><a href="#cb33-216"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb33-217"><a href="#cb33-217"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-218"><a href="#cb33-218"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-219"><a href="#cb33-219"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb33-220"><a href="#cb33-220"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-221"><a href="#cb33-221"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-222"><a href="#cb33-222"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-223"><a href="#cb33-223"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-224"><a href="#cb33-224"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb33-225"><a href="#cb33-225"></a>    ),</span>
+<span id="cb33-226"><a href="#cb33-226"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb33-227"><a href="#cb33-227"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-228"><a href="#cb33-228"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-229"><a href="#cb33-229"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>)</span>
+<span id="cb33-230"><a href="#cb33-230"></a></span>
+<span id="cb33-231"><a href="#cb33-231"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-232"><a href="#cb33-232"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-233"><a href="#cb33-233"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-234"><a href="#cb33-234"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-235"><a href="#cb33-235"></a>  )</span>
+<span id="cb33-236"><a href="#cb33-236"></a></span>
+<span id="cb33-237"><a href="#cb33-237"></a>result</span>
+<span id="cb33-238"><a href="#cb33-238"></a><span class="in">```</span></span>
+<span id="cb33-239"><a href="#cb33-239"></a></span>
+<span id="cb33-240"><a href="#cb33-240"></a><span class="fu">## Table with Fill-In of &lt;br/&gt; Treatment Groups</span></span>
+<span id="cb33-241"><a href="#cb33-241"></a></span>
+<span id="cb33-242"><a href="#cb33-242"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb33-243"><a href="#cb33-243"></a>adae_5 <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(ACTARM <span class="sc">!=</span> <span class="st">"C: Combination"</span>)</span>
+<span id="cb33-244"><a href="#cb33-244"></a></span>
+<span id="cb33-245"><a href="#cb33-245"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-246"><a href="#cb33-246"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-247"><a href="#cb33-247"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb33-248"><a href="#cb33-248"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-249"><a href="#cb33-249"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-250"><a href="#cb33-250"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-251"><a href="#cb33-251"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-252"><a href="#cb33-252"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb33-253"><a href="#cb33-253"></a>    )</span>
+<span id="cb33-254"><a href="#cb33-254"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-255"><a href="#cb33-255"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-256"><a href="#cb33-256"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-257"><a href="#cb33-257"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-258"><a href="#cb33-258"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-259"><a href="#cb33-259"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-260"><a href="#cb33-260"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-261"><a href="#cb33-261"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-262"><a href="#cb33-262"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-263"><a href="#cb33-263"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-264"><a href="#cb33-264"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-265"><a href="#cb33-265"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb33-266"><a href="#cb33-266"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb33-267"><a href="#cb33-267"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb33-268"><a href="#cb33-268"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb33-269"><a href="#cb33-269"></a>    )</span>
+<span id="cb33-270"><a href="#cb33-270"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-271"><a href="#cb33-271"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)) <span class="sc">%&gt;%</span></span>
+<span id="cb33-272"><a href="#cb33-272"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-273"><a href="#cb33-273"></a></span>
+<span id="cb33-274"><a href="#cb33-274"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae_5, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-275"><a href="#cb33-275"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-276"><a href="#cb33-276"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-277"><a href="#cb33-277"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-278"><a href="#cb33-278"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-279"><a href="#cb33-279"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-280"><a href="#cb33-280"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-281"><a href="#cb33-281"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-282"><a href="#cb33-282"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-283"><a href="#cb33-283"></a>  )</span>
+<span id="cb33-284"><a href="#cb33-284"></a></span>
+<span id="cb33-285"><a href="#cb33-285"></a>result</span>
+<span id="cb33-286"><a href="#cb33-286"></a><span class="in">```</span></span>
+<span id="cb33-287"><a href="#cb33-287"></a></span>
+<span id="cb33-288"><a href="#cb33-288"></a><span class="fu">## Table of AEs with an Incidence Rate &lt;br/&gt; $\geq$ 5% in Any Treatment Group (subsetting &lt;br/&gt; preferred terms based on frequency)</span></span>
+<span id="cb33-289"><a href="#cb33-289"></a></span>
+<span id="cb33-290"><a href="#cb33-290"></a><span class="in">```{r variant7, test = list(result_v7 = "result")}</span></span>
+<span id="cb33-291"><a href="#cb33-291"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-292"><a href="#cb33-292"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-293"><a href="#cb33-293"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-294"><a href="#cb33-294"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-295"><a href="#cb33-295"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-296"><a href="#cb33-296"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-297"><a href="#cb33-297"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-298"><a href="#cb33-298"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-299"><a href="#cb33-299"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-300"><a href="#cb33-300"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-301"><a href="#cb33-301"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-302"><a href="#cb33-302"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-303"><a href="#cb33-303"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-304"><a href="#cb33-304"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-305"><a href="#cb33-305"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-306"><a href="#cb33-306"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-307"><a href="#cb33-307"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-308"><a href="#cb33-308"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-309"><a href="#cb33-309"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-310"><a href="#cb33-310"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-311"><a href="#cb33-311"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-312"><a href="#cb33-312"></a></span>
+<span id="cb33-313"><a href="#cb33-313"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-314"><a href="#cb33-314"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-315"><a href="#cb33-315"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-316"><a href="#cb33-316"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-317"><a href="#cb33-317"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-318"><a href="#cb33-318"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-319"><a href="#cb33-319"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-320"><a href="#cb33-320"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-321"><a href="#cb33-321"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-322"><a href="#cb33-322"></a>  )</span>
+<span id="cb33-323"><a href="#cb33-323"></a></span>
+<span id="cb33-324"><a href="#cb33-324"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-325"><a href="#cb33-325"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-326"><a href="#cb33-326"></a></span>
+<span id="cb33-327"><a href="#cb33-327"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb33-328"><a href="#cb33-328"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb33-329"><a href="#cb33-329"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb33-330"><a href="#cb33-330"></a>)</span>
+<span id="cb33-331"><a href="#cb33-331"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-332"><a href="#cb33-332"></a></span>
+<span id="cb33-333"><a href="#cb33-333"></a>result</span>
+<span id="cb33-334"><a href="#cb33-334"></a><span class="in">```</span></span>
+<span id="cb33-335"><a href="#cb33-335"></a></span>
+<span id="cb33-336"><a href="#cb33-336"></a><span class="fu">## Table of AEs with an Incidence Rate $\geq$ 5% in &lt;br/&gt; Any Treatment Group (subsetting preferred terms &lt;br/&gt; based on frequency with high-level terms)</span></span>
+<span id="cb33-337"><a href="#cb33-337"></a></span>
+<span id="cb33-338"><a href="#cb33-338"></a><span class="in">```{r variant8, test = list(result_v8 = "result")}</span></span>
+<span id="cb33-339"><a href="#cb33-339"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-340"><a href="#cb33-340"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-341"><a href="#cb33-341"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-342"><a href="#cb33-342"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-343"><a href="#cb33-343"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-344"><a href="#cb33-344"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb33-345"><a href="#cb33-345"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-346"><a href="#cb33-346"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-347"><a href="#cb33-347"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-348"><a href="#cb33-348"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-349"><a href="#cb33-349"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-350"><a href="#cb33-350"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-351"><a href="#cb33-351"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-352"><a href="#cb33-352"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-353"><a href="#cb33-353"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-354"><a href="#cb33-354"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-355"><a href="#cb33-355"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb33-356"><a href="#cb33-356"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-357"><a href="#cb33-357"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb33-358"><a href="#cb33-358"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-359"><a href="#cb33-359"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-360"><a href="#cb33-360"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb33-361"><a href="#cb33-361"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-362"><a href="#cb33-362"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-363"><a href="#cb33-363"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-364"><a href="#cb33-364"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-365"><a href="#cb33-365"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-366"><a href="#cb33-366"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-367"><a href="#cb33-367"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-368"><a href="#cb33-368"></a>  <span class="fu">append_varlabels</span>(adae, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb33-369"><a href="#cb33-369"></a></span>
+<span id="cb33-370"><a href="#cb33-370"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-371"><a href="#cb33-371"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-372"><a href="#cb33-372"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-373"><a href="#cb33-373"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-374"><a href="#cb33-374"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb33-375"><a href="#cb33-375"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb33-376"><a href="#cb33-376"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-377"><a href="#cb33-377"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-378"><a href="#cb33-378"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb33-379"><a href="#cb33-379"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb33-380"><a href="#cb33-380"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb33-381"><a href="#cb33-381"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-382"><a href="#cb33-382"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-383"><a href="#cb33-383"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-384"><a href="#cb33-384"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb33-385"><a href="#cb33-385"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb33-386"><a href="#cb33-386"></a>  )</span>
+<span id="cb33-387"><a href="#cb33-387"></a></span>
+<span id="cb33-388"><a href="#cb33-388"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-389"><a href="#cb33-389"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-390"><a href="#cb33-390"></a></span>
+<span id="cb33-391"><a href="#cb33-391"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb33-392"><a href="#cb33-392"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb33-393"><a href="#cb33-393"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb33-394"><a href="#cb33-394"></a>)</span>
+<span id="cb33-395"><a href="#cb33-395"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-396"><a href="#cb33-396"></a></span>
+<span id="cb33-397"><a href="#cb33-397"></a>result</span>
+<span id="cb33-398"><a href="#cb33-398"></a><span class="in">```</span></span>
+<span id="cb33-399"><a href="#cb33-399"></a></span>
+<span id="cb33-400"><a href="#cb33-400"></a><span class="fu">## Table of AEs with an Incidence Rate $\geq$ 10% &lt;br/&gt; in Any Treatment Group (subsetting &lt;br/&gt; preferred terms based on frequency)</span></span>
+<span id="cb33-401"><a href="#cb33-401"></a></span>
+<span id="cb33-402"><a href="#cb33-402"></a><span class="in">```{r variant9, test = list(result_v9 = "result")}</span></span>
+<span id="cb33-403"><a href="#cb33-403"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-404"><a href="#cb33-404"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-405"><a href="#cb33-405"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-406"><a href="#cb33-406"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-407"><a href="#cb33-407"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-408"><a href="#cb33-408"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-409"><a href="#cb33-409"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-410"><a href="#cb33-410"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-411"><a href="#cb33-411"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-412"><a href="#cb33-412"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-413"><a href="#cb33-413"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-414"><a href="#cb33-414"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-415"><a href="#cb33-415"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-416"><a href="#cb33-416"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-417"><a href="#cb33-417"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-418"><a href="#cb33-418"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-419"><a href="#cb33-419"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-420"><a href="#cb33-420"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-421"><a href="#cb33-421"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-422"><a href="#cb33-422"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-423"><a href="#cb33-423"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-424"><a href="#cb33-424"></a></span>
+<span id="cb33-425"><a href="#cb33-425"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-426"><a href="#cb33-426"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-427"><a href="#cb33-427"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-428"><a href="#cb33-428"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-429"><a href="#cb33-429"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-430"><a href="#cb33-430"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-431"><a href="#cb33-431"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-432"><a href="#cb33-432"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-433"><a href="#cb33-433"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-434"><a href="#cb33-434"></a>  )</span>
+<span id="cb33-435"><a href="#cb33-435"></a></span>
+<span id="cb33-436"><a href="#cb33-436"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-437"><a href="#cb33-437"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-438"><a href="#cb33-438"></a></span>
+<span id="cb33-439"><a href="#cb33-439"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb33-440"><a href="#cb33-440"></a>  <span class="at">atleast =</span> <span class="fl">0.10</span>,</span>
+<span id="cb33-441"><a href="#cb33-441"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb33-442"><a href="#cb33-442"></a>)</span>
+<span id="cb33-443"><a href="#cb33-443"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-444"><a href="#cb33-444"></a></span>
+<span id="cb33-445"><a href="#cb33-445"></a>result</span>
+<span id="cb33-446"><a href="#cb33-446"></a><span class="in">```</span></span>
+<span id="cb33-447"><a href="#cb33-447"></a></span>
+<span id="cb33-448"><a href="#cb33-448"></a><span class="fu">## Table of AEs with an Incidence Rate $\geq$ 3 &lt;br/&gt; Patients in Any Treatment Group (subsetting &lt;br/&gt; preferred terms based on number of patients)</span></span>
+<span id="cb33-449"><a href="#cb33-449"></a></span>
+<span id="cb33-450"><a href="#cb33-450"></a><span class="in">```{r variant10, test = list(result_v10 = "result")}</span></span>
+<span id="cb33-451"><a href="#cb33-451"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-452"><a href="#cb33-452"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-453"><a href="#cb33-453"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-454"><a href="#cb33-454"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-455"><a href="#cb33-455"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-456"><a href="#cb33-456"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-457"><a href="#cb33-457"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-458"><a href="#cb33-458"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-459"><a href="#cb33-459"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS),</span>
+<span id="cb33-460"><a href="#cb33-460"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb33-461"><a href="#cb33-461"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-462"><a href="#cb33-462"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-463"><a href="#cb33-463"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-464"><a href="#cb33-464"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-465"><a href="#cb33-465"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-466"><a href="#cb33-466"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-467"><a href="#cb33-467"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-468"><a href="#cb33-468"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-469"><a href="#cb33-469"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-470"><a href="#cb33-470"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-471"><a href="#cb33-471"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-472"><a href="#cb33-472"></a></span>
+<span id="cb33-473"><a href="#cb33-473"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-474"><a href="#cb33-474"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-475"><a href="#cb33-475"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-476"><a href="#cb33-476"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-477"><a href="#cb33-477"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-478"><a href="#cb33-478"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-479"><a href="#cb33-479"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-480"><a href="#cb33-480"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-481"><a href="#cb33-481"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-482"><a href="#cb33-482"></a>  )</span>
+<span id="cb33-483"><a href="#cb33-483"></a></span>
+<span id="cb33-484"><a href="#cb33-484"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-485"><a href="#cb33-485"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-486"><a href="#cb33-486"></a></span>
+<span id="cb33-487"><a href="#cb33-487"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_count_in_any_col</span>(</span>
+<span id="cb33-488"><a href="#cb33-488"></a>  <span class="at">atleast =</span> <span class="dv">3</span>,</span>
+<span id="cb33-489"><a href="#cb33-489"></a>  <span class="at">col_names =</span> <span class="fu">names</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb33-490"><a href="#cb33-490"></a>)</span>
+<span id="cb33-491"><a href="#cb33-491"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-492"><a href="#cb33-492"></a></span>
+<span id="cb33-493"><a href="#cb33-493"></a>result</span>
+<span id="cb33-494"><a href="#cb33-494"></a><span class="in">```</span></span>
+<span id="cb33-495"><a href="#cb33-495"></a></span>
+<span id="cb33-496"><a href="#cb33-496"></a><span class="fu">## Table of AEs with a Difference in Incidence Rate $\geq$ 5% &lt;br/&gt; Between Any Treatment (subsetting preferred terms based &lt;br/&gt; on difference in percentage between treatment groups)</span></span>
+<span id="cb33-497"><a href="#cb33-497"></a></span>
+<span id="cb33-498"><a href="#cb33-498"></a><span class="in">```{r variant11, test = list(result_v11 = "result")}</span></span>
+<span id="cb33-499"><a href="#cb33-499"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-500"><a href="#cb33-500"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-501"><a href="#cb33-501"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-502"><a href="#cb33-502"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-503"><a href="#cb33-503"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-504"><a href="#cb33-504"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-505"><a href="#cb33-505"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-506"><a href="#cb33-506"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-507"><a href="#cb33-507"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-508"><a href="#cb33-508"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-509"><a href="#cb33-509"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-510"><a href="#cb33-510"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-511"><a href="#cb33-511"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-512"><a href="#cb33-512"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-513"><a href="#cb33-513"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-514"><a href="#cb33-514"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-515"><a href="#cb33-515"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-516"><a href="#cb33-516"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-517"><a href="#cb33-517"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-518"><a href="#cb33-518"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-519"><a href="#cb33-519"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-520"><a href="#cb33-520"></a></span>
+<span id="cb33-521"><a href="#cb33-521"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-522"><a href="#cb33-522"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-523"><a href="#cb33-523"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-524"><a href="#cb33-524"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-525"><a href="#cb33-525"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-526"><a href="#cb33-526"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-527"><a href="#cb33-527"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-528"><a href="#cb33-528"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-529"><a href="#cb33-529"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-530"><a href="#cb33-530"></a>  )</span>
+<span id="cb33-531"><a href="#cb33-531"></a></span>
+<span id="cb33-532"><a href="#cb33-532"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-533"><a href="#cb33-533"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-534"><a href="#cb33-534"></a></span>
+<span id="cb33-535"><a href="#cb33-535"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(</span>
+<span id="cb33-536"><a href="#cb33-536"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb33-537"><a href="#cb33-537"></a>  <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM)</span>
+<span id="cb33-538"><a href="#cb33-538"></a>)</span>
+<span id="cb33-539"><a href="#cb33-539"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-540"><a href="#cb33-540"></a></span>
+<span id="cb33-541"><a href="#cb33-541"></a>result</span>
+<span id="cb33-542"><a href="#cb33-542"></a><span class="in">```</span></span>
+<span id="cb33-543"><a href="#cb33-543"></a></span>
+<span id="cb33-544"><a href="#cb33-544"></a><span class="fu">## Table of AEs with an Incidence Rate $\geq$ 5% &lt;br/&gt; in B: Placebo (subsetting preferred terms based &lt;br/&gt; on frequency for a particular treatment group)</span></span>
+<span id="cb33-545"><a href="#cb33-545"></a></span>
+<span id="cb33-546"><a href="#cb33-546"></a><span class="in">```{r variant12, test = list(result_v12 = "result")}</span></span>
+<span id="cb33-547"><a href="#cb33-547"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-548"><a href="#cb33-548"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-549"><a href="#cb33-549"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-550"><a href="#cb33-550"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-551"><a href="#cb33-551"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-552"><a href="#cb33-552"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-553"><a href="#cb33-553"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-554"><a href="#cb33-554"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-555"><a href="#cb33-555"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-556"><a href="#cb33-556"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-557"><a href="#cb33-557"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-558"><a href="#cb33-558"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-559"><a href="#cb33-559"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-560"><a href="#cb33-560"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-561"><a href="#cb33-561"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-562"><a href="#cb33-562"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-563"><a href="#cb33-563"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-564"><a href="#cb33-564"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-565"><a href="#cb33-565"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-566"><a href="#cb33-566"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-567"><a href="#cb33-567"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-568"><a href="#cb33-568"></a></span>
+<span id="cb33-569"><a href="#cb33-569"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-570"><a href="#cb33-570"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-571"><a href="#cb33-571"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-572"><a href="#cb33-572"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-573"><a href="#cb33-573"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-574"><a href="#cb33-574"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-575"><a href="#cb33-575"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-576"><a href="#cb33-576"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-577"><a href="#cb33-577"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-578"><a href="#cb33-578"></a>  )</span>
+<span id="cb33-579"><a href="#cb33-579"></a></span>
+<span id="cb33-580"><a href="#cb33-580"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-581"><a href="#cb33-581"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-582"><a href="#cb33-582"></a></span>
+<span id="cb33-583"><a href="#cb33-583"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_cols</span>(</span>
+<span id="cb33-584"><a href="#cb33-584"></a>  <span class="at">atleast =</span> <span class="fl">0.05</span>,</span>
+<span id="cb33-585"><a href="#cb33-585"></a>  <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>)</span>
+<span id="cb33-586"><a href="#cb33-586"></a>)</span>
+<span id="cb33-587"><a href="#cb33-587"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-588"><a href="#cb33-588"></a></span>
+<span id="cb33-589"><a href="#cb33-589"></a>result</span>
+<span id="cb33-590"><a href="#cb33-590"></a><span class="in">```</span></span>
+<span id="cb33-591"><a href="#cb33-591"></a></span>
+<span id="cb33-592"><a href="#cb33-592"></a><span class="fu">## Table of AEs with a Difference in Incidence Rate $\geq$ 5% Between &lt;br/&gt; Arm A and Arm B or Arm C (displaying preferred terms with a &lt;br/&gt; difference of at least x% between selected treatment groups)</span></span>
+<span id="cb33-593"><a href="#cb33-593"></a></span>
+<span id="cb33-594"><a href="#cb33-594"></a><span class="in">```{r variant13, test = list(result_v13 = "result")}</span></span>
+<span id="cb33-595"><a href="#cb33-595"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-596"><a href="#cb33-596"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb33-597"><a href="#cb33-597"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb33-598"><a href="#cb33-598"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb33-599"><a href="#cb33-599"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb33-600"><a href="#cb33-600"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb33-601"><a href="#cb33-601"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb33-602"><a href="#cb33-602"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb33-603"><a href="#cb33-603"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb33-604"><a href="#cb33-604"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb33-605"><a href="#cb33-605"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-606"><a href="#cb33-606"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb33-607"><a href="#cb33-607"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb33-608"><a href="#cb33-608"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb33-609"><a href="#cb33-609"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb33-610"><a href="#cb33-610"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-611"><a href="#cb33-611"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb33-612"><a href="#cb33-612"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb33-613"><a href="#cb33-613"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb33-614"><a href="#cb33-614"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-615"><a href="#cb33-615"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb33-616"><a href="#cb33-616"></a></span>
+<span id="cb33-617"><a href="#cb33-617"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb33-618"><a href="#cb33-618"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb33-619"><a href="#cb33-619"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-620"><a href="#cb33-620"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb33-621"><a href="#cb33-621"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb33-622"><a href="#cb33-622"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb33-623"><a href="#cb33-623"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb33-624"><a href="#cb33-624"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb33-625"><a href="#cb33-625"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb33-626"><a href="#cb33-626"></a>  )</span>
+<span id="cb33-627"><a href="#cb33-627"></a></span>
+<span id="cb33-628"><a href="#cb33-628"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb33-629"><a href="#cb33-629"></a>result <span class="ot">&lt;-</span> <span class="fu">trim_rows</span>(result, <span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb33-630"><a href="#cb33-630"></a></span>
+<span id="cb33-631"><a href="#cb33-631"></a>row_condition1 <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>))</span>
+<span id="cb33-632"><a href="#cb33-632"></a>row_condition2 <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="at">col_names =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))</span>
+<span id="cb33-633"><a href="#cb33-633"></a>row_condition <span class="ot">&lt;-</span> row_condition1 <span class="sc">|</span> row_condition2</span>
+<span id="cb33-634"><a href="#cb33-634"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(row_condition))</span>
+<span id="cb33-635"><a href="#cb33-635"></a></span>
+<span id="cb33-636"><a href="#cb33-636"></a>result</span>
+<span id="cb33-637"><a href="#cb33-637"></a><span class="in">```</span></span>
+<span id="cb33-638"><a href="#cb33-638"></a></span>
+<span id="cb33-639"><a href="#cb33-639"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb33-640"><a href="#cb33-640"></a></span>
+<span id="cb33-641"><a href="#cb33-641"></a><span class="fu">## `teal` App</span></span>
+<span id="cb33-642"><a href="#cb33-642"></a></span>
+<span id="cb33-643"><a href="#cb33-643"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb33-644"><a href="#cb33-644"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb33-645"><a href="#cb33-645"></a></span>
+<span id="cb33-646"><a href="#cb33-646"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb33-647"><a href="#cb33-647"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb33-648"><a href="#cb33-648"></a><span class="fu">library</span>(scda)</span>
+<span id="cb33-649"><a href="#cb33-649"></a></span>
+<span id="cb33-650"><a href="#cb33-650"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb33-651"><a href="#cb33-651"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb33-652"><a href="#cb33-652"></a></span>
+<span id="cb33-653"><a href="#cb33-653"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb33-654"><a href="#cb33-654"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb33-655"><a href="#cb33-655"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb33-656"><a href="#cb33-656"></a></span>
+<span id="cb33-657"><a href="#cb33-657"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb33-658"><a href="#cb33-658"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb33-659"><a href="#cb33-659"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb33-660"><a href="#cb33-660"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb33-661"><a href="#cb33-661"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb33-662"><a href="#cb33-662"></a>  ),</span>
+<span id="cb33-663"><a href="#cb33-663"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb33-664"><a href="#cb33-664"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb33-665"><a href="#cb33-665"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb33-666"><a href="#cb33-666"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb33-667"><a href="#cb33-667"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb33-668"><a href="#cb33-668"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb33-669"><a href="#cb33-669"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb33-670"><a href="#cb33-670"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb33-671"><a href="#cb33-671"></a>      ),</span>
+<span id="cb33-672"><a href="#cb33-672"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb33-673"><a href="#cb33-673"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb33-674"><a href="#cb33-674"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb33-675"><a href="#cb33-675"></a>      ),</span>
+<span id="cb33-676"><a href="#cb33-676"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb33-677"><a href="#cb33-677"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb33-678"><a href="#cb33-678"></a>    )</span>
+<span id="cb33-679"><a href="#cb33-679"></a>  )</span>
+<span id="cb33-680"><a href="#cb33-680"></a>)</span>
+<span id="cb33-681"><a href="#cb33-681"></a></span>
+<span id="cb33-682"><a href="#cb33-682"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb33-683"><a href="#cb33-683"></a><span class="in">```</span></span>
+<span id="cb33-684"><a href="#cb33-684"></a></span>
+<span id="cb33-685"><a href="#cb33-685"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb33-686"><a href="#cb33-686"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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--- /dev/null
+++ b/stable/tables/adverse-events/aet02_smq.html
@@ -0,0 +1,2442 @@
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+<style>
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+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
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+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
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+/* CSS for syntax highlighting */
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
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+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+
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+ <span class="menu-text">ADA</span></a>
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+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
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+ <span class="menu-text">Deaths</span></a>
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+</li>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET02_SMQ</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events by Standardized MedDRA Query</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Customized Queries</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet02_smq_cache/html/setup_fbf09964ce26fb12598f02bebc023f96">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb1-36"><a href="#cb1-36"></a></span>
+<span id="cb1-37"><a href="#cb1-37"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(<span class="at">df =</span> adae, <span class="at">aag_summary =</span> aag_summary, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>))</span>
+<span id="cb1-39"><a href="#cb1-39"></a></span>
+<span id="cb1-40"><a href="#cb1-40"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb1-43"><a href="#cb1-43"></a></span>
+<span id="cb1-44"><a href="#cb1-44"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet02_smq_cache/html/variant1_e6fdcefc2246d964c0299e792ce37c3c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>    )</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>    )</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-34"><a href="#cb2-34"></a></span>
+<span id="cb2-35"><a href="#cb2-35"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  lyt,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-39"><a href="#cb2-39"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-43"><a href="#cb2-43"></a></span>
+<span id="cb2-44"><a href="#cb2-44"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                      ARM A        ARM B        ARM C   
+  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     72 (53.7%)   79 (59.0%)   75 (56.8%)
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  
+  Total number of patients with at least one adverse event   72 (53.7%)   79 (59.0%)   75 (56.8%)
+  Total number of events                                        119          139          141    
+  dcd B.2.2.3.1                                              48 (35.8%)   54 (40.3%)   51 (38.6%)
+  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet02_smq_cache/html/variant2_7f90c6dc05bbc0b06443adf68247e1a6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb4-3"><a href="#cb4-3"></a>}</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>    )</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>    ),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-36"><a href="#cb4-36"></a></span>
+<span id="cb4-37"><a href="#cb4-37"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb4-40"><a href="#cb4-40"></a>}</span>
+<span id="cb4-41"><a href="#cb4-41"></a></span>
+<span id="cb4-42"><a href="#cb4-42"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-43"><a href="#cb4-43"></a>  lyt,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-46"><a href="#cb4-46"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-49"><a href="#cb4-49"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-50"><a href="#cb4-50"></a></span>
+<span id="cb4-51"><a href="#cb4-51"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                      ARM A         ARM B         ARM C   
+  Dictionary-Derived Term                                     (N=134)       (N=134)       (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     95 (70.9%)   103 (76.9%)   108 (81.8%)
+D.2.1.5.3/A.1.1.1.1 AESI                                                                           
+  Total number of patients with at least one adverse event   74 (55.2%)   80 (59.7%)    87 (65.9%) 
+  Total number of events                                        126           134           162    
+  dcd D.2.1.5.3                                              47 (35.1%)   58 (43.3%)    57 (43.2%) 
+  dcd A.1.1.1.1                                              50 (37.3%)   45 (33.6%)    63 (47.7%) 
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                    
+  Total number of patients with at least one adverse event   72 (53.7%)   79 (59.0%)    75 (56.8%) 
+  Total number of events                                        119           139           141    
+  dcd B.2.2.3.1                                              48 (35.8%)   54 (40.3%)    51 (38.6%) 
+  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)    43 (32.6%) 
+non observed SMQ02NAM level(BROAD)                                                                 
+  Total number of patients with at least one adverse event       0             0             0     
+  Total number of events                                         0             0             0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aet02_smq_cache/html/teal_3fd0be2299944d993d79b7f48945d9ed">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-9"><a href="#cb6-9"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a></span>
+<span id="cb6-11"><a href="#cb6-11"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb6-14"><a href="#cb6-14"></a>)</span>
+<span id="cb6-15"><a href="#cb6-15"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>)</span>
+<span id="cb6-20"><a href="#cb6-20"></a></span>
+<span id="cb6-21"><a href="#cb6-21"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>    ),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>    ),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  ),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">label =</span> <span class="st">"Adverse events by `SMQ` Table"</span>,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>      ),</span>
+<span id="cb6-39"><a href="#cb6-39"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-40"><a href="#cb6-40"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb6-42"><a href="#cb6-42"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-43"><a href="#cb6-43"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb6-44"><a href="#cb6-44"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>      )</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    )</span>
+<span id="cb6-47"><a href="#cb6-47"></a>  )</span>
+<span id="cb6-48"><a href="#cb6-48"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:19:16.0808 pid:10900 token:[] teal.modules.clinical Initializing tm_t_smq</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet02_smq_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet02_smq_cache/html/sessioninfo_5167356f98fc5bccc201f940f42a79e4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] stringr_1.5.0                scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          
+[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         
+[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      
+[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           
+[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[85] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet02_smq_cache/html/snapshot_a6804d01b5009965f9d26c7164c3e30b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet02_smq.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+  anchorJS.options = {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET02_SMQ</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events by Standardized MedDRA Query</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb12-20"><a href="#cb12-20"></a></span>
+<span id="cb12-21"><a href="#cb12-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-23"><a href="#cb12-23"></a></span>
+<span id="cb12-24"><a href="#cb12-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-25"><a href="#cb12-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-26"><a href="#cb12-26"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-27"><a href="#cb12-27"></a></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb12-32"><a href="#cb12-32"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb12-33"><a href="#cb12-33"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb12-34"><a href="#cb12-34"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb12-35"><a href="#cb12-35"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb12-37"><a href="#cb12-37"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>)</span>
+<span id="cb12-39"><a href="#cb12-39"></a></span>
+<span id="cb12-40"><a href="#cb12-40"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb12-42"><a href="#cb12-42"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb12-43"><a href="#cb12-43"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb12-48"><a href="#cb12-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb12-50"><a href="#cb12-50"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb12-51"><a href="#cb12-51"></a></span>
+<span id="cb12-52"><a href="#cb12-52"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(<span class="at">df =</span> adae, <span class="at">aag_summary =</span> aag_summary, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>))</span>
+<span id="cb12-54"><a href="#cb12-54"></a></span>
+<span id="cb12-55"><a href="#cb12-55"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-63"><a href="#cb12-63"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb12-64"><a href="#cb12-64"></a>  )</span>
+<span id="cb12-65"><a href="#cb12-65"></a><span class="in">```</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a></span>
+<span id="cb12-67"><a href="#cb12-67"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a></span>
+<span id="cb12-69"><a href="#cb12-69"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb12-71"><a href="#cb12-71"></a></span>
+<span id="cb12-72"><a href="#cb12-72"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-74"><a href="#cb12-74"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-75"><a href="#cb12-75"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-76"><a href="#cb12-76"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb12-77"><a href="#cb12-77"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-78"><a href="#cb12-78"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb12-79"><a href="#cb12-79"></a>    )</span>
+<span id="cb12-80"><a href="#cb12-80"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-81"><a href="#cb12-81"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-82"><a href="#cb12-82"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb12-83"><a href="#cb12-83"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-84"><a href="#cb12-84"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-85"><a href="#cb12-85"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-86"><a href="#cb12-86"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-87"><a href="#cb12-87"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb12-88"><a href="#cb12-88"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-90"><a href="#cb12-90"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-91"><a href="#cb12-91"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-92"><a href="#cb12-92"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-93"><a href="#cb12-93"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb12-94"><a href="#cb12-94"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb12-95"><a href="#cb12-95"></a>    )</span>
+<span id="cb12-96"><a href="#cb12-96"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-97"><a href="#cb12-97"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-98"><a href="#cb12-98"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-99"><a href="#cb12-99"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L,</span>
+<span id="cb12-100"><a href="#cb12-100"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-101"><a href="#cb12-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-102"><a href="#cb12-102"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-103"><a href="#cb12-103"></a></span>
+<span id="cb12-104"><a href="#cb12-104"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-105"><a href="#cb12-105"></a>  lyt,</span>
+<span id="cb12-106"><a href="#cb12-106"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb12-107"><a href="#cb12-107"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-108"><a href="#cb12-108"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-109"><a href="#cb12-109"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb12-110"><a href="#cb12-110"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-111"><a href="#cb12-111"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb12-112"><a href="#cb12-112"></a></span>
+<span id="cb12-113"><a href="#cb12-113"></a>result</span>
+<span id="cb12-114"><a href="#cb12-114"></a><span class="in">```</span></span>
+<span id="cb12-115"><a href="#cb12-115"></a></span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="fu">## Table with Customized Queries</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a></span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-119"><a href="#cb12-119"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb12-120"><a href="#cb12-120"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb12-121"><a href="#cb12-121"></a>}</span>
+<span id="cb12-122"><a href="#cb12-122"></a></span>
+<span id="cb12-123"><a href="#cb12-123"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-124"><a href="#cb12-124"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-125"><a href="#cb12-125"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-126"><a href="#cb12-126"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-127"><a href="#cb12-127"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb12-128"><a href="#cb12-128"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-129"><a href="#cb12-129"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb12-130"><a href="#cb12-130"></a>    )</span>
+<span id="cb12-131"><a href="#cb12-131"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-132"><a href="#cb12-132"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-133"><a href="#cb12-133"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb12-134"><a href="#cb12-134"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-135"><a href="#cb12-135"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-136"><a href="#cb12-136"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-137"><a href="#cb12-137"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-138"><a href="#cb12-138"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb12-139"><a href="#cb12-139"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-140"><a href="#cb12-140"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-141"><a href="#cb12-141"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-142"><a href="#cb12-142"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-143"><a href="#cb12-143"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-144"><a href="#cb12-144"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb12-145"><a href="#cb12-145"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb12-146"><a href="#cb12-146"></a>    ),</span>
+<span id="cb12-147"><a href="#cb12-147"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb12-148"><a href="#cb12-148"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-149"><a href="#cb12-149"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-150"><a href="#cb12-150"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-151"><a href="#cb12-151"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-152"><a href="#cb12-152"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-154"><a href="#cb12-154"></a></span>
+<span id="cb12-155"><a href="#cb12-155"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb12-156"><a href="#cb12-156"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb12-157"><a href="#cb12-157"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb12-158"><a href="#cb12-158"></a>}</span>
+<span id="cb12-159"><a href="#cb12-159"></a></span>
+<span id="cb12-160"><a href="#cb12-160"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-161"><a href="#cb12-161"></a>  lyt,</span>
+<span id="cb12-162"><a href="#cb12-162"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb12-163"><a href="#cb12-163"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-164"><a href="#cb12-164"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-165"><a href="#cb12-165"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb12-166"><a href="#cb12-166"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-167"><a href="#cb12-167"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb12-168"><a href="#cb12-168"></a></span>
+<span id="cb12-169"><a href="#cb12-169"></a>result</span>
+<span id="cb12-170"><a href="#cb12-170"></a><span class="in">```</span></span>
+<span id="cb12-171"><a href="#cb12-171"></a></span>
+<span id="cb12-172"><a href="#cb12-172"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-173"><a href="#cb12-173"></a></span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a></span>
+<span id="cb12-176"><a href="#cb12-176"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb12-178"><a href="#cb12-178"></a></span>
+<span id="cb12-179"><a href="#cb12-179"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-180"><a href="#cb12-180"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-181"><a href="#cb12-181"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-182"><a href="#cb12-182"></a></span>
+<span id="cb12-183"><a href="#cb12-183"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-184"><a href="#cb12-184"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-185"><a href="#cb12-185"></a></span>
+<span id="cb12-186"><a href="#cb12-186"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-187"><a href="#cb12-187"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-188"><a href="#cb12-188"></a></span>
+<span id="cb12-189"><a href="#cb12-189"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-190"><a href="#cb12-190"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb12-191"><a href="#cb12-191"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb12-192"><a href="#cb12-192"></a>)</span>
+<span id="cb12-193"><a href="#cb12-193"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-194"><a href="#cb12-194"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb12-195"><a href="#cb12-195"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb12-196"><a href="#cb12-196"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-197"><a href="#cb12-197"></a>)</span>
+<span id="cb12-198"><a href="#cb12-198"></a></span>
+<span id="cb12-199"><a href="#cb12-199"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-200"><a href="#cb12-200"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-201"><a href="#cb12-201"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb12-202"><a href="#cb12-202"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb12-203"><a href="#cb12-203"></a>    ),</span>
+<span id="cb12-204"><a href="#cb12-204"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb12-205"><a href="#cb12-205"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span></span>
+<span id="cb12-206"><a href="#cb12-206"></a>    ),</span>
+<span id="cb12-207"><a href="#cb12-207"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-208"><a href="#cb12-208"></a>  ),</span>
+<span id="cb12-209"><a href="#cb12-209"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-210"><a href="#cb12-210"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb12-211"><a href="#cb12-211"></a>      <span class="at">label =</span> <span class="st">"Adverse events by `SMQ` Table"</span>,</span>
+<span id="cb12-212"><a href="#cb12-212"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-213"><a href="#cb12-213"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-214"><a href="#cb12-214"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb12-215"><a href="#cb12-215"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-216"><a href="#cb12-216"></a>      ),</span>
+<span id="cb12-217"><a href="#cb12-217"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-218"><a href="#cb12-218"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb12-219"><a href="#cb12-219"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb12-220"><a href="#cb12-220"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-221"><a href="#cb12-221"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb12-222"><a href="#cb12-222"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb12-223"><a href="#cb12-223"></a>      )</span>
+<span id="cb12-224"><a href="#cb12-224"></a>    )</span>
+<span id="cb12-225"><a href="#cb12-225"></a>  )</span>
+<span id="cb12-226"><a href="#cb12-226"></a>)</span>
+<span id="cb12-227"><a href="#cb12-227"></a></span>
+<span id="cb12-228"><a href="#cb12-228"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-229"><a href="#cb12-229"></a><span class="in">```</span></span>
+<span id="cb12-230"><a href="#cb12-230"></a></span>
+<span id="cb12-231"><a href="#cb12-231"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-232"><a href="#cb12-232"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
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+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
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+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<div class="quarto-title-block"><div><h1 class="title">AET03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events by Greatest Intensity</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
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+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet03_cache/html/setup_fa6794b422392d0c0ebebfe6cca41a7a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p>For illustrative purposes, we will create a new factor variable in ADAE, <code>ASEV</code>, with all intensity levels including <code>"LIFE THREATENING"</code>.</p>
+<div class="cell" data-hash="aet03_cache/html/pre-processing_027c1380708c5bed74f9f2c9e126462f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">ASEV =</span> <span class="fu">as.character</span>(AESEV))</span>
+<span id="cb2-2"><a href="#cb2-2"></a>adae<span class="sc">$</span>ASEV[<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>] <span class="ot">&lt;-</span> <span class="st">"LIFE THREATENING"</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">ASEV =</span> <span class="fu">factor</span>(ASEV, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"MILD"</span>, <span class="st">"MODERATE"</span>, <span class="st">"SEVERE"</span>, <span class="st">"LIFE THREATENING"</span>)))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet03_cache/html/variant1_3a869a9027eac6569b27da78e1aae2da">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="st">"- Any Intensity -"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"MILD"</span>, <span class="st">"MODERATE"</span>, <span class="st">"SEVERE"</span>, <span class="st">"LIFE THREATENING"</span>))</span>
+<span id="cb3-2"><a href="#cb3-2"></a></span>
+<span id="cb3-3"><a href="#cb3-3"></a>split_fun <span class="ot">&lt;-</span> trim_levels_in_group</span>
+<span id="cb3-4"><a href="#cb3-4"></a></span>
+<span id="cb3-5"><a href="#cb3-5"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb3-8"><a href="#cb3-8"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb3-9"><a href="#cb3-9"></a>    <span class="at">grade_groups =</span> grade_groups</span>
+<span id="cb3-10"><a href="#cb3-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-11"><a href="#cb3-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb3-12"><a href="#cb3-12"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb3-13"><a href="#cb3-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb3-14"><a href="#cb3-14"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">split_fun =</span> <span class="fu">split_fun</span>(<span class="st">"ASEV"</span>),</span>
+<span id="cb3-16"><a href="#cb3-16"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb3-17"><a href="#cb3-17"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb3-18"><a href="#cb3-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-19"><a href="#cb3-19"></a>  <span class="fu">summarize_occurrences_by_grade</span>(</span>
+<span id="cb3-20"><a href="#cb3-20"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb3-21"><a href="#cb3-21"></a>    <span class="at">grade_groups =</span> grade_groups</span>
+<span id="cb3-22"><a href="#cb3-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-23"><a href="#cb3-23"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb3-24"><a href="#cb3-24"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb3-25"><a href="#cb3-25"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb3-26"><a href="#cb3-26"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb3-27"><a href="#cb3-27"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb3-28"><a href="#cb3-28"></a>    <span class="at">split_fun =</span> <span class="fu">split_fun</span>(<span class="st">"ASEV"</span>),</span>
+<span id="cb3-29"><a href="#cb3-29"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb3-30"><a href="#cb3-30"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEDECOD)</span>
+<span id="cb3-31"><a href="#cb3-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-32"><a href="#cb3-32"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb3-33"><a href="#cb3-33"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb3-34"><a href="#cb3-34"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb3-35"><a href="#cb3-35"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"- Any Intensity -"</span>)</span>
+<span id="cb3-36"><a href="#cb3-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-37"><a href="#cb3-37"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb3-38"><a href="#cb3-38"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb3-39"><a href="#cb3-39"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb3-40"><a href="#cb3-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-41"><a href="#cb3-41"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AESEV"</span>, <span class="at">indent =</span> 2L)</span>
+<span id="cb3-42"><a href="#cb3-42"></a></span>
+<span id="cb3-43"><a href="#cb3-43"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb3-44"><a href="#cb3-44"></a>  <span class="fu">build_table</span>(</span>
+<span id="cb3-45"><a href="#cb3-45"></a>    adae,</span>
+<span id="cb3-46"><a href="#cb3-46"></a>    <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb3-47"><a href="#cb3-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-48"><a href="#cb3-48"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb3-49"><a href="#cb3-49"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb3-50"><a href="#cb3-50"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb3-51"><a href="#cb3-51"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb3-52"><a href="#cb3-52"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-53"><a href="#cb3-53"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb3-54"><a href="#cb3-54"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb3-55"><a href="#cb3-55"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb3-56"><a href="#cb3-56"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb3-57"><a href="#cb3-57"></a>  )</span>
+<span id="cb3-58"><a href="#cb3-58"></a></span>
+<span id="cb3-59"><a href="#cb3-59"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                            
+  MedDRA Preferred Term      A: Drug X    B: Placebo   C: Combination
+    Severity/Intensity        (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————
+- Any Intensity -           100 (74.6%)   98 (73.1%)    103 (78.0%)  
+MILD                         5 (3.7%)      7 (5.2%)       4 (3.0%)   
+MODERATE                    17 (12.7%)    21 (15.7%)     20 (15.2%)  
+SEVERE                      77 (57.5%)    69 (51.5%)     77 (58.3%)  
+LIFE THREATENING             1 (0.7%)      1 (0.7%)       2 (1.5%)   
+cl A.1                                                               
+  - Any Intensity -         68 (50.7%)    58 (43.3%)     76 (57.6%)  
+  MILD                      27 (20.1%)    19 (14.2%)     34 (25.8%)  
+  MODERATE                  40 (29.9%)    39 (29.1%)     41 (31.1%)  
+  LIFE THREATENING           1 (0.7%)         0           1 (0.8%)   
+  dcd A.1.1.1.1                                                      
+    - Any Intensity -       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+    MILD                    45 (33.6%)    31 (23.1%)     51 (38.6%)  
+    LIFE THREATENING             0            0           1 (0.8%)   
+  dcd A.1.1.1.2                                                      
+    - Any Intensity -       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+    MODERATE                40 (29.9%)    39 (29.1%)     41 (31.1%)  
+    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   
+cl B.2                                                               
+  - Any Intensity -         62 (46.3%)    56 (41.8%)     74 (56.1%)  
+  MILD                      23 (17.2%)    22 (16.4%)     28 (21.2%)  
+  MODERATE                  38 (28.4%)    34 (25.4%)     45 (34.1%)  
+  LIFE THREATENING           1 (0.7%)         0           1 (0.8%)   
+  dcd B.2.2.3.1                                                      
+    - Any Intensity -       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+    MILD                    38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                      
+    - Any Intensity -       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+    MODERATE                38 (28.4%)    34 (25.4%)     45 (34.1%)  
+    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   
+cl D.1                                                               
+  - Any Intensity -         64 (47.8%)    54 (40.3%)     68 (51.5%)  
+  MODERATE                  21 (15.7%)    22 (16.4%)     22 (16.7%)  
+  SEVERE                    42 (31.3%)    32 (23.9%)     44 (33.3%)  
+  LIFE THREATENING           1 (0.7%)         0           2 (1.5%)   
+  dcd D.1.1.1.1                                                      
+    - Any Intensity -       42 (31.3%)    32 (23.9%)     46 (34.8%)  
+    SEVERE                  42 (31.3%)    32 (23.9%)     45 (34.1%)  
+    LIFE THREATENING             0            0           1 (0.8%)   
+  dcd D.1.1.4.2                                                      
+    - Any Intensity -       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+    MODERATE                37 (27.6%)    34 (25.4%)     39 (29.5%)  
+    LIFE THREATENING         1 (0.7%)         0           1 (0.8%)   
+cl D.2                                                               
+  - Any Intensity -         37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  MILD                      37 (27.6%)    46 (34.3%)     49 (37.1%)  
+  LIFE THREATENING               0            0           1 (0.8%)   
+  dcd D.2.1.5.3                                                      
+    - Any Intensity -       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+    MILD                    37 (27.6%)    46 (34.3%)     49 (37.1%)  
+    LIFE THREATENING             0            0           1 (0.8%)   
+cl C.2                                                               
+  - Any Intensity -         28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  MODERATE                  28 (20.9%)    36 (26.9%)     47 (35.6%)  
+  LIFE THREATENING               0            0           1 (0.8%)   
+  dcd C.2.1.2.1                                                      
+    - Any Intensity -       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+    MODERATE                28 (20.9%)    36 (26.9%)     47 (35.6%)  
+    LIFE THREATENING             0            0           1 (0.8%)   
+cl B.1                                                               
+  - Any Intensity -         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  SEVERE                    38 (28.4%)    36 (26.9%)     36 (27.3%)  
+  LIFE THREATENING               0         1 (0.7%)          0       
+  dcd B.1.1.1.1                                                      
+    - Any Intensity -       38 (28.4%)    37 (27.6%)     36 (27.3%)  
+    SEVERE                  38 (28.4%)    36 (26.9%)     36 (27.3%)  
+    LIFE THREATENING             0         1 (0.7%)          0       
+cl C.1                                                               
+  - Any Intensity -         36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  SEVERE                    36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                      
+    - Any Intensity -       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+    SEVERE                  36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aet03_cache/html/teal_0f7d6834e4008e7a51cefaf081b1c26d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb5-2"><a href="#cb5-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb5-3"><a href="#cb5-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb5-4"><a href="#cb5-4"></a></span>
+<span id="cb5-5"><a href="#cb5-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb5-6"><a href="#cb5-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb5-9"><a href="#cb5-9"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb5-12"><a href="#cb5-12"></a>    <span class="at">code =</span></span>
+<span id="cb5-13"><a href="#cb5-13"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a><span class="st">      ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb5-15"><a href="#cb5-15"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb5-16"><a href="#cb5-16"></a>  ),</span>
+<span id="cb5-17"><a href="#cb5-17"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb5-18"><a href="#cb5-18"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb5-19"><a href="#cb5-19"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb5-20"><a href="#cb5-20"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb5-21"><a href="#cb5-21"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb5-22"><a href="#cb5-22"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb5-23"><a href="#cb5-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb5-24"><a href="#cb5-24"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb5-25"><a href="#cb5-25"></a>      ),</span>
+<span id="cb5-26"><a href="#cb5-26"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb5-27"><a href="#cb5-27"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb5-28"><a href="#cb5-28"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb5-29"><a href="#cb5-29"></a>      ),</span>
+<span id="cb5-30"><a href="#cb5-30"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb5-31"><a href="#cb5-31"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb5-32"><a href="#cb5-32"></a>        <span class="at">selected =</span> <span class="st">"AESEV"</span></span>
+<span id="cb5-33"><a href="#cb5-33"></a>      )</span>
+<span id="cb5-34"><a href="#cb5-34"></a>    )</span>
+<span id="cb5-35"><a href="#cb5-35"></a>  )</span>
+<span id="cb5-36"><a href="#cb5-36"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:14:49.0451 pid:10115 token:[] teal.modules.clinical Initializing tm_t_events_by_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet03_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet03_cache/html/sessioninfo_9d26eace9b5b4ab4856ea37d11ef91f5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet03_cache/html/snapshot_dd549f40ac59934b39344e39c1592619">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> AET03</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events by Greatest Intensity</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-19"><a href="#cb11-19"></a></span>
+<span id="cb11-20"><a href="#cb11-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb11-21"><a href="#cb11-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a></span>
+<span id="cb11-23"><a href="#cb11-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb11-24"><a href="#cb11-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb11-25"><a href="#cb11-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb11-26"><a href="#cb11-26"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb11-27"><a href="#cb11-27"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb11-28"><a href="#cb11-28"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb11-29"><a href="#cb11-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb11-31"><a href="#cb11-31"></a><span class="in">```</span></span>
+<span id="cb11-32"><a href="#cb11-32"></a></span>
+<span id="cb11-33"><a href="#cb11-33"></a>For illustrative purposes, we will create a new factor variable in ADAE, <span class="in">`ASEV`</span>, with all intensity levels including <span class="in">`"LIFE THREATENING"`</span>.</span>
+<span id="cb11-34"><a href="#cb11-34"></a></span>
+<span id="cb11-35"><a href="#cb11-35"></a><span class="in">```{r pre-processing}</span></span>
+<span id="cb11-36"><a href="#cb11-36"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">ASEV =</span> <span class="fu">as.character</span>(AESEV))</span>
+<span id="cb11-37"><a href="#cb11-37"></a>adae<span class="sc">$</span>ASEV[<span class="dv">1</span><span class="sc">:</span><span class="dv">15</span>] <span class="ot">&lt;-</span> <span class="st">"LIFE THREATENING"</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">ASEV =</span> <span class="fu">factor</span>(ASEV, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"MILD"</span>, <span class="st">"MODERATE"</span>, <span class="st">"SEVERE"</span>, <span class="st">"LIFE THREATENING"</span>)))</span>
+<span id="cb11-39"><a href="#cb11-39"></a><span class="in">```</span></span>
+<span id="cb11-40"><a href="#cb11-40"></a></span>
+<span id="cb11-41"><a href="#cb11-41"></a><span class="fu">## Standard Table</span></span>
+<span id="cb11-42"><a href="#cb11-42"></a></span>
+<span id="cb11-43"><a href="#cb11-43"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-44"><a href="#cb11-44"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="st">"- Any Intensity -"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"MILD"</span>, <span class="st">"MODERATE"</span>, <span class="st">"SEVERE"</span>, <span class="st">"LIFE THREATENING"</span>))</span>
+<span id="cb11-45"><a href="#cb11-45"></a></span>
+<span id="cb11-46"><a href="#cb11-46"></a>split_fun <span class="ot">&lt;-</span> trim_levels_in_group</span>
+<span id="cb11-47"><a href="#cb11-47"></a></span>
+<span id="cb11-48"><a href="#cb11-48"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-49"><a href="#cb11-49"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-50"><a href="#cb11-50"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb11-51"><a href="#cb11-51"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb11-52"><a href="#cb11-52"></a>    <span class="at">grade_groups =</span> grade_groups</span>
+<span id="cb11-53"><a href="#cb11-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-54"><a href="#cb11-54"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-55"><a href="#cb11-55"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-56"><a href="#cb11-56"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-57"><a href="#cb11-57"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb11-58"><a href="#cb11-58"></a>    <span class="at">split_fun =</span> <span class="fu">split_fun</span>(<span class="st">"ASEV"</span>),</span>
+<span id="cb11-59"><a href="#cb11-59"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-60"><a href="#cb11-60"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb11-61"><a href="#cb11-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-62"><a href="#cb11-62"></a>  <span class="fu">summarize_occurrences_by_grade</span>(</span>
+<span id="cb11-63"><a href="#cb11-63"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb11-64"><a href="#cb11-64"></a>    <span class="at">grade_groups =</span> grade_groups</span>
+<span id="cb11-65"><a href="#cb11-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-66"><a href="#cb11-66"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-67"><a href="#cb11-67"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb11-68"><a href="#cb11-68"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-69"><a href="#cb11-69"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb11-70"><a href="#cb11-70"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb11-71"><a href="#cb11-71"></a>    <span class="at">split_fun =</span> <span class="fu">split_fun</span>(<span class="st">"ASEV"</span>),</span>
+<span id="cb11-72"><a href="#cb11-72"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-73"><a href="#cb11-73"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEDECOD)</span>
+<span id="cb11-74"><a href="#cb11-74"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-75"><a href="#cb11-75"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb11-76"><a href="#cb11-76"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb11-77"><a href="#cb11-77"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb11-78"><a href="#cb11-78"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"- Any Intensity -"</span>)</span>
+<span id="cb11-79"><a href="#cb11-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-80"><a href="#cb11-80"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb11-81"><a href="#cb11-81"></a>    <span class="at">var =</span> <span class="st">"ASEV"</span>,</span>
+<span id="cb11-82"><a href="#cb11-82"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb11-83"><a href="#cb11-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-84"><a href="#cb11-84"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AESEV"</span>, <span class="at">indent =</span> 2L)</span>
+<span id="cb11-85"><a href="#cb11-85"></a></span>
+<span id="cb11-86"><a href="#cb11-86"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb11-87"><a href="#cb11-87"></a>  <span class="fu">build_table</span>(</span>
+<span id="cb11-88"><a href="#cb11-88"></a>    adae,</span>
+<span id="cb11-89"><a href="#cb11-89"></a>    <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb11-90"><a href="#cb11-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-91"><a href="#cb11-91"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-92"><a href="#cb11-92"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-93"><a href="#cb11-93"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb11-94"><a href="#cb11-94"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-97"><a href="#cb11-97"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb11-98"><a href="#cb11-98"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb11-99"><a href="#cb11-99"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-100"><a href="#cb11-100"></a>  )</span>
+<span id="cb11-101"><a href="#cb11-101"></a></span>
+<span id="cb11-102"><a href="#cb11-102"></a>result</span>
+<span id="cb11-103"><a href="#cb11-103"></a><span class="in">```</span></span>
+<span id="cb11-104"><a href="#cb11-104"></a></span>
+<span id="cb11-105"><a href="#cb11-105"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-106"><a href="#cb11-106"></a></span>
+<span id="cb11-107"><a href="#cb11-107"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-108"><a href="#cb11-108"></a></span>
+<span id="cb11-109"><a href="#cb11-109"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-110"><a href="#cb11-110"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb11-111"><a href="#cb11-111"></a></span>
+<span id="cb11-112"><a href="#cb11-112"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb11-113"><a href="#cb11-113"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-114"><a href="#cb11-114"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-115"><a href="#cb11-115"></a></span>
+<span id="cb11-116"><a href="#cb11-116"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb11-117"><a href="#cb11-117"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb11-118"><a href="#cb11-118"></a></span>
+<span id="cb11-119"><a href="#cb11-119"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb11-120"><a href="#cb11-120"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb11-121"><a href="#cb11-121"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb11-122"><a href="#cb11-122"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb11-123"><a href="#cb11-123"></a>    <span class="at">code =</span></span>
+<span id="cb11-124"><a href="#cb11-124"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb11-125"><a href="#cb11-125"></a><span class="st">      ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb11-126"><a href="#cb11-126"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-127"><a href="#cb11-127"></a>  ),</span>
+<span id="cb11-128"><a href="#cb11-128"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb11-129"><a href="#cb11-129"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb11-130"><a href="#cb11-130"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb11-131"><a href="#cb11-131"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb11-132"><a href="#cb11-132"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb11-133"><a href="#cb11-133"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb11-134"><a href="#cb11-134"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb11-135"><a href="#cb11-135"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb11-136"><a href="#cb11-136"></a>      ),</span>
+<span id="cb11-137"><a href="#cb11-137"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb11-138"><a href="#cb11-138"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb11-139"><a href="#cb11-139"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb11-140"><a href="#cb11-140"></a>      ),</span>
+<span id="cb11-141"><a href="#cb11-141"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb11-142"><a href="#cb11-142"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb11-143"><a href="#cb11-143"></a>        <span class="at">selected =</span> <span class="st">"AESEV"</span></span>
+<span id="cb11-144"><a href="#cb11-144"></a>      )</span>
+<span id="cb11-145"><a href="#cb11-145"></a>    )</span>
+<span id="cb11-146"><a href="#cb11-146"></a>  )</span>
+<span id="cb11-147"><a href="#cb11-147"></a>)</span>
+<span id="cb11-148"><a href="#cb11-148"></a></span>
+<span id="cb11-149"><a href="#cb11-149"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb11-150"><a href="#cb11-150"></a><span class="in">```</span></span>
+<span id="cb11-151"><a href="#cb11-151"></a></span>
+<span id="cb11-152"><a href="#cb11-152"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-153"><a href="#cb11-153"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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diff --git a/stable/tables/adverse-events/aet04.html b/stable/tables/adverse-events/aet04.html
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+++ b/stable/tables/adverse-events/aet04.html
@@ -0,0 +1,3975 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET04</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events by Highest NCI CTCAE Grade</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Fill-In <br> of Treatment Groups</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Fill-In <br> of Grades</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Collapsing <br> of Grades</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table Using Worst Grade <br> Flags from ADAE</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Table with an Incidence Rate <br><span class="math inline">\(\geq\)</span> 40%, Totals Restricted</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Table with an Incidence Rate <br><span class="math inline">\(\geq\)</span> X%, Totals Unrestricted</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Table with an Incidence <br> Rate <span class="math inline">\(\geq\)</span> 58 Patients</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false">Table with a Difference in <br> Incidence Rate <span class="math inline">\(\geq\)</span> 10%</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false">Table with an Incidence Rate <br><span class="math inline">\(\geq\)</span> 5%, SOCs &lt; 5% Removed</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-12-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-12" role="tab" aria-controls="tabset-1-12" aria-selected="false">Table with an Incidence Rate <span class="math inline">\(\geq\)</span> 40%, <br> All SOCs w/o Preferred Terms Removed</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-13-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-13" role="tab" aria-controls="tabset-1-13" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-14-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-14" role="tab" aria-controls="tabset-1-14" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet04_cache/html/setup_0ead04e586611b12f3b8df170991bd2b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(TRT01A <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    AETOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  )</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a><span class="co"># Pre-Processing</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="st">"Grade 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="st">"Grade 3-4"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="st">"Grade 5"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>adae<span class="sc">$</span>TOTAL_VAR <span class="ot">&lt;-</span> <span class="st">"- Any adverse events - "</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="co"># Helper function to avoid filtering also the first part of the table, where general information is given.</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>my_row_condition <span class="ot">&lt;-</span> <span class="cf">function</span>(row_fnc_condition) {</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="cf">function</span>(table_row) {</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="cf">if</span> (<span class="fu">indent_mod</span>(table_row) <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="fu">return</span>(<span class="cn">TRUE</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    } <span class="cf">else</span> {</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      <span class="fu">row_fnc_condition</span>(table_row)</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    }</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  }</span>
+<span id="cb1-37"><a href="#cb1-37"></a>}</span>
+<span id="cb1-38"><a href="#cb1-38"></a></span>
+<span id="cb1-39"><a href="#cb1-39"></a><span class="co"># Helper function to calculate sum from first nested row</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>score_all_sum <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  cleaf <span class="ot">&lt;-</span> <span class="fu">collect_leaves</span>(tt)[[<span class="dv">1</span>]]</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="cf">if</span> (<span class="fu">NROW</span>(cleaf) <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="fu">stop</span>(<span class="st">"score_all_sum score function used at subtable ["</span>, <span class="fu">obj_name</span>(tt), <span class="st">"] that has no content."</span>)</span>
+<span id="cb1-44"><a href="#cb1-44"></a>  }</span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">sum</span>(<span class="fu">sapply</span>(<span class="fu">row_values</span>(cleaf), <span class="cf">function</span>(cv) cv[<span class="dv">1</span>]))</span>
+<span id="cb1-46"><a href="#cb1-46"></a>}</span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a><span class="co"># Raw table used by variant 8/10</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>raw_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb1-56"><a href="#cb1-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb1-62"><a href="#cb1-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-63"><a href="#cb1-63"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb1-64"><a href="#cb1-64"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb1-67"><a href="#cb1-67"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-68"><a href="#cb1-68"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb1-69"><a href="#cb1-69"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb1-70"><a href="#cb1-70"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb1-71"><a href="#cb1-71"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-72"><a href="#cb1-72"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb1-73"><a href="#cb1-73"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb1-74"><a href="#cb1-74"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb1-75"><a href="#cb1-75"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-76"><a href="#cb1-76"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb1-77"><a href="#cb1-77"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb1-78"><a href="#cb1-78"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb1-79"><a href="#cb1-79"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb1-80"><a href="#cb1-80"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb1-81"><a href="#cb1-81"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb1-82"><a href="#cb1-82"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-83"><a href="#cb1-83"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb1-84"><a href="#cb1-84"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb1-85"><a href="#cb1-85"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb1-86"><a href="#cb1-86"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb1-87"><a href="#cb1-87"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb1-88"><a href="#cb1-88"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-89"><a href="#cb1-89"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb1-90"><a href="#cb1-90"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb1-91"><a href="#cb1-91"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb1-92"><a href="#cb1-92"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb1-93"><a href="#cb1-93"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-94"><a href="#cb1-94"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-95"><a href="#cb1-95"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb1-96"><a href="#cb1-96"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-97"><a href="#cb1-97"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb1-98"><a href="#cb1-98"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb1-99"><a href="#cb1-99"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb1-100"><a href="#cb1-100"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-101"><a href="#cb1-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-102"><a href="#cb1-102"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb1-103"><a href="#cb1-103"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb1-104"><a href="#cb1-104"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb1-105"><a href="#cb1-105"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-106"><a href="#cb1-106"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant1_6e492b0ed816172761e914fde365ce0c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb2-34"><a href="#cb2-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb2-40"><a href="#cb2-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb2-45"><a href="#cb2-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb2-47"><a href="#cb2-47"></a></span>
+<span id="cb2-48"><a href="#cb2-48"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb2-49"><a href="#cb2-49"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-50"><a href="#cb2-50"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-51"><a href="#cb2-51"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-52"><a href="#cb2-52"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-53"><a href="#cb2-53"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb2-54"><a href="#cb2-54"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-55"><a href="#cb2-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-56"><a href="#cb2-56"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-58"><a href="#cb2-58"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb2-59"><a href="#cb2-59"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-60"><a href="#cb2-60"></a>  )</span>
+<span id="cb2-61"><a href="#cb2-61"></a></span>
+<span id="cb2-62"><a href="#cb2-62"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant2_d29a0634997895d965908745968c3862">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>adae2 <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ACTARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb4-36"><a href="#cb4-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb4-42"><a href="#cb4-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb4-44"><a href="#cb4-44"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb4-47"><a href="#cb4-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb4-49"><a href="#cb4-49"></a></span>
+<span id="cb4-50"><a href="#cb4-50"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>  <span class="fu">build_table</span>(adae2, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb4-52"><a href="#cb4-52"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-53"><a href="#cb4-53"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-54"><a href="#cb4-54"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb4-55"><a href="#cb4-55"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb4-56"><a href="#cb4-56"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-57"><a href="#cb4-57"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-58"><a href="#cb4-58"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-59"><a href="#cb4-59"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb4-60"><a href="#cb4-60"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb4-61"><a href="#cb4-61"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-62"><a href="#cb4-62"></a>  )</span>
+<span id="cb4-63"><a href="#cb4-63"></a></span>
+<span id="cb4-64"><a href="#cb4-64"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)       0              0       
+                            Grade 1-2        10 (7.5%)        0              0       
+                            1                5 (3.7%)         0              0       
+                            2                5 (3.7%)         0              0       
+                            Grade 3-4       26 (19.4%)        0              0       
+                            3                13 (9.7%)        0              0       
+                            4                13 (9.7%)        0              0       
+                            Grade 5         64 (47.8%)        0              0       
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)        0              0       
+                            Grade 1-2       68 (50.7%)        0              0       
+                            1               27 (20.1%)        0              0       
+                            2               41 (30.6%)        0              0       
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)        0              0       
+                            Grade 1-2       45 (33.6%)        0              0       
+                            1               45 (33.6%)        0              0       
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)        0              0       
+                            Grade 1-2       41 (30.6%)        0              0       
+                            2               41 (30.6%)        0              0       
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)        0              0       
+                            Grade 3-4       22 (16.4%)        0              0       
+                            3               22 (16.4%)        0              0       
+                            Grade 5         42 (31.3%)        0              0       
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)        0              0       
+                            Grade 5         42 (31.3%)        0              0       
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)        0              0       
+                            Grade 3-4       38 (28.4%)        0              0       
+                            3               38 (28.4%)        0              0       
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)        0              0       
+                            Grade 1-2       23 (17.2%)        0              0       
+                            1               23 (17.2%)        0              0       
+                            Grade 3-4       39 (29.1%)        0              0       
+                            3               39 (29.1%)        0              0       
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)        0              0       
+                            Grade 3-4       39 (29.1%)        0              0       
+                            3               39 (29.1%)        0              0       
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)        0              0       
+                            Grade 1-2       38 (28.4%)        0              0       
+                            1               38 (28.4%)        0              0       
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)        0              0       
+                            Grade 5         38 (28.4%)        0              0       
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)        0              0       
+                            Grade 5         38 (28.4%)        0              0       
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)        0              0       
+                            Grade 1-2       37 (27.6%)        0              0       
+                            1               37 (27.6%)        0              0       
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)        0              0       
+                            Grade 1-2       37 (27.6%)        0              0       
+                            1               37 (27.6%)        0              0       
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)        0              0       
+                            Grade 3-4       36 (26.9%)        0              0       
+                            4               36 (26.9%)        0              0       
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)        0              0       
+                            Grade 3-4       36 (26.9%)        0              0       
+                            4               36 (26.9%)        0              0       
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)        0              0       
+                            Grade 1-2       28 (20.9%)        0              0       
+                            2               28 (20.9%)        0              0       
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)        0              0       
+                            Grade 1-2       28 (20.9%)        0              0       
+                            2               28 (20.9%)        0              0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant3_d5316cc07829ab5410a9adde5a644f46">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb6-8"><a href="#cb6-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb6-19"><a href="#cb6-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb6-38"><a href="#cb6-38"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb6-39"><a href="#cb6-39"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb6-40"><a href="#cb6-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb6-45"><a href="#cb6-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb6-47"><a href="#cb6-47"></a></span>
+<span id="cb6-48"><a href="#cb6-48"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb6-49"><a href="#cb6-49"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-51"><a href="#cb6-51"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb6-52"><a href="#cb6-52"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb6-53"><a href="#cb6-53"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-54"><a href="#cb6-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-55"><a href="#cb6-55"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-56"><a href="#cb6-56"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb6-57"><a href="#cb6-57"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb6-58"><a href="#cb6-58"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a>  )</span>
+<span id="cb6-60"><a href="#cb6-60"></a></span>
+<span id="cb6-61"><a href="#cb6-61"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            1                    0            0              0       
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            2                    0            0              0       
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            4                    0            0              0       
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            1                    0            0              0       
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            1                    0            0              0       
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5              0            0              0       
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4            0            0              0       
+                            3                    0            0              0       
+                            4                    0            0              0       
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            3                    0            0              0       
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 5              0            0              0       
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 1-2            0            0              0       
+                            1                    0            0              0       
+                            2                    0            0              0       
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            3                    0            0              0       
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 5              0            0              0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant4_2bdd9c809de04ec1dc38c783589e783e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>grade_groups_1 <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="st">"Grade 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="st">"Grade 3-5"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>)</span>
+<span id="cb8-4"><a href="#cb8-4"></a>)</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb8-13"><a href="#cb8-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb8-19"><a href="#cb8-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-20"><a href="#cb8-20"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">grade_groups =</span> grade_groups_1,</span>
+<span id="cb8-23"><a href="#cb8-23"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb8-24"><a href="#cb8-24"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb8-45"><a href="#cb8-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">grade_groups =</span> grade_groups_1,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb8-50"><a href="#cb8-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb8-52"><a href="#cb8-52"></a></span>
+<span id="cb8-53"><a href="#cb8-53"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb8-64"><a href="#cb8-64"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  )</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-5       90 (67.2%)    83 (61.9%)     93 (70.5%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            5               64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-5       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-5       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-5       64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            5               42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 3-5       42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            5               42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-5       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 3-5       38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            5               38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 3-5       38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            5               38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-5       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-5       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-hash="aet04_cache/html/variant5_81964a015b6d2228b9b4911db05367f6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># No Worst Grade Flags found in the ADAE data set.</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant6_5059c3f132ebb6986b585c331cd9f0e5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="co"># Simple wrapper to return subset ADAE to a threshold of xx%.</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb11-3"><a href="#cb11-3"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ACTARM)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb11-7"><a href="#cb11-7"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ACTARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb11-8"><a href="#cb11-8"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb11-10"><a href="#cb11-10"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-11"><a href="#cb11-11"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb11-13"><a href="#cb11-13"></a></span>
+<span id="cb11-14"><a href="#cb11-14"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb11-15"><a href="#cb11-15"></a>    anl_terms,</span>
+<span id="cb11-16"><a href="#cb11-16"></a>    n_per_arm,</span>
+<span id="cb11-17"><a href="#cb11-17"></a>    <span class="at">by =</span> <span class="st">"ACTARM"</span></span>
+<span id="cb11-18"><a href="#cb11-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-19"><a href="#cb11-19"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb11-20"><a href="#cb11-20"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb11-21"><a href="#cb11-21"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-22"><a href="#cb11-22"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb11-23"><a href="#cb11-23"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb11-24"><a href="#cb11-24"></a>    <span class="fu">unique</span>()</span>
+<span id="cb11-25"><a href="#cb11-25"></a></span>
+<span id="cb11-26"><a href="#cb11-26"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb11-27"><a href="#cb11-27"></a>    anl_terms,</span>
+<span id="cb11-28"><a href="#cb11-28"></a>    adae,</span>
+<span id="cb11-29"><a href="#cb11-29"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>  )</span>
+<span id="cb11-31"><a href="#cb11-31"></a>  anl</span>
+<span id="cb11-32"><a href="#cb11-32"></a>}</span>
+<span id="cb11-33"><a href="#cb11-33"></a></span>
+<span id="cb11-34"><a href="#cb11-34"></a>adae6 <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae, <span class="at">cutoff_rate =</span> <span class="fl">0.4</span>)</span>
+<span id="cb11-35"><a href="#cb11-35"></a></span>
+<span id="cb11-36"><a href="#cb11-36"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb11-41"><a href="#cb11-41"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-42"><a href="#cb11-42"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb11-43"><a href="#cb11-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-44"><a href="#cb11-44"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb11-46"><a href="#cb11-46"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb11-47"><a href="#cb11-47"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb11-48"><a href="#cb11-48"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb11-49"><a href="#cb11-49"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-50"><a href="#cb11-50"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb11-51"><a href="#cb11-51"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb11-52"><a href="#cb11-52"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb11-53"><a href="#cb11-53"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb11-54"><a href="#cb11-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-55"><a href="#cb11-55"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-56"><a href="#cb11-56"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-57"><a href="#cb11-57"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-58"><a href="#cb11-58"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb11-59"><a href="#cb11-59"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb11-60"><a href="#cb11-60"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb11-61"><a href="#cb11-61"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb11-62"><a href="#cb11-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-63"><a href="#cb11-63"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-64"><a href="#cb11-64"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb11-65"><a href="#cb11-65"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb11-66"><a href="#cb11-66"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb11-67"><a href="#cb11-67"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb11-68"><a href="#cb11-68"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb11-69"><a href="#cb11-69"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-70"><a href="#cb11-70"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb11-71"><a href="#cb11-71"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb11-72"><a href="#cb11-72"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb11-73"><a href="#cb11-73"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb11-74"><a href="#cb11-74"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb11-75"><a href="#cb11-75"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-76"><a href="#cb11-76"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb11-77"><a href="#cb11-77"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb11-78"><a href="#cb11-78"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb11-79"><a href="#cb11-79"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb11-80"><a href="#cb11-80"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-81"><a href="#cb11-81"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb11-82"><a href="#cb11-82"></a></span>
+<span id="cb11-83"><a href="#cb11-83"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb11-84"><a href="#cb11-84"></a>  <span class="fu">build_table</span>(adae6, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb11-85"><a href="#cb11-85"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-86"><a href="#cb11-86"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-87"><a href="#cb11-87"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-88"><a href="#cb11-88"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb11-89"><a href="#cb11-89"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-90"><a href="#cb11-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-91"><a href="#cb11-91"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb11-92"><a href="#cb11-92"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb11-93"><a href="#cb11-93"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb11-94"><a href="#cb11-94"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a>  )</span>
+<span id="cb11-96"><a href="#cb11-96"></a></span>
+<span id="cb11-97"><a href="#cb11-97"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-hash="aet04_cache/html/variant7_f451bcdb815fe2019a4bb05264773fca">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="co"># Variant 7 was not created.</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a><span class="co"># With this variant, the SOC level is not trimmed (even if there are no terms left).</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<div class="cell" data-test="{&quot;result_v8&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant8_068e85d25c6448889f6e851beb5e2291">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>cutoff <span class="ot">&lt;-</span> 58L</span>
+<span id="cb14-2"><a href="#cb14-2"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_count_in_any_col</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb14-3"><a href="#cb14-3"></a></span>
+<span id="cb14-4"><a href="#cb14-4"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-test="{&quot;result_v9&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant9_ffa3b20fbca27ebf77d1e5b4768a2e0a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a>cutoff <span class="ot">&lt;-</span> <span class="fl">0.1</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb16-3"><a href="#cb16-3"></a></span>
+<span id="cb16-4"><a href="#cb16-4"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<div class="cell" data-hash="aet04_cache/html/variant10_3ef3741c6152f176082dd37ff2f47869">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a><span class="co"># Variant 10 was not done</span></span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="co"># With this variant, SOC levels above the threshold are still in the table even if</span></span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="co"># there are no terms left.</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-12" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-12-tab">
+<div class="cell" data-test="{&quot;result_v11&quot;:&quot;result&quot;}" data-hash="aet04_cache/html/variant11_20bb091f5c15f94b27fb9ad2d5c9a4c3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb19"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb19-1"><a href="#cb19-1"></a>cutoff <span class="ot">&lt;-</span> <span class="fl">0.4</span></span>
+<span id="cb19-2"><a href="#cb19-2"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb19-3"><a href="#cb19-3"></a></span>
+<span id="cb19-4"><a href="#cb19-4"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb19-5"><a href="#cb19-5"></a></span>
+<span id="cb19-6"><a href="#cb19-6"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                                            
+  MedDRA Preferred Term                      A: Drug X    B: Placebo   C: Combination
+                            Grade             (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+- Any adverse events -                                                               
+                            - Any Grade -   100 (74.6%)   98 (73.1%)    103 (78.0%)  
+                            Grade 1-2        10 (7.5%)    15 (11.2%)     10 (7.6%)   
+                            1                5 (3.7%)      7 (5.2%)       4 (3.0%)   
+                            2                5 (3.7%)      8 (6.0%)       6 (4.5%)   
+                            Grade 3-4       26 (19.4%)    31 (23.1%)     29 (22.0%)  
+                            3                13 (9.7%)    13 (9.7%)      14 (10.6%)  
+                            4                13 (9.7%)    18 (13.4%)     15 (11.4%)  
+                            Grade 5         64 (47.8%)    52 (38.8%)     64 (48.5%)  
+cl A.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            Grade 1-2       68 (50.7%)    58 (43.3%)     76 (57.6%)  
+                            1               27 (20.1%)    19 (14.2%)     34 (25.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+  dcd A.1.1.1.1                                                                      
+                            - Any Grade -   45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            Grade 1-2       45 (33.6%)    31 (23.1%)     52 (39.4%)  
+                            1               45 (33.6%)    31 (23.1%)     52 (39.4%)  
+  dcd A.1.1.1.2                                                                      
+                            - Any Grade -   41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            Grade 1-2       41 (30.6%)    39 (29.1%)     42 (31.8%)  
+                            2               41 (30.6%)    39 (29.1%)     42 (31.8%)  
+cl B.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   62 (46.3%)    56 (41.8%)     74 (56.1%)  
+                            Grade 1-2       23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            1               23 (17.2%)    22 (16.4%)     28 (21.2%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+  dcd B.2.2.3.1                                                                      
+                            - Any Grade -   38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            Grade 1-2       38 (28.4%)    40 (29.9%)     45 (34.1%)  
+                            1               38 (28.4%)    40 (29.9%)     45 (34.1%)  
+  dcd B.2.1.2.1                                                                      
+                            - Any Grade -   39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            Grade 3-4       39 (29.1%)    34 (25.4%)     46 (34.8%)  
+                            3               39 (29.1%)    34 (25.4%)     46 (34.8%)  
+cl D.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   64 (47.8%)    54 (40.3%)     68 (51.5%)  
+                            Grade 3-4       22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            3               22 (16.4%)    22 (16.4%)     22 (16.7%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.1.1                                                                      
+                            - Any Grade -   42 (31.3%)    32 (23.9%)     46 (34.8%)  
+                            Grade 5         42 (31.3%)    32 (23.9%)     46 (34.8%)  
+  dcd D.1.1.4.2                                                                      
+                            - Any Grade -   38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            Grade 3-4       38 (28.4%)    34 (25.4%)     40 (30.3%)  
+                            3               38 (28.4%)    34 (25.4%)     40 (30.3%)  
+cl D.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+  dcd D.2.1.5.3                                                                      
+                            - Any Grade -   37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            Grade 1-2       37 (27.6%)    46 (34.3%)     50 (37.9%)  
+                            1               37 (27.6%)    46 (34.3%)     50 (37.9%)  
+cl C.2                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+  dcd C.2.1.2.1                                                                      
+                            - Any Grade -   28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            Grade 1-2       28 (20.9%)    36 (26.9%)     48 (36.4%)  
+                            2               28 (20.9%)    36 (26.9%)     48 (36.4%)  
+cl B.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+  dcd B.1.1.1.1                                                                      
+                            - Any Grade -   38 (28.4%)    37 (27.6%)     36 (27.3%)  
+                            Grade 5         38 (28.4%)    37 (27.6%)     36 (27.3%)  
+cl C.1                                                                               
+  - Overall -                                                                        
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  
+  dcd C.1.1.1.3                                                                      
+                            - Any Grade -   36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            Grade 3-4       36 (26.9%)    34 (25.4%)     36 (27.3%)  
+                            4               36 (26.9%)    34 (25.4%)     36 (27.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-13" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-13-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet04_cache/html/teal_32ea9d5236dea3e30cc46a383cef95de">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb21"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb21-1"><a href="#cb21-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb21-2"><a href="#cb21-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb21-3"><a href="#cb21-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb21-4"><a href="#cb21-4"></a><span class="fu">library</span>(tern)</span>
+<span id="cb21-5"><a href="#cb21-5"></a></span>
+<span id="cb21-6"><a href="#cb21-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb21-7"><a href="#cb21-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb21-8"><a href="#cb21-8"></a></span>
+<span id="cb21-9"><a href="#cb21-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb21-10"><a href="#cb21-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb21-11"><a href="#cb21-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb21-12"><a href="#cb21-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb21-13"><a href="#cb21-13"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb21-14"><a href="#cb21-14"></a><span class="st">    ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb21-15"><a href="#cb21-15"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb21-16"><a href="#cb21-16"></a>  ),</span>
+<span id="cb21-17"><a href="#cb21-17"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb21-18"><a href="#cb21-18"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb21-19"><a href="#cb21-19"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb21-20"><a href="#cb21-20"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb21-21"><a href="#cb21-21"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb21-22"><a href="#cb21-22"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-23"><a href="#cb21-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb21-24"><a href="#cb21-24"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb21-25"><a href="#cb21-25"></a>      ),</span>
+<span id="cb21-26"><a href="#cb21-26"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-27"><a href="#cb21-27"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb21-28"><a href="#cb21-28"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb21-29"><a href="#cb21-29"></a>      ),</span>
+<span id="cb21-30"><a href="#cb21-30"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-31"><a href="#cb21-31"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb21-32"><a href="#cb21-32"></a>        <span class="at">selected =</span> <span class="st">"AETOXGR"</span></span>
+<span id="cb21-33"><a href="#cb21-33"></a>      )</span>
+<span id="cb21-34"><a href="#cb21-34"></a>    )</span>
+<span id="cb21-35"><a href="#cb21-35"></a>  )</span>
+<span id="cb21-36"><a href="#cb21-36"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:20:58.4365 pid:11096 token:[] teal.modules.clinical Initializing tm_t_events_by_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb23"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb23-1"><a href="#cb23-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet04_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-14" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-14-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet04_cache/html/sessioninfo_38fa04797b851cee580f71d61415c842">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb24"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb24-1"><a href="#cb24-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet04_cache/html/snapshot_31b3af09d2db78c0cee73d56e6b3d7d8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb26"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb26-1"><a href="#cb26-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb26-2"><a href="#cb26-2"></a></span>
+<span id="cb26-3"><a href="#cb26-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb26-4"><a href="#cb26-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb26-5"><a href="#cb26-5"></a></span>
+<span id="cb26-6"><a href="#cb26-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb26-7"><a href="#cb26-7"></a></span>
+<span id="cb26-8"><a href="#cb26-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb26-9"><a href="#cb26-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb26-10"><a href="#cb26-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb26-11"><a href="#cb26-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+      }
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
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+          citeDiv.classList.add('csl-entry');
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+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet04_pi.html" class="pagination-link">
+        <span class="nav-page-text">AET04_PI</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb27" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb27-1"><a href="#cb27-1"></a><span class="co">---</span></span>
+<span id="cb27-2"><a href="#cb27-2"></a><span class="an">title:</span><span class="co"> AET04</span></span>
+<span id="cb27-3"><a href="#cb27-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events by Highest NCI CTCAE Grade</span></span>
+<span id="cb27-4"><a href="#cb27-4"></a><span class="co">---</span></span>
+<span id="cb27-5"><a href="#cb27-5"></a></span>
+<span id="cb27-6"><a href="#cb27-6"></a>------------------------------------------------------------------------</span>
+<span id="cb27-7"><a href="#cb27-7"></a></span>
+<span id="cb27-8"><a href="#cb27-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb27-9"><a href="#cb27-9"></a></span>
+<span id="cb27-10"><a href="#cb27-10"></a>::: panel-tabset</span>
+<span id="cb27-11"><a href="#cb27-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb27-12"><a href="#cb27-12"></a></span>
+<span id="cb27-13"><a href="#cb27-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb27-14"><a href="#cb27-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb27-15"><a href="#cb27-15"></a></span>
+<span id="cb27-16"><a href="#cb27-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb27-17"><a href="#cb27-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb27-18"><a href="#cb27-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb27-19"><a href="#cb27-19"></a></span>
+<span id="cb27-20"><a href="#cb27-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb27-21"><a href="#cb27-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb27-22"><a href="#cb27-22"></a></span>
+<span id="cb27-23"><a href="#cb27-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb27-24"><a href="#cb27-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(TRT01A <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>)</span>
+<span id="cb27-25"><a href="#cb27-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae) <span class="sc">%&gt;%</span></span>
+<span id="cb27-26"><a href="#cb27-26"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb27-27"><a href="#cb27-27"></a>    <span class="at">AEBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb27-28"><a href="#cb27-28"></a>    <span class="at">AEDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb27-29"><a href="#cb27-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-30"><a href="#cb27-30"></a>  <span class="fu">filter</span>(</span>
+<span id="cb27-31"><a href="#cb27-31"></a>    ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb27-32"><a href="#cb27-32"></a>    AETOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb27-33"><a href="#cb27-33"></a>  )</span>
+<span id="cb27-34"><a href="#cb27-34"></a></span>
+<span id="cb27-35"><a href="#cb27-35"></a><span class="co"># Pre-Processing</span></span>
+<span id="cb27-36"><a href="#cb27-36"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb27-37"><a href="#cb27-37"></a>  <span class="st">"Grade 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb27-38"><a href="#cb27-38"></a>  <span class="st">"Grade 3-4"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb27-39"><a href="#cb27-39"></a>  <span class="st">"Grade 5"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb27-40"><a href="#cb27-40"></a>)</span>
+<span id="cb27-41"><a href="#cb27-41"></a>adae<span class="sc">$</span>TOTAL_VAR <span class="ot">&lt;-</span> <span class="st">"- Any adverse events - "</span></span>
+<span id="cb27-42"><a href="#cb27-42"></a></span>
+<span id="cb27-43"><a href="#cb27-43"></a><span class="co"># Helper function to avoid filtering also the first part of the table, where general information is given.</span></span>
+<span id="cb27-44"><a href="#cb27-44"></a>my_row_condition <span class="ot">&lt;-</span> <span class="cf">function</span>(row_fnc_condition) {</span>
+<span id="cb27-45"><a href="#cb27-45"></a>  <span class="cf">function</span>(table_row) {</span>
+<span id="cb27-46"><a href="#cb27-46"></a>    <span class="cf">if</span> (<span class="fu">indent_mod</span>(table_row) <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb27-47"><a href="#cb27-47"></a>      <span class="fu">return</span>(<span class="cn">TRUE</span>)</span>
+<span id="cb27-48"><a href="#cb27-48"></a>    } <span class="cf">else</span> {</span>
+<span id="cb27-49"><a href="#cb27-49"></a>      <span class="fu">row_fnc_condition</span>(table_row)</span>
+<span id="cb27-50"><a href="#cb27-50"></a>    }</span>
+<span id="cb27-51"><a href="#cb27-51"></a>  }</span>
+<span id="cb27-52"><a href="#cb27-52"></a>}</span>
+<span id="cb27-53"><a href="#cb27-53"></a></span>
+<span id="cb27-54"><a href="#cb27-54"></a><span class="co"># Helper function to calculate sum from first nested row</span></span>
+<span id="cb27-55"><a href="#cb27-55"></a>score_all_sum <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb27-56"><a href="#cb27-56"></a>  cleaf <span class="ot">&lt;-</span> <span class="fu">collect_leaves</span>(tt)[[<span class="dv">1</span>]]</span>
+<span id="cb27-57"><a href="#cb27-57"></a>  <span class="cf">if</span> (<span class="fu">NROW</span>(cleaf) <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb27-58"><a href="#cb27-58"></a>    <span class="fu">stop</span>(<span class="st">"score_all_sum score function used at subtable ["</span>, <span class="fu">obj_name</span>(tt), <span class="st">"] that has no content."</span>)</span>
+<span id="cb27-59"><a href="#cb27-59"></a>  }</span>
+<span id="cb27-60"><a href="#cb27-60"></a>  <span class="fu">sum</span>(<span class="fu">sapply</span>(<span class="fu">row_values</span>(cleaf), <span class="cf">function</span>(cv) cv[<span class="dv">1</span>]))</span>
+<span id="cb27-61"><a href="#cb27-61"></a>}</span>
+<span id="cb27-62"><a href="#cb27-62"></a></span>
+<span id="cb27-63"><a href="#cb27-63"></a><span class="co"># Raw table used by variant 8/10</span></span>
+<span id="cb27-64"><a href="#cb27-64"></a>raw_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-65"><a href="#cb27-65"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-66"><a href="#cb27-66"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-67"><a href="#cb27-67"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-68"><a href="#cb27-68"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-69"><a href="#cb27-69"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-70"><a href="#cb27-70"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-71"><a href="#cb27-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-72"><a href="#cb27-72"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-73"><a href="#cb27-73"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-74"><a href="#cb27-74"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-75"><a href="#cb27-75"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-76"><a href="#cb27-76"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-77"><a href="#cb27-77"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-78"><a href="#cb27-78"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-79"><a href="#cb27-79"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-80"><a href="#cb27-80"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-81"><a href="#cb27-81"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-82"><a href="#cb27-82"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-83"><a href="#cb27-83"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-84"><a href="#cb27-84"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-85"><a href="#cb27-85"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-86"><a href="#cb27-86"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-87"><a href="#cb27-87"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-88"><a href="#cb27-88"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-89"><a href="#cb27-89"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-90"><a href="#cb27-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-91"><a href="#cb27-91"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-92"><a href="#cb27-92"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-93"><a href="#cb27-93"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-94"><a href="#cb27-94"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-95"><a href="#cb27-95"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-96"><a href="#cb27-96"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-97"><a href="#cb27-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-98"><a href="#cb27-98"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-99"><a href="#cb27-99"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-100"><a href="#cb27-100"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-101"><a href="#cb27-101"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-102"><a href="#cb27-102"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-103"><a href="#cb27-103"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-104"><a href="#cb27-104"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-105"><a href="#cb27-105"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-106"><a href="#cb27-106"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-107"><a href="#cb27-107"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-108"><a href="#cb27-108"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-109"><a href="#cb27-109"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-110"><a href="#cb27-110"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-111"><a href="#cb27-111"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb27-112"><a href="#cb27-112"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-113"><a href="#cb27-113"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-114"><a href="#cb27-114"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-115"><a href="#cb27-115"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-116"><a href="#cb27-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-117"><a href="#cb27-117"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-118"><a href="#cb27-118"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-119"><a href="#cb27-119"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-120"><a href="#cb27-120"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-121"><a href="#cb27-121"></a>  )</span>
+<span id="cb27-122"><a href="#cb27-122"></a><span class="in">```</span></span>
+<span id="cb27-123"><a href="#cb27-123"></a></span>
+<span id="cb27-124"><a href="#cb27-124"></a><span class="fu">## Standard Table</span></span>
+<span id="cb27-125"><a href="#cb27-125"></a></span>
+<span id="cb27-126"><a href="#cb27-126"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb27-127"><a href="#cb27-127"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-128"><a href="#cb27-128"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-129"><a href="#cb27-129"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-130"><a href="#cb27-130"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-131"><a href="#cb27-131"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-132"><a href="#cb27-132"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-133"><a href="#cb27-133"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-134"><a href="#cb27-134"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-135"><a href="#cb27-135"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-136"><a href="#cb27-136"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-137"><a href="#cb27-137"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-138"><a href="#cb27-138"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-139"><a href="#cb27-139"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-140"><a href="#cb27-140"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-141"><a href="#cb27-141"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-142"><a href="#cb27-142"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-143"><a href="#cb27-143"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-144"><a href="#cb27-144"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-145"><a href="#cb27-145"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-146"><a href="#cb27-146"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-147"><a href="#cb27-147"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-148"><a href="#cb27-148"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-149"><a href="#cb27-149"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-150"><a href="#cb27-150"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-151"><a href="#cb27-151"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-152"><a href="#cb27-152"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-153"><a href="#cb27-153"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-154"><a href="#cb27-154"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-155"><a href="#cb27-155"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-156"><a href="#cb27-156"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-157"><a href="#cb27-157"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-158"><a href="#cb27-158"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-159"><a href="#cb27-159"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-160"><a href="#cb27-160"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-161"><a href="#cb27-161"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-162"><a href="#cb27-162"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-163"><a href="#cb27-163"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-164"><a href="#cb27-164"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-165"><a href="#cb27-165"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-166"><a href="#cb27-166"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-167"><a href="#cb27-167"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-168"><a href="#cb27-168"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-169"><a href="#cb27-169"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-170"><a href="#cb27-170"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-171"><a href="#cb27-171"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-172"><a href="#cb27-172"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb27-173"><a href="#cb27-173"></a></span>
+<span id="cb27-174"><a href="#cb27-174"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb27-175"><a href="#cb27-175"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-176"><a href="#cb27-176"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb27-177"><a href="#cb27-177"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-178"><a href="#cb27-178"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-179"><a href="#cb27-179"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-180"><a href="#cb27-180"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-181"><a href="#cb27-181"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-182"><a href="#cb27-182"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-183"><a href="#cb27-183"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-184"><a href="#cb27-184"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-185"><a href="#cb27-185"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-186"><a href="#cb27-186"></a>  )</span>
+<span id="cb27-187"><a href="#cb27-187"></a></span>
+<span id="cb27-188"><a href="#cb27-188"></a>result</span>
+<span id="cb27-189"><a href="#cb27-189"></a><span class="in">```</span></span>
+<span id="cb27-190"><a href="#cb27-190"></a></span>
+<span id="cb27-191"><a href="#cb27-191"></a><span class="fu">## Table with Fill-In &lt;br/&gt; of Treatment Groups</span></span>
+<span id="cb27-192"><a href="#cb27-192"></a></span>
+<span id="cb27-193"><a href="#cb27-193"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb27-194"><a href="#cb27-194"></a>adae2 <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ACTARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb27-195"><a href="#cb27-195"></a></span>
+<span id="cb27-196"><a href="#cb27-196"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-197"><a href="#cb27-197"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-198"><a href="#cb27-198"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-199"><a href="#cb27-199"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-200"><a href="#cb27-200"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-201"><a href="#cb27-201"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-202"><a href="#cb27-202"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-203"><a href="#cb27-203"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-204"><a href="#cb27-204"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-205"><a href="#cb27-205"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-206"><a href="#cb27-206"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-207"><a href="#cb27-207"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-208"><a href="#cb27-208"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-209"><a href="#cb27-209"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-210"><a href="#cb27-210"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-211"><a href="#cb27-211"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-212"><a href="#cb27-212"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-213"><a href="#cb27-213"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-214"><a href="#cb27-214"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-215"><a href="#cb27-215"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-216"><a href="#cb27-216"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-217"><a href="#cb27-217"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-218"><a href="#cb27-218"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-219"><a href="#cb27-219"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-220"><a href="#cb27-220"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-221"><a href="#cb27-221"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-222"><a href="#cb27-222"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-223"><a href="#cb27-223"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-224"><a href="#cb27-224"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-225"><a href="#cb27-225"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-226"><a href="#cb27-226"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-227"><a href="#cb27-227"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-228"><a href="#cb27-228"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-229"><a href="#cb27-229"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-230"><a href="#cb27-230"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-231"><a href="#cb27-231"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-232"><a href="#cb27-232"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-233"><a href="#cb27-233"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-234"><a href="#cb27-234"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-235"><a href="#cb27-235"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-236"><a href="#cb27-236"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-237"><a href="#cb27-237"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-238"><a href="#cb27-238"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-239"><a href="#cb27-239"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-240"><a href="#cb27-240"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-241"><a href="#cb27-241"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb27-242"><a href="#cb27-242"></a></span>
+<span id="cb27-243"><a href="#cb27-243"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb27-244"><a href="#cb27-244"></a>  <span class="fu">build_table</span>(adae2, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-245"><a href="#cb27-245"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb27-246"><a href="#cb27-246"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-247"><a href="#cb27-247"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-248"><a href="#cb27-248"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-249"><a href="#cb27-249"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-250"><a href="#cb27-250"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-251"><a href="#cb27-251"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-252"><a href="#cb27-252"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-253"><a href="#cb27-253"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-254"><a href="#cb27-254"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-255"><a href="#cb27-255"></a>  )</span>
+<span id="cb27-256"><a href="#cb27-256"></a></span>
+<span id="cb27-257"><a href="#cb27-257"></a>result</span>
+<span id="cb27-258"><a href="#cb27-258"></a><span class="in">```</span></span>
+<span id="cb27-259"><a href="#cb27-259"></a></span>
+<span id="cb27-260"><a href="#cb27-260"></a><span class="fu">## Table with Fill-In &lt;br/&gt; of Grades</span></span>
+<span id="cb27-261"><a href="#cb27-261"></a></span>
+<span id="cb27-262"><a href="#cb27-262"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb27-263"><a href="#cb27-263"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-264"><a href="#cb27-264"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-265"><a href="#cb27-265"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-266"><a href="#cb27-266"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-267"><a href="#cb27-267"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-268"><a href="#cb27-268"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-269"><a href="#cb27-269"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-270"><a href="#cb27-270"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-271"><a href="#cb27-271"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-272"><a href="#cb27-272"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-273"><a href="#cb27-273"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-274"><a href="#cb27-274"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-275"><a href="#cb27-275"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-276"><a href="#cb27-276"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-277"><a href="#cb27-277"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-278"><a href="#cb27-278"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-279"><a href="#cb27-279"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-280"><a href="#cb27-280"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-281"><a href="#cb27-281"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-282"><a href="#cb27-282"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-283"><a href="#cb27-283"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-284"><a href="#cb27-284"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-285"><a href="#cb27-285"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-286"><a href="#cb27-286"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-287"><a href="#cb27-287"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-288"><a href="#cb27-288"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-289"><a href="#cb27-289"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-290"><a href="#cb27-290"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-291"><a href="#cb27-291"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-292"><a href="#cb27-292"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-293"><a href="#cb27-293"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-294"><a href="#cb27-294"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-295"><a href="#cb27-295"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-296"><a href="#cb27-296"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-297"><a href="#cb27-297"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-298"><a href="#cb27-298"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-299"><a href="#cb27-299"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-300"><a href="#cb27-300"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-301"><a href="#cb27-301"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-302"><a href="#cb27-302"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-303"><a href="#cb27-303"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-304"><a href="#cb27-304"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-305"><a href="#cb27-305"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-306"><a href="#cb27-306"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-307"><a href="#cb27-307"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-308"><a href="#cb27-308"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb27-309"><a href="#cb27-309"></a></span>
+<span id="cb27-310"><a href="#cb27-310"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb27-311"><a href="#cb27-311"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-312"><a href="#cb27-312"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-313"><a href="#cb27-313"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-314"><a href="#cb27-314"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-315"><a href="#cb27-315"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-316"><a href="#cb27-316"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-317"><a href="#cb27-317"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-318"><a href="#cb27-318"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-319"><a href="#cb27-319"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-320"><a href="#cb27-320"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-321"><a href="#cb27-321"></a>  )</span>
+<span id="cb27-322"><a href="#cb27-322"></a></span>
+<span id="cb27-323"><a href="#cb27-323"></a>result</span>
+<span id="cb27-324"><a href="#cb27-324"></a><span class="in">```</span></span>
+<span id="cb27-325"><a href="#cb27-325"></a></span>
+<span id="cb27-326"><a href="#cb27-326"></a><span class="fu">## Table with Collapsing &lt;br/&gt; of Grades</span></span>
+<span id="cb27-327"><a href="#cb27-327"></a></span>
+<span id="cb27-328"><a href="#cb27-328"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb27-329"><a href="#cb27-329"></a>grade_groups_1 <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb27-330"><a href="#cb27-330"></a>  <span class="st">"Grade 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb27-331"><a href="#cb27-331"></a>  <span class="st">"Grade 3-5"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>)</span>
+<span id="cb27-332"><a href="#cb27-332"></a>)</span>
+<span id="cb27-333"><a href="#cb27-333"></a></span>
+<span id="cb27-334"><a href="#cb27-334"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-335"><a href="#cb27-335"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-336"><a href="#cb27-336"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-337"><a href="#cb27-337"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-338"><a href="#cb27-338"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-339"><a href="#cb27-339"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-340"><a href="#cb27-340"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-341"><a href="#cb27-341"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-342"><a href="#cb27-342"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-343"><a href="#cb27-343"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-344"><a href="#cb27-344"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-345"><a href="#cb27-345"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-346"><a href="#cb27-346"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-347"><a href="#cb27-347"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-348"><a href="#cb27-348"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-349"><a href="#cb27-349"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-350"><a href="#cb27-350"></a>    <span class="at">grade_groups =</span> grade_groups_1,</span>
+<span id="cb27-351"><a href="#cb27-351"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-352"><a href="#cb27-352"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-353"><a href="#cb27-353"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-354"><a href="#cb27-354"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-355"><a href="#cb27-355"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-356"><a href="#cb27-356"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-357"><a href="#cb27-357"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-358"><a href="#cb27-358"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-359"><a href="#cb27-359"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-360"><a href="#cb27-360"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-361"><a href="#cb27-361"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-362"><a href="#cb27-362"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-363"><a href="#cb27-363"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-364"><a href="#cb27-364"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-365"><a href="#cb27-365"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-366"><a href="#cb27-366"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-367"><a href="#cb27-367"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-368"><a href="#cb27-368"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-369"><a href="#cb27-369"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-370"><a href="#cb27-370"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-371"><a href="#cb27-371"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-372"><a href="#cb27-372"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-373"><a href="#cb27-373"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-374"><a href="#cb27-374"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-375"><a href="#cb27-375"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-376"><a href="#cb27-376"></a>    <span class="at">grade_groups =</span> grade_groups_1,</span>
+<span id="cb27-377"><a href="#cb27-377"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-378"><a href="#cb27-378"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-379"><a href="#cb27-379"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb27-380"><a href="#cb27-380"></a></span>
+<span id="cb27-381"><a href="#cb27-381"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb27-382"><a href="#cb27-382"></a>  <span class="fu">build_table</span>(adae, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-383"><a href="#cb27-383"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb27-384"><a href="#cb27-384"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-385"><a href="#cb27-385"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-386"><a href="#cb27-386"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-387"><a href="#cb27-387"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-388"><a href="#cb27-388"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-389"><a href="#cb27-389"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-390"><a href="#cb27-390"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-391"><a href="#cb27-391"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-392"><a href="#cb27-392"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-393"><a href="#cb27-393"></a>  )</span>
+<span id="cb27-394"><a href="#cb27-394"></a></span>
+<span id="cb27-395"><a href="#cb27-395"></a>result</span>
+<span id="cb27-396"><a href="#cb27-396"></a><span class="in">```</span></span>
+<span id="cb27-397"><a href="#cb27-397"></a></span>
+<span id="cb27-398"><a href="#cb27-398"></a><span class="fu">## Table Using Worst Grade &lt;br/&gt; Flags from ADAE</span></span>
+<span id="cb27-399"><a href="#cb27-399"></a></span>
+<span id="cb27-400"><a href="#cb27-400"></a><span class="in">```{r variant5}</span></span>
+<span id="cb27-401"><a href="#cb27-401"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb27-402"><a href="#cb27-402"></a></span>
+<span id="cb27-403"><a href="#cb27-403"></a><span class="co"># No Worst Grade Flags found in the ADAE data set.</span></span>
+<span id="cb27-404"><a href="#cb27-404"></a><span class="in">```</span></span>
+<span id="cb27-405"><a href="#cb27-405"></a></span>
+<span id="cb27-406"><a href="#cb27-406"></a><span class="fu">## Table with an Incidence Rate &lt;br/&gt; $\geq$ 40%, Totals Restricted</span></span>
+<span id="cb27-407"><a href="#cb27-407"></a></span>
+<span id="cb27-408"><a href="#cb27-408"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb27-409"><a href="#cb27-409"></a><span class="co"># Simple wrapper to return subset ADAE to a threshold of xx%.</span></span>
+<span id="cb27-410"><a href="#cb27-410"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb27-411"><a href="#cb27-411"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb27-412"><a href="#cb27-412"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ACTARM)</span>
+<span id="cb27-413"><a href="#cb27-413"></a></span>
+<span id="cb27-414"><a href="#cb27-414"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb27-415"><a href="#cb27-415"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ACTARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb27-416"><a href="#cb27-416"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb27-417"><a href="#cb27-417"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb27-418"><a href="#cb27-418"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-419"><a href="#cb27-419"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb27-420"><a href="#cb27-420"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb27-421"><a href="#cb27-421"></a></span>
+<span id="cb27-422"><a href="#cb27-422"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb27-423"><a href="#cb27-423"></a>    anl_terms,</span>
+<span id="cb27-424"><a href="#cb27-424"></a>    n_per_arm,</span>
+<span id="cb27-425"><a href="#cb27-425"></a>    <span class="at">by =</span> <span class="st">"ACTARM"</span></span>
+<span id="cb27-426"><a href="#cb27-426"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-427"><a href="#cb27-427"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb27-428"><a href="#cb27-428"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb27-429"><a href="#cb27-429"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-430"><a href="#cb27-430"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb27-431"><a href="#cb27-431"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb27-432"><a href="#cb27-432"></a>    <span class="fu">unique</span>()</span>
+<span id="cb27-433"><a href="#cb27-433"></a></span>
+<span id="cb27-434"><a href="#cb27-434"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb27-435"><a href="#cb27-435"></a>    anl_terms,</span>
+<span id="cb27-436"><a href="#cb27-436"></a>    adae,</span>
+<span id="cb27-437"><a href="#cb27-437"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb27-438"><a href="#cb27-438"></a>  )</span>
+<span id="cb27-439"><a href="#cb27-439"></a>  anl</span>
+<span id="cb27-440"><a href="#cb27-440"></a>}</span>
+<span id="cb27-441"><a href="#cb27-441"></a></span>
+<span id="cb27-442"><a href="#cb27-442"></a>adae6 <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae, <span class="at">cutoff_rate =</span> <span class="fl">0.4</span>)</span>
+<span id="cb27-443"><a href="#cb27-443"></a></span>
+<span id="cb27-444"><a href="#cb27-444"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-445"><a href="#cb27-445"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb27-446"><a href="#cb27-446"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-447"><a href="#cb27-447"></a>    <span class="at">var =</span> <span class="st">"TOTAL_VAR"</span>,</span>
+<span id="cb27-448"><a href="#cb27-448"></a>    <span class="at">label_pos =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb27-449"><a href="#cb27-449"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-450"><a href="#cb27-450"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L</span>
+<span id="cb27-451"><a href="#cb27-451"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-452"><a href="#cb27-452"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-453"><a href="#cb27-453"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-454"><a href="#cb27-454"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-455"><a href="#cb27-455"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-456"><a href="#cb27-456"></a>    <span class="at">.indent_mods =</span> 7L</span>
+<span id="cb27-457"><a href="#cb27-457"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-458"><a href="#cb27-458"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-459"><a href="#cb27-459"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-460"><a href="#cb27-460"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-461"><a href="#cb27-461"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-462"><a href="#cb27-462"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-463"><a href="#cb27-463"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-464"><a href="#cb27-464"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-465"><a href="#cb27-465"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-466"><a href="#cb27-466"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb27-467"><a href="#cb27-467"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb27-468"><a href="#cb27-468"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEBODSYS"</span>]],</span>
+<span id="cb27-469"><a href="#cb27-469"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-470"><a href="#cb27-470"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-471"><a href="#cb27-471"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb27-472"><a href="#cb27-472"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb27-473"><a href="#cb27-473"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb27-474"><a href="#cb27-474"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"- Overall -"</span>, <span class="at">trim =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb27-475"><a href="#cb27-475"></a>    <span class="at">split_label =</span> <span class="fu">var_labels</span>(adae)[[<span class="st">"AEDECOD"</span>]],</span>
+<span id="cb27-476"><a href="#cb27-476"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span></span>
+<span id="cb27-477"><a href="#cb27-477"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-478"><a href="#cb27-478"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb27-479"><a href="#cb27-479"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb27-480"><a href="#cb27-480"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb27-481"><a href="#cb27-481"></a>    <span class="at">.labels =</span> <span class="st">"- Any Grade -"</span>,</span>
+<span id="cb27-482"><a href="#cb27-482"></a>    <span class="at">.indent_mods =</span> 6L</span>
+<span id="cb27-483"><a href="#cb27-483"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-484"><a href="#cb27-484"></a>  <span class="fu">count_occurrences_by_grade</span>(</span>
+<span id="cb27-485"><a href="#cb27-485"></a>    <span class="at">var =</span> <span class="st">"AETOXGR"</span>,</span>
+<span id="cb27-486"><a href="#cb27-486"></a>    <span class="at">grade_groups =</span> grade_groups,</span>
+<span id="cb27-487"><a href="#cb27-487"></a>    <span class="at">.indent_mods =</span> 5L</span>
+<span id="cb27-488"><a href="#cb27-488"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-489"><a href="#cb27-489"></a>  <span class="fu">append_topleft</span>(<span class="st">"                            Grade"</span>)</span>
+<span id="cb27-490"><a href="#cb27-490"></a></span>
+<span id="cb27-491"><a href="#cb27-491"></a>result <span class="ot">&lt;-</span> lyt <span class="sc">%&gt;%</span></span>
+<span id="cb27-492"><a href="#cb27-492"></a>  <span class="fu">build_table</span>(adae6, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb27-493"><a href="#cb27-493"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb27-494"><a href="#cb27-494"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-495"><a href="#cb27-495"></a>    <span class="at">path =</span> <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb27-496"><a href="#cb27-496"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-497"><a href="#cb27-497"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-498"><a href="#cb27-498"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb27-499"><a href="#cb27-499"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb27-500"><a href="#cb27-500"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb27-501"><a href="#cb27-501"></a>    <span class="at">scorefun =</span> score_all_sum,</span>
+<span id="cb27-502"><a href="#cb27-502"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-503"><a href="#cb27-503"></a>  )</span>
+<span id="cb27-504"><a href="#cb27-504"></a></span>
+<span id="cb27-505"><a href="#cb27-505"></a>result</span>
+<span id="cb27-506"><a href="#cb27-506"></a><span class="in">```</span></span>
+<span id="cb27-507"><a href="#cb27-507"></a></span>
+<span id="cb27-508"><a href="#cb27-508"></a><span class="fu">## Table with an Incidence Rate &lt;br/&gt; $\geq$ X%, Totals Unrestricted</span></span>
+<span id="cb27-509"><a href="#cb27-509"></a></span>
+<span id="cb27-510"><a href="#cb27-510"></a><span class="in">```{r variant7}</span></span>
+<span id="cb27-511"><a href="#cb27-511"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb27-512"><a href="#cb27-512"></a></span>
+<span id="cb27-513"><a href="#cb27-513"></a><span class="co"># Variant 7 was not created.</span></span>
+<span id="cb27-514"><a href="#cb27-514"></a><span class="co"># With this variant, the SOC level is not trimmed (even if there are no terms left).</span></span>
+<span id="cb27-515"><a href="#cb27-515"></a><span class="in">```</span></span>
+<span id="cb27-516"><a href="#cb27-516"></a></span>
+<span id="cb27-517"><a href="#cb27-517"></a><span class="fu">## Table with an Incidence &lt;br/&gt; Rate $\geq$ 58 Patients</span></span>
+<span id="cb27-518"><a href="#cb27-518"></a></span>
+<span id="cb27-519"><a href="#cb27-519"></a><span class="in">```{r variant8, test = list(result_v8 = "result")}</span></span>
+<span id="cb27-520"><a href="#cb27-520"></a>cutoff <span class="ot">&lt;-</span> 58L</span>
+<span id="cb27-521"><a href="#cb27-521"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_count_in_any_col</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb27-522"><a href="#cb27-522"></a></span>
+<span id="cb27-523"><a href="#cb27-523"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb27-524"><a href="#cb27-524"></a></span>
+<span id="cb27-525"><a href="#cb27-525"></a>result</span>
+<span id="cb27-526"><a href="#cb27-526"></a><span class="in">```</span></span>
+<span id="cb27-527"><a href="#cb27-527"></a></span>
+<span id="cb27-528"><a href="#cb27-528"></a><span class="fu">## Table with a Difference in &lt;br/&gt; Incidence Rate $\geq$ 10%</span></span>
+<span id="cb27-529"><a href="#cb27-529"></a></span>
+<span id="cb27-530"><a href="#cb27-530"></a><span class="in">```{r variant9, test = list(result_v9 = "result")}</span></span>
+<span id="cb27-531"><a href="#cb27-531"></a>cutoff <span class="ot">&lt;-</span> <span class="fl">0.1</span></span>
+<span id="cb27-532"><a href="#cb27-532"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb27-533"><a href="#cb27-533"></a></span>
+<span id="cb27-534"><a href="#cb27-534"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb27-535"><a href="#cb27-535"></a></span>
+<span id="cb27-536"><a href="#cb27-536"></a>result</span>
+<span id="cb27-537"><a href="#cb27-537"></a><span class="in">```</span></span>
+<span id="cb27-538"><a href="#cb27-538"></a></span>
+<span id="cb27-539"><a href="#cb27-539"></a><span class="fu">## Table with an Incidence Rate &lt;br/&gt; $\geq$ 5%, SOCs \&lt; 5% Removed</span></span>
+<span id="cb27-540"><a href="#cb27-540"></a></span>
+<span id="cb27-541"><a href="#cb27-541"></a><span class="in">```{r variant10}</span></span>
+<span id="cb27-542"><a href="#cb27-542"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb27-543"><a href="#cb27-543"></a></span>
+<span id="cb27-544"><a href="#cb27-544"></a><span class="co"># Variant 10 was not done</span></span>
+<span id="cb27-545"><a href="#cb27-545"></a><span class="co"># With this variant, SOC levels above the threshold are still in the table even if</span></span>
+<span id="cb27-546"><a href="#cb27-546"></a><span class="co"># there are no terms left.</span></span>
+<span id="cb27-547"><a href="#cb27-547"></a><span class="in">```</span></span>
+<span id="cb27-548"><a href="#cb27-548"></a></span>
+<span id="cb27-549"><a href="#cb27-549"></a><span class="fu">## Table with an Incidence Rate $\geq$ 40%, &lt;br/&gt; All SOCs w/o Preferred Terms Removed</span></span>
+<span id="cb27-550"><a href="#cb27-550"></a></span>
+<span id="cb27-551"><a href="#cb27-551"></a><span class="in">```{r variant11, test = list(result_v11 = "result")}</span></span>
+<span id="cb27-552"><a href="#cb27-552"></a>cutoff <span class="ot">&lt;-</span> <span class="fl">0.4</span></span>
+<span id="cb27-553"><a href="#cb27-553"></a>row_condition <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> cutoff, <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ACTARM))</span>
+<span id="cb27-554"><a href="#cb27-554"></a></span>
+<span id="cb27-555"><a href="#cb27-555"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(raw_table, <span class="fu">keep_content_rows</span>(<span class="fu">my_row_condition</span>(row_condition)))</span>
+<span id="cb27-556"><a href="#cb27-556"></a></span>
+<span id="cb27-557"><a href="#cb27-557"></a>result</span>
+<span id="cb27-558"><a href="#cb27-558"></a><span class="in">```</span></span>
+<span id="cb27-559"><a href="#cb27-559"></a></span>
+<span id="cb27-560"><a href="#cb27-560"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb27-561"><a href="#cb27-561"></a></span>
+<span id="cb27-562"><a href="#cb27-562"></a><span class="fu">## `teal` App</span></span>
+<span id="cb27-563"><a href="#cb27-563"></a></span>
+<span id="cb27-564"><a href="#cb27-564"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb27-565"><a href="#cb27-565"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb27-566"><a href="#cb27-566"></a></span>
+<span id="cb27-567"><a href="#cb27-567"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb27-568"><a href="#cb27-568"></a><span class="fu">library</span>(scda)</span>
+<span id="cb27-569"><a href="#cb27-569"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb27-570"><a href="#cb27-570"></a><span class="fu">library</span>(tern)</span>
+<span id="cb27-571"><a href="#cb27-571"></a></span>
+<span id="cb27-572"><a href="#cb27-572"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb27-573"><a href="#cb27-573"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb27-574"><a href="#cb27-574"></a></span>
+<span id="cb27-575"><a href="#cb27-575"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb27-576"><a href="#cb27-576"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb27-577"><a href="#cb27-577"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb27-578"><a href="#cb27-578"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb27-579"><a href="#cb27-579"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb27-580"><a href="#cb27-580"></a><span class="st">    ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb27-581"><a href="#cb27-581"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb27-582"><a href="#cb27-582"></a>  ),</span>
+<span id="cb27-583"><a href="#cb27-583"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb27-584"><a href="#cb27-584"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb27-585"><a href="#cb27-585"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb27-586"><a href="#cb27-586"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb27-587"><a href="#cb27-587"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb27-588"><a href="#cb27-588"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb27-589"><a href="#cb27-589"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb27-590"><a href="#cb27-590"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb27-591"><a href="#cb27-591"></a>      ),</span>
+<span id="cb27-592"><a href="#cb27-592"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb27-593"><a href="#cb27-593"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb27-594"><a href="#cb27-594"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb27-595"><a href="#cb27-595"></a>      ),</span>
+<span id="cb27-596"><a href="#cb27-596"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb27-597"><a href="#cb27-597"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb27-598"><a href="#cb27-598"></a>        <span class="at">selected =</span> <span class="st">"AETOXGR"</span></span>
+<span id="cb27-599"><a href="#cb27-599"></a>      )</span>
+<span id="cb27-600"><a href="#cb27-600"></a>    )</span>
+<span id="cb27-601"><a href="#cb27-601"></a>  )</span>
+<span id="cb27-602"><a href="#cb27-602"></a>)</span>
+<span id="cb27-603"><a href="#cb27-603"></a></span>
+<span id="cb27-604"><a href="#cb27-604"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb27-605"><a href="#cb27-605"></a><span class="in">```</span></span>
+<span id="cb27-606"><a href="#cb27-606"></a></span>
+<span id="cb27-607"><a href="#cb27-607"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb27-608"><a href="#cb27-608"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
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+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
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diff --git a/stable/tables/adverse-events/aet04_pi.html b/stable/tables/adverse-events/aet04_pi.html
new file mode 100644
index 0000000000..d76f67850b
--- /dev/null
+++ b/stable/tables/adverse-events/aet04_pi.html
@@ -0,0 +1,2897 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET04_PI</title>
+<style>
+code{white-space: pre-wrap;}
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+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET04_PI</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events Reported in <span class="math inline">\(\geq\)</span> 10% of Patients by Highest NCI CTCAE Grade</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Patients Treated with a Particular Treatment by Highest NCI <br> CTCAE Grade (specifying a treatment for selecting preferred terms)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Adverse Events Reported in <span class="math inline">\(\geq\)</span> 5% of Patients by <br> Highest NCI CTCAE Grade (changing the threshold)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Adverse Events Reported in <span class="math inline">\(\geq\)</span> 5% of Patients and <br><span class="math inline">\(\geq\)</span> 2% Difference Between Treatments by Highest <br> NCI CTCAE Grade (using more than one condition)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Adverse Events Reported in <span class="math inline">\(\geq\)</span> 10% of Patients for Any Grade <br> or <span class="math inline">\(\geq\)</span> 5% of Patients for Grade 3-4 by Highest NCI CTCAE <br> Grade (using different condition depending on the grade)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Standard Table with <br> Modified Grade Grouping</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Standard Table with <br> Overlapping Grade Groupings</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Standard Table without SOCs</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-10-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-10" role="tab" aria-controls="tabset-1-10" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-11-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-11" role="tab" aria-controls="tabset-1-11" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet04_pi_cache/html/setup_e341fb173848514f0dd39bc4ff210f33">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>preprocess_adae <span class="ot">&lt;-</span> <span class="cf">function</span>(adae) {</span>
+<span id="cb1-6"><a href="#cb1-6"></a>  adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ACTARM, USUBJID, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>    dplyr<span class="sc">::</span><span class="fu">summarize</span>(</span>
+<span id="cb1-9"><a href="#cb1-9"></a>      <span class="at">MAXAETOXGR =</span> <span class="fu">max</span>(<span class="fu">as.numeric</span>(AETOXGR)),</span>
+<span id="cb1-10"><a href="#cb1-10"></a>      <span class="at">.groups =</span> <span class="st">"drop"</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>      <span class="at">MAXAETOXGR =</span> <span class="fu">factor</span>(MAXAETOXGR),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      <span class="at">AEDECOD =</span> <span class="fu">droplevels</span>(<span class="fu">as.factor</span>(AEDECOD))</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    )</span>
+<span id="cb1-17"><a href="#cb1-17"></a>}</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>full_table_aet04_pi <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae_max) {</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  )</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="fu">analyze_vars</span>(</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      <span class="st">"AEDECOD"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>      <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>      <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>      <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts)</span>
+<span id="cb1-49"><a href="#cb1-49"></a>}</span>
+<span id="cb1-50"><a href="#cb1-50"></a></span>
+<span id="cb1-51"><a href="#cb1-51"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb1-53"><a href="#cb1-53"></a>}</span>
+<span id="cb1-54"><a href="#cb1-54"></a></span>
+<span id="cb1-55"><a href="#cb1-55"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-56"><a href="#cb1-56"></a>adae_max <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">preprocess_adae</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-58"><a href="#cb1-58"></a>  <span class="fu">df_explicit_na</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant1_77c6598b55fad84d63a47404749c5064">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  )</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>at_least_10percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.1</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_10percent_any))</span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                             
+dcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     
+dcd A.1.1.1.2                    36               0              0             36               0              0             38               0              0     
+cl B.2                                                                                                                                                             
+dcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     
+dcd B.2.1.2.1                    37              37              0             33              33              0             39              39              0     
+cl D.1                                                                                                                                                             
+dcd D.1.1.1.1                    37               0             37             31               0             31             39               0             39     
+dcd D.1.1.4.2                    36              36              0             31              31              0             38              38              0     
+cl D.2                                                                                                                                                             
+dcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     
+cl B.1                                                                                                                                                             
+dcd B.1.1.1.1                    35               0             35             37               0             37             33               0             33     
+cl C.2                                                                                                                                                             
+dcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     
+cl C.1                                                                                                                                                             
+dcd C.1.1.1.3                    32              32              0             34              34              0             33              33              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example uses the “Any Grade” column for treatment A: Drug X with a filtering threshold at 0.37; AEs reported in greater than 37% of patients in treatment A: Drug X are shown. This can be changed by varying the parameter values in the <code>has_fraction_in_cols</code> function.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant2_b06af40cc9d92d3a20718eeaed9533cc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  )</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>at_least_37percent_any_drugx <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_cols</span>(<span class="at">atleast =</span> <span class="fl">0.37</span>, <span class="at">col_indices =</span> <span class="dv">1</span>)</span>
+<span id="cb4-14"><a href="#cb4-14"></a></span>
+<span id="cb4-15"><a href="#cb4-15"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_37percent_any_drugx))</span>
+<span id="cb4-18"><a href="#cb4-18"></a></span>
+<span id="cb4-19"><a href="#cb4-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                             
+dcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     
+cl D.1                                                                                                                                                             
+dcd D.1.1.1.1                    37               0             37             31               0             31             39               0             39     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.40 to demonstrate the filtering ability; AEs reported in greater than 40% of patients are shown. This can be changed by varying the parameter values in the <code>has_fraction_in_any_col</code> function.</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant3_cf3be05983c917e11a0921686f1176e3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-3"><a href="#cb6-3"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  )</span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.40</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb6-14"><a href="#cb6-14"></a></span>
+<span id="cb6-15"><a href="#cb6-15"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb6-18"><a href="#cb6-18"></a></span>
+<span id="cb6-19"><a href="#cb6-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                             
+dcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     
+cl B.2                                                                                                                                                             
+dcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     
+cl D.2                                                                                                                                                             
+dcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     
+cl C.2                                                                                                                                                             
+dcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 to filter for AEs reported in <span class="math inline">\(\geq\)</span> 30% of patients and AEs reported with a <span class="math inline">\(\geq\)</span> 15% difference between treatments to demonstrate the filtering ability; this can be changed by varying the parameter values in the <code>has_fraction_in_any_col</code> and <code>has_fractions_difference</code> functions.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant4_4cf3cf38d71186ebf75498fd43c0de6b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-3"><a href="#cb8-3"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>  )</span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>at_least_30percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.3</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a>at_least_15percent_diff <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.15</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb8-16"><a href="#cb8-16"></a></span>
+<span id="cb8-17"><a href="#cb8-17"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb8-19"><a href="#cb8-19"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_30percent_any <span class="sc">&amp;</span> at_least_15percent_diff))</span>
+<span id="cb8-20"><a href="#cb8-20"></a></span>
+<span id="cb8-21"><a href="#cb8-21"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl C.2                                                                                                                                                             
+dcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example filters using column indices 1, 4, and 7 to include AEs reported in <span class="math inline">\(\geq\)</span> 40% of patients and using column indices 2, 5, and 8 to include grade 3-4 AEs reported in <span class="math inline">\(\geq\)</span> 20% of patients. These thresholds are chosen to demonstrate the filtering ability; they can be changed by varying parameter values in the <code>has_fraction_in_any_col</code> function.</p>
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant5_52a1d9d1382f32cc7a69cbb79d90bb64">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-3"><a href="#cb10-3"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb10-4"><a href="#cb10-4"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb10-5"><a href="#cb10-5"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-6"><a href="#cb10-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-8"><a href="#cb10-8"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb10-9"><a href="#cb10-9"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a>  )</span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb10-14"><a href="#cb10-14"></a></span>
+<span id="cb10-15"><a href="#cb10-15"></a>at_least_20percent_g34 <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.20</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">2</span>, <span class="dv">5</span>, <span class="dv">8</span>))</span>
+<span id="cb10-16"><a href="#cb10-16"></a></span>
+<span id="cb10-17"><a href="#cb10-17"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb10-19"><a href="#cb10-19"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any <span class="sc">|</span> at_least_20percent_g34))</span>
+<span id="cb10-20"><a href="#cb10-20"></a></span>
+<span id="cb10-21"><a href="#cb10-21"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                    A: Drug X                                    B: Placebo                                  C: Combination               
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                             
+dcd A.1.1.1.1                    37               0              0             34               0              0             48               0              0     
+cl B.2                                                                                                                                                             
+dcd B.2.2.3.1                    36               0              0             40               0              0             39               0              0     
+dcd B.2.1.2.1                    37              37              0             33              33              0             39              39              0     
+cl D.1                                                                                                                                                             
+dcd D.1.1.4.2                    36              36              0             31              31              0             38              38              0     
+cl D.2                                                                                                                                                             
+dcd D.2.1.5.3                    35               0              0             43               0              0             43               0              0     
+cl C.2                                                                                                                                                             
+dcd C.2.1.2.1                    26               0              0             36               0              0             42               0              0     
+cl C.1                                                                                                                                                             
+dcd C.1.1.1.3                    32              32              0             34              34              0             33              33              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<p>Note: User can specify/modify the grouping of grades, as shown in this example. In addition, the user needs to specify the column index for filtering the table. The current example uses the “Any Grade” columns with a filtering threshold at 0.40; this can be changed by varying the parameter values in the <code>has_fraction_in_any_col</code> function.</p>
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant6_d6514b2f2e2e37220764dde6dc52a3cb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb12-2"><a href="#cb12-2"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb12-3"><a href="#cb12-3"></a>  <span class="st">"Grade 1-2 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb12-4"><a href="#cb12-4"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb12-5"><a href="#cb12-5"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb12-6"><a href="#cb12-6"></a>)</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-11"><a href="#cb12-11"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb12-13"><a href="#cb12-13"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb12-15"><a href="#cb12-15"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-16"><a href="#cb12-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-18"><a href="#cb12-18"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-19"><a href="#cb12-19"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-20"><a href="#cb12-20"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb12-21"><a href="#cb12-21"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb12-22"><a href="#cb12-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-23"><a href="#cb12-23"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb12-24"><a href="#cb12-24"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-25"><a href="#cb12-25"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-26"><a href="#cb12-26"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb12-27"><a href="#cb12-27"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb12-28"><a href="#cb12-28"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb12-29"><a href="#cb12-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts) <span class="sc">%&gt;%</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb12-35"><a href="#cb12-35"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-38"><a href="#cb12-38"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb12-40"><a href="#cb12-40"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>  )</span>
+<span id="cb12-42"><a href="#cb12-42"></a></span>
+<span id="cb12-43"><a href="#cb12-43"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>))</span>
+<span id="cb12-44"><a href="#cb12-44"></a></span>
+<span id="cb12-45"><a href="#cb12-45"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb12-48"><a href="#cb12-48"></a></span>
+<span id="cb12-49"><a href="#cb12-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                            A: Drug X                                                    B: Placebo                                                  C: Combination                       
+  MedDRA Preferred Term     Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 1-2 (%)   Grade 3-4 (%)   Grade 5 (%)
+                               (N=134)         (N=134)         (N=134)        (N=134)        (N=134)         (N=134)         (N=134)        (N=134)        (N=132)         (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                                                                             
+dcd A.1.1.1.1                    37              37               0              0             34              34               0              0             48              48               0              0     
+cl B.2                                                                                                                                                                                                             
+dcd B.2.2.3.1                    36              36               0              0             40              40               0              0             39              39               0              0     
+cl D.2                                                                                                                                                                                                             
+dcd D.2.1.5.3                    35              35               0              0             43              43               0              0             43              43               0              0     
+cl C.2                                                                                                                                                                                                             
+dcd C.2.1.2.1                    26              26               0              0             36              36               0              0             42              42               0              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example uses column indices 1, 5, and 9 with a filtering threshold at 0.40 to demonstrate the filtering ability; any grade AEs reported in greater than 40% of patients are shown. This can be changed by varying the parameter values in the <code>has_fraction_in_any_col</code> function.</p>
+<div class="cell" data-test="{&quot;result_v7&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant7_231e8050c0c753dac17eca98483d7272">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb14-2"><a href="#cb14-2"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb14-3"><a href="#cb14-3"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb14-4"><a href="#cb14-4"></a>  <span class="st">"Grade 3-5 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb14-5"><a href="#cb14-5"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb14-6"><a href="#cb14-6"></a>)</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb14-9"><a href="#cb14-9"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-10"><a href="#cb14-10"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-11"><a href="#cb14-11"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb14-13"><a href="#cb14-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb14-14"><a href="#cb14-14"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb14-15"><a href="#cb14-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-16"><a href="#cb14-16"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-17"><a href="#cb14-17"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb14-18"><a href="#cb14-18"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-19"><a href="#cb14-19"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb14-20"><a href="#cb14-20"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb14-21"><a href="#cb14-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-22"><a href="#cb14-22"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-23"><a href="#cb14-23"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb14-24"><a href="#cb14-24"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-25"><a href="#cb14-25"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb14-26"><a href="#cb14-26"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-27"><a href="#cb14-27"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb14-28"><a href="#cb14-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-29"><a href="#cb14-29"></a>  <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts) <span class="sc">%&gt;%</span></span>
+<span id="cb14-31"><a href="#cb14-31"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb14-32"><a href="#cb14-32"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb14-33"><a href="#cb14-33"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb14-34"><a href="#cb14-34"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-35"><a href="#cb14-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-36"><a href="#cb14-36"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb14-37"><a href="#cb14-37"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb14-38"><a href="#cb14-38"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb14-39"><a href="#cb14-39"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>  )</span>
+<span id="cb14-41"><a href="#cb14-41"></a></span>
+<span id="cb14-42"><a href="#cb14-42"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>))</span>
+<span id="cb14-43"><a href="#cb14-43"></a></span>
+<span id="cb14-44"><a href="#cb14-44"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb14-45"><a href="#cb14-45"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb14-46"><a href="#cb14-46"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb14-47"><a href="#cb14-47"></a></span>
+<span id="cb14-48"><a href="#cb14-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                            A: Drug X                                                    B: Placebo                                                  C: Combination                       
+  MedDRA Preferred Term     Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 3-5 (%)   Grade 5 (%)
+                               (N=134)         (N=134)         (N=134)        (N=134)        (N=134)         (N=134)         (N=134)        (N=134)        (N=132)         (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+cl A.1                                                                                                                                                                                                             
+dcd A.1.1.1.1                    37               0               0              0             34               0               0              0             48               0               0              0     
+cl B.2                                                                                                                                                                                                             
+dcd B.2.2.3.1                    36               0               0              0             40               0               0              0             39               0               0              0     
+cl D.2                                                                                                                                                                                                             
+dcd D.2.1.5.3                    35               0               0              0             43               0               0              0             43               0               0              0     
+cl C.2                                                                                                                                                                                                             
+dcd C.2.1.2.1                    26               0               0              0             36               0               0              0             42               0               0              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<p>Note: User needs to specify the column index for filtering the table. The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.20 to demonstrate the filtering ability; any grade AEs (Preferred Terms Only) reported in greater than 20% of patients are shown. This can be changed by varying the parameter values in the <code>has_fraction_in_any_col</code> function.</p>
+<div class="cell" data-test="{&quot;result_v8&quot;:&quot;result&quot;}" data-hash="aet04_pi_cache/html/variant8_045209a629ea6c734597ce3c43015949">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-2"><a href="#cb16-2"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb16-3"><a href="#cb16-3"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb16-4"><a href="#cb16-4"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a>)</span>
+<span id="cb16-6"><a href="#cb16-6"></a></span>
+<span id="cb16-7"><a href="#cb16-7"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb16-8"><a href="#cb16-8"></a></span>
+<span id="cb16-9"><a href="#cb16-9"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-10"><a href="#cb16-10"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-11"><a href="#cb16-11"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-13"><a href="#cb16-13"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb16-14"><a href="#cb16-14"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-15"><a href="#cb16-15"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb16-16"><a href="#cb16-16"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-17"><a href="#cb16-17"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb16-18"><a href="#cb16-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-19"><a href="#cb16-19"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-20"><a href="#cb16-20"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts)</span>
+<span id="cb16-21"><a href="#cb16-21"></a></span>
+<span id="cb16-22"><a href="#cb16-22"></a>at_least_20percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.2</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb16-23"><a href="#cb16-23"></a></span>
+<span id="cb16-24"><a href="#cb16-24"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb16-25"><a href="#cb16-25"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_20percent_any)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-26"><a href="#cb16-26"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-27"><a href="#cb16-27"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb16-28"><a href="#cb16-28"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb16-29"><a href="#cb16-29"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-30"><a href="#cb16-30"></a>  )</span>
+<span id="cb16-31"><a href="#cb16-31"></a></span>
+<span id="cb16-32"><a href="#cb16-32"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA Preferred Term                    A: Drug X                                    B: Placebo                                  C: Combination               
+                        Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)   Any Grade (%)   Grade 3-4 (%)   Grade 5 (%)
+                           (N=134)         (N=134)        (N=134)        (N=134)         (N=134)        (N=134)        (N=132)         (N=132)        (N=132)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+dcd D.2.1.5.3                35               0              0             43               0              0             43               0              0     
+dcd A.1.1.1.1                37               0              0             34               0              0             48               0              0     
+dcd B.2.2.3.1                36               0              0             40               0              0             39               0              0     
+dcd A.1.1.1.2                36               0              0             36               0              0             38               0              0     
+dcd B.2.1.2.1                37              37              0             33              33              0             39              39              0     
+dcd D.1.1.1.1                37               0             37             31               0             31             39               0             39     
+dcd D.1.1.4.2                36              36              0             31              31              0             38              38              0     
+dcd B.1.1.1.1                35               0             35             37               0             37             33               0             33     
+dcd C.2.1.2.1                26               0              0             36               0              0             42               0              0     
+dcd C.1.1.1.3                32              32              0             34              34              0             33              33              0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-10" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-10-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet04_pi_cache/html/teal_80020f8f606e89b2772201b5bb59f3b6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="fu">library</span>(tern)</span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-7"><a href="#cb18-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb18-8"><a href="#cb18-8"></a></span>
+<span id="cb18-9"><a href="#cb18-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb18-10"><a href="#cb18-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb18-11"><a href="#cb18-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb18-12"><a href="#cb18-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb18-13"><a href="#cb18-13"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb18-14"><a href="#cb18-14"></a><span class="st">    ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb18-15"><a href="#cb18-15"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-16"><a href="#cb18-16"></a>  ),</span>
+<span id="cb18-17"><a href="#cb18-17"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb18-18"><a href="#cb18-18"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb18-19"><a href="#cb18-19"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb18-20"><a href="#cb18-20"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb18-21"><a href="#cb18-21"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb18-22"><a href="#cb18-22"></a>      <span class="at">col_by_grade =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-23"><a href="#cb18-23"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-24"><a href="#cb18-24"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb18-25"><a href="#cb18-25"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb18-26"><a href="#cb18-26"></a>      ),</span>
+<span id="cb18-27"><a href="#cb18-27"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-28"><a href="#cb18-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb18-29"><a href="#cb18-29"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb18-30"><a href="#cb18-30"></a>      ),</span>
+<span id="cb18-31"><a href="#cb18-31"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-32"><a href="#cb18-32"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb18-33"><a href="#cb18-33"></a>        <span class="at">selected =</span> <span class="st">"AETOXGR"</span></span>
+<span id="cb18-34"><a href="#cb18-34"></a>      ),</span>
+<span id="cb18-35"><a href="#cb18-35"></a>      <span class="co"># List of column groups for grades used when `col_by_grade` = TRUE.</span></span>
+<span id="cb18-36"><a href="#cb18-36"></a>      <span class="at">grading_groups =</span> <span class="fu">list</span>(</span>
+<span id="cb18-37"><a href="#cb18-37"></a>        <span class="st">`</span><span class="at">Any Grade (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb18-38"><a href="#cb18-38"></a>        <span class="st">`</span><span class="at">Grade 3-4 (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb18-39"><a href="#cb18-39"></a>        <span class="st">`</span><span class="at">Grade 5 (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb18-40"><a href="#cb18-40"></a>      )</span>
+<span id="cb18-41"><a href="#cb18-41"></a>    )</span>
+<span id="cb18-42"><a href="#cb18-42"></a>  )</span>
+<span id="cb18-43"><a href="#cb18-43"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:23:03.0411 pid:11390 token:[] teal.modules.clinical Initializing tm_t_events_by_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb20"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb20-1"><a href="#cb20-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet04_pi_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-11" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-11-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet04_pi_cache/html/sessioninfo_65f4b1fb060a6f137d0faa39be8703f3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb21"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb21-1"><a href="#cb21-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet04_pi_cache/html/snapshot_b814f6b910b4b1b66238a21d53731a0b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb23"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb23-1"><a href="#cb23-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb23-2"><a href="#cb23-2"></a></span>
+<span id="cb23-3"><a href="#cb23-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb23-4"><a href="#cb23-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb23-5"><a href="#cb23-5"></a></span>
+<span id="cb23-6"><a href="#cb23-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb23-7"><a href="#cb23-7"></a></span>
+<span id="cb23-8"><a href="#cb23-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb23-9"><a href="#cb23-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb23-10"><a href="#cb23-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb23-11"><a href="#cb23-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet04_pi.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../tables/adverse-events/aet04.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET04</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet05.html" class="pagination-link">
+        <span class="nav-page-text">AET05</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb24" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb24-1"><a href="#cb24-1"></a><span class="co">---</span></span>
+<span id="cb24-2"><a href="#cb24-2"></a><span class="an">title:</span><span class="co"> AET04_PI</span></span>
+<span id="cb24-3"><a href="#cb24-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events Reported in $\geq$ 10% of Patients by Highest NCI CTCAE Grade</span></span>
+<span id="cb24-4"><a href="#cb24-4"></a><span class="co">---</span></span>
+<span id="cb24-5"><a href="#cb24-5"></a></span>
+<span id="cb24-6"><a href="#cb24-6"></a>------------------------------------------------------------------------</span>
+<span id="cb24-7"><a href="#cb24-7"></a></span>
+<span id="cb24-8"><a href="#cb24-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb24-9"><a href="#cb24-9"></a></span>
+<span id="cb24-10"><a href="#cb24-10"></a>::: panel-tabset</span>
+<span id="cb24-11"><a href="#cb24-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb24-12"><a href="#cb24-12"></a></span>
+<span id="cb24-13"><a href="#cb24-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb24-14"><a href="#cb24-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb24-15"><a href="#cb24-15"></a></span>
+<span id="cb24-16"><a href="#cb24-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb24-17"><a href="#cb24-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb24-18"><a href="#cb24-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb24-19"><a href="#cb24-19"></a></span>
+<span id="cb24-20"><a href="#cb24-20"></a>preprocess_adae <span class="ot">&lt;-</span> <span class="cf">function</span>(adae) {</span>
+<span id="cb24-21"><a href="#cb24-21"></a>  adae <span class="sc">%&gt;%</span></span>
+<span id="cb24-22"><a href="#cb24-22"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ACTARM, USUBJID, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb24-23"><a href="#cb24-23"></a>    dplyr<span class="sc">::</span><span class="fu">summarize</span>(</span>
+<span id="cb24-24"><a href="#cb24-24"></a>      <span class="at">MAXAETOXGR =</span> <span class="fu">max</span>(<span class="fu">as.numeric</span>(AETOXGR)),</span>
+<span id="cb24-25"><a href="#cb24-25"></a>      <span class="at">.groups =</span> <span class="st">"drop"</span></span>
+<span id="cb24-26"><a href="#cb24-26"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-27"><a href="#cb24-27"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-28"><a href="#cb24-28"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb24-29"><a href="#cb24-29"></a>      <span class="at">MAXAETOXGR =</span> <span class="fu">factor</span>(MAXAETOXGR),</span>
+<span id="cb24-30"><a href="#cb24-30"></a>      <span class="at">AEDECOD =</span> <span class="fu">droplevels</span>(<span class="fu">as.factor</span>(AEDECOD))</span>
+<span id="cb24-31"><a href="#cb24-31"></a>    )</span>
+<span id="cb24-32"><a href="#cb24-32"></a>}</span>
+<span id="cb24-33"><a href="#cb24-33"></a></span>
+<span id="cb24-34"><a href="#cb24-34"></a>full_table_aet04_pi <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae_max) {</span>
+<span id="cb24-35"><a href="#cb24-35"></a>  grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb24-36"><a href="#cb24-36"></a>    <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-37"><a href="#cb24-37"></a>    <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb24-38"><a href="#cb24-38"></a>    <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb24-39"><a href="#cb24-39"></a>  )</span>
+<span id="cb24-40"><a href="#cb24-40"></a></span>
+<span id="cb24-41"><a href="#cb24-41"></a>  col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb24-42"><a href="#cb24-42"></a>  <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-43"><a href="#cb24-43"></a>    <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-44"><a href="#cb24-44"></a>    <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb24-45"><a href="#cb24-45"></a>    <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb24-46"><a href="#cb24-46"></a>      <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb24-47"><a href="#cb24-47"></a>      <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb24-48"><a href="#cb24-48"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-49"><a href="#cb24-49"></a>    <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-50"><a href="#cb24-50"></a>    <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb24-51"><a href="#cb24-51"></a>      <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb24-52"><a href="#cb24-52"></a>      <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb24-53"><a href="#cb24-53"></a>      <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb24-54"><a href="#cb24-54"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-55"><a href="#cb24-55"></a>    <span class="fu">analyze_vars</span>(</span>
+<span id="cb24-56"><a href="#cb24-56"></a>      <span class="st">"AEDECOD"</span>,</span>
+<span id="cb24-57"><a href="#cb24-57"></a>      <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb24-58"><a href="#cb24-58"></a>      <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb24-59"><a href="#cb24-59"></a>      <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb24-60"><a href="#cb24-60"></a>      <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb24-61"><a href="#cb24-61"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-62"><a href="#cb24-62"></a>    <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-63"><a href="#cb24-63"></a>    <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts)</span>
+<span id="cb24-64"><a href="#cb24-64"></a>}</span>
+<span id="cb24-65"><a href="#cb24-65"></a></span>
+<span id="cb24-66"><a href="#cb24-66"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb24-67"><a href="#cb24-67"></a>  <span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>)</span>
+<span id="cb24-68"><a href="#cb24-68"></a>}</span>
+<span id="cb24-69"><a href="#cb24-69"></a></span>
+<span id="cb24-70"><a href="#cb24-70"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb24-71"><a href="#cb24-71"></a>adae_max <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-72"><a href="#cb24-72"></a>  <span class="fu">preprocess_adae</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-73"><a href="#cb24-73"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb24-74"><a href="#cb24-74"></a><span class="in">```</span></span>
+<span id="cb24-75"><a href="#cb24-75"></a></span>
+<span id="cb24-76"><a href="#cb24-76"></a><span class="fu">## Standard Table</span></span>
+<span id="cb24-77"><a href="#cb24-77"></a></span>
+<span id="cb24-78"><a href="#cb24-78"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb24-79"><a href="#cb24-79"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb24-80"><a href="#cb24-80"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-81"><a href="#cb24-81"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-82"><a href="#cb24-82"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-83"><a href="#cb24-83"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-84"><a href="#cb24-84"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-85"><a href="#cb24-85"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-86"><a href="#cb24-86"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-87"><a href="#cb24-87"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-88"><a href="#cb24-88"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-89"><a href="#cb24-89"></a>  )</span>
+<span id="cb24-90"><a href="#cb24-90"></a></span>
+<span id="cb24-91"><a href="#cb24-91"></a>at_least_10percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.1</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-92"><a href="#cb24-92"></a></span>
+<span id="cb24-93"><a href="#cb24-93"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-94"><a href="#cb24-94"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-95"><a href="#cb24-95"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_10percent_any))</span>
+<span id="cb24-96"><a href="#cb24-96"></a></span>
+<span id="cb24-97"><a href="#cb24-97"></a>result</span>
+<span id="cb24-98"><a href="#cb24-98"></a><span class="in">```</span></span>
+<span id="cb24-99"><a href="#cb24-99"></a></span>
+<span id="cb24-100"><a href="#cb24-100"></a><span class="fu">## Table with Patients Treated with a Particular Treatment by Highest NCI &lt;br/&gt; CTCAE Grade (specifying a treatment for selecting preferred terms)</span></span>
+<span id="cb24-101"><a href="#cb24-101"></a></span>
+<span id="cb24-102"><a href="#cb24-102"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-103"><a href="#cb24-103"></a>The current example uses the "Any Grade" column for treatment A: Drug X with a filtering threshold at 0.37; AEs reported in greater than 37% of patients in treatment A: Drug X are shown.</span>
+<span id="cb24-104"><a href="#cb24-104"></a>This can be changed by varying the parameter values in the <span class="in">`has_fraction_in_cols`</span> function.</span>
+<span id="cb24-105"><a href="#cb24-105"></a></span>
+<span id="cb24-106"><a href="#cb24-106"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb24-107"><a href="#cb24-107"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb24-108"><a href="#cb24-108"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-109"><a href="#cb24-109"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-110"><a href="#cb24-110"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-111"><a href="#cb24-111"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-112"><a href="#cb24-112"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-113"><a href="#cb24-113"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-114"><a href="#cb24-114"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-115"><a href="#cb24-115"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-116"><a href="#cb24-116"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-117"><a href="#cb24-117"></a>  )</span>
+<span id="cb24-118"><a href="#cb24-118"></a></span>
+<span id="cb24-119"><a href="#cb24-119"></a>at_least_37percent_any_drugx <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_cols</span>(<span class="at">atleast =</span> <span class="fl">0.37</span>, <span class="at">col_indices =</span> <span class="dv">1</span>)</span>
+<span id="cb24-120"><a href="#cb24-120"></a></span>
+<span id="cb24-121"><a href="#cb24-121"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-122"><a href="#cb24-122"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-123"><a href="#cb24-123"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_37percent_any_drugx))</span>
+<span id="cb24-124"><a href="#cb24-124"></a></span>
+<span id="cb24-125"><a href="#cb24-125"></a>result</span>
+<span id="cb24-126"><a href="#cb24-126"></a><span class="in">```</span></span>
+<span id="cb24-127"><a href="#cb24-127"></a></span>
+<span id="cb24-128"><a href="#cb24-128"></a><span class="fu">## Adverse Events Reported in $\geq$ 5% of Patients by &lt;br/&gt; Highest NCI CTCAE Grade (changing the threshold)</span></span>
+<span id="cb24-129"><a href="#cb24-129"></a></span>
+<span id="cb24-130"><a href="#cb24-130"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-131"><a href="#cb24-131"></a>The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.40 to demonstrate the filtering ability; AEs reported in greater than 40% of patients are shown.</span>
+<span id="cb24-132"><a href="#cb24-132"></a>This can be changed by varying the parameter values in the <span class="in">`has_fraction_in_any_col`</span> function.</span>
+<span id="cb24-133"><a href="#cb24-133"></a></span>
+<span id="cb24-134"><a href="#cb24-134"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb24-135"><a href="#cb24-135"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb24-136"><a href="#cb24-136"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-137"><a href="#cb24-137"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-138"><a href="#cb24-138"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-139"><a href="#cb24-139"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-140"><a href="#cb24-140"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-141"><a href="#cb24-141"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-142"><a href="#cb24-142"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-143"><a href="#cb24-143"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-144"><a href="#cb24-144"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-145"><a href="#cb24-145"></a>  )</span>
+<span id="cb24-146"><a href="#cb24-146"></a></span>
+<span id="cb24-147"><a href="#cb24-147"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.40</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-148"><a href="#cb24-148"></a></span>
+<span id="cb24-149"><a href="#cb24-149"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-150"><a href="#cb24-150"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-151"><a href="#cb24-151"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb24-152"><a href="#cb24-152"></a></span>
+<span id="cb24-153"><a href="#cb24-153"></a>result</span>
+<span id="cb24-154"><a href="#cb24-154"></a><span class="in">```</span></span>
+<span id="cb24-155"><a href="#cb24-155"></a></span>
+<span id="cb24-156"><a href="#cb24-156"></a><span class="fu">## Adverse Events Reported in $\geq$ 5% of Patients and &lt;br/&gt; $\geq$ 2% Difference Between Treatments by Highest &lt;br/&gt; NCI CTCAE Grade (using more than one condition)</span></span>
+<span id="cb24-157"><a href="#cb24-157"></a></span>
+<span id="cb24-158"><a href="#cb24-158"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-159"><a href="#cb24-159"></a>The current example uses column indices 1, 4, and 7 to filter for AEs reported in $\geq$ 30% of patients and AEs reported with a $\geq$ 15% difference between treatments to demonstrate the filtering ability; this can be changed by varying the parameter values in the <span class="in">`has_fraction_in_any_col`</span> and <span class="in">`has_fractions_difference`</span> functions.</span>
+<span id="cb24-160"><a href="#cb24-160"></a></span>
+<span id="cb24-161"><a href="#cb24-161"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb24-162"><a href="#cb24-162"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb24-163"><a href="#cb24-163"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-164"><a href="#cb24-164"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-165"><a href="#cb24-165"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-166"><a href="#cb24-166"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-167"><a href="#cb24-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-168"><a href="#cb24-168"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-169"><a href="#cb24-169"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-170"><a href="#cb24-170"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-171"><a href="#cb24-171"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-172"><a href="#cb24-172"></a>  )</span>
+<span id="cb24-173"><a href="#cb24-173"></a></span>
+<span id="cb24-174"><a href="#cb24-174"></a>at_least_30percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.3</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-175"><a href="#cb24-175"></a></span>
+<span id="cb24-176"><a href="#cb24-176"></a>at_least_15percent_diff <span class="ot">&lt;-</span> <span class="fu">has_fractions_difference</span>(<span class="at">atleast =</span> <span class="fl">0.15</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-177"><a href="#cb24-177"></a></span>
+<span id="cb24-178"><a href="#cb24-178"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-179"><a href="#cb24-179"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-180"><a href="#cb24-180"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_30percent_any <span class="sc">&amp;</span> at_least_15percent_diff))</span>
+<span id="cb24-181"><a href="#cb24-181"></a></span>
+<span id="cb24-182"><a href="#cb24-182"></a>result</span>
+<span id="cb24-183"><a href="#cb24-183"></a><span class="in">```</span></span>
+<span id="cb24-184"><a href="#cb24-184"></a></span>
+<span id="cb24-185"><a href="#cb24-185"></a><span class="fu">## Adverse Events Reported in $\geq$ 10% of Patients for Any Grade &lt;br/&gt; or $\geq$ 5% of Patients for Grade 3-4 by Highest NCI CTCAE &lt;br/&gt; Grade (using different condition depending on the grade)</span></span>
+<span id="cb24-186"><a href="#cb24-186"></a></span>
+<span id="cb24-187"><a href="#cb24-187"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-188"><a href="#cb24-188"></a>The current example filters using column indices 1, 4, and 7 to include AEs reported in $\geq$ 40% of patients and using column indices 2, 5, and 8 to include grade 3-4 AEs reported in $\geq$ 20% of patients.</span>
+<span id="cb24-189"><a href="#cb24-189"></a>These thresholds are chosen to demonstrate the filtering ability; they can be changed by varying parameter values in the <span class="in">`has_fraction_in_any_col`</span> function.</span>
+<span id="cb24-190"><a href="#cb24-190"></a></span>
+<span id="cb24-191"><a href="#cb24-191"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb24-192"><a href="#cb24-192"></a>full_table <span class="ot">&lt;-</span> <span class="fu">full_table_aet04_pi</span>(adsl, adae_max) <span class="sc">%&gt;%</span></span>
+<span id="cb24-193"><a href="#cb24-193"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-194"><a href="#cb24-194"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-195"><a href="#cb24-195"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-196"><a href="#cb24-196"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-197"><a href="#cb24-197"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-198"><a href="#cb24-198"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-199"><a href="#cb24-199"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-200"><a href="#cb24-200"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-201"><a href="#cb24-201"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-202"><a href="#cb24-202"></a>  )</span>
+<span id="cb24-203"><a href="#cb24-203"></a></span>
+<span id="cb24-204"><a href="#cb24-204"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-205"><a href="#cb24-205"></a></span>
+<span id="cb24-206"><a href="#cb24-206"></a>at_least_20percent_g34 <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.20</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">2</span>, <span class="dv">5</span>, <span class="dv">8</span>))</span>
+<span id="cb24-207"><a href="#cb24-207"></a></span>
+<span id="cb24-208"><a href="#cb24-208"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-209"><a href="#cb24-209"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-210"><a href="#cb24-210"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any <span class="sc">|</span> at_least_20percent_g34))</span>
+<span id="cb24-211"><a href="#cb24-211"></a></span>
+<span id="cb24-212"><a href="#cb24-212"></a>result</span>
+<span id="cb24-213"><a href="#cb24-213"></a><span class="in">```</span></span>
+<span id="cb24-214"><a href="#cb24-214"></a></span>
+<span id="cb24-215"><a href="#cb24-215"></a><span class="fu">## Standard Table with &lt;br/&gt; Modified Grade Grouping</span></span>
+<span id="cb24-216"><a href="#cb24-216"></a></span>
+<span id="cb24-217"><a href="#cb24-217"></a>Note: User can specify/modify the grouping of grades, as shown in this example.</span>
+<span id="cb24-218"><a href="#cb24-218"></a>In addition, the user needs to specify the column index for filtering the table.</span>
+<span id="cb24-219"><a href="#cb24-219"></a>The current example uses the "Any Grade" columns with a filtering threshold at 0.40; this can be changed by varying the parameter values in the <span class="in">`has_fraction_in_any_col`</span> function.</span>
+<span id="cb24-220"><a href="#cb24-220"></a></span>
+<span id="cb24-221"><a href="#cb24-221"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb24-222"><a href="#cb24-222"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb24-223"><a href="#cb24-223"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-224"><a href="#cb24-224"></a>  <span class="st">"Grade 1-2 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb24-225"><a href="#cb24-225"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb24-226"><a href="#cb24-226"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb24-227"><a href="#cb24-227"></a>)</span>
+<span id="cb24-228"><a href="#cb24-228"></a></span>
+<span id="cb24-229"><a href="#cb24-229"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb24-230"><a href="#cb24-230"></a></span>
+<span id="cb24-231"><a href="#cb24-231"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-232"><a href="#cb24-232"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-233"><a href="#cb24-233"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb24-234"><a href="#cb24-234"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb24-235"><a href="#cb24-235"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb24-236"><a href="#cb24-236"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb24-237"><a href="#cb24-237"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-238"><a href="#cb24-238"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-239"><a href="#cb24-239"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb24-240"><a href="#cb24-240"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb24-241"><a href="#cb24-241"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb24-242"><a href="#cb24-242"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb24-243"><a href="#cb24-243"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-244"><a href="#cb24-244"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb24-245"><a href="#cb24-245"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb24-246"><a href="#cb24-246"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb24-247"><a href="#cb24-247"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb24-248"><a href="#cb24-248"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb24-249"><a href="#cb24-249"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb24-250"><a href="#cb24-250"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-251"><a href="#cb24-251"></a>  <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-252"><a href="#cb24-252"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts) <span class="sc">%&gt;%</span></span>
+<span id="cb24-253"><a href="#cb24-253"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-254"><a href="#cb24-254"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-255"><a href="#cb24-255"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb24-256"><a href="#cb24-256"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-257"><a href="#cb24-257"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-258"><a href="#cb24-258"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-259"><a href="#cb24-259"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-260"><a href="#cb24-260"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb24-261"><a href="#cb24-261"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-262"><a href="#cb24-262"></a>  )</span>
+<span id="cb24-263"><a href="#cb24-263"></a></span>
+<span id="cb24-264"><a href="#cb24-264"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>))</span>
+<span id="cb24-265"><a href="#cb24-265"></a></span>
+<span id="cb24-266"><a href="#cb24-266"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-267"><a href="#cb24-267"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-268"><a href="#cb24-268"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb24-269"><a href="#cb24-269"></a></span>
+<span id="cb24-270"><a href="#cb24-270"></a>result</span>
+<span id="cb24-271"><a href="#cb24-271"></a><span class="in">```</span></span>
+<span id="cb24-272"><a href="#cb24-272"></a></span>
+<span id="cb24-273"><a href="#cb24-273"></a><span class="fu">## Standard Table with &lt;br/&gt; Overlapping Grade Groupings</span></span>
+<span id="cb24-274"><a href="#cb24-274"></a></span>
+<span id="cb24-275"><a href="#cb24-275"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-276"><a href="#cb24-276"></a>The current example uses column indices 1, 5, and 9 with a filtering threshold at 0.40 to demonstrate the filtering ability; any grade AEs reported in greater than 40% of patients are shown.</span>
+<span id="cb24-277"><a href="#cb24-277"></a>This can be changed by varying the parameter values in the <span class="in">`has_fraction_in_any_col`</span> function.</span>
+<span id="cb24-278"><a href="#cb24-278"></a></span>
+<span id="cb24-279"><a href="#cb24-279"></a><span class="in">```{r variant7, test = list(result_v7 = "result")}</span></span>
+<span id="cb24-280"><a href="#cb24-280"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb24-281"><a href="#cb24-281"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-282"><a href="#cb24-282"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb24-283"><a href="#cb24-283"></a>  <span class="st">"Grade 3-5 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-284"><a href="#cb24-284"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb24-285"><a href="#cb24-285"></a>)</span>
+<span id="cb24-286"><a href="#cb24-286"></a></span>
+<span id="cb24-287"><a href="#cb24-287"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb24-288"><a href="#cb24-288"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-289"><a href="#cb24-289"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-290"><a href="#cb24-290"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb24-291"><a href="#cb24-291"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb24-292"><a href="#cb24-292"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>, <span class="at">nested =</span> <span class="cn">FALSE</span>, <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb24-293"><a href="#cb24-293"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb24-294"><a href="#cb24-294"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-295"><a href="#cb24-295"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA System Organ Class"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-296"><a href="#cb24-296"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb24-297"><a href="#cb24-297"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb24-298"><a href="#cb24-298"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb24-299"><a href="#cb24-299"></a>    <span class="at">.labels =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb24-300"><a href="#cb24-300"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-301"><a href="#cb24-301"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb24-302"><a href="#cb24-302"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb24-303"><a href="#cb24-303"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb24-304"><a href="#cb24-304"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb24-305"><a href="#cb24-305"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb24-306"><a href="#cb24-306"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb24-307"><a href="#cb24-307"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-308"><a href="#cb24-308"></a>  <span class="fu">append_topleft</span>(<span class="st">"  MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-309"><a href="#cb24-309"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts) <span class="sc">%&gt;%</span></span>
+<span id="cb24-310"><a href="#cb24-310"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-311"><a href="#cb24-311"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb24-312"><a href="#cb24-312"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cont_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb24-313"><a href="#cb24-313"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-314"><a href="#cb24-314"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-315"><a href="#cb24-315"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-316"><a href="#cb24-316"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-317"><a href="#cb24-317"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>)),</span>
+<span id="cb24-318"><a href="#cb24-318"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-319"><a href="#cb24-319"></a>  )</span>
+<span id="cb24-320"><a href="#cb24-320"></a></span>
+<span id="cb24-321"><a href="#cb24-321"></a>at_least_40percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.4</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">9</span>))</span>
+<span id="cb24-322"><a href="#cb24-322"></a></span>
+<span id="cb24-323"><a href="#cb24-323"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-324"><a href="#cb24-324"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb24-325"><a href="#cb24-325"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_40percent_any))</span>
+<span id="cb24-326"><a href="#cb24-326"></a></span>
+<span id="cb24-327"><a href="#cb24-327"></a>result</span>
+<span id="cb24-328"><a href="#cb24-328"></a><span class="in">```</span></span>
+<span id="cb24-329"><a href="#cb24-329"></a></span>
+<span id="cb24-330"><a href="#cb24-330"></a><span class="fu">## Standard Table without SOCs</span></span>
+<span id="cb24-331"><a href="#cb24-331"></a></span>
+<span id="cb24-332"><a href="#cb24-332"></a>Note: User needs to specify the column index for filtering the table.</span>
+<span id="cb24-333"><a href="#cb24-333"></a>The current example uses column indices 1, 4, and 7 with a filtering threshold at 0.20 to demonstrate the filtering ability; any grade AEs (Preferred Terms Only) reported in greater than 20% of patients are shown.</span>
+<span id="cb24-334"><a href="#cb24-334"></a>This can be changed by varying the parameter values in the <span class="in">`has_fraction_in_any_col`</span> function.</span>
+<span id="cb24-335"><a href="#cb24-335"></a></span>
+<span id="cb24-336"><a href="#cb24-336"></a><span class="in">```{r variant8, test = list(result_v8 = "result")}</span></span>
+<span id="cb24-337"><a href="#cb24-337"></a>grade_groups <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb24-338"><a href="#cb24-338"></a>  <span class="st">"Any Grade (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-339"><a href="#cb24-339"></a>  <span class="st">"Grade 3-4 (%)"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb24-340"><a href="#cb24-340"></a>  <span class="st">"Grade 5 (%)"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb24-341"><a href="#cb24-341"></a>)</span>
+<span id="cb24-342"><a href="#cb24-342"></a></span>
+<span id="cb24-343"><a href="#cb24-343"></a>col_counts <span class="ot">&lt;-</span> <span class="fu">rep</span>(<span class="fu">table</span>(adsl<span class="sc">$</span>ACTARM), <span class="at">each =</span> <span class="fu">length</span>(grade_groups))</span>
+<span id="cb24-344"><a href="#cb24-344"></a></span>
+<span id="cb24-345"><a href="#cb24-345"></a>full_table <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb24-346"><a href="#cb24-346"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-347"><a href="#cb24-347"></a>  <span class="fu">split_cols_by_groups</span>(<span class="st">"MAXAETOXGR"</span>, <span class="at">groups =</span> grade_groups) <span class="sc">%&gt;%</span></span>
+<span id="cb24-348"><a href="#cb24-348"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb24-349"><a href="#cb24-349"></a>    <span class="st">"AEDECOD"</span>,</span>
+<span id="cb24-350"><a href="#cb24-350"></a>    <span class="at">na.rm =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb24-351"><a href="#cb24-351"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb24-352"><a href="#cb24-352"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb24-353"><a href="#cb24-353"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="fu">format_fraction_threshold</span>(<span class="fl">0.01</span>))</span>
+<span id="cb24-354"><a href="#cb24-354"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb24-355"><a href="#cb24-355"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA Preferred Term"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb24-356"><a href="#cb24-356"></a>  <span class="fu">build_table</span>(adae_max, <span class="at">col_counts =</span> col_counts)</span>
+<span id="cb24-357"><a href="#cb24-357"></a></span>
+<span id="cb24-358"><a href="#cb24-358"></a>at_least_20percent_any <span class="ot">&lt;-</span> <span class="fu">has_fraction_in_any_col</span>(<span class="at">atleast =</span> <span class="fl">0.2</span>, <span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>))</span>
+<span id="cb24-359"><a href="#cb24-359"></a></span>
+<span id="cb24-360"><a href="#cb24-360"></a>result <span class="ot">&lt;-</span> full_table <span class="sc">%&gt;%</span></span>
+<span id="cb24-361"><a href="#cb24-361"></a>  <span class="fu">prune_table</span>(<span class="fu">keep_rows</span>(at_least_20percent_any)) <span class="sc">%&gt;%</span></span>
+<span id="cb24-362"><a href="#cb24-362"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb24-363"><a href="#cb24-363"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb24-364"><a href="#cb24-364"></a>    <span class="at">scorefun =</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">4</span>, <span class="dv">7</span>)),</span>
+<span id="cb24-365"><a href="#cb24-365"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-366"><a href="#cb24-366"></a>  )</span>
+<span id="cb24-367"><a href="#cb24-367"></a></span>
+<span id="cb24-368"><a href="#cb24-368"></a>result</span>
+<span id="cb24-369"><a href="#cb24-369"></a><span class="in">```</span></span>
+<span id="cb24-370"><a href="#cb24-370"></a></span>
+<span id="cb24-371"><a href="#cb24-371"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb24-372"><a href="#cb24-372"></a></span>
+<span id="cb24-373"><a href="#cb24-373"></a><span class="fu">## `teal` App</span></span>
+<span id="cb24-374"><a href="#cb24-374"></a></span>
+<span id="cb24-375"><a href="#cb24-375"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb24-376"><a href="#cb24-376"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb24-377"><a href="#cb24-377"></a></span>
+<span id="cb24-378"><a href="#cb24-378"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb24-379"><a href="#cb24-379"></a><span class="fu">library</span>(scda)</span>
+<span id="cb24-380"><a href="#cb24-380"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb24-381"><a href="#cb24-381"></a><span class="fu">library</span>(tern)</span>
+<span id="cb24-382"><a href="#cb24-382"></a></span>
+<span id="cb24-383"><a href="#cb24-383"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb24-384"><a href="#cb24-384"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb24-385"><a href="#cb24-385"></a></span>
+<span id="cb24-386"><a href="#cb24-386"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb24-387"><a href="#cb24-387"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb24-388"><a href="#cb24-388"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb24-389"><a href="#cb24-389"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae),</span>
+<span id="cb24-390"><a href="#cb24-390"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb24-391"><a href="#cb24-391"></a><span class="st">    ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span>,</span>
+<span id="cb24-392"><a href="#cb24-392"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb24-393"><a href="#cb24-393"></a>  ),</span>
+<span id="cb24-394"><a href="#cb24-394"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb24-395"><a href="#cb24-395"></a>    <span class="fu">tm_t_events_by_grade</span>(</span>
+<span id="cb24-396"><a href="#cb24-396"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by Grade Table"</span>,</span>
+<span id="cb24-397"><a href="#cb24-397"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb24-398"><a href="#cb24-398"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb24-399"><a href="#cb24-399"></a>      <span class="at">col_by_grade =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb24-400"><a href="#cb24-400"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb24-401"><a href="#cb24-401"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb24-402"><a href="#cb24-402"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb24-403"><a href="#cb24-403"></a>      ),</span>
+<span id="cb24-404"><a href="#cb24-404"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb24-405"><a href="#cb24-405"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb24-406"><a href="#cb24-406"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb24-407"><a href="#cb24-407"></a>      ),</span>
+<span id="cb24-408"><a href="#cb24-408"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb24-409"><a href="#cb24-409"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETOXGR"</span>, <span class="st">"AESEV"</span>)),</span>
+<span id="cb24-410"><a href="#cb24-410"></a>        <span class="at">selected =</span> <span class="st">"AETOXGR"</span></span>
+<span id="cb24-411"><a href="#cb24-411"></a>      ),</span>
+<span id="cb24-412"><a href="#cb24-412"></a>      <span class="co"># List of column groups for grades used when `col_by_grade` = TRUE.</span></span>
+<span id="cb24-413"><a href="#cb24-413"></a>      <span class="at">grading_groups =</span> <span class="fu">list</span>(</span>
+<span id="cb24-414"><a href="#cb24-414"></a>        <span class="st">`</span><span class="at">Any Grade (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>),</span>
+<span id="cb24-415"><a href="#cb24-415"></a>        <span class="st">`</span><span class="at">Grade 3-4 (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>),</span>
+<span id="cb24-416"><a href="#cb24-416"></a>        <span class="st">`</span><span class="at">Grade 5 (%)</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb24-417"><a href="#cb24-417"></a>      )</span>
+<span id="cb24-418"><a href="#cb24-418"></a>    )</span>
+<span id="cb24-419"><a href="#cb24-419"></a>  )</span>
+<span id="cb24-420"><a href="#cb24-420"></a>)</span>
+<span id="cb24-421"><a href="#cb24-421"></a></span>
+<span id="cb24-422"><a href="#cb24-422"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb24-423"><a href="#cb24-423"></a><span class="in">```</span></span>
+<span id="cb24-424"><a href="#cb24-424"></a></span>
+<span id="cb24-425"><a href="#cb24-425"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb24-426"><a href="#cb24-426"></a></span>
+<span id="cb24-427"><a href="#cb24-427"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/tables/adverse-events/aet04_pi_files/figure-html/teal-1.png b/stable/tables/adverse-events/aet04_pi_files/figure-html/teal-1.png
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new file mode 100644
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--- /dev/null
+++ b/stable/tables/adverse-events/aet05.html
@@ -0,0 +1,2226 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET05</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
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+/* CSS for syntax highlighting */
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+  "copy-button": true,
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+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
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+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+cookieconsent.run({
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+</script><style>html{ scroll-behavior: smooth; }</style>
+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - AET05">
+<meta property="og:description" content="Adverse Event Rate Adjusted for Patient-Years at Risk – First Occurrence">
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+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
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+ <span class="menu-text">Efficacy</span></a>
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+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET05</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Event Rate Adjusted for Patient-Years at Risk – First Occurrence</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Setting Type of Confidence Interval</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet05_cache/html/setup_7f6d3479396af4fc61a9899a76218db0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>anl <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAM <span class="sc">==</span> <span class="st">"Time to first occurrence of any adverse event"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(is_event))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet05_cache/html/variant1_8e460759997b2a532ed75b04b845190e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  )</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                      A: Drug X        B: Placebo      C: Combination
+                                       (N=134)           (N=134)          (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+Total patient-years at risk             162.4             103.9            172.6     
+Number of adverse events observed         78               104               67      
+AE rate per 100 patient-years           48.03            100.14            38.82     
+95% CI                              (37.37, 58.69)   (80.89, 119.38)   (29.53, 48.12)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The type of confidence interval can be specified through the <code>conf_type</code> argument.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet05_cache/html/variant2_35b6c6f94b7091f3ffd1807aedde1850">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>      <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>      <span class="at">conf_type =</span> <span class="st">"exact"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>      <span class="at">num_pt_year =</span> <span class="dv">100</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>    )</span>
+<span id="cb4-11"><a href="#cb4-11"></a>  )</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-14"><a href="#cb4-14"></a></span>
+<span id="cb4-15"><a href="#cb4-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                      A: Drug X        B: Placebo      C: Combination
+                                       (N=134)           (N=134)          (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+Total patient-years at risk             162.4             103.9            172.6     
+Number of adverse events observed         78               104               67      
+AE rate per 100 patient-years           48.03            100.14            38.82     
+95% CI                              (37.97, 59.94)   (81.82, 121.34)   (30.09, 49.30)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="aet05_cache/html/teal_00f1a8f651fc5028b1233792d45170b5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-3"><a href="#cb6-3"></a></span>
+<span id="cb6-4"><a href="#cb6-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-5"><a href="#cb6-5"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a></span>
+<span id="cb6-7"><a href="#cb6-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-9"><a href="#cb6-9"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb6-10"><a href="#cb6-10"></a></span>
+<span id="cb6-11"><a href="#cb6-11"></a>adaette <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"AETTE1"</span>, <span class="st">"AETTE2"</span>, <span class="st">"AETTE3"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(is_event))</span>
+<span id="cb6-15"><a href="#cb6-15"></a></span>
+<span id="cb6-16"><a href="#cb6-16"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAETTE"</span>, adaette),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">code =</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a><span class="st">       ADAETTE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adaette"))</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a><span class="st">       ADAETTE &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a><span class="st">  dplyr::filter(PARAMCD %in% c("AETTE1", "AETTE2", "AETTE3")) %&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a><span class="st">  dplyr::mutate(is_event = CNSR == 0) %&gt;%</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a><span class="st">  dplyr::mutate(n_events = as.integer(is_event))'</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  ),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="fu">tm_t_events_patyear</span>(</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      <span class="at">label =</span> <span class="st">"AE rate adjusted for patient-years at risk Table"</span>,</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">dataname =</span> <span class="st">"ADAETTE"</span>,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>        <span class="at">selected =</span> <span class="st">"ARMCD"</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>      ),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-38"><a href="#cb6-38"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adaette, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb6-39"><a href="#cb6-39"></a>        <span class="at">selected =</span> <span class="st">"AETTE1"</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a>      ),</span>
+<span id="cb6-41"><a href="#cb6-41"></a>      <span class="at">events_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-42"><a href="#cb6-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adaette, <span class="st">"n_events"</span>),</span>
+<span id="cb6-43"><a href="#cb6-43"></a>        <span class="at">selected =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>      )</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    )</span>
+<span id="cb6-47"><a href="#cb6-47"></a>  )</span>
+<span id="cb6-48"><a href="#cb6-48"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:18:50.7364 pid:10802 token:[] teal.modules.clinical Initializing tm_t_events_patyear</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet05_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet05_cache/html/sessioninfo_34386f569c62adc534cc3a00c74df4c4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] scda_0.1.6                   dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet05_cache/html/snapshot_2e32fc6a1e8eb62508ff7c4b18c9a1e0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet05.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
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+    }
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+  // Dark / light mode switch
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+    setStyleSentinel(toAlternate);
+  };
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
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+  // Switch to dark mode if need be
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+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
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+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
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+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
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+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet04_pi.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET04_PI</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet05_all.html" class="pagination-link">
+        <span class="nav-page-text">AET05_ALL</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET05</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Event Rate Adjusted for Patient-Years at Risk -- First Occurrence</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a>anl <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAM <span class="sc">==</span> <span class="st">"Time to first occurrence of any adverse event"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(is_event))</span>
+<span id="cb12-31"><a href="#cb12-31"></a><span class="in">```</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a></span>
+<span id="cb12-33"><a href="#cb12-33"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a></span>
+<span id="cb12-35"><a href="#cb12-35"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-40"><a href="#cb12-40"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-41"><a href="#cb12-41"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb12-42"><a href="#cb12-42"></a>  )</span>
+<span id="cb12-43"><a href="#cb12-43"></a></span>
+<span id="cb12-44"><a href="#cb12-44"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-45"><a href="#cb12-45"></a></span>
+<span id="cb12-46"><a href="#cb12-46"></a>result</span>
+<span id="cb12-47"><a href="#cb12-47"></a><span class="in">```</span></span>
+<span id="cb12-48"><a href="#cb12-48"></a></span>
+<span id="cb12-49"><a href="#cb12-49"></a><span class="fu">## Table Setting Type of Confidence Interval</span></span>
+<span id="cb12-50"><a href="#cb12-50"></a></span>
+<span id="cb12-51"><a href="#cb12-51"></a>The type of confidence interval can be specified through the <span class="in">`conf_type`</span> argument.</span>
+<span id="cb12-52"><a href="#cb12-52"></a></span>
+<span id="cb12-53"><a href="#cb12-53"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-54"><a href="#cb12-54"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-55"><a href="#cb12-55"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb12-57"><a href="#cb12-57"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-58"><a href="#cb12-58"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-59"><a href="#cb12-59"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(</span>
+<span id="cb12-60"><a href="#cb12-60"></a>      <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb12-61"><a href="#cb12-61"></a>      <span class="at">conf_type =</span> <span class="st">"exact"</span>,</span>
+<span id="cb12-62"><a href="#cb12-62"></a>      <span class="at">num_pt_year =</span> <span class="dv">100</span></span>
+<span id="cb12-63"><a href="#cb12-63"></a>    )</span>
+<span id="cb12-64"><a href="#cb12-64"></a>  )</span>
+<span id="cb12-65"><a href="#cb12-65"></a></span>
+<span id="cb12-66"><a href="#cb12-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-67"><a href="#cb12-67"></a></span>
+<span id="cb12-68"><a href="#cb12-68"></a>result</span>
+<span id="cb12-69"><a href="#cb12-69"></a><span class="in">```</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a></span>
+<span id="cb12-71"><a href="#cb12-71"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-72"><a href="#cb12-72"></a></span>
+<span id="cb12-73"><a href="#cb12-73"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb12-77"><a href="#cb12-77"></a></span>
+<span id="cb12-78"><a href="#cb12-78"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-79"><a href="#cb12-79"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-80"><a href="#cb12-80"></a></span>
+<span id="cb12-81"><a href="#cb12-81"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-82"><a href="#cb12-82"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb12-83"><a href="#cb12-83"></a></span>
+<span id="cb12-84"><a href="#cb12-84"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-85"><a href="#cb12-85"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-86"><a href="#cb12-86"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb12-87"><a href="#cb12-87"></a></span>
+<span id="cb12-88"><a href="#cb12-88"></a>adaette <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"AETTE1"</span>, <span class="st">"AETTE2"</span>, <span class="st">"AETTE3"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-90"><a href="#cb12-90"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-91"><a href="#cb12-91"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(is_event))</span>
+<span id="cb12-92"><a href="#cb12-92"></a></span>
+<span id="cb12-93"><a href="#cb12-93"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-95"><a href="#cb12-95"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAETTE"</span>, adaette),</span>
+<span id="cb12-97"><a href="#cb12-97"></a>    <span class="at">code =</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a><span class="st">       ADAETTE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adaette"))</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a><span class="st">       ADAETTE &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb12-101"><a href="#cb12-101"></a><span class="st">  dplyr::filter(PARAMCD %in% c("AETTE1", "AETTE2", "AETTE3")) %&gt;%</span></span>
+<span id="cb12-102"><a href="#cb12-102"></a><span class="st">  dplyr::mutate(is_event = CNSR == 0) %&gt;%</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a><span class="st">  dplyr::mutate(n_events = as.integer(is_event))'</span>,</span>
+<span id="cb12-104"><a href="#cb12-104"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-105"><a href="#cb12-105"></a>  ),</span>
+<span id="cb12-106"><a href="#cb12-106"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-107"><a href="#cb12-107"></a>    <span class="fu">tm_t_events_patyear</span>(</span>
+<span id="cb12-108"><a href="#cb12-108"></a>      <span class="at">label =</span> <span class="st">"AE rate adjusted for patient-years at risk Table"</span>,</span>
+<span id="cb12-109"><a href="#cb12-109"></a>      <span class="at">dataname =</span> <span class="st">"ADAETTE"</span>,</span>
+<span id="cb12-110"><a href="#cb12-110"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-111"><a href="#cb12-111"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-112"><a href="#cb12-112"></a>        <span class="at">selected =</span> <span class="st">"ARMCD"</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a>      ),</span>
+<span id="cb12-114"><a href="#cb12-114"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-115"><a href="#cb12-115"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adaette, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-116"><a href="#cb12-116"></a>        <span class="at">selected =</span> <span class="st">"AETTE1"</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a>      ),</span>
+<span id="cb12-118"><a href="#cb12-118"></a>      <span class="at">events_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-119"><a href="#cb12-119"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adaette, <span class="st">"n_events"</span>),</span>
+<span id="cb12-120"><a href="#cb12-120"></a>        <span class="at">selected =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-121"><a href="#cb12-121"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-122"><a href="#cb12-122"></a>      )</span>
+<span id="cb12-123"><a href="#cb12-123"></a>    )</span>
+<span id="cb12-124"><a href="#cb12-124"></a>  )</span>
+<span id="cb12-125"><a href="#cb12-125"></a>)</span>
+<span id="cb12-126"><a href="#cb12-126"></a></span>
+<span id="cb12-127"><a href="#cb12-127"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-128"><a href="#cb12-128"></a><span class="in">```</span></span>
+<span id="cb12-129"><a href="#cb12-129"></a></span>
+<span id="cb12-130"><a href="#cb12-130"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-131"><a href="#cb12-131"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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\ No newline at end of file
diff --git a/stable/tables/adverse-events/aet05_all.html b/stable/tables/adverse-events/aet05_all.html
new file mode 100644
index 0000000000..1fcf795ef7
--- /dev/null
+++ b/stable/tables/adverse-events/aet05_all.html
@@ -0,0 +1,2256 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - AET05_ALL</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet01.html">Adverse Events</a></li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet05_all.html">AET05_ALL</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
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+<!-- sidebar -->
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+    <div class="sidebar-menu-container"> 
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
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+          </a> 
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET05_ALL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Event Rate Adjusted for Patient-Years at Risk – All Occurrences</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Setting Type of Confidence Interval</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet05_all_cache/html/setup_ef994c3e9768b108e0340c5bd25dd8b5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Create analysis dataset anl from the 2 parameters AEREPTTE &amp; AETOT1</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>anl_events <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AETOT1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">select</span>(USUBJID, ARM, ARMCD, <span class="at">n_events =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(n_events))</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>anl_tte <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AEREPTTE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">select</span>(USUBJID, ARM, ARMCD, AVAL)</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a>anl <span class="ot">&lt;-</span> <span class="fu">full_join</span>(anl_tte, anl_events, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet05_all_cache/html/variant1_ac1b66279686d4c651a0b50adcae6e2f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  )</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X         B: Placebo       C: Combination 
+                                        (N=134)           (N=134)            (N=132)     
+—————————————————————————————————————————————————————————————————————————————————————————
+Total patient-years at risk              337.9             331.8              341.6      
+Number of adverse events observed         343               380                397       
+AE rate per 100 patient-years           101.51             114.51             116.22     
+95% CI                              (90.77, 112.25)   (103.00, 126.02)   (104.79, 127.65)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The type of confidence interval can be specified through the <code>conf_type</code> argument.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet05_all_cache/html/variant2_c13b6f49153149adeb76f79dc4c5aeeb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">conf_type =</span> <span class="st">"exact"</span>, <span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  )</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X         B: Placebo       C: Combination 
+                                        (N=134)           (N=134)            (N=132)     
+—————————————————————————————————————————————————————————————————————————————————————————
+Total patient-years at risk              337.9             331.8              341.6      
+Number of adverse events observed         343               380                397       
+AE rate per 100 patient-years           101.51             114.51             116.22     
+95% CI                              (91.05, 112.84)   (103.28, 126.62)   (105.07, 128.24)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="aet05_all_cache/html/teal_db248ebb40d092cc08026bd620425303">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(teal)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a><span class="co"># Create analysis dataset anl from the 2 parameters AEREPTTE &amp; AETOT1</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>anl_events <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"AETOT1"</span>, <span class="st">"AETOT2"</span>, <span class="st">"AETOT3"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>  <span class="fu">select</span>(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, <span class="at">n_events =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(n_events))</span>
+<span id="cb6-17"><a href="#cb6-17"></a></span>
+<span id="cb6-18"><a href="#cb6-18"></a>anl_tte <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AEREPTTE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">select</span>(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)</span>
+<span id="cb6-21"><a href="#cb6-21"></a></span>
+<span id="cb6-22"><a href="#cb6-22"></a>adaette <span class="ot">&lt;-</span> <span class="fu">full_join</span>(anl_tte, anl_events, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"STUDYID"</span>, <span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>))</span>
+<span id="cb6-23"><a href="#cb6-23"></a></span>
+<span id="cb6-24"><a href="#cb6-24"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAETTE"</span>, adaette),</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">code =</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a><span class="st">      ADAETTE &lt;- synthetic_cdisc_dataset("latest", "adaette")</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a><span class="st">      ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a><span class="st">      ADAETTE &lt;- df_explicit_na(ADAETTE)</span></span>
+<span id="cb6-33"><a href="#cb6-33"></a><span class="st">      anl_events &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a><span class="st">        filter(PARAMCD %in%  c("AETOT1", "AETOT2", "AETOT3")) %&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a><span class="st">        select(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, n_events = AVAL) %&gt;%</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a><span class="st">        mutate(n_events = as.integer(n_events))</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a><span class="st">      anl_tte &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a><span class="st">        filter(PARAMCD == "AEREPTTE") %&gt;%</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a><span class="st">        select(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a><span class="st">      ADAETTE &lt;- full_join(anl_tte, anl_events, by = c("USUBJID", "STUDYID", "ARM", "ARMCD"))'</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>  ),</span>
+<span id="cb6-43"><a href="#cb6-43"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="fu">tm_t_events_patyear</span>(</span>
+<span id="cb6-45"><a href="#cb6-45"></a>      <span class="at">label =</span> <span class="st">"AE Rate Adjusted for Patient-Years at Risk - All Occurrences Table"</span>,</span>
+<span id="cb6-46"><a href="#cb6-46"></a>      <span class="at">dataname =</span> <span class="st">"ADAETTE"</span>,</span>
+<span id="cb6-47"><a href="#cb6-47"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-48"><a href="#cb6-48"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-49"><a href="#cb6-49"></a>        <span class="at">selected =</span> <span class="st">"ARMCD"</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a>      ),</span>
+<span id="cb6-51"><a href="#cb6-51"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-52"><a href="#cb6-52"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adaette, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb6-53"><a href="#cb6-53"></a>        <span class="at">selected =</span> <span class="st">"AETOT1"</span></span>
+<span id="cb6-54"><a href="#cb6-54"></a>      ),</span>
+<span id="cb6-55"><a href="#cb6-55"></a>      <span class="at">events_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-56"><a href="#cb6-56"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adaette, <span class="st">"n_events"</span>),</span>
+<span id="cb6-57"><a href="#cb6-57"></a>        <span class="at">selected =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb6-58"><a href="#cb6-58"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a>      )</span>
+<span id="cb6-60"><a href="#cb6-60"></a>    )</span>
+<span id="cb6-61"><a href="#cb6-61"></a>  )</span>
+<span id="cb6-62"><a href="#cb6-62"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:17:40.9119 pid:10605 token:[] teal.modules.clinical Initializing tm_t_events_patyear</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet05_all_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet05_all_cache/html/sessioninfo_ff091a063c877e5b6004c02e7ea3cce0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet05_all_cache/html/snapshot_c16bfdd28e3644d617002a49b698611c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet05_all.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet05.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET05</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet06.html" class="pagination-link">
+        <span class="nav-page-text">AET06</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET05_ALL</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Event Rate Adjusted for Patient-Years at Risk -- All Occurrences</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a><span class="co"># Create analysis dataset anl from the 2 parameters AEREPTTE &amp; AETOT1</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a>anl_events <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AETOT1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">select</span>(USUBJID, ARM, ARMCD, <span class="at">n_events =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(n_events))</span>
+<span id="cb12-32"><a href="#cb12-32"></a></span>
+<span id="cb12-33"><a href="#cb12-33"></a>anl_tte <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AEREPTTE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>  <span class="fu">select</span>(USUBJID, ARM, ARMCD, AVAL)</span>
+<span id="cb12-36"><a href="#cb12-36"></a></span>
+<span id="cb12-37"><a href="#cb12-37"></a>anl <span class="ot">&lt;-</span> <span class="fu">full_join</span>(anl_tte, anl_events, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>))</span>
+<span id="cb12-38"><a href="#cb12-38"></a><span class="in">```</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a></span>
+<span id="cb12-40"><a href="#cb12-40"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a></span>
+<span id="cb12-42"><a href="#cb12-42"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-43"><a href="#cb12-43"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb12-46"><a href="#cb12-46"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-48"><a href="#cb12-48"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb12-49"><a href="#cb12-49"></a>  )</span>
+<span id="cb12-50"><a href="#cb12-50"></a></span>
+<span id="cb12-51"><a href="#cb12-51"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-52"><a href="#cb12-52"></a>result</span>
+<span id="cb12-53"><a href="#cb12-53"></a><span class="in">```</span></span>
+<span id="cb12-54"><a href="#cb12-54"></a></span>
+<span id="cb12-55"><a href="#cb12-55"></a><span class="fu">## Table Setting Type of Confidence Interval</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a></span>
+<span id="cb12-57"><a href="#cb12-57"></a>The type of confidence interval can be specified through the <span class="in">`conf_type`</span> argument.</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a>  <span class="fu">estimate_incidence_rate</span>(</span>
+<span id="cb12-63"><a href="#cb12-63"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-64"><a href="#cb12-64"></a>    <span class="at">n_events =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-65"><a href="#cb12-65"></a>    <span class="at">control =</span> <span class="fu">control_incidence_rate</span>(<span class="at">conf_type =</span> <span class="st">"exact"</span>, <span class="at">num_pt_year =</span> <span class="dv">100</span>)</span>
+<span id="cb12-66"><a href="#cb12-66"></a>  )</span>
+<span id="cb12-67"><a href="#cb12-67"></a></span>
+<span id="cb12-68"><a href="#cb12-68"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-69"><a href="#cb12-69"></a>result</span>
+<span id="cb12-70"><a href="#cb12-70"></a><span class="in">```</span></span>
+<span id="cb12-71"><a href="#cb12-71"></a></span>
+<span id="cb12-72"><a href="#cb12-72"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-73"><a href="#cb12-73"></a></span>
+<span id="cb12-74"><a href="#cb12-74"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-75"><a href="#cb12-75"></a></span>
+<span id="cb12-76"><a href="#cb12-76"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-77"><a href="#cb12-77"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a></span>
+<span id="cb12-79"><a href="#cb12-79"></a><span class="fu">library</span>(teal)</span>
+<span id="cb12-80"><a href="#cb12-80"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-81"><a href="#cb12-81"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-82"><a href="#cb12-82"></a></span>
+<span id="cb12-83"><a href="#cb12-83"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-84"><a href="#cb12-84"></a>adaette <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb12-85"><a href="#cb12-85"></a></span>
+<span id="cb12-86"><a href="#cb12-86"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-87"><a href="#cb12-87"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-88"><a href="#cb12-88"></a>adaette <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adaette)</span>
+<span id="cb12-89"><a href="#cb12-89"></a></span>
+<span id="cb12-90"><a href="#cb12-90"></a><span class="co"># Create analysis dataset anl from the 2 parameters AEREPTTE &amp; AETOT1</span></span>
+<span id="cb12-91"><a href="#cb12-91"></a>anl_events <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-92"><a href="#cb12-92"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"AETOT1"</span>, <span class="st">"AETOT2"</span>, <span class="st">"AETOT3"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="fu">select</span>(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, <span class="at">n_events =</span> AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="fu">mutate</span>(<span class="at">n_events =</span> <span class="fu">as.integer</span>(n_events))</span>
+<span id="cb12-95"><a href="#cb12-95"></a></span>
+<span id="cb12-96"><a href="#cb12-96"></a>anl_tte <span class="ot">&lt;-</span> adaette <span class="sc">%&gt;%</span></span>
+<span id="cb12-97"><a href="#cb12-97"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"AEREPTTE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>  <span class="fu">select</span>(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)</span>
+<span id="cb12-99"><a href="#cb12-99"></a></span>
+<span id="cb12-100"><a href="#cb12-100"></a>adaette <span class="ot">&lt;-</span> <span class="fu">full_join</span>(anl_tte, anl_events, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"STUDYID"</span>, <span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>))</span>
+<span id="cb12-101"><a href="#cb12-101"></a></span>
+<span id="cb12-102"><a href="#cb12-102"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-103"><a href="#cb12-103"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-104"><a href="#cb12-104"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb12-105"><a href="#cb12-105"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAETTE"</span>, adaette),</span>
+<span id="cb12-106"><a href="#cb12-106"></a>    <span class="at">code =</span></span>
+<span id="cb12-107"><a href="#cb12-107"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb12-108"><a href="#cb12-108"></a><span class="st">      ADAETTE &lt;- synthetic_cdisc_dataset("latest", "adaette")</span></span>
+<span id="cb12-109"><a href="#cb12-109"></a><span class="st">      ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb12-110"><a href="#cb12-110"></a><span class="st">      ADAETTE &lt;- df_explicit_na(ADAETTE)</span></span>
+<span id="cb12-111"><a href="#cb12-111"></a><span class="st">      anl_events &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb12-112"><a href="#cb12-112"></a><span class="st">        filter(PARAMCD %in%  c("AETOT1", "AETOT2", "AETOT3")) %&gt;%</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a><span class="st">        select(USUBJID, STUDYID, PARAMCD, ARM, ARMCD, n_events = AVAL) %&gt;%</span></span>
+<span id="cb12-114"><a href="#cb12-114"></a><span class="st">        mutate(n_events = as.integer(n_events))</span></span>
+<span id="cb12-115"><a href="#cb12-115"></a><span class="st">      anl_tte &lt;- ADAETTE %&gt;%</span></span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="st">        filter(PARAMCD == "AEREPTTE") %&gt;%</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="st">        select(USUBJID, STUDYID, ARM, ARMCD, AVAL, AVALU)</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="st">      ADAETTE &lt;- full_join(anl_tte, anl_events, by = c("USUBJID", "STUDYID", "ARM", "ARMCD"))'</span>,</span>
+<span id="cb12-119"><a href="#cb12-119"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-120"><a href="#cb12-120"></a>  ),</span>
+<span id="cb12-121"><a href="#cb12-121"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-122"><a href="#cb12-122"></a>    <span class="fu">tm_t_events_patyear</span>(</span>
+<span id="cb12-123"><a href="#cb12-123"></a>      <span class="at">label =</span> <span class="st">"AE Rate Adjusted for Patient-Years at Risk - All Occurrences Table"</span>,</span>
+<span id="cb12-124"><a href="#cb12-124"></a>      <span class="at">dataname =</span> <span class="st">"ADAETTE"</span>,</span>
+<span id="cb12-125"><a href="#cb12-125"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-126"><a href="#cb12-126"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-127"><a href="#cb12-127"></a>        <span class="at">selected =</span> <span class="st">"ARMCD"</span></span>
+<span id="cb12-128"><a href="#cb12-128"></a>      ),</span>
+<span id="cb12-129"><a href="#cb12-129"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-130"><a href="#cb12-130"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adaette, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb12-131"><a href="#cb12-131"></a>        <span class="at">selected =</span> <span class="st">"AETOT1"</span></span>
+<span id="cb12-132"><a href="#cb12-132"></a>      ),</span>
+<span id="cb12-133"><a href="#cb12-133"></a>      <span class="at">events_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-134"><a href="#cb12-134"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adaette, <span class="st">"n_events"</span>),</span>
+<span id="cb12-135"><a href="#cb12-135"></a>        <span class="at">selected =</span> <span class="st">"n_events"</span>,</span>
+<span id="cb12-136"><a href="#cb12-136"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-137"><a href="#cb12-137"></a>      )</span>
+<span id="cb12-138"><a href="#cb12-138"></a>    )</span>
+<span id="cb12-139"><a href="#cb12-139"></a>  )</span>
+<span id="cb12-140"><a href="#cb12-140"></a>)</span>
+<span id="cb12-141"><a href="#cb12-141"></a></span>
+<span id="cb12-142"><a href="#cb12-142"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-143"><a href="#cb12-143"></a><span class="in">```</span></span>
+<span id="cb12-144"><a href="#cb12-144"></a></span>
+<span id="cb12-145"><a href="#cb12-145"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-146"><a href="#cb12-146"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET06</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events by Baseline Characteristic</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Adverse Events by Sex</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Adverse Events by Other Baseline <br> Characteristics (e.g.&nbsp;Biomarker Group)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Adverse Events by Baseline Characteristic <br> from ADSUB (e.g.&nbsp;BMI Category)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Adverse Events by Regrouped Baseline <br> Characteristics (e.g.&nbsp;Race)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Adverse Events by Baseline Characteristics <br> (e.g.&nbsp;Sex) Including High-Level Terms</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet06_cache/html/setup_87d8c50ff65d3bc95d54a4d2a4a6df8a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adsub <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsub"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsub_bmi <span class="ot">&lt;-</span> adsub <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"BBMISI"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">select</span>(STUDYID, USUBJID, AVALCAT1) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(AVALCAT1, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt;18.5"</span>, <span class="st">"18.5 - 24.9"</span>, <span class="st">"25 - 29.9"</span>, <span class="st">"&gt;30"</span>))</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  )</span>
+<span id="cb1-15"><a href="#cb1-15"></a></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">RACE1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      RACE <span class="sc">==</span> <span class="st">"WHITE"</span> <span class="sc">~</span> <span class="st">"WHITE"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NON-WHITE"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>    ),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">RACE1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      RACE1,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"WHITE"</span>, <span class="st">"NON-WHITE"</span>)</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    )</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">left_join</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">y =</span> adsub_bmi,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-30"><a href="#cb1-30"></a>  )</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb1-33"><a href="#cb1-33"></a></span>
+<span id="cb1-34"><a href="#cb1-34"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">RACE1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      RACE <span class="sc">==</span> <span class="st">"WHITE"</span> <span class="sc">~</span> <span class="st">"WHITE"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NON-WHITE"</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>    ),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">RACE1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      RACE1,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"WHITE"</span>, <span class="st">"NON-WHITE"</span>)</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    )</span>
+<span id="cb1-44"><a href="#cb1-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">left_join</span>(</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">y =</span> adsub_bmi,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-48"><a href="#cb1-48"></a>  )</span>
+<span id="cb1-49"><a href="#cb1-49"></a></span>
+<span id="cb1-50"><a href="#cb1-50"></a><span class="fu">var_labels</span>(adae) <span class="ot">&lt;-</span> <span class="fu">c</span>(adae_labels, <span class="st">"RACE1"</span> <span class="ot">=</span> <span class="st">"RACE WHITE/NON-WHITE"</span>, <span class="st">"AVALCAT1"</span> <span class="ot">=</span> <span class="st">"Baseline BMI Category"</span>)</span>
+<span id="cb1-51"><a href="#cb1-51"></a></span>
+<span id="cb1-52"><a href="#cb1-52"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-54"><a href="#cb1-54"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-55"><a href="#cb1-55"></a>adsub_bmi <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsub_bmi)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet06_cache/html/variant1_e7eeabb20dfb049fba6c16cc8697fc71">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>    )</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>    )</span>
+<span id="cb2-29"><a href="#cb2-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-32"><a href="#cb2-32"></a></span>
+<span id="cb2-33"><a href="#cb2-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-37"><a href="#cb2-37"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb2-43"><a href="#cb2-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-46"><a href="#cb2-46"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-47"><a href="#cb2-47"></a>  )</span>
+<span id="cb2-48"><a href="#cb2-48"></a></span>
+<span id="cb2-49"><a href="#cb2-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                          A: Drug X                B: Placebo              C: Combination     
+  Dictionary-Derived Term                                        F            M            F            M            F            M     
+                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     72 (91.1%)   50 (90.9%)   77 (93.9%)   46 (88.5%)   65 (92.9%)   55 (88.7%)
+Overall total number of events                                  377          232          419          203          378          325    
+cl A.1                                                                                                                                  
+  Total number of patients with at least one adverse event   53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)
+  Total number of events                                         85           47           93           37           86           74    
+  dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)
+  dcd A.1.1.1.2                                              32 (40.5%)   16 (29.1%)   33 (40.2%)   15 (28.8%)   24 (34.3%)   26 (41.9%)
+cl B.2                                                                                                                                  
+  Total number of patients with at least one adverse event   46 (58.2%)   33 (60.0%)   45 (54.9%)   29 (55.8%)   44 (62.9%)   41 (66.1%)
+  Total number of events                                         81           48           86           52           64           79    
+  dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)
+  dcd B.2.1.2.1                                              29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)
+cl D.1                                                                                                                                  
+  Total number of patients with at least one adverse event   45 (57.0%)   34 (61.8%)   40 (48.8%)   27 (51.9%)   41 (58.6%)   39 (62.9%)
+  Total number of events                                         72           55           64           42           73           62    
+  dcd D.1.1.1.1                                              25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)
+  dcd D.1.1.4.2                                              30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)
+cl D.2                                                                                                                                  
+  Total number of patients with at least one adverse event   26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+  Total number of events                                         35           27           49           23           43           31    
+  dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+cl B.1                                                                                                                                  
+  Total number of patients with at least one adverse event   28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)
+  Total number of events                                         33           23           36           24           35           27    
+  dcd B.1.1.1.1                                              28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)
+cl C.2                                                                                                                                  
+  Total number of patients with at least one adverse event   23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)
+  Total number of events                                         32           16           39           14           33           32    
+  dcd C.2.1.2.1                                              23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)
+cl C.1                                                                                                                                  
+  Total number of patients with at least one adverse event   30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)
+  Total number of events                                         39           16           52           11           44           20    
+  dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet06_cache/html/variant2_2e65a71241611c8548f213f00bfc44db">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"BMRKR2"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>    )</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>    )</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-32"><a href="#cb4-32"></a></span>
+<span id="cb4-33"><a href="#cb4-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-37"><a href="#cb4-37"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb4-40"><a href="#cb4-40"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb4-42"><a href="#cb4-42"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb4-43"><a href="#cb4-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-47"><a href="#cb4-47"></a>  )</span>
+<span id="cb4-48"><a href="#cb4-48"></a></span>
+<span id="cb4-49"><a href="#cb4-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                A: Drug X                              B: Placebo                           C: Combination           
+  Dictionary-Derived Term                                       LOW         MEDIUM        HIGH         LOW         MEDIUM        HIGH         LOW         MEDIUM        HIGH   
+                                                               (N=50)       (N=37)       (N=47)       (N=45)       (N=56)       (N=33)       (N=40)       (N=42)       (N=50)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     46 (92.0%)   34 (91.9%)   42 (89.4%)   40 (88.9%)   53 (94.6%)   30 (90.9%)   36 (90.0%)   39 (92.9%)   45 (90.0%)
+Overall total number of events                                  248          166          195          196          261          165          220          258          225    
+cl A.1                                                                                                                                                                         
+  Total number of patients with at least one adverse event   31 (62.0%)   19 (51.4%)   28 (59.6%)   25 (55.6%)   31 (55.4%)   19 (57.6%)   28 (70.0%)   30 (71.4%)   31 (62.0%)
+  Total number of events                                         53           34           45           46           54           30           61           51           48    
+  dcd A.1.1.1.1                                              22 (44.0%)   10 (27.0%)   18 (38.3%)   14 (31.1%)   20 (35.7%)   11 (33.3%)   21 (52.5%)   24 (57.1%)   18 (36.0%)
+  dcd A.1.1.1.2                                              17 (34.0%)   13 (35.1%)   18 (38.3%)   18 (40.0%)   18 (32.1%)   12 (36.4%)   18 (45.0%)   14 (33.3%)   18 (36.0%)
+cl B.2                                                                                                                                                                         
+  Total number of patients with at least one adverse event   34 (68.0%)   21 (56.8%)   24 (51.1%)   23 (51.1%)   33 (58.9%)   18 (54.5%)   24 (60.0%)   27 (64.3%)   34 (68.0%)
+  Total number of events                                         53           37           39           40           61           37           40           47           56    
+  dcd B.2.2.3.1                                              21 (42.0%)   13 (35.1%)   14 (29.8%)   18 (40.0%)   22 (39.3%)   14 (42.4%)   16 (40.0%)   15 (35.7%)   20 (40.0%)
+  dcd B.2.1.2.1                                              21 (42.0%)   11 (29.7%)   17 (36.2%)   11 (24.4%)   21 (37.5%)   12 (36.4%)   13 (32.5%)   17 (40.5%)   22 (44.0%)
+cl D.1                                                                                                                                                                         
+  Total number of patients with at least one adverse event   34 (68.0%)   21 (56.8%)   24 (51.1%)   18 (40.0%)   33 (58.9%)   16 (48.5%)   25 (62.5%)   31 (73.8%)   24 (48.0%)
+  Total number of events                                         51           35           41           27           49           30           45           53           37    
+  dcd D.1.1.1.1                                              19 (38.0%)   16 (43.2%)   15 (31.9%)   13 (28.9%)   19 (33.9%)   10 (30.3%)   14 (35.0%)   22 (52.4%)   15 (30.0%)
+  dcd D.1.1.4.2                                              21 (42.0%)   9 (24.3%)    18 (38.3%)   9 (20.0%)    20 (35.7%)   13 (39.4%)   17 (42.5%)   18 (42.9%)   15 (30.0%)
+cl D.2                                                                                                                                                                         
+  Total number of patients with at least one adverse event   20 (40.0%)   12 (32.4%)   15 (31.9%)   19 (42.2%)   22 (39.3%)   17 (51.5%)   13 (32.5%)   23 (54.8%)   21 (42.0%)
+  Total number of events                                         27           13           22           23           26           23           17           33           24    
+  dcd D.2.1.5.3                                              20 (40.0%)   12 (32.4%)   15 (31.9%)   19 (42.2%)   22 (39.3%)   17 (51.5%)   13 (32.5%)   23 (54.8%)   21 (42.0%)
+cl B.1                                                                                                                                                                         
+  Total number of patients with at least one adverse event   14 (28.0%)   14 (37.8%)   19 (40.4%)   15 (33.3%)   24 (42.9%)   10 (30.3%)   14 (35.0%)   15 (35.7%)   14 (28.0%)
+  Total number of events                                         16           19           21           18           25           17           19           25           18    
+  dcd B.1.1.1.1                                              14 (28.0%)   14 (37.8%)   19 (40.4%)   15 (33.3%)   24 (42.9%)   10 (30.3%)   14 (35.0%)   15 (35.7%)   14 (28.0%)
+cl C.2                                                                                                                                                                         
+  Total number of patients with at least one adverse event   18 (36.0%)   8 (21.6%)    9 (19.1%)    15 (33.3%)   22 (39.3%)   11 (33.3%)   18 (45.0%)   17 (40.5%)   20 (40.0%)
+  Total number of events                                         27           9            12           18           23           12           20           20           25    
+  dcd C.2.1.2.1                                              18 (36.0%)   8 (21.6%)    9 (19.1%)    15 (33.3%)   22 (39.3%)   11 (33.3%)   18 (45.0%)   17 (40.5%)   20 (40.0%)
+cl C.1                                                                                                                                                                         
+  Total number of patients with at least one adverse event   17 (34.0%)   14 (37.8%)   12 (25.5%)   17 (37.8%)   17 (30.4%)   12 (36.4%)   12 (30.0%)   17 (40.5%)   14 (28.0%)
+  Total number of events                                         21           19           15           24           23           16           18           29           17    
+  dcd C.1.1.1.3                                              17 (34.0%)   14 (37.8%)   12 (25.5%)   17 (37.8%)   17 (30.4%)   12 (36.4%)   12 (30.0%)   17 (40.5%)   14 (28.0%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet06_cache/html/variant3_4e6704b0c32ec8f4b6234f1a64f63a25">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVALCAT1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb6-11"><a href="#cb6-11"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>    )</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb6-21"><a href="#cb6-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>    )</span>
+<span id="cb6-29"><a href="#cb6-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb6-32"><a href="#cb6-32"></a></span>
+<span id="cb6-33"><a href="#cb6-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb6-36"><a href="#cb6-36"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb6-37"><a href="#cb6-37"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb6-43"><a href="#cb6-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-44"><a href="#cb6-44"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb6-47"><a href="#cb6-47"></a>  )</span>
+<span id="cb6-48"><a href="#cb6-48"></a></span>
+<span id="cb6-49"><a href="#cb6-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                       A: Drug X                                          B: Placebo                                         C: Combination                  
+  Dictionary-Derived Term                                      &lt;18.5      18.5 - 24.9   25 - 29.9      &gt;30         &lt;18.5      18.5 - 24.9   25 - 29.9      &gt;30         &lt;18.5      18.5 - 24.9   25 - 29.9       &gt;30    
+                                                               (N=44)       (N=17)       (N=11)       (N=62)       (N=37)       (N=18)       (N=10)       (N=69)       (N=28)       (N=20)        (N=18)       (N=66)  
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     41 (93.2%)   14 (82.4%)    11 (100%)   56 (90.3%)   35 (94.6%)   16 (88.9%)    9 (90.0%)   63 (91.3%)   25 (89.3%)   19 (95.0%)    15 (83.3%)   61 (92.4%)
+Overall total number of events                                  186           80           66          277          174           89           47          312          137           129          100          337    
+cl A.1                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   23 (52.3%)   12 (70.6%)    7 (63.6%)   36 (58.1%)   19 (51.4%)   10 (55.6%)    6 (60.0%)   40 (58.0%)   16 (57.1%)   13 (65.0%)    14 (77.8%)   46 (69.7%)
+  Total number of events                                         38           22           13           59           35           22            6           67           30           23            30           77    
+  dcd A.1.1.1.1                                              14 (31.8%)    7 (41.2%)    3 (27.3%)   26 (41.9%)   12 (32.4%)    6 (33.3%)    4 (40.0%)   23 (33.3%)   12 (42.9%)    7 (35.0%)    13 (72.2%)   31 (47.0%)
+  dcd A.1.1.1.2                                              15 (34.1%)    8 (47.1%)    5 (45.5%)   20 (32.3%)   12 (32.4%)    8 (44.4%)    2 (20.0%)   26 (37.7%)   9 (32.1%)     7 (35.0%)    7 (38.9%)    27 (40.9%)
+cl B.2                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   23 (52.3%)   10 (58.8%)    8 (72.7%)   38 (61.3%)   21 (56.8%)    8 (44.4%)    7 (70.0%)   38 (55.1%)   16 (57.1%)   16 (80.0%)    12 (66.7%)   41 (62.1%)
+  Total number of events                                         37           19           12           61           41           18           12           67           28           28            18           69    
+  dcd B.2.2.3.1                                              13 (29.5%)    7 (41.2%)    6 (54.5%)   22 (35.5%)   14 (37.8%)    7 (38.9%)    6 (60.0%)   27 (39.1%)   7 (25.0%)    13 (65.0%)    5 (27.8%)    26 (39.4%)
+  dcd B.2.1.2.1                                              14 (31.8%)    8 (47.1%)    4 (36.4%)   23 (37.1%)   14 (37.8%)    6 (33.3%)    4 (40.0%)   20 (29.0%)   13 (46.4%)    8 (40.0%)    8 (44.4%)    23 (34.8%)
+cl D.1                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   24 (54.5%)    9 (52.9%)    8 (72.7%)   38 (61.3%)   18 (48.6%)    5 (27.8%)    7 (70.0%)   37 (53.6%)   15 (53.6%)   12 (60.0%)    11 (61.1%)   42 (63.6%)
+  Total number of events                                         38           11           17           61           30           11           14           51           30           23            16           66    
+  dcd D.1.1.1.1                                              13 (29.5%)    7 (41.2%)    7 (63.6%)   23 (37.1%)   13 (35.1%)    3 (16.7%)    4 (40.0%)   22 (31.9%)   12 (42.9%)    6 (30.0%)    8 (44.4%)    25 (37.9%)
+  dcd D.1.1.4.2                                              16 (36.4%)    4 (23.5%)    6 (54.5%)   22 (35.5%)   10 (27.0%)    4 (22.2%)    5 (50.0%)   23 (33.3%)   10 (35.7%)    9 (45.0%)    6 (33.3%)    25 (37.9%)
+cl D.2                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   14 (31.8%)    7 (41.2%)    5 (45.5%)   21 (33.9%)   14 (37.8%)   10 (55.6%)    4 (40.0%)   30 (43.5%)   13 (46.4%)   10 (50.0%)    7 (38.9%)    27 (40.9%)
+  Total number of events                                         20            7           10           25           17           14            5           36           18           15            10           31    
+  dcd D.2.1.5.3                                              14 (31.8%)    7 (41.2%)    5 (45.5%)   21 (33.9%)   14 (37.8%)   10 (55.6%)    4 (40.0%)   30 (43.5%)   13 (46.4%)   10 (50.0%)    7 (38.9%)    27 (40.9%)
+cl B.1                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   17 (38.6%)    5 (29.4%)    7 (63.6%)   18 (29.0%)   14 (37.8%)    8 (44.4%)    4 (40.0%)   23 (33.3%)   7 (25.0%)    10 (50.0%)    7 (38.9%)    19 (28.8%)
+  Total number of events                                         22            5            7           22           16           11            4           29           11           12            8            31    
+  dcd B.1.1.1.1                                              17 (38.6%)    5 (29.4%)    7 (63.6%)   18 (29.0%)   14 (37.8%)    8 (44.4%)    4 (40.0%)   23 (33.3%)   7 (25.0%)    10 (50.0%)    7 (38.9%)    19 (28.8%)
+cl C.2                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   14 (31.8%)    4 (23.5%)    2 (18.2%)   15 (24.2%)   15 (40.5%)    5 (27.8%)    4 (40.0%)   24 (34.8%)   10 (35.7%)   13 (65.0%)    8 (44.4%)    24 (36.4%)
+  Total number of events                                         17            9            3           19           15            6            5           27           12           16            9            28    
+  dcd C.2.1.2.1                                              14 (31.8%)    4 (23.5%)    2 (18.2%)   15 (24.2%)   15 (40.5%)    5 (27.8%)    4 (40.0%)   24 (34.8%)   10 (35.7%)   13 (65.0%)    8 (44.4%)    24 (36.4%)
+cl C.1                                                                                                                                                                                                                 
+  Total number of patients with at least one adverse event   11 (25.0%)    4 (23.5%)    4 (36.4%)   24 (38.7%)   13 (35.1%)    6 (33.3%)    1 (10.0%)   26 (37.7%)   6 (21.4%)     7 (35.0%)    6 (33.3%)    24 (36.4%)
+  Total number of events                                         14            7            4           30           20            7            1           35           8            12            9            35    
+  dcd C.1.1.1.3                                              11 (25.0%)    4 (23.5%)    4 (36.4%)   24 (38.7%)   13 (35.1%)    6 (33.3%)    1 (10.0%)   26 (37.7%)   6 (21.4%)     7 (35.0%)    6 (33.3%)    24 (36.4%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="aet06_cache/html/variant4_9871cfbdd39a77dda438d007a2b508d0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"RACE1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>    )</span>
+<span id="cb8-13"><a href="#cb8-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-23"><a href="#cb8-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-24"><a href="#cb8-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>    )</span>
+<span id="cb8-29"><a href="#cb8-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb8-37"><a href="#cb8-37"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb8-44"><a href="#cb8-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb8-48"><a href="#cb8-48"></a>  )</span>
+<span id="cb8-49"><a href="#cb8-49"></a></span>
+<span id="cb8-50"><a href="#cb8-50"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                          A: Drug X                B: Placebo              C: Combination     
+  Dictionary-Derived Term                                      WHITE      NON-WHITE      WHITE      NON-WHITE      WHITE      NON-WHITE 
+                                                               (N=27)      (N=107)       (N=26)      (N=108)       (N=21)      (N=111)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     26 (96.3%)   96 (89.7%)   25 (96.2%)   98 (90.7%)   21 (100%)    99 (89.2%)
+Overall total number of events                                  109          500          144          478          114          589    
+cl A.1                                                                                                                                  
+  Total number of patients with at least one adverse event   16 (59.3%)   62 (57.9%)   21 (80.8%)   54 (50.0%)   15 (71.4%)   74 (66.7%)
+  Total number of events                                         30          102           37           93           25          135    
+  dcd A.1.1.1.1                                              9 (33.3%)    41 (38.3%)   14 (53.8%)   31 (28.7%)   10 (47.6%)   53 (47.7%)
+  dcd A.1.1.1.2                                              11 (40.7%)   37 (34.6%)   13 (50.0%)   35 (32.4%)   9 (42.9%)    41 (36.9%)
+cl B.2                                                                                                                                  
+  Total number of patients with at least one adverse event   15 (55.6%)   64 (59.8%)   16 (61.5%)   58 (53.7%)   12 (57.1%)   73 (65.8%)
+  Total number of events                                         18          111           28          110           17          126    
+  dcd B.2.2.3.1                                              4 (14.8%)    44 (41.1%)   10 (38.5%)   44 (40.7%)   5 (23.8%)    46 (41.4%)
+  dcd B.2.1.2.1                                              12 (44.4%)   37 (34.6%)   9 (34.6%)    35 (32.4%)   7 (33.3%)    45 (40.5%)
+cl D.1                                                                                                                                  
+  Total number of patients with at least one adverse event   18 (66.7%)   61 (57.0%)   15 (57.7%)   52 (48.1%)   14 (66.7%)   66 (59.5%)
+  Total number of events                                         27          100           23           83           27          108    
+  dcd D.1.1.1.1                                              11 (40.7%)   39 (36.4%)   14 (53.8%)   28 (25.9%)   12 (57.1%)   39 (35.1%)
+  dcd D.1.1.4.2                                              11 (40.7%)   37 (34.6%)   7 (26.9%)    35 (32.4%)   9 (42.9%)    41 (36.9%)
+cl D.2                                                                                                                                  
+  Total number of patients with at least one adverse event   6 (22.2%)    41 (38.3%)   15 (57.7%)   43 (39.8%)   9 (42.9%)    48 (43.2%)
+  Total number of events                                         6            56           18           54           12           62    
+  dcd D.2.1.5.3                                              6 (22.2%)    41 (38.3%)   15 (57.7%)   43 (39.8%)   9 (42.9%)    48 (43.2%)
+cl B.1                                                                                                                                  
+  Total number of patients with at least one adverse event   12 (44.4%)   35 (32.7%)   7 (26.9%)    42 (38.9%)   6 (28.6%)    37 (33.3%)
+  Total number of events                                         15           41           8            52           8            54    
+  dcd B.1.1.1.1                                              12 (44.4%)   35 (32.7%)   7 (26.9%)    42 (38.9%)   6 (28.6%)    37 (33.3%)
+cl C.2                                                                                                                                  
+  Total number of patients with at least one adverse event   5 (18.5%)    30 (28.0%)   11 (42.3%)   37 (34.3%)   11 (52.4%)   44 (39.6%)
+  Total number of events                                         8            40           12           41           12           53    
+  dcd C.2.1.2.1                                              5 (18.5%)    30 (28.0%)   11 (42.3%)   37 (34.3%)   11 (52.4%)   44 (39.6%)
+cl C.1                                                                                                                                  
+  Total number of patients with at least one adverse event   5 (18.5%)    38 (35.5%)   13 (50.0%)   33 (30.6%)   8 (38.1%)    35 (31.5%)
+  Total number of events                                         5            50           18           45           13           51    
+  dcd C.1.1.1.3                                              5 (18.5%)    38 (35.5%)   13 (50.0%)   33 (30.6%)   8 (38.1%)    35 (31.5%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="aet06_cache/html/variant5_0d48147fa08c93ebca11b70083ded391">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-6"><a href="#cb10-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb10-7"><a href="#cb10-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-8"><a href="#cb10-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb10-9"><a href="#cb10-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-10"><a href="#cb10-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb10-11"><a href="#cb10-11"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a>    )</span>
+<span id="cb10-13"><a href="#cb10-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb10-16"><a href="#cb10-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-19"><a href="#cb10-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-20"><a href="#cb10-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb10-23"><a href="#cb10-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-24"><a href="#cb10-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-26"><a href="#cb10-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb10-27"><a href="#cb10-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>    )</span>
+<span id="cb10-29"><a href="#cb10-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb10-37"><a href="#cb10-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb10-39"><a href="#cb10-39"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>    )</span>
+<span id="cb10-45"><a href="#cb10-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">count_occurrences</span>(<span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 2L)</span>
+<span id="cb10-48"><a href="#cb10-48"></a></span>
+<span id="cb10-49"><a href="#cb10-49"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-53"><a href="#cb10-53"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class, High-Level Term and Preferred Term.</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-57"><a href="#cb10-57"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb10-59"><a href="#cb10-59"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb10-63"><a href="#cb10-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-65"><a href="#cb10-65"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb10-66"><a href="#cb10-66"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb10-67"><a href="#cb10-67"></a>  )</span>
+<span id="cb10-68"><a href="#cb10-68"></a></span>
+<span id="cb10-69"><a href="#cb10-69"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                            A: Drug X                B: Placebo              C: Combination     
+  High Level Term                                                  F            M            F            M            F            M     
+    Dictionary-Derived Term                                      (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event       72 (91.1%)   50 (90.9%)   77 (93.9%)   46 (88.5%)   65 (92.9%)   55 (88.7%)
+Overall total number of events                                    377          232          419          203          378          325    
+cl A.1                                                                                                                                    
+  Total number of patients with at least one adverse event     53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)
+  Total number of events                                           85           47           93           37           86           74    
+  hlt A.1.1.1                                                                                                                             
+    Total number of patients with at least one adverse event   53 (67.1%)   25 (45.5%)   51 (62.2%)   24 (46.2%)   43 (61.4%)   46 (74.2%)
+    Total number of events                                         85           47           93           37           86           74    
+    dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)
+    dcd A.1.1.1.2                                              32 (40.5%)   16 (29.1%)   33 (40.2%)   15 (28.8%)   24 (34.3%)   26 (41.9%)
+cl B.2                                                                                                                                    
+  Total number of patients with at least one adverse event     46 (58.2%)   33 (60.0%)   45 (54.9%)   29 (55.8%)   44 (62.9%)   41 (66.1%)
+  Total number of events                                           81           48           86           52           64           79    
+  hlt B.2.2.3                                                                                                                             
+    Total number of patients with at least one adverse event   30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)
+    Total number of events                                         40           24           43           33           37           40    
+    dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)
+  hlt B.2.1.2                                                                                                                             
+    Total number of patients with at least one adverse event   29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)
+    Total number of events                                         41           24           43           19           27           39    
+    dcd B.2.1.2.1                                              29 (36.7%)   20 (36.4%)   30 (36.6%)   14 (26.9%)   22 (31.4%)   30 (48.4%)
+cl D.1                                                                                                                                    
+  Total number of patients with at least one adverse event     45 (57.0%)   34 (61.8%)   40 (48.8%)   27 (51.9%)   41 (58.6%)   39 (62.9%)
+  Total number of events                                           72           55           64           42           73           62    
+  hlt D.1.1.1                                                                                                                             
+    Total number of patients with at least one adverse event   25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)
+    Total number of events                                         32           29           36           15           39           32    
+    dcd D.1.1.1.1                                              25 (31.6%)   25 (45.5%)   29 (35.4%)   13 (25.0%)   27 (38.6%)   24 (38.7%)
+  hlt D.1.1.4                                                                                                                             
+    Total number of patients with at least one adverse event   30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)
+    Total number of events                                         40           26           28           27           34           30    
+    dcd D.1.1.4.2                                              30 (38.0%)   18 (32.7%)   22 (26.8%)   20 (38.5%)   27 (38.6%)   23 (37.1%)
+cl D.2                                                                                                                                    
+  Total number of patients with at least one adverse event     26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+  Total number of events                                           35           27           49           23           43           31    
+  hlt D.2.1.5                                                                                                                             
+    Total number of patients with at least one adverse event   26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+    Total number of events                                         35           27           49           23           43           31    
+    dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+cl B.1                                                                                                                                    
+  Total number of patients with at least one adverse event     28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)
+  Total number of events                                           33           23           36           24           35           27    
+  hlt B.1.1.1                                                                                                                             
+    Total number of patients with at least one adverse event   28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)
+    Total number of events                                         33           23           36           24           35           27    
+    dcd B.1.1.1.1                                              28 (35.4%)   19 (34.5%)   33 (40.2%)   16 (30.8%)   24 (34.3%)   19 (30.6%)
+cl C.2                                                                                                                                    
+  Total number of patients with at least one adverse event     23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)
+  Total number of events                                           32           16           39           14           33           32    
+  hlt C.2.1.2                                                                                                                             
+    Total number of patients with at least one adverse event   23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)
+    Total number of events                                         32           16           39           14           33           32    
+    dcd C.2.1.2.1                                              23 (29.1%)   12 (21.8%)   36 (43.9%)   12 (23.1%)   30 (42.9%)   25 (40.3%)
+cl C.1                                                                                                                                    
+  Total number of patients with at least one adverse event     30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)
+  Total number of events                                           39           16           52           11           44           20    
+  hlt C.1.1.1                                                                                                                             
+    Total number of patients with at least one adverse event   30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)
+    Total number of events                                         39           16           52           11           44           20    
+    dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet06_cache/html/teal_e852ab23d70959782b62d0e7c42eebaf">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-4"><a href="#cb12-4"></a></span>
+<span id="cb12-5"><a href="#cb12-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-6"><a href="#cb12-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-9"><a href="#cb12-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-10"><a href="#cb12-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-11"><a href="#cb12-11"></a></span>
+<span id="cb12-12"><a href="#cb12-12"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb12-13"><a href="#cb12-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb12-15"><a href="#cb12-15"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb12-16"><a href="#cb12-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a>  ),</span>
+<span id="cb12-18"><a href="#cb12-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-19"><a href="#cb12-19"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb12-20"><a href="#cb12-20"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb12-21"><a href="#cb12-21"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-22"><a href="#cb12-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"SEX"</span>), <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb12-23"><a href="#cb12-23"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-24"><a href="#cb12-24"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb12-25"><a href="#cb12-25"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-26"><a href="#cb12-26"></a>      ),</span>
+<span id="cb12-27"><a href="#cb12-27"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-28"><a href="#cb12-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb12-29"><a href="#cb12-29"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>      ),</span>
+<span id="cb12-31"><a href="#cb12-31"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-32"><a href="#cb12-32"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>    )</span>
+<span id="cb12-34"><a href="#cb12-34"></a>  )</span>
+<span id="cb12-35"><a href="#cb12-35"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:18:21.1444 pid:10703 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet06_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet06_cache/html/sessioninfo_7e5aea01e72fbef3db360c4e26ccc598">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet06_cache/html/snapshot_168c553936a4faf7a1897935ce9a1b83">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-2"><a href="#cb17-2"></a></span>
+<span id="cb17-3"><a href="#cb17-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb17-4"><a href="#cb17-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb17-5"><a href="#cb17-5"></a></span>
+<span id="cb17-6"><a href="#cb17-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb17-7"><a href="#cb17-7"></a></span>
+<span id="cb17-8"><a href="#cb17-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb17-10"><a href="#cb17-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet06.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+        citeInfo.cites.forEach(function(cite) {
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+        });
+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+<div class="sourceCode" id="cb18" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb18-1"><a href="#cb18-1"></a><span class="co">---</span></span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="an">title:</span><span class="co"> AET06</span></span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events by Baseline Characteristic</span></span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="co">---</span></span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>------------------------------------------------------------------------</span>
+<span id="cb18-7"><a href="#cb18-7"></a></span>
+<span id="cb18-8"><a href="#cb18-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb18-9"><a href="#cb18-9"></a></span>
+<span id="cb18-10"><a href="#cb18-10"></a>::: panel-tabset</span>
+<span id="cb18-11"><a href="#cb18-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb18-12"><a href="#cb18-12"></a></span>
+<span id="cb18-13"><a href="#cb18-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb18-14"><a href="#cb18-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb18-15"><a href="#cb18-15"></a></span>
+<span id="cb18-16"><a href="#cb18-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-17"><a href="#cb18-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb18-18"><a href="#cb18-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-19"><a href="#cb18-19"></a></span>
+<span id="cb18-20"><a href="#cb18-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-21"><a href="#cb18-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb18-22"><a href="#cb18-22"></a>adsub <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsub"</span>)</span>
+<span id="cb18-23"><a href="#cb18-23"></a></span>
+<span id="cb18-24"><a href="#cb18-24"></a>adsub_bmi <span class="ot">&lt;-</span> adsub <span class="sc">%&gt;%</span></span>
+<span id="cb18-25"><a href="#cb18-25"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"BBMISI"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-26"><a href="#cb18-26"></a>  <span class="fu">select</span>(STUDYID, USUBJID, AVALCAT1) <span class="sc">%&gt;%</span></span>
+<span id="cb18-27"><a href="#cb18-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-28"><a href="#cb18-28"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(AVALCAT1, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt;18.5"</span>, <span class="st">"18.5 - 24.9"</span>, <span class="st">"25 - 29.9"</span>, <span class="st">"&gt;30"</span>))</span>
+<span id="cb18-29"><a href="#cb18-29"></a>  )</span>
+<span id="cb18-30"><a href="#cb18-30"></a></span>
+<span id="cb18-31"><a href="#cb18-31"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb18-32"><a href="#cb18-32"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-33"><a href="#cb18-33"></a>    <span class="at">RACE1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-34"><a href="#cb18-34"></a>      RACE <span class="sc">==</span> <span class="st">"WHITE"</span> <span class="sc">~</span> <span class="st">"WHITE"</span>,</span>
+<span id="cb18-35"><a href="#cb18-35"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NON-WHITE"</span></span>
+<span id="cb18-36"><a href="#cb18-36"></a>    ),</span>
+<span id="cb18-37"><a href="#cb18-37"></a>    <span class="at">RACE1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb18-38"><a href="#cb18-38"></a>      RACE1,</span>
+<span id="cb18-39"><a href="#cb18-39"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"WHITE"</span>, <span class="st">"NON-WHITE"</span>)</span>
+<span id="cb18-40"><a href="#cb18-40"></a>    )</span>
+<span id="cb18-41"><a href="#cb18-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-42"><a href="#cb18-42"></a>  <span class="fu">left_join</span>(</span>
+<span id="cb18-43"><a href="#cb18-43"></a>    <span class="at">y =</span> adsub_bmi,</span>
+<span id="cb18-44"><a href="#cb18-44"></a>    <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb18-45"><a href="#cb18-45"></a>  )</span>
+<span id="cb18-46"><a href="#cb18-46"></a></span>
+<span id="cb18-47"><a href="#cb18-47"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb18-48"><a href="#cb18-48"></a></span>
+<span id="cb18-49"><a href="#cb18-49"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb18-50"><a href="#cb18-50"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-51"><a href="#cb18-51"></a>    <span class="at">RACE1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-52"><a href="#cb18-52"></a>      RACE <span class="sc">==</span> <span class="st">"WHITE"</span> <span class="sc">~</span> <span class="st">"WHITE"</span>,</span>
+<span id="cb18-53"><a href="#cb18-53"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NON-WHITE"</span></span>
+<span id="cb18-54"><a href="#cb18-54"></a>    ),</span>
+<span id="cb18-55"><a href="#cb18-55"></a>    <span class="at">RACE1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb18-56"><a href="#cb18-56"></a>      RACE1,</span>
+<span id="cb18-57"><a href="#cb18-57"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"WHITE"</span>, <span class="st">"NON-WHITE"</span>)</span>
+<span id="cb18-58"><a href="#cb18-58"></a>    )</span>
+<span id="cb18-59"><a href="#cb18-59"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-60"><a href="#cb18-60"></a>  <span class="fu">left_join</span>(</span>
+<span id="cb18-61"><a href="#cb18-61"></a>    <span class="at">y =</span> adsub_bmi,</span>
+<span id="cb18-62"><a href="#cb18-62"></a>    <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb18-63"><a href="#cb18-63"></a>  )</span>
+<span id="cb18-64"><a href="#cb18-64"></a></span>
+<span id="cb18-65"><a href="#cb18-65"></a><span class="fu">var_labels</span>(adae) <span class="ot">&lt;-</span> <span class="fu">c</span>(adae_labels, <span class="st">"RACE1"</span> <span class="ot">=</span> <span class="st">"RACE WHITE/NON-WHITE"</span>, <span class="st">"AVALCAT1"</span> <span class="ot">=</span> <span class="st">"Baseline BMI Category"</span>)</span>
+<span id="cb18-66"><a href="#cb18-66"></a></span>
+<span id="cb18-67"><a href="#cb18-67"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb18-68"><a href="#cb18-68"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb18-69"><a href="#cb18-69"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb18-70"><a href="#cb18-70"></a>adsub_bmi <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsub_bmi)</span>
+<span id="cb18-71"><a href="#cb18-71"></a><span class="in">```</span></span>
+<span id="cb18-72"><a href="#cb18-72"></a></span>
+<span id="cb18-73"><a href="#cb18-73"></a><span class="fu">## Adverse Events by Sex</span></span>
+<span id="cb18-74"><a href="#cb18-74"></a></span>
+<span id="cb18-75"><a href="#cb18-75"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb18-76"><a href="#cb18-76"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-77"><a href="#cb18-77"></a></span>
+<span id="cb18-78"><a href="#cb18-78"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-79"><a href="#cb18-79"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-80"><a href="#cb18-80"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-81"><a href="#cb18-81"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb18-82"><a href="#cb18-82"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-83"><a href="#cb18-83"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-84"><a href="#cb18-84"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-85"><a href="#cb18-85"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-86"><a href="#cb18-86"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb18-87"><a href="#cb18-87"></a>    )</span>
+<span id="cb18-88"><a href="#cb18-88"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-89"><a href="#cb18-89"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-90"><a href="#cb18-90"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb18-91"><a href="#cb18-91"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-92"><a href="#cb18-92"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb18-93"><a href="#cb18-93"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-94"><a href="#cb18-94"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-95"><a href="#cb18-95"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb18-96"><a href="#cb18-96"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-97"><a href="#cb18-97"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-98"><a href="#cb18-98"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-99"><a href="#cb18-99"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-100"><a href="#cb18-100"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-101"><a href="#cb18-101"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-102"><a href="#cb18-102"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-103"><a href="#cb18-103"></a>    )</span>
+<span id="cb18-104"><a href="#cb18-104"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-105"><a href="#cb18-105"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-106"><a href="#cb18-106"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb18-107"><a href="#cb18-107"></a></span>
+<span id="cb18-108"><a href="#cb18-108"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb18-109"><a href="#cb18-109"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb18-110"><a href="#cb18-110"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb18-111"><a href="#cb18-111"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb18-112"><a href="#cb18-112"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-113"><a href="#cb18-113"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-114"><a href="#cb18-114"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb18-115"><a href="#cb18-115"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-116"><a href="#cb18-116"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb18-117"><a href="#cb18-117"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-118"><a href="#cb18-118"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-119"><a href="#cb18-119"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-120"><a href="#cb18-120"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb18-121"><a href="#cb18-121"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb18-122"><a href="#cb18-122"></a>  )</span>
+<span id="cb18-123"><a href="#cb18-123"></a></span>
+<span id="cb18-124"><a href="#cb18-124"></a>result</span>
+<span id="cb18-125"><a href="#cb18-125"></a><span class="in">```</span></span>
+<span id="cb18-126"><a href="#cb18-126"></a></span>
+<span id="cb18-127"><a href="#cb18-127"></a><span class="fu">## Adverse Events by Other Baseline &lt;br/&gt; Characteristics (e.g. Biomarker Group)</span></span>
+<span id="cb18-128"><a href="#cb18-128"></a></span>
+<span id="cb18-129"><a href="#cb18-129"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb18-130"><a href="#cb18-130"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-131"><a href="#cb18-131"></a></span>
+<span id="cb18-132"><a href="#cb18-132"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-133"><a href="#cb18-133"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-134"><a href="#cb18-134"></a>  <span class="fu">split_cols_by</span>(<span class="st">"BMRKR2"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-135"><a href="#cb18-135"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb18-136"><a href="#cb18-136"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-137"><a href="#cb18-137"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-138"><a href="#cb18-138"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-139"><a href="#cb18-139"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-140"><a href="#cb18-140"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb18-141"><a href="#cb18-141"></a>    )</span>
+<span id="cb18-142"><a href="#cb18-142"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-143"><a href="#cb18-143"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-144"><a href="#cb18-144"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb18-145"><a href="#cb18-145"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-146"><a href="#cb18-146"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb18-147"><a href="#cb18-147"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-148"><a href="#cb18-148"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-149"><a href="#cb18-149"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb18-150"><a href="#cb18-150"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-151"><a href="#cb18-151"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-152"><a href="#cb18-152"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-153"><a href="#cb18-153"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-154"><a href="#cb18-154"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-155"><a href="#cb18-155"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-156"><a href="#cb18-156"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-157"><a href="#cb18-157"></a>    )</span>
+<span id="cb18-158"><a href="#cb18-158"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-159"><a href="#cb18-159"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-160"><a href="#cb18-160"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb18-161"><a href="#cb18-161"></a></span>
+<span id="cb18-162"><a href="#cb18-162"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb18-163"><a href="#cb18-163"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb18-164"><a href="#cb18-164"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb18-165"><a href="#cb18-165"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb18-166"><a href="#cb18-166"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-167"><a href="#cb18-167"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-168"><a href="#cb18-168"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb18-169"><a href="#cb18-169"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-170"><a href="#cb18-170"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb18-171"><a href="#cb18-171"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-172"><a href="#cb18-172"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-173"><a href="#cb18-173"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-174"><a href="#cb18-174"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb18-175"><a href="#cb18-175"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb18-176"><a href="#cb18-176"></a>  )</span>
+<span id="cb18-177"><a href="#cb18-177"></a></span>
+<span id="cb18-178"><a href="#cb18-178"></a>result</span>
+<span id="cb18-179"><a href="#cb18-179"></a><span class="in">```</span></span>
+<span id="cb18-180"><a href="#cb18-180"></a></span>
+<span id="cb18-181"><a href="#cb18-181"></a><span class="fu">## Adverse Events by Baseline Characteristic &lt;br/&gt; from ADSUB (e.g. BMI Category)</span></span>
+<span id="cb18-182"><a href="#cb18-182"></a></span>
+<span id="cb18-183"><a href="#cb18-183"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb18-184"><a href="#cb18-184"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-185"><a href="#cb18-185"></a></span>
+<span id="cb18-186"><a href="#cb18-186"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-187"><a href="#cb18-187"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-188"><a href="#cb18-188"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVALCAT1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-189"><a href="#cb18-189"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb18-190"><a href="#cb18-190"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-191"><a href="#cb18-191"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-192"><a href="#cb18-192"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-193"><a href="#cb18-193"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-194"><a href="#cb18-194"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb18-195"><a href="#cb18-195"></a>    )</span>
+<span id="cb18-196"><a href="#cb18-196"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-197"><a href="#cb18-197"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-198"><a href="#cb18-198"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb18-199"><a href="#cb18-199"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-200"><a href="#cb18-200"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb18-201"><a href="#cb18-201"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-202"><a href="#cb18-202"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-203"><a href="#cb18-203"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb18-204"><a href="#cb18-204"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-205"><a href="#cb18-205"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-206"><a href="#cb18-206"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-207"><a href="#cb18-207"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-208"><a href="#cb18-208"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-209"><a href="#cb18-209"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-210"><a href="#cb18-210"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-211"><a href="#cb18-211"></a>    )</span>
+<span id="cb18-212"><a href="#cb18-212"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-213"><a href="#cb18-213"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-214"><a href="#cb18-214"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb18-215"><a href="#cb18-215"></a></span>
+<span id="cb18-216"><a href="#cb18-216"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb18-217"><a href="#cb18-217"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb18-218"><a href="#cb18-218"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb18-219"><a href="#cb18-219"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb18-220"><a href="#cb18-220"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-221"><a href="#cb18-221"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-222"><a href="#cb18-222"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb18-223"><a href="#cb18-223"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-224"><a href="#cb18-224"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb18-225"><a href="#cb18-225"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-226"><a href="#cb18-226"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-227"><a href="#cb18-227"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-228"><a href="#cb18-228"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb18-229"><a href="#cb18-229"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb18-230"><a href="#cb18-230"></a>  )</span>
+<span id="cb18-231"><a href="#cb18-231"></a></span>
+<span id="cb18-232"><a href="#cb18-232"></a>result</span>
+<span id="cb18-233"><a href="#cb18-233"></a><span class="in">```</span></span>
+<span id="cb18-234"><a href="#cb18-234"></a></span>
+<span id="cb18-235"><a href="#cb18-235"></a><span class="fu">## Adverse Events by Regrouped Baseline &lt;br/&gt; Characteristics (e.g. Race)</span></span>
+<span id="cb18-236"><a href="#cb18-236"></a></span>
+<span id="cb18-237"><a href="#cb18-237"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb18-238"><a href="#cb18-238"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-239"><a href="#cb18-239"></a></span>
+<span id="cb18-240"><a href="#cb18-240"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-241"><a href="#cb18-241"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-242"><a href="#cb18-242"></a>  <span class="fu">split_cols_by</span>(<span class="st">"RACE1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-243"><a href="#cb18-243"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb18-244"><a href="#cb18-244"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-245"><a href="#cb18-245"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-246"><a href="#cb18-246"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-247"><a href="#cb18-247"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-248"><a href="#cb18-248"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb18-249"><a href="#cb18-249"></a>    )</span>
+<span id="cb18-250"><a href="#cb18-250"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-251"><a href="#cb18-251"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-252"><a href="#cb18-252"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb18-253"><a href="#cb18-253"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-254"><a href="#cb18-254"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb18-255"><a href="#cb18-255"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-256"><a href="#cb18-256"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-257"><a href="#cb18-257"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb18-258"><a href="#cb18-258"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-259"><a href="#cb18-259"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-260"><a href="#cb18-260"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-261"><a href="#cb18-261"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-262"><a href="#cb18-262"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-263"><a href="#cb18-263"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-264"><a href="#cb18-264"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-265"><a href="#cb18-265"></a>    )</span>
+<span id="cb18-266"><a href="#cb18-266"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-267"><a href="#cb18-267"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-268"><a href="#cb18-268"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb18-269"><a href="#cb18-269"></a></span>
+<span id="cb18-270"><a href="#cb18-270"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb18-271"><a href="#cb18-271"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb18-272"><a href="#cb18-272"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb18-273"><a href="#cb18-273"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb18-274"><a href="#cb18-274"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-275"><a href="#cb18-275"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-276"><a href="#cb18-276"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-277"><a href="#cb18-277"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class and Preferred Term.</span></span>
+<span id="cb18-278"><a href="#cb18-278"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-279"><a href="#cb18-279"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb18-280"><a href="#cb18-280"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-281"><a href="#cb18-281"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-282"><a href="#cb18-282"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-283"><a href="#cb18-283"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb18-284"><a href="#cb18-284"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb18-285"><a href="#cb18-285"></a>  )</span>
+<span id="cb18-286"><a href="#cb18-286"></a></span>
+<span id="cb18-287"><a href="#cb18-287"></a>result</span>
+<span id="cb18-288"><a href="#cb18-288"></a><span class="in">```</span></span>
+<span id="cb18-289"><a href="#cb18-289"></a></span>
+<span id="cb18-290"><a href="#cb18-290"></a><span class="fu">## Adverse Events by Baseline Characteristics &lt;br/&gt; (e.g. Sex) Including High-Level Terms</span></span>
+<span id="cb18-291"><a href="#cb18-291"></a></span>
+<span id="cb18-292"><a href="#cb18-292"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb18-293"><a href="#cb18-293"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-294"><a href="#cb18-294"></a></span>
+<span id="cb18-295"><a href="#cb18-295"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-296"><a href="#cb18-296"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-297"><a href="#cb18-297"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-298"><a href="#cb18-298"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb18-299"><a href="#cb18-299"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-300"><a href="#cb18-300"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-301"><a href="#cb18-301"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-302"><a href="#cb18-302"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-303"><a href="#cb18-303"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events"</span></span>
+<span id="cb18-304"><a href="#cb18-304"></a>    )</span>
+<span id="cb18-305"><a href="#cb18-305"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-306"><a href="#cb18-306"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-307"><a href="#cb18-307"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb18-308"><a href="#cb18-308"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-309"><a href="#cb18-309"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb18-310"><a href="#cb18-310"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-311"><a href="#cb18-311"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-312"><a href="#cb18-312"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb18-313"><a href="#cb18-313"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-314"><a href="#cb18-314"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-315"><a href="#cb18-315"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-316"><a href="#cb18-316"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-317"><a href="#cb18-317"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-318"><a href="#cb18-318"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-319"><a href="#cb18-319"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-320"><a href="#cb18-320"></a>    )</span>
+<span id="cb18-321"><a href="#cb18-321"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-322"><a href="#cb18-322"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-323"><a href="#cb18-323"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb18-324"><a href="#cb18-324"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb18-325"><a href="#cb18-325"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb18-326"><a href="#cb18-326"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb18-327"><a href="#cb18-327"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-328"><a href="#cb18-328"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae<span class="sc">$</span>AEHLT)</span>
+<span id="cb18-329"><a href="#cb18-329"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-330"><a href="#cb18-330"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb18-331"><a href="#cb18-331"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb18-332"><a href="#cb18-332"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb18-333"><a href="#cb18-333"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-334"><a href="#cb18-334"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb18-335"><a href="#cb18-335"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb18-336"><a href="#cb18-336"></a>    )</span>
+<span id="cb18-337"><a href="#cb18-337"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-338"><a href="#cb18-338"></a>  <span class="fu">count_occurrences</span>(<span class="st">"AEDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-339"><a href="#cb18-339"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 2L)</span>
+<span id="cb18-340"><a href="#cb18-340"></a></span>
+<span id="cb18-341"><a href="#cb18-341"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb18-342"><a href="#cb18-342"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb18-343"><a href="#cb18-343"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb18-344"><a href="#cb18-344"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb18-345"><a href="#cb18-345"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-346"><a href="#cb18-346"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb18-347"><a href="#cb18-347"></a>  <span class="co"># Sorted by decreasing frequency across all groups by System Organ Class, High-Level Term and Preferred Term.</span></span>
+<span id="cb18-348"><a href="#cb18-348"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-349"><a href="#cb18-349"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb18-350"><a href="#cb18-350"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-351"><a href="#cb18-351"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-352"><a href="#cb18-352"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-353"><a href="#cb18-353"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb18-354"><a href="#cb18-354"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb18-355"><a href="#cb18-355"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-356"><a href="#cb18-356"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb18-357"><a href="#cb18-357"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb18-358"><a href="#cb18-358"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb18-359"><a href="#cb18-359"></a>  )</span>
+<span id="cb18-360"><a href="#cb18-360"></a></span>
+<span id="cb18-361"><a href="#cb18-361"></a>result</span>
+<span id="cb18-362"><a href="#cb18-362"></a><span class="in">```</span></span>
+<span id="cb18-363"><a href="#cb18-363"></a></span>
+<span id="cb18-364"><a href="#cb18-364"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb18-365"><a href="#cb18-365"></a></span>
+<span id="cb18-366"><a href="#cb18-366"></a><span class="fu">## `teal` App</span></span>
+<span id="cb18-367"><a href="#cb18-367"></a></span>
+<span id="cb18-368"><a href="#cb18-368"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb18-369"><a href="#cb18-369"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb18-370"><a href="#cb18-370"></a></span>
+<span id="cb18-371"><a href="#cb18-371"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb18-372"><a href="#cb18-372"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-373"><a href="#cb18-373"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-374"><a href="#cb18-374"></a></span>
+<span id="cb18-375"><a href="#cb18-375"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-376"><a href="#cb18-376"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb18-377"><a href="#cb18-377"></a></span>
+<span id="cb18-378"><a href="#cb18-378"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb18-379"><a href="#cb18-379"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb18-380"><a href="#cb18-380"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb18-381"><a href="#cb18-381"></a></span>
+<span id="cb18-382"><a href="#cb18-382"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb18-383"><a href="#cb18-383"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb18-384"><a href="#cb18-384"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb18-385"><a href="#cb18-385"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb18-386"><a href="#cb18-386"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-387"><a href="#cb18-387"></a>  ),</span>
+<span id="cb18-388"><a href="#cb18-388"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb18-389"><a href="#cb18-389"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb18-390"><a href="#cb18-390"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb18-391"><a href="#cb18-391"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb18-392"><a href="#cb18-392"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"SEX"</span>), <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb18-393"><a href="#cb18-393"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-394"><a href="#cb18-394"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb18-395"><a href="#cb18-395"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb18-396"><a href="#cb18-396"></a>      ),</span>
+<span id="cb18-397"><a href="#cb18-397"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-398"><a href="#cb18-398"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb18-399"><a href="#cb18-399"></a>        <span class="at">selected =</span> <span class="st">"AEBODSYS"</span></span>
+<span id="cb18-400"><a href="#cb18-400"></a>      ),</span>
+<span id="cb18-401"><a href="#cb18-401"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-402"><a href="#cb18-402"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb18-403"><a href="#cb18-403"></a>    )</span>
+<span id="cb18-404"><a href="#cb18-404"></a>  )</span>
+<span id="cb18-405"><a href="#cb18-405"></a>)</span>
+<span id="cb18-406"><a href="#cb18-406"></a></span>
+<span id="cb18-407"><a href="#cb18-407"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb18-408"><a href="#cb18-408"></a><span class="in">```</span></span>
+<span id="cb18-409"><a href="#cb18-409"></a></span>
+<span id="cb18-410"><a href="#cb18-410"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb18-411"><a href="#cb18-411"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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diff --git a/stable/tables/adverse-events/aet06_smq.html b/stable/tables/adverse-events/aet06_smq.html
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+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
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+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
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+          <li class="sidebar-item">
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+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+<div class="quarto-title-block"><div><h1 class="title">AET06_SMQ</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events by Baseline Characteristic, by SMQ and Preferred Term</p>
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+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Adverse Events by Sex, <br> by SMQ and Preferred Term</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Adverse Events by Sex, by SMQ and <br> Preferred Term (with Customized Queries)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Adverse Events by Other Baseline <br> Characteristics (e.g.&nbsp;Age Group)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet06_smq_cache/html/setup_e8959ad49ca75b9745ae0f316a4224c8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>    ),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      AGE65,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    )</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  )</span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>    ),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      AGE65,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    )</span>
+<span id="cb1-34"><a href="#cb1-34"></a>  )</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a><span class="co"># levels. For details, refer to Teal and Study Data article.</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-39"><a href="#cb1-39"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-40"><a href="#cb1-40"></a></span>
+<span id="cb1-41"><a href="#cb1-41"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>)</span>
+<span id="cb1-52"><a href="#cb1-52"></a></span>
+<span id="cb1-53"><a href="#cb1-53"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb1-55"><a href="#cb1-55"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-58"><a href="#cb1-58"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-59"><a href="#cb1-59"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb1-61"><a href="#cb1-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-63"><a href="#cb1-63"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb1-64"><a href="#cb1-64"></a></span>
+<span id="cb1-65"><a href="#cb1-65"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb1-66"><a href="#cb1-66"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(</span>
+<span id="cb1-67"><a href="#cb1-67"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb1-68"><a href="#cb1-68"></a>  <span class="at">aag_summary =</span> aag_summary,</span>
+<span id="cb1-69"><a href="#cb1-69"></a>  <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SEX"</span>, <span class="st">"AGE65"</span>)</span>
+<span id="cb1-70"><a href="#cb1-70"></a>)</span>
+<span id="cb1-71"><a href="#cb1-71"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb1-72"><a href="#cb1-72"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb1-73"><a href="#cb1-73"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb1-74"><a href="#cb1-74"></a></span>
+<span id="cb1-75"><a href="#cb1-75"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb1-76"><a href="#cb1-76"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb1-77"><a href="#cb1-77"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb1-78"><a href="#cb1-78"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-79"><a href="#cb1-79"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb1-80"><a href="#cb1-80"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet06_smq_cache/html/variant1_9b33022a9f396a984f04f8eede30839b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>    )</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">append_varlabels</span>(adae_smq_1, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-29"><a href="#cb2-29"></a></span>
+<span id="cb2-30"><a href="#cb2-30"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-34"><a href="#cb2-34"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-38"><a href="#cb2-38"></a></span>
+<span id="cb2-39"><a href="#cb2-39"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                             ARM A                     ARM B                     ARM C         
+  Dictionary-Derived Term                                        F            M            F            M            F            M     
+                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                                         
+  Total number of patients with at least one adverse event   47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)
+  Total number of events                                         79           40           95           44           81           60    
+    dcd B.2.2.3.1                                            30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)
+    dcd C.1.1.1.3                                            30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet06_smq_cache/html/variant2_a24be34584d7e75d89324d2b7f50de96">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb4-3"><a href="#cb4-3"></a>}</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>    ),</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">append_varlabels</span>(adae_smq_all, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-32"><a href="#cb4-32"></a></span>
+<span id="cb4-33"><a href="#cb4-33"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb4-36"><a href="#cb4-36"></a>}</span>
+<span id="cb4-37"><a href="#cb4-37"></a></span>
+<span id="cb4-38"><a href="#cb4-38"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-42"><a href="#cb4-42"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-46"><a href="#cb4-46"></a></span>
+<span id="cb4-47"><a href="#cb4-47"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                             ARM A                     ARM B                     ARM C         
+  Dictionary-Derived Term                                        F            M            F            M            F            M     
+                                                               (N=79)       (N=55)       (N=82)       (N=52)       (N=70)       (N=62)  
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     59 (74.7%)   36 (65.5%)   68 (82.9%)   35 (67.3%)   61 (87.1%)   47 (75.8%)
+D.2.1.5.3/A.1.1.1.1 AESI                                                                                                                
+  Total number of patients with at least one adverse event   45 (57.0%)   29 (52.7%)   54 (65.9%)   26 (50.0%)   50 (71.4%)   37 (59.7%)
+  Total number of events                                         78           48           91           43           88           74    
+  dcd D.2.1.5.3                                              26 (32.9%)   21 (38.2%)   40 (48.8%)   18 (34.6%)   34 (48.6%)   23 (37.1%)
+  dcd A.1.1.1.1                                              34 (43.0%)   16 (29.1%)   31 (37.8%)   14 (26.9%)   33 (47.1%)   30 (48.4%)
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                                         
+  Total number of patients with at least one adverse event   47 (59.5%)   25 (45.5%)   51 (62.2%)   28 (53.8%)   42 (60.0%)   33 (53.2%)
+  Total number of events                                         79           40           95           44           81           60    
+  dcd B.2.2.3.1                                              30 (38.0%)   18 (32.7%)   32 (39.0%)   22 (42.3%)   26 (37.1%)   25 (40.3%)
+  dcd C.1.1.1.3                                              30 (38.0%)   13 (23.6%)   36 (43.9%)   10 (19.2%)   27 (38.6%)   16 (25.8%)
+non observed SMQ02NAM level(BROAD)                                                                                                      
+  Total number of patients with at least one adverse event       0            0            0            0            0            0     
+  Total number of events                                         0            0            0            0            0            0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="aet06_smq_cache/html/variant3_9e714516bb41a8c9efaff748d552f333">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AGE65"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>    )</span>
+<span id="cb6-26"><a href="#cb6-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="fu">append_varlabels</span>(adae_smq_1, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb6-29"><a href="#cb6-29"></a></span>
+<span id="cb6-30"><a href="#cb6-30"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb6-32"><a href="#cb6-32"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb6-34"><a href="#cb6-34"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb6-38"><a href="#cb6-38"></a></span>
+<span id="cb6-39"><a href="#cb6-39"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                          ARM A                ARM B                ARM C       
+  Dictionary-Derived Term                                       &lt; 65      &gt;= 65      &lt; 65      &gt;= 65      &lt; 65      &gt;= 65
+                                                              (N=134)     (N=0)    (N=134)     (N=0)    (N=131)     (N=1)
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     72 (53.7%)     0     79 (59.0%)     0     75 (57.3%)     0  
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                                          
+  Total number of patients with at least one adverse event   72 (53.7%)     0     79 (59.0%)     0     75 (57.3%)     0  
+  Total number of events                                        119         0        139         0        141         0  
+    dcd B.2.2.3.1                                            48 (35.8%)     0     54 (40.3%)     0     51 (38.9%)     0  
+    dcd C.1.1.1.3                                            43 (32.1%)     0     46 (34.3%)     0     43 (32.8%)     0  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aet06_smq_cache/html/teal_0df2b59c3c4b379f906241f8b22ff0f1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-4"><a href="#cb8-4"></a></span>
+<span id="cb8-5"><a href="#cb8-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-8"><a href="#cb8-8"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>    ),</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-12"><a href="#cb8-12"></a>      AGE65,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    )</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  )</span>
+<span id="cb8-16"><a href="#cb8-16"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-19"><a href="#cb8-19"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb8-21"><a href="#cb8-21"></a>    ),</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-23"><a href="#cb8-23"></a>      AGE65,</span>
+<span id="cb8-24"><a href="#cb8-24"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    )</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  )</span>
+<span id="cb8-27"><a href="#cb8-27"></a></span>
+<span id="cb8-28"><a href="#cb8-28"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-30"><a href="#cb8-30"></a></span>
+<span id="cb8-31"><a href="#cb8-31"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb8-34"><a href="#cb8-34"></a>)</span>
+<span id="cb8-35"><a href="#cb8-35"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>)</span>
+<span id="cb8-40"><a href="#cb8-40"></a></span>
+<span id="cb8-41"><a href="#cb8-41"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a><span class="st">    mutate(</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a><span class="st">      AGE65 = case_when(</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a><span class="st">        AGE &gt;= 65 ~ "&gt;= 65",</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a><span class="st">        TRUE ~ "&lt; 65"</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a><span class="st">      ),</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a><span class="st">      AGE65 = factor(</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a><span class="st">        AGE65,</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a><span class="st">      levels = c("&lt; 65", "&gt;= 65")</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a><span class="st">        )</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a><span class="st">    )'</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>    ),</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae") %&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a><span class="st">    mutate(</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a><span class="st">      AGE65 = case_when(</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a><span class="st">        AGE &gt;= 65 ~ "&gt;= 65",</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a><span class="st">        TRUE ~ "&lt; 65"</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a><span class="st">      ),</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a><span class="st">      AGE65 = factor(</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a><span class="st">        AGE65,</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a><span class="st">      levels = c("&lt; 65", "&gt;= 65")</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a><span class="st">        )</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a><span class="st">    )'</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>    ),</span>
+<span id="cb8-69"><a href="#cb8-69"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-70"><a href="#cb8-70"></a>  ),</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-72"><a href="#cb8-72"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb8-73"><a href="#cb8-73"></a>      <span class="at">label =</span> <span class="st">"Adverse events by `SMQ` Table"</span>,</span>
+<span id="cb8-74"><a href="#cb8-74"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb8-75"><a href="#cb8-75"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-76"><a href="#cb8-76"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>, <span class="st">"AGE65"</span>)),</span>
+<span id="cb8-77"><a href="#cb8-77"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb8-78"><a href="#cb8-78"></a>      ),</span>
+<span id="cb8-79"><a href="#cb8-79"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb8-82"><a href="#cb8-82"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-83"><a href="#cb8-83"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb8-84"><a href="#cb8-84"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>      )</span>
+<span id="cb8-86"><a href="#cb8-86"></a>    )</span>
+<span id="cb8-87"><a href="#cb8-87"></a>  )</span>
+<span id="cb8-88"><a href="#cb8-88"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:19:56.5276 pid:10998 token:[] teal.modules.clinical Initializing tm_t_smq</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet06_smq_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet06_smq_cache/html/sessioninfo_9846ae92f5d7d468e2711ea1eb42867a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] stringr_1.5.0                scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          
+[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         
+[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      
+[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           
+[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[85] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet06_smq_cache/html/snapshot_ed31c072d8d51ae965259a02041463ac">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet06_smq.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
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+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+    if (styleSentinel !== null) {
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+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
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+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
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+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+      }
+      return codeEl.innerText;
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+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
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+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> AET06_SMQ</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events by Baseline Characteristic, by SMQ and Preferred Term</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb14-20"><a href="#cb14-20"></a></span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb14-23"><a href="#cb14-23"></a></span>
+<span id="cb14-24"><a href="#cb14-24"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb14-25"><a href="#cb14-25"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb14-26"><a href="#cb14-26"></a></span>
+<span id="cb14-27"><a href="#cb14-27"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-28"><a href="#cb14-28"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-29"><a href="#cb14-29"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-30"><a href="#cb14-30"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb14-31"><a href="#cb14-31"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb14-32"><a href="#cb14-32"></a>    ),</span>
+<span id="cb14-33"><a href="#cb14-33"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-34"><a href="#cb14-34"></a>      AGE65,</span>
+<span id="cb14-35"><a href="#cb14-35"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb14-36"><a href="#cb14-36"></a>    )</span>
+<span id="cb14-37"><a href="#cb14-37"></a>  )</span>
+<span id="cb14-38"><a href="#cb14-38"></a></span>
+<span id="cb14-39"><a href="#cb14-39"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-41"><a href="#cb14-41"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-42"><a href="#cb14-42"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb14-43"><a href="#cb14-43"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb14-44"><a href="#cb14-44"></a>    ),</span>
+<span id="cb14-45"><a href="#cb14-45"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-46"><a href="#cb14-46"></a>      AGE65,</span>
+<span id="cb14-47"><a href="#cb14-47"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb14-48"><a href="#cb14-48"></a>    )</span>
+<span id="cb14-49"><a href="#cb14-49"></a>  )</span>
+<span id="cb14-50"><a href="#cb14-50"></a></span>
+<span id="cb14-51"><a href="#cb14-51"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing</span></span>
+<span id="cb14-52"><a href="#cb14-52"></a><span class="co"># levels. For details, refer to Teal and Study Data article.</span></span>
+<span id="cb14-53"><a href="#cb14-53"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-54"><a href="#cb14-54"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb14-55"><a href="#cb14-55"></a></span>
+<span id="cb14-56"><a href="#cb14-56"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb14-58"><a href="#cb14-58"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb14-59"><a href="#cb14-59"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb14-60"><a href="#cb14-60"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb14-61"><a href="#cb14-61"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb14-62"><a href="#cb14-62"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb14-63"><a href="#cb14-63"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb14-64"><a href="#cb14-64"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb14-65"><a href="#cb14-65"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-66"><a href="#cb14-66"></a>)</span>
+<span id="cb14-67"><a href="#cb14-67"></a></span>
+<span id="cb14-68"><a href="#cb14-68"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb14-69"><a href="#cb14-69"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb14-71"><a href="#cb14-71"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb14-72"><a href="#cb14-72"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb14-73"><a href="#cb14-73"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-74"><a href="#cb14-74"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb14-76"><a href="#cb14-76"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb14-78"><a href="#cb14-78"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb14-79"><a href="#cb14-79"></a></span>
+<span id="cb14-80"><a href="#cb14-80"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb14-81"><a href="#cb14-81"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(</span>
+<span id="cb14-82"><a href="#cb14-82"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb14-83"><a href="#cb14-83"></a>  <span class="at">aag_summary =</span> aag_summary,</span>
+<span id="cb14-84"><a href="#cb14-84"></a>  <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SEX"</span>, <span class="st">"AGE65"</span>)</span>
+<span id="cb14-85"><a href="#cb14-85"></a>)</span>
+<span id="cb14-86"><a href="#cb14-86"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb14-87"><a href="#cb14-87"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb14-88"><a href="#cb14-88"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb14-89"><a href="#cb14-89"></a></span>
+<span id="cb14-90"><a href="#cb14-90"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb14-91"><a href="#cb14-91"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb14-92"><a href="#cb14-92"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb14-93"><a href="#cb14-93"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-94"><a href="#cb14-94"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb14-95"><a href="#cb14-95"></a>  )</span>
+<span id="cb14-96"><a href="#cb14-96"></a><span class="in">```</span></span>
+<span id="cb14-97"><a href="#cb14-97"></a></span>
+<span id="cb14-98"><a href="#cb14-98"></a><span class="fu">## Adverse Events by Sex, &lt;br/&gt; by SMQ and Preferred Term</span></span>
+<span id="cb14-99"><a href="#cb14-99"></a></span>
+<span id="cb14-100"><a href="#cb14-100"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb14-101"><a href="#cb14-101"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb14-102"><a href="#cb14-102"></a></span>
+<span id="cb14-103"><a href="#cb14-103"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-104"><a href="#cb14-104"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-105"><a href="#cb14-105"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb14-107"><a href="#cb14-107"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-108"><a href="#cb14-108"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb14-110"><a href="#cb14-110"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-111"><a href="#cb14-111"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb14-112"><a href="#cb14-112"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb14-113"><a href="#cb14-113"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb14-114"><a href="#cb14-114"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-115"><a href="#cb14-115"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-116"><a href="#cb14-116"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb14-117"><a href="#cb14-117"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb14-118"><a href="#cb14-118"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-119"><a href="#cb14-119"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb14-120"><a href="#cb14-120"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-121"><a href="#cb14-121"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb14-122"><a href="#cb14-122"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-123"><a href="#cb14-123"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb14-124"><a href="#cb14-124"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb14-125"><a href="#cb14-125"></a>    )</span>
+<span id="cb14-126"><a href="#cb14-126"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-127"><a href="#cb14-127"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-128"><a href="#cb14-128"></a>  <span class="fu">append_varlabels</span>(adae_smq_1, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb14-129"><a href="#cb14-129"></a></span>
+<span id="cb14-130"><a href="#cb14-130"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb14-131"><a href="#cb14-131"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb14-132"><a href="#cb14-132"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb14-133"><a href="#cb14-133"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb14-134"><a href="#cb14-134"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-135"><a href="#cb14-135"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb14-136"><a href="#cb14-136"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-137"><a href="#cb14-137"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb14-138"><a href="#cb14-138"></a></span>
+<span id="cb14-139"><a href="#cb14-139"></a>result</span>
+<span id="cb14-140"><a href="#cb14-140"></a><span class="in">```</span></span>
+<span id="cb14-141"><a href="#cb14-141"></a></span>
+<span id="cb14-142"><a href="#cb14-142"></a><span class="fu">## Adverse Events by Sex, by SMQ and &lt;br/&gt; Preferred Term (with Customized Queries)</span></span>
+<span id="cb14-143"><a href="#cb14-143"></a></span>
+<span id="cb14-144"><a href="#cb14-144"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb14-145"><a href="#cb14-145"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb14-146"><a href="#cb14-146"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb14-147"><a href="#cb14-147"></a>}</span>
+<span id="cb14-148"><a href="#cb14-148"></a></span>
+<span id="cb14-149"><a href="#cb14-149"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-150"><a href="#cb14-150"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-151"><a href="#cb14-151"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-152"><a href="#cb14-152"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb14-153"><a href="#cb14-153"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-154"><a href="#cb14-154"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb14-155"><a href="#cb14-155"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb14-156"><a href="#cb14-156"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-157"><a href="#cb14-157"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb14-158"><a href="#cb14-158"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb14-159"><a href="#cb14-159"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb14-160"><a href="#cb14-160"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-161"><a href="#cb14-161"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-162"><a href="#cb14-162"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb14-163"><a href="#cb14-163"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb14-164"><a href="#cb14-164"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-165"><a href="#cb14-165"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb14-166"><a href="#cb14-166"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-167"><a href="#cb14-167"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb14-168"><a href="#cb14-168"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-169"><a href="#cb14-169"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb14-170"><a href="#cb14-170"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb14-171"><a href="#cb14-171"></a>    ),</span>
+<span id="cb14-172"><a href="#cb14-172"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-173"><a href="#cb14-173"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-174"><a href="#cb14-174"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-175"><a href="#cb14-175"></a>  <span class="fu">append_varlabels</span>(adae_smq_all, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb14-176"><a href="#cb14-176"></a></span>
+<span id="cb14-177"><a href="#cb14-177"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb14-178"><a href="#cb14-178"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb14-179"><a href="#cb14-179"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb14-180"><a href="#cb14-180"></a>}</span>
+<span id="cb14-181"><a href="#cb14-181"></a></span>
+<span id="cb14-182"><a href="#cb14-182"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb14-183"><a href="#cb14-183"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb14-184"><a href="#cb14-184"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb14-185"><a href="#cb14-185"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb14-186"><a href="#cb14-186"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-187"><a href="#cb14-187"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb14-188"><a href="#cb14-188"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-189"><a href="#cb14-189"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb14-190"><a href="#cb14-190"></a></span>
+<span id="cb14-191"><a href="#cb14-191"></a>result</span>
+<span id="cb14-192"><a href="#cb14-192"></a><span class="in">```</span></span>
+<span id="cb14-193"><a href="#cb14-193"></a></span>
+<span id="cb14-194"><a href="#cb14-194"></a><span class="fu">## Adverse Events by Other Baseline &lt;br/&gt; Characteristics (e.g. Age Group)</span></span>
+<span id="cb14-195"><a href="#cb14-195"></a></span>
+<span id="cb14-196"><a href="#cb14-196"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb14-197"><a href="#cb14-197"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb14-198"><a href="#cb14-198"></a></span>
+<span id="cb14-199"><a href="#cb14-199"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-200"><a href="#cb14-200"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-201"><a href="#cb14-201"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AGE65"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-202"><a href="#cb14-202"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb14-203"><a href="#cb14-203"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-204"><a href="#cb14-204"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb14-205"><a href="#cb14-205"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>)</span>
+<span id="cb14-206"><a href="#cb14-206"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-207"><a href="#cb14-207"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb14-208"><a href="#cb14-208"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb14-209"><a href="#cb14-209"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb14-210"><a href="#cb14-210"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-211"><a href="#cb14-211"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-212"><a href="#cb14-212"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb14-213"><a href="#cb14-213"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb14-214"><a href="#cb14-214"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-215"><a href="#cb14-215"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb14-216"><a href="#cb14-216"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb14-217"><a href="#cb14-217"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb14-218"><a href="#cb14-218"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-219"><a href="#cb14-219"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb14-220"><a href="#cb14-220"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb14-221"><a href="#cb14-221"></a>    )</span>
+<span id="cb14-222"><a href="#cb14-222"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-223"><a href="#cb14-223"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-224"><a href="#cb14-224"></a>  <span class="fu">append_varlabels</span>(adae_smq_1, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb14-225"><a href="#cb14-225"></a></span>
+<span id="cb14-226"><a href="#cb14-226"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb14-227"><a href="#cb14-227"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb14-228"><a href="#cb14-228"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb14-229"><a href="#cb14-229"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb14-230"><a href="#cb14-230"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-231"><a href="#cb14-231"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb14-232"><a href="#cb14-232"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-233"><a href="#cb14-233"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb14-234"><a href="#cb14-234"></a></span>
+<span id="cb14-235"><a href="#cb14-235"></a>result</span>
+<span id="cb14-236"><a href="#cb14-236"></a><span class="in">```</span></span>
+<span id="cb14-237"><a href="#cb14-237"></a></span>
+<span id="cb14-238"><a href="#cb14-238"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-239"><a href="#cb14-239"></a></span>
+<span id="cb14-240"><a href="#cb14-240"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-241"><a href="#cb14-241"></a></span>
+<span id="cb14-242"><a href="#cb14-242"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-243"><a href="#cb14-243"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb14-244"><a href="#cb14-244"></a></span>
+<span id="cb14-245"><a href="#cb14-245"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-246"><a href="#cb14-246"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-247"><a href="#cb14-247"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-248"><a href="#cb14-248"></a></span>
+<span id="cb14-249"><a href="#cb14-249"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-250"><a href="#cb14-250"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-251"><a href="#cb14-251"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-252"><a href="#cb14-252"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb14-253"><a href="#cb14-253"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb14-254"><a href="#cb14-254"></a>    ),</span>
+<span id="cb14-255"><a href="#cb14-255"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-256"><a href="#cb14-256"></a>      AGE65,</span>
+<span id="cb14-257"><a href="#cb14-257"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb14-258"><a href="#cb14-258"></a>    )</span>
+<span id="cb14-259"><a href="#cb14-259"></a>  )</span>
+<span id="cb14-260"><a href="#cb14-260"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-261"><a href="#cb14-261"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-262"><a href="#cb14-262"></a>    <span class="at">AGE65 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-263"><a href="#cb14-263"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">65</span> <span class="sc">~</span> <span class="st">"&gt;= 65"</span>,</span>
+<span id="cb14-264"><a href="#cb14-264"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&lt; 65"</span></span>
+<span id="cb14-265"><a href="#cb14-265"></a>    ),</span>
+<span id="cb14-266"><a href="#cb14-266"></a>    <span class="at">AGE65 =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-267"><a href="#cb14-267"></a>      AGE65,</span>
+<span id="cb14-268"><a href="#cb14-268"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 65"</span>, <span class="st">"&gt;= 65"</span>)</span>
+<span id="cb14-269"><a href="#cb14-269"></a>    )</span>
+<span id="cb14-270"><a href="#cb14-270"></a>  )</span>
+<span id="cb14-271"><a href="#cb14-271"></a></span>
+<span id="cb14-272"><a href="#cb14-272"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-273"><a href="#cb14-273"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-274"><a href="#cb14-274"></a></span>
+<span id="cb14-275"><a href="#cb14-275"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-276"><a href="#cb14-276"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb14-277"><a href="#cb14-277"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb14-278"><a href="#cb14-278"></a>)</span>
+<span id="cb14-279"><a href="#cb14-279"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-280"><a href="#cb14-280"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb14-281"><a href="#cb14-281"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb14-282"><a href="#cb14-282"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-283"><a href="#cb14-283"></a>)</span>
+<span id="cb14-284"><a href="#cb14-284"></a></span>
+<span id="cb14-285"><a href="#cb14-285"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-286"><a href="#cb14-286"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-287"><a href="#cb14-287"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb14-288"><a href="#cb14-288"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb14-289"><a href="#cb14-289"></a><span class="st">    mutate(</span></span>
+<span id="cb14-290"><a href="#cb14-290"></a><span class="st">      AGE65 = case_when(</span></span>
+<span id="cb14-291"><a href="#cb14-291"></a><span class="st">        AGE &gt;= 65 ~ "&gt;= 65",</span></span>
+<span id="cb14-292"><a href="#cb14-292"></a><span class="st">        TRUE ~ "&lt; 65"</span></span>
+<span id="cb14-293"><a href="#cb14-293"></a><span class="st">      ),</span></span>
+<span id="cb14-294"><a href="#cb14-294"></a><span class="st">      AGE65 = factor(</span></span>
+<span id="cb14-295"><a href="#cb14-295"></a><span class="st">        AGE65,</span></span>
+<span id="cb14-296"><a href="#cb14-296"></a><span class="st">      levels = c("&lt; 65", "&gt;= 65")</span></span>
+<span id="cb14-297"><a href="#cb14-297"></a><span class="st">        )</span></span>
+<span id="cb14-298"><a href="#cb14-298"></a><span class="st">    )'</span></span>
+<span id="cb14-299"><a href="#cb14-299"></a>    ),</span>
+<span id="cb14-300"><a href="#cb14-300"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb14-301"><a href="#cb14-301"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae") %&gt;%</span></span>
+<span id="cb14-302"><a href="#cb14-302"></a><span class="st">    mutate(</span></span>
+<span id="cb14-303"><a href="#cb14-303"></a><span class="st">      AGE65 = case_when(</span></span>
+<span id="cb14-304"><a href="#cb14-304"></a><span class="st">        AGE &gt;= 65 ~ "&gt;= 65",</span></span>
+<span id="cb14-305"><a href="#cb14-305"></a><span class="st">        TRUE ~ "&lt; 65"</span></span>
+<span id="cb14-306"><a href="#cb14-306"></a><span class="st">      ),</span></span>
+<span id="cb14-307"><a href="#cb14-307"></a><span class="st">      AGE65 = factor(</span></span>
+<span id="cb14-308"><a href="#cb14-308"></a><span class="st">        AGE65,</span></span>
+<span id="cb14-309"><a href="#cb14-309"></a><span class="st">      levels = c("&lt; 65", "&gt;= 65")</span></span>
+<span id="cb14-310"><a href="#cb14-310"></a><span class="st">        )</span></span>
+<span id="cb14-311"><a href="#cb14-311"></a><span class="st">    )'</span></span>
+<span id="cb14-312"><a href="#cb14-312"></a>    ),</span>
+<span id="cb14-313"><a href="#cb14-313"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-314"><a href="#cb14-314"></a>  ),</span>
+<span id="cb14-315"><a href="#cb14-315"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-316"><a href="#cb14-316"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb14-317"><a href="#cb14-317"></a>      <span class="at">label =</span> <span class="st">"Adverse events by `SMQ` Table"</span>,</span>
+<span id="cb14-318"><a href="#cb14-318"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb14-319"><a href="#cb14-319"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-320"><a href="#cb14-320"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>, <span class="st">"AGE65"</span>)),</span>
+<span id="cb14-321"><a href="#cb14-321"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb14-322"><a href="#cb14-322"></a>      ),</span>
+<span id="cb14-323"><a href="#cb14-323"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-324"><a href="#cb14-324"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb14-325"><a href="#cb14-325"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb14-326"><a href="#cb14-326"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-327"><a href="#cb14-327"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb14-328"><a href="#cb14-328"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb14-329"><a href="#cb14-329"></a>      )</span>
+<span id="cb14-330"><a href="#cb14-330"></a>    )</span>
+<span id="cb14-331"><a href="#cb14-331"></a>  )</span>
+<span id="cb14-332"><a href="#cb14-332"></a>)</span>
+<span id="cb14-333"><a href="#cb14-333"></a></span>
+<span id="cb14-334"><a href="#cb14-334"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-335"><a href="#cb14-335"></a><span class="in">```</span></span>
+<span id="cb14-336"><a href="#cb14-336"></a></span>
+<span id="cb14-337"><a href="#cb14-337"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-338"><a href="#cb14-338"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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new file mode 100644
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+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+    "search-more-matches-text": "more matches in this document",
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+    "search-detached-cancel-button-title": "Cancel",
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+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - AET07">
+<meta property="og:description" content="Adverse Events Resulting in Death">
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+  </li>  
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+<div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
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+  <div class="quarto-reader-toggle-btn">
+  <i class="bi"></i>
+  </div>
+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
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+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
+      </button>
+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet01.html">Adverse Events</a></li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet07.html">AET07</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
+      </a>
+    </div>
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+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
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+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET07</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events Resulting in Death</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Fill-In of Treatment Groups without Deaths</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>For illustrative purposes, we will pre-process <code>AESDTH</code> in ADAE so there are no deaths in arm A and concatenate <code>AEBODSYS</code> and <code>AEDECOD</code> as per GDSR output standards for AET07.</p>
+<div class="cell" data-hash="aet07_cache/html/setup_76d90860152ef5fdd2d740a935190e4c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adae_f <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">AESDTH =</span> <span class="fu">as.character</span>(AESDTH), <span class="co"># characterizing AESDTH for next step</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">AESDTH =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span> <span class="sc">~</span> <span class="cn">NA_character_</span>, <span class="co"># For demonstration purpose only,</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> AESDTH</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    ), <span class="co"># make "A: Drug X" as the arm without AE leading to death</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AESDTH =</span> <span class="fu">as.factor</span>(AESDTH),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">SOC_PT =</span> <span class="fu">factor</span>(<span class="fu">paste</span>(AEBODSYS, <span class="st">"/"</span>, AEDECOD))</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(ARM))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet07_cache/html/variant1_1b3a4544d74500a0eb41927ac5f969cc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">vars =</span> <span class="st">"SOC_PT"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-21"><a href="#cb2-21"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">path =</span> <span class="st">"SOC_PT"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  )</span>
+<span id="cb2-28"><a href="#cb2-28"></a></span>
+<span id="cb2-29"><a href="#cb2-29"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA SOC and Preferred Term   B: Placebo   C: Combination
+                                 (N=134)        (N=132)    
+———————————————————————————————————————————————————————————
+Total number of deaths          70 (52.2%)     75 (56.8%)  
+cl D.1 / dcd D.1.1.1.1          42 (31.3%)     51 (38.6%)  
+cl B.1 / dcd B.1.1.1.1          49 (36.6%)     43 (32.6%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet07_cache/html/variant2_5aaa5e67881d2bf641e7a4fc2ac7d8c0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">vars =</span> <span class="st">"SOC_PT"</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-18"><a href="#cb4-18"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">path =</span> <span class="st">"SOC_PT"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  )</span>
+<span id="cb4-25"><a href="#cb4-25"></a></span>
+<span id="cb4-26"><a href="#cb4-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA SOC and Preferred Term   A: Drug X   B: Placebo   C: Combination
+                                 (N=134)     (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————
+Total number of deaths              0       70 (52.2%)     75 (56.8%)  
+cl D.1 / dcd D.1.1.1.1              0       42 (31.3%)     51 (38.6%)  
+cl B.1 / dcd B.1.1.1.1              0       49 (36.6%)     43 (32.6%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="aet07_cache/html/teal_e18a4ae2ea47cd058249e1f1678351d8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="fu">library</span>(tern)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-8"><a href="#cb6-8"></a></span>
+<span id="cb6-9"><a href="#cb6-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">DTHFL =</span> <span class="fu">case_when</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="sc">!</span><span class="fu">is.na</span>(DTHDT) <span class="sc">~</span> <span class="st">"Y"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>    )</span>
+<span id="cb6-19"><a href="#cb6-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">DTHFL =</span> <span class="st">"Subject Death Flag"</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  )</span>
+<span id="cb6-23"><a href="#cb6-23"></a></span>
+<span id="cb6-24"><a href="#cb6-24"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">AESDTH =</span> <span class="fu">as.character</span>(AESDTH), <span class="co"># characterizing AESDTH for next step</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">AESDTH =</span> <span class="fu">case_when</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>      ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span> <span class="sc">~</span> <span class="cn">NA_character_</span>, <span class="co"># For demonstration purpose only,</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> AESDTH</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    ), <span class="co"># make "A: Drug X" as the arm without AE leading to death</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">AESDTH =</span> <span class="fu">as.factor</span>(AESDTH),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">SOC_PT =</span> <span class="fu">factor</span>(<span class="fu">paste</span>(AEBODSYS, <span class="st">"/"</span>, AEDECOD))</span>
+<span id="cb6-33"><a href="#cb6-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>  <span class="fu">filter</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(ARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>  <span class="fu">var_relabel</span>(<span class="at">SOC_PT =</span> <span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb6-37"><a href="#cb6-37"></a></span>
+<span id="cb6-38"><a href="#cb6-38"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a><span class="st">                    df_explicit_na() %&gt;%</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a><span class="st">                    mutate(</span></span>
+<span id="cb6-44"><a href="#cb6-44"></a><span class="st">                      DTHFL = case_when(</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a><span class="st">                        !is.na(DTHDT) ~ "Y",</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a><span class="st">                        TRUE ~ ""</span></span>
+<span id="cb6-47"><a href="#cb6-47"></a><span class="st">                      )</span></span>
+<span id="cb6-48"><a href="#cb6-48"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb6-49"><a href="#cb6-49"></a><span class="st">                    var_relabel(</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a><span class="st">                      DTHFL = "Subject Death Flag"</span></span>
+<span id="cb6-51"><a href="#cb6-51"></a><span class="st">                    )</span></span>
+<span id="cb6-52"><a href="#cb6-52"></a><span class="st">                  '</span>),</span>
+<span id="cb6-53"><a href="#cb6-53"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb6-54"><a href="#cb6-54"></a><span class="st">                  ADAE &lt;- synthetic_cdisc_dataset("latest", "adae") %&gt;%</span></span>
+<span id="cb6-55"><a href="#cb6-55"></a><span class="st">                    df_explicit_na() %&gt;%</span></span>
+<span id="cb6-56"><a href="#cb6-56"></a><span class="st">                    mutate(</span></span>
+<span id="cb6-57"><a href="#cb6-57"></a><span class="st">                      AESDTH = as.character(AESDTH),</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a><span class="st">                      AESDTH = case_when(</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a><span class="st">                        ARM == "A: Drug X" ~ NA_character_,</span></span>
+<span id="cb6-60"><a href="#cb6-60"></a><span class="st">                        TRUE ~ AESDTH),</span></span>
+<span id="cb6-61"><a href="#cb6-61"></a><span class="st">                      AESDTH = as.factor(AESDTH),</span></span>
+<span id="cb6-62"><a href="#cb6-62"></a><span class="st">                      SOC_PT = factor(paste(AEBODSYS, "/", AEDECOD))</span></span>
+<span id="cb6-63"><a href="#cb6-63"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb6-64"><a href="#cb6-64"></a><span class="st">                    filter(AESDTH == "Y") %&gt;%</span></span>
+<span id="cb6-65"><a href="#cb6-65"></a><span class="st">                    mutate(ARM = droplevels(ARM)) %&gt;%</span></span>
+<span id="cb6-66"><a href="#cb6-66"></a><span class="st">                    var_relabel(SOC_PT = "MedDRA SOC and Preferred Term")</span></span>
+<span id="cb6-67"><a href="#cb6-67"></a><span class="st">                  '</span>),</span>
+<span id="cb6-68"><a href="#cb6-68"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-69"><a href="#cb6-69"></a>  ),</span>
+<span id="cb6-70"><a href="#cb6-70"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-71"><a href="#cb6-71"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb6-72"><a href="#cb6-72"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb6-73"><a href="#cb6-73"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb6-74"><a href="#cb6-74"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb6-75"><a href="#cb6-75"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-76"><a href="#cb6-76"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SOC_PT"</span>)),</span>
+<span id="cb6-77"><a href="#cb6-77"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"SOC_PT"</span>)</span>
+<span id="cb6-78"><a href="#cb6-78"></a>      ),</span>
+<span id="cb6-79"><a href="#cb6-79"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-80"><a href="#cb6-80"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SOC_PT"</span>)),</span>
+<span id="cb6-81"><a href="#cb6-81"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb6-82"><a href="#cb6-82"></a>      ),</span>
+<span id="cb6-83"><a href="#cb6-83"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-84"><a href="#cb6-84"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb6-85"><a href="#cb6-85"></a>    )</span>
+<span id="cb6-86"><a href="#cb6-86"></a>  )</span>
+<span id="cb6-87"><a href="#cb6-87"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:16:06.0733 pid:10311 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet07_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet07_cache/html/sessioninfo_5fed9ae5e4755a687c6dfa206d7f74c5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet07_cache/html/snapshot_c51fb7f85cb2a668acd1a2858f21b925">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet07.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+        { trigger: "manual", 
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+        if (codeDiv.classList.contains(fromCls)) {
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../tables/adverse-events/aet06_smq.html" class="pagination-link">
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+      <a href="../../tables/adverse-events/aet09.html" class="pagination-link">
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET07</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events Resulting in Death</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a>For illustrative purposes, we will pre-process <span class="in">`AESDTH`</span> in ADAE so there are no deaths in arm A and concatenate <span class="in">`AEBODSYS`</span> and <span class="in">`AEDECOD`</span> as per GDSR output standards for AET07.</span>
+<span id="cb12-14"><a href="#cb12-14"></a></span>
+<span id="cb12-15"><a href="#cb12-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a></span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-20"><a href="#cb12-20"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-21"><a href="#cb12-21"></a></span>
+<span id="cb12-22"><a href="#cb12-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-23"><a href="#cb12-23"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-24"><a href="#cb12-24"></a></span>
+<span id="cb12-25"><a href="#cb12-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-26"><a href="#cb12-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-27"><a href="#cb12-27"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-28"><a href="#cb12-28"></a></span>
+<span id="cb12-29"><a href="#cb12-29"></a>adae_f <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-31"><a href="#cb12-31"></a>    <span class="at">AESDTH =</span> <span class="fu">as.character</span>(AESDTH), <span class="co"># characterizing AESDTH for next step</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>    <span class="at">AESDTH =</span> <span class="fu">case_when</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>      ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span> <span class="sc">~</span> <span class="cn">NA_character_</span>, <span class="co"># For demonstration purpose only,</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> AESDTH</span>
+<span id="cb12-35"><a href="#cb12-35"></a>    ), <span class="co"># make "A: Drug X" as the arm without AE leading to death</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a>    <span class="at">AESDTH =</span> <span class="fu">as.factor</span>(AESDTH),</span>
+<span id="cb12-37"><a href="#cb12-37"></a>    <span class="at">SOC_PT =</span> <span class="fu">factor</span>(<span class="fu">paste</span>(AEBODSYS, <span class="st">"/"</span>, AEDECOD))</span>
+<span id="cb12-38"><a href="#cb12-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>  <span class="fu">filter</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(ARM))</span>
+<span id="cb12-41"><a href="#cb12-41"></a><span class="in">```</span></span>
+<span id="cb12-42"><a href="#cb12-42"></a></span>
+<span id="cb12-43"><a href="#cb12-43"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a></span>
+<span id="cb12-45"><a href="#cb12-45"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-48"><a href="#cb12-48"></a></span>
+<span id="cb12-49"><a href="#cb12-49"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-50"><a href="#cb12-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels) <span class="sc">%&gt;%</span></span>
+<span id="cb12-51"><a href="#cb12-51"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-52"><a href="#cb12-52"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-53"><a href="#cb12-53"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb12-54"><a href="#cb12-54"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb12-55"><a href="#cb12-55"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-58"><a href="#cb12-58"></a>    <span class="at">vars =</span> <span class="st">"SOC_PT"</span></span>
+<span id="cb12-59"><a href="#cb12-59"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb12-61"><a href="#cb12-61"></a></span>
+<span id="cb12-62"><a href="#cb12-62"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-63"><a href="#cb12-63"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-64"><a href="#cb12-64"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-66"><a href="#cb12-66"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-67"><a href="#cb12-67"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-69"><a href="#cb12-69"></a>    <span class="at">path =</span> <span class="st">"SOC_PT"</span>,</span>
+<span id="cb12-70"><a href="#cb12-70"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb12-71"><a href="#cb12-71"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a>  )</span>
+<span id="cb12-73"><a href="#cb12-73"></a></span>
+<span id="cb12-74"><a href="#cb12-74"></a>result</span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="in">```</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a></span>
+<span id="cb12-77"><a href="#cb12-77"></a><span class="fu">## Table with Fill-In of Treatment Groups without Deaths</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a></span>
+<span id="cb12-79"><a href="#cb12-79"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-80"><a href="#cb12-80"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-81"><a href="#cb12-81"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-83"><a href="#cb12-83"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-84"><a href="#cb12-84"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span>,</span>
+<span id="cb12-85"><a href="#cb12-85"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb12-86"><a href="#cb12-86"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb12-87"><a href="#cb12-87"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-88"><a href="#cb12-88"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-89"><a href="#cb12-89"></a>    <span class="at">vars =</span> <span class="st">"SOC_PT"</span></span>
+<span id="cb12-90"><a href="#cb12-90"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-91"><a href="#cb12-91"></a>  <span class="fu">append_topleft</span>(<span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb12-92"><a href="#cb12-92"></a></span>
+<span id="cb12-93"><a href="#cb12-93"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-95"><a href="#cb12-95"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb12-96"><a href="#cb12-96"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-97"><a href="#cb12-97"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-100"><a href="#cb12-100"></a>    <span class="at">path =</span> <span class="st">"SOC_PT"</span>,</span>
+<span id="cb12-101"><a href="#cb12-101"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb12-102"><a href="#cb12-102"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a>  )</span>
+<span id="cb12-104"><a href="#cb12-104"></a></span>
+<span id="cb12-105"><a href="#cb12-105"></a>result</span>
+<span id="cb12-106"><a href="#cb12-106"></a><span class="in">```</span></span>
+<span id="cb12-107"><a href="#cb12-107"></a></span>
+<span id="cb12-108"><a href="#cb12-108"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-109"><a href="#cb12-109"></a></span>
+<span id="cb12-110"><a href="#cb12-110"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-111"><a href="#cb12-111"></a></span>
+<span id="cb12-112"><a href="#cb12-112"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb12-114"><a href="#cb12-114"></a></span>
+<span id="cb12-115"><a href="#cb12-115"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-119"><a href="#cb12-119"></a></span>
+<span id="cb12-120"><a href="#cb12-120"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-121"><a href="#cb12-121"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-122"><a href="#cb12-122"></a></span>
+<span id="cb12-123"><a href="#cb12-123"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-124"><a href="#cb12-124"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-125"><a href="#cb12-125"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-126"><a href="#cb12-126"></a></span>
+<span id="cb12-127"><a href="#cb12-127"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb12-128"><a href="#cb12-128"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-129"><a href="#cb12-129"></a>    <span class="at">DTHFL =</span> <span class="fu">case_when</span>(</span>
+<span id="cb12-130"><a href="#cb12-130"></a>      <span class="sc">!</span><span class="fu">is.na</span>(DTHDT) <span class="sc">~</span> <span class="st">"Y"</span>,</span>
+<span id="cb12-131"><a href="#cb12-131"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb12-132"><a href="#cb12-132"></a>    )</span>
+<span id="cb12-133"><a href="#cb12-133"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-134"><a href="#cb12-134"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb12-135"><a href="#cb12-135"></a>    <span class="at">DTHFL =</span> <span class="st">"Subject Death Flag"</span></span>
+<span id="cb12-136"><a href="#cb12-136"></a>  )</span>
+<span id="cb12-137"><a href="#cb12-137"></a></span>
+<span id="cb12-138"><a href="#cb12-138"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb12-139"><a href="#cb12-139"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-140"><a href="#cb12-140"></a>    <span class="at">AESDTH =</span> <span class="fu">as.character</span>(AESDTH), <span class="co"># characterizing AESDTH for next step</span></span>
+<span id="cb12-141"><a href="#cb12-141"></a>    <span class="at">AESDTH =</span> <span class="fu">case_when</span>(</span>
+<span id="cb12-142"><a href="#cb12-142"></a>      ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span> <span class="sc">~</span> <span class="cn">NA_character_</span>, <span class="co"># For demonstration purpose only,</span></span>
+<span id="cb12-143"><a href="#cb12-143"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> AESDTH</span>
+<span id="cb12-144"><a href="#cb12-144"></a>    ), <span class="co"># make "A: Drug X" as the arm without AE leading to death</span></span>
+<span id="cb12-145"><a href="#cb12-145"></a>    <span class="at">AESDTH =</span> <span class="fu">as.factor</span>(AESDTH),</span>
+<span id="cb12-146"><a href="#cb12-146"></a>    <span class="at">SOC_PT =</span> <span class="fu">factor</span>(<span class="fu">paste</span>(AEBODSYS, <span class="st">"/"</span>, AEDECOD))</span>
+<span id="cb12-147"><a href="#cb12-147"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-148"><a href="#cb12-148"></a>  <span class="fu">filter</span>(AESDTH <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-149"><a href="#cb12-149"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(ARM)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-150"><a href="#cb12-150"></a>  <span class="fu">var_relabel</span>(<span class="at">SOC_PT =</span> <span class="st">"MedDRA SOC and Preferred Term"</span>)</span>
+<span id="cb12-151"><a href="#cb12-151"></a></span>
+<span id="cb12-152"><a href="#cb12-152"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-154"><a href="#cb12-154"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb12-155"><a href="#cb12-155"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb12-156"><a href="#cb12-156"></a><span class="st">                    df_explicit_na() %&gt;%</span></span>
+<span id="cb12-157"><a href="#cb12-157"></a><span class="st">                    mutate(</span></span>
+<span id="cb12-158"><a href="#cb12-158"></a><span class="st">                      DTHFL = case_when(</span></span>
+<span id="cb12-159"><a href="#cb12-159"></a><span class="st">                        !is.na(DTHDT) ~ "Y",</span></span>
+<span id="cb12-160"><a href="#cb12-160"></a><span class="st">                        TRUE ~ ""</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a><span class="st">                      )</span></span>
+<span id="cb12-162"><a href="#cb12-162"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb12-163"><a href="#cb12-163"></a><span class="st">                    var_relabel(</span></span>
+<span id="cb12-164"><a href="#cb12-164"></a><span class="st">                      DTHFL = "Subject Death Flag"</span></span>
+<span id="cb12-165"><a href="#cb12-165"></a><span class="st">                    )</span></span>
+<span id="cb12-166"><a href="#cb12-166"></a><span class="st">                  '</span>),</span>
+<span id="cb12-167"><a href="#cb12-167"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb12-168"><a href="#cb12-168"></a><span class="st">                  ADAE &lt;- synthetic_cdisc_dataset("latest", "adae") %&gt;%</span></span>
+<span id="cb12-169"><a href="#cb12-169"></a><span class="st">                    df_explicit_na() %&gt;%</span></span>
+<span id="cb12-170"><a href="#cb12-170"></a><span class="st">                    mutate(</span></span>
+<span id="cb12-171"><a href="#cb12-171"></a><span class="st">                      AESDTH = as.character(AESDTH),</span></span>
+<span id="cb12-172"><a href="#cb12-172"></a><span class="st">                      AESDTH = case_when(</span></span>
+<span id="cb12-173"><a href="#cb12-173"></a><span class="st">                        ARM == "A: Drug X" ~ NA_character_,</span></span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="st">                        TRUE ~ AESDTH),</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a><span class="st">                      AESDTH = as.factor(AESDTH),</span></span>
+<span id="cb12-176"><a href="#cb12-176"></a><span class="st">                      SOC_PT = factor(paste(AEBODSYS, "/", AEDECOD))</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb12-178"><a href="#cb12-178"></a><span class="st">                    filter(AESDTH == "Y") %&gt;%</span></span>
+<span id="cb12-179"><a href="#cb12-179"></a><span class="st">                    mutate(ARM = droplevels(ARM)) %&gt;%</span></span>
+<span id="cb12-180"><a href="#cb12-180"></a><span class="st">                    var_relabel(SOC_PT = "MedDRA SOC and Preferred Term")</span></span>
+<span id="cb12-181"><a href="#cb12-181"></a><span class="st">                  '</span>),</span>
+<span id="cb12-182"><a href="#cb12-182"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-183"><a href="#cb12-183"></a>  ),</span>
+<span id="cb12-184"><a href="#cb12-184"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-185"><a href="#cb12-185"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb12-186"><a href="#cb12-186"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb12-187"><a href="#cb12-187"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-188"><a href="#cb12-188"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb12-189"><a href="#cb12-189"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-190"><a href="#cb12-190"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SOC_PT"</span>)),</span>
+<span id="cb12-191"><a href="#cb12-191"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"SOC_PT"</span>)</span>
+<span id="cb12-192"><a href="#cb12-192"></a>      ),</span>
+<span id="cb12-193"><a href="#cb12-193"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-194"><a href="#cb12-194"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>, <span class="st">"SOC_PT"</span>)),</span>
+<span id="cb12-195"><a href="#cb12-195"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb12-196"><a href="#cb12-196"></a>      ),</span>
+<span id="cb12-197"><a href="#cb12-197"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-198"><a href="#cb12-198"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span></span>
+<span id="cb12-199"><a href="#cb12-199"></a>    )</span>
+<span id="cb12-200"><a href="#cb12-200"></a>  )</span>
+<span id="cb12-201"><a href="#cb12-201"></a>)</span>
+<span id="cb12-202"><a href="#cb12-202"></a></span>
+<span id="cb12-203"><a href="#cb12-203"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-204"><a href="#cb12-204"></a><span class="in">```</span></span>
+<span id="cb12-205"><a href="#cb12-205"></a></span>
+<span id="cb12-206"><a href="#cb12-206"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-207"><a href="#cb12-207"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/adverse-events/aet07_files/figure-html/teal-1.png b/stable/tables/adverse-events/aet07_files/figure-html/teal-1.png
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+<meta property="og:title" content="TLG Catalog - AET09">
+<meta property="og:description" content="Adverse Events Related to Study Drug">
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+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet01.html">Adverse Events</a></li><li class="breadcrumb-item"><a href="../../tables/adverse-events/aet09.html">AET09</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
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+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
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+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
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+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
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+          </a> 
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+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET09</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events Related to Study Drug</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Including High-Level Terms</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet09_cache/html/setup_dfa90f36699aee92b09d4e7fedab478d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adae_f <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="fu">var_labels</span>(adae_f) <span class="ot">&lt;-</span> adae_labels</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet09_cache/html/variant1_2c47bc5517f75c4f4ff154f3dc43db22">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events related to study drug"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>    )</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>    )</span>
+<span id="cb2-30"><a href="#cb2-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb2-34"><a href="#cb2-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">append_varlabels</span>(adae_f, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-36"><a href="#cb2-36"></a></span>
+<span id="cb2-37"><a href="#cb2-37"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-41"><a href="#cb2-41"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-43"><a href="#cb2-43"></a></span>
+<span id="cb2-44"><a href="#cb2-44"></a>result <span class="ot">&lt;-</span> tbl1 <span class="sc">%&gt;%</span></span>
+<span id="cb2-45"><a href="#cb2-45"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-47"><a href="#cb2-47"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb2-48"><a href="#cb2-48"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb2-49"><a href="#cb2-49"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-50"><a href="#cb2-50"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-51"><a href="#cb2-51"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-52"><a href="#cb2-52"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-53"><a href="#cb2-53"></a>  )</span>
+<span id="cb2-54"><a href="#cb2-54"></a></span>
+<span id="cb2-55"><a href="#cb2-55"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                          A: Drug X    B: Placebo    C: Combination   All Patients
+  Dictionary-Derived Term                                                            (N=134)       (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event related to study drug     105 (78.4%)   108 (80.6%)    109 (82.6%)     322 (80.5%) 
+Overall total number of events related to study drug                                   282           299            336             917     
+cl D.2                                                                                                                                      
+  Total number of patients with at least one adverse event related to study drug   47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) 
+  Total number of events related to study drug                                         62            72              74             208     
+  dcd D.2.1.5.3                                                                    47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) 
+cl D.1                                                                                                                                      
+  Total number of patients with at least one adverse event related to study drug   50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) 
+  Total number of events related to study drug                                         61            51              71             183     
+  dcd D.1.1.1.1                                                                    50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) 
+cl B.1                                                                                                                                      
+  Total number of patients with at least one adverse event related to study drug   47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) 
+  Total number of events related to study drug                                         56            60              62             178     
+  dcd B.1.1.1.1                                                                    47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) 
+cl C.2                                                                                                                                      
+  Total number of patients with at least one adverse event related to study drug   35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) 
+  Total number of events related to study drug                                         48            53              65             166     
+  dcd C.2.1.2.1                                                                    35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) 
+cl C.1                                                                                                                                      
+  Total number of patients with at least one adverse event related to study drug   43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) 
+  Total number of events related to study drug                                         55            63              64             182     
+  dcd C.1.1.1.3                                                                    43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet09_cache/html/variant2_0df3e2ee6f6023dd4326abedb8ab4502">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events related to study drug"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>    )</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>    )</span>
+<span id="cb4-27"><a href="#cb4-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb4-30"><a href="#cb4-30"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEHLT)</span>
+<span id="cb4-36"><a href="#cb4-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-41"><a href="#cb4-41"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb4-42"><a href="#cb4-42"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>    )</span>
+<span id="cb4-44"><a href="#cb4-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb4-47"><a href="#cb4-47"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)</span>
+<span id="cb4-48"><a href="#cb4-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-49"><a href="#cb4-49"></a>  <span class="fu">append_varlabels</span>(adae_f, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb4-50"><a href="#cb4-50"></a></span>
+<span id="cb4-51"><a href="#cb4-51"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-52"><a href="#cb4-52"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb4-54"><a href="#cb4-54"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-55"><a href="#cb4-55"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-56"><a href="#cb4-56"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb4-57"><a href="#cb4-57"></a></span>
+<span id="cb4-58"><a href="#cb4-58"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span></span>
+<span id="cb4-59"><a href="#cb4-59"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-60"><a href="#cb4-60"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb4-61"><a href="#cb4-61"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb4-62"><a href="#cb4-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-63"><a href="#cb4-63"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-64"><a href="#cb4-64"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb4-65"><a href="#cb4-65"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb4-66"><a href="#cb4-66"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-67"><a href="#cb4-67"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-68"><a href="#cb4-68"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb4-69"><a href="#cb4-69"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-70"><a href="#cb4-70"></a>  )</span>
+<span id="cb4-71"><a href="#cb4-71"></a></span>
+<span id="cb4-72"><a href="#cb4-72"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                                                                       
+  High Level Term                                                                       A: Drug X    B: Placebo    C: Combination
+    Dictionary-Derived Term                                                              (N=134)       (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event related to study drug         105 (78.4%)   108 (80.6%)    109 (82.6%)  
+Overall total number of events related to study drug                                       282           299            336      
+  cl D.2                                                                                                                         
+    Total number of patients with at least one adverse event related to study drug     47 (35.1%)    58 (43.3%)      57 (43.2%)  
+    Total number of events related to study drug                                           62            72              74      
+    hlt D.2.1.5                                                                                                                  
+      Total number of patients with at least one adverse event related to study drug   47 (35.1%)    58 (43.3%)      57 (43.2%)  
+      Total number of events related to study drug                                         62            72              74      
+      dcd D.2.1.5.3                                                                    47 (35.1%)    58 (43.3%)      57 (43.2%)  
+  cl D.1                                                                                                                         
+    Total number of patients with at least one adverse event related to study drug     50 (37.3%)    42 (31.3%)      51 (38.6%)  
+    Total number of events related to study drug                                           61            51              71      
+    hlt D.1.1.1                                                                                                                  
+      Total number of patients with at least one adverse event related to study drug   50 (37.3%)    42 (31.3%)      51 (38.6%)  
+      Total number of events related to study drug                                         61            51              71      
+      dcd D.1.1.1.1                                                                    50 (37.3%)    42 (31.3%)      51 (38.6%)  
+  cl B.1                                                                                                                         
+    Total number of patients with at least one adverse event related to study drug     47 (35.1%)    49 (36.6%)      43 (32.6%)  
+    Total number of events related to study drug                                           56            60              62      
+    hlt B.1.1.1                                                                                                                  
+      Total number of patients with at least one adverse event related to study drug   47 (35.1%)    49 (36.6%)      43 (32.6%)  
+      Total number of events related to study drug                                         56            60              62      
+      dcd B.1.1.1.1                                                                    47 (35.1%)    49 (36.6%)      43 (32.6%)  
+  cl C.2                                                                                                                         
+    Total number of patients with at least one adverse event related to study drug     35 (26.1%)    48 (35.8%)      55 (41.7%)  
+    Total number of events related to study drug                                           48            53              65      
+    hlt C.2.1.2                                                                                                                  
+      Total number of patients with at least one adverse event related to study drug   35 (26.1%)    48 (35.8%)      55 (41.7%)  
+      Total number of events related to study drug                                         48            53              65      
+      dcd C.2.1.2.1                                                                    35 (26.1%)    48 (35.8%)      55 (41.7%)  
+  cl C.1                                                                                                                         
+    Total number of patients with at least one adverse event related to study drug     43 (32.1%)    46 (34.3%)      43 (32.6%)  
+    Total number of events related to study drug                                           55            63              64      
+    hlt C.1.1.1                                                                                                                  
+      Total number of patients with at least one adverse event related to study drug   43 (32.1%)    46 (34.3%)      43 (32.6%)  
+      Total number of events related to study drug                                         55            63              64      
+      dcd C.1.1.1.3                                                                    43 (32.1%)    46 (34.3%)      43 (32.6%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="aet09_cache/html/teal_04b023682db2ff73165ce9046ed505f5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal)</span>
+<span id="cb6-4"><a href="#cb6-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-8"><a href="#cb6-8"></a></span>
+<span id="cb6-9"><a href="#cb6-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-11"><a href="#cb6-11"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb6-12"><a href="#cb6-12"></a></span>
+<span id="cb6-13"><a href="#cb6-13"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      adsl,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>    ),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb6-21"><a href="#cb6-21"></a>      <span class="st">"ADAE"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      adae,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>    ),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>  ),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb6-29"><a href="#cb6-29"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Related to Study Drug"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-33"><a href="#cb6-33"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb6-34"><a href="#cb6-34"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      ),</span>
+<span id="cb6-36"><a href="#cb6-36"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-37"><a href="#cb6-37"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AEHLT"</span>)),</span>
+<span id="cb6-38"><a href="#cb6-38"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>)</span>
+<span id="cb6-39"><a href="#cb6-39"></a>      ),</span>
+<span id="cb6-40"><a href="#cb6-40"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>      <span class="at">event_type =</span> <span class="st">"adverse event related to study drug"</span>, <span class="co"># define event type here</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>    )</span>
+<span id="cb6-43"><a href="#cb6-43"></a>  ),</span>
+<span id="cb6-44"><a href="#cb6-44"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADAE =</span> <span class="fu">list</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>)) <span class="co"># related AEs only</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:16:34.0655 pid:10409 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet09_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet09_cache/html/sessioninfo_16b3f5eb54e72722312565a02e72d132">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet09_cache/html/snapshot_b98b1149f19d6bcb7cb0e5c0e1dcf077">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet09.lock">Download</a></p>
+</section>
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+    if (parentEl) {
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+        };
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
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+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet07.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AET07</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/adverse-events/aet09_smq.html" class="pagination-link">
+        <span class="nav-page-text">AET09_SMQ</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET09</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events Related to Study Drug</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a>adae_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adae)</span>
+<span id="cb12-28"><a href="#cb12-28"></a></span>
+<span id="cb12-29"><a href="#cb12-29"></a>adae_f <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">filter</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-31"><a href="#cb12-31"></a></span>
+<span id="cb12-32"><a href="#cb12-32"></a><span class="fu">var_labels</span>(adae_f) <span class="ot">&lt;-</span> adae_labels</span>
+<span id="cb12-33"><a href="#cb12-33"></a><span class="in">```</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a></span>
+<span id="cb12-35"><a href="#cb12-35"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a></span>
+<span id="cb12-37"><a href="#cb12-37"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-40"><a href="#cb12-40"></a></span>
+<span id="cb12-41"><a href="#cb12-41"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-42"><a href="#cb12-42"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-43"><a href="#cb12-43"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-45"><a href="#cb12-45"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-46"><a href="#cb12-46"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-48"><a href="#cb12-48"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb12-49"><a href="#cb12-49"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events related to study drug"</span></span>
+<span id="cb12-50"><a href="#cb12-50"></a>    )</span>
+<span id="cb12-51"><a href="#cb12-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-52"><a href="#cb12-52"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-53"><a href="#cb12-53"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb12-54"><a href="#cb12-54"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-55"><a href="#cb12-55"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-56"><a href="#cb12-56"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-57"><a href="#cb12-57"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-58"><a href="#cb12-58"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb12-59"><a href="#cb12-59"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-61"><a href="#cb12-61"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-62"><a href="#cb12-62"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-63"><a href="#cb12-63"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-64"><a href="#cb12-64"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb12-65"><a href="#cb12-65"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a>    )</span>
+<span id="cb12-67"><a href="#cb12-67"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-69"><a href="#cb12-69"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-70"><a href="#cb12-70"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L</span>
+<span id="cb12-71"><a href="#cb12-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a>  <span class="fu">append_varlabels</span>(adae_f, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-73"><a href="#cb12-73"></a></span>
+<span id="cb12-74"><a href="#cb12-74"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-75"><a href="#cb12-75"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-76"><a href="#cb12-76"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb12-77"><a href="#cb12-77"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-78"><a href="#cb12-78"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-79"><a href="#cb12-79"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb12-80"><a href="#cb12-80"></a></span>
+<span id="cb12-81"><a href="#cb12-81"></a>result <span class="ot">&lt;-</span> tbl1 <span class="sc">%&gt;%</span></span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-84"><a href="#cb12-84"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb12-85"><a href="#cb12-85"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb12-86"><a href="#cb12-86"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-87"><a href="#cb12-87"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-88"><a href="#cb12-88"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb12-89"><a href="#cb12-89"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb12-90"><a href="#cb12-90"></a>  )</span>
+<span id="cb12-91"><a href="#cb12-91"></a></span>
+<span id="cb12-92"><a href="#cb12-92"></a>result</span>
+<span id="cb12-93"><a href="#cb12-93"></a><span class="in">```</span></span>
+<span id="cb12-94"><a href="#cb12-94"></a></span>
+<span id="cb12-95"><a href="#cb12-95"></a><span class="fu">## Table Including High-Level Terms</span></span>
+<span id="cb12-96"><a href="#cb12-96"></a></span>
+<span id="cb12-97"><a href="#cb12-97"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-101"><a href="#cb12-101"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-102"><a href="#cb12-102"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-103"><a href="#cb12-103"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-104"><a href="#cb12-104"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb12-105"><a href="#cb12-105"></a>      <span class="at">nonunique =</span> <span class="st">"Overall total number of events related to study drug"</span></span>
+<span id="cb12-106"><a href="#cb12-106"></a>    )</span>
+<span id="cb12-107"><a href="#cb12-107"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-108"><a href="#cb12-108"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-109"><a href="#cb12-109"></a>    <span class="st">"AEBODSYS"</span>,</span>
+<span id="cb12-110"><a href="#cb12-110"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-111"><a href="#cb12-111"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-112"><a href="#cb12-112"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-113"><a href="#cb12-113"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb12-114"><a href="#cb12-114"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-115"><a href="#cb12-115"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb12-116"><a href="#cb12-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-118"><a href="#cb12-118"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-119"><a href="#cb12-119"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-120"><a href="#cb12-120"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-121"><a href="#cb12-121"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb12-122"><a href="#cb12-122"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb12-123"><a href="#cb12-123"></a>    )</span>
+<span id="cb12-124"><a href="#cb12-124"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-125"><a href="#cb12-125"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-126"><a href="#cb12-126"></a>    <span class="st">"AEHLT"</span>,</span>
+<span id="cb12-127"><a href="#cb12-127"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-128"><a href="#cb12-128"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-129"><a href="#cb12-129"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb12-130"><a href="#cb12-130"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-131"><a href="#cb12-131"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-132"><a href="#cb12-132"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_f<span class="sc">$</span>AEHLT)</span>
+<span id="cb12-133"><a href="#cb12-133"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-134"><a href="#cb12-134"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-135"><a href="#cb12-135"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-136"><a href="#cb12-136"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-137"><a href="#cb12-137"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-138"><a href="#cb12-138"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event related to study drug"</span>,</span>
+<span id="cb12-139"><a href="#cb12-139"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events related to study drug"</span></span>
+<span id="cb12-140"><a href="#cb12-140"></a>    )</span>
+<span id="cb12-141"><a href="#cb12-141"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-142"><a href="#cb12-142"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-143"><a href="#cb12-143"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-144"><a href="#cb12-144"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="sc">-</span>1L)</span>
+<span id="cb12-145"><a href="#cb12-145"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-146"><a href="#cb12-146"></a>  <span class="fu">append_varlabels</span>(adae_f, <span class="fu">c</span>(<span class="st">"AEDECOD"</span>), <span class="at">indent =</span> 2L)</span>
+<span id="cb12-147"><a href="#cb12-147"></a></span>
+<span id="cb12-148"><a href="#cb12-148"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-149"><a href="#cb12-149"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-150"><a href="#cb12-150"></a>  <span class="at">df =</span> adae_f,</span>
+<span id="cb12-151"><a href="#cb12-151"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-152"><a href="#cb12-152"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb12-154"><a href="#cb12-154"></a></span>
+<span id="cb12-155"><a href="#cb12-155"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span></span>
+<span id="cb12-156"><a href="#cb12-156"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-157"><a href="#cb12-157"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>),</span>
+<span id="cb12-158"><a href="#cb12-158"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb12-159"><a href="#cb12-159"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-160"><a href="#cb12-160"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-161"><a href="#cb12-161"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>),</span>
+<span id="cb12-162"><a href="#cb12-162"></a>    <span class="at">scorefun =</span> cont_n_allcols</span>
+<span id="cb12-163"><a href="#cb12-163"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-164"><a href="#cb12-164"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-165"><a href="#cb12-165"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"AEHLT"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>),</span>
+<span id="cb12-166"><a href="#cb12-166"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb12-167"><a href="#cb12-167"></a>  )</span>
+<span id="cb12-168"><a href="#cb12-168"></a></span>
+<span id="cb12-169"><a href="#cb12-169"></a>result</span>
+<span id="cb12-170"><a href="#cb12-170"></a><span class="in">```</span></span>
+<span id="cb12-171"><a href="#cb12-171"></a></span>
+<span id="cb12-172"><a href="#cb12-172"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-173"><a href="#cb12-173"></a></span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a></span>
+<span id="cb12-176"><a href="#cb12-176"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb12-178"><a href="#cb12-178"></a></span>
+<span id="cb12-179"><a href="#cb12-179"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-180"><a href="#cb12-180"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-181"><a href="#cb12-181"></a><span class="fu">library</span>(teal)</span>
+<span id="cb12-182"><a href="#cb12-182"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-183"><a href="#cb12-183"></a></span>
+<span id="cb12-184"><a href="#cb12-184"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-185"><a href="#cb12-185"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-186"><a href="#cb12-186"></a></span>
+<span id="cb12-187"><a href="#cb12-187"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-188"><a href="#cb12-188"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-189"><a href="#cb12-189"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-190"><a href="#cb12-190"></a></span>
+<span id="cb12-191"><a href="#cb12-191"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb12-192"><a href="#cb12-192"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-193"><a href="#cb12-193"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb12-194"><a href="#cb12-194"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb12-195"><a href="#cb12-195"></a>      adsl,</span>
+<span id="cb12-196"><a href="#cb12-196"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb12-197"><a href="#cb12-197"></a>    ),</span>
+<span id="cb12-198"><a href="#cb12-198"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb12-199"><a href="#cb12-199"></a>      <span class="st">"ADAE"</span>,</span>
+<span id="cb12-200"><a href="#cb12-200"></a>      adae,</span>
+<span id="cb12-201"><a href="#cb12-201"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span></span>
+<span id="cb12-202"><a href="#cb12-202"></a>    ),</span>
+<span id="cb12-203"><a href="#cb12-203"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-204"><a href="#cb12-204"></a>  ),</span>
+<span id="cb12-205"><a href="#cb12-205"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-206"><a href="#cb12-206"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb12-207"><a href="#cb12-207"></a>      <span class="at">label =</span> <span class="st">"Adverse Events Related to Study Drug"</span>,</span>
+<span id="cb12-208"><a href="#cb12-208"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-209"><a href="#cb12-209"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb12-210"><a href="#cb12-210"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-211"><a href="#cb12-211"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb12-212"><a href="#cb12-212"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-213"><a href="#cb12-213"></a>      ),</span>
+<span id="cb12-214"><a href="#cb12-214"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-215"><a href="#cb12-215"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AEHLT"</span>)),</span>
+<span id="cb12-216"><a href="#cb12-216"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>)</span>
+<span id="cb12-217"><a href="#cb12-217"></a>      ),</span>
+<span id="cb12-218"><a href="#cb12-218"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-219"><a href="#cb12-219"></a>      <span class="at">event_type =</span> <span class="st">"adverse event related to study drug"</span>, <span class="co"># define event type here</span></span>
+<span id="cb12-220"><a href="#cb12-220"></a>    )</span>
+<span id="cb12-221"><a href="#cb12-221"></a>  ),</span>
+<span id="cb12-222"><a href="#cb12-222"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADAE =</span> <span class="fu">list</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>)) <span class="co"># related AEs only</span></span>
+<span id="cb12-223"><a href="#cb12-223"></a>)</span>
+<span id="cb12-224"><a href="#cb12-224"></a></span>
+<span id="cb12-225"><a href="#cb12-225"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-226"><a href="#cb12-226"></a><span class="in">```</span></span>
+<span id="cb12-227"><a href="#cb12-227"></a></span>
+<span id="cb12-228"><a href="#cb12-228"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-229"><a href="#cb12-229"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/tables/adverse-events/aet09_files/figure-html/teal-1.png b/stable/tables/adverse-events/aet09_files/figure-html/teal-1.png
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+++ b/stable/tables/adverse-events/aet09_smq.html
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET09_SMQ</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Adverse Events Related to Study Drug by Standardized MedDRA Query</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Customized Queries</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet09_smq_cache/html/setup_0b75b24033aba00624cfcbe9a338c6de">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># levels. For details, refer to Teal and Study Data article.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="co"># AEs are filtered for relatedness to study drug.</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adae_rel <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>)</span>
+<span id="cb1-28"><a href="#cb1-28"></a></span>
+<span id="cb1-29"><a href="#cb1-29"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb1-37"><a href="#cb1-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb1-40"><a href="#cb1-40"></a></span>
+<span id="cb1-41"><a href="#cb1-41"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(<span class="at">df =</span> adae_rel, <span class="at">aag_summary =</span> aag_summary, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>))</span>
+<span id="cb1-43"><a href="#cb1-43"></a></span>
+<span id="cb1-44"><a href="#cb1-44"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-52"><a href="#cb1-52"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb1-53"><a href="#cb1-53"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet09_smq_cache/html/variant1_58dcf4e3d22b786cc19533670d403783">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>    )</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>    )</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-34"><a href="#cb2-34"></a></span>
+<span id="cb2-35"><a href="#cb2-35"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  lyt,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-39"><a href="#cb2-39"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-43"><a href="#cb2-43"></a></span>
+<span id="cb2-44"><a href="#cb2-44"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                      ARM A        ARM B        ARM C   
+  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     43 (32.1%)   46 (34.3%)   43 (32.6%)
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  
+  Total number of patients with at least one adverse event   43 (32.1%)   46 (34.3%)   43 (32.6%)
+  Total number of events                                         55           63           64    
+  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet09_smq_cache/html/variant2_77c68e956052797e1b795b1c6cfab67b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb4-3"><a href="#cb4-3"></a>}</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>    )</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>    ),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-36"><a href="#cb4-36"></a></span>
+<span id="cb4-37"><a href="#cb4-37"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb4-40"><a href="#cb4-40"></a>}</span>
+<span id="cb4-41"><a href="#cb4-41"></a></span>
+<span id="cb4-42"><a href="#cb4-42"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-43"><a href="#cb4-43"></a>  lyt,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-46"><a href="#cb4-46"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-49"><a href="#cb4-49"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-50"><a href="#cb4-50"></a></span>
+<span id="cb4-51"><a href="#cb4-51"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Standardized MedDRA Query                                      ARM A        ARM B        ARM C   
+  Dictionary-Derived Term                                     (N=134)      (N=134)      (N=132)  
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one adverse event     69 (51.5%)   78 (58.2%)   77 (58.3%)
+D.2.1.5.3/A.1.1.1.1 AESI                                                                         
+  Total number of patients with at least one adverse event   47 (35.1%)   58 (43.3%)   57 (43.2%)
+  Total number of events                                         62           72           74    
+  dcd D.2.1.5.3                                              47 (35.1%)   58 (43.3%)   57 (43.2%)
+C.1.1.1.3/B.2.2.3.1 AESI(BROAD)                                                                  
+  Total number of patients with at least one adverse event   43 (32.1%)   46 (34.3%)   43 (32.6%)
+  Total number of events                                         55           63           64    
+  dcd C.1.1.1.3                                              43 (32.1%)   46 (34.3%)   43 (32.6%)
+non observed SMQ02NAM level(BROAD)                                                               
+  Total number of patients with at least one adverse event       0            0            0     
+  Total number of events                                         0            0            0     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>Note that filtering AEs for relatedness to study drug is not a necessary data pre-processing step for the module. It can be achieved using the <code>teal</code> module filter panel. The example here pre-sets the filters using <code>AEREL = "Y"</code> in <code>adae</code>.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="aet09_smq_cache/html/teal_4d8e3e057b534f1f5e96e466852dd2e4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-9"><a href="#cb6-9"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a></span>
+<span id="cb6-11"><a href="#cb6-11"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb6-14"><a href="#cb6-14"></a>)</span>
+<span id="cb6-15"><a href="#cb6-15"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>)</span>
+<span id="cb6-20"><a href="#cb6-20"></a></span>
+<span id="cb6-21"><a href="#cb6-21"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>    ),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>    ),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  ),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by SMQ Table"</span>,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>      ),</span>
+<span id="cb6-39"><a href="#cb6-39"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-40"><a href="#cb6-40"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb6-42"><a href="#cb6-42"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-43"><a href="#cb6-43"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb6-44"><a href="#cb6-44"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>      )</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    )</span>
+<span id="cb6-47"><a href="#cb6-47"></a>  ),</span>
+<span id="cb6-48"><a href="#cb6-48"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADAE =</span> <span class="fu">list</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>))</span>
+<span id="cb6-49"><a href="#cb6-49"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:17:09.7388 pid:10507 token:[] teal.modules.clinical Initializing tm_t_smq</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet09_smq_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet09_smq_cache/html/sessioninfo_9bd530d31fb98c08aceb6a3c558dcaa3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] stringr_1.5.0                scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] stringi_1.7.12        gtable_0.3.4          later_1.3.1          
+[61] shinycssloaders_1.0.0 munsell_0.5.0         tibble_3.2.1         
+[64] logger_0.2.2          pillar_1.9.0          htmltools_0.5.6      
+[67] brio_1.1.3            R6_2.5.1              Rdpack_2.5           
+[70] evaluate_0.21         lattice_0.21-8        rbibutils_2.2.15     
+[73] backports_1.4.1       memoise_2.0.1         broom_1.0.5          
+[76] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[79] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[82] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[85] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet09_smq_cache/html/snapshot_ad611006ace696a0f0ba8c4de300fdb9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet09_smq.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET09_SMQ</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Adverse Events Related to Study Drug by Standardized MedDRA Query</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb12-20"><a href="#cb12-20"></a></span>
+<span id="cb12-21"><a href="#cb12-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-23"><a href="#cb12-23"></a></span>
+<span id="cb12-24"><a href="#cb12-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing</span></span>
+<span id="cb12-25"><a href="#cb12-25"></a><span class="co"># levels. For details, refer to Teal and Study Data article.</span></span>
+<span id="cb12-26"><a href="#cb12-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-27"><a href="#cb12-27"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-28"><a href="#cb12-28"></a></span>
+<span id="cb12-29"><a href="#cb12-29"></a><span class="co"># AEs are filtered for relatedness to study drug.</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>adae_rel <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AEREL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-31"><a href="#cb12-31"></a></span>
+<span id="cb12-32"><a href="#cb12-32"></a><span class="co"># Simulate a random AAG dataset.</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>aag <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb12-34"><a href="#cb12-34"></a>  <span class="at">NAMVAR =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"CQ01NAM"</span>),</span>
+<span id="cb12-35"><a href="#cb12-35"></a>  <span class="at">SRCVAR =</span> <span class="fu">rep</span>(<span class="st">"AEDECOD"</span>, <span class="dv">5</span>),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>  <span class="at">GRPTYPE =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"SMQ"</span>, <span class="st">"CUSTOM"</span>, <span class="st">"CUSTOM"</span>),</span>
+<span id="cb12-37"><a href="#cb12-37"></a>  <span class="at">REFID =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">3</span>),</span>
+<span id="cb12-38"><a href="#cb12-38"></a>  <span class="at">REFNAME =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"C.1.1.1.3/B.2.2.3.1 AESI"</span>, <span class="dv">2</span>), <span class="st">"non observed SMQ02NAM level"</span>, <span class="fu">rep</span>(<span class="st">"D.2.1.5.3/A.1.1.1.1 AESI"</span>, <span class="dv">2</span>)),</span>
+<span id="cb12-39"><a href="#cb12-39"></a>  <span class="at">SCOPE =</span> <span class="fu">c</span>(<span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">"BROAD"</span>, <span class="st">""</span>, <span class="st">""</span>),</span>
+<span id="cb12-40"><a href="#cb12-40"></a>  <span class="at">REFTERM =</span> <span class="fu">c</span>(<span class="st">"C.1.1.1.3"</span>, <span class="st">"B.2.2.3.1"</span>, <span class="st">"Z.9.9.9.9"</span>, <span class="st">"D.2.1.5.3"</span>, <span class="st">"A.1.1.1.1"</span>),</span>
+<span id="cb12-41"><a href="#cb12-41"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-42"><a href="#cb12-42"></a>)</span>
+<span id="cb12-43"><a href="#cb12-43"></a></span>
+<span id="cb12-44"><a href="#cb12-44"></a><span class="co"># Create summary AAG dataset (used for labelling).</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a><span class="co"># Note it's important to incorporate SCOPE into the basket names for SMQs so as to</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a><span class="co"># match the flags present in ADAE.</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>aag_summary <span class="ot">&lt;-</span> aag <span class="sc">%&gt;%</span></span>
+<span id="cb12-48"><a href="#cb12-48"></a>  <span class="fu">select</span>(NAMVAR, REFNAME, SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="fu">unique</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-50"><a href="#cb12-50"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-51"><a href="#cb12-51"></a>    <span class="at">REFNAME_SCOPE =</span> <span class="fu">ifelse</span>(SCOPE <span class="sc">==</span> <span class="st">""</span>, REFNAME, <span class="fu">paste0</span>(REFNAME, <span class="st">"("</span>, SCOPE, <span class="st">")"</span>))</span>
+<span id="cb12-52"><a href="#cb12-52"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a>  <span class="fu">rename</span>(<span class="at">basket =</span> NAMVAR, <span class="at">basket_name =</span> REFNAME_SCOPE) <span class="sc">%&gt;%</span></span>
+<span id="cb12-54"><a href="#cb12-54"></a>  <span class="fu">select</span>(basket, basket_name)</span>
+<span id="cb12-55"><a href="#cb12-55"></a></span>
+<span id="cb12-56"><a href="#cb12-56"></a><span class="co"># Make a summary of the full ADAE based on AAG by using h_stack_by_baskets helper function</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>adae_smq_all <span class="ot">&lt;-</span> <span class="fu">h_stack_by_baskets</span>(<span class="at">df =</span> adae_rel, <span class="at">aag_summary =</span> aag_summary, <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"AEDECOD"</span>))</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a><span class="co"># Post-process adae_smq_all to keep only certain baskets of interest for variant 1</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a><span class="co"># Not need to drop baskets for variant 2 as all baskets will be considered.</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>baskets_to_drop_variant <span class="ot">&lt;-</span> aag_summary<span class="sc">$</span>basket_name[<span class="sc">!</span>aag_summary<span class="sc">$</span>basket <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>)]</span>
+<span id="cb12-62"><a href="#cb12-62"></a></span>
+<span id="cb12-63"><a href="#cb12-63"></a><span class="co"># Adjust the analysis dataset based on basket subset for variant 1.</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a>adae_smq_1 <span class="ot">&lt;-</span> adae_smq_all <span class="sc">%&gt;%</span></span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="fu">filter</span>(<span class="sc">!</span>adae_smq_all<span class="sc">$</span>SMQ <span class="sc">%in%</span> baskets_to_drop_variant) <span class="sc">%&gt;%</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-67"><a href="#cb12-67"></a>    <span class="at">SMQ =</span> tern<span class="sc">::</span><span class="fu">fct_discard</span>(SMQ, <span class="at">discard =</span> baskets_to_drop_variant)</span>
+<span id="cb12-68"><a href="#cb12-68"></a>  )</span>
+<span id="cb12-69"><a href="#cb12-69"></a><span class="in">```</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a></span>
+<span id="cb12-71"><a href="#cb12-71"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a></span>
+<span id="cb12-73"><a href="#cb12-73"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-74"><a href="#cb12-74"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr)</span>
+<span id="cb12-75"><a href="#cb12-75"></a></span>
+<span id="cb12-76"><a href="#cb12-76"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-77"><a href="#cb12-77"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-79"><a href="#cb12-79"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-80"><a href="#cb12-80"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb12-81"><a href="#cb12-81"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-82"><a href="#cb12-82"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>    )</span>
+<span id="cb12-84"><a href="#cb12-84"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-85"><a href="#cb12-85"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-86"><a href="#cb12-86"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb12-87"><a href="#cb12-87"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-88"><a href="#cb12-88"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-89"><a href="#cb12-89"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-90"><a href="#cb12-90"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-91"><a href="#cb12-91"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb12-92"><a href="#cb12-92"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb12-94"><a href="#cb12-94"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-95"><a href="#cb12-95"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-97"><a href="#cb12-97"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb12-98"><a href="#cb12-98"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a>    )</span>
+<span id="cb12-100"><a href="#cb12-100"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-101"><a href="#cb12-101"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-102"><a href="#cb12-102"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-103"><a href="#cb12-103"></a>    <span class="at">.indent_mods =</span> <span class="sc">-</span>1L,</span>
+<span id="cb12-104"><a href="#cb12-104"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-105"><a href="#cb12-105"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-106"><a href="#cb12-106"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-107"><a href="#cb12-107"></a></span>
+<span id="cb12-108"><a href="#cb12-108"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-109"><a href="#cb12-109"></a>  lyt,</span>
+<span id="cb12-110"><a href="#cb12-110"></a>  <span class="at">df =</span> adae_smq_1,</span>
+<span id="cb12-111"><a href="#cb12-111"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-112"><a href="#cb12-112"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb12-114"><a href="#cb12-114"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-115"><a href="#cb12-115"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb12-116"><a href="#cb12-116"></a></span>
+<span id="cb12-117"><a href="#cb12-117"></a>result</span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="in">```</span></span>
+<span id="cb12-119"><a href="#cb12-119"></a></span>
+<span id="cb12-120"><a href="#cb12-120"></a><span class="fu">## Table with Customized Queries</span></span>
+<span id="cb12-121"><a href="#cb12-121"></a></span>
+<span id="cb12-122"><a href="#cb12-122"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-123"><a href="#cb12-123"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb12-124"><a href="#cb12-124"></a>  <span class="sc">!</span><span class="fu">is</span>(tr, <span class="st">"ContentRow"</span>) <span class="sc">&amp;&amp;</span> <span class="fu">all_zero_or_na</span>(tr) <span class="sc">&amp;&amp;</span> <span class="sc">!</span><span class="fu">grepl</span>(<span class="st">"Total number of"</span>, <span class="fu">obj_label</span>(tr))</span>
+<span id="cb12-125"><a href="#cb12-125"></a>}</span>
+<span id="cb12-126"><a href="#cb12-126"></a></span>
+<span id="cb12-127"><a href="#cb12-127"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-128"><a href="#cb12-128"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-129"><a href="#cb12-129"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-130"><a href="#cb12-130"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-131"><a href="#cb12-131"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb12-132"><a href="#cb12-132"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-133"><a href="#cb12-133"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span></span>
+<span id="cb12-134"><a href="#cb12-134"></a>    )</span>
+<span id="cb12-135"><a href="#cb12-135"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-136"><a href="#cb12-136"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-137"><a href="#cb12-137"></a>    <span class="st">"SMQ"</span>,</span>
+<span id="cb12-138"><a href="#cb12-138"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-139"><a href="#cb12-139"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-140"><a href="#cb12-140"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"AEDECOD"</span>, <span class="at">drop_outlevs =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-141"><a href="#cb12-141"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-142"><a href="#cb12-142"></a>    <span class="at">split_label =</span> <span class="st">"Standardized MedDRA Query"</span></span>
+<span id="cb12-143"><a href="#cb12-143"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-144"><a href="#cb12-144"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb12-145"><a href="#cb12-145"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-146"><a href="#cb12-146"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb12-147"><a href="#cb12-147"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb12-148"><a href="#cb12-148"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one adverse event"</span>,</span>
+<span id="cb12-149"><a href="#cb12-149"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of events"</span></span>
+<span id="cb12-150"><a href="#cb12-150"></a>    ),</span>
+<span id="cb12-151"><a href="#cb12-151"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb12-152"><a href="#cb12-152"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb12-154"><a href="#cb12-154"></a>    <span class="at">vars =</span> <span class="st">"AEDECOD"</span>,</span>
+<span id="cb12-155"><a href="#cb12-155"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-156"><a href="#cb12-156"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-157"><a href="#cb12-157"></a>  <span class="fu">append_varlabels</span>(adae, <span class="st">"AEDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-158"><a href="#cb12-158"></a></span>
+<span id="cb12-159"><a href="#cb12-159"></a>score_ae_pts <span class="ot">&lt;-</span> <span class="cf">function</span>(tt) {</span>
+<span id="cb12-160"><a href="#cb12-160"></a>  count_vals <span class="ot">&lt;-</span> <span class="fu">cell_values</span>(<span class="fu">tree_children</span>(tt)[[<span class="st">"USUBJID"</span>]])[[<span class="dv">1</span>]]</span>
+<span id="cb12-161"><a href="#cb12-161"></a>  <span class="fu">sum</span>(<span class="fu">matrix</span>(<span class="fu">unlist</span>(count_vals), <span class="at">nrow =</span> <span class="fu">length</span>(count_vals), <span class="at">byrow =</span> <span class="cn">TRUE</span>)[, <span class="dv">1</span>])</span>
+<span id="cb12-162"><a href="#cb12-162"></a>}</span>
+<span id="cb12-163"><a href="#cb12-163"></a></span>
+<span id="cb12-164"><a href="#cb12-164"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-165"><a href="#cb12-165"></a>  lyt,</span>
+<span id="cb12-166"><a href="#cb12-166"></a>  <span class="at">df =</span> adae_smq_all,</span>
+<span id="cb12-167"><a href="#cb12-167"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-168"><a href="#cb12-168"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-169"><a href="#cb12-169"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>), <span class="at">scorefun =</span> score_ae_pts) <span class="sc">%&gt;%</span></span>
+<span id="cb12-170"><a href="#cb12-170"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"SMQ"</span>, <span class="st">"*"</span>, <span class="st">"AEDECOD"</span>), <span class="at">scorefun =</span> score_occurrences, <span class="at">na.pos =</span> <span class="st">"last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-171"><a href="#cb12-171"></a>  <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb12-172"><a href="#cb12-172"></a></span>
+<span id="cb12-173"><a href="#cb12-173"></a>result</span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="in">```</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a></span>
+<span id="cb12-176"><a href="#cb12-176"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-177"><a href="#cb12-177"></a></span>
+<span id="cb12-178"><a href="#cb12-178"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-179"><a href="#cb12-179"></a></span>
+<span id="cb12-180"><a href="#cb12-180"></a>Note that filtering AEs for relatedness to study drug is not a necessary data pre-processing step for the module.</span>
+<span id="cb12-181"><a href="#cb12-181"></a>It can be achieved using the <span class="in">`teal`</span> module filter panel.</span>
+<span id="cb12-182"><a href="#cb12-182"></a>The example here pre-sets the filters using <span class="in">`AEREL = "Y"`</span> in <span class="in">`adae`</span>.</span>
+<span id="cb12-183"><a href="#cb12-183"></a></span>
+<span id="cb12-184"><a href="#cb12-184"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-185"><a href="#cb12-185"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb12-186"><a href="#cb12-186"></a></span>
+<span id="cb12-187"><a href="#cb12-187"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-188"><a href="#cb12-188"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-189"><a href="#cb12-189"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-190"><a href="#cb12-190"></a></span>
+<span id="cb12-191"><a href="#cb12-191"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-192"><a href="#cb12-192"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-193"><a href="#cb12-193"></a></span>
+<span id="cb12-194"><a href="#cb12-194"></a>names_baskets <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^(SMQ|CQ).*NAM$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-195"><a href="#cb12-195"></a>names_scopes <span class="ot">&lt;-</span> <span class="fu">grep</span>(<span class="st">"^SMQ.*SC$"</span>, <span class="fu">names</span>(adae), <span class="at">value =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-196"><a href="#cb12-196"></a></span>
+<span id="cb12-197"><a href="#cb12-197"></a>cs_baskets <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-198"><a href="#cb12-198"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_baskets),</span>
+<span id="cb12-199"><a href="#cb12-199"></a>  <span class="at">selected =</span> names_baskets</span>
+<span id="cb12-200"><a href="#cb12-200"></a>)</span>
+<span id="cb12-201"><a href="#cb12-201"></a>cs_scopes <span class="ot">&lt;-</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-202"><a href="#cb12-202"></a>  <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> names_scopes),</span>
+<span id="cb12-203"><a href="#cb12-203"></a>  <span class="at">selected =</span> names_scopes,</span>
+<span id="cb12-204"><a href="#cb12-204"></a>  <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-205"><a href="#cb12-205"></a>)</span>
+<span id="cb12-206"><a href="#cb12-206"></a></span>
+<span id="cb12-207"><a href="#cb12-207"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-208"><a href="#cb12-208"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-209"><a href="#cb12-209"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb12-210"><a href="#cb12-210"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb12-211"><a href="#cb12-211"></a>    ),</span>
+<span id="cb12-212"><a href="#cb12-212"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae,</span>
+<span id="cb12-213"><a href="#cb12-213"></a>      <span class="at">code =</span> <span class="st">'ADAE &lt;- synthetic_cdisc_dataset("latest", "adae")'</span></span>
+<span id="cb12-214"><a href="#cb12-214"></a>    ),</span>
+<span id="cb12-215"><a href="#cb12-215"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-216"><a href="#cb12-216"></a>  ),</span>
+<span id="cb12-217"><a href="#cb12-217"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-218"><a href="#cb12-218"></a>    <span class="fu">tm_t_smq</span>(</span>
+<span id="cb12-219"><a href="#cb12-219"></a>      <span class="at">label =</span> <span class="st">"Adverse Events by SMQ Table"</span>,</span>
+<span id="cb12-220"><a href="#cb12-220"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-221"><a href="#cb12-221"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-222"><a href="#cb12-222"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb12-223"><a href="#cb12-223"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-224"><a href="#cb12-224"></a>      ),</span>
+<span id="cb12-225"><a href="#cb12-225"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-226"><a href="#cb12-226"></a>      <span class="at">baskets =</span> cs_baskets,</span>
+<span id="cb12-227"><a href="#cb12-227"></a>      <span class="at">scopes =</span> cs_scopes,</span>
+<span id="cb12-228"><a href="#cb12-228"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-229"><a href="#cb12-229"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)),</span>
+<span id="cb12-230"><a href="#cb12-230"></a>        <span class="at">selected =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb12-231"><a href="#cb12-231"></a>      )</span>
+<span id="cb12-232"><a href="#cb12-232"></a>    )</span>
+<span id="cb12-233"><a href="#cb12-233"></a>  ),</span>
+<span id="cb12-234"><a href="#cb12-234"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADAE =</span> <span class="fu">list</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>))</span>
+<span id="cb12-235"><a href="#cb12-235"></a>)</span>
+<span id="cb12-236"><a href="#cb12-236"></a></span>
+<span id="cb12-237"><a href="#cb12-237"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-238"><a href="#cb12-238"></a><span class="in">```</span></span>
+<span id="cb12-239"><a href="#cb12-239"></a></span>
+<span id="cb12-240"><a href="#cb12-240"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-241"><a href="#cb12-241"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AET10</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Most Common (<span class="math inline">\(\geq\)</span> 5%) Adverse Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Most Common (<span class="math inline">\(\geq\)</span> 35%) Adverse Events (setting threshold)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aet10_cache/html/setup_ea7c593a5e38e8ab012af4a6fe6673d7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The “All Patients” column is not required in this table but for illustrative purposes we include it to show correct sorting.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aet10_cache/html/variant1_e2e6ca9543767ccb824d60b71d33e50e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-12"><a href="#cb2-12"></a>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">tt =</span> tbl1,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">prune_func =</span> <span class="fu">keep_rows</span>(</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="co"># specify threshold</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ARM)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    )</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  )</span>
+<span id="cb2-22"><a href="#cb2-22"></a>)</span>
+<span id="cb2-23"><a href="#cb2-23"></a></span>
+<span id="cb2-24"><a href="#cb2-24"></a>result <span class="ot">&lt;-</span> <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-25"><a href="#cb2-25"></a>  tbl2,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-28"><a href="#cb2-28"></a>)</span>
+<span id="cb2-29"><a href="#cb2-29"></a></span>
+<span id="cb2-30"><a href="#cb2-30"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                A: Drug X    B: Placebo   C: Combination   All Patients
+                 (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————
+dcd D.2.1.5.3   47 (35.1%)   58 (43.3%)     57 (43.2%)     162 (40.5%) 
+dcd A.1.1.1.1   50 (37.3%)   45 (33.6%)     63 (47.7%)     158 (39.5%) 
+dcd B.2.2.3.1   48 (35.8%)   54 (40.3%)     51 (38.6%)     153 (38.2%) 
+dcd A.1.1.1.2   48 (35.8%)   48 (35.8%)     50 (37.9%)     146 (36.5%) 
+dcd B.2.1.2.1   49 (36.6%)   44 (32.8%)     52 (39.4%)     145 (36.2%) 
+dcd D.1.1.1.1   50 (37.3%)   42 (31.3%)     51 (38.6%)     143 (35.8%) 
+dcd D.1.1.4.2   48 (35.8%)   42 (31.3%)     50 (37.9%)     140 (35.0%) 
+dcd B.1.1.1.1   47 (35.1%)   49 (36.6%)     43 (32.6%)     139 (34.8%) 
+dcd C.2.1.2.1   35 (26.1%)   48 (35.8%)     55 (41.7%)     138 (34.5%) 
+dcd C.1.1.1.3   43 (32.1%)   46 (34.3%)     43 (32.6%)     132 (33.0%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="aet10_cache/html/variant2_7a3e0caae3324066f96df4355d5528c6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-12"><a href="#cb4-12"></a>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="at">tt =</span> tbl1,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="at">prune_func =</span> <span class="fu">keep_rows</span>(</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb4-18"><a href="#cb4-18"></a>      <span class="at">atleast =</span> <span class="fl">0.35</span>, <span class="co"># specify threshold</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>      <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ARM)</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    )</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  )</span>
+<span id="cb4-22"><a href="#cb4-22"></a>)</span>
+<span id="cb4-23"><a href="#cb4-23"></a></span>
+<span id="cb4-24"><a href="#cb4-24"></a>result <span class="ot">&lt;-</span> <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>  tbl2,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>  <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-28"><a href="#cb4-28"></a>)</span>
+<span id="cb4-29"><a href="#cb4-29"></a></span>
+<span id="cb4-30"><a href="#cb4-30"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                A: Drug X    B: Placebo   C: Combination   All Patients
+                 (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————
+dcd D.2.1.5.3   47 (35.1%)   58 (43.3%)     57 (43.2%)     162 (40.5%) 
+dcd A.1.1.1.1   50 (37.3%)   45 (33.6%)     63 (47.7%)     158 (39.5%) 
+dcd B.2.2.3.1   48 (35.8%)   54 (40.3%)     51 (38.6%)     153 (38.2%) 
+dcd A.1.1.1.2   48 (35.8%)   48 (35.8%)     50 (37.9%)     146 (36.5%) 
+dcd B.2.1.2.1   49 (36.6%)   44 (32.8%)     52 (39.4%)     145 (36.2%) 
+dcd D.1.1.1.1   50 (37.3%)   42 (31.3%)     51 (38.6%)     143 (35.8%) 
+dcd D.1.1.4.2   48 (35.8%)   42 (31.3%)     50 (37.9%)     140 (35.0%) 
+dcd B.1.1.1.1   47 (35.1%)   49 (36.6%)     43 (32.6%)     139 (34.8%) 
+dcd C.2.1.2.1   35 (26.1%)   48 (35.8%)     55 (41.7%)     138 (34.5%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The desired frequency is specified in <code>prune_freq</code>. For illustration, frequency is set to <span class="math inline">\(\geq\)</span> 35%.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aet10_cache/html/teal_aeb821113ba35c3adc0193be89fec3f5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  ),</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-24"><a href="#cb6-24"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb6-26"><a href="#cb6-26"></a>      ),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-28"><a href="#cb6-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>      ),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span>,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">prune_freq =</span> <span class="dv">35</span>,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    )</span>
+<span id="cb6-35"><a href="#cb6-35"></a>  )</span>
+<span id="cb6-36"><a href="#cb6-36"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:15:27.6157 pid:10213 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aet10_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aet10_cache/html/sessioninfo_d2e290906facd46b801bc9c3e1c97dba">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aet10_cache/html/snapshot_d49dc702fddfcb5aca1e649ac6299a03">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/adverse-events/aet10.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
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+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
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+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
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+      localAlternateSentinel = value;
+    }
+  }
+  const getColorSchemeSentinel = () => {
+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
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+  // Ensure there is a toggle, if there isn't float one in the top right
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+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
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+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> AET10</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Most Common ($\geq$ 5%) Adverse Events</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-26"><a href="#cb12-26"></a><span class="in">```</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a></span>
+<span id="cb12-30"><a href="#cb12-30"></a>The "All Patients" column is not required in this table but for illustrative purposes we include it to show correct sorting.</span>
+<span id="cb12-31"><a href="#cb12-31"></a></span>
+<span id="cb12-32"><a href="#cb12-32"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb12-35"><a href="#cb12-35"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb12-36"><a href="#cb12-36"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb12-37"><a href="#cb12-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-39"><a href="#cb12-39"></a></span>
+<span id="cb12-40"><a href="#cb12-40"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-41"><a href="#cb12-41"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-42"><a href="#cb12-42"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb12-43"><a href="#cb12-43"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-44"><a href="#cb12-44"></a>)</span>
+<span id="cb12-45"><a href="#cb12-45"></a></span>
+<span id="cb12-46"><a href="#cb12-46"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(</span>
+<span id="cb12-47"><a href="#cb12-47"></a>  <span class="at">tt =</span> tbl1,</span>
+<span id="cb12-48"><a href="#cb12-48"></a>  <span class="at">prune_func =</span> <span class="fu">keep_rows</span>(</span>
+<span id="cb12-49"><a href="#cb12-49"></a>    <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb12-50"><a href="#cb12-50"></a>      <span class="at">atleast =</span> <span class="fl">0.05</span>, <span class="co"># specify threshold</span></span>
+<span id="cb12-51"><a href="#cb12-51"></a>      <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ARM)</span>
+<span id="cb12-52"><a href="#cb12-52"></a>    )</span>
+<span id="cb12-53"><a href="#cb12-53"></a>  )</span>
+<span id="cb12-54"><a href="#cb12-54"></a>)</span>
+<span id="cb12-55"><a href="#cb12-55"></a></span>
+<span id="cb12-56"><a href="#cb12-56"></a>result <span class="ot">&lt;-</span> <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-57"><a href="#cb12-57"></a>  tbl2,</span>
+<span id="cb12-58"><a href="#cb12-58"></a>  <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb12-59"><a href="#cb12-59"></a>  <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb12-60"><a href="#cb12-60"></a>)</span>
+<span id="cb12-61"><a href="#cb12-61"></a></span>
+<span id="cb12-62"><a href="#cb12-62"></a>result</span>
+<span id="cb12-63"><a href="#cb12-63"></a><span class="in">```</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a></span>
+<span id="cb12-65"><a href="#cb12-65"></a><span class="fu">## Most Common ($\geq$ 35%) Adverse Events (setting threshold)</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a></span>
+<span id="cb12-67"><a href="#cb12-67"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-69"><a href="#cb12-69"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb12-70"><a href="#cb12-70"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb12-71"><a href="#cb12-71"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb12-72"><a href="#cb12-72"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a>tbl1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-76"><a href="#cb12-76"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-77"><a href="#cb12-77"></a>  <span class="at">df =</span> adae,</span>
+<span id="cb12-78"><a href="#cb12-78"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-79"><a href="#cb12-79"></a>)</span>
+<span id="cb12-80"><a href="#cb12-80"></a></span>
+<span id="cb12-81"><a href="#cb12-81"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(</span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="at">tt =</span> tbl1,</span>
+<span id="cb12-83"><a href="#cb12-83"></a>  <span class="at">prune_func =</span> <span class="fu">keep_rows</span>(</span>
+<span id="cb12-84"><a href="#cb12-84"></a>    <span class="fu">has_fraction_in_any_col</span>(</span>
+<span id="cb12-85"><a href="#cb12-85"></a>      <span class="at">atleast =</span> <span class="fl">0.35</span>, <span class="co"># specify threshold</span></span>
+<span id="cb12-86"><a href="#cb12-86"></a>      <span class="at">col_names =</span> <span class="fu">levels</span>(adsl<span class="sc">$</span>ARM)</span>
+<span id="cb12-87"><a href="#cb12-87"></a>    )</span>
+<span id="cb12-88"><a href="#cb12-88"></a>  )</span>
+<span id="cb12-89"><a href="#cb12-89"></a>)</span>
+<span id="cb12-90"><a href="#cb12-90"></a></span>
+<span id="cb12-91"><a href="#cb12-91"></a>result <span class="ot">&lt;-</span> <span class="fu">sort_at_path</span>(</span>
+<span id="cb12-92"><a href="#cb12-92"></a>  tbl2,</span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>),</span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb12-95"><a href="#cb12-95"></a>)</span>
+<span id="cb12-96"><a href="#cb12-96"></a></span>
+<span id="cb12-97"><a href="#cb12-97"></a>result</span>
+<span id="cb12-98"><a href="#cb12-98"></a><span class="in">```</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a></span>
+<span id="cb12-100"><a href="#cb12-100"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-101"><a href="#cb12-101"></a></span>
+<span id="cb12-102"><a href="#cb12-102"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a></span>
+<span id="cb12-104"><a href="#cb12-104"></a>The desired frequency is specified in <span class="in">`prune_freq`</span>.</span>
+<span id="cb12-105"><a href="#cb12-105"></a>For illustration, frequency is set to $\geq$ 35%.</span>
+<span id="cb12-106"><a href="#cb12-106"></a></span>
+<span id="cb12-107"><a href="#cb12-107"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-108"><a href="#cb12-108"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb12-109"><a href="#cb12-109"></a></span>
+<span id="cb12-110"><a href="#cb12-110"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-111"><a href="#cb12-111"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-112"><a href="#cb12-112"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-113"><a href="#cb12-113"></a></span>
+<span id="cb12-114"><a href="#cb12-114"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-115"><a href="#cb12-115"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb12-116"><a href="#cb12-116"></a></span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-119"><a href="#cb12-119"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb12-120"><a href="#cb12-120"></a></span>
+<span id="cb12-121"><a href="#cb12-121"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb12-122"><a href="#cb12-122"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-123"><a href="#cb12-123"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb12-124"><a href="#cb12-124"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADAE"</span>, adae, <span class="at">code =</span> <span class="st">'ADAE &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adae"))'</span>),</span>
+<span id="cb12-125"><a href="#cb12-125"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-126"><a href="#cb12-126"></a>  ),</span>
+<span id="cb12-127"><a href="#cb12-127"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-128"><a href="#cb12-128"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb12-129"><a href="#cb12-129"></a>      <span class="at">label =</span> <span class="st">"Adverse Event Table"</span>,</span>
+<span id="cb12-130"><a href="#cb12-130"></a>      <span class="at">dataname =</span> <span class="st">"ADAE"</span>,</span>
+<span id="cb12-131"><a href="#cb12-131"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb12-132"><a href="#cb12-132"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-133"><a href="#cb12-133"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AETERM"</span>, <span class="st">"AEDECOD"</span>)),</span>
+<span id="cb12-134"><a href="#cb12-134"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AEDECOD"</span>)</span>
+<span id="cb12-135"><a href="#cb12-135"></a>      ),</span>
+<span id="cb12-136"><a href="#cb12-136"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-137"><a href="#cb12-137"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adae, <span class="fu">c</span>(<span class="st">"AEBODSYS"</span>, <span class="st">"AESOC"</span>)),</span>
+<span id="cb12-138"><a href="#cb12-138"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb12-139"><a href="#cb12-139"></a>      ),</span>
+<span id="cb12-140"><a href="#cb12-140"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-141"><a href="#cb12-141"></a>      <span class="at">event_type =</span> <span class="st">"adverse event"</span>,</span>
+<span id="cb12-142"><a href="#cb12-142"></a>      <span class="at">prune_freq =</span> <span class="dv">35</span>,</span>
+<span id="cb12-143"><a href="#cb12-143"></a>    )</span>
+<span id="cb12-144"><a href="#cb12-144"></a>  )</span>
+<span id="cb12-145"><a href="#cb12-145"></a>)</span>
+<span id="cb12-146"><a href="#cb12-146"></a></span>
+<span id="cb12-147"><a href="#cb12-147"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-148"><a href="#cb12-148"></a><span class="in">```</span></span>
+<span id="cb12-149"><a href="#cb12-149"></a></span>
+<span id="cb12-150"><a href="#cb12-150"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-151"><a href="#cb12-151"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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new file mode 100644
index 0000000000..5ad9d2b94c
--- /dev/null
+++ b/stable/tables/concomitant-medications/cmt01.html
@@ -0,0 +1,2613 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - CMT01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/concomitant-medications/cmt01a.html" rel="next">
+<link href="../../tables/adverse-events/aet10.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="../../site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="../../site_libs/quarto-html/quarto.js"></script>
+<script src="../../site_libs/quarto-html/popper.min.js"></script>
+<script src="../../site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CMT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Concomitant Medications (GNEDrug Legacy Coding)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Showing Medications Prior <br> to the Start of the Study</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Sorted by Total Column Showing <br> Additional “All Patients” Column</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cmt01_cache/html/setup_998dd9e24dc508c9e6ae4758034aad75">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="co"># The following tables require ADCM data structure that follows the legacy concomitant medication coding. WHO coding is not used.</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Below step is to set up example data based on legacy standard.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">select</span>(<span class="sc">-</span><span class="fu">starts_with</span>(<span class="st">"ATC"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">unique</span>()</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adcm_con <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>adcm_prior <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"PRIOR"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cmt01_cache/html/variant1_6a8bdb4de06b20687e7d395a684cfc89">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>    )</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>    )</span>
+<span id="cb2-29"><a href="#cb2-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-32"><a href="#cb2-32"></a></span>
+<span id="cb2-33"><a href="#cb2-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-37"><a href="#cb2-37"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-42"><a href="#cb2-42"></a>  )</span>
+<span id="cb2-43"><a href="#cb2-43"></a></span>
+<span id="cb2-44"><a href="#cb2-44"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Medication Class                                            A: Drug X    B: Placebo    C: Combination
+  Standardized Medication Name                               (N=134)       (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment       117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                     415           414            460      
+  medcl A                                                                                            
+    Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+    Total number of treatments                                 134           137            143      
+    medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+  medcl B                                                                                            
+    Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+    Total number of treatments                                 141           137            162      
+    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+    medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+  medcl C                                                                                            
+    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+    Total number of treatments                                 140           140            155      
+    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="cmt01_cache/html/variant2_55d43456e08369196cd3c5423488251a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>    )</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>    )</span>
+<span id="cb4-25"><a href="#cb4-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="fu">append_varlabels</span>(adcm_prior, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-28"><a href="#cb4-28"></a></span>
+<span id="cb4-29"><a href="#cb4-29"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="at">df =</span> adcm_prior,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-33"><a href="#cb4-33"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  )</span>
+<span id="cb4-39"><a href="#cb4-39"></a></span>
+<span id="cb4-40"><a href="#cb4-40"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Medication Class                                         A: Drug X    B: Placebo   C: Combination
+  Standardized Medication Name                            (N=134)      (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     89 (66.4%)   95 (70.9%)    106 (80.3%)  
+Total number of treatments                                  194          208            243      
+medcl A                                                                                          
+  Total number of patients with at least one treatment   54 (40.3%)   49 (36.6%)     69 (52.3%)  
+  Total number of treatments                                 71           70             99      
+  medname A_1/3                                          54 (40.3%)   49 (36.6%)     69 (52.3%)  
+medcl B                                                                                          
+  Total number of patients with at least one treatment   76 (56.7%)   80 (59.7%)     81 (61.4%)  
+  Total number of treatments                                123          138            144      
+  medname B_2/4                                          52 (38.8%)   55 (41.0%)     56 (42.4%)  
+  medname B_3/4                                          47 (35.1%)   47 (35.1%)     52 (39.4%)  </code></pre>
+</div>
+</div>
+<p>Table with Subtotal Per <br> Medication Class Suppressed</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="cmt01_cache/html/variant3_c68501fb8ebfbee86b2b99eb16d6d25d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>    )</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">split_fun =</span> split_fun, <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb6-16"><a href="#cb6-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb6-24"><a href="#cb6-24"></a></span>
+<span id="cb6-25"><a href="#cb6-25"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb6-29"><a href="#cb6-29"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb6-34"><a href="#cb6-34"></a>  )</span>
+<span id="cb6-35"><a href="#cb6-35"></a></span>
+<span id="cb6-36"><a href="#cb6-36"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Medication Class                                          A: Drug X    B: Placebo    C: Combination
+  Standardized Medication Name                             (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                   415           414            460      
+medcl A                                                                                            
+  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+medcl B                                                                                            
+  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+medcl C                                                                                            
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="cmt01_cache/html/variant4_ed9e2e8a7a5eea390f1474807e78cf22">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-8"><a href="#cb8-8"></a>      <span class="st">"Total number of patients with at least one treatment (%)"</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>      <span class="st">"Total number of treatments"</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>    )</span>
+<span id="cb8-11"><a href="#cb8-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-13"><a href="#cb8-13"></a>    <span class="st">"CMCLAS"</span>,</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb8-19"><a href="#cb8-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-20"><a href="#cb8-20"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-23"><a href="#cb8-23"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-24"><a href="#cb8-24"></a>      <span class="st">"Total number of patients with at least one treatment (%)"</span>,</span>
+<span id="cb8-25"><a href="#cb8-25"></a>      <span class="st">"Total number of treatments"</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>    )</span>
+<span id="cb8-27"><a href="#cb8-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb8-30"><a href="#cb8-30"></a></span>
+<span id="cb8-31"><a href="#cb8-31"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb8-35"><a href="#cb8-35"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>),</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  )</span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Medication Class                                              A: Drug X    B: Placebo    C: Combination   All Patients
+  Standardized Medication Name                                 (N=134)       (N=134)        (N=132)         (N=400)   
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment (%)     117 (87.3%)   116 (86.6%)    116 (87.9%)     349 (87.2%) 
+Total number of treatments                                       415           414            460             1289    
+medcl C                                                                                                               
+  Total number of patients with at least one treatment (%)   82 (61.2%)    84 (62.7%)      89 (67.4%)     255 (63.7%) 
+  Total number of treatments                                     140           140            155             435     
+  medname C_2/2                                              52 (38.8%)    58 (43.3%)      60 (45.5%)     170 (42.5%) 
+  medname C_1/2                                              51 (38.1%)    50 (37.3%)      56 (42.4%)     157 (39.2%) 
+medcl B                                                                                                               
+  Total number of patients with at least one treatment (%)   83 (61.9%)    74 (55.2%)      88 (66.7%)     245 (61.3%) 
+  Total number of treatments                                     141           137            162             440     
+  medname B_1/4                                              52 (38.8%)    57 (42.5%)      59 (44.7%)     168 (42.0%) 
+  medname B_4/4                                              50 (37.3%)    45 (33.6%)      55 (41.7%)     150 (37.5%) 
+medcl A                                                                                                               
+  Total number of patients with at least one treatment (%)   75 (56.0%)    79 (59.0%)      81 (61.4%)     235 (58.8%) 
+  Total number of treatments                                     134           137            143             414     
+  medname A_2/3                                              53 (39.6%)    50 (37.3%)      56 (42.4%)     159 (39.8%) 
+  medname A_3/3                                              45 (33.6%)    54 (40.3%)      48 (36.4%)     147 (36.8%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Here, <code>adcm</code> is processed to keep only one path per treatment.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="cmt01_cache/html/teal_412409ff04f23bdc0fb10ae0aadbad24">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-9"><a href="#cb10-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-10"><a href="#cb10-10"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb10-11"><a href="#cb10-11"></a></span>
+<span id="cb10-12"><a href="#cb10-12"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb10-13"><a href="#cb10-13"></a>  <span class="fu">group_by</span>(STUDYID, USUBJID, CMDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb10-16"><a href="#cb10-16"></a></span>
+<span id="cb10-17"><a href="#cb10-17"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb10-18"><a href="#cb10-18"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-19"><a href="#cb10-19"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb10-20"><a href="#cb10-20"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      adsl,</span>
+<span id="cb10-22"><a href="#cb10-22"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>    ),</span>
+<span id="cb10-24"><a href="#cb10-24"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>      <span class="st">"ADCM"</span>,</span>
+<span id="cb10-26"><a href="#cb10-26"></a>      adcm,</span>
+<span id="cb10-27"><a href="#cb10-27"></a>      <span class="at">code =</span> <span class="st">'ADCM &lt;- df_explicit_na(</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="st">      synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a><span class="st">      ) %&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="st">        group_by(STUDYID, USUBJID, CMDECOD) %&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a><span class="st">        slice(1) %&gt;%</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a><span class="st">        ungroup'</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"CMDECOD"</span>)</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    )</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  ),</span>
+<span id="cb10-36"><a href="#cb10-36"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-37"><a href="#cb10-37"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medication Table"</span>,</span>
+<span id="cb10-39"><a href="#cb10-39"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-41"><a href="#cb10-41"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb10-43"><a href="#cb10-43"></a>        <span class="at">selected =</span> <span class="st">"CMDECOD"</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>      ),</span>
+<span id="cb10-45"><a href="#cb10-45"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-46"><a href="#cb10-46"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="st">"CMCLAS"</span>),</span>
+<span id="cb10-47"><a href="#cb10-47"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>)</span>
+<span id="cb10-48"><a href="#cb10-48"></a>      ),</span>
+<span id="cb10-49"><a href="#cb10-49"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>    )</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  )</span>
+<span id="cb10-53"><a href="#cb10-53"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:07:53.4451 pid:8721 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cmt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cmt01_cache/html/sessioninfo_658e548792049d4aad1b89e6bf3971ff">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cmt01_cache/html/snapshot_383d262c5f5f99fb832d4b447ec8c04d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/concomitant-medications/cmt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+          }
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+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/adverse-events/aet10.html" class="pagination-link">
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+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/concomitant-medications/cmt01a.html" class="pagination-link">
+        <span class="nav-page-text">CMT01A</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> CMT01</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Concomitant Medications (GNEDrug Legacy Coding)</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a><span class="co"># The following tables require ADCM data structure that follows the legacy concomitant medication coding. WHO coding is not used.</span></span>
+<span id="cb16-21"><a href="#cb16-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb16-23"><a href="#cb16-23"></a></span>
+<span id="cb16-24"><a href="#cb16-24"></a><span class="co"># Below step is to set up example data based on legacy standard.</span></span>
+<span id="cb16-25"><a href="#cb16-25"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb16-26"><a href="#cb16-26"></a>  <span class="fu">select</span>(<span class="sc">-</span><span class="fu">starts_with</span>(<span class="st">"ATC"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-27"><a href="#cb16-27"></a>  <span class="fu">unique</span>()</span>
+<span id="cb16-28"><a href="#cb16-28"></a></span>
+<span id="cb16-29"><a href="#cb16-29"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-30"><a href="#cb16-30"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-31"><a href="#cb16-31"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb16-32"><a href="#cb16-32"></a></span>
+<span id="cb16-33"><a href="#cb16-33"></a>adcm_con <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb16-34"><a href="#cb16-34"></a>  <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb16-35"><a href="#cb16-35"></a></span>
+<span id="cb16-36"><a href="#cb16-36"></a>adcm_prior <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb16-37"><a href="#cb16-37"></a>  <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"PRIOR"</span>)</span>
+<span id="cb16-38"><a href="#cb16-38"></a><span class="in">```</span></span>
+<span id="cb16-39"><a href="#cb16-39"></a></span>
+<span id="cb16-40"><a href="#cb16-40"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-41"><a href="#cb16-41"></a></span>
+<span id="cb16-42"><a href="#cb16-42"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-43"><a href="#cb16-43"></a><span class="co"># Define the split function</span></span>
+<span id="cb16-44"><a href="#cb16-44"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-45"><a href="#cb16-45"></a></span>
+<span id="cb16-46"><a href="#cb16-46"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-47"><a href="#cb16-47"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-48"><a href="#cb16-48"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-49"><a href="#cb16-49"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-50"><a href="#cb16-50"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-51"><a href="#cb16-51"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-52"><a href="#cb16-52"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-53"><a href="#cb16-53"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-54"><a href="#cb16-54"></a>    )</span>
+<span id="cb16-55"><a href="#cb16-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-56"><a href="#cb16-56"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb16-57"><a href="#cb16-57"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-59"><a href="#cb16-59"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-60"><a href="#cb16-60"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb16-61"><a href="#cb16-61"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-62"><a href="#cb16-62"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb16-63"><a href="#cb16-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-64"><a href="#cb16-64"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-65"><a href="#cb16-65"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-66"><a href="#cb16-66"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-67"><a href="#cb16-67"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-68"><a href="#cb16-68"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-69"><a href="#cb16-69"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-70"><a href="#cb16-70"></a>    )</span>
+<span id="cb16-71"><a href="#cb16-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-72"><a href="#cb16-72"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-73"><a href="#cb16-73"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-74"><a href="#cb16-74"></a></span>
+<span id="cb16-75"><a href="#cb16-75"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb16-76"><a href="#cb16-76"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb16-77"><a href="#cb16-77"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb16-78"><a href="#cb16-78"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb16-79"><a href="#cb16-79"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-80"><a href="#cb16-80"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-81"><a href="#cb16-81"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-82"><a href="#cb16-82"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-83"><a href="#cb16-83"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-84"><a href="#cb16-84"></a>  )</span>
+<span id="cb16-85"><a href="#cb16-85"></a></span>
+<span id="cb16-86"><a href="#cb16-86"></a>result</span>
+<span id="cb16-87"><a href="#cb16-87"></a><span class="in">```</span></span>
+<span id="cb16-88"><a href="#cb16-88"></a></span>
+<span id="cb16-89"><a href="#cb16-89"></a><span class="fu">## Table Showing Medications Prior &lt;br/&gt; to the Start of the Study</span></span>
+<span id="cb16-90"><a href="#cb16-90"></a></span>
+<span id="cb16-91"><a href="#cb16-91"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-93"><a href="#cb16-93"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-94"><a href="#cb16-94"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-95"><a href="#cb16-95"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-96"><a href="#cb16-96"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-97"><a href="#cb16-97"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-98"><a href="#cb16-98"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-99"><a href="#cb16-99"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-100"><a href="#cb16-100"></a>    )</span>
+<span id="cb16-101"><a href="#cb16-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-102"><a href="#cb16-102"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb16-103"><a href="#cb16-103"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-104"><a href="#cb16-104"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-105"><a href="#cb16-105"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-106"><a href="#cb16-106"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-107"><a href="#cb16-107"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb16-108"><a href="#cb16-108"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-110"><a href="#cb16-110"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-111"><a href="#cb16-111"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-112"><a href="#cb16-112"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-113"><a href="#cb16-113"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-114"><a href="#cb16-114"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-115"><a href="#cb16-115"></a>    )</span>
+<span id="cb16-116"><a href="#cb16-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-117"><a href="#cb16-117"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-118"><a href="#cb16-118"></a>  <span class="fu">append_varlabels</span>(adcm_prior, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-119"><a href="#cb16-119"></a></span>
+<span id="cb16-120"><a href="#cb16-120"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb16-121"><a href="#cb16-121"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb16-122"><a href="#cb16-122"></a>  <span class="at">df =</span> adcm_prior,</span>
+<span id="cb16-123"><a href="#cb16-123"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb16-124"><a href="#cb16-124"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-125"><a href="#cb16-125"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-126"><a href="#cb16-126"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-127"><a href="#cb16-127"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-128"><a href="#cb16-128"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-129"><a href="#cb16-129"></a>  )</span>
+<span id="cb16-130"><a href="#cb16-130"></a></span>
+<span id="cb16-131"><a href="#cb16-131"></a>result</span>
+<span id="cb16-132"><a href="#cb16-132"></a><span class="in">```</span></span>
+<span id="cb16-133"><a href="#cb16-133"></a></span>
+<span id="cb16-134"><a href="#cb16-134"></a>Table with Subtotal Per <span class="kw">&lt;br/&gt;</span> Medication Class Suppressed</span>
+<span id="cb16-135"><a href="#cb16-135"></a></span>
+<span id="cb16-136"><a href="#cb16-136"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-137"><a href="#cb16-137"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-138"><a href="#cb16-138"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-139"><a href="#cb16-139"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-140"><a href="#cb16-140"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-141"><a href="#cb16-141"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-142"><a href="#cb16-142"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-143"><a href="#cb16-143"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-144"><a href="#cb16-144"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-145"><a href="#cb16-145"></a>    )</span>
+<span id="cb16-146"><a href="#cb16-146"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-147"><a href="#cb16-147"></a>  <span class="fu">split_rows_by</span>(<span class="st">"CMCLAS"</span>,</span>
+<span id="cb16-148"><a href="#cb16-148"></a>    <span class="at">split_fun =</span> split_fun, <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-149"><a href="#cb16-149"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-150"><a href="#cb16-150"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-151"><a href="#cb16-151"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb16-152"><a href="#cb16-152"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-153"><a href="#cb16-153"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-154"><a href="#cb16-154"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-155"><a href="#cb16-155"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>),</span>
+<span id="cb16-156"><a href="#cb16-156"></a>    <span class="at">.stats =</span> <span class="st">"unique"</span></span>
+<span id="cb16-157"><a href="#cb16-157"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-159"><a href="#cb16-159"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-160"><a href="#cb16-160"></a></span>
+<span id="cb16-161"><a href="#cb16-161"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb16-162"><a href="#cb16-162"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb16-163"><a href="#cb16-163"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb16-164"><a href="#cb16-164"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb16-165"><a href="#cb16-165"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-167"><a href="#cb16-167"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-168"><a href="#cb16-168"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-169"><a href="#cb16-169"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-170"><a href="#cb16-170"></a>  )</span>
+<span id="cb16-171"><a href="#cb16-171"></a></span>
+<span id="cb16-172"><a href="#cb16-172"></a>result</span>
+<span id="cb16-173"><a href="#cb16-173"></a><span class="in">```</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a></span>
+<span id="cb16-175"><a href="#cb16-175"></a><span class="fu">## Table Sorted by Total Column Showing &lt;br/&gt; Additional "All Patients" Column</span></span>
+<span id="cb16-176"><a href="#cb16-176"></a></span>
+<span id="cb16-177"><a href="#cb16-177"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-178"><a href="#cb16-178"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-179"><a href="#cb16-179"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-180"><a href="#cb16-180"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-181"><a href="#cb16-181"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-182"><a href="#cb16-182"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-183"><a href="#cb16-183"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-184"><a href="#cb16-184"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-185"><a href="#cb16-185"></a>      <span class="st">"Total number of patients with at least one treatment (%)"</span>,</span>
+<span id="cb16-186"><a href="#cb16-186"></a>      <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-187"><a href="#cb16-187"></a>    )</span>
+<span id="cb16-188"><a href="#cb16-188"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-189"><a href="#cb16-189"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-190"><a href="#cb16-190"></a>    <span class="st">"CMCLAS"</span>,</span>
+<span id="cb16-191"><a href="#cb16-191"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-192"><a href="#cb16-192"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-193"><a href="#cb16-193"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-194"><a href="#cb16-194"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-195"><a href="#cb16-195"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm_con<span class="sc">$</span>CMCLAS)</span>
+<span id="cb16-196"><a href="#cb16-196"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-197"><a href="#cb16-197"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-198"><a href="#cb16-198"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-199"><a href="#cb16-199"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-200"><a href="#cb16-200"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-201"><a href="#cb16-201"></a>      <span class="st">"Total number of patients with at least one treatment (%)"</span>,</span>
+<span id="cb16-202"><a href="#cb16-202"></a>      <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-203"><a href="#cb16-203"></a>    )</span>
+<span id="cb16-204"><a href="#cb16-204"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-205"><a href="#cb16-205"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-206"><a href="#cb16-206"></a>  <span class="fu">append_varlabels</span>(adcm_con, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-207"><a href="#cb16-207"></a></span>
+<span id="cb16-208"><a href="#cb16-208"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb16-209"><a href="#cb16-209"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb16-210"><a href="#cb16-210"></a>  <span class="at">df =</span> adcm_con,</span>
+<span id="cb16-211"><a href="#cb16-211"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb16-212"><a href="#cb16-212"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-213"><a href="#cb16-213"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-214"><a href="#cb16-214"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-215"><a href="#cb16-215"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-216"><a href="#cb16-216"></a>    <span class="at">scorefun =</span> score_occurrences,</span>
+<span id="cb16-217"><a href="#cb16-217"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-218"><a href="#cb16-218"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-219"><a href="#cb16-219"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-220"><a href="#cb16-220"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>),</span>
+<span id="cb16-221"><a href="#cb16-221"></a>    <span class="at">scorefun =</span> cont_n_allcols,</span>
+<span id="cb16-222"><a href="#cb16-222"></a>    <span class="at">decreasing =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-223"><a href="#cb16-223"></a>  )</span>
+<span id="cb16-224"><a href="#cb16-224"></a></span>
+<span id="cb16-225"><a href="#cb16-225"></a>result</span>
+<span id="cb16-226"><a href="#cb16-226"></a><span class="in">```</span></span>
+<span id="cb16-227"><a href="#cb16-227"></a></span>
+<span id="cb16-228"><a href="#cb16-228"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-229"><a href="#cb16-229"></a></span>
+<span id="cb16-230"><a href="#cb16-230"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-231"><a href="#cb16-231"></a></span>
+<span id="cb16-232"><a href="#cb16-232"></a>Here, <span class="in">`adcm`</span> is processed to keep only one path per treatment.</span>
+<span id="cb16-233"><a href="#cb16-233"></a></span>
+<span id="cb16-234"><a href="#cb16-234"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-235"><a href="#cb16-235"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb16-236"><a href="#cb16-236"></a></span>
+<span id="cb16-237"><a href="#cb16-237"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-238"><a href="#cb16-238"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-239"><a href="#cb16-239"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-240"><a href="#cb16-240"></a></span>
+<span id="cb16-241"><a href="#cb16-241"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-242"><a href="#cb16-242"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb16-243"><a href="#cb16-243"></a></span>
+<span id="cb16-244"><a href="#cb16-244"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-245"><a href="#cb16-245"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-246"><a href="#cb16-246"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb16-247"><a href="#cb16-247"></a></span>
+<span id="cb16-248"><a href="#cb16-248"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb16-249"><a href="#cb16-249"></a>  <span class="fu">group_by</span>(STUDYID, USUBJID, CMDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb16-250"><a href="#cb16-250"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-251"><a href="#cb16-251"></a>  <span class="fu">ungroup</span>()</span>
+<span id="cb16-252"><a href="#cb16-252"></a></span>
+<span id="cb16-253"><a href="#cb16-253"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb16-254"><a href="#cb16-254"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-255"><a href="#cb16-255"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb16-256"><a href="#cb16-256"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb16-257"><a href="#cb16-257"></a>      adsl,</span>
+<span id="cb16-258"><a href="#cb16-258"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb16-259"><a href="#cb16-259"></a>    ),</span>
+<span id="cb16-260"><a href="#cb16-260"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb16-261"><a href="#cb16-261"></a>      <span class="st">"ADCM"</span>,</span>
+<span id="cb16-262"><a href="#cb16-262"></a>      adcm,</span>
+<span id="cb16-263"><a href="#cb16-263"></a>      <span class="at">code =</span> <span class="st">'ADCM &lt;- df_explicit_na(</span></span>
+<span id="cb16-264"><a href="#cb16-264"></a><span class="st">      synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb16-265"><a href="#cb16-265"></a><span class="st">      ) %&gt;%</span></span>
+<span id="cb16-266"><a href="#cb16-266"></a><span class="st">        group_by(STUDYID, USUBJID, CMDECOD) %&gt;%</span></span>
+<span id="cb16-267"><a href="#cb16-267"></a><span class="st">        slice(1) %&gt;%</span></span>
+<span id="cb16-268"><a href="#cb16-268"></a><span class="st">        ungroup'</span>,</span>
+<span id="cb16-269"><a href="#cb16-269"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"CMDECOD"</span>)</span>
+<span id="cb16-270"><a href="#cb16-270"></a>    )</span>
+<span id="cb16-271"><a href="#cb16-271"></a>  ),</span>
+<span id="cb16-272"><a href="#cb16-272"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-273"><a href="#cb16-273"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb16-274"><a href="#cb16-274"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medication Table"</span>,</span>
+<span id="cb16-275"><a href="#cb16-275"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb16-276"><a href="#cb16-276"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb16-277"><a href="#cb16-277"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-278"><a href="#cb16-278"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-279"><a href="#cb16-279"></a>        <span class="at">selected =</span> <span class="st">"CMDECOD"</span></span>
+<span id="cb16-280"><a href="#cb16-280"></a>      ),</span>
+<span id="cb16-281"><a href="#cb16-281"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-282"><a href="#cb16-282"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="st">"CMCLAS"</span>),</span>
+<span id="cb16-283"><a href="#cb16-283"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMCLAS"</span>)</span>
+<span id="cb16-284"><a href="#cb16-284"></a>      ),</span>
+<span id="cb16-285"><a href="#cb16-285"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-286"><a href="#cb16-286"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb16-287"><a href="#cb16-287"></a>    )</span>
+<span id="cb16-288"><a href="#cb16-288"></a>  )</span>
+<span id="cb16-289"><a href="#cb16-289"></a>)</span>
+<span id="cb16-290"><a href="#cb16-290"></a></span>
+<span id="cb16-291"><a href="#cb16-291"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-292"><a href="#cb16-292"></a><span class="in">```</span></span>
+<span id="cb16-293"><a href="#cb16-293"></a></span>
+<span id="cb16-294"><a href="#cb16-294"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-295"><a href="#cb16-295"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
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\ No newline at end of file
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+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="true">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+        <li class="sidebar-item">
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+<div class="quarto-title-block"><div><h1 class="title">CMT01A</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Concomitant Medications by Medication Class and Preferred Name</p>
+</div>
+
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+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table, <br> Safety-Evaluable Patients</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Changing <br> ATC Class Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Classes <br> Sorted by Frequency</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Total Number of Treatments <br> per Medication Class Suppressed</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cmt01a_cache/html/setup_8dc02fbf2a68b4a5d2ffdafc70abffc3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">var_relabel</span>(<span class="at">CMDECOD =</span> <span class="st">"Other Treatment"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cmt01a_cache/html/variant1_71a7f09b4e5c4dad71873d7e0d563b24">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>    )</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>    )</span>
+<span id="cb2-30"><a href="#cb2-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-33"><a href="#cb2-33"></a></span>
+<span id="cb2-34"><a href="#cb2-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-40"><a href="#cb2-40"></a>  )</span>
+<span id="cb2-41"><a href="#cb2-41"></a></span>
+<span id="cb2-42"><a href="#cb2-42"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination
+  Other Treatment                                          (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                   415           414            460      
+ATCCLAS2 A                                                                                         
+  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+  Total number of treatments                                 134           137            143      
+  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS2 A p2                                                                                      
+  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+  Total number of treatments                                 58            66              64      
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS2 B                                                                                         
+  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+  Total number of treatments                                 141           137            162      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS2 B p2                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 B p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 C                                                                                         
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 C p2                                                                                      
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 C p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  Total number of treatments                                 69            73              80      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="cmt01a_cache/html/variant2_bf84917621b2dda946891ed004294459">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>    )</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>    )</span>
+<span id="cb4-30"><a href="#cb4-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-33"><a href="#cb4-33"></a></span>
+<span id="cb4-34"><a href="#cb4-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-36"><a href="#cb4-36"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-40"><a href="#cb4-40"></a>  )</span>
+<span id="cb4-41"><a href="#cb4-41"></a></span>
+<span id="cb4-42"><a href="#cb4-42"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 1 Text                                          A: Drug X    B: Placebo    C: Combination
+  Other Treatment                                          (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                   415           414            460      
+ATCCLAS1 A                                                                                         
+  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+  Total number of treatments                                 134           137            143      
+  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS1 A p2                                                                                      
+  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+  Total number of treatments                                 58            66              64      
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS1 B                                                                                         
+  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+  Total number of treatments                                 141           137            162      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS1 B p2                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS1 B p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS1 C                                                                                         
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS1 C p2                                                                                      
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS1 C p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  Total number of treatments                                 69            73              80      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="cmt01a_cache/html/variant3_e0e92115e99fc3f38894b49cd5a132c7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb6-11"><a href="#cb6-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>    )</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb6-21"><a href="#cb6-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>    )</span>
+<span id="cb6-30"><a href="#cb6-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb6-33"><a href="#cb6-33"></a></span>
+<span id="cb6-34"><a href="#cb6-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>), <span class="at">scorefun =</span> score_occurrences)</span>
+<span id="cb6-38"><a href="#cb6-38"></a></span>
+<span id="cb6-39"><a href="#cb6-39"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination
+  Other Treatment                                          (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                   415           414            460      
+ATCCLAS2 C                                                                                         
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 C p2                                                                                      
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  Total number of treatments                                 140           140            155      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 B                                                                                         
+  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+  Total number of treatments                                 141           137            162      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS2 A                                                                                         
+  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+  Total number of treatments                                 134           137            143      
+  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS2 C p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  Total number of treatments                                 69            73              80      
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+ATCCLAS2 B p2                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 B p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  Total number of treatments                                 75            82              83      
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 A p2                                                                                      
+  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+  Total number of treatments                                 58            66              64      
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="cmt01a_cache/html/variant4_c63ed12b19ecae5e6d02ae1b71e272dc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>    )</span>
+<span id="cb8-13"><a href="#cb8-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-23"><a href="#cb8-23"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-24"><a href="#cb8-24"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb8-26"><a href="#cb8-26"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-27"><a href="#cb8-27"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>    )</span>
+<span id="cb8-29"><a href="#cb8-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb8-39"><a href="#cb8-39"></a>  )</span>
+<span id="cb8-40"><a href="#cb8-40"></a></span>
+<span id="cb8-41"><a href="#cb8-41"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination
+  Other Treatment                                          (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment     117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                   415           414            460      
+ATCCLAS2 A                                                                                         
+  Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+  medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS2 A p2                                                                                      
+  Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+  medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS2 B                                                                                         
+  Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS2 B p2                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 B p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+  medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS2 C                                                                                         
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 C p2                                                                                      
+  Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS2 C p3                                                                                      
+  Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+  medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="cmt01a_cache/html/teal_6e9a242817a8a6c2aaee20daf392b3fb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb10-8"><a href="#cb10-8"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-15"><a href="#cb10-15"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb10-16"><a href="#cb10-16"></a></span>
+<span id="cb10-17"><a href="#cb10-17"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb10-18"><a href="#cb10-18"></a></span>
+<span id="cb10-19"><a href="#cb10-19"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb10-20"><a href="#cb10-20"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-21"><a href="#cb10-21"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a><span class="st">                  '</span>),</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb10-26"><a href="#cb10-26"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="st">      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="st">      '</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    )</span>
+<span id="cb10-33"><a href="#cb10-33"></a>  ),</span>
+<span id="cb10-34"><a href="#cb10-34"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb10-36"><a href="#cb10-36"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb10-37"><a href="#cb10-37"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-39"><a href="#cb10-39"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb10-40"><a href="#cb10-40"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb10-42"><a href="#cb10-42"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>)</span>
+<span id="cb10-43"><a href="#cb10-43"></a>      ),</span>
+<span id="cb10-44"><a href="#cb10-44"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-45"><a href="#cb10-45"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb10-46"><a href="#cb10-46"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb10-47"><a href="#cb10-47"></a>      ),</span>
+<span id="cb10-48"><a href="#cb10-48"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>    )</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  ),</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  )</span>
+<span id="cb10-56"><a href="#cb10-56"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:09:43.1409 pid:9017 token:[] teal.modules.clinical Initializing tm_t_mult_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cmt01a_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cmt01a_cache/html/sessioninfo_088f60dad18c52247c152e7ce5201c4d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cmt01a_cache/html/snapshot_6eca6ff8a50128f5e669bfe9d977df57">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/concomitant-medications/cmt01a.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
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+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
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+      stylesheet.rel = 'stylesheet';
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+  const manageTransitions = (selector, allowTransitions) => {
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+      } else {
+        el.classList.add('notransition');
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+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
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+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
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+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+      window.localStorage.setItem("quarto-color-scheme", value);
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+    }
+  }
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+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
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+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
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+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+        return true;
+      }
+    }
+    return false;
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+      <a href="../../tables/concomitant-medications/cmt01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CMT01</span>
+      </a>          
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+  <div class="nav-page nav-page-next">
+      <a href="../../tables/concomitant-medications/cmt01b.html" class="pagination-link">
+        <span class="nav-page-text">CMT01B</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> CMT01A</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Concomitant Medications by Medication Class and Preferred Name</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-21"><a href="#cb16-21"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb16-24"><a href="#cb16-24"></a></span>
+<span id="cb16-25"><a href="#cb16-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-26"><a href="#cb16-26"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb16-27"><a href="#cb16-27"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb16-29"><a href="#cb16-29"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-30"><a href="#cb16-30"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb16-31"><a href="#cb16-31"></a></span>
+<span id="cb16-32"><a href="#cb16-32"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb16-33"><a href="#cb16-33"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-34"><a href="#cb16-34"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-35"><a href="#cb16-35"></a></span>
+<span id="cb16-36"><a href="#cb16-36"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb16-37"><a href="#cb16-37"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-38"><a href="#cb16-38"></a>  <span class="fu">var_relabel</span>(<span class="at">CMDECOD =</span> <span class="st">"Other Treatment"</span>)</span>
+<span id="cb16-39"><a href="#cb16-39"></a><span class="in">```</span></span>
+<span id="cb16-40"><a href="#cb16-40"></a></span>
+<span id="cb16-41"><a href="#cb16-41"></a><span class="fu">## Standard Table, &lt;br/&gt; Safety-Evaluable Patients</span></span>
+<span id="cb16-42"><a href="#cb16-42"></a></span>
+<span id="cb16-43"><a href="#cb16-43"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-44"><a href="#cb16-44"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-45"><a href="#cb16-45"></a></span>
+<span id="cb16-46"><a href="#cb16-46"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-47"><a href="#cb16-47"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-48"><a href="#cb16-48"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-49"><a href="#cb16-49"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-50"><a href="#cb16-50"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-51"><a href="#cb16-51"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-52"><a href="#cb16-52"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-53"><a href="#cb16-53"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-54"><a href="#cb16-54"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-55"><a href="#cb16-55"></a>    )</span>
+<span id="cb16-56"><a href="#cb16-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-57"><a href="#cb16-57"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb16-59"><a href="#cb16-59"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-60"><a href="#cb16-60"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-61"><a href="#cb16-61"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-62"><a href="#cb16-62"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-63"><a href="#cb16-63"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb16-64"><a href="#cb16-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-65"><a href="#cb16-65"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-66"><a href="#cb16-66"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-67"><a href="#cb16-67"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-68"><a href="#cb16-68"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-69"><a href="#cb16-69"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-70"><a href="#cb16-70"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-71"><a href="#cb16-71"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-72"><a href="#cb16-72"></a>    )</span>
+<span id="cb16-73"><a href="#cb16-73"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-74"><a href="#cb16-74"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-76"><a href="#cb16-76"></a></span>
+<span id="cb16-77"><a href="#cb16-77"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-78"><a href="#cb16-78"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-79"><a href="#cb16-79"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb16-80"><a href="#cb16-80"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-81"><a href="#cb16-81"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-82"><a href="#cb16-82"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-83"><a href="#cb16-83"></a>  )</span>
+<span id="cb16-84"><a href="#cb16-84"></a></span>
+<span id="cb16-85"><a href="#cb16-85"></a>result</span>
+<span id="cb16-86"><a href="#cb16-86"></a><span class="in">```</span></span>
+<span id="cb16-87"><a href="#cb16-87"></a></span>
+<span id="cb16-88"><a href="#cb16-88"></a><span class="fu">## Table Changing &lt;br/&gt; ATC Class Level</span></span>
+<span id="cb16-89"><a href="#cb16-89"></a></span>
+<span id="cb16-90"><a href="#cb16-90"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-91"><a href="#cb16-91"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-92"><a href="#cb16-92"></a></span>
+<span id="cb16-93"><a href="#cb16-93"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-94"><a href="#cb16-94"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-95"><a href="#cb16-95"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-96"><a href="#cb16-96"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-97"><a href="#cb16-97"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-98"><a href="#cb16-98"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-99"><a href="#cb16-99"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-100"><a href="#cb16-100"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-101"><a href="#cb16-101"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-102"><a href="#cb16-102"></a>    )</span>
+<span id="cb16-103"><a href="#cb16-103"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-104"><a href="#cb16-104"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-105"><a href="#cb16-105"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb16-106"><a href="#cb16-106"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-107"><a href="#cb16-107"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-108"><a href="#cb16-108"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-109"><a href="#cb16-109"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-110"><a href="#cb16-110"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb16-111"><a href="#cb16-111"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-112"><a href="#cb16-112"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-113"><a href="#cb16-113"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-114"><a href="#cb16-114"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-115"><a href="#cb16-115"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-116"><a href="#cb16-116"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-117"><a href="#cb16-117"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-118"><a href="#cb16-118"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-119"><a href="#cb16-119"></a>    )</span>
+<span id="cb16-120"><a href="#cb16-120"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-121"><a href="#cb16-121"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-122"><a href="#cb16-122"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-123"><a href="#cb16-123"></a></span>
+<span id="cb16-124"><a href="#cb16-124"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-125"><a href="#cb16-125"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-126"><a href="#cb16-126"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb16-127"><a href="#cb16-127"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-128"><a href="#cb16-128"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-129"><a href="#cb16-129"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-130"><a href="#cb16-130"></a>  )</span>
+<span id="cb16-131"><a href="#cb16-131"></a></span>
+<span id="cb16-132"><a href="#cb16-132"></a>result</span>
+<span id="cb16-133"><a href="#cb16-133"></a><span class="in">```</span></span>
+<span id="cb16-134"><a href="#cb16-134"></a></span>
+<span id="cb16-135"><a href="#cb16-135"></a><span class="fu">## Table with Classes &lt;br/&gt; Sorted by Frequency</span></span>
+<span id="cb16-136"><a href="#cb16-136"></a></span>
+<span id="cb16-137"><a href="#cb16-137"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-138"><a href="#cb16-138"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-139"><a href="#cb16-139"></a></span>
+<span id="cb16-140"><a href="#cb16-140"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-141"><a href="#cb16-141"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-142"><a href="#cb16-142"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-143"><a href="#cb16-143"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-144"><a href="#cb16-144"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-145"><a href="#cb16-145"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-146"><a href="#cb16-146"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-147"><a href="#cb16-147"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-148"><a href="#cb16-148"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-149"><a href="#cb16-149"></a>    )</span>
+<span id="cb16-150"><a href="#cb16-150"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-152"><a href="#cb16-152"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb16-153"><a href="#cb16-153"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-154"><a href="#cb16-154"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-155"><a href="#cb16-155"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-156"><a href="#cb16-156"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-157"><a href="#cb16-157"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb16-158"><a href="#cb16-158"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-159"><a href="#cb16-159"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-160"><a href="#cb16-160"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-161"><a href="#cb16-161"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-162"><a href="#cb16-162"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-163"><a href="#cb16-163"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-164"><a href="#cb16-164"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-165"><a href="#cb16-165"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a>    )</span>
+<span id="cb16-167"><a href="#cb16-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-168"><a href="#cb16-168"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-169"><a href="#cb16-169"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-170"><a href="#cb16-170"></a></span>
+<span id="cb16-171"><a href="#cb16-171"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-172"><a href="#cb16-172"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-173"><a href="#cb16-173"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>), <span class="at">scorefun =</span> cont_n_allcols) <span class="sc">%&gt;%</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>), <span class="at">scorefun =</span> score_occurrences)</span>
+<span id="cb16-175"><a href="#cb16-175"></a></span>
+<span id="cb16-176"><a href="#cb16-176"></a>result</span>
+<span id="cb16-177"><a href="#cb16-177"></a><span class="in">```</span></span>
+<span id="cb16-178"><a href="#cb16-178"></a></span>
+<span id="cb16-179"><a href="#cb16-179"></a><span class="fu">## Table with Total Number of Treatments &lt;br/&gt; per Medication Class Suppressed</span></span>
+<span id="cb16-180"><a href="#cb16-180"></a></span>
+<span id="cb16-181"><a href="#cb16-181"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-182"><a href="#cb16-182"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-183"><a href="#cb16-183"></a></span>
+<span id="cb16-184"><a href="#cb16-184"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-185"><a href="#cb16-185"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-186"><a href="#cb16-186"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-187"><a href="#cb16-187"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-188"><a href="#cb16-188"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-189"><a href="#cb16-189"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-190"><a href="#cb16-190"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-191"><a href="#cb16-191"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb16-192"><a href="#cb16-192"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb16-193"><a href="#cb16-193"></a>    )</span>
+<span id="cb16-194"><a href="#cb16-194"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-195"><a href="#cb16-195"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-196"><a href="#cb16-196"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb16-197"><a href="#cb16-197"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-198"><a href="#cb16-198"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-199"><a href="#cb16-199"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-200"><a href="#cb16-200"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-201"><a href="#cb16-201"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb16-202"><a href="#cb16-202"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-203"><a href="#cb16-203"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-204"><a href="#cb16-204"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-205"><a href="#cb16-205"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb16-206"><a href="#cb16-206"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb16-207"><a href="#cb16-207"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-208"><a href="#cb16-208"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span></span>
+<span id="cb16-209"><a href="#cb16-209"></a>    )</span>
+<span id="cb16-210"><a href="#cb16-210"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-211"><a href="#cb16-211"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-212"><a href="#cb16-212"></a>  <span class="fu">append_varlabels</span>(adcm, <span class="st">"CMDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-213"><a href="#cb16-213"></a></span>
+<span id="cb16-214"><a href="#cb16-214"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-215"><a href="#cb16-215"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-216"><a href="#cb16-216"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb16-217"><a href="#cb16-217"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb16-218"><a href="#cb16-218"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb16-219"><a href="#cb16-219"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb16-220"><a href="#cb16-220"></a>  )</span>
+<span id="cb16-221"><a href="#cb16-221"></a></span>
+<span id="cb16-222"><a href="#cb16-222"></a>result</span>
+<span id="cb16-223"><a href="#cb16-223"></a><span class="in">```</span></span>
+<span id="cb16-224"><a href="#cb16-224"></a></span>
+<span id="cb16-225"><a href="#cb16-225"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-226"><a href="#cb16-226"></a></span>
+<span id="cb16-227"><a href="#cb16-227"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-228"><a href="#cb16-228"></a></span>
+<span id="cb16-229"><a href="#cb16-229"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-230"><a href="#cb16-230"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb16-231"><a href="#cb16-231"></a></span>
+<span id="cb16-232"><a href="#cb16-232"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-233"><a href="#cb16-233"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-234"><a href="#cb16-234"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-235"><a href="#cb16-235"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-236"><a href="#cb16-236"></a></span>
+<span id="cb16-237"><a href="#cb16-237"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-238"><a href="#cb16-238"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb16-239"><a href="#cb16-239"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb16-240"><a href="#cb16-240"></a></span>
+<span id="cb16-241"><a href="#cb16-241"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-242"><a href="#cb16-242"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb16-243"><a href="#cb16-243"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb16-244"><a href="#cb16-244"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb16-245"><a href="#cb16-245"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-246"><a href="#cb16-246"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb16-247"><a href="#cb16-247"></a></span>
+<span id="cb16-248"><a href="#cb16-248"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb16-249"><a href="#cb16-249"></a></span>
+<span id="cb16-250"><a href="#cb16-250"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb16-251"><a href="#cb16-251"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-252"><a href="#cb16-252"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb16-253"><a href="#cb16-253"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb16-254"><a href="#cb16-254"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb16-255"><a href="#cb16-255"></a><span class="st">                  '</span>),</span>
+<span id="cb16-256"><a href="#cb16-256"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb16-257"><a href="#cb16-257"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb16-258"><a href="#cb16-258"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb16-259"><a href="#cb16-259"></a><span class="st">      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb16-260"><a href="#cb16-260"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb16-261"><a href="#cb16-261"></a><span class="st">      '</span>,</span>
+<span id="cb16-262"><a href="#cb16-262"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb16-263"><a href="#cb16-263"></a>    )</span>
+<span id="cb16-264"><a href="#cb16-264"></a>  ),</span>
+<span id="cb16-265"><a href="#cb16-265"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-266"><a href="#cb16-266"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb16-267"><a href="#cb16-267"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb16-268"><a href="#cb16-268"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb16-269"><a href="#cb16-269"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb16-270"><a href="#cb16-270"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb16-271"><a href="#cb16-271"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-272"><a href="#cb16-272"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb16-273"><a href="#cb16-273"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC2"</span>)</span>
+<span id="cb16-274"><a href="#cb16-274"></a>      ),</span>
+<span id="cb16-275"><a href="#cb16-275"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-276"><a href="#cb16-276"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb16-277"><a href="#cb16-277"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb16-278"><a href="#cb16-278"></a>      ),</span>
+<span id="cb16-279"><a href="#cb16-279"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-280"><a href="#cb16-280"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb16-281"><a href="#cb16-281"></a>    )</span>
+<span id="cb16-282"><a href="#cb16-282"></a>  ),</span>
+<span id="cb16-283"><a href="#cb16-283"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb16-284"><a href="#cb16-284"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb16-285"><a href="#cb16-285"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb16-286"><a href="#cb16-286"></a>  )</span>
+<span id="cb16-287"><a href="#cb16-287"></a>)</span>
+<span id="cb16-288"><a href="#cb16-288"></a></span>
+<span id="cb16-289"><a href="#cb16-289"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-290"><a href="#cb16-290"></a><span class="in">```</span></span>
+<span id="cb16-291"><a href="#cb16-291"></a></span>
+<span id="cb16-292"><a href="#cb16-292"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-293"><a href="#cb16-293"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
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+  </div>
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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--- /dev/null
+++ b/stable/tables/concomitant-medications/cmt01b.html
@@ -0,0 +1,2793 @@
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - CMT01B</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
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+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
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+<meta name="quarto:offset" content="../../">
+<link href="../../tables/concomitant-medications/cmt02_pt.html" rel="next">
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+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CMT01B</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Concomitant Medications by Medication Class and Preferred Name</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table with <br> &gt; 1 ATC Class Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Changing <br> Class Levels</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Classes <br> Sorted by Frequency</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Total Number of <br> Treatments per Medication <br> Class Suppressed</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cmt01b_cache/html/setup_60fbf5545d834907fbcf2275fd5c5682">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cmt01b_cache/html/variant1_23f67ab5dd15e4ff1d690b649d82da20">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>    )</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb2-29"><a href="#cb2-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="st">"ATC4"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC4)</span>
+<span id="cb2-45"><a href="#cb2-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">append_topleft</span>(<span class="st">"        Other Treatment"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-48"><a href="#cb2-48"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-49"><a href="#cb2-49"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb2-50"><a href="#cb2-50"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-51"><a href="#cb2-51"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-52"><a href="#cb2-52"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-53"><a href="#cb2-53"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-54"><a href="#cb2-54"></a>    )</span>
+<span id="cb2-55"><a href="#cb2-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-56"><a href="#cb2-56"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L)</span>
+<span id="cb2-57"><a href="#cb2-57"></a></span>
+<span id="cb2-58"><a href="#cb2-58"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-59"><a href="#cb2-59"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-60"><a href="#cb2-60"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb2-61"><a href="#cb2-61"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-62"><a href="#cb2-62"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-63"><a href="#cb2-63"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-64"><a href="#cb2-64"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb2-65"><a href="#cb2-65"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-66"><a href="#cb2-66"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC4"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb2-67"><a href="#cb2-67"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-68"><a href="#cb2-68"></a>  )</span>
+<span id="cb2-69"><a href="#cb2-69"></a></span>
+<span id="cb2-70"><a href="#cb2-70"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 1 Text                                                                                         
+  ATC Level 2 Text                                                                                       
+    ATC Level 3 Text                                                                                     
+      ATC Level 4 Text                                          A: Drug X    B: Placebo    C: Combination
+        Other Treatment                                          (N=134)       (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment           117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                         415           414            460      
+ATCCLAS1 A                                                                                               
+  ATCCLAS2 A                                                                                             
+    ATCCLAS3 A                                                                                           
+      ATCCLAS4 A                                                                                         
+        Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+        Total number of treatments                                 134           137            143      
+        medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+        medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS1 A p2                                                                                            
+  ATCCLAS2 A p2                                                                                          
+    ATCCLAS3 A p2                                                                                        
+      ATCCLAS4 A p2                                                                                      
+        Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+        Total number of treatments                                 58            66              64      
+        medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS1 B                                                                                               
+  ATCCLAS2 B                                                                                             
+    ATCCLAS3 B                                                                                           
+      ATCCLAS4 B                                                                                         
+        Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+        Total number of treatments                                 141           137            162      
+        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+        medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS1 B p2                                                                                            
+  ATCCLAS2 B p2                                                                                          
+    ATCCLAS3 B p2                                                                                        
+      ATCCLAS4 B p2                                                                                      
+        Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+        Total number of treatments                                 75            82              83      
+        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS1 B p3                                                                                            
+  ATCCLAS2 B p3                                                                                          
+    ATCCLAS3 B p3                                                                                        
+      ATCCLAS4 B p3                                                                                      
+        Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+        Total number of treatments                                 75            82              83      
+        medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS1 C                                                                                               
+  ATCCLAS2 C                                                                                             
+    ATCCLAS3 C                                                                                           
+      ATCCLAS4 C                                                                                         
+        Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+        Total number of treatments                                 140           140            155      
+        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+        medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS1 C p2                                                                                            
+  ATCCLAS2 C p2                                                                                          
+    ATCCLAS3 C p2                                                                                        
+      ATCCLAS4 C p2                                                                                      
+        Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+        Total number of treatments                                 140           140            155      
+        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+        medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS1 C p3                                                                                            
+  ATCCLAS2 C p3                                                                                          
+    ATCCLAS3 C p3                                                                                        
+      ATCCLAS4 C p3                                                                                      
+        Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+        Total number of treatments                                 69            73              80      
+        medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="cmt01b_cache/html/variant2_e060c2522b78675d290d36fb8a7c2862">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>    )</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>    )</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-40"><a href="#cb4-40"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Other Treatment"</span>)</span>
+<span id="cb4-41"><a href="#cb4-41"></a></span>
+<span id="cb4-42"><a href="#cb4-42"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-46"><a href="#cb4-46"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb4-49"><a href="#cb4-49"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb4-50"><a href="#cb4-50"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb4-51"><a href="#cb4-51"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb4-52"><a href="#cb4-52"></a>  )</span>
+<span id="cb4-53"><a href="#cb4-53"></a></span>
+<span id="cb4-54"><a href="#cb4-54"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 3 Text                                                                                     
+  ATC Level 2 Text                                          A: Drug X    B: Placebo    C: Combination
+    Other Treatment                                          (N=134)       (N=134)        (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment       117 (87.3%)   116 (86.6%)    116 (87.9%)  
+Total number of treatments                                     415           414            460      
+ATCCLAS3 A                                                                                           
+  ATCCLAS2 A                                                                                         
+    Total number of patients with at least one treatment   75 (56.0%)    79 (59.0%)      81 (61.4%)  
+    Total number of treatments                                 134           137            143      
+    medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)  
+    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS3 A p2                                                                                        
+  ATCCLAS2 A p2                                                                                      
+    Total number of patients with at least one treatment   45 (33.6%)    54 (40.3%)      48 (36.4%)  
+    Total number of treatments                                 58            66              64      
+    medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)  
+ATCCLAS3 B                                                                                           
+  ATCCLAS2 B                                                                                         
+    Total number of patients with at least one treatment   83 (61.9%)    74 (55.2%)      88 (66.7%)  
+    Total number of treatments                                 141           137            162      
+    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+    medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)  
+ATCCLAS3 B p2                                                                                        
+  ATCCLAS2 B p2                                                                                      
+    Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+    Total number of treatments                                 75            82              83      
+    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS3 B p3                                                                                        
+  ATCCLAS2 B p3                                                                                      
+    Total number of patients with at least one treatment   52 (38.8%)    57 (42.5%)      59 (44.7%)  
+    Total number of treatments                                 75            82              83      
+    medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)  
+ATCCLAS3 C                                                                                           
+  ATCCLAS2 C                                                                                         
+    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+    Total number of treatments                                 140           140            155      
+    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS3 C p2                                                                                        
+  ATCCLAS2 C p2                                                                                      
+    Total number of patients with at least one treatment   82 (61.2%)    84 (62.7%)      89 (67.4%)  
+    Total number of treatments                                 140           140            155      
+    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  
+    medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)  
+ATCCLAS3 C p3                                                                                        
+  ATCCLAS2 C p3                                                                                      
+    Total number of patients with at least one treatment   52 (38.8%)    58 (43.3%)      60 (45.5%)  
+    Total number of treatments                                 69            73              80      
+    medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-hash="cmt01b_cache/html/variant3_c4c428e2f92c0db05a1b70133bbbd300">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="cmt01b_cache/html/variant4_1462fe072462d39f03fb8e3069ec37c2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-5"><a href="#cb7-5"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-6"><a href="#cb7-6"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb7-7"><a href="#cb7-7"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-8"><a href="#cb7-8"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb7-9"><a href="#cb7-9"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-10"><a href="#cb7-10"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-11"><a href="#cb7-11"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb7-12"><a href="#cb7-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-13"><a href="#cb7-13"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb7-15"><a href="#cb7-15"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-16"><a href="#cb7-16"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb7-17"><a href="#cb7-17"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-18"><a href="#cb7-18"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-19"><a href="#cb7-19"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb7-20"><a href="#cb7-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-21"><a href="#cb7-21"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-22"><a href="#cb7-22"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb7-23"><a href="#cb7-23"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-27"><a href="#cb7-27"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb7-28"><a href="#cb7-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-29"><a href="#cb7-29"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb7-30"><a href="#cb7-30"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb7-31"><a href="#cb7-31"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb7-32"><a href="#cb7-32"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb7-33"><a href="#cb7-33"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb7-34"><a href="#cb7-34"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb7-35"><a href="#cb7-35"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb7-36"><a href="#cb7-36"></a>    )</span>
+<span id="cb7-37"><a href="#cb7-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-38"><a href="#cb7-38"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-39"><a href="#cb7-39"></a>    <span class="st">"ATC4"</span>,</span>
+<span id="cb7-40"><a href="#cb7-40"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-41"><a href="#cb7-41"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb7-42"><a href="#cb7-42"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb7-43"><a href="#cb7-43"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb7-44"><a href="#cb7-44"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-45"><a href="#cb7-45"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC4)</span>
+<span id="cb7-46"><a href="#cb7-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-47"><a href="#cb7-47"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb7-48"><a href="#cb7-48"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb7-49"><a href="#cb7-49"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb7-50"><a href="#cb7-50"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb7-51"><a href="#cb7-51"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span></span>
+<span id="cb7-52"><a href="#cb7-52"></a>    )</span>
+<span id="cb7-53"><a href="#cb7-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-54"><a href="#cb7-54"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb7-55"><a href="#cb7-55"></a>  <span class="fu">append_topleft</span>(<span class="st">"        Other Treatment"</span>)</span>
+<span id="cb7-56"><a href="#cb7-56"></a></span>
+<span id="cb7-57"><a href="#cb7-57"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb7-58"><a href="#cb7-58"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb7-59"><a href="#cb7-59"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb7-60"><a href="#cb7-60"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb7-61"><a href="#cb7-61"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-62"><a href="#cb7-62"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb7-63"><a href="#cb7-63"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb7-64"><a href="#cb7-64"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb7-65"><a href="#cb7-65"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC4"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb7-66"><a href="#cb7-66"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb7-67"><a href="#cb7-67"></a>  )</span>
+<span id="cb7-68"><a href="#cb7-68"></a></span>
+<span id="cb7-69"><a href="#cb7-69"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>ATC Level 1 Text                                                                                       
+  ATC Level 2 Text                                                                                     
+    ATC Level 3 Text                                                                                   
+      ATC Level 4 Text                                         A: Drug X    B: Placebo   C: Combination
+        Other Treatment                                         (N=134)      (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————————
+ATCCLAS1 A                                                                                             
+  ATCCLAS2 A                                                                                           
+    ATCCLAS3 A                                                                                         
+      Total number of patients with at least one treatment     75 (56.0%)   79 (59.0%)     81 (61.4%)  
+      Total number of treatments                                  134          137            143      
+      ATCCLAS4 A                                                                                       
+        Total number of patients with at least one treatment   75 (56.0%)   79 (59.0%)     81 (61.4%)  
+        medname A_2/3                                          53 (39.6%)   50 (37.3%)     56 (42.4%)  
+        medname A_3/3                                          45 (33.6%)   54 (40.3%)     48 (36.4%)  
+ATCCLAS1 A p2                                                                                          
+  ATCCLAS2 A p2                                                                                        
+    ATCCLAS3 A p2                                                                                      
+      Total number of patients with at least one treatment     45 (33.6%)   54 (40.3%)     48 (36.4%)  
+      Total number of treatments                                   58           66             64      
+      ATCCLAS4 A p2                                                                                    
+        Total number of patients with at least one treatment   45 (33.6%)   54 (40.3%)     48 (36.4%)  
+        medname A_3/3                                          45 (33.6%)   54 (40.3%)     48 (36.4%)  
+ATCCLAS1 B                                                                                             
+  ATCCLAS2 B                                                                                           
+    ATCCLAS3 B                                                                                         
+      Total number of patients with at least one treatment     83 (61.9%)   74 (55.2%)     88 (66.7%)  
+      Total number of treatments                                  141          137            162      
+      ATCCLAS4 B                                                                                       
+        Total number of patients with at least one treatment   83 (61.9%)   74 (55.2%)     88 (66.7%)  
+        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  
+        medname B_4/4                                          50 (37.3%)   45 (33.6%)     55 (41.7%)  
+ATCCLAS1 B p2                                                                                          
+  ATCCLAS2 B p2                                                                                        
+    ATCCLAS3 B p2                                                                                      
+      Total number of patients with at least one treatment     52 (38.8%)   57 (42.5%)     59 (44.7%)  
+      Total number of treatments                                   75           82             83      
+      ATCCLAS4 B p2                                                                                    
+        Total number of patients with at least one treatment   52 (38.8%)   57 (42.5%)     59 (44.7%)  
+        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  
+ATCCLAS1 B p3                                                                                          
+  ATCCLAS2 B p3                                                                                        
+    ATCCLAS3 B p3                                                                                      
+      Total number of patients with at least one treatment     52 (38.8%)   57 (42.5%)     59 (44.7%)  
+      Total number of treatments                                   75           82             83      
+      ATCCLAS4 B p3                                                                                    
+        Total number of patients with at least one treatment   52 (38.8%)   57 (42.5%)     59 (44.7%)  
+        medname B_1/4                                          52 (38.8%)   57 (42.5%)     59 (44.7%)  
+ATCCLAS1 C                                                                                             
+  ATCCLAS2 C                                                                                           
+    ATCCLAS3 C                                                                                         
+      Total number of patients with at least one treatment     82 (61.2%)   84 (62.7%)     89 (67.4%)  
+      Total number of treatments                                  140          140            155      
+      ATCCLAS4 C                                                                                       
+        Total number of patients with at least one treatment   82 (61.2%)   84 (62.7%)     89 (67.4%)  
+        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  
+        medname C_1/2                                          51 (38.1%)   50 (37.3%)     56 (42.4%)  
+ATCCLAS1 C p2                                                                                          
+  ATCCLAS2 C p2                                                                                        
+    ATCCLAS3 C p2                                                                                      
+      Total number of patients with at least one treatment     82 (61.2%)   84 (62.7%)     89 (67.4%)  
+      Total number of treatments                                  140          140            155      
+      ATCCLAS4 C p2                                                                                    
+        Total number of patients with at least one treatment   82 (61.2%)   84 (62.7%)     89 (67.4%)  
+        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  
+        medname C_1/2                                          51 (38.1%)   50 (37.3%)     56 (42.4%)  
+ATCCLAS1 C p3                                                                                          
+  ATCCLAS2 C p3                                                                                        
+    ATCCLAS3 C p3                                                                                      
+      Total number of patients with at least one treatment     52 (38.8%)   58 (43.3%)     60 (45.5%)  
+      Total number of treatments                                   69           73             80      
+      ATCCLAS4 C p3                                                                                    
+        Total number of patients with at least one treatment   52 (38.8%)   58 (43.3%)     60 (45.5%)  
+        medname C_2/2                                          52 (38.8%)   58 (43.3%)     60 (45.5%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="cmt01b_cache/html/teal_02be58ceae221f4375856d329d439629">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb9-7"><a href="#cb9-7"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb9-8"><a href="#cb9-8"></a></span>
+<span id="cb9-9"><a href="#cb9-9"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb9-10"><a href="#cb9-10"></a></span>
+<span id="cb9-11"><a href="#cb9-11"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb9-12"><a href="#cb9-12"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb9-15"><a href="#cb9-15"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb9-16"><a href="#cb9-16"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb9-17"><a href="#cb9-17"></a></span>
+<span id="cb9-18"><a href="#cb9-18"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb9-19"><a href="#cb9-19"></a></span>
+<span id="cb9-20"><a href="#cb9-20"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb9-21"><a href="#cb9-21"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb9-22"><a href="#cb9-22"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb9-23"><a href="#cb9-23"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb9-24"><a href="#cb9-24"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb9-25"><a href="#cb9-25"></a><span class="st">                  '</span>),</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb9-27"><a href="#cb9-27"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb9-28"><a href="#cb9-28"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a><span class="st">      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb9-31"><a href="#cb9-31"></a><span class="st">      '</span>,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    )</span>
+<span id="cb9-34"><a href="#cb9-34"></a>  ),</span>
+<span id="cb9-35"><a href="#cb9-35"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb9-36"><a href="#cb9-36"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb9-37"><a href="#cb9-37"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb9-39"><a href="#cb9-39"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb9-40"><a href="#cb9-40"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb9-41"><a href="#cb9-41"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-42"><a href="#cb9-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb9-43"><a href="#cb9-43"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb9-44"><a href="#cb9-44"></a>      ),</span>
+<span id="cb9-45"><a href="#cb9-45"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb9-46"><a href="#cb9-46"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb9-47"><a href="#cb9-47"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb9-48"><a href="#cb9-48"></a>      ),</span>
+<span id="cb9-49"><a href="#cb9-49"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb9-50"><a href="#cb9-50"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb9-51"><a href="#cb9-51"></a>    )</span>
+<span id="cb9-52"><a href="#cb9-52"></a>  ),</span>
+<span id="cb9-53"><a href="#cb9-53"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb9-54"><a href="#cb9-54"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb9-55"><a href="#cb9-55"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb9-56"><a href="#cb9-56"></a>  )</span>
+<span id="cb9-57"><a href="#cb9-57"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:09:09.3393 pid:8918 token:[] teal.modules.clinical Initializing tm_t_mult_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cmt01b_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cmt01b_cache/html/sessioninfo_c5ec18a9d94ec871275a263734dd3cb0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cmt01b_cache/html/snapshot_22afb7a5b4eccedcd3cc4e0d20f8775e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/concomitant-medications/cmt01b.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+      <a href="../../tables/concomitant-medications/cmt01a.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CMT01A</span>
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> CMT01B</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Concomitant Medications by Medication Class and Preferred Name</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>::: panel-tabset</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-14"><a href="#cb15-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a></span>
+<span id="cb15-16"><a href="#cb15-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-17"><a href="#cb15-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb15-18"><a href="#cb15-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-19"><a href="#cb15-19"></a></span>
+<span id="cb15-20"><a href="#cb15-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-21"><a href="#cb15-21"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb15-22"><a href="#cb15-22"></a></span>
+<span id="cb15-23"><a href="#cb15-23"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb15-24"><a href="#cb15-24"></a></span>
+<span id="cb15-25"><a href="#cb15-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb15-26"><a href="#cb15-26"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb15-27"><a href="#cb15-27"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb15-28"><a href="#cb15-28"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb15-29"><a href="#cb15-29"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb15-30"><a href="#cb15-30"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb15-31"><a href="#cb15-31"></a></span>
+<span id="cb15-32"><a href="#cb15-32"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb15-33"><a href="#cb15-33"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb15-34"><a href="#cb15-34"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb15-35"><a href="#cb15-35"></a></span>
+<span id="cb15-36"><a href="#cb15-36"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span></span>
+<span id="cb15-37"><a href="#cb15-37"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb15-38"><a href="#cb15-38"></a><span class="in">```</span></span>
+<span id="cb15-39"><a href="#cb15-39"></a></span>
+<span id="cb15-40"><a href="#cb15-40"></a><span class="fu">## Standard Table with &lt;br/&gt; \&gt; 1 ATC Class Level</span></span>
+<span id="cb15-41"><a href="#cb15-41"></a></span>
+<span id="cb15-42"><a href="#cb15-42"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb15-44"><a href="#cb15-44"></a></span>
+<span id="cb15-45"><a href="#cb15-45"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-46"><a href="#cb15-46"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-47"><a href="#cb15-47"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb15-48"><a href="#cb15-48"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-49"><a href="#cb15-49"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb15-50"><a href="#cb15-50"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb15-51"><a href="#cb15-51"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-52"><a href="#cb15-52"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb15-53"><a href="#cb15-53"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb15-54"><a href="#cb15-54"></a>    )</span>
+<span id="cb15-55"><a href="#cb15-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-56"><a href="#cb15-56"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-57"><a href="#cb15-57"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb15-58"><a href="#cb15-58"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-59"><a href="#cb15-59"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb15-60"><a href="#cb15-60"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-61"><a href="#cb15-61"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-62"><a href="#cb15-62"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb15-63"><a href="#cb15-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-64"><a href="#cb15-64"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-65"><a href="#cb15-65"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb15-66"><a href="#cb15-66"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-67"><a href="#cb15-67"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-68"><a href="#cb15-68"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-69"><a href="#cb15-69"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-70"><a href="#cb15-70"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb15-71"><a href="#cb15-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-72"><a href="#cb15-72"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-73"><a href="#cb15-73"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb15-74"><a href="#cb15-74"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-75"><a href="#cb15-75"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-76"><a href="#cb15-76"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-77"><a href="#cb15-77"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-78"><a href="#cb15-78"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb15-79"><a href="#cb15-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-80"><a href="#cb15-80"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-81"><a href="#cb15-81"></a>    <span class="st">"ATC4"</span>,</span>
+<span id="cb15-82"><a href="#cb15-82"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-83"><a href="#cb15-83"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-84"><a href="#cb15-84"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-85"><a href="#cb15-85"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-86"><a href="#cb15-86"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC4)</span>
+<span id="cb15-87"><a href="#cb15-87"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-88"><a href="#cb15-88"></a>  <span class="fu">append_topleft</span>(<span class="st">"        Other Treatment"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-89"><a href="#cb15-89"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-90"><a href="#cb15-90"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-91"><a href="#cb15-91"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb15-92"><a href="#cb15-92"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb15-93"><a href="#cb15-93"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-94"><a href="#cb15-94"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb15-95"><a href="#cb15-95"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb15-96"><a href="#cb15-96"></a>    )</span>
+<span id="cb15-97"><a href="#cb15-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-98"><a href="#cb15-98"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L)</span>
+<span id="cb15-99"><a href="#cb15-99"></a></span>
+<span id="cb15-100"><a href="#cb15-100"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb15-101"><a href="#cb15-101"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb15-102"><a href="#cb15-102"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb15-103"><a href="#cb15-103"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb15-104"><a href="#cb15-104"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-105"><a href="#cb15-105"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-106"><a href="#cb15-106"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb15-107"><a href="#cb15-107"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-108"><a href="#cb15-108"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC4"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb15-109"><a href="#cb15-109"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb15-110"><a href="#cb15-110"></a>  )</span>
+<span id="cb15-111"><a href="#cb15-111"></a></span>
+<span id="cb15-112"><a href="#cb15-112"></a>result</span>
+<span id="cb15-113"><a href="#cb15-113"></a><span class="in">```</span></span>
+<span id="cb15-114"><a href="#cb15-114"></a></span>
+<span id="cb15-115"><a href="#cb15-115"></a><span class="fu">## Table Changing &lt;br/&gt; Class Levels</span></span>
+<span id="cb15-116"><a href="#cb15-116"></a></span>
+<span id="cb15-117"><a href="#cb15-117"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb15-118"><a href="#cb15-118"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb15-119"><a href="#cb15-119"></a></span>
+<span id="cb15-120"><a href="#cb15-120"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-121"><a href="#cb15-121"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-122"><a href="#cb15-122"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb15-123"><a href="#cb15-123"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-124"><a href="#cb15-124"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb15-125"><a href="#cb15-125"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb15-126"><a href="#cb15-126"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-127"><a href="#cb15-127"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb15-128"><a href="#cb15-128"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb15-129"><a href="#cb15-129"></a>    )</span>
+<span id="cb15-130"><a href="#cb15-130"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-131"><a href="#cb15-131"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-132"><a href="#cb15-132"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb15-133"><a href="#cb15-133"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-134"><a href="#cb15-134"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb15-135"><a href="#cb15-135"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-136"><a href="#cb15-136"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-137"><a href="#cb15-137"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb15-138"><a href="#cb15-138"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-139"><a href="#cb15-139"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-140"><a href="#cb15-140"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb15-141"><a href="#cb15-141"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-142"><a href="#cb15-142"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-143"><a href="#cb15-143"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-144"><a href="#cb15-144"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-145"><a href="#cb15-145"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb15-146"><a href="#cb15-146"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-147"><a href="#cb15-147"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-148"><a href="#cb15-148"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-149"><a href="#cb15-149"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb15-150"><a href="#cb15-150"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb15-151"><a href="#cb15-151"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-152"><a href="#cb15-152"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb15-153"><a href="#cb15-153"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb15-154"><a href="#cb15-154"></a>    )</span>
+<span id="cb15-155"><a href="#cb15-155"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-156"><a href="#cb15-156"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Other Treatment"</span>)</span>
+<span id="cb15-158"><a href="#cb15-158"></a></span>
+<span id="cb15-159"><a href="#cb15-159"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb15-160"><a href="#cb15-160"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb15-161"><a href="#cb15-161"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb15-162"><a href="#cb15-162"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb15-163"><a href="#cb15-163"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-164"><a href="#cb15-164"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-165"><a href="#cb15-165"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb15-166"><a href="#cb15-166"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-167"><a href="#cb15-167"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb15-168"><a href="#cb15-168"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb15-169"><a href="#cb15-169"></a>  )</span>
+<span id="cb15-170"><a href="#cb15-170"></a></span>
+<span id="cb15-171"><a href="#cb15-171"></a>result</span>
+<span id="cb15-172"><a href="#cb15-172"></a><span class="in">```</span></span>
+<span id="cb15-173"><a href="#cb15-173"></a></span>
+<span id="cb15-174"><a href="#cb15-174"></a><span class="fu">## Table with Classes &lt;br/&gt; Sorted by Frequency</span></span>
+<span id="cb15-175"><a href="#cb15-175"></a></span>
+<span id="cb15-176"><a href="#cb15-176"></a><span class="in">```{r variant3}</span></span>
+<span id="cb15-177"><a href="#cb15-177"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-178"><a href="#cb15-178"></a></span>
+<span id="cb15-179"><a href="#cb15-179"></a><span class="co"># In progress</span></span>
+<span id="cb15-180"><a href="#cb15-180"></a><span class="in">```</span></span>
+<span id="cb15-181"><a href="#cb15-181"></a></span>
+<span id="cb15-182"><a href="#cb15-182"></a><span class="fu">## Table with Total Number of &lt;br/&gt; Treatments per Medication &lt;br/&gt; Class Suppressed</span></span>
+<span id="cb15-183"><a href="#cb15-183"></a></span>
+<span id="cb15-184"><a href="#cb15-184"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb15-185"><a href="#cb15-185"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb15-186"><a href="#cb15-186"></a></span>
+<span id="cb15-187"><a href="#cb15-187"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-188"><a href="#cb15-188"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-189"><a href="#cb15-189"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-190"><a href="#cb15-190"></a>    <span class="st">"ATC1"</span>,</span>
+<span id="cb15-191"><a href="#cb15-191"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-192"><a href="#cb15-192"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb15-193"><a href="#cb15-193"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-194"><a href="#cb15-194"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-195"><a href="#cb15-195"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC1)</span>
+<span id="cb15-196"><a href="#cb15-196"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-197"><a href="#cb15-197"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-198"><a href="#cb15-198"></a>    <span class="st">"ATC2"</span>,</span>
+<span id="cb15-199"><a href="#cb15-199"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-200"><a href="#cb15-200"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-201"><a href="#cb15-201"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-202"><a href="#cb15-202"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-203"><a href="#cb15-203"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC2)</span>
+<span id="cb15-204"><a href="#cb15-204"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-205"><a href="#cb15-205"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-206"><a href="#cb15-206"></a>    <span class="st">"ATC3"</span>,</span>
+<span id="cb15-207"><a href="#cb15-207"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-208"><a href="#cb15-208"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-209"><a href="#cb15-209"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-210"><a href="#cb15-210"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-211"><a href="#cb15-211"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC3)</span>
+<span id="cb15-212"><a href="#cb15-212"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-213"><a href="#cb15-213"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-214"><a href="#cb15-214"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-215"><a href="#cb15-215"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb15-216"><a href="#cb15-216"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb15-217"><a href="#cb15-217"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-218"><a href="#cb15-218"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb15-219"><a href="#cb15-219"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb15-220"><a href="#cb15-220"></a>    )</span>
+<span id="cb15-221"><a href="#cb15-221"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-222"><a href="#cb15-222"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb15-223"><a href="#cb15-223"></a>    <span class="st">"ATC4"</span>,</span>
+<span id="cb15-224"><a href="#cb15-224"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb15-225"><a href="#cb15-225"></a>    <span class="at">nested =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb15-226"><a href="#cb15-226"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb15-227"><a href="#cb15-227"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb15-228"><a href="#cb15-228"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb15-229"><a href="#cb15-229"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adcm<span class="sc">$</span>ATC4)</span>
+<span id="cb15-230"><a href="#cb15-230"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-231"><a href="#cb15-231"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb15-232"><a href="#cb15-232"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-233"><a href="#cb15-233"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb15-234"><a href="#cb15-234"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-235"><a href="#cb15-235"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span></span>
+<span id="cb15-236"><a href="#cb15-236"></a>    )</span>
+<span id="cb15-237"><a href="#cb15-237"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-238"><a href="#cb15-238"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb15-239"><a href="#cb15-239"></a>  <span class="fu">append_topleft</span>(<span class="st">"        Other Treatment"</span>)</span>
+<span id="cb15-240"><a href="#cb15-240"></a></span>
+<span id="cb15-241"><a href="#cb15-241"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb15-242"><a href="#cb15-242"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb15-243"><a href="#cb15-243"></a>  <span class="at">df =</span> adcm,</span>
+<span id="cb15-244"><a href="#cb15-244"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb15-245"><a href="#cb15-245"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-246"><a href="#cb15-246"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-247"><a href="#cb15-247"></a>  <span class="co"># Sort lowest level terms by descending frequency.</span></span>
+<span id="cb15-248"><a href="#cb15-248"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb15-249"><a href="#cb15-249"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"*"</span>, <span class="st">"ATC2"</span>, <span class="st">"*"</span>, <span class="st">"ATC3"</span>, <span class="st">"*"</span>, <span class="st">"ATC4"</span>, <span class="st">"*"</span>, <span class="st">"CMDECOD"</span>),</span>
+<span id="cb15-250"><a href="#cb15-250"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb15-251"><a href="#cb15-251"></a>  )</span>
+<span id="cb15-252"><a href="#cb15-252"></a></span>
+<span id="cb15-253"><a href="#cb15-253"></a>result</span>
+<span id="cb15-254"><a href="#cb15-254"></a><span class="in">```</span></span>
+<span id="cb15-255"><a href="#cb15-255"></a></span>
+<span id="cb15-256"><a href="#cb15-256"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-257"><a href="#cb15-257"></a></span>
+<span id="cb15-258"><a href="#cb15-258"></a><span class="fu">## `teal` App</span></span>
+<span id="cb15-259"><a href="#cb15-259"></a></span>
+<span id="cb15-260"><a href="#cb15-260"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb15-261"><a href="#cb15-261"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb15-262"><a href="#cb15-262"></a></span>
+<span id="cb15-263"><a href="#cb15-263"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-264"><a href="#cb15-264"></a><span class="fu">library</span>(tern)</span>
+<span id="cb15-265"><a href="#cb15-265"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-266"><a href="#cb15-266"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb15-267"><a href="#cb15-267"></a></span>
+<span id="cb15-268"><a href="#cb15-268"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-269"><a href="#cb15-269"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb15-270"><a href="#cb15-270"></a></span>
+<span id="cb15-271"><a href="#cb15-271"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb15-272"><a href="#cb15-272"></a></span>
+<span id="cb15-273"><a href="#cb15-273"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb15-274"><a href="#cb15-274"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb15-275"><a href="#cb15-275"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb15-276"><a href="#cb15-276"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb15-277"><a href="#cb15-277"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb15-278"><a href="#cb15-278"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb15-279"><a href="#cb15-279"></a></span>
+<span id="cb15-280"><a href="#cb15-280"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb15-281"><a href="#cb15-281"></a></span>
+<span id="cb15-282"><a href="#cb15-282"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb15-283"><a href="#cb15-283"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb15-284"><a href="#cb15-284"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb15-285"><a href="#cb15-285"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb15-286"><a href="#cb15-286"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb15-287"><a href="#cb15-287"></a><span class="st">                  '</span>),</span>
+<span id="cb15-288"><a href="#cb15-288"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb15-289"><a href="#cb15-289"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb15-290"><a href="#cb15-290"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb15-291"><a href="#cb15-291"></a><span class="st">      ADCM$CMSEQ &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb15-292"><a href="#cb15-292"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb15-293"><a href="#cb15-293"></a><span class="st">      '</span>,</span>
+<span id="cb15-294"><a href="#cb15-294"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb15-295"><a href="#cb15-295"></a>    )</span>
+<span id="cb15-296"><a href="#cb15-296"></a>  ),</span>
+<span id="cb15-297"><a href="#cb15-297"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb15-298"><a href="#cb15-298"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb15-299"><a href="#cb15-299"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb15-300"><a href="#cb15-300"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb15-301"><a href="#cb15-301"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb15-302"><a href="#cb15-302"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb15-303"><a href="#cb15-303"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-304"><a href="#cb15-304"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb15-305"><a href="#cb15-305"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb15-306"><a href="#cb15-306"></a>      ),</span>
+<span id="cb15-307"><a href="#cb15-307"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-308"><a href="#cb15-308"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb15-309"><a href="#cb15-309"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb15-310"><a href="#cb15-310"></a>      ),</span>
+<span id="cb15-311"><a href="#cb15-311"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb15-312"><a href="#cb15-312"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb15-313"><a href="#cb15-313"></a>    )</span>
+<span id="cb15-314"><a href="#cb15-314"></a>  ),</span>
+<span id="cb15-315"><a href="#cb15-315"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb15-316"><a href="#cb15-316"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb15-317"><a href="#cb15-317"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb15-318"><a href="#cb15-318"></a>  )</span>
+<span id="cb15-319"><a href="#cb15-319"></a>)</span>
+<span id="cb15-320"><a href="#cb15-320"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb15-321"><a href="#cb15-321"></a><span class="in">```</span></span>
+<span id="cb15-322"><a href="#cb15-322"></a></span>
+<span id="cb15-323"><a href="#cb15-323"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-324"><a href="#cb15-324"></a></span>
+<span id="cb15-325"><a href="#cb15-325"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
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+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/concomitant-medications/cmt02_pt.html
@@ -0,0 +1,2233 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - CMT02_PT</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
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+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+div.sourceCode { margin: 1em 0; }
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+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+    -khtml-user-select: none; -moz-user-select: none;
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+div.sourceCode
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+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CMT02_PT</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Concomitant Medications by Preferred Name (WHODrug Coding)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cmt02_pt_cache/html/setup_0d097091d53378fb114c8b3c7135bcc5">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl, <span class="at">na_level =</span> <span class="st">"No Coding Available"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm, <span class="at">na_level =</span> <span class="st">"No Coding Available"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a><span class="co"># Keep only concomitant medications</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cmt02_pt_cache/html/variant1_e46d4a858ad7f0080ae03455b2af1203">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>    ),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">append_topleft</span>(<span class="fu">paste</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Other Treatment"</span>))</span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  )</span>
+<span id="cb2-24"><a href="#cb2-24"></a></span>
+<span id="cb2-25"><a href="#cb2-25"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                        A: Drug X    B: Placebo    C: Combination   All Patients
+Other Treatment                                          (N=134)       (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one treatment   117 (87.3%)   116 (86.6%)    116 (87.9%)     349 (87.2%) 
+Total number of treatments                                 415           414            460             1289    
+medname C_2/2                                          52 (38.8%)    58 (43.3%)      60 (45.5%)     170 (42.5%) 
+medname B_1/4                                          52 (38.8%)    57 (42.5%)      59 (44.7%)     168 (42.0%) 
+medname A_2/3                                          53 (39.6%)    50 (37.3%)      56 (42.4%)     159 (39.8%) 
+medname C_1/2                                          51 (38.1%)    50 (37.3%)      56 (42.4%)     157 (39.2%) 
+medname B_4/4                                          50 (37.3%)    45 (33.6%)      55 (41.7%)     150 (37.5%) 
+medname A_3/3                                          45 (33.6%)    54 (40.3%)      48 (36.4%)     147 (36.8%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:24}" data-hash="cmt02_pt_cache/html/teal_5e27062d4ab2621d4855f0248a4c00cf">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-16"><a href="#cb4-16"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb4-17"><a href="#cb4-17"></a></span>
+<span id="cb4-18"><a href="#cb4-18"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb4-19"><a href="#cb4-19"></a></span>
+<span id="cb4-20"><a href="#cb4-20"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a><span class="st">                  '</span>),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a><span class="st">      ADCM$CMID &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a><span class="st">      '</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    )</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  ),</span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb4-37"><a href="#cb4-37"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb4-38"><a href="#cb4-38"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-41"><a href="#cb4-41"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>)</span>
+<span id="cb4-44"><a href="#cb4-44"></a>      ),</span>
+<span id="cb4-45"><a href="#cb4-45"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-46"><a href="#cb4-46"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb4-47"><a href="#cb4-47"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb4-48"><a href="#cb4-48"></a>      ),</span>
+<span id="cb4-49"><a href="#cb4-49"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-50"><a href="#cb4-50"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>    )</span>
+<span id="cb4-52"><a href="#cb4-52"></a>  ),</span>
+<span id="cb4-53"><a href="#cb4-53"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb4-54"><a href="#cb4-54"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb4-55"><a href="#cb4-55"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb4-56"><a href="#cb4-56"></a>  )</span>
+<span id="cb4-57"><a href="#cb4-57"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:08:20.5132 pid:8820 token:[] teal.modules.clinical Initializing tm_t_mult_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cmt02_pt_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cmt02_pt_cache/html/sessioninfo_29e6031bc2a0250c6f6cb06fafa5ff00">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cmt02_pt_cache/html/snapshot_eb8b116fe1e2ab202f82cc3aaf302f95">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> CMT02_PT</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Concomitant Medications by Preferred Name (WHODrug Coding)</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl, <span class="at">na_level =</span> <span class="st">"No Coding Available"</span>)</span>
+<span id="cb10-28"><a href="#cb10-28"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm, <span class="at">na_level =</span> <span class="st">"No Coding Available"</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="co"># Keep only safety-evaluable patients and concomitant medications</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-33"><a href="#cb10-33"></a></span>
+<span id="cb10-34"><a href="#cb10-34"></a><span class="co"># Keep only concomitant medications</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a>adcm <span class="ot">&lt;-</span> adcm <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ATIREL <span class="sc">==</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="in">```</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-42"><a href="#cb10-42"></a></span>
+<span id="cb10-43"><a href="#cb10-43"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    <span class="at">count_by =</span> <span class="st">"CMSEQ"</span>,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-51"><a href="#cb10-51"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one treatment"</span>,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of treatments"</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>    ),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"CMDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="fu">append_topleft</span>(<span class="fu">paste</span>(<span class="st">"</span><span class="sc">\n</span><span class="st">Other Treatment"</span>))</span>
+<span id="cb10-58"><a href="#cb10-58"></a></span>
+<span id="cb10-59"><a href="#cb10-59"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adcm, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="fu">sort_at_path</span>(</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">path =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>),</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="at">scorefun =</span> score_occurrences</span>
+<span id="cb10-63"><a href="#cb10-63"></a>  )</span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a>result</span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="in">```</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-69"><a href="#cb10-69"></a></span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a><span class="co">#| screenshot.opts = list(delay = 24)</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-76"><a href="#cb10-76"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-78"><a href="#cb10-78"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-79"><a href="#cb10-79"></a></span>
+<span id="cb10-80"><a href="#cb10-80"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-81"><a href="#cb10-81"></a>adcm <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adcm"</span>)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>adcm<span class="sc">$</span>CMSEQ <span class="ot">&lt;-</span> <span class="fu">as.integer</span>(adcm<span class="sc">$</span>CMSEQ)</span>
+<span id="cb10-84"><a href="#cb10-84"></a></span>
+<span id="cb10-85"><a href="#cb10-85"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a><span class="co"># If you want your missing levels to show as "No Coding Available", please use</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a><span class="co"># adsl &lt;- df_explicit_na(adsl, na_level = "No Coding Available")</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a><span class="co"># adcm &lt;- df_explicit_na(adcm, na_level = "No Coding Available")</span></span>
+<span id="cb10-89"><a href="#cb10-89"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-90"><a href="#cb10-90"></a>adcm <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adcm)</span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a>adcm_keys <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"ASTDTM"</span>, <span class="st">"CMSEQ"</span>, <span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)</span>
+<span id="cb10-93"><a href="#cb10-93"></a></span>
+<span id="cb10-94"><a href="#cb10-94"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb10-95"><a href="#cb10-95"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-96"><a href="#cb10-96"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="st">                  ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="st">                  ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="st">                  '</span>),</span>
+<span id="cb10-100"><a href="#cb10-100"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADCM"</span>, adcm,</span>
+<span id="cb10-101"><a href="#cb10-101"></a>      <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb10-102"><a href="#cb10-102"></a><span class="st">      ADCM &lt;- synthetic_cdisc_dataset("latest", "adcm")</span></span>
+<span id="cb10-103"><a href="#cb10-103"></a><span class="st">      ADCM$CMID &lt;- as.factor(ADCM$CMSEQ)</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="st">      ADCM &lt;- df_explicit_na(ADCM)</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a><span class="st">      '</span>,</span>
+<span id="cb10-106"><a href="#cb10-106"></a>      <span class="at">keys =</span> adcm_keys</span>
+<span id="cb10-107"><a href="#cb10-107"></a>    )</span>
+<span id="cb10-108"><a href="#cb10-108"></a>  ),</span>
+<span id="cb10-109"><a href="#cb10-109"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="fu">tm_t_mult_events</span>(</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      <span class="at">label =</span> <span class="st">"Concomitant Medications by Medication Class and Preferred Name"</span>,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">dataname =</span> <span class="st">"ADCM"</span>,</span>
+<span id="cb10-113"><a href="#cb10-113"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-114"><a href="#cb10-114"></a>      <span class="at">seq_var =</span> <span class="fu">choices_selected</span>(<span class="st">"CMSEQ"</span>, <span class="at">selected =</span> <span class="st">"CMSEQ"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb10-115"><a href="#cb10-115"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-116"><a href="#cb10-116"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"ATC1"</span>, <span class="st">"ATC2"</span>, <span class="st">"ATC3"</span>, <span class="st">"ATC4"</span>)),</span>
+<span id="cb10-117"><a href="#cb10-117"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATC1"</span>)</span>
+<span id="cb10-118"><a href="#cb10-118"></a>      ),</span>
+<span id="cb10-119"><a href="#cb10-119"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-120"><a href="#cb10-120"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adcm, <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)),</span>
+<span id="cb10-121"><a href="#cb10-121"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"CMDECOD"</span>)</span>
+<span id="cb10-122"><a href="#cb10-122"></a>      ),</span>
+<span id="cb10-123"><a href="#cb10-123"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-124"><a href="#cb10-124"></a>      <span class="at">event_type =</span> <span class="st">"treatment"</span></span>
+<span id="cb10-125"><a href="#cb10-125"></a>    )</span>
+<span id="cb10-126"><a href="#cb10-126"></a>  ),</span>
+<span id="cb10-127"><a href="#cb10-127"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb10-128"><a href="#cb10-128"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb10-129"><a href="#cb10-129"></a>    <span class="at">ADCM =</span> <span class="fu">list</span>(<span class="at">ATIREL =</span> <span class="st">"CONCOMITANT"</span>)</span>
+<span id="cb10-130"><a href="#cb10-130"></a>  )</span>
+<span id="cb10-131"><a href="#cb10-131"></a>)</span>
+<span id="cb10-132"><a href="#cb10-132"></a></span>
+<span id="cb10-133"><a href="#cb10-133"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-134"><a href="#cb10-134"></a><span class="in">```</span></span>
+<span id="cb10-135"><a href="#cb10-135"></a></span>
+<span id="cb10-136"><a href="#cb10-136"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-137"><a href="#cb10-137"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
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\ No newline at end of file
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+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - DTHT01</title>
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+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+      <div class="navbar-brand-container">
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+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
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+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/deaths/dtht01.html">Deaths</a></li><li class="breadcrumb-item"><a href="../../tables/deaths/dtht01.html">DTHT01</a></li></ol></nav>
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+      </a>
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+  </nav></header><!-- content --><div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-full page-navbar">
+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="true">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+<div class="quarto-title-block"><div><h1 class="title">DTHT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Deaths</p>
+</div>
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+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table for Studies Collecting Death <br> Information from Public Records</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table Adding Details for “All other causes” <br> Category for Studies Collecting Death <br> Information from Public Records</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dtht01_cache/html/setup_7238913b0be0c0eff6df21c6e6dfa3bb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Reorder the levels in "DTHCAT" to put Other category at the end.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adsl<span class="sc">$</span>DTHCAT <span class="ot">&lt;-</span> <span class="fu">factor</span>(adsl<span class="sc">$</span>DTHCAT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"PROGRESSIVE DISEASE"</span>, <span class="st">"OTHER"</span>, <span class="st">"&lt;Missing&gt;"</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="dtht01_cache/html/variant1_ef805c20c5e3701c566420e4389547b8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>), <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>))</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                         A: Drug X    B: Placebo   C: Combination   All Patients
+                          (N=134)      (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————
+Total number of deaths   25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+Primary Cause of Death                                                          
+  n                          25           23             22              70     
+  ADVERSE EVENT           9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) 
+  PROGRESSIVE DISEASE     8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) 
+  OTHER                   8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="dtht01_cache/html/variant2_3ae87f58ee082ac87cddcc0d72b45e46">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>), <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DTHCAT"</span>, <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> 2L),</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">vars =</span> <span class="st">"LDDTHGR1"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">var_labels =</span> <span class="st">"Days from last drug administration"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="st">"LDDTHGR1"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"&lt;Missing&gt;"</span>),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">split_label =</span> <span class="st">"Primary cause by days from last study drug administration"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  <span class="fu">analyze_vars</span>(<span class="st">"DTHCAT"</span>)</span>
+<span id="cb4-30"><a href="#cb4-30"></a></span>
+<span id="cb4-31"><a href="#cb4-31"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl) <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb4-32"><a href="#cb4-32"></a></span>
+<span id="cb4-33"><a href="#cb4-33"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                            A: Drug X    B: Placebo   C: Combination   All Patients
+                                                             (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of deaths                                      25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+Primary Cause of Death                                                                                             
+  n                                                             25           23             22              70     
+  ADVERSE EVENT                                              9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) 
+  PROGRESSIVE DISEASE                                        8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) 
+  OTHER                                                      8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) 
+    LOST TO FOLLOW UP                                        2 (25%)      2 (20%)       2 (33.3%)        6 (25%)   
+    MISSING                                                  2 (25%)      3 (30%)       2 (33.3%)       7 (29.2%)  
+    Post-study reporting of death                           1 (12.5%)     2 (20%)       1 (16.7%)       4 (16.7%)  
+    SUICIDE                                                  2 (25%)      2 (20%)       1 (16.7%)       5 (20.8%)  
+    UNKNOWN                                                 1 (12.5%)     1 (10%)           0            2 (8.3%)  
+Days from last drug administration                                                                                 
+  n                                                             25           23             22              70     
+  &lt;=30                                                       14 (56%)    11 (47.8%)     14 (63.6%)      39 (55.7%) 
+  &gt;30                                                        11 (44%)    12 (52.2%)     8 (36.4%)       31 (44.3%) 
+Primary cause by days from last study drug administration                                                          
+  &lt;=30                                                                                                             
+    n                                                           14           11             14              39     
+    ADVERSE EVENT                                           4 (28.6%)    2 (18.2%)      6 (42.9%)       12 (30.8%) 
+    PROGRESSIVE DISEASE                                     6 (42.9%)    3 (27.3%)      4 (28.6%)       13 (33.3%) 
+    OTHER                                                   4 (28.6%)    6 (54.5%)      4 (28.6%)       14 (35.9%) 
+  &gt;30                                                                                                              
+    n                                                           11           12             8               31     
+    ADVERSE EVENT                                           5 (45.5%)    5 (41.7%)       4 (50%)        14 (45.2%) 
+    PROGRESSIVE DISEASE                                     2 (18.2%)     3 (25%)        2 (25%)        7 (22.6%)  
+    OTHER                                                   4 (36.4%)    4 (33.3%)       2 (25%)        10 (32.3%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="dtht01_cache/html/variant3_576ec479b5fa55ae8892acecfa404a01">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>dthcaus_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(adsl[adsl<span class="sc">$</span>DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span>, ]<span class="sc">$</span>DTHCAUS)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>),</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">table_names =</span> <span class="st">"primary_cause"</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="st">"DTHCAT"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>),</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">values =</span> dthcaus_levels[<span class="dv">5</span>],</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Post-study reportings of death"</span>),</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">table_names =</span> <span class="st">"post_study_deaths"</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">values =</span> dthcaus_levels[<span class="sc">-</span><span class="dv">5</span>],</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"All other causes"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">table_names =</span> <span class="st">"all_other_causes"</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>  )</span>
+<span id="cb6-37"><a href="#cb6-37"></a></span>
+<span id="cb6-38"><a href="#cb6-38"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb6-39"><a href="#cb6-39"></a></span>
+<span id="cb6-40"><a href="#cb6-40"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     A: Drug X    B: Placebo   C: Combination   All Patients
+                                      (N=134)      (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————————
+Total number of deaths               25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+Primary Cause of Death                                                                      
+  n                                      25           23             22              70     
+  ADVERSE EVENT                       9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) 
+  PROGRESSIVE DISEASE                 8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) 
+  OTHER                               8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) 
+    Post-study reportings of death   1 (12.5%)    2 (20.0%)      1 (16.7%)       4 (16.7%)  
+    All other causes                 7 (87.5%)    8 (80.0%)      5 (83.3%)       20 (83.3%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="dtht01_cache/html/variant4_628e332d7ed56a5c442a627f52e57f1f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>dthcaus_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(adsl[adsl<span class="sc">$</span>DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span>, ]<span class="sc">$</span>DTHCAUS)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="co"># create a helper variable DTHCAUS_other</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">DTHCAUS_other =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(</span>
+<span id="cb8-7"><a href="#cb8-7"></a>      DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span> <span class="sc">&amp;</span> DTHCAUS <span class="sc">!=</span> <span class="st">"Post-study reporting of death"</span>, <span class="fu">as.character</span>(DTHCAUS), <span class="cn">NA</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOST TO FOLLOW UP"</span>, <span class="st">"SUICIDE"</span>, <span class="st">"UNKNOWN"</span>, <span class="st">"MISSING"</span>)) <span class="sc">%&gt;%</span> <span class="fu">explicit_na</span>()</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  )</span>
+<span id="cb8-10"><a href="#cb8-10"></a></span>
+<span id="cb8-11"><a href="#cb8-11"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb8-18"><a href="#cb8-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-19"><a href="#cb8-19"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>),</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">table_names =</span> <span class="st">"primary_cause"</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DTHCAT"</span>, <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="at">values =</span> dthcaus_levels[<span class="dv">5</span>],</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Post-study reportings of death"</span>),</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">table_names =</span> <span class="st">"post_study_deaths"</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>    <span class="at">values =</span> dthcaus_levels[<span class="sc">-</span><span class="dv">5</span>],</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"All other causes"</span>),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">table_names =</span> <span class="st">"all_other_causes"</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="st">"DTHCAUS_other"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> 3L),</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  )</span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb8-49"><a href="#cb8-49"></a></span>
+<span id="cb8-50"><a href="#cb8-50"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     A: Drug X    B: Placebo   C: Combination   All Patients
+                                      (N=134)      (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————————
+Total number of deaths               25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+Primary Cause of Death                                                                      
+  n                                      25           23             22              70     
+  ADVERSE EVENT                       9 (36%)     7 (30.4%)      10 (45.5%)      26 (37.1%) 
+  PROGRESSIVE DISEASE                 8 (32%)     6 (26.1%)      6 (27.3%)       20 (28.6%) 
+  OTHER                               8 (32%)     10 (43.5%)     6 (27.3%)       24 (34.3%) 
+    Post-study reportings of death   1 (12.5%)    2 (20.0%)      1 (16.7%)       4 (16.7%)  
+    All other causes                 7 (87.5%)    8 (80.0%)      5 (83.3%)       20 (83.3%) 
+      LOST TO FOLLOW UP              2 (28.6%)     2 (25%)        2 (40%)         6 (30%)   
+      SUICIDE                        2 (28.6%)     2 (25%)        1 (20%)         5 (25%)   
+      UNKNOWN                        1 (14.3%)    1 (12.5%)          0            2 (10%)   
+      MISSING                        2 (28.6%)    3 (37.5%)       2 (40%)         7 (35%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="dtht01_cache/html/teal_bc3cc561203a4243139879e1096de87d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dtht01_cache/html/sessioninfo_ab9d6f0a21505c64ceda58c527a5f386">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dtht01_cache/html/snapshot_74c5e8d7763f4e37f4e110cf187cefe6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/deaths/dtht01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
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+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> DTHT01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Deaths</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a></span>
+<span id="cb14-20"><a href="#cb14-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-21"><a href="#cb14-21"></a></span>
+<span id="cb14-22"><a href="#cb14-22"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-23"><a href="#cb14-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-24"><a href="#cb14-24"></a></span>
+<span id="cb14-25"><a href="#cb14-25"></a><span class="co"># Reorder the levels in "DTHCAT" to put Other category at the end.</span></span>
+<span id="cb14-26"><a href="#cb14-26"></a>adsl<span class="sc">$</span>DTHCAT <span class="ot">&lt;-</span> <span class="fu">factor</span>(adsl<span class="sc">$</span>DTHCAT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"PROGRESSIVE DISEASE"</span>, <span class="st">"OTHER"</span>, <span class="st">"&lt;Missing&gt;"</span>))</span>
+<span id="cb14-27"><a href="#cb14-27"></a><span class="in">```</span></span>
+<span id="cb14-28"><a href="#cb14-28"></a></span>
+<span id="cb14-29"><a href="#cb14-29"></a><span class="fu">## Standard Table</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a></span>
+<span id="cb14-31"><a href="#cb14-31"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb14-32"><a href="#cb14-32"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-33"><a href="#cb14-33"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-34"><a href="#cb14-34"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-35"><a href="#cb14-35"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb14-36"><a href="#cb14-36"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-37"><a href="#cb14-37"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb14-38"><a href="#cb14-38"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb14-39"><a href="#cb14-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>), <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>))</span>
+<span id="cb14-41"><a href="#cb14-41"></a></span>
+<span id="cb14-42"><a href="#cb14-42"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb14-43"><a href="#cb14-43"></a>result</span>
+<span id="cb14-44"><a href="#cb14-44"></a><span class="in">```</span></span>
+<span id="cb14-45"><a href="#cb14-45"></a></span>
+<span id="cb14-46"><a href="#cb14-46"></a><span class="fu">## Table Selecting &lt;br/&gt; Sections to Display</span></span>
+<span id="cb14-47"><a href="#cb14-47"></a></span>
+<span id="cb14-48"><a href="#cb14-48"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb14-49"><a href="#cb14-49"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-51"><a href="#cb14-51"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-52"><a href="#cb14-52"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb14-53"><a href="#cb14-53"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-54"><a href="#cb14-54"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb14-55"><a href="#cb14-55"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb14-56"><a href="#cb14-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>), <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DTHCAT"</span>, <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-59"><a href="#cb14-59"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-60"><a href="#cb14-60"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb14-61"><a href="#cb14-61"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-62"><a href="#cb14-62"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> 2L),</span>
+<span id="cb14-63"><a href="#cb14-63"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-65"><a href="#cb14-65"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-66"><a href="#cb14-66"></a>    <span class="at">vars =</span> <span class="st">"LDDTHGR1"</span>,</span>
+<span id="cb14-67"><a href="#cb14-67"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-68"><a href="#cb14-68"></a>    <span class="at">var_labels =</span> <span class="st">"Days from last drug administration"</span>,</span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-71"><a href="#cb14-71"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb14-72"><a href="#cb14-72"></a>    <span class="st">"LDDTHGR1"</span>,</span>
+<span id="cb14-73"><a href="#cb14-73"></a>    <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"&lt;Missing&gt;"</span>),</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="at">split_label =</span> <span class="st">"Primary cause by days from last study drug administration"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span></span>
+<span id="cb14-76"><a href="#cb14-76"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>  <span class="fu">analyze_vars</span>(<span class="st">"DTHCAT"</span>)</span>
+<span id="cb14-78"><a href="#cb14-78"></a></span>
+<span id="cb14-79"><a href="#cb14-79"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl) <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb14-80"><a href="#cb14-80"></a></span>
+<span id="cb14-81"><a href="#cb14-81"></a>result</span>
+<span id="cb14-82"><a href="#cb14-82"></a><span class="in">```</span></span>
+<span id="cb14-83"><a href="#cb14-83"></a></span>
+<span id="cb14-84"><a href="#cb14-84"></a><span class="fu">## Table for Studies Collecting Death &lt;br/&gt; Information from Public Records</span></span>
+<span id="cb14-85"><a href="#cb14-85"></a></span>
+<span id="cb14-86"><a href="#cb14-86"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb14-87"><a href="#cb14-87"></a>dthcaus_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(adsl[adsl<span class="sc">$</span>DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span>, ]<span class="sc">$</span>DTHCAUS)</span>
+<span id="cb14-88"><a href="#cb14-88"></a></span>
+<span id="cb14-89"><a href="#cb14-89"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-90"><a href="#cb14-90"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-91"><a href="#cb14-91"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-92"><a href="#cb14-92"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb14-93"><a href="#cb14-93"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-94"><a href="#cb14-94"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb14-95"><a href="#cb14-95"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb14-96"><a href="#cb14-96"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-97"><a href="#cb14-97"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-98"><a href="#cb14-98"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>),</span>
+<span id="cb14-99"><a href="#cb14-99"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>),</span>
+<span id="cb14-100"><a href="#cb14-100"></a>    <span class="at">table_names =</span> <span class="st">"primary_cause"</span></span>
+<span id="cb14-101"><a href="#cb14-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-102"><a href="#cb14-102"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb14-103"><a href="#cb14-103"></a>    <span class="st">"DTHCAT"</span>,</span>
+<span id="cb14-104"><a href="#cb14-104"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>),</span>
+<span id="cb14-105"><a href="#cb14-105"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-107"><a href="#cb14-107"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-108"><a href="#cb14-108"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">values =</span> dthcaus_levels[<span class="dv">5</span>],</span>
+<span id="cb14-110"><a href="#cb14-110"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Post-study reportings of death"</span>),</span>
+<span id="cb14-111"><a href="#cb14-111"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb14-112"><a href="#cb14-112"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb14-113"><a href="#cb14-113"></a>    <span class="at">table_names =</span> <span class="st">"post_study_deaths"</span></span>
+<span id="cb14-114"><a href="#cb14-114"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-115"><a href="#cb14-115"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-116"><a href="#cb14-116"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb14-117"><a href="#cb14-117"></a>    <span class="at">values =</span> dthcaus_levels[<span class="sc">-</span><span class="dv">5</span>],</span>
+<span id="cb14-118"><a href="#cb14-118"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"All other causes"</span>),</span>
+<span id="cb14-119"><a href="#cb14-119"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb14-120"><a href="#cb14-120"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb14-121"><a href="#cb14-121"></a>    <span class="at">table_names =</span> <span class="st">"all_other_causes"</span></span>
+<span id="cb14-122"><a href="#cb14-122"></a>  )</span>
+<span id="cb14-123"><a href="#cb14-123"></a></span>
+<span id="cb14-124"><a href="#cb14-124"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb14-125"><a href="#cb14-125"></a></span>
+<span id="cb14-126"><a href="#cb14-126"></a>result</span>
+<span id="cb14-127"><a href="#cb14-127"></a><span class="in">```</span></span>
+<span id="cb14-128"><a href="#cb14-128"></a></span>
+<span id="cb14-129"><a href="#cb14-129"></a><span class="fu">## Table Adding Details for "All other causes" &lt;br/&gt; Category for Studies Collecting Death &lt;br/&gt; Information from Public Records</span></span>
+<span id="cb14-130"><a href="#cb14-130"></a></span>
+<span id="cb14-131"><a href="#cb14-131"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb14-132"><a href="#cb14-132"></a>dthcaus_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(adsl[adsl<span class="sc">$</span>DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span>, ]<span class="sc">$</span>DTHCAUS)</span>
+<span id="cb14-133"><a href="#cb14-133"></a></span>
+<span id="cb14-134"><a href="#cb14-134"></a><span class="co"># create a helper variable DTHCAUS_other</span></span>
+<span id="cb14-135"><a href="#cb14-135"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-136"><a href="#cb14-136"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-137"><a href="#cb14-137"></a>    <span class="at">DTHCAUS_other =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(</span>
+<span id="cb14-138"><a href="#cb14-138"></a>      DTHCAT <span class="sc">==</span> <span class="st">"OTHER"</span> <span class="sc">&amp;</span> DTHCAUS <span class="sc">!=</span> <span class="st">"Post-study reporting of death"</span>, <span class="fu">as.character</span>(DTHCAUS), <span class="cn">NA</span></span>
+<span id="cb14-139"><a href="#cb14-139"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOST TO FOLLOW UP"</span>, <span class="st">"SUICIDE"</span>, <span class="st">"UNKNOWN"</span>, <span class="st">"MISSING"</span>)) <span class="sc">%&gt;%</span> <span class="fu">explicit_na</span>()</span>
+<span id="cb14-140"><a href="#cb14-140"></a>  )</span>
+<span id="cb14-141"><a href="#cb14-141"></a></span>
+<span id="cb14-142"><a href="#cb14-142"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-143"><a href="#cb14-143"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-144"><a href="#cb14-144"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-145"><a href="#cb14-145"></a>    <span class="st">"DTHFL"</span>,</span>
+<span id="cb14-146"><a href="#cb14-146"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-147"><a href="#cb14-147"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total number of deaths"</span>),</span>
+<span id="cb14-148"><a href="#cb14-148"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>)</span>
+<span id="cb14-149"><a href="#cb14-149"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-150"><a href="#cb14-150"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-151"><a href="#cb14-151"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"DTHCAT"</span>),</span>
+<span id="cb14-152"><a href="#cb14-152"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Primary Cause of Death"</span>),</span>
+<span id="cb14-153"><a href="#cb14-153"></a>    <span class="at">table_names =</span> <span class="st">"primary_cause"</span></span>
+<span id="cb14-154"><a href="#cb14-154"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-155"><a href="#cb14-155"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DTHCAT"</span>, <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"OTHER"</span>), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-156"><a href="#cb14-156"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-157"><a href="#cb14-157"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb14-158"><a href="#cb14-158"></a>    <span class="at">values =</span> dthcaus_levels[<span class="dv">5</span>],</span>
+<span id="cb14-159"><a href="#cb14-159"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Post-study reportings of death"</span>),</span>
+<span id="cb14-160"><a href="#cb14-160"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb14-161"><a href="#cb14-161"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb14-162"><a href="#cb14-162"></a>    <span class="at">table_names =</span> <span class="st">"post_study_deaths"</span></span>
+<span id="cb14-163"><a href="#cb14-163"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-164"><a href="#cb14-164"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb14-165"><a href="#cb14-165"></a>    <span class="st">"DTHCAUS"</span>,</span>
+<span id="cb14-166"><a href="#cb14-166"></a>    <span class="at">values =</span> dthcaus_levels[<span class="sc">-</span><span class="dv">5</span>],</span>
+<span id="cb14-167"><a href="#cb14-167"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"All other causes"</span>),</span>
+<span id="cb14-168"><a href="#cb14-168"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.x%)"</span>),</span>
+<span id="cb14-169"><a href="#cb14-169"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 2L),</span>
+<span id="cb14-170"><a href="#cb14-170"></a>    <span class="at">table_names =</span> <span class="st">"all_other_causes"</span></span>
+<span id="cb14-171"><a href="#cb14-171"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-172"><a href="#cb14-172"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-173"><a href="#cb14-173"></a>    <span class="st">"DTHCAUS_other"</span>,</span>
+<span id="cb14-174"><a href="#cb14-174"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-175"><a href="#cb14-175"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> 3L),</span>
+<span id="cb14-176"><a href="#cb14-176"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-177"><a href="#cb14-177"></a>  )</span>
+<span id="cb14-178"><a href="#cb14-178"></a></span>
+<span id="cb14-179"><a href="#cb14-179"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb14-180"><a href="#cb14-180"></a></span>
+<span id="cb14-181"><a href="#cb14-181"></a>result</span>
+<span id="cb14-182"><a href="#cb14-182"></a><span class="in">```</span></span>
+<span id="cb14-183"><a href="#cb14-183"></a></span>
+<span id="cb14-184"><a href="#cb14-184"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-185"><a href="#cb14-185"></a></span>
+<span id="cb14-186"><a href="#cb14-186"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-187"><a href="#cb14-187"></a></span>
+<span id="cb14-188"><a href="#cb14-188"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-189"><a href="#cb14-189"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-190"><a href="#cb14-190"></a></span>
+<span id="cb14-191"><a href="#cb14-191"></a><span class="co"># In progress</span></span>
+<span id="cb14-192"><a href="#cb14-192"></a><span class="in">```</span></span>
+<span id="cb14-193"><a href="#cb14-193"></a></span>
+<span id="cb14-194"><a href="#cb14-194"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-195"><a href="#cb14-195"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
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diff --git a/stable/tables/demography/dmt01.html b/stable/tables/demography/dmt01.html
new file mode 100644
index 0000000000..4acb318469
--- /dev/null
+++ b/stable/tables/demography/dmt01.html
@@ -0,0 +1,2605 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - DMT01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/disclosures/disclosurest01.html" rel="next">
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+ <span class="menu-text">AET01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+ <span class="menu-text">AET02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DMT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Demographics and Baseline Characteristics</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Table with an Additional <br> Study-Specific Continuous Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with an Additional <br> Study-Specific Categorical Variable</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Subgrouping <br> for Some Analyses</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Additional Vital <br> Signs Baseline Values</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table with Additional <br> Values from ADSUB</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dmt01_cache/html/setup_a49d244484f556a5a897f454240e528f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsub <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsub"</span>)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>adsub <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsub)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Change description in variable SEX.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      SEX <span class="sc">==</span> <span class="st">"U"</span> <span class="sc">~</span> <span class="st">"Unknown"</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      SEX <span class="sc">==</span> <span class="st">"UNDIFFERENTIATED"</span> <span class="sc">~</span> <span class="st">"Undifferentiated"</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>    )),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>        <span class="fu">between</span>(AGE, <span class="dv">18</span>, <span class="dv">40</span>) <span class="sc">~</span> <span class="st">"18-40"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>        <span class="fu">between</span>(AGE, <span class="dv">41</span>, <span class="dv">64</span>) <span class="sc">~</span> <span class="st">"41-64"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>        AGE <span class="sc">&gt;</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>      ),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"18-40"</span>, <span class="st">"41-64"</span>, <span class="st">"&gt;=65"</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    ),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">BMRKR1_CAT =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>        BMRKR1 <span class="sc">&lt;</span> <span class="fl">3.5</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>        BMRKR1 <span class="sc">&gt;=</span> <span class="fl">3.5</span> <span class="sc">&amp;</span> BMRKR1 <span class="sc">&lt;</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"MEDIUM"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>        BMRKR1 <span class="sc">&gt;=</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"HIGH"</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>      ),</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"MEDIUM"</span>, <span class="st">"HIGH"</span>)</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    )</span>
+<span id="cb1-40"><a href="#cb1-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    <span class="at">BMRKR1_CAT =</span> <span class="st">"Biomarker 1 Categories"</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  )</span>
+<span id="cb1-44"><a href="#cb1-44"></a><span class="co"># The developer needs to do pre-processing to add necessary variables based on ADVS to analysis dataset.</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a><span class="co"># Obtain SBP, DBP and weight.</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>get_param_advs <span class="ot">&lt;-</span> <span class="cf">function</span>(pname, plabel) {</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  ds <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="fu">filter</span>(PARAM <span class="sc">==</span> plabel <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="fu">select</span>(USUBJID, AVAL)</span>
+<span id="cb1-50"><a href="#cb1-50"></a></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">colnames</span>(ds) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, pname)</span>
+<span id="cb1-52"><a href="#cb1-52"></a></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  ds</span>
+<span id="cb1-54"><a href="#cb1-54"></a>}</span>
+<span id="cb1-55"><a href="#cb1-55"></a><span class="co"># The developer needs to do pre-processing to add necessary variables based on ADSUB to analysis dataset.</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a><span class="co"># Obtain baseline BMI (BBMISI).</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>get_param_adsub <span class="ot">&lt;-</span> <span class="cf">function</span>(pname, plabel) {</span>
+<span id="cb1-58"><a href="#cb1-58"></a>  ds <span class="ot">&lt;-</span> adsub <span class="sc">%&gt;%</span></span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="fu">filter</span>(PARAM <span class="sc">==</span> plabel) <span class="sc">%&gt;%</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>    <span class="fu">select</span>(USUBJID, AVAL)</span>
+<span id="cb1-61"><a href="#cb1-61"></a></span>
+<span id="cb1-62"><a href="#cb1-62"></a>  <span class="fu">colnames</span>(ds) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, pname)</span>
+<span id="cb1-63"><a href="#cb1-63"></a></span>
+<span id="cb1-64"><a href="#cb1-64"></a>  ds</span>
+<span id="cb1-65"><a href="#cb1-65"></a>}</span>
+<span id="cb1-66"><a href="#cb1-66"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-67"><a href="#cb1-67"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"SBP"</span>, <span class="st">"Systolic Blood Pressure"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-68"><a href="#cb1-68"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"DBP"</span>, <span class="st">"Diastolic Blood Pressure"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"WGT"</span>, <span class="st">"Weight"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-70"><a href="#cb1-70"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_adsub</span>(<span class="st">"BBMISI"</span>, <span class="st">"Baseline BMI"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="dmt01_cache/html/variant1_518c79e24674807eac2e80f931fa793c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGR1"</span>, <span class="st">"SEX"</span>, <span class="st">"ETHNIC"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR1"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="st">"Age (yr)"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="st">"Age Group"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="st">"Sex"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="st">"Ethnicity"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="st">"Race"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="st">"Continous Level Biomarker 1"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb2-19"><a href="#cb2-19"></a></span>
+<span id="cb2-20"><a href="#cb2-20"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X    B: Placebo    C: Combination   All Patients
+                                                (N=134)       (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————————————————————————
+Age (yr)                                                                                               
+  n                                               134           134            132             400     
+  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)      34.9 (7.4) 
+  Median                                         33.0          35.0            35.0            34.0    
+  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0     20.0 - 69.0 
+Age Group                                                                                              
+  n                                               134           134            132             400     
+  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)     322 (80.5%) 
+  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)      77 (19.2%) 
+  &gt;=65                                             0             0           1 (0.8%)        1 (0.2%)  
+Sex                                                                                                    
+  n                                               134           134            132             400     
+  Female                                       79 (59%)     82 (61.2%)       70 (53%)      231 (57.8%) 
+  Male                                         55 (41%)     52 (38.8%)       62 (47%)      169 (42.2%) 
+Ethnicity                                                                                              
+  n                                               134           134            132             400     
+  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)       27 (6.8%)  
+  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)       48 (12%)  
+  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)      308 (77%)  
+  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)       17 (4.2%)  
+Race                                                                                                   
+  n                                               134           134            132             400     
+  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)      208 (52%)  
+  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)      91 (22.8%) 
+  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)      74 (18.5%) 
+  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)       25 (6.2%)  
+  MULTIPLE                                         0         1 (0.7%)           0            1 (0.2%)  
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0            1 (0.2%)  
+  OTHER                                            0             0              0               0      
+  UNKNOWN                                          0             0              0               0      
+Continous Level Biomarker 1                                                                            
+  n                                               134           134            132             400     
+  Mean (SD)                                    6.0 (3.6)     5.7 (3.3)      5.6 (3.5)       5.8 (3.4)  
+  Median                                          5.4           4.8            4.6             4.8     
+  Min - Max                                   0.4 - 17.7    0.6 - 14.2      0.2 - 21.4      0.2 - 21.4 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="dmt01_cache/html/variant2_7b4b442b48f56f446564a486a6cf0bad">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGR1"</span>, <span class="st">"SEX"</span>, <span class="st">"ETHNIC"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR1_CAT"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="st">"Age (yr)"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="st">"Age Group"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="st">"Sex"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="st">"Ethnicity"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="st">"Race"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="st">"Biomarker 1 Categories"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>)</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb4-18"><a href="#cb4-18"></a></span>
+<span id="cb4-19"><a href="#cb4-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X    B: Placebo    C: Combination
+                                                (N=134)       (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————
+Age (yr)                                                                                
+  n                                               134           134            132      
+  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)  
+  Median                                         33.0          35.0            35.0     
+  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0  
+Age Group                                                                               
+  n                                               134           134            132      
+  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)  
+  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)  
+  &gt;=65                                             0             0           1 (0.8%)   
+Sex                                                                                     
+  n                                               134           134            132      
+  Female                                       79 (59%)     82 (61.2%)       70 (53%)   
+  Male                                         55 (41%)     52 (38.8%)       62 (47%)   
+Ethnicity                                                                               
+  n                                               134           134            132      
+  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)   
+  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)  
+  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)  
+  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)   
+Race                                                                                    
+  n                                               134           134            132      
+  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)  
+  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)  
+  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)  
+  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)   
+  MULTIPLE                                         0         1 (0.7%)           0       
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0       
+  OTHER                                            0             0              0       
+  UNKNOWN                                          0             0              0       
+Biomarker 1 Categories                                                                  
+  n                                               134           134            132      
+  LOW                                         33 (24.6%)    41 (30.6%)      38 (28.8%)  
+  MEDIUM                                      84 (62.7%)    76 (56.7%)      80 (60.6%)  
+  HIGH                                        17 (12.7%)    17 (12.7%)      14 (10.6%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="dmt01_cache/html/variant3_1e0b2744cfc4e96d2f62ff227c5627a9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>),</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Age"</span>, <span class="st">"Sex"</span>, <span class="st">"Race"</span>)</span>
+<span id="cb6-8"><a href="#cb6-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"STRATA1"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">split_fun =</span> split_fun</span>
+<span id="cb6-11"><a href="#cb6-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BMRKR1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb6-14"><a href="#cb6-14"></a></span>
+<span id="cb6-15"><a href="#cb6-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X    B: Placebo    C: Combination
+                                                (N=134)       (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————
+Age                                                                                     
+  n                                               134           134            132      
+  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)  
+  Median                                         33.0          35.0            35.0     
+  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0  
+Sex                                                                                     
+  n                                               134           134            132      
+  Female                                       79 (59%)     82 (61.2%)       70 (53%)   
+  Male                                         55 (41%)     52 (38.8%)       62 (47%)   
+Race                                                                                    
+  n                                               134           134            132      
+  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)  
+  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)  
+  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)  
+  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)   
+  MULTIPLE                                         0         1 (0.7%)           0       
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0       
+  OTHER                                            0             0              0       
+  UNKNOWN                                          0             0              0       
+A                                                                                       
+  n                                               38            44              40      
+  Mean (SD)                                    5.8 (3.8)     5.4 (3.2)      5.1 (3.2)   
+  Median                                          5.1           4.5            3.8      
+  Min - Max                                   0.4 - 17.7    1.4 - 14.2      1.5 - 14.0  
+B                                                                                       
+  n                                               47            45              43      
+  Mean (SD)                                    6.1 (3.6)     5.8 (3.6)      5.7 (3.4)   
+  Median                                          5.2           4.8            5.1      
+  Min - Max                                   1.6 - 17.2    0.6 - 13.3      0.2 - 16.5  
+C                                                                                       
+  n                                               49            45              49      
+  Mean (SD)                                    6.0 (3.4)     5.9 (3.2)      6.0 (3.8)   
+  Median                                          5.8           5.6            4.5      
+  Min - Max                                   0.5 - 15.1    1.5 - 13.9      1.2 - 21.4  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="dmt01_cache/html/variant4_c6f39d6e288938ef42effb4d510057f2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"DBP"</span>, <span class="st">"SBP"</span>),</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-6"><a href="#cb8-6"></a>      <span class="st">"Age (yr)"</span>,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>      <span class="st">"Sex"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>      <span class="st">"Race"</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>      <span class="st">"Diastolic Blood Pressure"</span>,</span>
+<span id="cb8-10"><a href="#cb8-10"></a>      <span class="st">"Systolic Blood Pressure"</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>    )</span>
+<span id="cb8-12"><a href="#cb8-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X      B: Placebo    C: Combination
+                                                (N=134)        (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————
+Age (yr)                                                                                  
+  n                                               134            134             132      
+  Mean (SD)                                    33.8 (6.6)     35.4 (7.9)      35.4 (7.7)  
+  Median                                          33.0           35.0            35.0     
+  Min - Max                                   21.0 - 50.0    21.0 - 62.0     20.0 - 69.0  
+Sex                                                                                       
+  n                                               134            134             132      
+  Female                                        79 (59%)      82 (61.2%)       70 (53%)   
+  Male                                          55 (41%)      52 (38.8%)       62 (47%)   
+Race                                                                                      
+  n                                               134            134             132      
+  ASIAN                                        68 (50.7%)      67 (50%)       73 (55.3%)  
+  BLACK OR AFRICAN AMERICAN                    31 (23.1%)     28 (20.9%)      32 (24.2%)  
+  WHITE                                        27 (20.1%)     26 (19.4%)      21 (15.9%)  
+  AMERICAN INDIAN OR ALASKA NATIVE               8 (6%)       11 (8.2%)        6 (4.5%)   
+  MULTIPLE                                         0           1 (0.7%)           0       
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0           1 (0.7%)           0       
+  OTHER                                            0              0               0       
+  UNKNOWN                                          0              0               0       
+Diastolic Blood Pressure                                                                  
+  n                                               134            134             132      
+  Mean (SD)                                   96.5 (19.9)    101.1 (19.9)    102.8 (19.5) 
+  Median                                          96.0          100.4           102.0     
+  Min - Max                                   44.3 - 136.6   29.2 - 143.8    49.4 - 153.5 
+Systolic Blood Pressure                                                                   
+  n                                               134            134             132      
+  Mean (SD)                                   151.7 (31.5)   149.5 (26.5)    144.7 (30.1) 
+  Median                                         150.1          153.0           146.5     
+  Min - Max                                   69.1 - 231.2   87.2 - 220.9    71.8 - 220.2 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="dmt01_cache/html/variant5_0d14028caa1ff3654a4110a1ba14ce62">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb10-4"><a href="#cb10-4"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"BBMISI"</span>),</span>
+<span id="cb10-5"><a href="#cb10-5"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-6"><a href="#cb10-6"></a>      <span class="st">"Age (yr)"</span>,</span>
+<span id="cb10-7"><a href="#cb10-7"></a>      <span class="st">"Sex"</span>,</span>
+<span id="cb10-8"><a href="#cb10-8"></a>      <span class="st">"Race"</span>,</span>
+<span id="cb10-9"><a href="#cb10-9"></a>      <span class="st">"Baseline BMI"</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>    )</span>
+<span id="cb10-11"><a href="#cb10-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb10-13"><a href="#cb10-13"></a></span>
+<span id="cb10-14"><a href="#cb10-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X     B: Placebo     C: Combination
+                                                (N=134)        (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————
+Age (yr)                                                                                  
+  n                                               134            134             132      
+  Mean (SD)                                   33.8 (6.6)     35.4 (7.9)       35.4 (7.7)  
+  Median                                         33.0           35.0             35.0     
+  Min - Max                                   21.0 - 50.0    21.0 - 62.0     20.0 - 69.0  
+Sex                                                                                       
+  n                                               134            134             132      
+  Female                                       79 (59%)      82 (61.2%)        70 (53%)   
+  Male                                         55 (41%)      52 (38.8%)        62 (47%)   
+Race                                                                                      
+  n                                               134            134             132      
+  ASIAN                                       68 (50.7%)      67 (50%)        73 (55.3%)  
+  BLACK OR AFRICAN AMERICAN                   31 (23.1%)     28 (20.9%)       32 (24.2%)  
+  WHITE                                       27 (20.1%)     26 (19.4%)       21 (15.9%)  
+  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)        11 (8.2%)        6 (4.5%)   
+  MULTIPLE                                         0          1 (0.7%)            0       
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0          1 (0.7%)            0       
+  OTHER                                            0              0               0       
+  UNKNOWN                                          0              0               0       
+Baseline BMI                                                                              
+  n                                               134            134             132      
+  Mean (SD)                                   30.0 (18.3)    32.4 (23.2)     30.1 (18.4)  
+  Median                                         27.1           31.1             30.0     
+  Min - Max                                   -6.9 - 75.9   -26.6 - 117.9    -44.2 - 87.5 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="dmt01_cache/html/teal_46c631bc3be0f45683d03202fb83cccb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-3"><a href="#cb12-3"></a></span>
+<span id="cb12-4"><a href="#cb12-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a><span class="co"># Include `EOSDY` and `DCSREAS` variables below because they contain missing data.</span></span>
+<span id="cb12-7"><a href="#cb12-7"></a><span class="fu">stopifnot</span>(</span>
+<span id="cb12-8"><a href="#cb12-8"></a>  <span class="fu">any</span>(<span class="fu">is.na</span>(adsl<span class="sc">$</span>EOSDY)),</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="fu">any</span>(<span class="fu">is.na</span>(adsl<span class="sc">$</span>DCSREAS))</span>
+<span id="cb12-10"><a href="#cb12-10"></a>)</span>
+<span id="cb12-11"><a href="#cb12-11"></a></span>
+<span id="cb12-12"><a href="#cb12-12"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-13"><a href="#cb12-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb12-15"><a href="#cb12-15"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>,</span>
+<span id="cb12-16"><a href="#cb12-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a>  ),</span>
+<span id="cb12-18"><a href="#cb12-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-19"><a href="#cb12-19"></a>    <span class="fu">tm_t_summary</span>(</span>
+<span id="cb12-20"><a href="#cb12-20"></a>      <span class="at">label =</span> <span class="st">"Demographic Table"</span>,</span>
+<span id="cb12-21"><a href="#cb12-21"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb12-22"><a href="#cb12-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb12-23"><a href="#cb12-23"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-24"><a href="#cb12-24"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR2"</span>, <span class="st">"EOSDY"</span>, <span class="st">"DCSREAS"</span>),</span>
+<span id="cb12-25"><a href="#cb12-25"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb12-26"><a href="#cb12-26"></a>      ),</span>
+<span id="cb12-27"><a href="#cb12-27"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a>    )</span>
+<span id="cb12-29"><a href="#cb12-29"></a>  )</span>
+<span id="cb12-30"><a href="#cb12-30"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:33:28.1316 pid:13285 token:[] teal.modules.clinical Initializing tm_t_summary</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="dmt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dmt01_cache/html/sessioninfo_79536924724371319337f94afd1a5b4e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tidyr_1.3.0                  dplyr_1.1.3                 
+ [9] scda_0.1.6                   tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dmt01_cache/html/snapshot_00ac619151b48ab3b6f89192005069b0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-2"><a href="#cb17-2"></a></span>
+<span id="cb17-3"><a href="#cb17-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb17-4"><a href="#cb17-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb17-5"><a href="#cb17-5"></a></span>
+<span id="cb17-6"><a href="#cb17-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb17-7"><a href="#cb17-7"></a></span>
+<span id="cb17-8"><a href="#cb17-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb17-10"><a href="#cb17-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/demography/dmt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
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+          citeDiv.classList.add('csl-entry');
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+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/deaths/dtht01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">DTHT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/disclosures/disclosurest01.html" class="pagination-link">
+        <span class="nav-page-text">DISCLOSUREST01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb18" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb18-1"><a href="#cb18-1"></a><span class="co">---</span></span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="an">title:</span><span class="co"> DMT01</span></span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="an">subtitle:</span><span class="co"> Demographics and Baseline Characteristics</span></span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="co">---</span></span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>------------------------------------------------------------------------</span>
+<span id="cb18-7"><a href="#cb18-7"></a></span>
+<span id="cb18-8"><a href="#cb18-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb18-9"><a href="#cb18-9"></a></span>
+<span id="cb18-10"><a href="#cb18-10"></a>::: panel-tabset</span>
+<span id="cb18-11"><a href="#cb18-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb18-12"><a href="#cb18-12"></a></span>
+<span id="cb18-13"><a href="#cb18-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb18-14"><a href="#cb18-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb18-15"><a href="#cb18-15"></a></span>
+<span id="cb18-16"><a href="#cb18-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb18-17"><a href="#cb18-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-18"><a href="#cb18-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-19"><a href="#cb18-19"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb18-20"><a href="#cb18-20"></a></span>
+<span id="cb18-21"><a href="#cb18-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-22"><a href="#cb18-22"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb18-23"><a href="#cb18-23"></a>adsub <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsub"</span>)</span>
+<span id="cb18-24"><a href="#cb18-24"></a></span>
+<span id="cb18-25"><a href="#cb18-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb18-26"><a href="#cb18-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb18-27"><a href="#cb18-27"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb18-28"><a href="#cb18-28"></a>adsub <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsub)</span>
+<span id="cb18-29"><a href="#cb18-29"></a></span>
+<span id="cb18-30"><a href="#cb18-30"></a><span class="co"># Change description in variable SEX.</span></span>
+<span id="cb18-31"><a href="#cb18-31"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb18-32"><a href="#cb18-32"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-33"><a href="#cb18-33"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-34"><a href="#cb18-34"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span>,</span>
+<span id="cb18-35"><a href="#cb18-35"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb18-36"><a href="#cb18-36"></a>      SEX <span class="sc">==</span> <span class="st">"U"</span> <span class="sc">~</span> <span class="st">"Unknown"</span>,</span>
+<span id="cb18-37"><a href="#cb18-37"></a>      SEX <span class="sc">==</span> <span class="st">"UNDIFFERENTIATED"</span> <span class="sc">~</span> <span class="st">"Undifferentiated"</span></span>
+<span id="cb18-38"><a href="#cb18-38"></a>    )),</span>
+<span id="cb18-39"><a href="#cb18-39"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb18-40"><a href="#cb18-40"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb18-41"><a href="#cb18-41"></a>        <span class="fu">between</span>(AGE, <span class="dv">18</span>, <span class="dv">40</span>) <span class="sc">~</span> <span class="st">"18-40"</span>,</span>
+<span id="cb18-42"><a href="#cb18-42"></a>        <span class="fu">between</span>(AGE, <span class="dv">41</span>, <span class="dv">64</span>) <span class="sc">~</span> <span class="st">"41-64"</span>,</span>
+<span id="cb18-43"><a href="#cb18-43"></a>        AGE <span class="sc">&gt;</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb18-44"><a href="#cb18-44"></a>      ),</span>
+<span id="cb18-45"><a href="#cb18-45"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"18-40"</span>, <span class="st">"41-64"</span>, <span class="st">"&gt;=65"</span>)</span>
+<span id="cb18-46"><a href="#cb18-46"></a>    ),</span>
+<span id="cb18-47"><a href="#cb18-47"></a>    <span class="at">BMRKR1_CAT =</span> <span class="fu">factor</span>(</span>
+<span id="cb18-48"><a href="#cb18-48"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb18-49"><a href="#cb18-49"></a>        BMRKR1 <span class="sc">&lt;</span> <span class="fl">3.5</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb18-50"><a href="#cb18-50"></a>        BMRKR1 <span class="sc">&gt;=</span> <span class="fl">3.5</span> <span class="sc">&amp;</span> BMRKR1 <span class="sc">&lt;</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"MEDIUM"</span>,</span>
+<span id="cb18-51"><a href="#cb18-51"></a>        BMRKR1 <span class="sc">&gt;=</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"HIGH"</span></span>
+<span id="cb18-52"><a href="#cb18-52"></a>      ),</span>
+<span id="cb18-53"><a href="#cb18-53"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"MEDIUM"</span>, <span class="st">"HIGH"</span>)</span>
+<span id="cb18-54"><a href="#cb18-54"></a>    )</span>
+<span id="cb18-55"><a href="#cb18-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-56"><a href="#cb18-56"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-57"><a href="#cb18-57"></a>    <span class="at">BMRKR1_CAT =</span> <span class="st">"Biomarker 1 Categories"</span></span>
+<span id="cb18-58"><a href="#cb18-58"></a>  )</span>
+<span id="cb18-59"><a href="#cb18-59"></a><span class="co"># The developer needs to do pre-processing to add necessary variables based on ADVS to analysis dataset.</span></span>
+<span id="cb18-60"><a href="#cb18-60"></a><span class="co"># Obtain SBP, DBP and weight.</span></span>
+<span id="cb18-61"><a href="#cb18-61"></a>get_param_advs <span class="ot">&lt;-</span> <span class="cf">function</span>(pname, plabel) {</span>
+<span id="cb18-62"><a href="#cb18-62"></a>  ds <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb18-63"><a href="#cb18-63"></a>    <span class="fu">filter</span>(PARAM <span class="sc">==</span> plabel <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-64"><a href="#cb18-64"></a>    <span class="fu">select</span>(USUBJID, AVAL)</span>
+<span id="cb18-65"><a href="#cb18-65"></a></span>
+<span id="cb18-66"><a href="#cb18-66"></a>  <span class="fu">colnames</span>(ds) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, pname)</span>
+<span id="cb18-67"><a href="#cb18-67"></a></span>
+<span id="cb18-68"><a href="#cb18-68"></a>  ds</span>
+<span id="cb18-69"><a href="#cb18-69"></a>}</span>
+<span id="cb18-70"><a href="#cb18-70"></a><span class="co"># The developer needs to do pre-processing to add necessary variables based on ADSUB to analysis dataset.</span></span>
+<span id="cb18-71"><a href="#cb18-71"></a><span class="co"># Obtain baseline BMI (BBMISI).</span></span>
+<span id="cb18-72"><a href="#cb18-72"></a>get_param_adsub <span class="ot">&lt;-</span> <span class="cf">function</span>(pname, plabel) {</span>
+<span id="cb18-73"><a href="#cb18-73"></a>  ds <span class="ot">&lt;-</span> adsub <span class="sc">%&gt;%</span></span>
+<span id="cb18-74"><a href="#cb18-74"></a>    <span class="fu">filter</span>(PARAM <span class="sc">==</span> plabel) <span class="sc">%&gt;%</span></span>
+<span id="cb18-75"><a href="#cb18-75"></a>    <span class="fu">select</span>(USUBJID, AVAL)</span>
+<span id="cb18-76"><a href="#cb18-76"></a></span>
+<span id="cb18-77"><a href="#cb18-77"></a>  <span class="fu">colnames</span>(ds) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, pname)</span>
+<span id="cb18-78"><a href="#cb18-78"></a></span>
+<span id="cb18-79"><a href="#cb18-79"></a>  ds</span>
+<span id="cb18-80"><a href="#cb18-80"></a>}</span>
+<span id="cb18-81"><a href="#cb18-81"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb18-82"><a href="#cb18-82"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"SBP"</span>, <span class="st">"Systolic Blood Pressure"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-83"><a href="#cb18-83"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"DBP"</span>, <span class="st">"Diastolic Blood Pressure"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-84"><a href="#cb18-84"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_advs</span>(<span class="st">"WGT"</span>, <span class="st">"Weight"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-85"><a href="#cb18-85"></a>  <span class="fu">left_join</span>(<span class="fu">get_param_adsub</span>(<span class="st">"BBMISI"</span>, <span class="st">"Baseline BMI"</span>), <span class="at">by =</span> <span class="st">"USUBJID"</span>)</span>
+<span id="cb18-86"><a href="#cb18-86"></a><span class="in">```</span></span>
+<span id="cb18-87"><a href="#cb18-87"></a></span>
+<span id="cb18-88"><a href="#cb18-88"></a><span class="fu">## Table with an Additional &lt;br/&gt; Study-Specific Continuous Variable</span></span>
+<span id="cb18-89"><a href="#cb18-89"></a></span>
+<span id="cb18-90"><a href="#cb18-90"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb18-91"><a href="#cb18-91"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGR1"</span>, <span class="st">"SEX"</span>, <span class="st">"ETHNIC"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR1"</span>)</span>
+<span id="cb18-92"><a href="#cb18-92"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb18-93"><a href="#cb18-93"></a>  <span class="st">"Age (yr)"</span>,</span>
+<span id="cb18-94"><a href="#cb18-94"></a>  <span class="st">"Age Group"</span>,</span>
+<span id="cb18-95"><a href="#cb18-95"></a>  <span class="st">"Sex"</span>,</span>
+<span id="cb18-96"><a href="#cb18-96"></a>  <span class="st">"Ethnicity"</span>,</span>
+<span id="cb18-97"><a href="#cb18-97"></a>  <span class="st">"Race"</span>,</span>
+<span id="cb18-98"><a href="#cb18-98"></a>  <span class="st">"Continous Level Biomarker 1"</span></span>
+<span id="cb18-99"><a href="#cb18-99"></a>)</span>
+<span id="cb18-100"><a href="#cb18-100"></a></span>
+<span id="cb18-101"><a href="#cb18-101"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-102"><a href="#cb18-102"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-103"><a href="#cb18-103"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-104"><a href="#cb18-104"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb18-105"><a href="#cb18-105"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb18-106"><a href="#cb18-106"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb18-107"><a href="#cb18-107"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-108"><a href="#cb18-108"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb18-109"><a href="#cb18-109"></a></span>
+<span id="cb18-110"><a href="#cb18-110"></a>result</span>
+<span id="cb18-111"><a href="#cb18-111"></a><span class="in">```</span></span>
+<span id="cb18-112"><a href="#cb18-112"></a></span>
+<span id="cb18-113"><a href="#cb18-113"></a><span class="fu">## Table with an Additional &lt;br/&gt; Study-Specific Categorical Variable</span></span>
+<span id="cb18-114"><a href="#cb18-114"></a></span>
+<span id="cb18-115"><a href="#cb18-115"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb18-116"><a href="#cb18-116"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGR1"</span>, <span class="st">"SEX"</span>, <span class="st">"ETHNIC"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR1_CAT"</span>)</span>
+<span id="cb18-117"><a href="#cb18-117"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(</span>
+<span id="cb18-118"><a href="#cb18-118"></a>  <span class="st">"Age (yr)"</span>,</span>
+<span id="cb18-119"><a href="#cb18-119"></a>  <span class="st">"Age Group"</span>,</span>
+<span id="cb18-120"><a href="#cb18-120"></a>  <span class="st">"Sex"</span>,</span>
+<span id="cb18-121"><a href="#cb18-121"></a>  <span class="st">"Ethnicity"</span>,</span>
+<span id="cb18-122"><a href="#cb18-122"></a>  <span class="st">"Race"</span>,</span>
+<span id="cb18-123"><a href="#cb18-123"></a>  <span class="st">"Biomarker 1 Categories"</span></span>
+<span id="cb18-124"><a href="#cb18-124"></a>)</span>
+<span id="cb18-125"><a href="#cb18-125"></a></span>
+<span id="cb18-126"><a href="#cb18-126"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-127"><a href="#cb18-127"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-128"><a href="#cb18-128"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb18-129"><a href="#cb18-129"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb18-130"><a href="#cb18-130"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb18-131"><a href="#cb18-131"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-132"><a href="#cb18-132"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb18-133"><a href="#cb18-133"></a></span>
+<span id="cb18-134"><a href="#cb18-134"></a>result</span>
+<span id="cb18-135"><a href="#cb18-135"></a><span class="in">```</span></span>
+<span id="cb18-136"><a href="#cb18-136"></a></span>
+<span id="cb18-137"><a href="#cb18-137"></a><span class="fu">## Table with Subgrouping &lt;br/&gt; for Some Analyses</span></span>
+<span id="cb18-138"><a href="#cb18-138"></a></span>
+<span id="cb18-139"><a href="#cb18-139"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb18-140"><a href="#cb18-140"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb18-141"><a href="#cb18-141"></a></span>
+<span id="cb18-142"><a href="#cb18-142"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-143"><a href="#cb18-143"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-144"><a href="#cb18-144"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb18-145"><a href="#cb18-145"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>),</span>
+<span id="cb18-146"><a href="#cb18-146"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Age"</span>, <span class="st">"Sex"</span>, <span class="st">"Race"</span>)</span>
+<span id="cb18-147"><a href="#cb18-147"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-148"><a href="#cb18-148"></a>  <span class="fu">split_rows_by</span>(<span class="st">"STRATA1"</span>,</span>
+<span id="cb18-149"><a href="#cb18-149"></a>    <span class="at">split_fun =</span> split_fun</span>
+<span id="cb18-150"><a href="#cb18-150"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-151"><a href="#cb18-151"></a>  <span class="fu">analyze_vars</span>(<span class="st">"BMRKR1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-152"><a href="#cb18-152"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb18-153"><a href="#cb18-153"></a></span>
+<span id="cb18-154"><a href="#cb18-154"></a>result</span>
+<span id="cb18-155"><a href="#cb18-155"></a><span class="in">```</span></span>
+<span id="cb18-156"><a href="#cb18-156"></a></span>
+<span id="cb18-157"><a href="#cb18-157"></a><span class="fu">## Table with Additional Vital &lt;br/&gt; Signs Baseline Values</span></span>
+<span id="cb18-158"><a href="#cb18-158"></a></span>
+<span id="cb18-159"><a href="#cb18-159"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb18-160"><a href="#cb18-160"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-161"><a href="#cb18-161"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-162"><a href="#cb18-162"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb18-163"><a href="#cb18-163"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"DBP"</span>, <span class="st">"SBP"</span>),</span>
+<span id="cb18-164"><a href="#cb18-164"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-165"><a href="#cb18-165"></a>      <span class="st">"Age (yr)"</span>,</span>
+<span id="cb18-166"><a href="#cb18-166"></a>      <span class="st">"Sex"</span>,</span>
+<span id="cb18-167"><a href="#cb18-167"></a>      <span class="st">"Race"</span>,</span>
+<span id="cb18-168"><a href="#cb18-168"></a>      <span class="st">"Diastolic Blood Pressure"</span>,</span>
+<span id="cb18-169"><a href="#cb18-169"></a>      <span class="st">"Systolic Blood Pressure"</span></span>
+<span id="cb18-170"><a href="#cb18-170"></a>    )</span>
+<span id="cb18-171"><a href="#cb18-171"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-172"><a href="#cb18-172"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb18-173"><a href="#cb18-173"></a></span>
+<span id="cb18-174"><a href="#cb18-174"></a>result</span>
+<span id="cb18-175"><a href="#cb18-175"></a><span class="in">```</span></span>
+<span id="cb18-176"><a href="#cb18-176"></a></span>
+<span id="cb18-177"><a href="#cb18-177"></a><span class="fu">## Table with Additional &lt;br/&gt; Values from ADSUB</span></span>
+<span id="cb18-178"><a href="#cb18-178"></a></span>
+<span id="cb18-179"><a href="#cb18-179"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb18-180"><a href="#cb18-180"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-181"><a href="#cb18-181"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-182"><a href="#cb18-182"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb18-183"><a href="#cb18-183"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"BBMISI"</span>),</span>
+<span id="cb18-184"><a href="#cb18-184"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(</span>
+<span id="cb18-185"><a href="#cb18-185"></a>      <span class="st">"Age (yr)"</span>,</span>
+<span id="cb18-186"><a href="#cb18-186"></a>      <span class="st">"Sex"</span>,</span>
+<span id="cb18-187"><a href="#cb18-187"></a>      <span class="st">"Race"</span>,</span>
+<span id="cb18-188"><a href="#cb18-188"></a>      <span class="st">"Baseline BMI"</span></span>
+<span id="cb18-189"><a href="#cb18-189"></a>    )</span>
+<span id="cb18-190"><a href="#cb18-190"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-191"><a href="#cb18-191"></a>  <span class="fu">build_table</span>(adsl)</span>
+<span id="cb18-192"><a href="#cb18-192"></a></span>
+<span id="cb18-193"><a href="#cb18-193"></a>result</span>
+<span id="cb18-194"><a href="#cb18-194"></a><span class="in">```</span></span>
+<span id="cb18-195"><a href="#cb18-195"></a></span>
+<span id="cb18-196"><a href="#cb18-196"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb18-197"><a href="#cb18-197"></a></span>
+<span id="cb18-198"><a href="#cb18-198"></a><span class="fu">## `teal` App</span></span>
+<span id="cb18-199"><a href="#cb18-199"></a></span>
+<span id="cb18-200"><a href="#cb18-200"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb18-201"><a href="#cb18-201"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb18-202"><a href="#cb18-202"></a></span>
+<span id="cb18-203"><a href="#cb18-203"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb18-204"><a href="#cb18-204"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-205"><a href="#cb18-205"></a></span>
+<span id="cb18-206"><a href="#cb18-206"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-207"><a href="#cb18-207"></a></span>
+<span id="cb18-208"><a href="#cb18-208"></a><span class="co"># Include `EOSDY` and `DCSREAS` variables below because they contain missing data.</span></span>
+<span id="cb18-209"><a href="#cb18-209"></a><span class="fu">stopifnot</span>(</span>
+<span id="cb18-210"><a href="#cb18-210"></a>  <span class="fu">any</span>(<span class="fu">is.na</span>(adsl<span class="sc">$</span>EOSDY)),</span>
+<span id="cb18-211"><a href="#cb18-211"></a>  <span class="fu">any</span>(<span class="fu">is.na</span>(adsl<span class="sc">$</span>DCSREAS))</span>
+<span id="cb18-212"><a href="#cb18-212"></a>)</span>
+<span id="cb18-213"><a href="#cb18-213"></a></span>
+<span id="cb18-214"><a href="#cb18-214"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb18-215"><a href="#cb18-215"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb18-216"><a href="#cb18-216"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb18-217"><a href="#cb18-217"></a>    <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>,</span>
+<span id="cb18-218"><a href="#cb18-218"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-219"><a href="#cb18-219"></a>  ),</span>
+<span id="cb18-220"><a href="#cb18-220"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb18-221"><a href="#cb18-221"></a>    <span class="fu">tm_t_summary</span>(</span>
+<span id="cb18-222"><a href="#cb18-222"></a>      <span class="at">label =</span> <span class="st">"Demographic Table"</span>,</span>
+<span id="cb18-223"><a href="#cb18-223"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb18-224"><a href="#cb18-224"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb18-225"><a href="#cb18-225"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-226"><a href="#cb18-226"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"BMRKR2"</span>, <span class="st">"EOSDY"</span>, <span class="st">"DCSREAS"</span>),</span>
+<span id="cb18-227"><a href="#cb18-227"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb18-228"><a href="#cb18-228"></a>      ),</span>
+<span id="cb18-229"><a href="#cb18-229"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span></span>
+<span id="cb18-230"><a href="#cb18-230"></a>    )</span>
+<span id="cb18-231"><a href="#cb18-231"></a>  )</span>
+<span id="cb18-232"><a href="#cb18-232"></a>)</span>
+<span id="cb18-233"><a href="#cb18-233"></a></span>
+<span id="cb18-234"><a href="#cb18-234"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb18-235"><a href="#cb18-235"></a><span class="in">```</span></span>
+<span id="cb18-236"><a href="#cb18-236"></a></span>
+<span id="cb18-237"><a href="#cb18-237"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb18-238"><a href="#cb18-238"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/disclosures/disclosurest01.html
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+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+<style>
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+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+.sourceCode { overflow: visible; }
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+  "copy-button": true,
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DISCLOSUREST01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Disclosures Outputs</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Patient Disposition Table <br> (CTgov &amp; EudraCT)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Demographic Table <br> (CTgov &amp; EudraCT)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Enrollment by Country <br> Table (EudraCT only)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Non-Serious Adverse Events <br> Reported in <span class="math inline">\(\geq\)</span> 5% of Patients in Any <br> Treatment Group (CTgov &amp; EudraCT)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Serious Adverse Events, Fatal SAEs <br> and SAEs Related to Study Medication, <br> by Treatment Group (CTgov &amp; EudraCT)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Death Table <br> (EudraCT only)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<section id="data-setup" class="level4"><h4 class="anchored" data-anchor-id="data-setup">Data Setup</h4>
+<div class="cell" data-hash="disclosurest01_cache/html/setup_b6fa55c5c29d3e5e55e8a460aee0fc0e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Add additional disposition variables to adsl.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adsl0 <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">STSTFL =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>      <span class="fu">is.na</span>(RANDDT) <span class="sc">~</span> <span class="st">"N"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Y"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">COMPSTUD =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="fu">c</span>(<span class="st">"Y"</span>, <span class="st">"N"</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">STUDONS =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="fu">c</span>(<span class="st">"Alive: On Treatment"</span>, <span class="st">"Alive: In Follow-up"</span>, <span class="cn">NA</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">STDDRS =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="fu">c</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>        <span class="st">"Death"</span>, <span class="st">"Lost To Follow-Up"</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>        <span class="st">"Protocol Violation"</span>, <span class="st">"Withdrawal By Subject"</span>,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>        <span class="st">"Other"</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>      ),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">GOTTRT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(ACTARMCD), <span class="st">"Y"</span>, <span class="st">"N"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>      <span class="fu">as.factor</span>(),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">DISTRTFL =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      <span class="fu">c</span>(<span class="st">"Y"</span>, <span class="st">"N"</span>),</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-43"><a href="#cb1-43"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">TRTDRS =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-46"><a href="#cb1-46"></a>      <span class="fu">c</span>(</span>
+<span id="cb1-47"><a href="#cb1-47"></a>        <span class="st">"ADVERSE EVENT"</span>, <span class="st">"PROGRESSIVE DISEASE"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>        <span class="st">"PHYSICIAN DECISION"</span>, <span class="st">"LACK OF EFFICACY"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>        <span class="st">"OTHER"</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>      ),</span>
+<span id="cb1-51"><a href="#cb1-51"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-52"><a href="#cb1-52"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    <span class="at">STUDONS =</span> <span class="fu">case_when</span>(COMPSTUD <span class="sc">==</span> <span class="st">"N"</span> <span class="sc">~</span> STUDONS),</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    <span class="at">STDDRS =</span> <span class="fu">case_when</span>(COMPSTUD <span class="sc">==</span> <span class="st">"N"</span> <span class="sc">&amp;</span> <span class="fu">is.na</span>(STUDONS) <span class="sc">~</span> STDDRS),</span>
+<span id="cb1-56"><a href="#cb1-56"></a>    <span class="at">DISSTDFL =</span> <span class="fu">case_when</span>(<span class="sc">!</span><span class="fu">is.na</span>(STDDRS) <span class="sc">~</span> <span class="st">"Y"</span>),</span>
+<span id="cb1-57"><a href="#cb1-57"></a>    <span class="at">DISTRTFL =</span> <span class="fu">case_when</span>(GOTTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> DISTRTFL),</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    <span class="at">TRTDRS =</span> <span class="fu">case_when</span>(DISTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> TRTDRS),</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="at">DRSCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-60"><a href="#cb1-60"></a>      TRTDRS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"PHYSICIAN DECISION"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>      <span class="sc">!</span><span class="fu">is.na</span>(TRTDRS) <span class="sc">~</span> <span class="st">"Other"</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a>    )</span>
+<span id="cb1-63"><a href="#cb1-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">STSTFL =</span> <span class="st">"Started Study"</span>,</span>
+<span id="cb1-66"><a href="#cb1-66"></a>    <span class="at">COMPSTUD =</span> <span class="st">"Complete Study"</span>,</span>
+<span id="cb1-67"><a href="#cb1-67"></a>    <span class="at">STUDONS =</span> <span class="st">"On-study Status"</span>,</span>
+<span id="cb1-68"><a href="#cb1-68"></a>    <span class="at">DISSTDFL =</span> <span class="st">"Discontinued Study"</span>,</span>
+<span id="cb1-69"><a href="#cb1-69"></a>    <span class="at">STDDRS =</span> <span class="st">"Reason for Study Discontinuation"</span>,</span>
+<span id="cb1-70"><a href="#cb1-70"></a>    <span class="at">GOTTRT =</span> <span class="st">"Received Treatment"</span>,</span>
+<span id="cb1-71"><a href="#cb1-71"></a>    <span class="at">DISTRTFL =</span> <span class="st">"Discontinued Treatment"</span>,</span>
+<span id="cb1-72"><a href="#cb1-72"></a>    <span class="at">TRTDRS =</span> <span class="st">"Reason for Treatment Discontinuation"</span>,</span>
+<span id="cb1-73"><a href="#cb1-73"></a>    <span class="at">DRSCAT =</span> <span class="st">"Subcategory for Treatment Discontinuation"</span></span>
+<span id="cb1-74"><a href="#cb1-74"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="patient-disposition-table" class="level4"><h4 class="anchored" data-anchor-id="patient-disposition-table">Patient Disposition Table</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant1_96ed1d5850fd8de7323d4212b79e1a25">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> <span class="fu">keep_split_levels</span>(<span class="st">"Y"</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"ARM"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">count_values</span>(<span class="st">"STSTFL"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Started Study"</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">count_values</span>(<span class="st">"COMPSTUD"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Completed Study"</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="st">"DISSTDFL"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">split_fun =</span> split_fun</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="fu">summarize_row_groups</span>(<span class="at">label_fstr =</span> <span class="st">"Discontinued Study"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="st">"STDDRS"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>  <span class="fu">append_topleft</span>(<span class="st">"Status"</span>)</span>
+<span id="cb2-27"><a href="#cb2-27"></a></span>
+<span id="cb2-28"><a href="#cb2-28"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl0)</span>
+<span id="cb2-29"><a href="#cb2-29"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Status                      A: Drug X      B: Placebo     C: Combination   All Patients 
+                             (N=134)         (N=134)         (N=132)          (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————
+Started Study             134 (100.00%)   134 (100.00%)   132 (100.00%)    400 (100.00%)
+Completed Study            65 (48.51%)     67 (50.00%)     69 (52.27%)     201 (50.25%) 
+Discontinued Study         15 (11.2%)      28 (20.9%)       24 (18.2%)      67 (16.8%)  
+  Death                      6 (40%)        5 (17.9%)       4 (16.7%)       15 (22.4%)  
+  Lost To Follow-Up         1 (6.7%)        3 (10.7%)       8 (33.3%)       12 (17.9%)  
+  Other                     2 (13.3%)       6 (21.4%)       5 (20.8%)       13 (19.4%)  
+  Protocol Violation        4 (26.7%)       4 (14.3%)       4 (16.7%)       12 (17.9%)  
+  Withdrawal By Subject     2 (13.3%)      10 (35.7%)       3 (12.5%)       15 (22.4%)  </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<section id="data-setup-1" class="level4"><h4 class="anchored" data-anchor-id="data-setup-1">Data Setup</h4>
+<div class="cell" data-hash="disclosurest01_cache/html/unnamed-chunk-1_e2469994cc7fc8a4cf348bd915877c67">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-9"><a href="#cb4-9"></a></span>
+<span id="cb4-10"><a href="#cb4-10"></a><span class="co"># Change description in variable SEX.</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>      SEX <span class="sc">==</span> <span class="st">"U"</span> <span class="sc">~</span> <span class="st">"Unknown"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>      SEX <span class="sc">==</span> <span class="st">"UNDIFFERENTIATED"</span> <span class="sc">~</span> <span class="st">"Undifferentiated"</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>    )),</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">AGEGRP =</span> <span class="fu">factor</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>        <span class="fu">between</span>(AGE, <span class="dv">18</span>, <span class="dv">40</span>) <span class="sc">~</span> <span class="st">"18-40"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>        <span class="fu">between</span>(AGE, <span class="dv">41</span>, <span class="dv">64</span>) <span class="sc">~</span> <span class="st">"41-64"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>        AGE <span class="sc">&gt;</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>      ),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"18-40"</span>, <span class="st">"41-64"</span>, <span class="st">"&gt;=65"</span>)</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    )</span>
+<span id="cb4-27"><a href="#cb4-27"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="demographic-table" class="level4"><h4 class="anchored" data-anchor-id="demographic-table">Demographic Table</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant2_a136035f72fd5bc1a1efa352af714498">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGRP"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"ETHNIC"</span>)</span>
+<span id="cb5-2"><a href="#cb5-2"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"Age (yr)"</span>, <span class="st">"Age group"</span>, <span class="st">"Sex"</span>, <span class="st">"Race"</span>, <span class="st">"Ethnicity"</span>)</span>
+<span id="cb5-3"><a href="#cb5-3"></a></span>
+<span id="cb5-4"><a href="#cb5-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb5-8"><a href="#cb5-8"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb5-10"><a href="#cb5-10"></a>  )</span>
+<span id="cb5-11"><a href="#cb5-11"></a></span>
+<span id="cb5-12"><a href="#cb5-12"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb5-13"><a href="#cb5-13"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                               A: Drug X    B: Placebo    C: Combination   All Patients
+                                                (N=134)       (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————————————————————————
+Age (yr)                                                                                               
+  n                                               134           134            132             400     
+  Mean (SD)                                   33.8 (6.6)    35.4 (7.9)      35.4 (7.7)      34.9 (7.4) 
+  Median                                         33.0          35.0            35.0            34.0    
+  Min - Max                                   21.0 - 50.0   21.0 - 62.0    20.0 - 69.0     20.0 - 69.0 
+Age group                                                                                              
+  n                                               134           134            132             400     
+  18-40                                       113 (84.3%)   103 (76.9%)    106 (80.3%)     322 (80.5%) 
+  41-64                                       21 (15.7%)    31 (23.1%)      25 (18.9%)      77 (19.2%) 
+  &gt;=65                                             0             0           1 (0.8%)        1 (0.2%)  
+Sex                                                                                                    
+  n                                               134           134            132             400     
+  Female                                       79 (59%)     82 (61.2%)       70 (53%)      231 (57.8%) 
+  Male                                         55 (41%)     52 (38.8%)       62 (47%)      169 (42.2%) 
+Race                                                                                                   
+  n                                               134           134            132             400     
+  ASIAN                                       68 (50.7%)     67 (50%)       73 (55.3%)      208 (52%)  
+  BLACK OR AFRICAN AMERICAN                   31 (23.1%)    28 (20.9%)      32 (24.2%)      91 (22.8%) 
+  WHITE                                       27 (20.1%)    26 (19.4%)      21 (15.9%)      74 (18.5%) 
+  AMERICAN INDIAN OR ALASKA NATIVE              8 (6%)       11 (8.2%)       6 (4.5%)       25 (6.2%)  
+  MULTIPLE                                         0         1 (0.7%)           0            1 (0.2%)  
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER        0         1 (0.7%)           0            1 (0.2%)  
+  OTHER                                            0             0              0               0      
+  UNKNOWN                                          0             0              0               0      
+Ethnicity                                                                                              
+  n                                               134           134            132             400     
+  NOT REPORTED                                 6 (4.5%)      10 (7.5%)      11 (8.3%)       27 (6.8%)  
+  HISPANIC OR LATINO                          15 (11.2%)    18 (13.4%)      15 (11.4%)       48 (12%)  
+  NOT HISPANIC OR LATINO                      104 (77.6%)   103 (76.9%)    101 (76.5%)      308 (77%)  
+  UNKNOWN                                      9 (6.7%)      3 (2.2%)        5 (3.8%)       17 (4.2%)  </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="data-setup-2" class="level4"><h4 class="anchored" data-anchor-id="data-setup-2">Data Setup</h4>
+<div class="cell" data-hash="disclosurest01_cache/html/unnamed-chunk-2_d40d2d434696548c8ed44d1bd8f4cba3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb7-2"><a href="#cb7-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb7-3"><a href="#cb7-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb7-4"><a href="#cb7-4"></a></span>
+<span id="cb7-5"><a href="#cb7-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb7-6"><a href="#cb7-6"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb7-9"><a href="#cb7-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb7-10"><a href="#cb7-10"></a></span>
+<span id="cb7-11"><a href="#cb7-11"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb7-12"><a href="#cb7-12"></a>  <span class="fu">mutate</span>(<span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb7-13"><a href="#cb7-13"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY)</span>
+<span id="cb7-14"><a href="#cb7-14"></a></span>
+<span id="cb7-15"><a href="#cb7-15"></a><span class="fu">var_labels</span>(adsl) <span class="ot">&lt;-</span> <span class="fu">c</span>(adsl_labels)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="enrollment-by-country-table" class="level4"><h4 class="anchored" data-anchor-id="enrollment-by-country-table">Enrollment by Country Table</h4>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant3_f4ec4d7c761de4df439e080e2303a9a4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">analyze_vars</span>(<span class="st">"COUNTRY"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"COUNTRY"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl)</span>
+<span id="cb8-8"><a href="#cb8-8"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Country   A: Drug X    B: Placebo   C: Combination   All Patients
+           (N=134)      (N=134)        (N=132)         (N=400)   
+—————————————————————————————————————————————————————————————————
+n            134          134            132             400     
+CHN       74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) 
+USA       10 (7.5%)    13 (9.7%)      17 (12.9%)       40 (10%)  
+BRA       13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+PAK        12 (9%)      9 (6.7%)      10 (7.6%)       31 (7.8%)  
+NGA         8 (6%)      7 (5.2%)      11 (8.3%)       26 (6.5%)  
+RUS        5 (3.7%)      8 (6%)        6 (4.5%)       19 (4.8%)  
+JPN        5 (3.7%)      4 (3%)        9 (6.8%)       18 (4.5%)  
+GBR         4 (3%)      3 (2.2%)       2 (1.5%)        9 (2.2%)  
+CAN        3 (2.2%)     2 (1.5%)       3 (2.3%)         8 (2%)   </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="data-setup-3" class="level4"><h4 class="anchored" data-anchor-id="data-setup-3">Data Setup</h4>
+<p>Trimming function <code>get_adae_trimmed</code> is defined to filter AEs with greater than 5% incidence rate.</p>
+<div class="cell" data-hash="disclosurest01_cache/html/unnamed-chunk-3_7d330ea158858d5f1ce247813343f597">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-9"><a href="#cb10-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-10"><a href="#cb10-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb10-11"><a href="#cb10-11"></a></span>
+<span id="cb10-12"><a href="#cb10-12"></a>adae_nonser <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">!=</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-13"><a href="#cb10-13"></a></span>
+<span id="cb10-14"><a href="#cb10-14"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb10-15"><a href="#cb10-15"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ARM)</span>
+<span id="cb10-17"><a href="#cb10-17"></a></span>
+<span id="cb10-18"><a href="#cb10-18"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb10-19"><a href="#cb10-19"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb10-20"><a href="#cb10-20"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb10-22"><a href="#cb10-22"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb10-25"><a href="#cb10-25"></a></span>
+<span id="cb10-26"><a href="#cb10-26"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    anl_terms,</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    n_per_arm,</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    <span class="at">by =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="fu">unique</span>()</span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb10-39"><a href="#cb10-39"></a>    anl_terms,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    adae,</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>  )</span>
+<span id="cb10-43"><a href="#cb10-43"></a>  anl</span>
+<span id="cb10-44"><a href="#cb10-44"></a>}</span>
+<span id="cb10-45"><a href="#cb10-45"></a></span>
+<span id="cb10-46"><a href="#cb10-46"></a>adae_trim <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae_nonser, <span class="at">cutoff_rate =</span> <span class="fl">0.05</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="non-serious-adverse-events-report-in-geq-5-of-patients-in-any-treatment-group" class="level4"><h4 class="anchored" data-anchor-id="non-serious-adverse-events-report-in-geq-5-of-patients-in-any-treatment-group">Non-Serious Adverse Events Report in <span class="math inline">\(\geq\)</span> 5% of Patients in Any Treatment Group</h4>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant4_876854143a2dbc8b348e74de776df34f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb11-3"><a href="#cb11-3"></a></span>
+<span id="cb11-4"><a href="#cb11-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-6"><a href="#cb11-6"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb11-7"><a href="#cb11-7"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5%"</span></span>
+<span id="cb11-8"><a href="#cb11-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb11-10"><a href="#cb11-10"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb11-11"><a href="#cb11-11"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb11-12"><a href="#cb11-12"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb11-13"><a href="#cb11-13"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-14"><a href="#cb11-14"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb11-15"><a href="#cb11-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-16"><a href="#cb11-16"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb11-17"><a href="#cb11-17"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb11-18"><a href="#cb11-18"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb11-19"><a href="#cb11-19"></a>  )</span>
+<span id="cb11-20"><a href="#cb11-20"></a></span>
+<span id="cb11-21"><a href="#cb11-21"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_trim)</span>
+<span id="cb11-22"><a href="#cb11-22"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                                                                A: Drug X                      B: Placebo                    C: Combination        
+  Dictionary-Derived Term                                                                                       Patients (All)   Events (All)   Patients (All)   Events (All)   Patients (All)   Events (All)
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5%        106             360             112             367             112             421     
+cl A.1                                                                                                                                                                                                       
+  dcd A.1.1.1.1                                                                                                       50              64              45              62              63              88     
+cl B.2                                                                                                                                                                                                       
+  dcd B.2.1.2.1                                                                                                       49              65              44              62              52              66     
+cl C.1                                                                                                                                                                                                       
+  dcd C.1.1.1.3                                                                                                       43              55              46              63              43              64     
+cl C.2                                                                                                                                                                                                       
+  dcd C.2.1.2.1                                                                                                       35              48              48              53              55              65     
+cl D.1                                                                                                                                                                                                       
+  dcd D.1.1.4.2                                                                                                       48              66              42              55              50              64     
+cl D.2                                                                                                                                                                                                       
+  dcd D.2.1.5.3                                                                                                       47              62              58              72              57              74     </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>For illustrative purposes, the <code>adae</code> data is filtered by arm “A: Drug X” here.</p>
+<section id="data-setup-4" class="level4"><h4 class="anchored" data-anchor-id="data-setup-4">Data Setup</h4>
+<div class="cell" data-hash="disclosurest01_cache/html/unnamed-chunk-4_c15200316e1262b9fd55a3aeed77f6bf">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb13-2"><a href="#cb13-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb13-3"><a href="#cb13-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb13-4"><a href="#cb13-4"></a></span>
+<span id="cb13-5"><a href="#cb13-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb13-6"><a href="#cb13-6"></a></span>
+<span id="cb13-7"><a href="#cb13-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb13-8"><a href="#cb13-8"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb13-9"><a href="#cb13-9"></a></span>
+<span id="cb13-10"><a href="#cb13-10"></a>adae_serious <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>adae_serious_arm <span class="ot">&lt;-</span> adae_serious <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb13-12"><a href="#cb13-12"></a></span>
+<span id="cb13-13"><a href="#cb13-13"></a>filters_list <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb13-14"><a href="#cb13-14"></a>  <span class="at">related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>), <span class="st">"Events (Related)"</span>),</span>
+<span id="cb13-15"><a href="#cb13-15"></a>  <span class="at">fatal =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal)"</span>),</span>
+<span id="cb13-16"><a href="#cb13-16"></a>  <span class="at">fatal_related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>, <span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal &amp; Related)"</span>)</span>
+<span id="cb13-17"><a href="#cb13-17"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="serious-adverse-events-fatal-saes-and-saes-related-to-study-medication-by-treatment-group" class="level4"><h4 class="anchored" data-anchor-id="serious-adverse-events-fatal-saes-and-saes-related-to-study-medication-by-treatment-group">Serious Adverse Events, Fatal SAEs and SAEs Related to Study Medication, by Treatment Group</h4>
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant5_e65e780e8b13ce143c9ff1d1ae7e6bf5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb14-3"><a href="#cb14-3"></a></span>
+<span id="cb14-4"><a href="#cb14-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb14-6"><a href="#cb14-6"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb14-7"><a href="#cb14-7"></a>    <span class="at">empty_stats =</span> <span class="fu">c</span>(<span class="st">"all"</span>, <span class="st">"related"</span>, <span class="st">"fatal"</span>, <span class="st">"fatal_related"</span>),</span>
+<span id="cb14-8"><a href="#cb14-8"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one serious adverse event"</span></span>
+<span id="cb14-9"><a href="#cb14-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-10"><a href="#cb14-10"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb14-11"><a href="#cb14-11"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb14-12"><a href="#cb14-12"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb14-13"><a href="#cb14-13"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb14-14"><a href="#cb14-14"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb14-15"><a href="#cb14-15"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb14-16"><a href="#cb14-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-17"><a href="#cb14-17"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>,</span>
+<span id="cb14-18"><a href="#cb14-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb14-19"><a href="#cb14-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb14-20"><a href="#cb14-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEDECOD)</span>
+<span id="cb14-21"><a href="#cb14-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-22"><a href="#cb14-22"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb14-23"><a href="#cb14-23"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb14-24"><a href="#cb14-24"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a>  )</span>
+<span id="cb14-26"><a href="#cb14-26"></a></span>
+<span id="cb14-27"><a href="#cb14-27"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_serious_arm)</span>
+<span id="cb14-28"><a href="#cb14-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                                                                                                     
+  Dictionary-Derived Term                                          Patients (All)   Events (All)   Events (Related)   Events (Fatal)   Events (Fatal &amp; Related)
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one serious adverse event        104                                                                                    
+cl A.1                                                                                                                                                         
+  dcd A.1.1.1.2                                                          48              68               0                 0                     0            
+cl B.1                                                                                                                                                         
+  dcd B.1.1.1.1                                                          47              56               56                56                    56           
+cl B.2                                                                                                                                                         
+  dcd B.2.2.3.1                                                          48              64               0                 0                     0            
+cl D.1                                                                                                                                                         
+  dcd D.1.1.1.1                                                          50              61               61                61                    61           </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="data-setup-5" class="level4"><h4 class="anchored" data-anchor-id="data-setup-5">Data Setup</h4>
+<div class="cell" data-hash="disclosurest01_cache/html/unnamed-chunk-5_287cda61ee3bc76da8431a2cd314dc4e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-4"><a href="#cb16-4"></a></span>
+<span id="cb16-5"><a href="#cb16-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-6"><a href="#cb16-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section><section id="death-table" class="level4"><h4 class="anchored" data-anchor-id="death-table">Death Table</h4>
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="disclosurest01_cache/html/variant6_8ab8729b82a5467523e94d598b9aa97f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb17-2"><a href="#cb17-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb17-3"><a href="#cb17-3"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb17-4"><a href="#cb17-4"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb17-5"><a href="#cb17-5"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb17-6"><a href="#cb17-6"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"AESDTH"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb17-7"><a href="#cb17-7"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total Number of Deaths"</span>),</span>
+<span id="cb17-8"><a href="#cb17-8"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.xx%)"</span>)</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  )</span>
+<span id="cb17-10"><a href="#cb17-10"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                          A: Drug X    B: Placebo    C: Combination   All Patients
+                           (N=134)       (N=134)        (N=132)         (N=400)   
+——————————————————————————————————————————————————————————————————————————————————
+Total Number of Deaths   76 (62.30%)   70 (56.91%)    75 (62.50%)     221 (60.55%)</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="disclosurest01_cache/html/sessioninfo_41dc7f5941de18d6cc88ec43aeac87bb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb19"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb19-1"><a href="#cb19-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       
+[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  
+[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="disclosurest01_cache/html/snapshot_ab493c449296d9e9a1cf91a08dfce2d2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb21"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb21-1"><a href="#cb21-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb21-2"><a href="#cb21-2"></a></span>
+<span id="cb21-3"><a href="#cb21-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb21-4"><a href="#cb21-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb21-5"><a href="#cb21-5"></a></span>
+<span id="cb21-6"><a href="#cb21-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb21-7"><a href="#cb21-7"></a></span>
+<span id="cb21-8"><a href="#cb21-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb21-9"><a href="#cb21-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb21-10"><a href="#cb21-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb21-11"><a href="#cb21-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disclosures/disclosurest01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
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+      return codeEl.innerText;
+    }
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+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
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+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
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+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
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+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+          }
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
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+              div.setAttribute("id", "code-annotation-line-highlight");
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+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+      });
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+  }
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb22" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb22-1"><a href="#cb22-1"></a><span class="co">---</span></span>
+<span id="cb22-2"><a href="#cb22-2"></a><span class="an">title:</span><span class="co"> DISCLOSUREST01</span></span>
+<span id="cb22-3"><a href="#cb22-3"></a><span class="an">subtitle:</span><span class="co"> Disclosures Outputs</span></span>
+<span id="cb22-4"><a href="#cb22-4"></a><span class="co">---</span></span>
+<span id="cb22-5"><a href="#cb22-5"></a></span>
+<span id="cb22-6"><a href="#cb22-6"></a>------------------------------------------------------------------------</span>
+<span id="cb22-7"><a href="#cb22-7"></a></span>
+<span id="cb22-8"><a href="#cb22-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb22-9"><a href="#cb22-9"></a></span>
+<span id="cb22-10"><a href="#cb22-10"></a>::: panel-tabset</span>
+<span id="cb22-11"><a href="#cb22-11"></a><span class="fu">## Patient Disposition Table &lt;br/&gt; (CTgov &amp; EudraCT)</span></span>
+<span id="cb22-12"><a href="#cb22-12"></a></span>
+<span id="cb22-13"><a href="#cb22-13"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-14"><a href="#cb22-14"></a></span>
+<span id="cb22-15"><a href="#cb22-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb22-16"><a href="#cb22-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-17"><a href="#cb22-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-18"><a href="#cb22-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-19"><a href="#cb22-19"></a></span>
+<span id="cb22-20"><a href="#cb22-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-21"><a href="#cb22-21"></a></span>
+<span id="cb22-22"><a href="#cb22-22"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb22-23"><a href="#cb22-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb22-24"><a href="#cb22-24"></a></span>
+<span id="cb22-25"><a href="#cb22-25"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb22-26"><a href="#cb22-26"></a></span>
+<span id="cb22-27"><a href="#cb22-27"></a><span class="co"># Add additional disposition variables to adsl.</span></span>
+<span id="cb22-28"><a href="#cb22-28"></a>adsl0 <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb22-29"><a href="#cb22-29"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb22-30"><a href="#cb22-30"></a>    <span class="at">STSTFL =</span> <span class="fu">case_when</span>(</span>
+<span id="cb22-31"><a href="#cb22-31"></a>      <span class="fu">is.na</span>(RANDDT) <span class="sc">~</span> <span class="st">"N"</span>,</span>
+<span id="cb22-32"><a href="#cb22-32"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Y"</span></span>
+<span id="cb22-33"><a href="#cb22-33"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-34"><a href="#cb22-34"></a>    <span class="at">COMPSTUD =</span> <span class="fu">sample</span>(</span>
+<span id="cb22-35"><a href="#cb22-35"></a>      <span class="fu">c</span>(<span class="st">"Y"</span>, <span class="st">"N"</span>),</span>
+<span id="cb22-36"><a href="#cb22-36"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb22-37"><a href="#cb22-37"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-38"><a href="#cb22-38"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-39"><a href="#cb22-39"></a>    <span class="at">STUDONS =</span> <span class="fu">sample</span>(</span>
+<span id="cb22-40"><a href="#cb22-40"></a>      <span class="fu">c</span>(<span class="st">"Alive: On Treatment"</span>, <span class="st">"Alive: In Follow-up"</span>, <span class="cn">NA</span>),</span>
+<span id="cb22-41"><a href="#cb22-41"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb22-42"><a href="#cb22-42"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-43"><a href="#cb22-43"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-44"><a href="#cb22-44"></a>    <span class="at">STDDRS =</span> <span class="fu">sample</span>(</span>
+<span id="cb22-45"><a href="#cb22-45"></a>      <span class="fu">c</span>(</span>
+<span id="cb22-46"><a href="#cb22-46"></a>        <span class="st">"Death"</span>, <span class="st">"Lost To Follow-Up"</span>,</span>
+<span id="cb22-47"><a href="#cb22-47"></a>        <span class="st">"Protocol Violation"</span>, <span class="st">"Withdrawal By Subject"</span>,</span>
+<span id="cb22-48"><a href="#cb22-48"></a>        <span class="st">"Other"</span></span>
+<span id="cb22-49"><a href="#cb22-49"></a>      ),</span>
+<span id="cb22-50"><a href="#cb22-50"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb22-51"><a href="#cb22-51"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-52"><a href="#cb22-52"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-53"><a href="#cb22-53"></a>    <span class="at">GOTTRT =</span> <span class="fu">ifelse</span>(<span class="sc">!</span><span class="fu">is.na</span>(ACTARMCD), <span class="st">"Y"</span>, <span class="st">"N"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-54"><a href="#cb22-54"></a>      <span class="fu">as.factor</span>(),</span>
+<span id="cb22-55"><a href="#cb22-55"></a>    <span class="at">DISTRTFL =</span> <span class="fu">sample</span>(</span>
+<span id="cb22-56"><a href="#cb22-56"></a>      <span class="fu">c</span>(<span class="st">"Y"</span>, <span class="st">"N"</span>),</span>
+<span id="cb22-57"><a href="#cb22-57"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb22-58"><a href="#cb22-58"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-59"><a href="#cb22-59"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-60"><a href="#cb22-60"></a>    <span class="at">TRTDRS =</span> <span class="fu">sample</span>(</span>
+<span id="cb22-61"><a href="#cb22-61"></a>      <span class="fu">c</span>(</span>
+<span id="cb22-62"><a href="#cb22-62"></a>        <span class="st">"ADVERSE EVENT"</span>, <span class="st">"PROGRESSIVE DISEASE"</span>,</span>
+<span id="cb22-63"><a href="#cb22-63"></a>        <span class="st">"PHYSICIAN DECISION"</span>, <span class="st">"LACK OF EFFICACY"</span>,</span>
+<span id="cb22-64"><a href="#cb22-64"></a>        <span class="st">"OTHER"</span></span>
+<span id="cb22-65"><a href="#cb22-65"></a>      ),</span>
+<span id="cb22-66"><a href="#cb22-66"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb22-67"><a href="#cb22-67"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-68"><a href="#cb22-68"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb22-69"><a href="#cb22-69"></a>    <span class="at">STUDONS =</span> <span class="fu">case_when</span>(COMPSTUD <span class="sc">==</span> <span class="st">"N"</span> <span class="sc">~</span> STUDONS),</span>
+<span id="cb22-70"><a href="#cb22-70"></a>    <span class="at">STDDRS =</span> <span class="fu">case_when</span>(COMPSTUD <span class="sc">==</span> <span class="st">"N"</span> <span class="sc">&amp;</span> <span class="fu">is.na</span>(STUDONS) <span class="sc">~</span> STDDRS),</span>
+<span id="cb22-71"><a href="#cb22-71"></a>    <span class="at">DISSTDFL =</span> <span class="fu">case_when</span>(<span class="sc">!</span><span class="fu">is.na</span>(STDDRS) <span class="sc">~</span> <span class="st">"Y"</span>),</span>
+<span id="cb22-72"><a href="#cb22-72"></a>    <span class="at">DISTRTFL =</span> <span class="fu">case_when</span>(GOTTRT <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> DISTRTFL),</span>
+<span id="cb22-73"><a href="#cb22-73"></a>    <span class="at">TRTDRS =</span> <span class="fu">case_when</span>(DISTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> TRTDRS),</span>
+<span id="cb22-74"><a href="#cb22-74"></a>    <span class="at">DRSCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb22-75"><a href="#cb22-75"></a>      TRTDRS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"PHYSICIAN DECISION"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb22-76"><a href="#cb22-76"></a>      <span class="sc">!</span><span class="fu">is.na</span>(TRTDRS) <span class="sc">~</span> <span class="st">"Other"</span></span>
+<span id="cb22-77"><a href="#cb22-77"></a>    )</span>
+<span id="cb22-78"><a href="#cb22-78"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-79"><a href="#cb22-79"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb22-80"><a href="#cb22-80"></a>    <span class="at">STSTFL =</span> <span class="st">"Started Study"</span>,</span>
+<span id="cb22-81"><a href="#cb22-81"></a>    <span class="at">COMPSTUD =</span> <span class="st">"Complete Study"</span>,</span>
+<span id="cb22-82"><a href="#cb22-82"></a>    <span class="at">STUDONS =</span> <span class="st">"On-study Status"</span>,</span>
+<span id="cb22-83"><a href="#cb22-83"></a>    <span class="at">DISSTDFL =</span> <span class="st">"Discontinued Study"</span>,</span>
+<span id="cb22-84"><a href="#cb22-84"></a>    <span class="at">STDDRS =</span> <span class="st">"Reason for Study Discontinuation"</span>,</span>
+<span id="cb22-85"><a href="#cb22-85"></a>    <span class="at">GOTTRT =</span> <span class="st">"Received Treatment"</span>,</span>
+<span id="cb22-86"><a href="#cb22-86"></a>    <span class="at">DISTRTFL =</span> <span class="st">"Discontinued Treatment"</span>,</span>
+<span id="cb22-87"><a href="#cb22-87"></a>    <span class="at">TRTDRS =</span> <span class="st">"Reason for Treatment Discontinuation"</span>,</span>
+<span id="cb22-88"><a href="#cb22-88"></a>    <span class="at">DRSCAT =</span> <span class="st">"Subcategory for Treatment Discontinuation"</span></span>
+<span id="cb22-89"><a href="#cb22-89"></a>  )</span>
+<span id="cb22-90"><a href="#cb22-90"></a><span class="in">```</span></span>
+<span id="cb22-91"><a href="#cb22-91"></a></span>
+<span id="cb22-92"><a href="#cb22-92"></a><span class="fu">#### Patient Disposition Table</span></span>
+<span id="cb22-93"><a href="#cb22-93"></a></span>
+<span id="cb22-94"><a href="#cb22-94"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb22-95"><a href="#cb22-95"></a><span class="co"># Define the split function</span></span>
+<span id="cb22-96"><a href="#cb22-96"></a>split_fun <span class="ot">&lt;-</span> <span class="fu">keep_split_levels</span>(<span class="st">"Y"</span>)</span>
+<span id="cb22-97"><a href="#cb22-97"></a></span>
+<span id="cb22-98"><a href="#cb22-98"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-99"><a href="#cb22-99"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb22-100"><a href="#cb22-100"></a>    <span class="st">"ARM"</span>,</span>
+<span id="cb22-101"><a href="#cb22-101"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb22-102"><a href="#cb22-102"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-103"><a href="#cb22-103"></a>  <span class="fu">count_values</span>(<span class="st">"STSTFL"</span>,</span>
+<span id="cb22-104"><a href="#cb22-104"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb22-105"><a href="#cb22-105"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Started Study"</span>)</span>
+<span id="cb22-106"><a href="#cb22-106"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-107"><a href="#cb22-107"></a>  <span class="fu">count_values</span>(<span class="st">"COMPSTUD"</span>,</span>
+<span id="cb22-108"><a href="#cb22-108"></a>    <span class="at">values =</span> <span class="st">"Y"</span>,</span>
+<span id="cb22-109"><a href="#cb22-109"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Completed Study"</span>)</span>
+<span id="cb22-110"><a href="#cb22-110"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-111"><a href="#cb22-111"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb22-112"><a href="#cb22-112"></a>    <span class="st">"DISSTDFL"</span>,</span>
+<span id="cb22-113"><a href="#cb22-113"></a>    <span class="at">split_fun =</span> split_fun</span>
+<span id="cb22-114"><a href="#cb22-114"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-115"><a href="#cb22-115"></a>  <span class="fu">summarize_row_groups</span>(<span class="at">label_fstr =</span> <span class="st">"Discontinued Study"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-116"><a href="#cb22-116"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb22-117"><a href="#cb22-117"></a>    <span class="st">"STDDRS"</span>,</span>
+<span id="cb22-118"><a href="#cb22-118"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span></span>
+<span id="cb22-119"><a href="#cb22-119"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-120"><a href="#cb22-120"></a>  <span class="fu">append_topleft</span>(<span class="st">"Status"</span>)</span>
+<span id="cb22-121"><a href="#cb22-121"></a></span>
+<span id="cb22-122"><a href="#cb22-122"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl0)</span>
+<span id="cb22-123"><a href="#cb22-123"></a>result</span>
+<span id="cb22-124"><a href="#cb22-124"></a><span class="in">```</span></span>
+<span id="cb22-125"><a href="#cb22-125"></a></span>
+<span id="cb22-126"><a href="#cb22-126"></a><span class="fu">## Demographic Table &lt;br/&gt; (CTgov &amp; EudraCT)</span></span>
+<span id="cb22-127"><a href="#cb22-127"></a></span>
+<span id="cb22-128"><a href="#cb22-128"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-129"><a href="#cb22-129"></a></span>
+<span id="cb22-132"><a href="#cb22-132"></a><span class="in">```{r}</span></span>
+<span id="cb22-133"><a href="#cb22-133"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-134"><a href="#cb22-134"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-135"><a href="#cb22-135"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-136"><a href="#cb22-136"></a></span>
+<span id="cb22-137"><a href="#cb22-137"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-138"><a href="#cb22-138"></a></span>
+<span id="cb22-139"><a href="#cb22-139"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb22-140"><a href="#cb22-140"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb22-141"><a href="#cb22-141"></a></span>
+<span id="cb22-142"><a href="#cb22-142"></a><span class="co"># Change description in variable SEX.</span></span>
+<span id="cb22-143"><a href="#cb22-143"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb22-144"><a href="#cb22-144"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb22-145"><a href="#cb22-145"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb22-146"><a href="#cb22-146"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span>,</span>
+<span id="cb22-147"><a href="#cb22-147"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb22-148"><a href="#cb22-148"></a>      SEX <span class="sc">==</span> <span class="st">"U"</span> <span class="sc">~</span> <span class="st">"Unknown"</span>,</span>
+<span id="cb22-149"><a href="#cb22-149"></a>      SEX <span class="sc">==</span> <span class="st">"UNDIFFERENTIATED"</span> <span class="sc">~</span> <span class="st">"Undifferentiated"</span></span>
+<span id="cb22-150"><a href="#cb22-150"></a>    )),</span>
+<span id="cb22-151"><a href="#cb22-151"></a>    <span class="at">AGEGRP =</span> <span class="fu">factor</span>(</span>
+<span id="cb22-152"><a href="#cb22-152"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb22-153"><a href="#cb22-153"></a>        <span class="fu">between</span>(AGE, <span class="dv">18</span>, <span class="dv">40</span>) <span class="sc">~</span> <span class="st">"18-40"</span>,</span>
+<span id="cb22-154"><a href="#cb22-154"></a>        <span class="fu">between</span>(AGE, <span class="dv">41</span>, <span class="dv">64</span>) <span class="sc">~</span> <span class="st">"41-64"</span>,</span>
+<span id="cb22-155"><a href="#cb22-155"></a>        AGE <span class="sc">&gt;</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb22-156"><a href="#cb22-156"></a>      ),</span>
+<span id="cb22-157"><a href="#cb22-157"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"18-40"</span>, <span class="st">"41-64"</span>, <span class="st">"&gt;=65"</span>)</span>
+<span id="cb22-158"><a href="#cb22-158"></a>    )</span>
+<span id="cb22-159"><a href="#cb22-159"></a>  )</span>
+<span id="cb22-160"><a href="#cb22-160"></a><span class="in">```</span></span>
+<span id="cb22-161"><a href="#cb22-161"></a></span>
+<span id="cb22-162"><a href="#cb22-162"></a><span class="fu">#### Demographic Table</span></span>
+<span id="cb22-163"><a href="#cb22-163"></a></span>
+<span id="cb22-164"><a href="#cb22-164"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb22-165"><a href="#cb22-165"></a>vars <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"AGEGRP"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>, <span class="st">"ETHNIC"</span>)</span>
+<span id="cb22-166"><a href="#cb22-166"></a>var_labels <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"Age (yr)"</span>, <span class="st">"Age group"</span>, <span class="st">"Sex"</span>, <span class="st">"Race"</span>, <span class="st">"Ethnicity"</span>)</span>
+<span id="cb22-167"><a href="#cb22-167"></a></span>
+<span id="cb22-168"><a href="#cb22-168"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-169"><a href="#cb22-169"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-170"><a href="#cb22-170"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-171"><a href="#cb22-171"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb22-172"><a href="#cb22-172"></a>    <span class="at">vars =</span> vars,</span>
+<span id="cb22-173"><a href="#cb22-173"></a>    <span class="at">var_labels =</span> var_labels</span>
+<span id="cb22-174"><a href="#cb22-174"></a>  )</span>
+<span id="cb22-175"><a href="#cb22-175"></a></span>
+<span id="cb22-176"><a href="#cb22-176"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb22-177"><a href="#cb22-177"></a>result</span>
+<span id="cb22-178"><a href="#cb22-178"></a><span class="in">```</span></span>
+<span id="cb22-179"><a href="#cb22-179"></a></span>
+<span id="cb22-180"><a href="#cb22-180"></a><span class="fu">## Enrollment by Country &lt;br/&gt; Table (EudraCT only)</span></span>
+<span id="cb22-181"><a href="#cb22-181"></a></span>
+<span id="cb22-182"><a href="#cb22-182"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-183"><a href="#cb22-183"></a></span>
+<span id="cb22-186"><a href="#cb22-186"></a><span class="in">```{r}</span></span>
+<span id="cb22-187"><a href="#cb22-187"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-188"><a href="#cb22-188"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-189"><a href="#cb22-189"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-190"><a href="#cb22-190"></a></span>
+<span id="cb22-191"><a href="#cb22-191"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-192"><a href="#cb22-192"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb22-193"><a href="#cb22-193"></a></span>
+<span id="cb22-194"><a href="#cb22-194"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb22-195"><a href="#cb22-195"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb22-196"><a href="#cb22-196"></a></span>
+<span id="cb22-197"><a href="#cb22-197"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb22-198"><a href="#cb22-198"></a>  <span class="fu">mutate</span>(<span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb22-199"><a href="#cb22-199"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY)</span>
+<span id="cb22-200"><a href="#cb22-200"></a></span>
+<span id="cb22-201"><a href="#cb22-201"></a><span class="fu">var_labels</span>(adsl) <span class="ot">&lt;-</span> <span class="fu">c</span>(adsl_labels)</span>
+<span id="cb22-202"><a href="#cb22-202"></a><span class="in">```</span></span>
+<span id="cb22-203"><a href="#cb22-203"></a></span>
+<span id="cb22-204"><a href="#cb22-204"></a><span class="fu">#### Enrollment by Country Table</span></span>
+<span id="cb22-205"><a href="#cb22-205"></a></span>
+<span id="cb22-206"><a href="#cb22-206"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb22-207"><a href="#cb22-207"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-208"><a href="#cb22-208"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-209"><a href="#cb22-209"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-210"><a href="#cb22-210"></a>  <span class="fu">analyze_vars</span>(<span class="st">"COUNTRY"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-211"><a href="#cb22-211"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"COUNTRY"</span>)</span>
+<span id="cb22-212"><a href="#cb22-212"></a></span>
+<span id="cb22-213"><a href="#cb22-213"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl)</span>
+<span id="cb22-214"><a href="#cb22-214"></a>result</span>
+<span id="cb22-215"><a href="#cb22-215"></a><span class="in">```</span></span>
+<span id="cb22-216"><a href="#cb22-216"></a></span>
+<span id="cb22-217"><a href="#cb22-217"></a><span class="fu">## Non-Serious Adverse Events &lt;br/&gt; Reported in $\geq$ 5% of Patients in Any &lt;br/&gt; Treatment Group (CTgov &amp; EudraCT)</span></span>
+<span id="cb22-218"><a href="#cb22-218"></a></span>
+<span id="cb22-219"><a href="#cb22-219"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-220"><a href="#cb22-220"></a></span>
+<span id="cb22-221"><a href="#cb22-221"></a>Trimming function <span class="in">`get_adae_trimmed`</span> is defined to filter AEs with greater than 5% incidence rate.</span>
+<span id="cb22-222"><a href="#cb22-222"></a></span>
+<span id="cb22-225"><a href="#cb22-225"></a><span class="in">```{r}</span></span>
+<span id="cb22-226"><a href="#cb22-226"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-227"><a href="#cb22-227"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-228"><a href="#cb22-228"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-229"><a href="#cb22-229"></a></span>
+<span id="cb22-230"><a href="#cb22-230"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-231"><a href="#cb22-231"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb22-232"><a href="#cb22-232"></a></span>
+<span id="cb22-233"><a href="#cb22-233"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb22-234"><a href="#cb22-234"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb22-235"><a href="#cb22-235"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb22-236"><a href="#cb22-236"></a></span>
+<span id="cb22-237"><a href="#cb22-237"></a>adae_nonser <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">!=</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb22-238"><a href="#cb22-238"></a></span>
+<span id="cb22-239"><a href="#cb22-239"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb22-240"><a href="#cb22-240"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb22-241"><a href="#cb22-241"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ARM)</span>
+<span id="cb22-242"><a href="#cb22-242"></a></span>
+<span id="cb22-243"><a href="#cb22-243"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb22-244"><a href="#cb22-244"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb22-245"><a href="#cb22-245"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb22-246"><a href="#cb22-246"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb22-247"><a href="#cb22-247"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-248"><a href="#cb22-248"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb22-249"><a href="#cb22-249"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb22-250"><a href="#cb22-250"></a></span>
+<span id="cb22-251"><a href="#cb22-251"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb22-252"><a href="#cb22-252"></a>    anl_terms,</span>
+<span id="cb22-253"><a href="#cb22-253"></a>    n_per_arm,</span>
+<span id="cb22-254"><a href="#cb22-254"></a>    <span class="at">by =</span> <span class="st">"ARM"</span></span>
+<span id="cb22-255"><a href="#cb22-255"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-256"><a href="#cb22-256"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb22-257"><a href="#cb22-257"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb22-258"><a href="#cb22-258"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-259"><a href="#cb22-259"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb22-260"><a href="#cb22-260"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb22-261"><a href="#cb22-261"></a>    <span class="fu">unique</span>()</span>
+<span id="cb22-262"><a href="#cb22-262"></a></span>
+<span id="cb22-263"><a href="#cb22-263"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb22-264"><a href="#cb22-264"></a>    anl_terms,</span>
+<span id="cb22-265"><a href="#cb22-265"></a>    adae,</span>
+<span id="cb22-266"><a href="#cb22-266"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb22-267"><a href="#cb22-267"></a>  )</span>
+<span id="cb22-268"><a href="#cb22-268"></a>  anl</span>
+<span id="cb22-269"><a href="#cb22-269"></a>}</span>
+<span id="cb22-270"><a href="#cb22-270"></a></span>
+<span id="cb22-271"><a href="#cb22-271"></a>adae_trim <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae_nonser, <span class="at">cutoff_rate =</span> <span class="fl">0.05</span>)</span>
+<span id="cb22-272"><a href="#cb22-272"></a><span class="in">```</span></span>
+<span id="cb22-273"><a href="#cb22-273"></a></span>
+<span id="cb22-274"><a href="#cb22-274"></a><span class="fu">#### Non-Serious Adverse Events Report in $\geq$ 5% of Patients in Any Treatment Group</span></span>
+<span id="cb22-275"><a href="#cb22-275"></a></span>
+<span id="cb22-276"><a href="#cb22-276"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb22-277"><a href="#cb22-277"></a><span class="co"># Define the split function</span></span>
+<span id="cb22-278"><a href="#cb22-278"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb22-279"><a href="#cb22-279"></a></span>
+<span id="cb22-280"><a href="#cb22-280"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb22-281"><a href="#cb22-281"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-282"><a href="#cb22-282"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb22-283"><a href="#cb22-283"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5%"</span></span>
+<span id="cb22-284"><a href="#cb22-284"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-285"><a href="#cb22-285"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb22-286"><a href="#cb22-286"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb22-287"><a href="#cb22-287"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb22-288"><a href="#cb22-288"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb22-289"><a href="#cb22-289"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb22-290"><a href="#cb22-290"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb22-291"><a href="#cb22-291"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-292"><a href="#cb22-292"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb22-293"><a href="#cb22-293"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb22-294"><a href="#cb22-294"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb22-295"><a href="#cb22-295"></a>  )</span>
+<span id="cb22-296"><a href="#cb22-296"></a></span>
+<span id="cb22-297"><a href="#cb22-297"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_trim)</span>
+<span id="cb22-298"><a href="#cb22-298"></a>result</span>
+<span id="cb22-299"><a href="#cb22-299"></a><span class="in">```</span></span>
+<span id="cb22-300"><a href="#cb22-300"></a></span>
+<span id="cb22-301"><a href="#cb22-301"></a><span class="fu">## Serious Adverse Events, Fatal SAEs &lt;br/&gt; and SAEs Related to Study Medication, &lt;br/&gt; by Treatment Group (CTgov &amp; EudraCT)</span></span>
+<span id="cb22-302"><a href="#cb22-302"></a></span>
+<span id="cb22-303"><a href="#cb22-303"></a>For illustrative purposes, the <span class="in">`adae`</span> data is filtered by arm "A: Drug X" here.</span>
+<span id="cb22-304"><a href="#cb22-304"></a></span>
+<span id="cb22-305"><a href="#cb22-305"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-306"><a href="#cb22-306"></a></span>
+<span id="cb22-309"><a href="#cb22-309"></a><span class="in">```{r}</span></span>
+<span id="cb22-310"><a href="#cb22-310"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-311"><a href="#cb22-311"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-312"><a href="#cb22-312"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-313"><a href="#cb22-313"></a></span>
+<span id="cb22-314"><a href="#cb22-314"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb22-315"><a href="#cb22-315"></a></span>
+<span id="cb22-316"><a href="#cb22-316"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb22-317"><a href="#cb22-317"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb22-318"><a href="#cb22-318"></a></span>
+<span id="cb22-319"><a href="#cb22-319"></a>adae_serious <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb22-320"><a href="#cb22-320"></a>adae_serious_arm <span class="ot">&lt;-</span> adae_serious <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb22-321"><a href="#cb22-321"></a></span>
+<span id="cb22-322"><a href="#cb22-322"></a>filters_list <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb22-323"><a href="#cb22-323"></a>  <span class="at">related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>), <span class="st">"Events (Related)"</span>),</span>
+<span id="cb22-324"><a href="#cb22-324"></a>  <span class="at">fatal =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal)"</span>),</span>
+<span id="cb22-325"><a href="#cb22-325"></a>  <span class="at">fatal_related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>, <span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal &amp; Related)"</span>)</span>
+<span id="cb22-326"><a href="#cb22-326"></a>)</span>
+<span id="cb22-327"><a href="#cb22-327"></a><span class="in">```</span></span>
+<span id="cb22-328"><a href="#cb22-328"></a></span>
+<span id="cb22-329"><a href="#cb22-329"></a><span class="fu">#### Serious Adverse Events, Fatal SAEs and SAEs Related to Study Medication, by Treatment Group</span></span>
+<span id="cb22-330"><a href="#cb22-330"></a></span>
+<span id="cb22-331"><a href="#cb22-331"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb22-332"><a href="#cb22-332"></a><span class="co"># Define the split function</span></span>
+<span id="cb22-333"><a href="#cb22-333"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb22-334"><a href="#cb22-334"></a></span>
+<span id="cb22-335"><a href="#cb22-335"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb22-336"><a href="#cb22-336"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb22-337"><a href="#cb22-337"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb22-338"><a href="#cb22-338"></a>    <span class="at">empty_stats =</span> <span class="fu">c</span>(<span class="st">"all"</span>, <span class="st">"related"</span>, <span class="st">"fatal"</span>, <span class="st">"fatal_related"</span>),</span>
+<span id="cb22-339"><a href="#cb22-339"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one serious adverse event"</span></span>
+<span id="cb22-340"><a href="#cb22-340"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-341"><a href="#cb22-341"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb22-342"><a href="#cb22-342"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb22-343"><a href="#cb22-343"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb22-344"><a href="#cb22-344"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb22-345"><a href="#cb22-345"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb22-346"><a href="#cb22-346"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb22-347"><a href="#cb22-347"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-348"><a href="#cb22-348"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>,</span>
+<span id="cb22-349"><a href="#cb22-349"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb22-350"><a href="#cb22-350"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb22-351"><a href="#cb22-351"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEDECOD)</span>
+<span id="cb22-352"><a href="#cb22-352"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb22-353"><a href="#cb22-353"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb22-354"><a href="#cb22-354"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb22-355"><a href="#cb22-355"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb22-356"><a href="#cb22-356"></a>  )</span>
+<span id="cb22-357"><a href="#cb22-357"></a></span>
+<span id="cb22-358"><a href="#cb22-358"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_serious_arm)</span>
+<span id="cb22-359"><a href="#cb22-359"></a>result</span>
+<span id="cb22-360"><a href="#cb22-360"></a><span class="in">```</span></span>
+<span id="cb22-361"><a href="#cb22-361"></a></span>
+<span id="cb22-362"><a href="#cb22-362"></a><span class="fu">## Death Table &lt;br/&gt; (EudraCT only)</span></span>
+<span id="cb22-363"><a href="#cb22-363"></a></span>
+<span id="cb22-364"><a href="#cb22-364"></a><span class="fu">#### Data Setup</span></span>
+<span id="cb22-365"><a href="#cb22-365"></a></span>
+<span id="cb22-368"><a href="#cb22-368"></a><span class="in">```{r}</span></span>
+<span id="cb22-369"><a href="#cb22-369"></a><span class="fu">library</span>(tern)</span>
+<span id="cb22-370"><a href="#cb22-370"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-371"><a href="#cb22-371"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb22-372"><a href="#cb22-372"></a></span>
+<span id="cb22-373"><a href="#cb22-373"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-374"><a href="#cb22-374"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb22-375"><a href="#cb22-375"></a><span class="in">```</span></span>
+<span id="cb22-376"><a href="#cb22-376"></a></span>
+<span id="cb22-377"><a href="#cb22-377"></a><span class="fu">#### Death Table</span></span>
+<span id="cb22-378"><a href="#cb22-378"></a></span>
+<span id="cb22-379"><a href="#cb22-379"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb22-380"><a href="#cb22-380"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-381"><a href="#cb22-381"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-382"><a href="#cb22-382"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-383"><a href="#cb22-383"></a>  <span class="fu">count_patients_with_event</span>(</span>
+<span id="cb22-384"><a href="#cb22-384"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb22-385"><a href="#cb22-385"></a>    <span class="at">filters =</span> <span class="fu">c</span>(<span class="st">"AESDTH"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb22-386"><a href="#cb22-386"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Total Number of Deaths"</span>),</span>
+<span id="cb22-387"><a href="#cb22-387"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"xx (xx.xx%)"</span>)</span>
+<span id="cb22-388"><a href="#cb22-388"></a>  )</span>
+<span id="cb22-389"><a href="#cb22-389"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb22-390"><a href="#cb22-390"></a>result</span>
+<span id="cb22-391"><a href="#cb22-391"></a><span class="in">```</span></span>
+<span id="cb22-392"><a href="#cb22-392"></a></span>
+<span id="cb22-393"><a href="#cb22-393"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb22-394"><a href="#cb22-394"></a></span>
+<span id="cb22-395"><a href="#cb22-395"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb22-396"><a href="#cb22-396"></a></span>
+<span id="cb22-397"><a href="#cb22-397"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EUDRAT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Non-Serious Adverse Events Reported in <span class="math inline">\(\geq\)</span> 5% of Patients in Any Treatment Group – Patients and Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>Define a trimming function <code>get_adae_trimmed</code> to filter for AEs of greater than 5% incidence rate.</p>
+<div class="cell" data-hash="eudrat01_cache/html/setup_6b327b3f98f31bcb6753fed187612614">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adae_nonser <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">!=</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ARM)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    anl_terms,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    n_per_arm,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">by =</span> <span class="st">"ARM"</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>    <span class="fu">unique</span>()</span>
+<span id="cb1-37"><a href="#cb1-37"></a></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    anl_terms,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    adae,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  )</span>
+<span id="cb1-43"><a href="#cb1-43"></a>  anl</span>
+<span id="cb1-44"><a href="#cb1-44"></a>}</span>
+<span id="cb1-45"><a href="#cb1-45"></a></span>
+<span id="cb1-46"><a href="#cb1-46"></a>adae_trim <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae_nonser, <span class="at">cutoff_rate =</span> <span class="fl">0.05</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="eudrat01_cache/html/variant1_0e648cde746d34723e589c0ed28b7f67">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5% and number of events"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  )</span>
+<span id="cb2-20"><a href="#cb2-20"></a></span>
+<span id="cb2-21"><a href="#cb2-21"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_trim)</span>
+<span id="cb2-22"><a href="#cb2-22"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                                                                                     A: Drug X                      B: Placebo                    C: Combination        
+  Dictionary-Derived Term                                                                                                            Patients (All)   Events (All)   Patients (All)   Events (All)   Patients (All)   Events (All)
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5% and number of events        106             360             112             367             112             421     
+cl A.1                                                                                                                                                                                                                            
+  dcd A.1.1.1.1                                                                                                                            50              64              45              62              63              88     
+cl B.2                                                                                                                                                                                                                            
+  dcd B.2.1.2.1                                                                                                                            49              65              44              62              52              66     
+cl C.1                                                                                                                                                                                                                            
+  dcd C.1.1.1.3                                                                                                                            43              55              46              63              43              64     
+cl C.2                                                                                                                                                                                                                            
+  dcd C.2.1.2.1                                                                                                                            35              48              48              53              55              65     
+cl D.1                                                                                                                                                                                                                            
+  dcd D.1.1.4.2                                                                                                                            48              66              42              55              50              64     
+cl D.2                                                                                                                                                                                                                            
+  dcd D.2.1.5.3                                                                                                                            47              62              58              72              57              74     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="eudrat01_cache/html/teal_e1ef58e7b49aff49d4732aa6ac387c66">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="eudrat01_cache/html/sessioninfo_07c45c0bf0b9a534a80bfe0c28e4fcde">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       
+[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  
+[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="eudrat01_cache/html/snapshot_4a2322ea4c69fba4f48481d921998179">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disclosures/eudrat01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+    if (mode === "dark") {
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+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
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+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+  toggleBodyColorPrimary();  
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+        if (sheetNode.id === "quarto-bootstrap") {
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+      disableStylesheet(alternateStylesheets);
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+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
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+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
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+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
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+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
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+  // Ensure there is a toggle, if there isn't float one in the top right
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
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+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
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+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
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+        }
+      }
+      return codeEl.innerText;
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+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
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+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
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+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
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+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
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+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
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+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
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+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
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+      content: contentFn,
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+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
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+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
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+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/disclosures/disclosurest01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">DISCLOSUREST01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/disclosures/eudrat02.html" class="pagination-link">
+        <span class="nav-page-text">EUDRAT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> EUDRAT01</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Non-Serious Adverse Events Reported in $\geq$ 5% of Patients in Any Treatment Group -- Patients and Events</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>Define a trimming function <span class="in">`get_adae_trimmed`</span> to filter for AEs of greater than 5% incidence rate.</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a></span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-27"><a href="#cb8-27"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb8-28"><a href="#cb8-28"></a></span>
+<span id="cb8-29"><a href="#cb8-29"></a>adae_nonser <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">!=</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-30"><a href="#cb8-30"></a></span>
+<span id="cb8-31"><a href="#cb8-31"></a>get_adae_trimmed <span class="ot">&lt;-</span> <span class="cf">function</span>(adsl, adae, cutoff_rate) {</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  n_per_arm <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(ARM)</span>
+<span id="cb8-34"><a href="#cb8-34"></a></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  anl_terms <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>    dplyr<span class="sc">::</span><span class="fu">group_by</span>(ARM, AEBODSYS, AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>    dplyr<span class="sc">::</span><span class="fu">count</span>(</span>
+<span id="cb8-38"><a href="#cb8-38"></a>      <span class="at">unique_terms =</span> <span class="fu">n_distinct</span>(USUBJID)</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="sc">-</span>n) <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>    dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb8-42"><a href="#cb8-42"></a></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  anl_terms <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    anl_terms,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    n_per_arm,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">by =</span> <span class="st">"ARM"</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>    dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb8-49"><a href="#cb8-49"></a>      <span class="at">ae_rate =</span> unique_terms <span class="sc">/</span> n</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a>    dplyr<span class="sc">::</span><span class="fu">filter</span>(ae_rate <span class="sc">&gt;=</span> cutoff_rate) <span class="sc">%&gt;%</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>    dplyr<span class="sc">::</span><span class="fu">select</span>(AEDECOD) <span class="sc">%&gt;%</span></span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="fu">unique</span>()</span>
+<span id="cb8-54"><a href="#cb8-54"></a></span>
+<span id="cb8-55"><a href="#cb8-55"></a>  anl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">left_join</span>(</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    anl_terms,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    adae,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">by =</span> <span class="st">"AEDECOD"</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a>  )</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  anl</span>
+<span id="cb8-61"><a href="#cb8-61"></a>}</span>
+<span id="cb8-62"><a href="#cb8-62"></a></span>
+<span id="cb8-63"><a href="#cb8-63"></a>adae_trim <span class="ot">&lt;-</span> <span class="fu">get_adae_trimmed</span>(adsl, adae_nonser, <span class="at">cutoff_rate =</span> <span class="fl">0.05</span>)</span>
+<span id="cb8-64"><a href="#cb8-64"></a><span class="in">```</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a></span>
+<span id="cb8-66"><a href="#cb8-66"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a></span>
+<span id="cb8-68"><a href="#cb8-68"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a><span class="co"># Define the split function</span></span>
+<span id="cb8-70"><a href="#cb8-70"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-71"><a href="#cb8-71"></a></span>
+<span id="cb8-72"><a href="#cb8-72"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-74"><a href="#cb8-74"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb8-75"><a href="#cb8-75"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one non-serious adverse event occuring at a relative frequency of &gt;=5% and number of events"</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-77"><a href="#cb8-77"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-79"><a href="#cb8-79"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-82"><a href="#cb8-82"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb8-83"><a href="#cb8-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-84"><a href="#cb8-84"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_trim<span class="sc">$</span>AEDECOD)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb8-86"><a href="#cb8-86"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-87"><a href="#cb8-87"></a>  )</span>
+<span id="cb8-88"><a href="#cb8-88"></a></span>
+<span id="cb8-89"><a href="#cb8-89"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_trim)</span>
+<span id="cb8-90"><a href="#cb8-90"></a>result</span>
+<span id="cb8-91"><a href="#cb8-91"></a><span class="in">```</span></span>
+<span id="cb8-92"><a href="#cb8-92"></a></span>
+<span id="cb8-93"><a href="#cb8-93"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-94"><a href="#cb8-94"></a></span>
+<span id="cb8-95"><a href="#cb8-95"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a></span>
+<span id="cb8-97"><a href="#cb8-97"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-98"><a href="#cb8-98"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-99"><a href="#cb8-99"></a></span>
+<span id="cb8-100"><a href="#cb8-100"></a><span class="co"># In progress</span></span>
+<span id="cb8-101"><a href="#cb8-101"></a><span class="in">```</span></span>
+<span id="cb8-102"><a href="#cb8-102"></a></span>
+<span id="cb8-103"><a href="#cb8-103"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-104"><a href="#cb8-104"></a></span>
+<span id="cb8-105"><a href="#cb8-105"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/disclosures/eudrat02.html b/stable/tables/disclosures/eudrat02.html
new file mode 100644
index 0000000000..1cad24090a
--- /dev/null
+++ b/stable/tables/disclosures/eudrat02.html
@@ -0,0 +1,2095 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - EUDRAT02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
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+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EUDRAT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Serious Adverse Events, Fatal Serious Adverse Events, and Serious Adverse Events Related to Study Medication</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
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+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>For illustrative purposes, the <code>adae</code> data is filtered by arm <code>A: Drug X</code> here.</p>
+<div class="cell" data-hash="eudrat02_cache/html/setup_d579f62f9f4f58e1d3842c027cfc1608">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae_serious <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adae_serious_arm <span class="ot">&lt;-</span> adae_serious <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>filters_list <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="at">related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>), <span class="st">"Events (Related)"</span>),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="at">fatal =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal)"</span>),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">fatal_related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>, <span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal &amp; Related)"</span>)</span>
+<span id="cb1-17"><a href="#cb1-17"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="eudrat02_cache/html/variant1_b9c741dde83735d7610d316189f4fff0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">empty_stats =</span> <span class="fu">c</span>(<span class="st">"all"</span>, <span class="st">"related"</span>, <span class="st">"fatal"</span>, <span class="st">"fatal_related"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one serious adverse event"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEDECOD)</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  )</span>
+<span id="cb2-26"><a href="#cb2-26"></a></span>
+<span id="cb2-27"><a href="#cb2-27"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_serious_arm)</span>
+<span id="cb2-28"><a href="#cb2-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Body System or Organ Class                                                                                                                                     
+  Dictionary-Derived Term                                          Patients (All)   Events (All)   Events (Related)   Events (Fatal)   Events (Fatal &amp; Related)
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one serious adverse event        104                                                                                    
+cl A.1                                                                                                                                                         
+  dcd A.1.1.1.2                                                          48              68               0                 0                     0            
+cl B.1                                                                                                                                                         
+  dcd B.1.1.1.1                                                          47              56               56                56                    56           
+cl B.2                                                                                                                                                         
+  dcd B.2.2.3.1                                                          48              64               0                 0                     0            
+cl D.1                                                                                                                                                         
+  dcd D.1.1.1.1                                                          50              61               61                61                    61           </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="eudrat02_cache/html/teal_19a5a99c551b5b4efbddad507b6bd64c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="eudrat02_cache/html/sessioninfo_0866b43450672b3b227e4db3ac95d58a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      scda_0.1.6       tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="eudrat02_cache/html/snapshot_c74a4f755ae3d4f2a59b47a96e1b2e9d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disclosures/eudrat02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
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+    const mode = bsSheetEl.getAttribute("data-mode");
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+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+  toggleBodyColorPrimary();  
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+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
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+  const manageTransitions = (selector, allowTransitions) => {
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+        el.classList.add('notransition');
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+        if (sheetNode.id === "quarto-bootstrap") {
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+      disableStylesheet(alternateStylesheets);
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+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
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+    return window.location.protocol === 'file:';
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+    if (styleSentinel !== null) {
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+  // Dark / light mode switch
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+    a.appendChild(i);
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+  // Switch to dark mode if need be
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+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
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+  anchorJS.add('.anchored');
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+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
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+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/disclosures/eudrat01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EUDRAT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/disposition/dst01.html" class="pagination-link">
+        <span class="nav-page-text">DST01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> EUDRAT02</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Serious Adverse Events, Fatal Serious Adverse Events, and Serious Adverse Events Related to Study Medication</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>For illustrative purposes, the <span class="in">`adae`</span> data is filtered by arm <span class="in">`A: Drug X`</span> here.</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a></span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adae)</span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a>adae_serious <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AESER <span class="sc">==</span> <span class="st">"Y"</span>, SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-28"><a href="#cb8-28"></a>adae_serious_arm <span class="ot">&lt;-</span> adae_serious <span class="sc">%&gt;%</span> <span class="fu">filter</span>(ARM <span class="sc">==</span> <span class="st">"A: Drug X"</span>)</span>
+<span id="cb8-29"><a href="#cb8-29"></a></span>
+<span id="cb8-30"><a href="#cb8-30"></a>filters_list <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="at">related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>), <span class="st">"Events (Related)"</span>),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="at">fatal =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal)"</span>),</span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="at">fatal_related =</span> <span class="fu">with_label</span>(<span class="fu">c</span>(<span class="at">AEREL =</span> <span class="st">"Y"</span>, <span class="at">AESDTH =</span> <span class="st">"Y"</span>), <span class="st">"Events (Fatal &amp; Related)"</span>)</span>
+<span id="cb8-34"><a href="#cb8-34"></a>)</span>
+<span id="cb8-35"><a href="#cb8-35"></a><span class="in">```</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a></span>
+<span id="cb8-37"><a href="#cb8-37"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a></span>
+<span id="cb8-39"><a href="#cb8-39"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a><span class="co"># Define the split function</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-42"><a href="#cb8-42"></a></span>
+<span id="cb8-43"><a href="#cb8-43"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">empty_stats =</span> <span class="fu">c</span>(<span class="st">"all"</span>, <span class="st">"related"</span>, <span class="st">"fatal"</span>, <span class="st">"fatal_related"</span>),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">custom_label =</span> <span class="st">"Total number of patients with at least one serious adverse event"</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEBODSYS"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">indent_mod =</span> <span class="sc">-</span>1L,</span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEBODSYS)</span>
+<span id="cb8-55"><a href="#cb8-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AEDECOD"</span>,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adae_serious_arm<span class="sc">$</span>AEDECOD)</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">summarize_patients_events_in_cols</span>(</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    <span class="at">filters_list =</span> filters_list,</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  )</span>
+<span id="cb8-65"><a href="#cb8-65"></a></span>
+<span id="cb8-66"><a href="#cb8-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adae_serious_arm)</span>
+<span id="cb8-67"><a href="#cb8-67"></a>result</span>
+<span id="cb8-68"><a href="#cb8-68"></a><span class="in">```</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-71"><a href="#cb8-71"></a></span>
+<span id="cb8-72"><a href="#cb8-72"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a></span>
+<span id="cb8-74"><a href="#cb8-74"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="co"># In progress</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a><span class="in">```</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a></span>
+<span id="cb8-80"><a href="#cb8-80"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-81"><a href="#cb8-81"></a></span>
+<span id="cb8-82"><a href="#cb8-82"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/tables/disposition/dst01.html b/stable/tables/disposition/dst01.html
new file mode 100644
index 0000000000..089d64ec38
--- /dev/null
+++ b/stable/tables/disposition/dst01.html
@@ -0,0 +1,2392 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - DST01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DST01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Patient Disposition</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Grouping of Reasons</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Adding Optional Rows</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dst01_cache/html/setup_b17644fcb8d93056d056bfc09f5df700">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># reorder EOSSTT factor levels so DISCONTINUED is the last level</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">mutate</span>(<span class="at">EOSSTT =</span> <span class="fu">factor</span>(EOSSTT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"COMPLETED"</span>, <span class="st">"ONGOING"</span>, <span class="st">"DISCONTINUED"</span>)))</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl_gp_added <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">mutate</span>(<span class="at">DCSREASGP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    (DCSREAS <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">&amp;</span> <span class="sc">!</span>DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>)) <span class="sc">~</span> <span class="st">"Non-Safety"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    DCSREAS <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  ) <span class="sc">%&gt;%</span> <span class="fu">factor</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Safety"</span>, <span class="st">"Non-Safety"</span>, <span class="st">"&lt;Missing&gt;"</span>)))</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>adsl_eotstt_added <span class="ot">&lt;-</span> adsl_gp_added <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">EOTSTT =</span> <span class="fu">sample</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="fu">c</span>(<span class="st">"ONGOING"</span>, <span class="st">"COMPLETED"</span>, <span class="st">"DISCONTINUED"</span>),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">factor</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"COMPLETED"</span>, <span class="st">"ONGOING"</span>, <span class="st">"DISCONTINUED"</span>))</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result1&quot;}" data-hash="dst01_cache/html/variant1_6f8a2225d11c6b93bb9ca5ca97dcf0f7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="st">"EOSSTT"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="st">"DCSREAS"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  )</span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>result1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>result1</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                  A: Drug X    B: Placebo   C: Combination   All Patients
+                                   (N=134)      (N=134)        (N=132)         (N=400)   
+—————————————————————————————————————————————————————————————————————————————————————————
+COMPLETED                         68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) 
+ONGOING                           24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) 
+DISCONTINUED                      42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) 
+  ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  
+  DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+  LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  
+  PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  
+  PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   
+  WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  
+  WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result2&quot;}" data-hash="dst01_cache/html/variant2_96300fb8a8c5bf6a9b9d25d1d27f7a17">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="st">"EOSSTT"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DCSREASGP"</span>, <span class="at">indent_mod =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="st">"DCSREAS"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  )</span>
+<span id="cb4-18"><a href="#cb4-18"></a></span>
+<span id="cb4-19"><a href="#cb4-19"></a>tbl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl_gp_added)</span>
+<span id="cb4-20"><a href="#cb4-20"></a>result2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(tbl) <span class="co"># remove rows containing all zeros</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a></span>
+<span id="cb4-22"><a href="#cb4-22"></a>result2</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X    B: Placebo   C: Combination   All Patients
+                                     (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————————————
+COMPLETED                           68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) 
+ONGOING                             24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) 
+DISCONTINUED                        42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) 
+  Safety                                                                                   
+    ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  
+    DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+  Non-Safety                                                                               
+    LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  
+    PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  
+    PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   
+    WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  
+    WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result3&quot;}" data-hash="dst01_cache/html/variant3_ed25928fcecab27b4c696e6131db77ba">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb6-3"><a href="#cb6-3"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="st">"EOTSTT"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>  )</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a>tbl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl_eotstt_added)</span>
+<span id="cb6-13"><a href="#cb6-13"></a>tbl <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(tbl) <span class="co"># remove rows containing all zeros</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a></span>
+<span id="cb6-15"><a href="#cb6-15"></a><span class="co"># Combine tables</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a><span class="fu">col_info</span>(result2) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(tbl)</span>
+<span id="cb6-17"><a href="#cb6-17"></a>result3 <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result2, tbl)</span>
+<span id="cb6-18"><a href="#cb6-18"></a></span>
+<span id="cb6-19"><a href="#cb6-19"></a>result3</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X    B: Placebo   C: Combination   All Patients
+                                     (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————————————
+COMPLETED                           68 (50.7%)   66 (49.3%)     73 (55.3%)     207 (51.7%) 
+ONGOING                             24 (17.9%)   28 (20.9%)     21 (15.9%)      73 (18.2%) 
+DISCONTINUED                        42 (31.3%)   40 (29.9%)     38 (28.8%)     120 (30.0%) 
+  Safety                                                                                   
+    ADVERSE EVENT                    3 (2.2%)     6 (4.5%)       5 (3.8%)       14 (3.5%)  
+    DEATH                           25 (18.7%)   23 (17.2%)     22 (16.7%)      70 (17.5%) 
+  Non-Safety                                                                               
+    LACK OF EFFICACY                 2 (1.5%)     2 (1.5%)       3 (2.3%)        7 (1.8%)  
+    PHYSICIAN DECISION               2 (1.5%)     3 (2.2%)       2 (1.5%)        7 (1.8%)  
+    PROTOCOL VIOLATION               5 (3.7%)     3 (2.2%)        4 (3%)         12 (3%)   
+    WITHDRAWAL BY PARENT/GUARDIAN     4 (3%)      2 (1.5%)       1 (0.8%)        7 (1.8%)  
+    WITHDRAWAL BY SUBJECT            1 (0.7%)     1 (0.7%)       1 (0.8%)        3 (0.8%)  
+COMPLETED                           46 (34.3%)   38 (28.4%)     41 (31.1%)     125 (31.2%) 
+ONGOING                             50 (37.3%)   51 (38.1%)     46 (34.8%)     147 (36.8%) 
+DISCONTINUED                        38 (28.4%)   45 (33.6%)     45 (34.1%)     128 (32.0%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="dst01_cache/html/teal_c85c0fdfb1ee49e6e7f02adba1cb6c39">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-4"><a href="#cb8-4"></a></span>
+<span id="cb8-5"><a href="#cb8-5"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-7"><a href="#cb8-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-8"><a href="#cb8-8"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">DCSREASGP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-11"><a href="#cb8-11"></a>      DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>      (DCSREAS <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">&amp;</span> <span class="sc">!</span>DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>)) <span class="sc">~</span> <span class="st">"Non-Safety"</span>,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>      DCSREAS <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">EOTSTT =</span> <span class="fu">sample</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>      <span class="fu">c</span>(<span class="st">"ONGOING"</span>, <span class="st">"COMPLETED"</span>, <span class="st">"DISCONTINUED"</span>),</span>
+<span id="cb8-17"><a href="#cb8-17"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb8-18"><a href="#cb8-18"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-19"><a href="#cb8-19"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>()</span>
+<span id="cb8-20"><a href="#cb8-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-21"><a href="#cb8-21"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">EOTSTT =</span> <span class="st">"End Of Treatment Status"</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  )</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a>date_vars_asl <span class="ot">&lt;-</span> <span class="fu">names</span>(adsl)[<span class="fu">vapply</span>(adsl, <span class="cf">function</span>(x) <span class="fu">inherits</span>(x, <span class="fu">c</span>(<span class="st">"Date"</span>, <span class="st">"POSIXct"</span>, <span class="st">"POSIXlt"</span>)), <span class="fu">logical</span>(<span class="dv">1</span>))]</span>
+<span id="cb8-26"><a href="#cb8-26"></a>demog_vars_asl <span class="ot">&lt;-</span> <span class="fu">names</span>(adsl)[<span class="sc">!</span>(<span class="fu">names</span>(adsl) <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"STUDYID"</span>, date_vars_asl))]</span>
+<span id="cb8-27"><a href="#cb8-27"></a></span>
+<span id="cb8-28"><a href="#cb8-28"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a><span class="st">     set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a><span class="st">     ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a><span class="st">     ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a><span class="st">     ADSL &lt;- ADSL %&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a><span class="st">        mutate(</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a><span class="st">            DCSREASGP = case_when(</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a><span class="st">                DCSREAS %in% c("ADVERSE EVENT", "DEATH") ~ "Safety",</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a><span class="st">                (DCSREAS != "&lt;Missing&gt;" &amp; !DCSREAS %in% c("ADVERSE EVENT", "DEATH")) ~ "Non-Safety",</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a><span class="st">                DCSREAS == "&lt;Missing&gt;" ~ "&lt;Missing&gt;"</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a><span class="st">    )  %&gt;% as.factor(),</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a><span class="st">    EOTSTT = sample(</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a><span class="st">      c("ONGOING", "COMPLETED", "DISCONTINUED"),</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a><span class="st">      size = nrow(ADSL),</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a><span class="st">      replace = TRUE</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a><span class="st">    ) %&gt;% as.factor()</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a><span class="st">  ) %&gt;% var_relabel(</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a><span class="st">    EOTSTT = "End Of Treatment Status"</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a><span class="st">  )</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a><span class="st">     '</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>  ),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="fu">tm_t_summary</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>      <span class="at">label =</span> <span class="st">"Disposition Table"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-59"><a href="#cb8-59"></a>        <span class="fu">variable_choices</span>(adsl, demog_vars_asl),</span>
+<span id="cb8-60"><a href="#cb8-60"></a>        <span class="fu">c</span>(<span class="st">"EOSSTT"</span>, <span class="st">"DCSREAS"</span>, <span class="st">"EOTSTT"</span>)</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      ),</span>
+<span id="cb8-62"><a href="#cb8-62"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a>    )</span>
+<span id="cb8-64"><a href="#cb8-64"></a>  )</span>
+<span id="cb8-65"><a href="#cb8-65"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:34:07.0285 pid:13383 token:[] teal.modules.clinical Initializing tm_t_summary</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="dst01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dst01_cache/html/sessioninfo_fa21c9ef58facd0e644c2b2882e48b46">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dst01_cache/html/snapshot_7cee6424e69ef676675167810caee3cb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disposition/dst01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+      bodyEl.classList.remove("quarto-light");
+    } else {
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+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
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+      disableStylesheet(alternateStylesheets);
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+    toggleColorMode(true);
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+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
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+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
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+          details.removeAttribute("open");
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+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
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+  }
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+  }
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+  for (var i=0; i<noterefs.length; i++) {
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+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+              parent.appendChild(div);
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+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> DST01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Patient Disposition</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a></span>
+<span id="cb14-20"><a href="#cb14-20"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a></span>
+<span id="cb14-23"><a href="#cb14-23"></a><span class="co"># reorder EOSSTT factor levels so DISCONTINUED is the last level</span></span>
+<span id="cb14-24"><a href="#cb14-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a>  <span class="fu">mutate</span>(<span class="at">EOSSTT =</span> <span class="fu">factor</span>(EOSSTT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"COMPLETED"</span>, <span class="st">"ONGOING"</span>, <span class="st">"DISCONTINUED"</span>)))</span>
+<span id="cb14-26"><a href="#cb14-26"></a></span>
+<span id="cb14-27"><a href="#cb14-27"></a>adsl_gp_added <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-28"><a href="#cb14-28"></a>  <span class="fu">mutate</span>(<span class="at">DCSREASGP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-29"><a href="#cb14-29"></a>    DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb14-30"><a href="#cb14-30"></a>    (DCSREAS <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">&amp;</span> <span class="sc">!</span>DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>)) <span class="sc">~</span> <span class="st">"Non-Safety"</span>,</span>
+<span id="cb14-31"><a href="#cb14-31"></a>    DCSREAS <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb14-32"><a href="#cb14-32"></a>  ) <span class="sc">%&gt;%</span> <span class="fu">factor</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Safety"</span>, <span class="st">"Non-Safety"</span>, <span class="st">"&lt;Missing&gt;"</span>)))</span>
+<span id="cb14-33"><a href="#cb14-33"></a></span>
+<span id="cb14-34"><a href="#cb14-34"></a>adsl_eotstt_added <span class="ot">&lt;-</span> adsl_gp_added <span class="sc">%&gt;%</span></span>
+<span id="cb14-35"><a href="#cb14-35"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-36"><a href="#cb14-36"></a>    <span class="at">EOTSTT =</span> <span class="fu">sample</span>(</span>
+<span id="cb14-37"><a href="#cb14-37"></a>      <span class="fu">c</span>(<span class="st">"ONGOING"</span>, <span class="st">"COMPLETED"</span>, <span class="st">"DISCONTINUED"</span>),</span>
+<span id="cb14-38"><a href="#cb14-38"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb14-39"><a href="#cb14-39"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">factor</span>(<span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"COMPLETED"</span>, <span class="st">"ONGOING"</span>, <span class="st">"DISCONTINUED"</span>))</span>
+<span id="cb14-41"><a href="#cb14-41"></a>  )</span>
+<span id="cb14-42"><a href="#cb14-42"></a><span class="in">```</span></span>
+<span id="cb14-43"><a href="#cb14-43"></a></span>
+<span id="cb14-44"><a href="#cb14-44"></a><span class="fu">## Standard Table</span></span>
+<span id="cb14-45"><a href="#cb14-45"></a></span>
+<span id="cb14-46"><a href="#cb14-46"></a><span class="in">```{r variant1, test = list(result_v1 = "result1")}</span></span>
+<span id="cb14-47"><a href="#cb14-47"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-48"><a href="#cb14-48"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb14-49"><a href="#cb14-49"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb14-50"><a href="#cb14-50"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb14-51"><a href="#cb14-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-52"><a href="#cb14-52"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb14-53"><a href="#cb14-53"></a>    <span class="st">"EOSSTT"</span>,</span>
+<span id="cb14-54"><a href="#cb14-54"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-55"><a href="#cb14-55"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-56"><a href="#cb14-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-57"><a href="#cb14-57"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-58"><a href="#cb14-58"></a>    <span class="st">"DCSREAS"</span>,</span>
+<span id="cb14-59"><a href="#cb14-59"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-60"><a href="#cb14-60"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb14-61"><a href="#cb14-61"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb14-62"><a href="#cb14-62"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L)</span>
+<span id="cb14-63"><a href="#cb14-63"></a>  )</span>
+<span id="cb14-64"><a href="#cb14-64"></a></span>
+<span id="cb14-65"><a href="#cb14-65"></a>result1 <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl)</span>
+<span id="cb14-66"><a href="#cb14-66"></a>result1</span>
+<span id="cb14-67"><a href="#cb14-67"></a><span class="in">```</span></span>
+<span id="cb14-68"><a href="#cb14-68"></a></span>
+<span id="cb14-69"><a href="#cb14-69"></a><span class="fu">## Table with Grouping of Reasons</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a></span>
+<span id="cb14-71"><a href="#cb14-71"></a><span class="in">```{r variant2, test = list(result_v2 = "result2")}</span></span>
+<span id="cb14-72"><a href="#cb14-72"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-73"><a href="#cb14-73"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb14-76"><a href="#cb14-76"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb14-78"><a href="#cb14-78"></a>    <span class="st">"EOSSTT"</span>,</span>
+<span id="cb14-79"><a href="#cb14-79"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-80"><a href="#cb14-80"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-81"><a href="#cb14-81"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-82"><a href="#cb14-82"></a>  <span class="fu">split_rows_by</span>(<span class="st">"DCSREASGP"</span>, <span class="at">indent_mod =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb14-83"><a href="#cb14-83"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-84"><a href="#cb14-84"></a>    <span class="st">"DCSREAS"</span>,</span>
+<span id="cb14-85"><a href="#cb14-85"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-86"><a href="#cb14-86"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span>,</span>
+<span id="cb14-87"><a href="#cb14-87"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-88"><a href="#cb14-88"></a>  )</span>
+<span id="cb14-89"><a href="#cb14-89"></a></span>
+<span id="cb14-90"><a href="#cb14-90"></a>tbl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl_gp_added)</span>
+<span id="cb14-91"><a href="#cb14-91"></a>result2 <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(tbl) <span class="co"># remove rows containing all zeros</span></span>
+<span id="cb14-92"><a href="#cb14-92"></a></span>
+<span id="cb14-93"><a href="#cb14-93"></a>result2</span>
+<span id="cb14-94"><a href="#cb14-94"></a><span class="in">```</span></span>
+<span id="cb14-95"><a href="#cb14-95"></a></span>
+<span id="cb14-96"><a href="#cb14-96"></a><span class="fu">## Table Adding Optional Rows</span></span>
+<span id="cb14-97"><a href="#cb14-97"></a></span>
+<span id="cb14-98"><a href="#cb14-98"></a><span class="in">```{r variant3, test = list(result_v3 = "result3")}</span></span>
+<span id="cb14-99"><a href="#cb14-99"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-100"><a href="#cb14-100"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb14-101"><a href="#cb14-101"></a>    <span class="st">"ACTARM"</span>,</span>
+<span id="cb14-102"><a href="#cb14-102"></a>    <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"All Patients"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb14-103"><a href="#cb14-103"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-104"><a href="#cb14-104"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb14-105"><a href="#cb14-105"></a>    <span class="st">"EOTSTT"</span>,</span>
+<span id="cb14-106"><a href="#cb14-106"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb14-107"><a href="#cb14-107"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb14-108"><a href="#cb14-108"></a>  )</span>
+<span id="cb14-109"><a href="#cb14-109"></a></span>
+<span id="cb14-110"><a href="#cb14-110"></a>tbl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adsl_eotstt_added)</span>
+<span id="cb14-111"><a href="#cb14-111"></a>tbl <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(tbl) <span class="co"># remove rows containing all zeros</span></span>
+<span id="cb14-112"><a href="#cb14-112"></a></span>
+<span id="cb14-113"><a href="#cb14-113"></a><span class="co"># Combine tables</span></span>
+<span id="cb14-114"><a href="#cb14-114"></a><span class="fu">col_info</span>(result2) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(tbl)</span>
+<span id="cb14-115"><a href="#cb14-115"></a>result3 <span class="ot">&lt;-</span> <span class="fu">rbind</span>(result2, tbl)</span>
+<span id="cb14-116"><a href="#cb14-116"></a></span>
+<span id="cb14-117"><a href="#cb14-117"></a>result3</span>
+<span id="cb14-118"><a href="#cb14-118"></a><span class="in">```</span></span>
+<span id="cb14-119"><a href="#cb14-119"></a></span>
+<span id="cb14-120"><a href="#cb14-120"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-121"><a href="#cb14-121"></a></span>
+<span id="cb14-122"><a href="#cb14-122"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-123"><a href="#cb14-123"></a></span>
+<span id="cb14-124"><a href="#cb14-124"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-125"><a href="#cb14-125"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb14-126"><a href="#cb14-126"></a></span>
+<span id="cb14-127"><a href="#cb14-127"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-128"><a href="#cb14-128"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-129"><a href="#cb14-129"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-130"><a href="#cb14-130"></a></span>
+<span id="cb14-131"><a href="#cb14-131"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb14-132"><a href="#cb14-132"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-133"><a href="#cb14-133"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-134"><a href="#cb14-134"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-135"><a href="#cb14-135"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-136"><a href="#cb14-136"></a>    <span class="at">DCSREASGP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-137"><a href="#cb14-137"></a>      DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>) <span class="sc">~</span> <span class="st">"Safety"</span>,</span>
+<span id="cb14-138"><a href="#cb14-138"></a>      (DCSREAS <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">&amp;</span> <span class="sc">!</span>DCSREAS <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ADVERSE EVENT"</span>, <span class="st">"DEATH"</span>)) <span class="sc">~</span> <span class="st">"Non-Safety"</span>,</span>
+<span id="cb14-139"><a href="#cb14-139"></a>      DCSREAS <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"&lt;Missing&gt;"</span></span>
+<span id="cb14-140"><a href="#cb14-140"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>(),</span>
+<span id="cb14-141"><a href="#cb14-141"></a>    <span class="at">EOTSTT =</span> <span class="fu">sample</span>(</span>
+<span id="cb14-142"><a href="#cb14-142"></a>      <span class="fu">c</span>(<span class="st">"ONGOING"</span>, <span class="st">"COMPLETED"</span>, <span class="st">"DISCONTINUED"</span>),</span>
+<span id="cb14-143"><a href="#cb14-143"></a>      <span class="at">size =</span> <span class="fu">nrow</span>(adsl),</span>
+<span id="cb14-144"><a href="#cb14-144"></a>      <span class="at">replace =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-145"><a href="#cb14-145"></a>    ) <span class="sc">%&gt;%</span> <span class="fu">as.factor</span>()</span>
+<span id="cb14-146"><a href="#cb14-146"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-147"><a href="#cb14-147"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb14-148"><a href="#cb14-148"></a>    <span class="at">EOTSTT =</span> <span class="st">"End Of Treatment Status"</span></span>
+<span id="cb14-149"><a href="#cb14-149"></a>  )</span>
+<span id="cb14-150"><a href="#cb14-150"></a></span>
+<span id="cb14-151"><a href="#cb14-151"></a>date_vars_asl <span class="ot">&lt;-</span> <span class="fu">names</span>(adsl)[<span class="fu">vapply</span>(adsl, <span class="cf">function</span>(x) <span class="fu">inherits</span>(x, <span class="fu">c</span>(<span class="st">"Date"</span>, <span class="st">"POSIXct"</span>, <span class="st">"POSIXlt"</span>)), <span class="fu">logical</span>(<span class="dv">1</span>))]</span>
+<span id="cb14-152"><a href="#cb14-152"></a>demog_vars_asl <span class="ot">&lt;-</span> <span class="fu">names</span>(adsl)[<span class="sc">!</span>(<span class="fu">names</span>(adsl) <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"STUDYID"</span>, date_vars_asl))]</span>
+<span id="cb14-153"><a href="#cb14-153"></a></span>
+<span id="cb14-154"><a href="#cb14-154"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-155"><a href="#cb14-155"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-156"><a href="#cb14-156"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb14-157"><a href="#cb14-157"></a>    <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb14-158"><a href="#cb14-158"></a><span class="st">     set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb14-159"><a href="#cb14-159"></a><span class="st">     ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb14-160"><a href="#cb14-160"></a><span class="st">     ADSL &lt;- df_explicit_na(ADSL)</span></span>
+<span id="cb14-161"><a href="#cb14-161"></a><span class="st">     ADSL &lt;- ADSL %&gt;%</span></span>
+<span id="cb14-162"><a href="#cb14-162"></a><span class="st">        mutate(</span></span>
+<span id="cb14-163"><a href="#cb14-163"></a><span class="st">            DCSREASGP = case_when(</span></span>
+<span id="cb14-164"><a href="#cb14-164"></a><span class="st">                DCSREAS %in% c("ADVERSE EVENT", "DEATH") ~ "Safety",</span></span>
+<span id="cb14-165"><a href="#cb14-165"></a><span class="st">                (DCSREAS != "&lt;Missing&gt;" &amp; !DCSREAS %in% c("ADVERSE EVENT", "DEATH")) ~ "Non-Safety",</span></span>
+<span id="cb14-166"><a href="#cb14-166"></a><span class="st">                DCSREAS == "&lt;Missing&gt;" ~ "&lt;Missing&gt;"</span></span>
+<span id="cb14-167"><a href="#cb14-167"></a><span class="st">    )  %&gt;% as.factor(),</span></span>
+<span id="cb14-168"><a href="#cb14-168"></a><span class="st">    EOTSTT = sample(</span></span>
+<span id="cb14-169"><a href="#cb14-169"></a><span class="st">      c("ONGOING", "COMPLETED", "DISCONTINUED"),</span></span>
+<span id="cb14-170"><a href="#cb14-170"></a><span class="st">      size = nrow(ADSL),</span></span>
+<span id="cb14-171"><a href="#cb14-171"></a><span class="st">      replace = TRUE</span></span>
+<span id="cb14-172"><a href="#cb14-172"></a><span class="st">    ) %&gt;% as.factor()</span></span>
+<span id="cb14-173"><a href="#cb14-173"></a><span class="st">  ) %&gt;% var_relabel(</span></span>
+<span id="cb14-174"><a href="#cb14-174"></a><span class="st">    EOTSTT = "End Of Treatment Status"</span></span>
+<span id="cb14-175"><a href="#cb14-175"></a><span class="st">  )</span></span>
+<span id="cb14-176"><a href="#cb14-176"></a><span class="st">     '</span>,</span>
+<span id="cb14-177"><a href="#cb14-177"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-178"><a href="#cb14-178"></a>  ),</span>
+<span id="cb14-179"><a href="#cb14-179"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-180"><a href="#cb14-180"></a>    <span class="fu">tm_t_summary</span>(</span>
+<span id="cb14-181"><a href="#cb14-181"></a>      <span class="at">label =</span> <span class="st">"Disposition Table"</span>,</span>
+<span id="cb14-182"><a href="#cb14-182"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb14-183"><a href="#cb14-183"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb14-184"><a href="#cb14-184"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-185"><a href="#cb14-185"></a>        <span class="fu">variable_choices</span>(adsl, demog_vars_asl),</span>
+<span id="cb14-186"><a href="#cb14-186"></a>        <span class="fu">c</span>(<span class="st">"EOSSTT"</span>, <span class="st">"DCSREAS"</span>, <span class="st">"EOTSTT"</span>)</span>
+<span id="cb14-187"><a href="#cb14-187"></a>      ),</span>
+<span id="cb14-188"><a href="#cb14-188"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span></span>
+<span id="cb14-189"><a href="#cb14-189"></a>    )</span>
+<span id="cb14-190"><a href="#cb14-190"></a>  )</span>
+<span id="cb14-191"><a href="#cb14-191"></a>)</span>
+<span id="cb14-192"><a href="#cb14-192"></a></span>
+<span id="cb14-193"><a href="#cb14-193"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-194"><a href="#cb14-194"></a><span class="in">```</span></span>
+<span id="cb14-195"><a href="#cb14-195"></a></span>
+<span id="cb14-196"><a href="#cb14-196"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-197"><a href="#cb14-197"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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\ No newline at end of file
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+</li>
+          <li class="sidebar-item">
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+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+ <span class="menu-text">AET09</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="true">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PDT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Major Protocol Deviations</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pdt01_cache/html/setup_bb5b4e7243e75e54e6b34c46c060cbb6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>addv <span class="ot">&lt;-</span> addv <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">DVDECOD =</span> <span class="st">"Category"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">DVTERM =</span> <span class="st">"Description"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pdt01_cache/html/variant1_5090d7ae931ff3d8c2ad109c1fa6500b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one major protocol deviation"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of major protocol deviations"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>    )</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="st">"DVDECOD"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(addv<span class="sc">$</span>DVDECOD)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"DVTERM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">append_varlabels</span>(addv, <span class="st">"DVTERM"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-21"><a href="#cb2-21"></a></span>
+<span id="cb2-22"><a href="#cb2-22"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> addv, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"DVDECOD"</span>, <span class="st">"*"</span>, <span class="st">"DVTERM"</span>), <span class="at">scorefun =</span> score_occurrences)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Category                                                              A: Drug X    B: Placebo   C: Combination
+  Description                                                          (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one major protocol deviation   28 (20.9%)   22 (16.4%)     18 (13.6%)  
+Total number of major protocol deviations                                 49           35             35      
+EXCLUSION CRITERIA                                                                                            
+  Active or untreated or other excluded cns metastases                 2 (1.5%)     4 (3.0%)       1 (0.8%)   
+  Pregnancy criteria                                                   3 (2.2%)     3 (2.2%)       1 (0.8%)   
+  History of other malignancies within the last 5 years                3 (2.2%)     1 (0.7%)       1 (0.8%)   
+  Uncontrolled concurrent condition                                    2 (1.5%)        0           3 (2.3%)   
+  Other exclusion criteria                                             1 (0.7%)        0           2 (1.5%)   
+  Received prior prohibited therapy or medication                      2 (1.5%)     1 (0.7%)          0       
+INCLUSION CRITERIA                                                                                            
+  No signed ICF at study entry                                         5 (3.7%)        0           6 (4.5%)   
+  Ineligible cancer type or current cancer stage                       3 (2.2%)     2 (1.5%)       4 (3.0%)   
+  Inclusion lab values outside allowed limits                          4 (3.0%)     1 (0.7%)          0       
+  Does not meet prior therapy requirements                             2 (1.5%)     1 (0.7%)       1 (0.8%)   
+  Inclusion-related test not done/out of window                        1 (0.7%)     1 (0.7%)          0       
+MEDICATION                                                                                                    
+  Discontinued study drug for unspecified reason                       3 (2.2%)     2 (1.5%)       1 (0.8%)   
+  Significant deviation from planned dose                              3 (2.2%)     1 (0.7%)       2 (1.5%)   
+  Received incorrect study medication                                     0         3 (2.2%)       1 (0.8%)   
+  Received prohibited concomitant medication                           1 (0.7%)     2 (1.5%)       1 (0.8%)   
+  Dose missed or significantly out of window                           2 (1.5%)        0           1 (0.8%)   
+PROCEDURAL                                                                                                    
+  Eligibility-related test not done/out of window                      2 (1.5%)     4 (3.0%)       3 (2.3%)   
+  Omission of screening tumor assessment                               4 (3.0%)     1 (0.7%)       3 (2.3%)   
+  Missed assessment affecting safety/study outcomes                    2 (1.5%)     3 (2.2%)       1 (0.8%)   
+  Failure to sign updated ICF within two visits                        2 (1.5%)     1 (0.7%)       1 (0.8%)   
+  Missed 2 or more efficacy assessments                                1 (0.7%)     2 (1.5%)          0       
+  Omission of complete lab panel required by protocol                     0            0           1 (0.8%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="pdt01_cache/html/teal_71c2e7ae28539b4eb2ba3d8bbe88195d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADDV"</span>, addv, <span class="at">code =</span> <span class="st">'ADDV &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "addv"))'</span>),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="at">label =</span> <span class="st">"Major Protocol Deviations Table"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      <span class="at">dataname =</span> <span class="st">"ADDV"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(addv, <span class="fu">c</span>(<span class="st">"DVTERM"</span>)),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"DVTERM"</span>)</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      ),</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-28"><a href="#cb4-28"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(addv, <span class="fu">c</span>(<span class="st">"DVDECOD"</span>)),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>        <span class="at">selected =</span> <span class="st">"DVDECOD"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>      ),</span>
+<span id="cb4-31"><a href="#cb4-31"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      <span class="at">event_type =</span> <span class="st">"major protocol deviation"</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a>    )</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  )</span>
+<span id="cb4-35"><a href="#cb4-35"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:34:45.1909 pid:13481 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="pdt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pdt01_cache/html/sessioninfo_e65e54f661b6d44183e457eb83b3fae7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pdt01_cache/html/snapshot_761134d41f7d04159e9b90c3ed7c84d0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disposition/pdt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+          citeDiv.classList.add('csl-entry');
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/disposition/dst01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">DST01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/disposition/pdt02.html" class="pagination-link">
+        <span class="nav-page-text">PDT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> PDT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Major Protocol Deviations</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a>addv <span class="ot">&lt;-</span> addv <span class="sc">%&gt;%</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    <span class="at">DVDECOD =</span> <span class="st">"Category"</span>,</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    <span class="at">DVTERM =</span> <span class="st">"Description"</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  )</span>
+<span id="cb10-32"><a href="#cb10-32"></a><span class="in">```</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a></span>
+<span id="cb10-34"><a href="#cb10-34"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a></span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-45"><a href="#cb10-45"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one major protocol deviation"</span>,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of major protocol deviations"</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>    )</span>
+<span id="cb10-48"><a href="#cb10-48"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="st">"DVDECOD"</span>,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(addv<span class="sc">$</span>DVDECOD)</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"DVTERM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="fu">append_varlabels</span>(addv, <span class="st">"DVTERM"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb10-57"><a href="#cb10-57"></a></span>
+<span id="cb10-58"><a href="#cb10-58"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> addv, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"DVDECOD"</span>, <span class="st">"*"</span>, <span class="st">"DVTERM"</span>), <span class="at">scorefun =</span> score_occurrences)</span>
+<span id="cb10-61"><a href="#cb10-61"></a></span>
+<span id="cb10-62"><a href="#cb10-62"></a>result</span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="in">```</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-66"><a href="#cb10-66"></a></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a></span>
+<span id="cb10-69"><a href="#cb10-69"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-73"><a href="#cb10-73"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-75"><a href="#cb10-75"></a></span>
+<span id="cb10-76"><a href="#cb10-76"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-77"><a href="#cb10-77"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb10-78"><a href="#cb10-78"></a></span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-81"><a href="#cb10-81"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-85"><a href="#cb10-85"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb10-86"><a href="#cb10-86"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADDV"</span>, addv, <span class="at">code =</span> <span class="st">'ADDV &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "addv"))'</span>),</span>
+<span id="cb10-87"><a href="#cb10-87"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a>  ),</span>
+<span id="cb10-89"><a href="#cb10-89"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-90"><a href="#cb10-90"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb10-91"><a href="#cb10-91"></a>      <span class="at">label =</span> <span class="st">"Major Protocol Deviations Table"</span>,</span>
+<span id="cb10-92"><a href="#cb10-92"></a>      <span class="at">dataname =</span> <span class="st">"ADDV"</span>,</span>
+<span id="cb10-93"><a href="#cb10-93"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-94"><a href="#cb10-94"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-95"><a href="#cb10-95"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(addv, <span class="fu">c</span>(<span class="st">"DVTERM"</span>)),</span>
+<span id="cb10-96"><a href="#cb10-96"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"DVTERM"</span>)</span>
+<span id="cb10-97"><a href="#cb10-97"></a>      ),</span>
+<span id="cb10-98"><a href="#cb10-98"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-99"><a href="#cb10-99"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(addv, <span class="fu">c</span>(<span class="st">"DVDECOD"</span>)),</span>
+<span id="cb10-100"><a href="#cb10-100"></a>        <span class="at">selected =</span> <span class="st">"DVDECOD"</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a>      ),</span>
+<span id="cb10-102"><a href="#cb10-102"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-103"><a href="#cb10-103"></a>      <span class="at">event_type =</span> <span class="st">"major protocol deviation"</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a>    )</span>
+<span id="cb10-105"><a href="#cb10-105"></a>  )</span>
+<span id="cb10-106"><a href="#cb10-106"></a>)</span>
+<span id="cb10-107"><a href="#cb10-107"></a></span>
+<span id="cb10-108"><a href="#cb10-108"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-109"><a href="#cb10-109"></a><span class="in">```</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a></span>
+<span id="cb10-111"><a href="#cb10-111"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-112"><a href="#cb10-112"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="true">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PDT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Major Protocol Deviations Related to Epidemic/Pandemic</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pdt02_cache/html/setup_517e57083c8951afe06ec0b8a844b885">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>addv_pan <span class="ot">&lt;-</span> addv <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(AEPRELFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> DVCAT <span class="sc">==</span> <span class="st">"MAJOR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">DVREAS =</span> <span class="st">"Primary Reason"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">DVTERM =</span> <span class="st">"Description"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pdt02_cache/html/variant1_ec3727209e4bdda07f11d36a8d13e9e3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one major protocol deviation related to epidemic/pandemic"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of major protocol deviations related to epidemic/pandemic"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>    )</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="st">"DVREAS"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(addv_pan<span class="sc">$</span>DVREAS)</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">.labels =</span> <span class="st">"Site action due to epidemic/pandemic"</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"DVTERM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">append_varlabels</span>(addv_pan, <span class="st">"DVTERM"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, addv_pan, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-27"><a href="#cb2-27"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Primary Reason                                                                                     A: Drug X   B: Placebo   C: Combination
+  Description                                                                                       (N=134)     (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one major protocol deviation related to epidemic/pandemic   8 (6.0%)     4 (3.0%)       4 (3.0%)   
+Total number of major protocol deviations related to epidemic/pandemic                                 8           5              4       
+Site action due to epidemic/pandemic                                                               8 (6.0%)     4 (3.0%)       4 (3.0%)   
+  Dose missed or significantly out of window                                                       2 (1.5%)        0           1 (0.8%)   
+  Failure to sign updated ICF within two visits                                                    2 (1.5%)     1 (0.7%)       1 (0.8%)   
+  Missed 2 or more efficacy assessments                                                            1 (0.7%)     2 (1.5%)          0       
+  Significant deviation from planned dose                                                          3 (2.2%)     1 (0.7%)       2 (1.5%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pdt02_cache/html/teal_de832c7d49e6a17724f33f589cf96ddb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pdt02_cache/html/sessioninfo_f488382805380c307898f5ca3573d9f8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pdt02_cache/html/snapshot_edbfd6bb35a7e6b697497fa80e836e17">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/disposition/pdt02.lock">Download</a></p>
+</section>
+</div>
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+</div>
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+  }
+  const isFileUrl = () => { 
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+    // flash "checked"
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+  function toggleCodeHandler(show) {
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+  if (showAllCode) {
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+  function tippyHover(el, contentFn) {
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+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
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+            div.style.top = top - 2 + "px";
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+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
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+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
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+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/disposition/pdt01.html" class="pagination-link">
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+  </div>
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+      <a href="../../tables/ECG/egt01.html" class="pagination-link">
+        <span class="nav-page-text">EGT01</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PDT02</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Major Protocol Deviations Related to Epidemic/Pandemic</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>addv <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"addv"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a></span>
+<span id="cb8-23"><a href="#cb8-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-24"><a href="#cb8-24"></a>addv <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(addv)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a>addv_pan <span class="ot">&lt;-</span> addv <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">filter</span>(AEPRELFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> DVCAT <span class="sc">==</span> <span class="st">"MAJOR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="at">DVREAS =</span> <span class="st">"Primary Reason"</span>,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">DVTERM =</span> <span class="st">"Description"</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  )</span>
+<span id="cb8-32"><a href="#cb8-32"></a><span class="in">```</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a></span>
+<span id="cb8-36"><a href="#cb8-36"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-43"><a href="#cb8-43"></a>      <span class="at">unique =</span> <span class="st">"Total number of patients with at least one major protocol deviation related to epidemic/pandemic"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="at">nonunique =</span> <span class="st">"Total number of major protocol deviations related to epidemic/pandemic"</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>    )</span>
+<span id="cb8-46"><a href="#cb8-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="st">"DVREAS"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(addv_pan<span class="sc">$</span>DVREAS)</span>
+<span id="cb8-53"><a href="#cb8-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">.labels =</span> <span class="st">"Site action due to epidemic/pandemic"</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"DVTERM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>  <span class="fu">append_varlabels</span>(addv_pan, <span class="st">"DVTERM"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb8-61"><a href="#cb8-61"></a></span>
+<span id="cb8-62"><a href="#cb8-62"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, addv_pan, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-63"><a href="#cb8-63"></a>result</span>
+<span id="cb8-64"><a href="#cb8-64"></a><span class="in">```</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a></span>
+<span id="cb8-66"><a href="#cb8-66"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-67"><a href="#cb8-67"></a></span>
+<span id="cb8-68"><a href="#cb8-68"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a><span class="co"># In progress</span></span>
+<span id="cb8-74"><a href="#cb8-74"></a><span class="in">```</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a></span>
+<span id="cb8-76"><a href="#cb8-76"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-77"><a href="#cb8-77"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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new file mode 100644
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AOVT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ANCOVA for Multiple End Points</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aovt01_cache/html/setup_fad4a3340422272608934f073d8e8cab">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adqs_multi <span class="ot">&lt;-</span> <span class="fu">filter</span>(adqs, AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aovt01_cache/html/variant1_0e72dac8a9c217a27215ec2fc4b0a024">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>l <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCD"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs_multi<span class="sc">$</span>PARAMCD)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>      <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>      <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    ),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted mean"</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  )</span>
+<span id="cb2-20"><a href="#cb2-20"></a></span>
+<span id="cb2-21"><a href="#cb2-21"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">lyt =</span> l,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">df =</span> adqs_multi,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-25"><a href="#cb2-25"></a>)</span>
+<span id="cb2-26"><a href="#cb2-26"></a></span>
+<span id="cb2-27"><a href="#cb2-27"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                     ARM A       ARM B           ARM C    
+————————————————————————————————————————————————————————————————————————
+BFIALL                                                                  
+  Adjusted mean                                                         
+    n                               134         134             132     
+    Adjusted Mean                  4.47        6.33            4.02     
+    Difference in Adjusted Means               1.85            -0.46    
+      95% CI                               (-0.14, 3.85)   (-2.45, 1.54)
+      p-value                                 0.0679          0.6539    
+FATIGI                                                                  
+  Adjusted mean                                                         
+    n                               134         134             132     
+    Adjusted Mean                  5.42        4.83            4.56     
+    Difference in Adjusted Means               -0.59           -0.86    
+      95% CI                               (-2.58, 1.41)   (-2.87, 1.15)
+      p-value                                 0.5644          0.4026    
+FKSI-FWB                                                                
+  Adjusted mean                                                         
+    n                               134         134             132     
+    Adjusted Mean                  4.29        3.51            3.06     
+    Difference in Adjusted Means               -0.79           -1.24    
+      95% CI                               (-2.71, 1.14)   (-3.17, 0.69)
+      p-value                                 0.4221          0.2088    
+FKSI-TSE                                                                
+  Adjusted mean                                                         
+    n                               134         134             132     
+    Adjusted Mean                  4.70        3.84            4.45     
+    Difference in Adjusted Means               -0.86           -0.25    
+      95% CI                               (-2.80, 1.09)   (-2.20, 1.70)
+      p-value                                 0.3858          0.8007    
+FKSIALL                                                                 
+  Adjusted mean                                                         
+    n                               134         134             132     
+    Adjusted Mean                  5.03        5.82            6.44     
+    Difference in Adjusted Means               0.79            1.42     
+      95% CI                               (-1.17, 2.76)   (-0.56, 3.39)
+      p-value                                 0.4288          0.1591    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aovt01_cache/html/teal_40fee35641600b27eae1dda8340fb3e6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-9"><a href="#cb4-9"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  ),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  )</span>
+<span id="cb4-20"><a href="#cb4-20"></a>)</span>
+<span id="cb4-21"><a href="#cb4-21"></a></span>
+<span id="cb4-22"><a href="#cb4-22"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">code =</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a><span class="st">       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span>,</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  ),</span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="fu">tm_t_ancova</span>(</span>
+<span id="cb4-33"><a href="#cb4-33"></a>      <span class="at">label =</span> <span class="st">"ANCOVA table"</span>,</span>
+<span id="cb4-34"><a href="#cb4-34"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">avisit =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"AVISIT"</span>),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>        <span class="at">selected =</span> <span class="st">"WEEK 1 DAY 8"</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a>      ),</span>
+<span id="cb4-39"><a href="#cb4-39"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-40"><a href="#cb4-40"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb4-41"><a href="#cb4-41"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-42"><a href="#cb4-42"></a>      ),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-45"><a href="#cb4-45"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"CHG"</span>, <span class="st">"AVAL"</span>)),</span>
+<span id="cb4-46"><a href="#cb4-46"></a>        <span class="at">selected =</span> <span class="st">"CHG"</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>      ),</span>
+<span id="cb4-48"><a href="#cb4-48"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-49"><a href="#cb4-49"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb4-50"><a href="#cb4-50"></a>        <span class="at">selected =</span> <span class="st">"STRATA1"</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>      ),</span>
+<span id="cb4-52"><a href="#cb4-52"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-53"><a href="#cb4-53"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-54"><a href="#cb4-54"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"FKSI-FWB"</span>, <span class="st">"BFIALL"</span>)</span>
+<span id="cb4-55"><a href="#cb4-55"></a>      )</span>
+<span id="cb4-56"><a href="#cb4-56"></a>    )</span>
+<span id="cb4-57"><a href="#cb4-57"></a>  )</span>
+<span id="cb4-58"><a href="#cb4-58"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:03:21.3759 pid:8051 token:[] teal.modules.clinical Initializing tm_t_ancova</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aovt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aovt01_cache/html/sessioninfo_2a79c52076bef36bbc4e96c3da79d5fd">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aovt01_cache/html/snapshot_df12346d0b09a8afe9a074b55c745f1b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/aovt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+    if (parentEl) {
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+      }
+    } else {
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/ECG/egt05_qtcat.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">EGT05_QTCAT</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/aovt02.html" class="pagination-link">
+        <span class="nav-page-text">AOVT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> AOVT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> ANCOVA for Multiple End Points</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adqs_multi <span class="ot">&lt;-</span> <span class="fu">filter</span>(adqs, AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>)</span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="in">```</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a></span>
+<span id="cb10-32"><a href="#cb10-32"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a><span class="co"># Define the split function</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-35"><a href="#cb10-35"></a></span>
+<span id="cb10-36"><a href="#cb10-36"></a>l <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCD"</span>,</span>
+<span id="cb10-39"><a href="#cb10-39"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs_multi<span class="sc">$</span>PARAMCD)</span>
+<span id="cb10-42"><a href="#cb10-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb10-46"><a href="#cb10-46"></a>      <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb10-47"><a href="#cb10-47"></a>      <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>)</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    ),</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted mean"</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>  )</span>
+<span id="cb10-52"><a href="#cb10-52"></a></span>
+<span id="cb10-53"><a href="#cb10-53"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="at">lyt =</span> l,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="at">df =</span> adqs_multi,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-57"><a href="#cb10-57"></a>)</span>
+<span id="cb10-58"><a href="#cb10-58"></a></span>
+<span id="cb10-59"><a href="#cb10-59"></a>result</span>
+<span id="cb10-60"><a href="#cb10-60"></a><span class="in">```</span></span>
+<span id="cb10-61"><a href="#cb10-61"></a></span>
+<span id="cb10-62"><a href="#cb10-62"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-63"><a href="#cb10-63"></a></span>
+<span id="cb10-64"><a href="#cb10-64"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-65"><a href="#cb10-65"></a></span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a></span>
+<span id="cb10-69"><a href="#cb10-69"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-73"><a href="#cb10-73"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-77"><a href="#cb10-77"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-78"><a href="#cb10-78"></a></span>
+<span id="cb10-79"><a href="#cb10-79"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-82"><a href="#cb10-82"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-83"><a href="#cb10-83"></a>  ),</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-85"><a href="#cb10-85"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-86"><a href="#cb10-86"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-87"><a href="#cb10-87"></a>  )</span>
+<span id="cb10-88"><a href="#cb10-88"></a>)</span>
+<span id="cb10-89"><a href="#cb10-89"></a></span>
+<span id="cb10-90"><a href="#cb10-90"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-91"><a href="#cb10-91"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-92"><a href="#cb10-92"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb10-93"><a href="#cb10-93"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb10-94"><a href="#cb10-94"></a>    <span class="at">code =</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a><span class="st">       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span>,</span>
+<span id="cb10-97"><a href="#cb10-97"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  ),</span>
+<span id="cb10-99"><a href="#cb10-99"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-100"><a href="#cb10-100"></a>    <span class="fu">tm_t_ancova</span>(</span>
+<span id="cb10-101"><a href="#cb10-101"></a>      <span class="at">label =</span> <span class="st">"ANCOVA table"</span>,</span>
+<span id="cb10-102"><a href="#cb10-102"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb10-103"><a href="#cb10-103"></a>      <span class="at">avisit =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-104"><a href="#cb10-104"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"AVISIT"</span>),</span>
+<span id="cb10-105"><a href="#cb10-105"></a>        <span class="at">selected =</span> <span class="st">"WEEK 1 DAY 8"</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a>      ),</span>
+<span id="cb10-107"><a href="#cb10-107"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-108"><a href="#cb10-108"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb10-109"><a href="#cb10-109"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a>      ),</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-113"><a href="#cb10-113"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"CHG"</span>, <span class="st">"AVAL"</span>)),</span>
+<span id="cb10-114"><a href="#cb10-114"></a>        <span class="at">selected =</span> <span class="st">"CHG"</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>      ),</span>
+<span id="cb10-116"><a href="#cb10-116"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-117"><a href="#cb10-117"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb10-118"><a href="#cb10-118"></a>        <span class="at">selected =</span> <span class="st">"STRATA1"</span></span>
+<span id="cb10-119"><a href="#cb10-119"></a>      ),</span>
+<span id="cb10-120"><a href="#cb10-120"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-121"><a href="#cb10-121"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-122"><a href="#cb10-122"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"FKSI-FWB"</span>, <span class="st">"BFIALL"</span>)</span>
+<span id="cb10-123"><a href="#cb10-123"></a>      )</span>
+<span id="cb10-124"><a href="#cb10-124"></a>    )</span>
+<span id="cb10-125"><a href="#cb10-125"></a>  )</span>
+<span id="cb10-126"><a href="#cb10-126"></a>)</span>
+<span id="cb10-127"><a href="#cb10-127"></a></span>
+<span id="cb10-128"><a href="#cb10-128"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-129"><a href="#cb10-129"></a><span class="in">```</span></span>
+<span id="cb10-130"><a href="#cb10-130"></a></span>
+<span id="cb10-131"><a href="#cb10-131"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-132"><a href="#cb10-132"></a></span>
+<span id="cb10-133"><a href="#cb10-133"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
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+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AOVT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ANCOVA with Single End Point and Customized Table</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>This example will focus on data from a single visit “WEEK 1 DAY 8” and a single endpoint “FKSI-FWB”. Only evaluable populations will be analyzed.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aovt02_cache/html/setup_de7206ddfa0caac4f691075c3a8948c8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adqs_single <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(<span class="at">CHG =</span> <span class="fu">ifelse</span>(BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>, CHG, <span class="cn">NA</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aovt02_cache/html/variant1_a3a4be4c1c7dda1abec3d2ae723a899a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">append_varlabels</span>(adqs_single, <span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="cn">NULL</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">var_labels =</span> <span class="st">"Unadjusted comparison"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">lsmean =</span> <span class="st">"Mean"</span>, <span class="at">lsmean_diff =</span> <span class="st">"Difference in Means"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">table_names =</span> <span class="st">"unadjusted"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted comparison (covariates BASE and STRATA1)"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">table_names =</span> <span class="st">"adjusted"</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  )</span>
+<span id="cb2-19"><a href="#cb2-19"></a></span>
+<span id="cb2-20"><a href="#cb2-20"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="at">df =</span> adqs_single,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-24"><a href="#cb2-24"></a>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                            ARM A        ARM B           ARM C    
+                                                    (N=134)      (N=134)         (N=132)   
+———————————————————————————————————————————————————————————————————————————————————————————
+Unadjusted comparison                                                                      
+  n                                                   68           73              62      
+  Mean                                               3.68         5.07            3.09     
+  Difference in Means                                             1.38            -0.59    
+    95% CI                                                    (-2.76, 5.53)   (-4.91, 3.73)
+    p-value                                                      0.5113          0.7873    
+Adjusted comparison (covariates BASE and STRATA1)                                          
+  n                                                   68           73              62      
+  Adjusted Mean                                      4.06         3.57            3.34     
+  Difference in Adjusted Means                                    -0.49           -0.72    
+    95% CI                                                    (-3.28, 2.29)   (-3.57, 2.12)
+    p-value                                                      0.7277          0.6165    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="aovt02_cache/html/teal_f17f64d27612e19da58b6d0c0cd3d32e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="fu">library</span>(tern)</span>
+<span id="cb4-5"><a href="#cb4-5"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb4-9"><a href="#cb4-9"></a></span>
+<span id="cb4-10"><a href="#cb4-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  ),</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb4-22"><a href="#cb4-22"></a>  )</span>
+<span id="cb4-23"><a href="#cb4-23"></a>)</span>
+<span id="cb4-24"><a href="#cb4-24"></a></span>
+<span id="cb4-25"><a href="#cb4-25"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">code =</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a><span class="st">       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a>  ),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="fu">tm_t_ancova</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">label =</span> <span class="st">"ANCOVA table"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb4-38"><a href="#cb4-38"></a>      <span class="at">avisit =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-39"><a href="#cb4-39"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"AVISIT"</span>),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>        <span class="at">selected =</span> <span class="st">"WEEK 1 DAY 8"</span></span>
+<span id="cb4-41"><a href="#cb4-41"></a>      ),</span>
+<span id="cb4-42"><a href="#cb4-42"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-43"><a href="#cb4-43"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb4-44"><a href="#cb4-44"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>      ),</span>
+<span id="cb4-46"><a href="#cb4-46"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb4-47"><a href="#cb4-47"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-48"><a href="#cb4-48"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"CHG"</span>, <span class="st">"AVAL"</span>)),</span>
+<span id="cb4-49"><a href="#cb4-49"></a>        <span class="at">selected =</span> <span class="st">"CHG"</span></span>
+<span id="cb4-50"><a href="#cb4-50"></a>      ),</span>
+<span id="cb4-51"><a href="#cb4-51"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-52"><a href="#cb4-52"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb4-53"><a href="#cb4-53"></a>        <span class="at">selected =</span> <span class="st">"STRATA1"</span></span>
+<span id="cb4-54"><a href="#cb4-54"></a>      ),</span>
+<span id="cb4-55"><a href="#cb4-55"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-56"><a href="#cb4-56"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-57"><a href="#cb4-57"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb4-58"><a href="#cb4-58"></a>      )</span>
+<span id="cb4-59"><a href="#cb4-59"></a>    )</span>
+<span id="cb4-60"><a href="#cb4-60"></a>  )</span>
+<span id="cb4-61"><a href="#cb4-61"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:00:17.7210 pid:7657 token:[] teal.modules.clinical Initializing tm_t_ancova</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="aovt02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aovt02_cache/html/sessioninfo_bdb163e30d4b1945dc9721c123ff016c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aovt02_cache/html/snapshot_355d2c863d8ae120b0671f5a77923bb4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/aovt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+        return popup.innerHTML;
+      });
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+      <a href="../../tables/efficacy/aovt01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AOVT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/aovt03.html" class="pagination-link">
+        <span class="nav-page-text">AOVT03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> AOVT02</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> ANCOVA with Single End Point and Customized Table</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>This example will focus on data from a single visit "WEEK 1 DAY 8" and a single endpoint "FKSI-FWB".</span>
+<span id="cb10-11"><a href="#cb10-11"></a>Only evaluable populations will be analyzed.</span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a>::: panel-tabset</span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a></span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-20"><a href="#cb10-20"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-21"><a href="#cb10-21"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-24"><a href="#cb10-24"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-25"><a href="#cb10-25"></a></span>
+<span id="cb10-26"><a href="#cb10-26"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-28"><a href="#cb10-28"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a>adqs_single <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a>  <span class="fu">mutate</span>(<span class="at">CHG =</span> <span class="fu">ifelse</span>(BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>, CHG, <span class="cn">NA</span>))</span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="in">```</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>  <span class="fu">append_varlabels</span>(adqs_single, <span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="cn">NULL</span>),</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    <span class="at">var_labels =</span> <span class="st">"Unadjusted comparison"</span>,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">lsmean =</span> <span class="st">"Mean"</span>, <span class="at">lsmean_diff =</span> <span class="st">"Difference in Means"</span>),</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">table_names =</span> <span class="st">"unadjusted"</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb10-55"><a href="#cb10-55"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted comparison (covariates BASE and STRATA1)"</span>,</span>
+<span id="cb10-57"><a href="#cb10-57"></a>    <span class="at">table_names =</span> <span class="st">"adjusted"</span></span>
+<span id="cb10-58"><a href="#cb10-58"></a>  )</span>
+<span id="cb10-59"><a href="#cb10-59"></a></span>
+<span id="cb10-60"><a href="#cb10-60"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb10-61"><a href="#cb10-61"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb10-62"><a href="#cb10-62"></a>  <span class="at">df =</span> adqs_single,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-64"><a href="#cb10-64"></a>)</span>
+<span id="cb10-65"><a href="#cb10-65"></a></span>
+<span id="cb10-66"><a href="#cb10-66"></a>result</span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="in">```</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a></span>
+<span id="cb10-69"><a href="#cb10-69"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-70"><a href="#cb10-70"></a></span>
+<span id="cb10-71"><a href="#cb10-71"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a></span>
+<span id="cb10-73"><a href="#cb10-73"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a></span>
+<span id="cb10-76"><a href="#cb10-76"></a><span class="fu">library</span>(teal)</span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-78"><a href="#cb10-78"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-80"><a href="#cb10-80"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-81"><a href="#cb10-81"></a></span>
+<span id="cb10-82"><a href="#cb10-82"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-83"><a href="#cb10-83"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-84"><a href="#cb10-84"></a></span>
+<span id="cb10-85"><a href="#cb10-85"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-87"><a href="#cb10-87"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-88"><a href="#cb10-88"></a></span>
+<span id="cb10-89"><a href="#cb10-89"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-90"><a href="#cb10-90"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-91"><a href="#cb10-91"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-92"><a href="#cb10-92"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-93"><a href="#cb10-93"></a>  ),</span>
+<span id="cb10-94"><a href="#cb10-94"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-95"><a href="#cb10-95"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-96"><a href="#cb10-96"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-97"><a href="#cb10-97"></a>  )</span>
+<span id="cb10-98"><a href="#cb10-98"></a>)</span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-101"><a href="#cb10-101"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-102"><a href="#cb10-102"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl),</span>
+<span id="cb10-103"><a href="#cb10-103"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs),</span>
+<span id="cb10-104"><a href="#cb10-104"></a>    <span class="at">code =</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a>      <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a><span class="st">       ADQS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span>,</span>
+<span id="cb10-107"><a href="#cb10-107"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a>  ),</span>
+<span id="cb10-109"><a href="#cb10-109"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="fu">tm_t_ancova</span>(</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      <span class="at">label =</span> <span class="st">"ANCOVA table"</span>,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb10-113"><a href="#cb10-113"></a>      <span class="at">avisit =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-114"><a href="#cb10-114"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"AVISIT"</span>),</span>
+<span id="cb10-115"><a href="#cb10-115"></a>        <span class="at">selected =</span> <span class="st">"WEEK 1 DAY 8"</span></span>
+<span id="cb10-116"><a href="#cb10-116"></a>      ),</span>
+<span id="cb10-117"><a href="#cb10-117"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-118"><a href="#cb10-118"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb10-119"><a href="#cb10-119"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-120"><a href="#cb10-120"></a>      ),</span>
+<span id="cb10-121"><a href="#cb10-121"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-122"><a href="#cb10-122"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-123"><a href="#cb10-123"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"CHG"</span>, <span class="st">"AVAL"</span>)),</span>
+<span id="cb10-124"><a href="#cb10-124"></a>        <span class="at">selected =</span> <span class="st">"CHG"</span></span>
+<span id="cb10-125"><a href="#cb10-125"></a>      ),</span>
+<span id="cb10-126"><a href="#cb10-126"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-127"><a href="#cb10-127"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>        <span class="at">selected =</span> <span class="st">"STRATA1"</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a>      ),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-131"><a href="#cb10-131"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a>      )</span>
+<span id="cb10-134"><a href="#cb10-134"></a>    )</span>
+<span id="cb10-135"><a href="#cb10-135"></a>  )</span>
+<span id="cb10-136"><a href="#cb10-136"></a>)</span>
+<span id="cb10-137"><a href="#cb10-137"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-138"><a href="#cb10-138"></a><span class="in">```</span></span>
+<span id="cb10-139"><a href="#cb10-139"></a></span>
+<span id="cb10-140"><a href="#cb10-140"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-141"><a href="#cb10-141"></a></span>
+<span id="cb10-142"><a href="#cb10-142"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">AOVT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">ANCOVA with Consideration of Interaction</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>This example will focus on data from multiple visits and take the interaction between visits and arms into consideration.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="aovt03_cache/html/setup_9c211b565a3e024a69e74aadc30e052b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adqs_in <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 5 DAY 36"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BFI All Questions"</span>, <span class="st">"Fatigue Interference"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(<span class="at">CHG =</span> <span class="fu">ifelse</span>(BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>, CHG, <span class="cn">NA</span>)) <span class="co"># only analyze evaluable population</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="aovt03_cache/html/variant1_b3cb82a72f00e59f60f2d2b09b831662">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">build_table</span>(adqs_in, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-32"><a href="#cb2-32"></a></span>
+<span id="cb2-33"><a href="#cb2-33"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    ARM A        ARM B           ARM C    
+                                   (N=134)      (N=134)         (N=132)   
+——————————————————————————————————————————————————————————————————————————
+BFI All Questions                                                         
+  WEEK 1 DAY 8                                                            
+    n                                68           73              62      
+    Adjusted Mean                   4.34         5.96            3.90     
+    Difference in Adjusted Means                 1.62            -0.44    
+      95% CI                                 (-1.75, 4.98)   (-3.94, 3.06)
+      p-value                                   0.3460          0.8059    
+  WEEK 2 DAY 15                                                           
+    n                                68           73              62      
+    Adjusted Mean                   12.99        11.23           9.86     
+    Difference in Adjusted Means                 -1.76           -3.13    
+      95% CI                                 (-5.12, 1.60)   (-6.64, 0.37)
+      p-value                                   0.3048          0.0795    
+  WEEK 5 DAY 36                                                           
+    n                                68           73              62      
+    Adjusted Mean                   23.88        23.08           28.21    
+    Difference in Adjusted Means                 -0.81           4.33     
+      95% CI                                 (-4.17, 2.56)   (0.83, 7.83) 
+      p-value                                   0.6383          0.0155    
+Fatigue Interference                                                      
+  WEEK 1 DAY 8                                                            
+    n                                68           73              62      
+    Adjusted Mean                   5.97         5.19            5.21     
+    Difference in Adjusted Means                 -0.78           -0.76    
+      95% CI                                 (-4.17, 2.61)   (-4.30, 2.78)
+      p-value                                   0.6522          0.6729    
+  WEEK 2 DAY 15                                                           
+    n                                68           73              62      
+    Adjusted Mean                   11.39        9.42            9.55     
+    Difference in Adjusted Means                 -1.96           -1.84    
+      95% CI                                 (-5.35, 1.43)   (-5.37, 1.70)
+      p-value                                   0.2560          0.3084    
+  WEEK 5 DAY 36                                                           
+    n                                68           73              62      
+    Adjusted Mean                   22.79        25.37           23.43    
+    Difference in Adjusted Means                 2.58            0.64     
+      95% CI                                 (-0.81, 5.97)   (-2.89, 4.18)
+      p-value                                   0.1353          0.7212    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="aovt03_cache/html/teal_5dc5e32ecf2ad17624d73dd5455fbee8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="aovt03_cache/html/sessioninfo_8adfc058383849df3d20068f0ab87e5f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] sandwich_3.0-2     utf8_1.2.3         generics_0.1.3     tidyr_1.3.0       
+ [5] lattice_0.21-8     digest_0.6.33      evaluate_0.21      grid_4.3.1        
+ [9] estimability_1.4.1 mvtnorm_1.2-3      fastmap_1.1.1      jsonlite_1.8.7    
+[13] Matrix_1.6-1.1     backports_1.4.1    brio_1.1.3         survival_3.5-7    
+[17] multcomp_1.4-25    purrr_1.0.2        fansi_1.0.4        scales_1.2.1      
+[21] TH.data_1.1-2      codetools_0.2-19   Rdpack_2.5         cli_3.6.1         
+[25] rlang_1.1.1        rbibutils_2.2.15   munsell_0.5.0      splines_4.3.1     
+[29] yaml_2.3.7         tools_4.3.1        checkmate_2.2.0    coda_0.19-4       
+[33] colorspace_2.1-0   ggplot2_3.4.3      broom_1.0.5        vctrs_0.6.3       
+[37] R6_2.5.1           zoo_1.8-12         lifecycle_1.0.3    emmeans_1.8.8     
+[41] htmlwidgets_1.6.2  MASS_7.3-60        pkgconfig_2.0.3    pillar_1.9.0      
+[45] gtable_0.3.4       glue_1.6.2         xfun_0.40          tibble_3.2.1      
+[49] tidyselect_1.2.0   rstudioapi_0.15.0  knitr_1.44         xtable_1.8-4      
+[53] htmltools_0.5.6    rmarkdown_2.25     testthat_3.1.10    compiler_4.3.1    </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="aovt03_cache/html/snapshot_b44dc15086a52e6cc9a4d6372c6ef4b1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/aovt03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
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+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/efficacy/aovt02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">AOVT02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/cfbt01.html" class="pagination-link">
+        <span class="nav-page-text">CFBT01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> AOVT03</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> ANCOVA with Consideration of Interaction</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>This example will focus on data from multiple visits and take the interaction between visits and arms into consideration.</span>
+<span id="cb8-11"><a href="#cb8-11"></a></span>
+<span id="cb8-12"><a href="#cb8-12"></a>::: panel-tabset</span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a></span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-23"><a href="#cb8-23"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a>adqs_in <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 5 DAY 36"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">filter</span>(PARAM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BFI All Questions"</span>, <span class="st">"Fatigue Interference"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">mutate</span>(<span class="at">CHG =</span> <span class="fu">ifelse</span>(BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>, CHG, <span class="cn">NA</span>)) <span class="co"># only analyze evaluable population</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="in">```</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a></span>
+<span id="cb8-32"><a href="#cb8-32"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels) <span class="sc">%&gt;%</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 1 DAY 8"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb8-53"><a href="#cb8-53"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 2 DAY 15"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="fu">summarize_ancova</span>(</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">vars =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AVISIT"</span>, <span class="st">"AVISIT*ARMCD"</span>)),</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">var_labels =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>    <span class="at">table_names =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    <span class="at">interaction_y =</span> <span class="st">"WEEK 5 DAY 36"</span>,</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    <span class="at">interaction_item =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="fu">build_table</span>(adqs_in, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a>result</span>
+<span id="cb8-68"><a href="#cb8-68"></a><span class="in">```</span></span>
+<span id="cb8-69"><a href="#cb8-69"></a></span>
+<span id="cb8-70"><a href="#cb8-70"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-71"><a href="#cb8-71"></a></span>
+<span id="cb8-72"><a href="#cb8-72"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a></span>
+<span id="cb8-74"><a href="#cb8-74"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="co"># In progress</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a><span class="in">```</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a></span>
+<span id="cb8-80"><a href="#cb8-80"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-81"><a href="#cb8-81"></a></span>
+<span id="cb8-82"><a href="#cb8-82"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CFBT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Efficacy Data and Change from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cfbt01_cache/html/setup_9e2666571f6c7d009b4c1a9a61bf4bea">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># This example focuses on "BFI All Questions" starting from baseline.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adqs <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAM <span class="sc">==</span> <span class="st">"BFI All Questions"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  )</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a><span class="co"># Define the split function for AVISIT</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cfbt01_cache/html/variant1_f2b6114ff8bec7ab99242109af4bb362">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  } <span class="cf">else</span> {</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  }</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  )</span>
+<span id="cb2-24"><a href="#cb2-24"></a>}</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-28"><a href="#cb2-28"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs<span class="sc">$</span>PARAM)</span>
+<span id="cb2-33"><a href="#cb2-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-34"><a href="#cb2-34"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs<span class="sc">$</span>AVISIT)</span>
+<span id="cb2-39"><a href="#cb2-39"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb2-43"><a href="#cb2-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb2-45"><a href="#cb2-45"></a></span>
+<span id="cb2-46"><a href="#cb2-46"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adqs)</span>
+<span id="cb2-47"><a href="#cb2-47"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                      A: Drug X                        B: Placebo                      C: Combination         
+  Analysis Visit                      Change from                       Change from                       Change from  
+                    Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+BFI All Questions                                                                                                      
+  BASELINE                                                                                                             
+    n                    134                               134                               132                       
+    Mean (SD)        49.93 (7.44)                      49.74 (8.29)                      50.30 (9.06)                  
+    Median              48.69                             49.28                             49.74                      
+    Min - Max       33.72 - 65.91                     25.82 - 71.47                     26.04 - 69.99                  
+  WEEK 1 DAY 8                                                                                                         
+    n                    134              134              134              134              132              132      
+    Mean (SD)        54.51 (8.61)     4.58 (11.23)     56.33 (7.86)     6.59 (11.81)     54.03 (8.31)     3.72 (12.66) 
+    Median              55.15             5.47            56.39             6.96            53.76             3.71     
+    Min - Max       34.26 - 75.42    -25.52 - 29.68   36.82 - 74.45    -25.10 - 31.05   26.89 - 75.95    -26.81 - 33.75
+  WEEK 2 DAY 15                                                                                                        
+    n                    134              134              134              134              132              132      
+    Mean (SD)       60.98 (10.31)    11.05 (12.46)     59.68 (9.59)     9.94 (12.84)     60.11 (8.76)     9.80 (12.59) 
+    Median              60.60            10.45            58.18             8.95            61.08            10.04     
+    Min - Max       35.94 - 96.53    -14.02 - 45.01   40.44 - 84.70    -17.59 - 40.52   32.76 - 78.25    -26.57 - 39.56
+  WEEK 3 DAY 22                                                                                                        
+    n                    134              134              134              134              132              132      
+    Mean (SD)        64.64 (9.88)    14.72 (11.99)    65.78 (10.17)    16.04 (13.80)    63.65 (10.50)    13.35 (13.39) 
+    Median              65.21            15.10            66.28            15.49            63.79            12.24     
+    Min - Max       40.49 - 95.35    -16.76 - 43.40   42.16 - 92.32    -17.70 - 46.85   29.29 - 88.41    -22.40 - 39.94
+  WEEK 4 DAY 29                                                                                                        
+    n                    134              134              134              134              132              132      
+    Mean (SD)       69.43 (11.12)    19.51 (13.83)    69.79 (11.46)    20.05 (14.38)    70.68 (10.23)    20.37 (12.99) 
+    Median              69.22            19.90            70.37            20.99            70.85            20.94     
+    Min - Max       38.38 - 95.48    -17.34 - 49.18   45.79 - 93.33    -19.66 - 58.05   30.53 - 90.61    -14.01 - 60.23
+  WEEK 5 DAY 36                                                                                                        
+    n                    134              134              134              134              132              132      
+    Mean (SD)       74.31 (12.44)    24.38 (14.75)    74.73 (12.96)    24.99 (14.67)    75.89 (13.54)    25.59 (17.18) 
+    Median              76.12            25.20            74.13            22.81            76.70            25.32     
+    Min - Max       39.45 - 103.92   -7.53 - 56.23    38.19 - 109.61   -18.42 - 64.15   43.79 - 102.40   -16.11 - 67.78</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:18}" data-hash="cfbt01_cache/html/teal_227b9e7c6325b223168f91fabda817f8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>      adsl,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>      <span class="at">code =</span> <span class="st">'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>    ),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      adqs,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="at">code =</span> <span class="st">'adqs &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>    ),</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a>  ),</span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">label =</span> <span class="st">"Efficacy Data and Change from Baseline by Visit"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-29"><a href="#cb4-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-30"><a href="#cb4-30"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>      ),</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-33"><a href="#cb4-33"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      ),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-37"><a href="#cb4-37"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb4-38"><a href="#cb4-38"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb4-39"><a href="#cb4-39"></a>      ),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>        <span class="at">selected =</span> <span class="st">"BFIALL"</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>      ),</span>
+<span id="cb4-45"><a href="#cb4-45"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>    )</span>
+<span id="cb4-48"><a href="#cb4-48"></a>  ),</span>
+<span id="cb4-49"><a href="#cb4-49"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADQS =</span> <span class="fu">list</span>(<span class="at">AVISIT =</span> <span class="fu">list</span>(), <span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb4-50"><a href="#cb4-50"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:00:58.1333 pid:7755 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cfbt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cfbt01_cache/html/sessioninfo_53e4371f5a4ad4b36cd7dbd464b2d91b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cfbt01_cache/html/snapshot_7c5c60974dadbe323d335d95b0ea702e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/cfbt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
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+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
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+  const enableStylesheet = (stylesheets) => {
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+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
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+      } else {
+        el.classList.add('notransition');
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+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
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+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
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+    }
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+  const setStyleSentinel = (alternate) => {
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+    if (!isFileUrl()) {
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+    } else {
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+    }
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+  // Dark / light mode switch
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+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
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+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
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+        } else {
+          details.removeAttribute("open");
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+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
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+  if (hideAllCode) {
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+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
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+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
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+      interactiveBorder: 10,
+      theme: 'quarto',
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+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
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+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
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+        })
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+        let height = null;
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+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
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+              div.setAttribute("id", "code-annotation-line-highlight");
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+            div.style.height = height + 4 + "px";
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+              gutterDiv.style.position = 'absolute';
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+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
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+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
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+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
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+  }
+});
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> CFBT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Efficacy Data and Change from Baseline by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="co"># This example focuses on "BFI All Questions" starting from baseline.</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>adqs <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    PARAM <span class="sc">==</span> <span class="st">"BFI All Questions"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  )</span>
+<span id="cb10-33"><a href="#cb10-33"></a></span>
+<span id="cb10-34"><a href="#cb10-34"></a><span class="co"># Define the split function for AVISIT</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="in">```</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb10-42"><a href="#cb10-42"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-43"><a href="#cb10-43"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-47"><a href="#cb10-47"></a>  } <span class="cf">else</span> {</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  }</span>
+<span id="cb10-52"><a href="#cb10-52"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb10-57"><a href="#cb10-57"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb10-63"><a href="#cb10-63"></a>  )</span>
+<span id="cb10-64"><a href="#cb10-64"></a>}</span>
+<span id="cb10-65"><a href="#cb10-65"></a></span>
+<span id="cb10-66"><a href="#cb10-66"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-69"><a href="#cb10-69"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb10-70"><a href="#cb10-70"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-71"><a href="#cb10-71"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-72"><a href="#cb10-72"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs<span class="sc">$</span>PARAM)</span>
+<span id="cb10-73"><a href="#cb10-73"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-75"><a href="#cb10-75"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb10-76"><a href="#cb10-76"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adqs<span class="sc">$</span>AVISIT)</span>
+<span id="cb10-79"><a href="#cb10-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb10-82"><a href="#cb10-82"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb10-83"><a href="#cb10-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb10-85"><a href="#cb10-85"></a></span>
+<span id="cb10-86"><a href="#cb10-86"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adqs)</span>
+<span id="cb10-87"><a href="#cb10-87"></a>result</span>
+<span id="cb10-88"><a href="#cb10-88"></a><span class="in">```</span></span>
+<span id="cb10-89"><a href="#cb10-89"></a></span>
+<span id="cb10-90"><a href="#cb10-90"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-93"><a href="#cb10-93"></a></span>
+<span id="cb10-94"><a href="#cb10-94"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a><span class="co">#| screenshot.opts = list(delay = 18)</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-100"><a href="#cb10-100"></a></span>
+<span id="cb10-101"><a href="#cb10-101"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-102"><a href="#cb10-102"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb10-103"><a href="#cb10-103"></a></span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-106"><a href="#cb10-106"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb10-107"><a href="#cb10-107"></a></span>
+<span id="cb10-108"><a href="#cb10-108"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-109"><a href="#cb10-109"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      adsl,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">code =</span> <span class="st">'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb10-113"><a href="#cb10-113"></a>    ),</span>
+<span id="cb10-114"><a href="#cb10-114"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>,</span>
+<span id="cb10-115"><a href="#cb10-115"></a>      adqs,</span>
+<span id="cb10-116"><a href="#cb10-116"></a>      <span class="at">code =</span> <span class="st">'adqs &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adqs"))'</span></span>
+<span id="cb10-117"><a href="#cb10-117"></a>    ),</span>
+<span id="cb10-118"><a href="#cb10-118"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-119"><a href="#cb10-119"></a>  ),</span>
+<span id="cb10-120"><a href="#cb10-120"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-121"><a href="#cb10-121"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-122"><a href="#cb10-122"></a>      <span class="at">label =</span> <span class="st">"Efficacy Data and Change from Baseline by Visit"</span>,</span>
+<span id="cb10-123"><a href="#cb10-123"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb10-124"><a href="#cb10-124"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-125"><a href="#cb10-125"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-126"><a href="#cb10-126"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a>      ),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-129"><a href="#cb10-129"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb10-131"><a href="#cb10-131"></a>      ),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-133"><a href="#cb10-133"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adqs, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb10-134"><a href="#cb10-134"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb10-135"><a href="#cb10-135"></a>      ),</span>
+<span id="cb10-136"><a href="#cb10-136"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-137"><a href="#cb10-137"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-138"><a href="#cb10-138"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-139"><a href="#cb10-139"></a>        <span class="at">selected =</span> <span class="st">"BFIALL"</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a>      ),</span>
+<span id="cb10-141"><a href="#cb10-141"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-142"><a href="#cb10-142"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-143"><a href="#cb10-143"></a>    )</span>
+<span id="cb10-144"><a href="#cb10-144"></a>  ),</span>
+<span id="cb10-145"><a href="#cb10-145"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADQS =</span> <span class="fu">list</span>(<span class="at">AVISIT =</span> <span class="fu">list</span>(), <span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb10-146"><a href="#cb10-146"></a>)</span>
+<span id="cb10-147"><a href="#cb10-147"></a></span>
+<span id="cb10-148"><a href="#cb10-148"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-149"><a href="#cb10-149"></a><span class="in">```</span></span>
+<span id="cb10-150"><a href="#cb10-150"></a></span>
+<span id="cb10-151"><a href="#cb10-151"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-152"><a href="#cb10-152"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">CMHT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Cochran-Mantel-Haenszel (CMH) Summary</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Table of Single Parameter</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table of Multiple Parameters</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="cmht01_cache/html/setup_9fe9a017c9a1076201f81d2699e35451">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="cmht01_cache/html/variant1_199393ef191bb7c3617896e12774297a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>anl_01 <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> PCHG <span class="sc">&gt;</span> <span class="dv">15</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">mutate</span>(<span class="at">strata =</span> <span class="fu">interaction</span>(STRATA1, STRATA2, <span class="at">drop =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>lyt_01 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">estimate_proportion</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">test_proportion_diff</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"test_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">estimate_odds_ratio</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_or"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-27"><a href="#cb2-27"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  )</span>
+<span id="cb2-38"><a href="#cb2-38"></a></span>
+<span id="cb2-39"><a href="#cb2-39"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-40"><a href="#cb2-40"></a>  <span class="at">lyt =</span> lyt_01,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>  <span class="at">df =</span> anl_01,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-43"><a href="#cb2-43"></a>)</span>
+<span id="cb2-44"><a href="#cb2-44"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                            A: Drug X         B: Placebo         C: Combination  
+                                             (N=134)           (N=134)              (N=132)      
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Responders                                  49 (36.6%)        51 (38.1%)           47 (35.6%)    
+95% CI (Wald, with correction)             (28.0, 45.1)      (29.5, 46.7)         (27.1, 44.2)   
+Unstratified Analysis                                                                            
+  Difference in Response rate (%)                                1.5                  -1.0       
+    95% CI (Wald, with correction)                          (-10.8, 13.8)        (-13.3, 11.3)   
+  p-value (Chi-Squared Test)                                    0.8006               0.8704      
+Odds Ratio (95% CI)                                       1.07 (0.65 - 1.75)   0.96 (0.58 - 1.58)
+Stratified Analysis                                                                              
+  Difference in Response rate (%)                                2.8                  -1.5       
+    95% CI (CMH, without correction)                         (-8.2, 13.8)         (-13.0, 9.9)   
+  p-value (Cochran-Mantel-Haenszel Test)                        0.6397               0.7952      
+Odds Ratio (95% CI)                                       1.12 (0.68 - 1.83)   0.99 (0.60 - 1.64)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="cmht01_cache/html/variant2_626f78ef368f3169fc26ce354af1ec35">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>anl_02 <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> PCHG <span class="sc">&gt;</span> <span class="dv">15</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">droplevels</span>(PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">mutate</span>(<span class="at">strata =</span> <span class="fu">interaction</span>(STRATA1, STRATA2, <span class="at">drop =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a><span class="fu">var_labels</span>(anl_02)[<span class="st">"PARAM"</span>] <span class="ot">&lt;-</span> <span class="st">"Parameter"</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>lyt_02 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">var =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(anl_02<span class="sc">$</span>PARAM)</span>
+<span id="cb4-20"><a href="#cb4-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">estimate_proportion</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">test_proportion_diff</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"test_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  <span class="fu">estimate_odds_ratio</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_or"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb4-42"><a href="#cb4-42"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb4-47"><a href="#cb4-47"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  )</span>
+<span id="cb4-49"><a href="#cb4-49"></a></span>
+<span id="cb4-50"><a href="#cb4-50"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-51"><a href="#cb4-51"></a>  <span class="at">lyt =</span> lyt_02,</span>
+<span id="cb4-52"><a href="#cb4-52"></a>  <span class="at">df =</span> anl_02,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-54"><a href="#cb4-54"></a>)</span>
+<span id="cb4-55"><a href="#cb4-55"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                     A: Drug X         B: Placebo         C: Combination  
+                                               (N=134)           (N=134)              (N=132)      
+———————————————————————————————————————————————————————————————————————————————————————————————————
+BFI All Questions                                                                                  
+  Responders                                  57 (42.5%)        65 (48.5%)           50 (37.9%)    
+  95% CI (Wald, with correction)             (33.8, 51.3)      (39.7, 57.3)         (29.2, 46.5)   
+  Unstratified Analysis                                                                            
+    Difference in Response rate (%)                                6.0                  -4.7       
+      95% CI (Wald, with correction)                           (-6.7, 18.6)         (-17.2, 7.9)   
+    p-value (Chi-Squared Test)                                    0.3264               0.4385      
+  Odds Ratio (95% CI)                                       1.27 (0.79 - 2.06)   0.82 (0.50 - 1.35)
+  Stratified Analysis                                                                              
+    Difference in Response rate (%)                                6.7                  -5.1       
+      95% CI (CMH, without correction)                         (-5.0, 18.4)         (-16.8, 6.6)   
+    p-value (Cochran-Mantel-Haenszel Test)                        0.2781               0.4056      
+  Odds Ratio (95% CI)                                       1.30 (0.80 - 2.11)   0.80 (0.49 - 1.32)
+Fatigue Interference                                                                               
+  Responders                                  66 (49.3%)        50 (37.3%)           48 (36.4%)    
+  95% CI (Wald, with correction)             (40.4, 58.1)      (28.8, 45.9)         (27.8, 44.9)   
+  Unstratified Analysis                                                                            
+    Difference in Response rate (%)                               -11.9                -12.9       
+      95% CI (Wald, with correction)                           (-24.5, 0.6)        (-25.4, -0.3)   
+    p-value (Chi-Squared Test)                                    0.0485               0.0337      
+  Odds Ratio (95% CI)                                       0.61 (0.38 - 1.00)   0.59 (0.36 - 0.96)
+  Stratified Analysis                                                                              
+    Difference in Response rate (%)                               -12.0                -13.3       
+      95% CI (CMH, without correction)                        (-23.7, -0.2)        (-24.9, -1.6)   
+    p-value (Cochran-Mantel-Haenszel Test)                        0.0518               0.0303      
+  Odds Ratio (95% CI)                                       0.61 (0.37 - 0.99)   0.58 (0.36 - 0.96)
+FKSI-19 All Questions                                                                              
+  Responders                                  60 (44.8%)        57 (42.5%)           68 (51.5%)    
+  95% CI (Wald, with correction)             (36.0, 53.6)      (33.8, 51.3)         (42.6, 60.4)   
+  Unstratified Analysis                                                                            
+    Difference in Response rate (%)                                -2.2                 6.7        
+      95% CI (Wald, with correction)                          (-14.9, 10.4)         (-6.0, 19.5)   
+    p-value (Chi-Squared Test)                                    0.7118               0.2714      
+  Odds Ratio (95% CI)                                       0.91 (0.56 - 1.48)   1.31 (0.81 - 2.12)
+  Stratified Analysis                                                                              
+    Difference in Response rate (%)                                -2.8                 5.6        
+      95% CI (CMH, without correction)                         (-14.3, 8.8)         (-6.2, 17.4)   
+    p-value (Cochran-Mantel-Haenszel Test)                        0.6442               0.3683      
+  Odds Ratio (95% CI)                                       0.90 (0.56 - 1.47)   1.26 (0.77 - 2.04)
+Function/Well-Being (GF1,GF3,GF7)                                                                  
+  Responders                                  49 (36.6%)        51 (38.1%)           47 (35.6%)    
+  95% CI (Wald, with correction)             (28.0, 45.1)      (29.5, 46.7)         (27.1, 44.2)   
+  Unstratified Analysis                                                                            
+    Difference in Response rate (%)                                1.5                  -1.0       
+      95% CI (Wald, with correction)                          (-10.8, 13.8)        (-13.3, 11.3)   
+    p-value (Chi-Squared Test)                                    0.8006               0.8704      
+  Odds Ratio (95% CI)                                       1.07 (0.65 - 1.75)   0.96 (0.58 - 1.58)
+  Stratified Analysis                                                                              
+    Difference in Response rate (%)                                2.8                  -1.5       
+      95% CI (CMH, without correction)                         (-8.2, 13.8)         (-13.0, 9.9)   
+    p-value (Cochran-Mantel-Haenszel Test)                        0.6397               0.7952      
+  Odds Ratio (95% CI)                                       1.12 (0.68 - 1.83)   0.99 (0.60 - 1.64)
+Treatment Side Effects (GP2,C5,GP5)                                                                
+  Responders                                  62 (46.3%)        49 (36.6%)           51 (38.6%)    
+  95% CI (Wald, with correction)             (37.5, 55.1)      (28.0, 45.1)         (30.0, 47.3)   
+  Unstratified Analysis                                                                            
+    Difference in Response rate (%)                                -9.7                 -7.6       
+      95% CI (Wald, with correction)                           (-22.2, 2.8)         (-20.2, 5.0)   
+    p-value (Chi-Squared Test)                                    0.1069               0.2080      
+  Odds Ratio (95% CI)                                       0.67 (0.41 - 1.09)   0.73 (0.45 - 1.19)
+  Stratified Analysis                                                                              
+    Difference in Response rate (%)                                -9.6                 -7.1       
+      95% CI (CMH, without correction)                         (-21.0, 1.8)         (-18.8, 4.6)   
+    p-value (Cochran-Mantel-Haenszel Test)                        0.1168               0.2426      
+  Odds Ratio (95% CI)                                       0.67 (0.41 - 1.10)   0.73 (0.45 - 1.19)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:18}" data-hash="cmht01_cache/html/teal_14c9d3b79debd15d97d8c91f69ac4239">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(<span class="at">ref =</span> <span class="st">"ARM B"</span>, <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(<span class="at">ref =</span> <span class="st">"B: Placebo"</span>, <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))</span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span>
+<span id="cb6-12"><a href="#cb6-12"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, ADRS),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">code =</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a><span class="st">    ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs")'</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  ),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="fu">tm_t_binary_outcome</span>(</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      <span class="at">label =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>      ),</span>
+<span id="cb6-28"><a href="#cb6-28"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-29"><a href="#cb6-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb6-30"><a href="#cb6-30"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>      ),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>        <span class="at">select =</span> <span class="cn">NULL</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>      )</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    )</span>
+<span id="cb6-38"><a href="#cb6-38"></a>  )</span>
+<span id="cb6-39"><a href="#cb6-39"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:02:37.5383 pid:7953 token:[] teal.modules.clinical Initializing tm_t_binary_outcome</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="cmht01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="cmht01_cache/html/sessioninfo_92dbd0e83b75c4d5db1158d439b338fd">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="cmht01_cache/html/snapshot_d1dc496d680343fcdf8242090b5cac0b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/cmht01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> CMHT01</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Cochran-Mantel-Haenszel (CMH) Summary</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb12-26"><a href="#cb12-26"></a><span class="in">```</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="fu">## Table of Single Parameter</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a></span>
+<span id="cb12-30"><a href="#cb12-30"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>anl_01 <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> PCHG <span class="sc">&gt;</span> <span class="dv">15</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a>  <span class="fu">mutate</span>(<span class="at">strata =</span> <span class="fu">interaction</span>(STRATA1, STRATA2, <span class="at">drop =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb12-37"><a href="#cb12-37"></a></span>
+<span id="cb12-38"><a href="#cb12-38"></a>lyt_01 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>  <span class="fu">estimate_proportion</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb12-42"><a href="#cb12-42"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb12-43"><a href="#cb12-43"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-44"><a href="#cb12-44"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-45"><a href="#cb12-45"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>  <span class="fu">test_proportion_diff</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"test_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-48"><a href="#cb12-48"></a>  <span class="fu">estimate_odds_ratio</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_or"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb12-51"><a href="#cb12-51"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-52"><a href="#cb12-52"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-53"><a href="#cb12-53"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb12-54"><a href="#cb12-54"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb12-55"><a href="#cb12-55"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb12-58"><a href="#cb12-58"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-59"><a href="#cb12-59"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb12-60"><a href="#cb12-60"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb12-61"><a href="#cb12-61"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-63"><a href="#cb12-63"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb12-64"><a href="#cb12-64"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-65"><a href="#cb12-65"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb12-66"><a href="#cb12-66"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb12-67"><a href="#cb12-67"></a>  )</span>
+<span id="cb12-68"><a href="#cb12-68"></a></span>
+<span id="cb12-69"><a href="#cb12-69"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-70"><a href="#cb12-70"></a>  <span class="at">lyt =</span> lyt_01,</span>
+<span id="cb12-71"><a href="#cb12-71"></a>  <span class="at">df =</span> anl_01,</span>
+<span id="cb12-72"><a href="#cb12-72"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-73"><a href="#cb12-73"></a>)</span>
+<span id="cb12-74"><a href="#cb12-74"></a>result</span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="in">```</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a></span>
+<span id="cb12-77"><a href="#cb12-77"></a><span class="fu">## Table of Multiple Parameters</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a></span>
+<span id="cb12-79"><a href="#cb12-79"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-80"><a href="#cb12-80"></a>anl_02 <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb12-81"><a href="#cb12-81"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> PCHG <span class="sc">&gt;</span> <span class="dv">15</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">droplevels</span>(PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-84"><a href="#cb12-84"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-85"><a href="#cb12-85"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-86"><a href="#cb12-86"></a>  <span class="fu">mutate</span>(<span class="at">strata =</span> <span class="fu">interaction</span>(STRATA1, STRATA2, <span class="at">drop =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb12-87"><a href="#cb12-87"></a></span>
+<span id="cb12-88"><a href="#cb12-88"></a><span class="fu">var_labels</span>(anl_02)[<span class="st">"PARAM"</span>] <span class="ot">&lt;-</span> <span class="st">"Parameter"</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a></span>
+<span id="cb12-90"><a href="#cb12-90"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-91"><a href="#cb12-91"></a></span>
+<span id="cb12-92"><a href="#cb12-92"></a>lyt_02 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-95"><a href="#cb12-95"></a>    <span class="at">var =</span> <span class="st">"PARAM"</span>,</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-97"><a href="#cb12-97"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-98"><a href="#cb12-98"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(anl_02<span class="sc">$</span>PARAM)</span>
+<span id="cb12-99"><a href="#cb12-99"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a>  <span class="fu">estimate_proportion</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-101"><a href="#cb12-101"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb12-102"><a href="#cb12-102"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb12-103"><a href="#cb12-103"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-104"><a href="#cb12-104"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-105"><a href="#cb12-105"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb12-106"><a href="#cb12-106"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-107"><a href="#cb12-107"></a>  <span class="fu">test_proportion_diff</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"test_prop"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-108"><a href="#cb12-108"></a>  <span class="fu">estimate_odds_ratio</span>(<span class="at">vars =</span> <span class="st">"is_rsp"</span>, <span class="at">table_names =</span> <span class="st">"est_or"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-109"><a href="#cb12-109"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb12-110"><a href="#cb12-110"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb12-111"><a href="#cb12-111"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-112"><a href="#cb12-112"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-113"><a href="#cb12-113"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb12-114"><a href="#cb12-114"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb12-115"><a href="#cb12-115"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb12-116"><a href="#cb12-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb12-118"><a href="#cb12-118"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-119"><a href="#cb12-119"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb12-120"><a href="#cb12-120"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>),</span>
+<span id="cb12-121"><a href="#cb12-121"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb12-122"><a href="#cb12-122"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-123"><a href="#cb12-123"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb12-124"><a href="#cb12-124"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb12-125"><a href="#cb12-125"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> <span class="st">"strata"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb12-126"><a href="#cb12-126"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb12-127"><a href="#cb12-127"></a>  )</span>
+<span id="cb12-128"><a href="#cb12-128"></a></span>
+<span id="cb12-129"><a href="#cb12-129"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-130"><a href="#cb12-130"></a>  <span class="at">lyt =</span> lyt_02,</span>
+<span id="cb12-131"><a href="#cb12-131"></a>  <span class="at">df =</span> anl_02,</span>
+<span id="cb12-132"><a href="#cb12-132"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-133"><a href="#cb12-133"></a>)</span>
+<span id="cb12-134"><a href="#cb12-134"></a>result</span>
+<span id="cb12-135"><a href="#cb12-135"></a><span class="in">```</span></span>
+<span id="cb12-136"><a href="#cb12-136"></a></span>
+<span id="cb12-137"><a href="#cb12-137"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-138"><a href="#cb12-138"></a></span>
+<span id="cb12-139"><a href="#cb12-139"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-140"><a href="#cb12-140"></a></span>
+<span id="cb12-141"><a href="#cb12-141"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-142"><a href="#cb12-142"></a><span class="co">#| screenshot.opts = list(delay = 18)</span></span>
+<span id="cb12-143"><a href="#cb12-143"></a></span>
+<span id="cb12-144"><a href="#cb12-144"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-145"><a href="#cb12-145"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-146"><a href="#cb12-146"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-147"><a href="#cb12-147"></a></span>
+<span id="cb12-148"><a href="#cb12-148"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-149"><a href="#cb12-149"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb12-150"><a href="#cb12-150"></a></span>
+<span id="cb12-151"><a href="#cb12-151"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb12-152"><a href="#cb12-152"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(<span class="at">ref =</span> <span class="st">"ARM B"</span>, <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)),</span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(<span class="at">ref =</span> <span class="st">"B: Placebo"</span>, <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>))</span>
+<span id="cb12-154"><a href="#cb12-154"></a>)</span>
+<span id="cb12-155"><a href="#cb12-155"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-156"><a href="#cb12-156"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-157"><a href="#cb12-157"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL),</span>
+<span id="cb12-158"><a href="#cb12-158"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, ADRS),</span>
+<span id="cb12-159"><a href="#cb12-159"></a>    <span class="at">code =</span></span>
+<span id="cb12-160"><a href="#cb12-160"></a>      <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a><span class="st">    ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs")'</span></span>
+<span id="cb12-162"><a href="#cb12-162"></a>  ),</span>
+<span id="cb12-163"><a href="#cb12-163"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-164"><a href="#cb12-164"></a>    <span class="fu">tm_t_binary_outcome</span>(</span>
+<span id="cb12-165"><a href="#cb12-165"></a>      <span class="at">label =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb12-166"><a href="#cb12-166"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb12-167"><a href="#cb12-167"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-168"><a href="#cb12-168"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-169"><a href="#cb12-169"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb12-170"><a href="#cb12-170"></a>      ),</span>
+<span id="cb12-171"><a href="#cb12-171"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-172"><a href="#cb12-172"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb12-173"><a href="#cb12-173"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-174"><a href="#cb12-174"></a>      ),</span>
+<span id="cb12-175"><a href="#cb12-175"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb12-176"><a href="#cb12-176"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-177"><a href="#cb12-177"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb12-178"><a href="#cb12-178"></a>        <span class="at">select =</span> <span class="cn">NULL</span></span>
+<span id="cb12-179"><a href="#cb12-179"></a>      )</span>
+<span id="cb12-180"><a href="#cb12-180"></a>    )</span>
+<span id="cb12-181"><a href="#cb12-181"></a>  )</span>
+<span id="cb12-182"><a href="#cb12-182"></a>)</span>
+<span id="cb12-183"><a href="#cb12-183"></a></span>
+<span id="cb12-184"><a href="#cb12-184"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-185"><a href="#cb12-185"></a><span class="in">```</span></span>
+<span id="cb12-186"><a href="#cb12-186"></a></span>
+<span id="cb12-187"><a href="#cb12-187"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-188"><a href="#cb12-188"></a></span>
+<span id="cb12-189"><a href="#cb12-189"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
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+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">COXT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Cox Regression</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>Cox models are the most commonly used methods to estimate the magnitude of the effect in survival analyses. It assumes proportional hazards; that is, it assumes that the ratio of the hazards of the two groups (e.g.&nbsp;two arms) is constant over time. This ratio is referred to as the “hazard ratio” and is one of the most commonly reported metrics to describe the effect size in survival analysis.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Cox Regression</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Cox Regression <br> with Interaction Term</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Cox Regression <br> Specifying Covariates</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Cox Regression Setting <br> Strata, Ties, Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="coxt01_cache/html/setup_007f5336334544d9b73d0f8248a95dea">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl_filtered <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  RACE <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>, <span class="st">"WHITE"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>adtte_filtered <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">inner_join</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">x =</span> adsl_filtered[, <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)],</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">y =</span> adtte,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>anl <span class="ot">&lt;-</span> adtte_filtered <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">mutate</span>(<span class="at">EVENT =</span> <span class="dv">1</span> <span class="sc">-</span> CNSR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(<span class="fu">relevel</span>(ARM, <span class="st">"B: Placebo"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">mutate</span>(<span class="at">RACE =</span> <span class="fu">droplevels</span>(RACE) <span class="sc">%&gt;%</span> formatters<span class="sc">::</span><span class="fu">with_label</span>(<span class="st">"Race"</span>))</span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="co"># Add variable for column split label</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">col_label =</span> <span class="st">"Treatment Effect Adjusted for Covariate"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The <code>summarize_coxreg</code> function fits, tidies and arranges a Cox regression model in a table layout using the <code>rtables</code> framework. For a Cox regression model, arguments <code>variables</code>, <code>control</code>, and <code>at</code> can be specified (see <code>?summarize_coxreg</code> for more details and customization options). All variables specified within <code>variables</code> must be present in the data used when building the table.</p>
+<p>To see the same model as a <code>data.frame</code> object, these three arguments (as well as the data) can be passed to the <code>fit_coxreg_univar</code> function, and the resulting list tidied using <code><a href="https://generics.r-lib.org/reference/tidy.html">broom::tidy()</a></code>.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="coxt01_cache/html/variant1_16c6e4d2f0d1ec72707a4c3aa0b768ba">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">summarize_coxreg</span>(<span class="at">variables =</span> variables) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb2-14"><a href="#cb2-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model       Treatment Effect Adjusted for Covariate     
+                                           n     Hazard Ratio       95% CI       p-value 
+—————————————————————————————————————————————————————————————————————————————————————————
+Treatment:                                                                               
+  A: Drug X vs control (B: Placebo)       247        0.97        (0.66, 1.43)     0.8934 
+Covariate:                                                                               
+  Age                                     247        0.95        (0.65, 1.40)     0.7948 
+  Sex                                     247        0.98        (0.67, 1.43)     0.8970 
+  Race                                    247        0.98        (0.67, 1.44)     0.9239 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The argument <code>control</code> can be used to modify standard outputs; <code>control_coxreg()</code> helps in adopting the right settings (see <code>?control_coxreg</code>). For instance, <code>control</code> is used to include the interaction terms.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="coxt01_cache/html/variant2_c67d3777e2c03e901bae8cb2e9ce08d9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">control =</span> <span class="fu">control_coxreg</span>(<span class="at">interaction =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb4-14"><a href="#cb4-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb4-16"><a href="#cb4-16"></a></span>
+<span id="cb4-17"><a href="#cb4-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb4-18"><a href="#cb4-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             
+                                          n    Hazard Ratio      95% CI      p-value   Interaction p-value
+——————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment:                                                                                                
+  A: Drug X vs control (B: Placebo)      247       0.97       (0.66, 1.43)   0.8934                       
+Covariate:                                                                                                
+  Age                                    247                                                 0.7878       
+    34                                             0.95       (0.65, 1.40)                                
+  Race                                   247                                                 0.6850       
+    ASIAN                                          1.05       (0.63, 1.75)                                
+    BLACK OR AFRICAN AMERICAN                      1.08       (0.51, 2.29)                                
+    WHITE                                          0.67       (0.27, 1.71)                                </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The optional argument <code>at</code> allows the user to provide the expected level of estimation for the interaction when the predictor is a quantitative variable. For instance, it might be relevant to choose the age at which the hazard ratio should be estimated. If no input is provided to <code>at</code>, the median value is used in the row name (as in the previous tab).</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="coxt01_cache/html/variant3_b1738b5cf98cbfc01b7a5486b826ad7a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a></span>
+<span id="cb6-8"><a href="#cb6-8"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">control =</span> <span class="fu">control_coxreg</span>(<span class="at">interaction =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">at =</span> <span class="fu">list</span>(<span class="at">AGE =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">40</span>, <span class="dv">50</span>)),</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb6-15"><a href="#cb6-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb6-17"><a href="#cb6-17"></a></span>
+<span id="cb6-18"><a href="#cb6-18"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb6-19"><a href="#cb6-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             
+                                          n    Hazard Ratio      95% CI      p-value   Interaction p-value
+——————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment:                                                                                                
+  A: Drug X vs control (B: Placebo)      247       0.97       (0.66, 1.43)   0.8934                       
+Covariate:                                                                                                
+  Age                                    247                                                 0.7878       
+    30                                             0.98       (0.63, 1.51)                                
+    40                                             0.91       (0.54, 1.51)                                
+    50                                             0.84       (0.32, 2.20)                                
+  Sex                                    247                                                 0.1455       
+    F                                              0.77       (0.47, 1.27)                                
+    M                                              1.38       (0.75, 2.52)                                </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Additional controls can be customized using <code>control_coxreg</code> (see <code>?control_coxreg</code>) such as the ties calculation method and the confidence level. Stratification variables can be added via the <code>strata</code> element of the <code>variables</code> list.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="coxt01_cache/html/variant4_2cd182dd42a3fc87f266296007337f9c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"RACE"</span>),</span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="at">strata =</span> <span class="st">"SEX"</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>)</span>
+<span id="cb8-8"><a href="#cb8-8"></a></span>
+<span id="cb8-9"><a href="#cb8-9"></a>control <span class="ot">&lt;-</span> <span class="fu">control_coxreg</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="at">ties =</span> <span class="st">"breslow"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>  <span class="at">interaction =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>  <span class="at">conf_level =</span> <span class="fl">0.90</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>)</span>
+<span id="cb8-14"><a href="#cb8-14"></a></span>
+<span id="cb8-15"><a href="#cb8-15"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">control =</span> control,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">at =</span> <span class="fu">list</span>(<span class="at">AGE =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">40</span>, <span class="dv">50</span>)),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb8-26"><a href="#cb8-26"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model                Treatment Effect Adjusted for Covariate             
+                                          n    Hazard Ratio      90% CI      p-value   Interaction p-value
+——————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment:                                                                                                
+  A: Drug X vs control (B: Placebo)      247       0.98       (0.71, 1.35)   0.9063                       
+Covariate:                                                                                                
+  Age                                    247                                                 0.7733       
+    30                                             0.98       (0.68, 1.42)                                
+    40                                             0.91       (0.59, 1.39)                                
+    50                                             0.84       (0.38, 1.87)                                
+  Race                                   247                                                 0.6501       
+    ASIAN                                          1.07       (0.64, 1.77)                                
+    BLACK OR AFRICAN AMERICAN                      1.08       (0.51, 2.29)                                
+    WHITE                                          0.66       (0.26, 1.67)                                </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="coxt01_cache/html/teal_383dfc5f4774e7cfe42136f85fbbdc29">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a></span>
+<span id="cb10-4"><a href="#cb10-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-5"><a href="#cb10-5"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a></span>
+<span id="cb10-7"><a href="#cb10-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-8"><a href="#cb10-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-9"><a href="#cb10-9"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb10-10"><a href="#cb10-10"></a></span>
+<span id="cb10-11"><a href="#cb10-11"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-12"><a href="#cb10-12"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-13"><a href="#cb10-13"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-14"><a href="#cb10-14"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-15"><a href="#cb10-15"></a>  ),</span>
+<span id="cb10-16"><a href="#cb10-16"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-19"><a href="#cb10-19"></a>  )</span>
+<span id="cb10-20"><a href="#cb10-20"></a>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a></span>
+<span id="cb10-22"><a href="#cb10-22"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-23"><a href="#cb10-23"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-24"><a href="#cb10-24"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'adtte &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adtte"))'</span>),</span>
+<span id="cb10-26"><a href="#cb10-26"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>  ),</span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    <span class="fu">tm_t_coxreg</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>      <span class="at">label =</span> <span class="st">"Cox Reg."</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-33"><a href="#cb10-33"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-35"><a href="#cb10-35"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>      ),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-38"><a href="#cb10-38"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="cn">NULL</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>      ),</span>
+<span id="cb10-40"><a href="#cb10-40"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>        <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>), <span class="st">"AGE"</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>      ),</span>
+<span id="cb10-43"><a href="#cb10-43"></a>      <span class="at">multivariate =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>    )</span>
+<span id="cb10-45"><a href="#cb10-45"></a>  )</span>
+<span id="cb10-46"><a href="#cb10-46"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:55:29.2419 pid:7012 token:[] teal.modules.clinical Initializing tm_t_coxreg</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="coxt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="coxt01_cache/html/sessioninfo_f1df2bc72f0fdff922a914866147a30d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          
+[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        
+[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    
+[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        
+[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          
+[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       
+[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         
+[43] stringr_1.5.0         splines_4.3.1         assertthat_0.2.1     
+[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[49] sandwich_3.0-2        jsonlite_1.8.7        carData_3.0-5        
+[52] callr_3.7.3           car_3.1-2             teal.widgets_0.4.0   
+[55] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      
+[58] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             
+[61] codetools_0.2-19      stringi_1.7.12        gtable_0.3.4         
+[64] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[67] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[70] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[73] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[76] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[79] broom_1.0.5           teal.reporter_0.2.1   bslib_0.5.1          
+[82] httpuv_1.6.11         Rcpp_1.0.11           coda_0.19-4          
+[85] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[88] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="coxt01_cache/html/snapshot_a902a6fbce0dfaf0d49ccc761a22ed25">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/coxt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/efficacy/cmht01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">CMHT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/coxt02.html" class="pagination-link">
+        <span class="nav-page-text">COXT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> COXT01</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Cox Regression</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>Cox models are the most commonly used methods to estimate the magnitude of the effect in survival analyses.</span>
+<span id="cb16-11"><a href="#cb16-11"></a>It assumes proportional hazards; that is, it assumes that the ratio of the hazards of the two groups (e.g. two arms) is constant over time.</span>
+<span id="cb16-12"><a href="#cb16-12"></a>This ratio is referred to as the "hazard ratio" and is one of the most commonly reported metrics to describe the effect size in survival analysis.</span>
+<span id="cb16-13"><a href="#cb16-13"></a></span>
+<span id="cb16-14"><a href="#cb16-14"></a>::: panel-tabset</span>
+<span id="cb16-15"><a href="#cb16-15"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-16"><a href="#cb16-16"></a></span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-21"><a href="#cb16-21"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-22"><a href="#cb16-22"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-23"><a href="#cb16-23"></a></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-25"><a href="#cb16-25"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb16-26"><a href="#cb16-26"></a></span>
+<span id="cb16-27"><a href="#cb16-27"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-29"><a href="#cb16-29"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb16-30"><a href="#cb16-30"></a></span>
+<span id="cb16-31"><a href="#cb16-31"></a>adsl_filtered <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb16-32"><a href="#cb16-32"></a>  RACE <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>, <span class="st">"WHITE"</span>)</span>
+<span id="cb16-33"><a href="#cb16-33"></a>)</span>
+<span id="cb16-34"><a href="#cb16-34"></a>adtte_filtered <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">inner_join</span>(</span>
+<span id="cb16-35"><a href="#cb16-35"></a>  <span class="at">x =</span> adsl_filtered[, <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)],</span>
+<span id="cb16-36"><a href="#cb16-36"></a>  <span class="at">y =</span> adtte,</span>
+<span id="cb16-37"><a href="#cb16-37"></a>  <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb16-38"><a href="#cb16-38"></a>)</span>
+<span id="cb16-39"><a href="#cb16-39"></a></span>
+<span id="cb16-40"><a href="#cb16-40"></a>anl <span class="ot">&lt;-</span> adtte_filtered <span class="sc">%&gt;%</span></span>
+<span id="cb16-41"><a href="#cb16-41"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-42"><a href="#cb16-42"></a>  <span class="fu">mutate</span>(<span class="at">EVENT =</span> <span class="dv">1</span> <span class="sc">-</span> CNSR) <span class="sc">%&gt;%</span></span>
+<span id="cb16-43"><a href="#cb16-43"></a>  <span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B: Placebo"</span>, <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-44"><a href="#cb16-44"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">droplevels</span>(<span class="fu">relevel</span>(ARM, <span class="st">"B: Placebo"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a>  <span class="fu">mutate</span>(<span class="at">RACE =</span> <span class="fu">droplevels</span>(RACE) <span class="sc">%&gt;%</span> formatters<span class="sc">::</span><span class="fu">with_label</span>(<span class="st">"Race"</span>))</span>
+<span id="cb16-46"><a href="#cb16-46"></a></span>
+<span id="cb16-47"><a href="#cb16-47"></a><span class="co"># Add variable for column split label</span></span>
+<span id="cb16-48"><a href="#cb16-48"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">col_label =</span> <span class="st">"Treatment Effect Adjusted for Covariate"</span>)</span>
+<span id="cb16-49"><a href="#cb16-49"></a><span class="in">```</span></span>
+<span id="cb16-50"><a href="#cb16-50"></a></span>
+<span id="cb16-51"><a href="#cb16-51"></a><span class="fu">## Cox Regression</span></span>
+<span id="cb16-52"><a href="#cb16-52"></a></span>
+<span id="cb16-53"><a href="#cb16-53"></a>The <span class="in">`summarize_coxreg`</span> function fits, tidies and arranges a Cox regression model in a table layout using the <span class="in">`rtables`</span> framework.</span>
+<span id="cb16-54"><a href="#cb16-54"></a>For a Cox regression model, arguments <span class="in">`variables`</span>, <span class="in">`control`</span>, and <span class="in">`at`</span> can be specified (see <span class="in">`?summarize_coxreg`</span> for more details and customization options).</span>
+<span id="cb16-55"><a href="#cb16-55"></a>All variables specified within <span class="in">`variables`</span> must be present in the data used when building the table.</span>
+<span id="cb16-56"><a href="#cb16-56"></a></span>
+<span id="cb16-57"><a href="#cb16-57"></a>To see the same model as a <span class="in">`data.frame`</span> object, these three arguments (as well as the data) can be passed to the <span class="in">`fit_coxreg_univar`</span> function, and the resulting list tidied using <span class="in">`broom::tidy()`</span>.</span>
+<span id="cb16-58"><a href="#cb16-58"></a></span>
+<span id="cb16-59"><a href="#cb16-59"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-60"><a href="#cb16-60"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-61"><a href="#cb16-61"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-62"><a href="#cb16-62"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb16-63"><a href="#cb16-63"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-64"><a href="#cb16-64"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb16-65"><a href="#cb16-65"></a>)</span>
+<span id="cb16-66"><a href="#cb16-66"></a></span>
+<span id="cb16-67"><a href="#cb16-67"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-68"><a href="#cb16-68"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-69"><a href="#cb16-69"></a>  <span class="fu">summarize_coxreg</span>(<span class="at">variables =</span> variables) <span class="sc">%&gt;%</span></span>
+<span id="cb16-70"><a href="#cb16-70"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb16-71"><a href="#cb16-71"></a></span>
+<span id="cb16-72"><a href="#cb16-72"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb16-73"><a href="#cb16-73"></a>result</span>
+<span id="cb16-74"><a href="#cb16-74"></a><span class="in">```</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a></span>
+<span id="cb16-76"><a href="#cb16-76"></a><span class="fu">## Cox Regression &lt;br/&gt; with Interaction Term</span></span>
+<span id="cb16-77"><a href="#cb16-77"></a></span>
+<span id="cb16-78"><a href="#cb16-78"></a>The argument <span class="in">`control`</span> can be used to modify standard outputs; <span class="in">`control_coxreg()`</span> helps in adopting the right settings (see <span class="in">`?control_coxreg`</span>).</span>
+<span id="cb16-79"><a href="#cb16-79"></a>For instance, <span class="in">`control`</span> is used to include the interaction terms.</span>
+<span id="cb16-80"><a href="#cb16-80"></a></span>
+<span id="cb16-81"><a href="#cb16-81"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-82"><a href="#cb16-82"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-83"><a href="#cb16-83"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-84"><a href="#cb16-84"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb16-85"><a href="#cb16-85"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-86"><a href="#cb16-86"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb16-87"><a href="#cb16-87"></a>)</span>
+<span id="cb16-88"><a href="#cb16-88"></a></span>
+<span id="cb16-89"><a href="#cb16-89"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-90"><a href="#cb16-90"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-91"><a href="#cb16-91"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb16-92"><a href="#cb16-92"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb16-93"><a href="#cb16-93"></a>    <span class="at">control =</span> <span class="fu">control_coxreg</span>(<span class="at">interaction =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb16-94"><a href="#cb16-94"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb16-95"><a href="#cb16-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-96"><a href="#cb16-96"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb16-97"><a href="#cb16-97"></a></span>
+<span id="cb16-98"><a href="#cb16-98"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb16-99"><a href="#cb16-99"></a>result</span>
+<span id="cb16-100"><a href="#cb16-100"></a><span class="in">```</span></span>
+<span id="cb16-101"><a href="#cb16-101"></a></span>
+<span id="cb16-102"><a href="#cb16-102"></a><span class="fu">## Cox Regression &lt;br/&gt; Specifying Covariates</span></span>
+<span id="cb16-103"><a href="#cb16-103"></a></span>
+<span id="cb16-104"><a href="#cb16-104"></a>The optional argument <span class="in">`at`</span> allows the user to provide the expected level of estimation for the interaction when the predictor is a quantitative variable.</span>
+<span id="cb16-105"><a href="#cb16-105"></a>For instance, it might be relevant to choose the age at which the hazard ratio should be estimated.</span>
+<span id="cb16-106"><a href="#cb16-106"></a>If no input is provided to <span class="in">`at`</span>, the median value is used in the row name (as in the previous tab).</span>
+<span id="cb16-107"><a href="#cb16-107"></a></span>
+<span id="cb16-108"><a href="#cb16-108"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-110"><a href="#cb16-110"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-111"><a href="#cb16-111"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb16-112"><a href="#cb16-112"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-113"><a href="#cb16-113"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb16-114"><a href="#cb16-114"></a>)</span>
+<span id="cb16-115"><a href="#cb16-115"></a></span>
+<span id="cb16-116"><a href="#cb16-116"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-117"><a href="#cb16-117"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-118"><a href="#cb16-118"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb16-119"><a href="#cb16-119"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb16-120"><a href="#cb16-120"></a>    <span class="at">control =</span> <span class="fu">control_coxreg</span>(<span class="at">interaction =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb16-121"><a href="#cb16-121"></a>    <span class="at">at =</span> <span class="fu">list</span>(<span class="at">AGE =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">40</span>, <span class="dv">50</span>)),</span>
+<span id="cb16-122"><a href="#cb16-122"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb16-123"><a href="#cb16-123"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-124"><a href="#cb16-124"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb16-125"><a href="#cb16-125"></a></span>
+<span id="cb16-126"><a href="#cb16-126"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb16-127"><a href="#cb16-127"></a>result</span>
+<span id="cb16-128"><a href="#cb16-128"></a><span class="in">```</span></span>
+<span id="cb16-129"><a href="#cb16-129"></a></span>
+<span id="cb16-130"><a href="#cb16-130"></a><span class="fu">## Cox Regression Setting &lt;br/&gt; Strata, Ties, Alpha Level</span></span>
+<span id="cb16-131"><a href="#cb16-131"></a></span>
+<span id="cb16-132"><a href="#cb16-132"></a>Additional controls can be customized using <span class="in">`control_coxreg`</span> (see <span class="in">`?control_coxreg`</span>) such as the ties calculation method and the confidence level.</span>
+<span id="cb16-133"><a href="#cb16-133"></a>Stratification variables can be added via the <span class="in">`strata`</span> element of the <span class="in">`variables`</span> list.</span>
+<span id="cb16-134"><a href="#cb16-134"></a></span>
+<span id="cb16-135"><a href="#cb16-135"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-136"><a href="#cb16-136"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-137"><a href="#cb16-137"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-138"><a href="#cb16-138"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb16-139"><a href="#cb16-139"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-140"><a href="#cb16-140"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"RACE"</span>),</span>
+<span id="cb16-141"><a href="#cb16-141"></a>  <span class="at">strata =</span> <span class="st">"SEX"</span></span>
+<span id="cb16-142"><a href="#cb16-142"></a>)</span>
+<span id="cb16-143"><a href="#cb16-143"></a></span>
+<span id="cb16-144"><a href="#cb16-144"></a>control <span class="ot">&lt;-</span> <span class="fu">control_coxreg</span>(</span>
+<span id="cb16-145"><a href="#cb16-145"></a>  <span class="at">ties =</span> <span class="st">"breslow"</span>,</span>
+<span id="cb16-146"><a href="#cb16-146"></a>  <span class="at">interaction =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-147"><a href="#cb16-147"></a>  <span class="at">conf_level =</span> <span class="fl">0.90</span></span>
+<span id="cb16-148"><a href="#cb16-148"></a>)</span>
+<span id="cb16-149"><a href="#cb16-149"></a></span>
+<span id="cb16-150"><a href="#cb16-150"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a>  <span class="fu">split_cols_by</span>(<span class="st">"col_label"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-152"><a href="#cb16-152"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb16-153"><a href="#cb16-153"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb16-154"><a href="#cb16-154"></a>    <span class="at">control =</span> control,</span>
+<span id="cb16-155"><a href="#cb16-155"></a>    <span class="at">at =</span> <span class="fu">list</span>(<span class="at">AGE =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">40</span>, <span class="dv">50</span>)),</span>
+<span id="cb16-156"><a href="#cb16-156"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"hr"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>, <span class="st">"pval_inter"</span>)</span>
+<span id="cb16-157"><a href="#cb16-157"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb16-159"><a href="#cb16-159"></a></span>
+<span id="cb16-160"><a href="#cb16-160"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb16-161"><a href="#cb16-161"></a>result</span>
+<span id="cb16-162"><a href="#cb16-162"></a><span class="in">```</span></span>
+<span id="cb16-163"><a href="#cb16-163"></a></span>
+<span id="cb16-164"><a href="#cb16-164"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-165"><a href="#cb16-165"></a></span>
+<span id="cb16-166"><a href="#cb16-166"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-167"><a href="#cb16-167"></a></span>
+<span id="cb16-168"><a href="#cb16-168"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-169"><a href="#cb16-169"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb16-170"><a href="#cb16-170"></a></span>
+<span id="cb16-171"><a href="#cb16-171"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-172"><a href="#cb16-172"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-173"><a href="#cb16-173"></a></span>
+<span id="cb16-174"><a href="#cb16-174"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-175"><a href="#cb16-175"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb16-176"><a href="#cb16-176"></a></span>
+<span id="cb16-177"><a href="#cb16-177"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-178"><a href="#cb16-178"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-179"><a href="#cb16-179"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb16-180"><a href="#cb16-180"></a></span>
+<span id="cb16-181"><a href="#cb16-181"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-182"><a href="#cb16-182"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb16-183"><a href="#cb16-183"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb16-184"><a href="#cb16-184"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb16-185"><a href="#cb16-185"></a>  ),</span>
+<span id="cb16-186"><a href="#cb16-186"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb16-187"><a href="#cb16-187"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb16-188"><a href="#cb16-188"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb16-189"><a href="#cb16-189"></a>  )</span>
+<span id="cb16-190"><a href="#cb16-190"></a>)</span>
+<span id="cb16-191"><a href="#cb16-191"></a></span>
+<span id="cb16-192"><a href="#cb16-192"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-193"><a href="#cb16-193"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-194"><a href="#cb16-194"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'adsl &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb16-195"><a href="#cb16-195"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'adtte &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adtte"))'</span>),</span>
+<span id="cb16-196"><a href="#cb16-196"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-197"><a href="#cb16-197"></a>  ),</span>
+<span id="cb16-198"><a href="#cb16-198"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-199"><a href="#cb16-199"></a>    <span class="fu">tm_t_coxreg</span>(</span>
+<span id="cb16-200"><a href="#cb16-200"></a>      <span class="at">label =</span> <span class="st">"Cox Reg."</span>,</span>
+<span id="cb16-201"><a href="#cb16-201"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb16-202"><a href="#cb16-202"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb16-203"><a href="#cb16-203"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb16-204"><a href="#cb16-204"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-205"><a href="#cb16-205"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span></span>
+<span id="cb16-206"><a href="#cb16-206"></a>      ),</span>
+<span id="cb16-207"><a href="#cb16-207"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-208"><a href="#cb16-208"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="cn">NULL</span></span>
+<span id="cb16-209"><a href="#cb16-209"></a>      ),</span>
+<span id="cb16-210"><a href="#cb16-210"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-211"><a href="#cb16-211"></a>        <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>), <span class="st">"AGE"</span></span>
+<span id="cb16-212"><a href="#cb16-212"></a>      ),</span>
+<span id="cb16-213"><a href="#cb16-213"></a>      <span class="at">multivariate =</span> <span class="cn">FALSE</span></span>
+<span id="cb16-214"><a href="#cb16-214"></a>    )</span>
+<span id="cb16-215"><a href="#cb16-215"></a>  )</span>
+<span id="cb16-216"><a href="#cb16-216"></a>)</span>
+<span id="cb16-217"><a href="#cb16-217"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-218"><a href="#cb16-218"></a><span class="in">```</span></span>
+<span id="cb16-219"><a href="#cb16-219"></a></span>
+<span id="cb16-220"><a href="#cb16-220"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-221"><a href="#cb16-221"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - COXT02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
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+div.sourceCode { margin: 1em 0; }
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+@media screen {
+div.sourceCode { overflow: auto; }
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+div.sourceCode
+  {   }
+@media screen {
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+</style>
+
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+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
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+<meta name="quarto:offset" content="../../">
+<link href="../../tables/efficacy/dort01.html" rel="next">
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+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">COXT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Multivariable Cox Regression</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>Analysis based on multivariable Cox models is usually not performed for the Clinical Study Report (CSR) or regulatory documents, serving exploratory purposes only (e.g.&nbsp;for publication). In practice, the model usually includes only the main effects (without interaction terms). It produces the estimates for each of the covariates included in the model. The analysis follows the same principles (i.e.&nbsp;stratified vs.&nbsp;unstratified analysis and tie handling) as the general Cox model analysis also used in <code>COXT01</code>. Since there is usually no pre-specified hypothesis testing for such analysis, the p-values must be interpreted with caution.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Multivariable Cox Regression</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Multivariable Cox Regression <br> with Interaction Term</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Multivariable Cox Regression <br> Specifying Covariates</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Multivariable Cox Regression <br> Specifying Covariates from ADSUB</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Multivariable Cox Regression <br> Setting Strata, Ties, Alpha Level, Statistics</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Multivariable Cox Regression <br> with Selection Process for Covariates</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="coxt02_cache/html/setup_f07f7a6853227054dfdd23e89ed49fe3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(broom)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>anl <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"F"</span>, <span class="st">"M"</span>),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    RACE <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>, <span class="st">"WHITE"</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">ARM =</span> <span class="fu">droplevels</span>(<span class="fu">relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">RACE =</span> <span class="fu">droplevels</span>(RACE)</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  <span class="fu">mutate</span>(<span class="at">EVENT =</span> <span class="dv">1</span> <span class="sc">-</span> CNSR) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">ARM =</span> <span class="st">"Planned Arm"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">SEX =</span> <span class="st">"Sex"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">RACE =</span> <span class="st">"Race"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">AGE =</span> <span class="st">"Age"</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The <code>summarize_coxreg</code> function fits, tidies and arranges a Cox regression model in a table layout using the <code>rtables</code> framework. For a multivariable Cox regression model, argument <code>multivar</code> must be set to <code>TRUE</code>. Arguments <code>variables</code> and <code>control</code> can be specified to set up the model (see <code>?summarize_coxreg</code> for more details and customization options). All variables specified within <code>variables</code> must be present in the data used when building the table.</p>
+<p>To see the same model as a <code>data.frame</code> object, these two arguments (as well as the data) can be passed to the <code>fit_coxreg_multivar</code> function, and the resulting list tidied using <code><a href="https://generics.r-lib.org/reference/tidy.html">broom::tidy()</a></code>.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="coxt02_cache/html/variant1_f088fe3ead72d42b4beb518a23db6400">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">summarize_coxreg</span>(<span class="at">variables =</span> variables, <span class="at">multivar =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb2-11"><a href="#cb2-11"></a></span>
+<span id="cb2-12"><a href="#cb2-12"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model   Hazard Ratio      95% CI      p-value
+——————————————————————————————————————————————————————————————————————————————
+Treatment:                                                                    
+  Planned Arm (reference = B: Placebo)                                 0.2643 
+    A: Drug X                                0.96       (0.66, 1.42)   0.8536 
+    C: Combination                           1.27       (0.88, 1.83)   0.2010 
+Covariate:                                                                    
+  Sex (reference = F)                                                         
+    M                                        1.09       (0.80, 1.48)   0.5987 
+  Age                                                                         
+    All                                      0.99       (0.97, 1.01)   0.5104 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The estimation of interaction terms is not supported.</p>
+<p>Interaction terms are not included in the GDSR. For this reason and because we must take precautions when fitting such models, this functionality has not been translated in <code>fit_coxreg_multivar</code>. Please remove interaction terms or, if required by the study, refer to the <code><a href="https://rdrr.io/pkg/survival/man/coxph.html">survival::coxph</a></code> function. Aside from this, using <code>tern</code> the developer must add the necessary variables to the analysis dataset during pre-processing based on ADVS or ADSUB. An example can be found in <code>DMT01</code>.</p>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>This option is not supported.</p>
+<p>See the <em>Multivariable Cox Regression with Interaction Term</em> tab for more details.</p>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>This option is not supported.</p>
+<p>See the <em>Multivariable Cox Regression with Interaction Term</em> tab for more details.</p>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Additional controls can be customized using <code>control_coxreg</code> (see <code>?control_coxreg</code>) such as the ties calculation method and the confidence level. Stratification variables can be added via the <code>strata</code> element of the <code>variables</code> list.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="coxt02_cache/html/variant2_cb5aabc35e2d90ea05ad3ba9de47cbb2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="at">strata =</span> <span class="st">"RACE"</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>control <span class="ot">&lt;-</span> <span class="fu">control_coxreg</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="at">conf_level =</span> <span class="fl">0.9</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="at">ties =</span> <span class="st">"efron"</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">control =</span> control,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">multivar =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"hr"</span>, <span class="st">"ci"</span>)</span>
+<span id="cb4-20"><a href="#cb4-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb4-22"><a href="#cb4-22"></a></span>
+<span id="cb4-23"><a href="#cb4-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb4-24"><a href="#cb4-24"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Effect/Covariate Included in the Model   Hazard Ratio      90% CI   
+————————————————————————————————————————————————————————————————————
+Treatment:                                                          
+  Planned Arm Code (reference = ARM A)                              
+    ARM B                                    1.03       (0.74, 1.42)
+    ARM C                                    1.30       (0.96, 1.77)
+Covariate:                                                          
+  Sex (reference = F)                                               
+    M                                        1.08       (0.83, 1.40)
+  Age                                                               
+    All                                      0.99       (0.98, 1.01)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<p>See the <em>Multivariable Cox Regression with Interaction Term</em> tab.</p>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:30}" data-hash="coxt02_cache/html/teal_b489e07e6ea4cb04b5fe63b552ac51c9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a></span>
+<span id="cb6-4"><a href="#cb6-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-5"><a href="#cb6-5"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ),</span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb6-14"><a href="#cb6-14"></a>  )</span>
+<span id="cb6-15"><a href="#cb6-15"></a>)</span>
+<span id="cb6-16"><a href="#cb6-16"></a></span>
+<span id="cb6-17"><a href="#cb6-17"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'adsl &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'adtte &lt;- synthetic_cdisc_dataset("latest", "adtte")'</span>),</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  ),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="fu">tm_t_coxreg</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>      <span class="at">label =</span> <span class="st">"Cox Reg."</span>,</span>
+<span id="cb6-26"><a href="#cb6-26"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb6-28"><a href="#cb6-28"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb6-29"><a href="#cb6-29"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-30"><a href="#cb6-30"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>      ),</span>
+<span id="cb6-32"><a href="#cb6-32"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-33"><a href="#cb6-33"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="cn">NULL</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>      ),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>        <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>), <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb6-37"><a href="#cb6-37"></a>      ),</span>
+<span id="cb6-38"><a href="#cb6-38"></a>      <span class="at">multivariate =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>    )</span>
+<span id="cb6-40"><a href="#cb6-40"></a>  )</span>
+<span id="cb6-41"><a href="#cb6-41"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:01:35.4413 pid:7853 token:[] teal.modules.clinical Initializing tm_t_coxreg</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="coxt02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="coxt02_cache/html/sessioninfo_db7e3bd359da9bc1dabf59089edbfc94">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] broom_1.0.5                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+[13] scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          
+[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        
+[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    
+[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        
+[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          
+[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       
+[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         
+[43] stringr_1.5.0         splines_4.3.1         assertthat_0.2.1     
+[46] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[49] sandwich_3.0-2        jsonlite_1.8.7        carData_3.0-5        
+[52] callr_3.7.3           car_3.1-2             teal.widgets_0.4.0   
+[55] testthat_3.1.10       fontawesome_0.5.2     jquerylib_0.1.4      
+[58] tidyr_1.3.0           glue_1.6.2            ps_1.7.5             
+[61] codetools_0.2-19      stringi_1.7.12        gtable_0.3.4         
+[64] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[67] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[70] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[73] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[76] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[79] teal.reporter_0.2.1   bslib_0.5.1           httpuv_1.6.11        
+[82] Rcpp_1.0.11           coda_0.19-4           nlme_3.1-163         
+[85] checkmate_2.2.0       xfun_0.40             zoo_1.8-12           
+[88] forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="coxt02_cache/html/snapshot_cf4f798ce41a20bbd3097ad18a7c8b94">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/coxt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> COXT02</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Multivariable Cox Regression</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>Analysis based on multivariable Cox models is usually not performed for the Clinical Study Report (CSR) or regulatory documents, serving exploratory purposes only (e.g. for publication).</span>
+<span id="cb12-11"><a href="#cb12-11"></a>In practice, the model usually includes only the main effects (without interaction terms).</span>
+<span id="cb12-12"><a href="#cb12-12"></a>It produces the estimates for each of the covariates included in the model.</span>
+<span id="cb12-13"><a href="#cb12-13"></a>The analysis follows the same principles (i.e. stratified vs. unstratified analysis and tie handling) as the general Cox model analysis also used in <span class="in">`COXT01`</span>.</span>
+<span id="cb12-14"><a href="#cb12-14"></a>Since there is usually no pre-specified hypothesis testing for such analysis, the p-values must be interpreted with caution.</span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a>::: panel-tabset</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-18"><a href="#cb12-18"></a></span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-20"><a href="#cb12-20"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-21"><a href="#cb12-21"></a></span>
+<span id="cb12-22"><a href="#cb12-22"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-24"><a href="#cb12-24"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-25"><a href="#cb12-25"></a><span class="fu">library</span>(broom)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb12-28"><a href="#cb12-28"></a></span>
+<span id="cb12-29"><a href="#cb12-29"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb12-31"><a href="#cb12-31"></a></span>
+<span id="cb12-32"><a href="#cb12-32"></a>anl <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb12-33"><a href="#cb12-33"></a>  <span class="fu">filter</span>(</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>,</span>
+<span id="cb12-35"><a href="#cb12-35"></a>    SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"F"</span>, <span class="st">"M"</span>),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>    RACE <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>, <span class="st">"WHITE"</span>)</span>
+<span id="cb12-37"><a href="#cb12-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">ARM =</span> <span class="fu">droplevels</span>(<span class="fu">relevel</span>(ARM, <span class="st">"B: Placebo"</span>)),</span>
+<span id="cb12-40"><a href="#cb12-40"></a>    <span class="at">SEX =</span> <span class="fu">droplevels</span>(SEX),</span>
+<span id="cb12-41"><a href="#cb12-41"></a>    <span class="at">RACE =</span> <span class="fu">droplevels</span>(RACE)</span>
+<span id="cb12-42"><a href="#cb12-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-43"><a href="#cb12-43"></a>  <span class="fu">mutate</span>(<span class="at">EVENT =</span> <span class="dv">1</span> <span class="sc">-</span> CNSR) <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb12-45"><a href="#cb12-45"></a>    <span class="at">ARM =</span> <span class="st">"Planned Arm"</span>,</span>
+<span id="cb12-46"><a href="#cb12-46"></a>    <span class="at">SEX =</span> <span class="st">"Sex"</span>,</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">RACE =</span> <span class="st">"Race"</span>,</span>
+<span id="cb12-48"><a href="#cb12-48"></a>    <span class="at">AGE =</span> <span class="st">"Age"</span></span>
+<span id="cb12-49"><a href="#cb12-49"></a>  )</span>
+<span id="cb12-50"><a href="#cb12-50"></a><span class="in">```</span></span>
+<span id="cb12-51"><a href="#cb12-51"></a></span>
+<span id="cb12-52"><a href="#cb12-52"></a><span class="fu">## Multivariable Cox Regression</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a></span>
+<span id="cb12-54"><a href="#cb12-54"></a>The <span class="in">`summarize_coxreg`</span> function fits, tidies and arranges a Cox regression model in a table layout using the <span class="in">`rtables`</span> framework.</span>
+<span id="cb12-55"><a href="#cb12-55"></a>For a multivariable Cox regression model, argument <span class="in">`multivar`</span> must be set to <span class="in">`TRUE`</span>.</span>
+<span id="cb12-56"><a href="#cb12-56"></a>Arguments <span class="in">`variables`</span> and <span class="in">`control`</span> can be specified to set up the model (see <span class="in">`?summarize_coxreg`</span> for more details and customization options).</span>
+<span id="cb12-57"><a href="#cb12-57"></a>All variables specified within <span class="in">`variables`</span> must be present in the data used when building the table.</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a>To see the same model as a <span class="in">`data.frame`</span> object, these two arguments (as well as the data) can be passed to the <span class="in">`fit_coxreg_multivar`</span> function, and the resulting list tidied using <span class="in">`broom::tidy()`</span>.</span>
+<span id="cb12-60"><a href="#cb12-60"></a></span>
+<span id="cb12-61"><a href="#cb12-61"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb12-63"><a href="#cb12-63"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-64"><a href="#cb12-64"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb12-66"><a href="#cb12-66"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>)</span>
+<span id="cb12-67"><a href="#cb12-67"></a>)</span>
+<span id="cb12-68"><a href="#cb12-68"></a></span>
+<span id="cb12-69"><a href="#cb12-69"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a>  <span class="fu">summarize_coxreg</span>(<span class="at">variables =</span> variables, <span class="at">multivar =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-71"><a href="#cb12-71"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb12-72"><a href="#cb12-72"></a></span>
+<span id="cb12-73"><a href="#cb12-73"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb12-74"><a href="#cb12-74"></a>result</span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="in">```</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a></span>
+<span id="cb12-77"><a href="#cb12-77"></a><span class="fu">## Multivariable Cox Regression &lt;br/&gt; with Interaction Term</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a></span>
+<span id="cb12-79"><a href="#cb12-79"></a>The estimation of interaction terms is not supported.</span>
+<span id="cb12-80"><a href="#cb12-80"></a></span>
+<span id="cb12-81"><a href="#cb12-81"></a>Interaction terms are not included in the GDSR.</span>
+<span id="cb12-82"><a href="#cb12-82"></a>For this reason and because we must take precautions when fitting such models, this functionality has not been translated in <span class="in">`fit_coxreg_multivar`</span>.</span>
+<span id="cb12-83"><a href="#cb12-83"></a>Please remove interaction terms or, if required by the study, refer to the <span class="in">`survival::coxph`</span> function.</span>
+<span id="cb12-84"><a href="#cb12-84"></a>Aside from this, using <span class="in">`tern`</span> the developer must add the necessary variables to the analysis dataset during pre-processing based on ADVS or ADSUB.</span>
+<span id="cb12-85"><a href="#cb12-85"></a>An example can be found in <span class="in">`DMT01`</span>.</span>
+<span id="cb12-86"><a href="#cb12-86"></a></span>
+<span id="cb12-87"><a href="#cb12-87"></a><span class="fu">## Multivariable Cox Regression &lt;br/&gt; Specifying Covariates</span></span>
+<span id="cb12-88"><a href="#cb12-88"></a></span>
+<span id="cb12-89"><a href="#cb12-89"></a>This option is not supported.</span>
+<span id="cb12-90"><a href="#cb12-90"></a></span>
+<span id="cb12-91"><a href="#cb12-91"></a>See the *Multivariable Cox Regression with Interaction Term* tab for more details.</span>
+<span id="cb12-92"><a href="#cb12-92"></a></span>
+<span id="cb12-93"><a href="#cb12-93"></a><span class="fu">## Multivariable Cox Regression &lt;br/&gt; Specifying Covariates from ADSUB</span></span>
+<span id="cb12-94"><a href="#cb12-94"></a></span>
+<span id="cb12-95"><a href="#cb12-95"></a>This option is not supported.</span>
+<span id="cb12-96"><a href="#cb12-96"></a></span>
+<span id="cb12-97"><a href="#cb12-97"></a>See the *Multivariable Cox Regression with Interaction Term* tab for more details.</span>
+<span id="cb12-98"><a href="#cb12-98"></a></span>
+<span id="cb12-99"><a href="#cb12-99"></a><span class="fu">## Multivariable Cox Regression &lt;br/&gt; Setting Strata, Ties, Alpha Level, Statistics</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a></span>
+<span id="cb12-101"><a href="#cb12-101"></a>Additional controls can be customized using <span class="in">`control_coxreg`</span> (see <span class="in">`?control_coxreg`</span>) such as the ties calculation method and the confidence level.</span>
+<span id="cb12-102"><a href="#cb12-102"></a>Stratification variables can be added via the <span class="in">`strata`</span> element of the <span class="in">`variables`</span> list.</span>
+<span id="cb12-103"><a href="#cb12-103"></a></span>
+<span id="cb12-104"><a href="#cb12-104"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-105"><a href="#cb12-105"></a>variables <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb12-106"><a href="#cb12-106"></a>  <span class="at">time =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-107"><a href="#cb12-107"></a>  <span class="at">event =</span> <span class="st">"EVENT"</span>,</span>
+<span id="cb12-108"><a href="#cb12-108"></a>  <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb12-109"><a href="#cb12-109"></a>  <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb12-110"><a href="#cb12-110"></a>  <span class="at">strata =</span> <span class="st">"RACE"</span></span>
+<span id="cb12-111"><a href="#cb12-111"></a>)</span>
+<span id="cb12-112"><a href="#cb12-112"></a></span>
+<span id="cb12-113"><a href="#cb12-113"></a>control <span class="ot">&lt;-</span> <span class="fu">control_coxreg</span>(</span>
+<span id="cb12-114"><a href="#cb12-114"></a>  <span class="at">conf_level =</span> <span class="fl">0.9</span>,</span>
+<span id="cb12-115"><a href="#cb12-115"></a>  <span class="at">ties =</span> <span class="st">"efron"</span></span>
+<span id="cb12-116"><a href="#cb12-116"></a>)</span>
+<span id="cb12-117"><a href="#cb12-117"></a></span>
+<span id="cb12-118"><a href="#cb12-118"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-119"><a href="#cb12-119"></a>  <span class="fu">summarize_coxreg</span>(</span>
+<span id="cb12-120"><a href="#cb12-120"></a>    <span class="at">variables =</span> variables,</span>
+<span id="cb12-121"><a href="#cb12-121"></a>    <span class="at">control =</span> control,</span>
+<span id="cb12-122"><a href="#cb12-122"></a>    <span class="at">multivar =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-123"><a href="#cb12-123"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"hr"</span>, <span class="st">"ci"</span>)</span>
+<span id="cb12-124"><a href="#cb12-124"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-125"><a href="#cb12-125"></a>  <span class="fu">append_topleft</span>(<span class="st">"Effect/Covariate Included in the Model"</span>)</span>
+<span id="cb12-126"><a href="#cb12-126"></a></span>
+<span id="cb12-127"><a href="#cb12-127"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl)</span>
+<span id="cb12-128"><a href="#cb12-128"></a>result</span>
+<span id="cb12-129"><a href="#cb12-129"></a><span class="in">```</span></span>
+<span id="cb12-130"><a href="#cb12-130"></a></span>
+<span id="cb12-131"><a href="#cb12-131"></a><span class="fu">## Multivariable Cox Regression &lt;br/&gt; with Selection Process for Covariates</span></span>
+<span id="cb12-132"><a href="#cb12-132"></a></span>
+<span id="cb12-133"><a href="#cb12-133"></a>See the *Multivariable Cox Regression with Interaction Term* tab.</span>
+<span id="cb12-134"><a href="#cb12-134"></a></span>
+<span id="cb12-135"><a href="#cb12-135"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-136"><a href="#cb12-136"></a></span>
+<span id="cb12-137"><a href="#cb12-137"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-138"><a href="#cb12-138"></a></span>
+<span id="cb12-139"><a href="#cb12-139"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-140"><a href="#cb12-140"></a><span class="co">#| screenshot.opts = list(delay = 30)</span></span>
+<span id="cb12-141"><a href="#cb12-141"></a></span>
+<span id="cb12-142"><a href="#cb12-142"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-143"><a href="#cb12-143"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-144"><a href="#cb12-144"></a></span>
+<span id="cb12-145"><a href="#cb12-145"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-146"><a href="#cb12-146"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb12-147"><a href="#cb12-147"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb12-148"><a href="#cb12-148"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb12-149"><a href="#cb12-149"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb12-150"><a href="#cb12-150"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb12-151"><a href="#cb12-151"></a>  ),</span>
+<span id="cb12-152"><a href="#cb12-152"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb12-153"><a href="#cb12-153"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb12-154"><a href="#cb12-154"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb12-155"><a href="#cb12-155"></a>  )</span>
+<span id="cb12-156"><a href="#cb12-156"></a>)</span>
+<span id="cb12-157"><a href="#cb12-157"></a></span>
+<span id="cb12-158"><a href="#cb12-158"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-159"><a href="#cb12-159"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-160"><a href="#cb12-160"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'adsl &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-161"><a href="#cb12-161"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'adtte &lt;- synthetic_cdisc_dataset("latest", "adtte")'</span>),</span>
+<span id="cb12-162"><a href="#cb12-162"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-163"><a href="#cb12-163"></a>  ),</span>
+<span id="cb12-164"><a href="#cb12-164"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-165"><a href="#cb12-165"></a>    <span class="fu">tm_t_coxreg</span>(</span>
+<span id="cb12-166"><a href="#cb12-166"></a>      <span class="at">label =</span> <span class="st">"Cox Reg."</span>,</span>
+<span id="cb12-167"><a href="#cb12-167"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb12-168"><a href="#cb12-168"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb12-169"><a href="#cb12-169"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb12-170"><a href="#cb12-170"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-171"><a href="#cb12-171"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>), <span class="st">"OS"</span></span>
+<span id="cb12-172"><a href="#cb12-172"></a>      ),</span>
+<span id="cb12-173"><a href="#cb12-173"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-174"><a href="#cb12-174"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>), <span class="cn">NULL</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a>      ),</span>
+<span id="cb12-176"><a href="#cb12-176"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-177"><a href="#cb12-177"></a>        <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"RACE"</span>), <span class="fu">c</span>(<span class="st">"AGE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb12-178"><a href="#cb12-178"></a>      ),</span>
+<span id="cb12-179"><a href="#cb12-179"></a>      <span class="at">multivariate =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-180"><a href="#cb12-180"></a>    )</span>
+<span id="cb12-181"><a href="#cb12-181"></a>  )</span>
+<span id="cb12-182"><a href="#cb12-182"></a>)</span>
+<span id="cb12-183"><a href="#cb12-183"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-184"><a href="#cb12-184"></a><span class="in">```</span></span>
+<span id="cb12-185"><a href="#cb12-185"></a></span>
+<span id="cb12-186"><a href="#cb12-186"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-187"><a href="#cb12-187"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">DORT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Duration of Response</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Modifying Analysis Details <br> like Conf. Type and Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table Modifying Time Point for <br> the “XX Months duration” Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="dort01_cache/html/setup_3142897591eeb3f8b76665a9073bdd08">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adtte_f <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRSD"</span> <span class="sc">&amp;</span> BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">is_not_event =</span> CNSR <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">EVNT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>        is_event <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Responders with subsequent event (%)"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>        is_event <span class="sc">==</span> <span class="cn">FALSE</span> <span class="sc">~</span> <span class="st">"Responders without subsequent event (%)"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>      ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Responders with subsequent event (%)"</span>, <span class="st">"Responders without subsequent event (%)"</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    ),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">EVNTDESC =</span> <span class="fu">factor</span>(EVNTDESC)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="dort01_cache/html/variant1_655c79fe62ad4e0b268a1edcd7ba3fc5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">time_point =</span> <span class="dv">12</span></span>
+<span id="cb2-43"><a href="#cb2-43"></a>  )</span>
+<span id="cb2-44"><a href="#cb2-44"></a></span>
+<span id="cb2-45"><a href="#cb2-45"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb2-47"><a href="#cb2-47"></a></span>
+<span id="cb2-48"><a href="#cb2-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                            A: Drug X    B: Placebo   C: Combination
+                                             (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————
+Responders                                      68           73             62      
+  Responders with subsequent event (%)      46 (67.6%)   39 (53.4%)     32 (51.6%)  
+    Earliest contributing event                                                     
+      Death                                     26           24             16      
+      Disease Progression                       20           15             16      
+  Responders without subsequent event (%)   22 (32.4%)   34 (46.6%)     30 (48.4%)  
+Duration of response (Months)                                                       
+  Median                                       5.3          6.2            5.3      
+    95% CI                                  (4.6, 5.8)   (5.4, 6.3)     (4.6, 5.8)  
+  25% and 75%-ile                            3.8, 6.3     4.6, 6.4       4.0, 6.1   
+  Range (censored)                          3.6 to 6.3   3.3 to 6.5     3.3 to 6.4  
+  Range (event)                             0.5 to 6.4   0.9 to 6.5     0.6 to 6.6  
+12 Months duration                                                                  
+  Patients remaining at risk                    NA           NA             NA      
+  Event Free Rate (%)                           NA           NA             NA      
+  95% CI                                        NA           NA             NA      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="dort01_cache/html/variant2_e55fb502b5b510fbf80e81fe827d2e2a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb4-30"><a href="#cb4-30"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="at">table_names =</span> <span class="st">"surv_time"</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-42"><a href="#cb4-42"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb4-44"><a href="#cb4-44"></a>    <span class="at">table_names =</span> <span class="st">"cox_pair"</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>  )</span>
+<span id="cb4-46"><a href="#cb4-46"></a></span>
+<span id="cb4-47"><a href="#cb4-47"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb4-49"><a href="#cb4-49"></a></span>
+<span id="cb4-50"><a href="#cb4-50"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                            A: Drug X     B: Placebo    C: Combination
+                                             (N=134)       (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Responders                                      68            73              62      
+  Responders with subsequent event (%)      46 (67.6%)    39 (53.4%)      32 (51.6%)  
+    Earliest contributing event                                                       
+      Death                                     26            24              16      
+      Disease Progression                       20            15              16      
+  Responders without subsequent event (%)   22 (32.4%)    34 (46.6%)      30 (48.4%)  
+Duration of response (Months)                                                         
+  Median                                       5.3           6.2             5.3      
+    95% CI                                  (4.6, 5.8)    (5.4, 6.3)      (4.6, 5.8)  
+  25% and 75%-ile                            3.8, 6.3      4.6, 6.4        4.0, 6.1   
+  Range (censored)                          3.6 to 6.3    3.3 to 6.5      3.3 to 6.4  
+  Range (event)                             0.5 to 6.4    0.9 to 6.5      0.6 to 6.6  
+Unstratified Analysis                                                                 
+  p-value (log-rank)                                        0.0223          0.6659    
+  Hazard Ratio                                               0.60            0.90     
+  95% CI                                                 (0.39, 0.93)    (0.57, 1.44) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="dort01_cache/html/variant3_4e6bdf93d2822977f8e9699ef1285de0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-33"><a href="#cb6-33"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    <span class="at">control =</span> <span class="fu">control_surv_time</span>(<span class="at">conf_level =</span> <span class="fl">0.90</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>)</span>
+<span id="cb6-38"><a href="#cb6-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.975</span>)</span>
+<span id="cb6-45"><a href="#cb6-45"></a>  )</span>
+<span id="cb6-46"><a href="#cb6-46"></a></span>
+<span id="cb6-47"><a href="#cb6-47"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-48"><a href="#cb6-48"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb6-49"><a href="#cb6-49"></a></span>
+<span id="cb6-50"><a href="#cb6-50"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                            A: Drug X    B: Placebo   C: Combination
+                                             (N=134)      (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————
+Responders                                      68           73             62      
+  Responders with subsequent event (%)      46 (67.6%)   39 (53.4%)     32 (51.6%)  
+    Earliest contributing event                                                     
+      Death                                     26           24             16      
+      Disease Progression                       20           15             16      
+  Responders without subsequent event (%)   22 (32.4%)   34 (46.6%)     30 (48.4%)  
+Duration of response (Months)                                                       
+  Median                                       5.3          6.2            5.3      
+    90% CI                                  (4.6, 5.8)   (5.5, 6.3)     (4.6, 5.7)  
+  25% and 75%-ile                            3.8, 6.3     4.6, 6.4       4.0, 6.1   
+  Range (censored)                          3.6 to 6.3   3.3 to 6.5     3.3 to 6.4  
+  Range (event)                             0.5 to 6.4   0.9 to 6.5     0.6 to 6.6  
+12 Months duration                                                                  
+  Patients remaining at risk                    NA           NA             NA      
+  Event Free Rate (%)                           NA           NA             NA      
+  97.5% CI                                      NA           NA             NA      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="dort01_cache/html/variant4_6bc9fbb07e4a39c5f606d923e3e838c9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb8-13"><a href="#cb8-13"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb8-23"><a href="#cb8-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">time_point =</span> <span class="dv">6</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  )</span>
+<span id="cb8-44"><a href="#cb8-44"></a></span>
+<span id="cb8-45"><a href="#cb8-45"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                              A: Drug X        B: Placebo     C: Combination
+                                               (N=134)          (N=134)          (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————————
+Responders                                        68               73               62      
+  Responders with subsequent event (%)        46 (67.6%)       39 (53.4%)       32 (51.6%)  
+    Earliest contributing event                                                             
+      Death                                       26               24               16      
+      Disease Progression                         20               15               16      
+  Responders without subsequent event (%)     22 (32.4%)       34 (46.6%)       30 (48.4%)  
+Duration of response (Months)                                                               
+  Median                                         5.3              6.2              5.3      
+    95% CI                                    (4.6, 5.8)       (5.4, 6.3)       (4.6, 5.8)  
+  25% and 75%-ile                              3.8, 6.3         4.6, 6.4         4.0, 6.1   
+  Range (censored)                            3.6 to 6.3       3.3 to 6.5       3.3 to 6.4  
+  Range (event)                               0.5 to 6.4       0.9 to 6.5       0.6 to 6.6  
+6 Months duration                                                                           
+  Patients remaining at risk                      10               18               7       
+  Event Free Rate (%)                           33.46            50.23            30.56     
+  95% CI                                    (20.88, 46.05)   (36.54, 63.92)   (13.56, 47.57)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:36}" data-hash="dort01_cache/html/teal_a7f80d87dd565d72d20a14690a938e83">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-9"><a href="#cb10-9"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADSL)</span>
+<span id="cb10-10"><a href="#cb10-10"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADTTE)</span>
+<span id="cb10-11"><a href="#cb10-11"></a></span>
+<span id="cb10-12"><a href="#cb10-12"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-13"><a href="#cb10-13"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-14"><a href="#cb10-14"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-16"><a href="#cb10-16"></a>  ),</span>
+<span id="cb10-17"><a href="#cb10-17"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-19"><a href="#cb10-19"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-20"><a href="#cb10-20"></a>  )</span>
+<span id="cb10-21"><a href="#cb10-21"></a>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb10-26"><a href="#cb10-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  ),</span>
+<span id="cb10-29"><a href="#cb10-29"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      <span class="at">label =</span> <span class="st">"Time To Event Table"</span>,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb10-35"><a href="#cb10-35"></a>        <span class="st">"ARM"</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>      ),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-39"><a href="#cb10-39"></a>        <span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-40"><a href="#cb10-40"></a>        <span class="st">"CRSD"</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>      ),</span>
+<span id="cb10-42"><a href="#cb10-42"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-43"><a href="#cb10-43"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb10-44"><a href="#cb10-44"></a>        <span class="st">"SEX"</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>      ),</span>
+<span id="cb10-46"><a href="#cb10-46"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">8</span>), <span class="dv">6</span>),</span>
+<span id="cb10-47"><a href="#cb10-47"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-48"><a href="#cb10-48"></a>        <span class="fu">variable_choices</span>(ADTTE, <span class="st">"EVNTDESC"</span>),</span>
+<span id="cb10-49"><a href="#cb10-49"></a>        <span class="st">"EVNTDESC"</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>      )</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    )</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  )</span>
+<span id="cb10-54"><a href="#cb10-54"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:04:38.6385 pid:8221 token:[] teal.modules.clinical Initializing tm_t_tte</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="dort01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="dort01_cache/html/sessioninfo_a9588793547039f1c407696071b4adcc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="dort01_cache/html/snapshot_82eb2a5c9e916a2c57167d164322d408">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/dort01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/efficacy/coxt02.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">COXT02</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/efficacy/lgrt02.html" class="pagination-link">
+        <span class="nav-page-text">LGRT02</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> DORT01</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Duration of Response</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-21"><a href="#cb16-21"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-25"><a href="#cb16-25"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb16-26"><a href="#cb16-26"></a></span>
+<span id="cb16-27"><a href="#cb16-27"></a>adtte_f <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRSD"</span> <span class="sc">&amp;</span> BMEASIFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-29"><a href="#cb16-29"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb16-30"><a href="#cb16-30"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb16-31"><a href="#cb16-31"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb16-32"><a href="#cb16-32"></a>    <span class="at">is_not_event =</span> CNSR <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb16-33"><a href="#cb16-33"></a>    <span class="at">EVNT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb16-34"><a href="#cb16-34"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb16-35"><a href="#cb16-35"></a>        is_event <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Responders with subsequent event (%)"</span>,</span>
+<span id="cb16-36"><a href="#cb16-36"></a>        is_event <span class="sc">==</span> <span class="cn">FALSE</span> <span class="sc">~</span> <span class="st">"Responders without subsequent event (%)"</span></span>
+<span id="cb16-37"><a href="#cb16-37"></a>      ),</span>
+<span id="cb16-38"><a href="#cb16-38"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Responders with subsequent event (%)"</span>, <span class="st">"Responders without subsequent event (%)"</span>)</span>
+<span id="cb16-39"><a href="#cb16-39"></a>    ),</span>
+<span id="cb16-40"><a href="#cb16-40"></a>    <span class="at">EVNTDESC =</span> <span class="fu">factor</span>(EVNTDESC)</span>
+<span id="cb16-41"><a href="#cb16-41"></a>  )</span>
+<span id="cb16-42"><a href="#cb16-42"></a><span class="in">```</span></span>
+<span id="cb16-43"><a href="#cb16-43"></a></span>
+<span id="cb16-44"><a href="#cb16-44"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a></span>
+<span id="cb16-46"><a href="#cb16-46"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-47"><a href="#cb16-47"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-48"><a href="#cb16-48"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-49"><a href="#cb16-49"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-50"><a href="#cb16-50"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-51"><a href="#cb16-51"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb16-52"><a href="#cb16-52"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb16-53"><a href="#cb16-53"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb16-54"><a href="#cb16-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-55"><a href="#cb16-55"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-56"><a href="#cb16-56"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-57"><a href="#cb16-57"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-59"><a href="#cb16-59"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-60"><a href="#cb16-60"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-61"><a href="#cb16-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-62"><a href="#cb16-62"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-63"><a href="#cb16-63"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb16-64"><a href="#cb16-64"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb16-65"><a href="#cb16-65"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-66"><a href="#cb16-66"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-67"><a href="#cb16-67"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-68"><a href="#cb16-68"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb16-69"><a href="#cb16-69"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-70"><a href="#cb16-70"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-71"><a href="#cb16-71"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-72"><a href="#cb16-72"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb16-73"><a href="#cb16-73"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-74"><a href="#cb16-74"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb16-75"><a href="#cb16-75"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-76"><a href="#cb16-76"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-77"><a href="#cb16-77"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-78"><a href="#cb16-78"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-79"><a href="#cb16-79"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb16-80"><a href="#cb16-80"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-81"><a href="#cb16-81"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb16-82"><a href="#cb16-82"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span></span>
+<span id="cb16-83"><a href="#cb16-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-84"><a href="#cb16-84"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb16-85"><a href="#cb16-85"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-86"><a href="#cb16-86"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb16-87"><a href="#cb16-87"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-88"><a href="#cb16-88"></a>    <span class="at">time_point =</span> <span class="dv">12</span></span>
+<span id="cb16-89"><a href="#cb16-89"></a>  )</span>
+<span id="cb16-90"><a href="#cb16-90"></a></span>
+<span id="cb16-91"><a href="#cb16-91"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb16-93"><a href="#cb16-93"></a></span>
+<span id="cb16-94"><a href="#cb16-94"></a>result</span>
+<span id="cb16-95"><a href="#cb16-95"></a><span class="in">```</span></span>
+<span id="cb16-96"><a href="#cb16-96"></a></span>
+<span id="cb16-97"><a href="#cb16-97"></a><span class="fu">## Table Selecting &lt;br/&gt; Sections to Display</span></span>
+<span id="cb16-98"><a href="#cb16-98"></a></span>
+<span id="cb16-99"><a href="#cb16-99"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-100"><a href="#cb16-100"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-101"><a href="#cb16-101"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-102"><a href="#cb16-102"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-103"><a href="#cb16-103"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-104"><a href="#cb16-104"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb16-105"><a href="#cb16-105"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb16-106"><a href="#cb16-106"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb16-107"><a href="#cb16-107"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-108"><a href="#cb16-108"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-109"><a href="#cb16-109"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-110"><a href="#cb16-110"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-111"><a href="#cb16-111"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-112"><a href="#cb16-112"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-113"><a href="#cb16-113"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-114"><a href="#cb16-114"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-115"><a href="#cb16-115"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-116"><a href="#cb16-116"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb16-117"><a href="#cb16-117"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb16-118"><a href="#cb16-118"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-119"><a href="#cb16-119"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-120"><a href="#cb16-120"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-121"><a href="#cb16-121"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb16-122"><a href="#cb16-122"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-123"><a href="#cb16-123"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-124"><a href="#cb16-124"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-125"><a href="#cb16-125"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb16-126"><a href="#cb16-126"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-127"><a href="#cb16-127"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb16-128"><a href="#cb16-128"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-129"><a href="#cb16-129"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-130"><a href="#cb16-130"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-131"><a href="#cb16-131"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-132"><a href="#cb16-132"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb16-133"><a href="#cb16-133"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-134"><a href="#cb16-134"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb16-135"><a href="#cb16-135"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-136"><a href="#cb16-136"></a>    <span class="at">table_names =</span> <span class="st">"surv_time"</span></span>
+<span id="cb16-137"><a href="#cb16-137"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-138"><a href="#cb16-138"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb16-139"><a href="#cb16-139"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-140"><a href="#cb16-140"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-141"><a href="#cb16-141"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb16-142"><a href="#cb16-142"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb16-143"><a href="#cb16-143"></a>    <span class="at">table_names =</span> <span class="st">"cox_pair"</span></span>
+<span id="cb16-144"><a href="#cb16-144"></a>  )</span>
+<span id="cb16-145"><a href="#cb16-145"></a></span>
+<span id="cb16-146"><a href="#cb16-146"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-147"><a href="#cb16-147"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb16-148"><a href="#cb16-148"></a></span>
+<span id="cb16-149"><a href="#cb16-149"></a>result</span>
+<span id="cb16-150"><a href="#cb16-150"></a><span class="in">```</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a></span>
+<span id="cb16-152"><a href="#cb16-152"></a><span class="fu">## Table Modifying Analysis Details &lt;br/&gt; like Conf. Type and Alpha Level</span></span>
+<span id="cb16-153"><a href="#cb16-153"></a></span>
+<span id="cb16-154"><a href="#cb16-154"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-155"><a href="#cb16-155"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-156"><a href="#cb16-156"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-157"><a href="#cb16-157"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-158"><a href="#cb16-158"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-159"><a href="#cb16-159"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb16-160"><a href="#cb16-160"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb16-161"><a href="#cb16-161"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb16-162"><a href="#cb16-162"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-163"><a href="#cb16-163"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-164"><a href="#cb16-164"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-165"><a href="#cb16-165"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-166"><a href="#cb16-166"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-167"><a href="#cb16-167"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-168"><a href="#cb16-168"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-169"><a href="#cb16-169"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-170"><a href="#cb16-170"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-171"><a href="#cb16-171"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb16-172"><a href="#cb16-172"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb16-173"><a href="#cb16-173"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-174"><a href="#cb16-174"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-175"><a href="#cb16-175"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-176"><a href="#cb16-176"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb16-177"><a href="#cb16-177"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-178"><a href="#cb16-178"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-179"><a href="#cb16-179"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-180"><a href="#cb16-180"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb16-181"><a href="#cb16-181"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-182"><a href="#cb16-182"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb16-183"><a href="#cb16-183"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-184"><a href="#cb16-184"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-185"><a href="#cb16-185"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-186"><a href="#cb16-186"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-187"><a href="#cb16-187"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb16-188"><a href="#cb16-188"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-189"><a href="#cb16-189"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb16-190"><a href="#cb16-190"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-191"><a href="#cb16-191"></a>    <span class="at">control =</span> <span class="fu">control_surv_time</span>(<span class="at">conf_level =</span> <span class="fl">0.90</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>)</span>
+<span id="cb16-192"><a href="#cb16-192"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-193"><a href="#cb16-193"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb16-194"><a href="#cb16-194"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-195"><a href="#cb16-195"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb16-196"><a href="#cb16-196"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-197"><a href="#cb16-197"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb16-198"><a href="#cb16-198"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.975</span>)</span>
+<span id="cb16-199"><a href="#cb16-199"></a>  )</span>
+<span id="cb16-200"><a href="#cb16-200"></a></span>
+<span id="cb16-201"><a href="#cb16-201"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-202"><a href="#cb16-202"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb16-203"><a href="#cb16-203"></a></span>
+<span id="cb16-204"><a href="#cb16-204"></a>result</span>
+<span id="cb16-205"><a href="#cb16-205"></a><span class="in">```</span></span>
+<span id="cb16-206"><a href="#cb16-206"></a></span>
+<span id="cb16-207"><a href="#cb16-207"></a><span class="fu">## Table Modifying Time Point for &lt;br/&gt; the "XX Months duration" Analysis</span></span>
+<span id="cb16-208"><a href="#cb16-208"></a></span>
+<span id="cb16-209"><a href="#cb16-209"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-210"><a href="#cb16-210"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-211"><a href="#cb16-211"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-212"><a href="#cb16-212"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb16-213"><a href="#cb16-213"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-214"><a href="#cb16-214"></a>    <span class="at">values =</span> <span class="fu">unique</span>(adtte<span class="sc">$</span>USUBJID),</span>
+<span id="cb16-215"><a href="#cb16-215"></a>    <span class="at">.labels =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb16-216"><a href="#cb16-216"></a>    <span class="at">.stats =</span> <span class="st">"count"</span></span>
+<span id="cb16-217"><a href="#cb16-217"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-218"><a href="#cb16-218"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-219"><a href="#cb16-219"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-220"><a href="#cb16-220"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-221"><a href="#cb16-221"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-222"><a href="#cb16-222"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-223"><a href="#cb16-223"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-224"><a href="#cb16-224"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-225"><a href="#cb16-225"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-226"><a href="#cb16-226"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb16-227"><a href="#cb16-227"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb16-228"><a href="#cb16-228"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Responders with subsequent event (%)"</span>),</span>
+<span id="cb16-229"><a href="#cb16-229"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-230"><a href="#cb16-230"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb16-231"><a href="#cb16-231"></a>    <span class="at">indent_mod =</span> 2L,</span>
+<span id="cb16-232"><a href="#cb16-232"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-233"><a href="#cb16-233"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-234"><a href="#cb16-234"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb16-235"><a href="#cb16-235"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb16-236"><a href="#cb16-236"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb16-237"><a href="#cb16-237"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Responders without subsequent event (%)"</span>),</span>
+<span id="cb16-238"><a href="#cb16-238"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> 1L),</span>
+<span id="cb16-239"><a href="#cb16-239"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb16-240"><a href="#cb16-240"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-241"><a href="#cb16-241"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-242"><a href="#cb16-242"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb16-243"><a href="#cb16-243"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-244"><a href="#cb16-244"></a>    <span class="at">var_labels =</span> <span class="st">"Duration of response (Months)"</span>,</span>
+<span id="cb16-245"><a href="#cb16-245"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span></span>
+<span id="cb16-246"><a href="#cb16-246"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-247"><a href="#cb16-247"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb16-248"><a href="#cb16-248"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb16-249"><a href="#cb16-249"></a>    <span class="at">var_labels =</span> <span class="st">"Months duration"</span>,</span>
+<span id="cb16-250"><a href="#cb16-250"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb16-251"><a href="#cb16-251"></a>    <span class="at">time_point =</span> <span class="dv">6</span></span>
+<span id="cb16-252"><a href="#cb16-252"></a>  )</span>
+<span id="cb16-253"><a href="#cb16-253"></a></span>
+<span id="cb16-254"><a href="#cb16-254"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-255"><a href="#cb16-255"></a>  <span class="fu">prune_table</span>(<span class="at">prune_func =</span> prune_zeros_only)</span>
+<span id="cb16-256"><a href="#cb16-256"></a></span>
+<span id="cb16-257"><a href="#cb16-257"></a>result</span>
+<span id="cb16-258"><a href="#cb16-258"></a><span class="in">```</span></span>
+<span id="cb16-259"><a href="#cb16-259"></a></span>
+<span id="cb16-260"><a href="#cb16-260"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-261"><a href="#cb16-261"></a></span>
+<span id="cb16-262"><a href="#cb16-262"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-263"><a href="#cb16-263"></a></span>
+<span id="cb16-264"><a href="#cb16-264"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-265"><a href="#cb16-265"></a><span class="co">#| screenshot.opts = list(delay = 36)</span></span>
+<span id="cb16-266"><a href="#cb16-266"></a></span>
+<span id="cb16-267"><a href="#cb16-267"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-268"><a href="#cb16-268"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-269"><a href="#cb16-269"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-270"><a href="#cb16-270"></a></span>
+<span id="cb16-271"><a href="#cb16-271"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-272"><a href="#cb16-272"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb16-273"><a href="#cb16-273"></a></span>
+<span id="cb16-274"><a href="#cb16-274"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-275"><a href="#cb16-275"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADSL)</span>
+<span id="cb16-276"><a href="#cb16-276"></a>ADTTE <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADTTE)</span>
+<span id="cb16-277"><a href="#cb16-277"></a></span>
+<span id="cb16-278"><a href="#cb16-278"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-279"><a href="#cb16-279"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb16-280"><a href="#cb16-280"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb16-281"><a href="#cb16-281"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb16-282"><a href="#cb16-282"></a>  ),</span>
+<span id="cb16-283"><a href="#cb16-283"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb16-284"><a href="#cb16-284"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb16-285"><a href="#cb16-285"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb16-286"><a href="#cb16-286"></a>  )</span>
+<span id="cb16-287"><a href="#cb16-287"></a>)</span>
+<span id="cb16-288"><a href="#cb16-288"></a></span>
+<span id="cb16-289"><a href="#cb16-289"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-290"><a href="#cb16-290"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-291"><a href="#cb16-291"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb16-292"><a href="#cb16-292"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, ADTTE, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb16-293"><a href="#cb16-293"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-294"><a href="#cb16-294"></a>  ),</span>
+<span id="cb16-295"><a href="#cb16-295"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-296"><a href="#cb16-296"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb16-297"><a href="#cb16-297"></a>      <span class="at">label =</span> <span class="st">"Time To Event Table"</span>,</span>
+<span id="cb16-298"><a href="#cb16-298"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb16-299"><a href="#cb16-299"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-300"><a href="#cb16-300"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb16-301"><a href="#cb16-301"></a>        <span class="st">"ARM"</span></span>
+<span id="cb16-302"><a href="#cb16-302"></a>      ),</span>
+<span id="cb16-303"><a href="#cb16-303"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb16-304"><a href="#cb16-304"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-305"><a href="#cb16-305"></a>        <span class="fu">value_choices</span>(ADTTE, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb16-306"><a href="#cb16-306"></a>        <span class="st">"CRSD"</span></span>
+<span id="cb16-307"><a href="#cb16-307"></a>      ),</span>
+<span id="cb16-308"><a href="#cb16-308"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-309"><a href="#cb16-309"></a>        <span class="fu">variable_choices</span>(ADSL, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb16-310"><a href="#cb16-310"></a>        <span class="st">"SEX"</span></span>
+<span id="cb16-311"><a href="#cb16-311"></a>      ),</span>
+<span id="cb16-312"><a href="#cb16-312"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">8</span>), <span class="dv">6</span>),</span>
+<span id="cb16-313"><a href="#cb16-313"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-314"><a href="#cb16-314"></a>        <span class="fu">variable_choices</span>(ADTTE, <span class="st">"EVNTDESC"</span>),</span>
+<span id="cb16-315"><a href="#cb16-315"></a>        <span class="st">"EVNTDESC"</span>,</span>
+<span id="cb16-316"><a href="#cb16-316"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-317"><a href="#cb16-317"></a>      )</span>
+<span id="cb16-318"><a href="#cb16-318"></a>    )</span>
+<span id="cb16-319"><a href="#cb16-319"></a>  )</span>
+<span id="cb16-320"><a href="#cb16-320"></a>)</span>
+<span id="cb16-321"><a href="#cb16-321"></a></span>
+<span id="cb16-322"><a href="#cb16-322"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-323"><a href="#cb16-323"></a><span class="in">```</span></span>
+<span id="cb16-324"><a href="#cb16-324"></a></span>
+<span id="cb16-325"><a href="#cb16-325"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-326"><a href="#cb16-326"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LGRT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Multi-Variable Logistic Regression</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Multi-Variable Logistic Regression</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Multi-Variable Logistic Regression <br> with Interaction Term</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Multi-Variable Logistic Regression <br> Specifying Covariates</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Multi-Variable Logistic Regression Setting <br> an Event, Alpha Level, and Level for Interaction</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lgrt02_cache/html/setup_dc24e6fd457e4605d28c111ad771b9d1">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"F"</span>, <span class="st">"M"</span>))</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"BESRSPI"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">Response =</span> <span class="fu">case_when</span>(AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"PR"</span>, <span class="st">"CR"</span>) <span class="sc">~</span> <span class="dv">1</span>, <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">0</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(SEX, <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">RACE =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      RACE,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-23"><a href="#cb1-23"></a>        <span class="st">"AMERICAN INDIAN OR ALASKA NATIVE"</span>, <span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>        <span class="st">"WHITE"</span>, <span class="st">"MULTIPLE"</span>, <span class="st">"NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER"</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>      )</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    )</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">var_relabel</span>(<span class="at">Response =</span> <span class="st">"Response"</span>, <span class="at">SEX =</span> <span class="st">"Sex"</span>, <span class="at">RACE =</span> <span class="st">"Race"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lgrt02_cache/html/variant1_028dc9645d297acad9b723a0996c7a75">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  adrs,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">response =</span> <span class="st">"Response"</span>, <span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>))</span>
+<span id="cb2-4"><a href="#cb2-4"></a>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb2-7"><a href="#cb2-7"></a></span>
+<span id="cb2-8"><a href="#cb2-8"></a><span class="co"># empty string flag</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">append_topleft</span>(<span class="st">"Logistic regression"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Logistic regression          Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio    Wald 95% CI    p-value
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Planned Arm Code                     2                                                                               0.0408 
+  Reference ARM A, n = 134                                                                                                  
+  ARM B, n = 134                     1                  -2.094             1.080           0.12      (0.01, 1.02)    0.0524 
+  ARM C, n = 132                     1                  -0.074             1.423           0.93      (0.06, 15.09)   0.9584 
+Sex                                                                                                                         
+  Reference M, n = 169                                                                                                      
+  F, n = 231                         1                  0.331              0.695           1.39      (0.36, 5.44)    0.6339 
+Age                                                                                                                         
+  Age                                1                  0.070              0.054           1.07      (0.97, 1.19)    0.1945 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lgrt02_cache/html/variant2_671300b6b77ca099fc7f97d084788e82">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  adrs,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">interaction =</span> <span class="st">"SEX"</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  )</span>
+<span id="cb4-9"><a href="#cb4-9"></a>)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a><span class="co"># empty string flag</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">append_topleft</span>(<span class="st">"Logistic regression with interaction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb4-23"><a href="#cb4-23"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Logistic regression with interaction    Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 95% CI     p-value
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Age                                                                                                                                      
+  Age                                           1                  0.067              0.054           1.07       (0.96, 1.19)     0.2084 
+Planned Arm Code                                2                                                                                 0.4882 
+  Reference ARM A, n = 134                                                                                                               
+  ARM B, n = 134                                1                 -17.850            2362.767                                     0.9940 
+    Sex                                                                                                                                  
+      F                                                                                               0.23       (0.02, 2.11)            
+      M                                                                                               0.00      (0.00, &gt;999.99)          
+  ARM C, n = 132                                1                 -16.442            2362.767                                     0.9944 
+    Sex                                                                                                                                  
+      F                                                                                             &gt;999.99     (0.00, &gt;999.99)          
+      M                                                                                               0.00      (0.00, &gt;999.99)          
+Sex                                                                                                                                      
+  Reference M, n = 169                                                                                                                   
+  F, n = 231                                    1                 -16.044            2362.767                                     0.9946 
+    Planned Arm Code                                                                                                                     
+      ARM A                                                                                           0.00      (0.00, &gt;999.99)          
+      ARM B                                                                                           1.39       (0.29, 6.59)            
+      ARM C                                                                                         &gt;999.99     (0.00, &gt;999.99)          
+Interaction of Planned Arm Code * Sex           2                                                                                 0.9999 
+  Reference ARM A or M, n = 248                                                                                                          
+  ARM B * F, n = 82                             1                  16.373            2362.767                                     0.9945 
+  ARM C * F, n = 70                             1                  32.492            3156.732                                     0.9918 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="lgrt02_cache/html/variant3_f33442eff1c05bf27374ae5de96c4e42">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  adrs,</span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>  )</span>
+<span id="cb6-8"><a href="#cb6-8"></a>)</span>
+<span id="cb6-9"><a href="#cb6-9"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a><span class="co"># empty string flag</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb6-14"><a href="#cb6-14"></a></span>
+<span id="cb6-15"><a href="#cb6-15"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">append_topleft</span>(<span class="st">"y ~ ARM + SEX + AGE + RACE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb6-22"><a href="#cb6-22"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>y ~ ARM + SEX + AGE + RACE                             Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 95% CI     p-value
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Planned Arm Code                                               2                                                                                 0.0346 
+  Reference ARM A, n = 134                                                                                                                              
+  ARM B, n = 134                                               1                  -2.162             1.084           0.12       (0.01, 0.96)     0.0461 
+  ARM C, n = 132                                               1                  -0.090             1.426           0.91       (0.06, 14.97)    0.9499 
+Sex                                                                                                                                                     
+  Reference M, n = 169                                                                                                                                  
+  F, n = 231                                                   1                  0.364              0.701           1.44       (0.36, 5.69)     0.6032 
+Age                                                                                                                                                     
+  Age                                                          1                  0.071              0.053           1.07       (0.97, 1.19)     0.1866 
+Race                                                           5                                                                                 0.9685 
+  Reference AMERICAN INDIAN OR ALASKA NATIVE, n = 25                                                                                                    
+  ASIAN, n = 208                                               1                 -16.246            2017.122         0.00      (0.00, &gt;999.99)   0.9936 
+  BLACK OR AFRICAN AMERICAN, n = 91                            1                 -15.205            2017.122         0.00      (0.00, &gt;999.99)   0.9940 
+  WHITE, n = 74                                                1                 -15.955            2017.122         0.00      (0.00, &gt;999.99)   0.9937 
+  MULTIPLE, n = 1                                              1                  -0.363           10941.553         0.70      (0.00, &gt;999.99)   1.0000 
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER, n = 1             1                  1.036            10941.553         2.82      (0.00, &gt;999.99)   0.9999 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="lgrt02_cache/html/variant4_4492988a584e7ad1e8f3c465dc85ea59">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb8-2"><a href="#cb8-2"></a>  adrs,</span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">interaction =</span> <span class="st">"AGE"</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  ),</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="at">response_definition =</span> <span class="st">"1 - response"</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.9</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level, <span class="at">at =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">50</span>))</span>
+<span id="cb8-13"><a href="#cb8-13"></a></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co"># empty string flag</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb8-16"><a href="#cb8-16"></a></span>
+<span id="cb8-17"><a href="#cb8-17"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb8-21"><a href="#cb8-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>  <span class="fu">append_topleft</span>(<span class="st">"Estimations at age 30 and 50"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb8-24"><a href="#cb8-24"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Estimations at age 30 and 50            Degrees of Freedom   Parameter Estimate   Standard Error   Odds Ratio     Wald 90% CI      p-value
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Sex                                                                                                                                       
+  Reference M, n = 169                                                                                                                    
+  F, n = 231                                    1                  -0.381             0.710           0.68        (0.21, 2.20)     0.5915 
+Planned Arm Code                                2                                                                                  0.2768 
+  Reference ARM A, n = 134                                                                                                                
+  ARM B, n = 134                                1                 -20.020             13.714                                       0.1443 
+    Age                                                                                                                                   
+      30                                                                                             234.91     (0.30, &gt;999.99)           
+      50                                                                                            &gt;999.99     (0.04, &gt;999.99)           
+  ARM C, n = 132                                1                 -15.622             14.810                                       0.2915 
+    Age                                                                                                                                   
+      30                                                                                             31.95      (0.03, &gt;999.99)           
+      50                                                                                            &gt;999.99     (&lt;0.01, &gt;999.99)          
+Age                                                                                                                                       
+  Age                                           1                  -0.877             0.581                                        0.1309 
+    Planned Arm Code                                                                                                                      
+      ARM A                                                                                           0.42        (0.16, 1.08)            
+      ARM B                                                                                           0.97        (0.89, 1.06)            
+      ARM C                                                                                           0.79        (0.55, 1.11)            
+Interaction of Planned Arm Code * Age           2                                                                                  0.2213 
+  Reference ARM A, n = 134                                                                                                                
+  ARM B, n = 134                                1                  0.849              0.583                                        0.1449 
+  ARM C, n = 132                                1                  0.636              0.618                                        0.3034 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="lgrt02_cache/html/teal_b4d89adfd5e4425e76073bb18ddeef95">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a></span>
+<span id="cb10-5"><a href="#cb10-5"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BESRSPI"</span>, <span class="st">"INVET"</span>))</span>
+<span id="cb10-8"><a href="#cb10-8"></a></span>
+<span id="cb10-9"><a href="#cb10-9"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-11"><a href="#cb10-11"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-12"><a href="#cb10-12"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-13"><a href="#cb10-13"></a>  ),</span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-16"><a href="#cb10-16"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-17"><a href="#cb10-17"></a>  )</span>
+<span id="cb10-18"><a href="#cb10-18"></a>)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-21"><a href="#cb10-21"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-22"><a href="#cb10-22"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-23"><a href="#cb10-23"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb10-24"><a href="#cb10-24"></a>      <span class="st">"ADRS"</span>, ADRS,</span>
+<span id="cb10-25"><a href="#cb10-25"></a>      <span class="at">code =</span> <span class="st">'ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs") %&gt;% filter(PARAMCD %in% c("BESRSPI", "INVET"))'</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>    ),</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  ),</span>
+<span id="cb10-29"><a href="#cb10-29"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    <span class="fu">tm_t_logistic</span>(</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      <span class="at">label =</span> <span class="st">"Logistic Regression"</span>,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-35"><a href="#cb10-35"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>      ),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-38"><a href="#cb10-38"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-39"><a href="#cb10-39"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-40"><a href="#cb10-40"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>      ),</span>
+<span id="cb10-42"><a href="#cb10-42"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-43"><a href="#cb10-43"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>, <span class="st">"BMRKR1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb10-44"><a href="#cb10-44"></a>        <span class="at">selected =</span> <span class="st">"SEX"</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>      )</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    )</span>
+<span id="cb10-47"><a href="#cb10-47"></a>  )</span>
+<span id="cb10-48"><a href="#cb10-48"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:59:41.2210 pid:7559 token:[] teal.modules.clinical Initializing tm_t_logistic</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lgrt02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lgrt02_cache/html/sessioninfo_eafb39526d9c7631dc2022427838f9a3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] abind_1.4-5           multcomp_1.4-25       withr_2.5.0          
+[25] purrr_1.0.2           shinyWidgets_0.8.0    geepack_1.3.9        
+[28] grid_4.3.1            fansi_1.0.4           teal.logger_0.1.3    
+[31] xtable_1.8-4          colorspace_2.1-0      ggplot2_3.4.3        
+[34] emmeans_1.8.8         scales_1.2.1          MASS_7.3-60          
+[37] cli_3.6.1             mvtnorm_1.2-3         rmarkdown_2.25       
+[40] generics_0.1.3        rstudioapi_0.15.0     cachem_1.0.8         
+[43] splines_4.3.1         assertthat_0.2.1      vctrs_0.6.3          
+[46] webshot_0.5.5         Matrix_1.6-1.1        sandwich_3.0-2       
+[49] jsonlite_1.8.7        carData_3.0-5         callr_3.7.3          
+[52] car_3.1-2             teal.widgets_0.4.0    testthat_3.1.10      
+[55] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[58] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[61] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[64] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[67] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[70] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[73] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[76] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[79] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          
+[82] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[85] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[88] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lgrt02_cache/html/snapshot_73554cea160a8eb5997fe9c5c0ec3504">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/lgrt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> LGRT02</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Multi-Variable Logistic Regression</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-21"><a href="#cb16-21"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-25"><a href="#cb16-25"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb16-26"><a href="#cb16-26"></a></span>
+<span id="cb16-27"><a href="#cb16-27"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(SEX <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"F"</span>, <span class="st">"M"</span>))</span>
+<span id="cb16-29"><a href="#cb16-29"></a></span>
+<span id="cb16-30"><a href="#cb16-30"></a>adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb16-31"><a href="#cb16-31"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"BESRSPI"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-32"><a href="#cb16-32"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb16-33"><a href="#cb16-33"></a>    <span class="at">Response =</span> <span class="fu">case_when</span>(AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"PR"</span>, <span class="st">"CR"</span>) <span class="sc">~</span> <span class="dv">1</span>, <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">0</span>),</span>
+<span id="cb16-34"><a href="#cb16-34"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(SEX, <span class="fu">c</span>(<span class="st">"M"</span>, <span class="st">"F"</span>)),</span>
+<span id="cb16-35"><a href="#cb16-35"></a>    <span class="at">RACE =</span> <span class="fu">factor</span>(</span>
+<span id="cb16-36"><a href="#cb16-36"></a>      RACE,</span>
+<span id="cb16-37"><a href="#cb16-37"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb16-38"><a href="#cb16-38"></a>        <span class="st">"AMERICAN INDIAN OR ALASKA NATIVE"</span>, <span class="st">"ASIAN"</span>, <span class="st">"BLACK OR AFRICAN AMERICAN"</span>,</span>
+<span id="cb16-39"><a href="#cb16-39"></a>        <span class="st">"WHITE"</span>, <span class="st">"MULTIPLE"</span>, <span class="st">"NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER"</span></span>
+<span id="cb16-40"><a href="#cb16-40"></a>      )</span>
+<span id="cb16-41"><a href="#cb16-41"></a>    )</span>
+<span id="cb16-42"><a href="#cb16-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-43"><a href="#cb16-43"></a>  <span class="fu">var_relabel</span>(<span class="at">Response =</span> <span class="st">"Response"</span>, <span class="at">SEX =</span> <span class="st">"Sex"</span>, <span class="at">RACE =</span> <span class="st">"Race"</span>)</span>
+<span id="cb16-44"><a href="#cb16-44"></a><span class="in">```</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a></span>
+<span id="cb16-46"><a href="#cb16-46"></a><span class="fu">## Multi-Variable Logistic Regression</span></span>
+<span id="cb16-47"><a href="#cb16-47"></a></span>
+<span id="cb16-48"><a href="#cb16-48"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-49"><a href="#cb16-49"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb16-50"><a href="#cb16-50"></a>  adrs,</span>
+<span id="cb16-51"><a href="#cb16-51"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">response =</span> <span class="st">"Response"</span>, <span class="at">arm =</span> <span class="st">"ARMCD"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>))</span>
+<span id="cb16-52"><a href="#cb16-52"></a>)</span>
+<span id="cb16-53"><a href="#cb16-53"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb16-54"><a href="#cb16-54"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb16-55"><a href="#cb16-55"></a></span>
+<span id="cb16-56"><a href="#cb16-56"></a><span class="co"># empty string flag</span></span>
+<span id="cb16-57"><a href="#cb16-57"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb16-58"><a href="#cb16-58"></a></span>
+<span id="cb16-59"><a href="#cb16-59"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-60"><a href="#cb16-60"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb16-61"><a href="#cb16-61"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb16-62"><a href="#cb16-62"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb16-63"><a href="#cb16-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-64"><a href="#cb16-64"></a>  <span class="fu">append_topleft</span>(<span class="st">"Logistic regression"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-65"><a href="#cb16-65"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb16-66"><a href="#cb16-66"></a>result</span>
+<span id="cb16-67"><a href="#cb16-67"></a><span class="in">```</span></span>
+<span id="cb16-68"><a href="#cb16-68"></a></span>
+<span id="cb16-69"><a href="#cb16-69"></a><span class="fu">## Multi-Variable Logistic Regression &lt;br/&gt; with Interaction Term</span></span>
+<span id="cb16-70"><a href="#cb16-70"></a></span>
+<span id="cb16-71"><a href="#cb16-71"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-72"><a href="#cb16-72"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb16-73"><a href="#cb16-73"></a>  adrs,</span>
+<span id="cb16-74"><a href="#cb16-74"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-75"><a href="#cb16-75"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb16-76"><a href="#cb16-76"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb16-77"><a href="#cb16-77"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb16-78"><a href="#cb16-78"></a>    <span class="at">interaction =</span> <span class="st">"SEX"</span></span>
+<span id="cb16-79"><a href="#cb16-79"></a>  )</span>
+<span id="cb16-80"><a href="#cb16-80"></a>)</span>
+<span id="cb16-81"><a href="#cb16-81"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb16-82"><a href="#cb16-82"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb16-83"><a href="#cb16-83"></a></span>
+<span id="cb16-84"><a href="#cb16-84"></a><span class="co"># empty string flag</span></span>
+<span id="cb16-85"><a href="#cb16-85"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb16-86"><a href="#cb16-86"></a></span>
+<span id="cb16-87"><a href="#cb16-87"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-88"><a href="#cb16-88"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb16-89"><a href="#cb16-89"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb16-90"><a href="#cb16-90"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb16-91"><a href="#cb16-91"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>  <span class="fu">append_topleft</span>(<span class="st">"Logistic regression with interaction"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-93"><a href="#cb16-93"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb16-94"><a href="#cb16-94"></a>result</span>
+<span id="cb16-95"><a href="#cb16-95"></a><span class="in">```</span></span>
+<span id="cb16-96"><a href="#cb16-96"></a></span>
+<span id="cb16-97"><a href="#cb16-97"></a><span class="fu">## Multi-Variable Logistic Regression &lt;br/&gt; Specifying Covariates</span></span>
+<span id="cb16-98"><a href="#cb16-98"></a></span>
+<span id="cb16-99"><a href="#cb16-99"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-100"><a href="#cb16-100"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb16-101"><a href="#cb16-101"></a>  adrs,</span>
+<span id="cb16-102"><a href="#cb16-102"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-103"><a href="#cb16-103"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb16-104"><a href="#cb16-104"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb16-105"><a href="#cb16-105"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>, <span class="st">"RACE"</span>)</span>
+<span id="cb16-106"><a href="#cb16-106"></a>  )</span>
+<span id="cb16-107"><a href="#cb16-107"></a>)</span>
+<span id="cb16-108"><a href="#cb16-108"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.95</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level)</span>
+<span id="cb16-110"><a href="#cb16-110"></a></span>
+<span id="cb16-111"><a href="#cb16-111"></a><span class="co"># empty string flag</span></span>
+<span id="cb16-112"><a href="#cb16-112"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb16-113"><a href="#cb16-113"></a></span>
+<span id="cb16-114"><a href="#cb16-114"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-115"><a href="#cb16-115"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb16-116"><a href="#cb16-116"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb16-117"><a href="#cb16-117"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb16-118"><a href="#cb16-118"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-119"><a href="#cb16-119"></a>  <span class="fu">append_topleft</span>(<span class="st">"y ~ ARM + SEX + AGE + RACE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-120"><a href="#cb16-120"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb16-121"><a href="#cb16-121"></a>result</span>
+<span id="cb16-122"><a href="#cb16-122"></a><span class="in">```</span></span>
+<span id="cb16-123"><a href="#cb16-123"></a></span>
+<span id="cb16-124"><a href="#cb16-124"></a><span class="fu">## Multi-Variable Logistic Regression Setting &lt;br/&gt; an Event, Alpha Level, and Level for Interaction</span></span>
+<span id="cb16-125"><a href="#cb16-125"></a></span>
+<span id="cb16-126"><a href="#cb16-126"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-127"><a href="#cb16-127"></a>model <span class="ot">&lt;-</span> <span class="fu">fit_logistic</span>(</span>
+<span id="cb16-128"><a href="#cb16-128"></a>  adrs,</span>
+<span id="cb16-129"><a href="#cb16-129"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-130"><a href="#cb16-130"></a>    <span class="at">response =</span> <span class="st">"Response"</span>,</span>
+<span id="cb16-131"><a href="#cb16-131"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb16-132"><a href="#cb16-132"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>),</span>
+<span id="cb16-133"><a href="#cb16-133"></a>    <span class="at">interaction =</span> <span class="st">"AGE"</span></span>
+<span id="cb16-134"><a href="#cb16-134"></a>  ),</span>
+<span id="cb16-135"><a href="#cb16-135"></a>  <span class="at">response_definition =</span> <span class="st">"1 - response"</span></span>
+<span id="cb16-136"><a href="#cb16-136"></a>)</span>
+<span id="cb16-137"><a href="#cb16-137"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.9</span></span>
+<span id="cb16-138"><a href="#cb16-138"></a>df <span class="ot">&lt;-</span> broom<span class="sc">::</span><span class="fu">tidy</span>(model, <span class="at">conf_level =</span> conf_level, <span class="at">at =</span> <span class="fu">c</span>(<span class="dv">30</span>, <span class="dv">50</span>))</span>
+<span id="cb16-139"><a href="#cb16-139"></a></span>
+<span id="cb16-140"><a href="#cb16-140"></a><span class="co"># empty string flag</span></span>
+<span id="cb16-141"><a href="#cb16-141"></a>df <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(df, <span class="at">na_level =</span> <span class="st">"_NA_"</span>)</span>
+<span id="cb16-142"><a href="#cb16-142"></a></span>
+<span id="cb16-143"><a href="#cb16-143"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-144"><a href="#cb16-144"></a>  <span class="fu">summarize_logistic</span>(</span>
+<span id="cb16-145"><a href="#cb16-145"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb16-146"><a href="#cb16-146"></a>    <span class="at">drop_and_remove_str =</span> <span class="st">"_NA_"</span></span>
+<span id="cb16-147"><a href="#cb16-147"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-148"><a href="#cb16-148"></a>  <span class="fu">append_topleft</span>(<span class="st">"Estimations at age 30 and 50"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-149"><a href="#cb16-149"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df)</span>
+<span id="cb16-150"><a href="#cb16-150"></a>result</span>
+<span id="cb16-151"><a href="#cb16-151"></a><span class="in">```</span></span>
+<span id="cb16-152"><a href="#cb16-152"></a></span>
+<span id="cb16-153"><a href="#cb16-153"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-154"><a href="#cb16-154"></a></span>
+<span id="cb16-155"><a href="#cb16-155"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-156"><a href="#cb16-156"></a></span>
+<span id="cb16-157"><a href="#cb16-157"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb16-159"><a href="#cb16-159"></a></span>
+<span id="cb16-160"><a href="#cb16-160"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-161"><a href="#cb16-161"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-162"><a href="#cb16-162"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-163"><a href="#cb16-163"></a></span>
+<span id="cb16-164"><a href="#cb16-164"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-165"><a href="#cb16-165"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BESRSPI"</span>, <span class="st">"INVET"</span>))</span>
+<span id="cb16-167"><a href="#cb16-167"></a></span>
+<span id="cb16-168"><a href="#cb16-168"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-169"><a href="#cb16-169"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb16-170"><a href="#cb16-170"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb16-171"><a href="#cb16-171"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb16-172"><a href="#cb16-172"></a>  ),</span>
+<span id="cb16-173"><a href="#cb16-173"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb16-174"><a href="#cb16-174"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb16-175"><a href="#cb16-175"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb16-176"><a href="#cb16-176"></a>  )</span>
+<span id="cb16-177"><a href="#cb16-177"></a>)</span>
+<span id="cb16-178"><a href="#cb16-178"></a></span>
+<span id="cb16-179"><a href="#cb16-179"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-180"><a href="#cb16-180"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-181"><a href="#cb16-181"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, ADSL, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb16-182"><a href="#cb16-182"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb16-183"><a href="#cb16-183"></a>      <span class="st">"ADRS"</span>, ADRS,</span>
+<span id="cb16-184"><a href="#cb16-184"></a>      <span class="at">code =</span> <span class="st">'ADRS &lt;- synthetic_cdisc_dataset("latest", "adrs") %&gt;% filter(PARAMCD %in% c("BESRSPI", "INVET"))'</span></span>
+<span id="cb16-185"><a href="#cb16-185"></a>    ),</span>
+<span id="cb16-186"><a href="#cb16-186"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-187"><a href="#cb16-187"></a>  ),</span>
+<span id="cb16-188"><a href="#cb16-188"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-189"><a href="#cb16-189"></a>    <span class="fu">tm_t_logistic</span>(</span>
+<span id="cb16-190"><a href="#cb16-190"></a>      <span class="at">label =</span> <span class="st">"Logistic Regression"</span>,</span>
+<span id="cb16-191"><a href="#cb16-191"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb16-192"><a href="#cb16-192"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-193"><a href="#cb16-193"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb16-194"><a href="#cb16-194"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb16-195"><a href="#cb16-195"></a>      ),</span>
+<span id="cb16-196"><a href="#cb16-196"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb16-197"><a href="#cb16-197"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-198"><a href="#cb16-198"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb16-199"><a href="#cb16-199"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb16-200"><a href="#cb16-200"></a>      ),</span>
+<span id="cb16-201"><a href="#cb16-201"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-202"><a href="#cb16-202"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"AGE"</span>, <span class="st">"BMRKR1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb16-203"><a href="#cb16-203"></a>        <span class="at">selected =</span> <span class="st">"SEX"</span></span>
+<span id="cb16-204"><a href="#cb16-204"></a>      )</span>
+<span id="cb16-205"><a href="#cb16-205"></a>    )</span>
+<span id="cb16-206"><a href="#cb16-206"></a>  )</span>
+<span id="cb16-207"><a href="#cb16-207"></a>)</span>
+<span id="cb16-208"><a href="#cb16-208"></a></span>
+<span id="cb16-209"><a href="#cb16-209"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-210"><a href="#cb16-210"></a><span class="in">```</span></span>
+<span id="cb16-211"><a href="#cb16-211"></a></span>
+<span id="cb16-212"><a href="#cb16-212"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-213"><a href="#cb16-213"></a></span>
+<span id="cb16-214"><a href="#cb16-214"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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\ No newline at end of file
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - MMRMT01</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
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+div.sourceCode { margin: 1em 0; }
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+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
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+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
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+div.sourceCode
+  {   }
+@media screen {
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+}
+</style>
+
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+<meta name="quarto:offset" content="../../">
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+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
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+      </div>
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
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+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MMRMT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Tables for Mixed-Effect Model Repeated Measures Analysis</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Least Squares Means</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Fixed Effects</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Covariance Matrix</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Model Diagnostics</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mmrmt01_cache/html/setup_c3f6401b26e3f72a644648bdeff854a1">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(broom)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"SCREENING"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">factor</span>(ARMCD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>      <span class="fu">as.factor</span>()</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  )</span>
+<span id="cb1-23"><a href="#cb1-23"></a>adsl_sub <span class="ot">&lt;-</span> adqs_f <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(CHG)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">left_join</span>(adsl, <span class="at">by =</span> <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-27"><a href="#cb1-27"></a><span class="fu">var_labels</span>(adqs_f) <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adqs)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<section id="considering-the-treatment-variable-in-the-model" class="level3"><h3 class="anchored" data-anchor-id="considering-the-treatment-variable-in-the-model">Considering the treatment variable in the model</h3>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="mmrmt01_cache/html/variant1_5214d938edc27cdafc1b5d9da7aaadd4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Warning: "automatic" optimizer was deprecated in mmrm 0.2.0.
+ℹ please just omit optimizer argument
+ℹ The deprecated feature was likely used in the mmrm package.
+  Please report the issue at &lt;https://github.com/openpharma/mmrm/issues&gt;.</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>df <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">attr</span>(df<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="co"># Define the split function</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">build_table</span>(df, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                                      ARM B              ARM A              ARM C      
+  Statistics                              (N=134)            (N=134)            (N=132)     
+————————————————————————————————————————————————————————————————————————————————————————————
+WEEK 1 DAY 8                                                                                
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  
+    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) 
+  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) 
+    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) 
+    Relative Increase (%)                                     21.8%              -9.3%      
+    p-value (MMRM)                                            0.4362             0.7393     
+WEEK 2 DAY 15                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  
+    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) 
+  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) 
+    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) 
+    Relative Increase (%)                                     -1.3%              -6.8%      
+    p-value (MMRM)                                            0.9147             0.5662     
+WEEK 3 DAY 22                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) 
+    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)
+  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  
+    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) 
+    Relative Increase (%)                                     18.2%              16.6%      
+    p-value (MMRM)                                            0.0460             0.0704     
+WEEK 4 DAY 29                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) 
+    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)
+  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  
+    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) 
+    Relative Increase (%)                                      7.6%               7.8%      
+    p-value (MMRM)                                            0.3288             0.3192     
+WEEK 5 DAY 36                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) 
+    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)
+  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  
+    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) 
+    Relative Increase (%)                                      6.1%               0.9%      
+    p-value (MMRM)                                            0.3408             0.8937     </code></pre>
+</div>
+</div>
+</section><section id="not-considering-the-treatment-variable-in-the-model" class="level3"><h3 class="anchored" data-anchor-id="not-considering-the-treatment-variable-in-the-model">Not considering the treatment variable in the model</h3>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="mmrmt01_cache/html/variant2_91826f4a5611a11fe8e15c2ee2b937f8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>mmrm_results_no_arm <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb6-3"><a href="#cb6-3"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BMRKR2"</span>, <span class="st">"STRATA1"</span>),</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  ),</span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="at">parallel =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stderr">
+<pre><code>Warning: `free_cores()` was deprecated in mmrm 0.1.6.
+ℹ Please use the `omit` argument of `parallelly::availableCores()` instead.
+ℹ The deprecated feature was likely used in the tern.mmrm package.
+  Please report the issue at
+  &lt;https://github.com/insightsengineering/tern.mmrm/issues&gt;.</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>df_no_arm <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results_no_arm)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">attr</span>(df_no_arm<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co"># Define the split function</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df_no_arm<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">arms =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>  <span class="fu">build_table</span>(df_no_arm, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb8-13"><a href="#cb8-13"></a></span>
+<span id="cb8-14"><a href="#cb8-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                    All Patients  
+  Statistics               (N=400)     
+———————————————————————————————————————
+WEEK 1 DAY 8                           
+  n                          400       
+  Adjusted Mean (SE)    3.615 (0.620)  
+    95% CI              (2.396, 4.834) 
+WEEK 2 DAY 15                          
+  n                          400       
+  Adjusted Mean (SE)    8.870 (0.602)  
+    95% CI             (7.687, 10.053) 
+WEEK 3 DAY 22                          
+  n                          400       
+  Adjusted Mean (SE)    15.094 (0.683) 
+    95% CI             (13.751, 16.437)
+WEEK 4 DAY 29                          
+  n                          400       
+  Adjusted Mean (SE)    19.009 (0.717) 
+    95% CI             (17.599, 20.418)
+WEEK 5 DAY 36                          
+  n                          400       
+  Adjusted Mean (SE)    24.028 (0.747) 
+    95% CI             (22.560, 25.496)</code></pre>
+</div>
+</div>
+</section><section id="adding-baseline-rows" class="level3"><h3 class="anchored" data-anchor-id="adding-baseline-rows">Adding baseline rows</h3>
+<p>It may be of interest to summarize some different statistics at the baseline visit or summarize a different variable in the data set not used in the MMRM. For example, the model may use the variable <code>CHG</code> but the baseline visit row may summarize the <code>AVAL</code> variable, thus we would need to create two tables and then combine them to accomplish this.</p>
+<div class="cell" data-hash="mmrmt01_cache/html/unnamed-chunk-1_0e3dfb7d655c930aa79518151d095686">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># First have the least-square means table.</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>a <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-6"><a href="#cb10-6"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>  <span class="fu">build_table</span>(df, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb10-8"><a href="#cb10-8"></a></span>
+<span id="cb10-9"><a href="#cb10-9"></a><span class="co"># Second prepare the baseline values summary table.</span></span>
+<span id="cb10-10"><a href="#cb10-10"></a>baseline_dat <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb10-13"><a href="#cb10-13"></a></span>
+<span id="cb10-14"><a href="#cb10-14"></a>b <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a>  <span class="fu">analyze_vars</span>(<span class="st">"AVAL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-19"><a href="#cb10-19"></a>  <span class="fu">build_table</span>(baseline_dat, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb10-20"><a href="#cb10-20"></a></span>
+<span id="cb10-21"><a href="#cb10-21"></a><span class="co"># Now we can combine them as follows.</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a><span class="fu">col_info</span>(b) <span class="ot">&lt;-</span> EmptyColInfo</span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="fu">rbind</span>(b, a)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                                      ARM B              ARM A              ARM C      
+  Statistics                              (N=134)            (N=134)            (N=132)     
+————————————————————————————————————————————————————————————————————————————————————————————
+BASELINE                                                                                    
+  n                                         670                670                660       
+  Mean (SD)                              49.8 (8.1)         50.4 (8.3)         50.2 (8.4)   
+  Median                                    49.6               50.2               50.4      
+  Min - Max                             24.3 - 72.9        21.7 - 74.5        26.0 - 71.4   
+WEEK 1 DAY 8                                                                                
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  
+    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) 
+  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) 
+    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) 
+    Relative Increase (%)                                     21.8%              -9.3%      
+    p-value (MMRM)                                            0.4362             0.7393     
+WEEK 2 DAY 15                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  
+    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) 
+  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) 
+    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) 
+    Relative Increase (%)                                     -1.3%              -6.8%      
+    p-value (MMRM)                                            0.9147             0.5662     
+WEEK 3 DAY 22                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) 
+    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)
+  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  
+    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) 
+    Relative Increase (%)                                     18.2%              16.6%      
+    p-value (MMRM)                                            0.0460             0.0704     
+WEEK 4 DAY 29                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) 
+    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)
+  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  
+    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) 
+    Relative Increase (%)                                      7.6%               7.8%      
+    p-value (MMRM)                                            0.3288             0.3192     
+WEEK 5 DAY 36                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) 
+    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)
+  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  
+    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) 
+    Relative Increase (%)                                      6.1%               0.9%      
+    p-value (MMRM)                                            0.3408             0.8937     </code></pre>
+</div>
+</div>
+</section><section id="considering-visit-averages" class="level3"><h3 class="anchored" data-anchor-id="considering-visit-averages">Considering visit averages</h3>
+<p>It may also be of interest to summarize several different statistics for an averaged combination of various visits in the MMRM. For example, you may want to see the statistics for the average of the first 2 visits, or the average statistics of all visits combined. This can be accomplished by specifying the <code>averages_emmeans</code> argument when fitting the MMRM model.</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="mmrmt01_cache/html/variant3_5297bc0be3b57f81c1ce6c065ed0a21c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>mmrm_results_avg_visits <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb12-2"><a href="#cb12-2"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb12-3"><a href="#cb12-3"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb12-4"><a href="#cb12-4"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb12-5"><a href="#cb12-5"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb12-6"><a href="#cb12-6"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb12-7"><a href="#cb12-7"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb12-8"><a href="#cb12-8"></a>  ),</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb12-10"><a href="#cb12-10"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb12-11"><a href="#cb12-11"></a>  <span class="at">averages_emmeans =</span> <span class="fu">list</span>(</span>
+<span id="cb12-12"><a href="#cb12-12"></a>    <span class="st">"WEEKS 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>),</span>
+<span id="cb12-13"><a href="#cb12-13"></a>    <span class="st">"WEEKS 3-5"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>, <span class="st">"WEEK 5 DAY 36"</span>),</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="st">"ALL VISITS"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>, <span class="st">"WEEK 5 DAY 36"</span>)</span>
+<span id="cb12-15"><a href="#cb12-15"></a>  )</span>
+<span id="cb12-16"><a href="#cb12-16"></a>)</span>
+<span id="cb12-17"><a href="#cb12-17"></a></span>
+<span id="cb12-18"><a href="#cb12-18"></a>df_avgs <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results_avg_visits)</span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="fu">attr</span>(df_avgs<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb12-20"><a href="#cb12-20"></a></span>
+<span id="cb12-21"><a href="#cb12-21"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-22"><a href="#cb12-22"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-23"><a href="#cb12-23"></a></span>
+<span id="cb12-24"><a href="#cb12-24"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-25"><a href="#cb12-25"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results_avg_visits<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb12-26"><a href="#cb12-26"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df_avgs<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>  <span class="fu">build_table</span>(df_avgs, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb12-30"><a href="#cb12-30"></a></span>
+<span id="cb12-31"><a href="#cb12-31"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                                      ARM B              ARM A              ARM C      
+  Statistics                              (N=134)            (N=134)            (N=132)     
+————————————————————————————————————————————————————————————————————————————————————————————
+WEEK 1 DAY 8                                                                                
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   3.488 (0.687)      4.246 (0.687)      3.163 (0.692)  
+    95% CI                             (2.136, 4.839)     (2.895, 5.598)     (1.803, 4.523) 
+  Difference in Adjusted Means (SE)                       0.759 (0.973)      -0.325 (0.976) 
+    95% CI                                               (-1.155, 2.672)    (-2.243, 1.593) 
+    Relative Increase (%)                                     21.8%              -9.3%      
+    p-value (MMRM)                                            0.4362             0.7393     
+WEEK 2 DAY 15                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   9.135 (0.768)      9.018 (0.767)      8.509 (0.773)  
+    95% CI                            (7.626, 10.644)    (7.510, 10.527)    (6.991, 10.028) 
+  Difference in Adjusted Means (SE)                       -0.117 (1.087)     -0.626 (1.090) 
+    95% CI                                               (-2.253, 2.020)    (-2.768, 1.517) 
+    Relative Increase (%)                                     -1.3%              -6.8%      
+    p-value (MMRM)                                            0.9147             0.5662     
+WEEK 3 DAY 22                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   13.547 (0.871)     16.014 (0.871)     15.789 (0.877) 
+    95% CI                            (11.835, 15.259)   (14.303, 17.726)   (14.066, 17.513)
+  Difference in Adjusted Means (SE)                       2.467 (1.232)      2.242 (1.236)  
+    95% CI                                                (0.044, 4.890)    (-0.187, 4.672) 
+    Relative Increase (%)                                     18.2%              16.6%      
+    p-value (MMRM)                                            0.0460             0.0704     
+WEEK 4 DAY 29                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   18.102 (0.995)     19.479 (0.995)     19.511 (1.002) 
+    95% CI                            (16.146, 20.059)   (17.523, 21.435)   (17.541, 21.481)
+  Difference in Adjusted Means (SE)                       1.377 (1.408)      1.409 (1.413)  
+    95% CI                                               (-1.392, 4.145)    (-1.368, 4.186) 
+    Relative Increase (%)                                      7.6%               7.8%      
+    p-value (MMRM)                                            0.3288             0.3192     
+WEEK 5 DAY 36                                                                               
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   23.503 (1.058)     24.931 (1.058)     23.704 (1.065) 
+    95% CI                            (21.423, 25.583)   (22.851, 27.011)   (21.610, 25.798)
+  Difference in Adjusted Means (SE)                       1.428 (1.497)      0.201 (1.502)  
+    95% CI                                               (-1.515, 4.371)    (-2.752, 3.153) 
+    Relative Increase (%)                                      6.1%               0.9%      
+    p-value (MMRM)                                            0.3408             0.8937     
+WEEKS 1-2                                                                                   
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   6.311 (0.514)      6.632 (0.514)      5.836 (0.516)  
+    95% CI                             (5.301, 7.322)     (5.623, 7.642)     (4.821, 6.852) 
+  Difference in Adjusted Means (SE)                       0.321 (0.728)      -0.475 (0.729) 
+    95% CI                                               (-1.111, 1.753)    (-1.909, 0.959) 
+    Relative Increase (%)                                      5.1%              -7.5%      
+    p-value (MMRM)                                            0.6596             0.5151     
+WEEKS 3-5                                                                                   
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   18.384 (0.560)     20.141 (0.560)     19.668 (0.563) 
+    95% CI                            (17.284, 19.485)   (19.041, 21.241)   (18.562, 20.775)
+  Difference in Adjusted Means (SE)                       1.757 (0.793)      1.284 (0.794)  
+    95% CI                                                (0.198, 3.316)    (-0.278, 2.846) 
+    Relative Increase (%)                                      9.6%               7.0%      
+    p-value (MMRM)                                            0.0273             0.1068     
+ALL VISITS                                                                                  
+  n                                         134                134                132       
+  Adjusted Mean (SE)                   13.555 (0.388)     14.738 (0.388)     14.135 (0.389) 
+    95% CI                            (12.792, 14.318)   (13.976, 15.500)   (13.370, 14.900)
+  Difference in Adjusted Means (SE)                       1.183 (0.551)      0.580 (0.551)  
+    95% CI                                                (0.100, 2.266)    (-0.502, 1.663) 
+    Relative Increase (%)                                      8.7%               4.3%      
+    p-value (MMRM)                                            0.0324             0.2924     </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="considering-the-treatment-variable-in-the-model-1" class="level4"><h4 class="anchored" data-anchor-id="considering-the-treatment-variable-in-the-model-1">Considering the treatment variable in the model</h4>
+<div class="cell" data-hash="mmrmt01_cache/html/unnamed-chunk-2_0bd9a81f8a774f3744b94bec963e23d7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"fixed"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                 Estimate   Std. Error   t value    df    Pr(&gt;|t|)
+——————————————————————————————————————————————————————————————————————————————————
+(Intercept)                      55.7483      1.5244     36.5713    510   &lt;0.0001 
+BASE                             -1.0196      0.0246     -41.4362   392   &lt;0.0001 
+STRATA1B                         -0.0369      0.5345     -0.0691    392    0.9450 
+STRATA1C                          0.0205      0.5238      0.0392    392    0.9688 
+BMRKR2MEDIUM                     -0.3840      0.5198     -0.7386    392    0.4606 
+BMRKR2HIGH                       -1.0056      0.5259     -1.9123    392    0.0566 
+ARMCDARM A                        0.7587      0.9733      0.7795    396    0.4362 
+ARMCDARM C                       -0.3248      0.9756     -0.3329    394    0.7393 
+AVISITWEEK 2 DAY 15               5.6472      1.0331      5.4665    397   &lt;0.0001 
+AVISITWEEK 3 DAY 22              10.0591      1.0897      9.2311    397   &lt;0.0001 
+AVISITWEEK 4 DAY 29              14.6145      1.2176     12.0027    397   &lt;0.0001 
+AVISITWEEK 5 DAY 36              20.0154      1.2584     15.9057    397   &lt;0.0001 
+ARMCDARM A:AVISITWEEK 2 DAY 15   -0.8752      1.4610     -0.5990    397    0.5495 
+ARMCDARM C:AVISITWEEK 2 DAY 15   -0.3007      1.4665     -0.2050    397    0.8376 
+ARMCDARM A:AVISITWEEK 3 DAY 22    1.7085      1.5411      1.1087    397    0.2682 
+ARMCDARM C:AVISITWEEK 3 DAY 22    2.5673      1.5469      1.6597    397    0.0978 
+ARMCDARM A:AVISITWEEK 4 DAY 29    0.6181      1.7220      0.3589    397    0.7198 
+ARMCDARM C:AVISITWEEK 4 DAY 29    1.7337      1.7285      1.0030    397    0.3165 
+ARMCDARM A:AVISITWEEK 5 DAY 36    0.6690      1.7796      0.3759    397    0.7072 
+ARMCDARM C:AVISITWEEK 5 DAY 36    0.5257      1.7863      0.2943    397    0.7687 </code></pre>
+</div>
+</div>
+</section><section id="not-considering-the-treatment-variable-in-the-model-1" class="level4"><h4 class="anchored" data-anchor-id="not-considering-the-treatment-variable-in-the-model-1">Not considering the treatment variable in the model</h4>
+<div class="cell" data-hash="mmrmt01_cache/html/unnamed-chunk-3_741b155218e8733c3f20aac5521db782">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a><span class="fu">as.rtable</span>(mmrm_results_no_arm, <span class="at">type =</span> <span class="st">"fixed"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                      Estimate   Std. Error   t value   df    Pr(&gt;|t|)
+——————————————————————————————————————————————————————————————————————
+(Intercept)            1.5624      1.1751     1.3296    466    0.1843 
+BMRKR2MEDIUM           1.0924      1.1878     0.9196    395    0.3583 
+BMRKR2HIGH             1.4619      1.1971     1.2212    395    0.2227 
+STRATA1B               2.6321      1.2180     2.1610    395    0.0313 
+STRATA1C               0.9717      1.2008     0.8092    395    0.4189 
+AVISITWEEK 2 DAY 15    5.2548      0.5967     8.8061    399   &lt;0.0001 
+AVISITWEEK 3 DAY 22   11.4787      0.6314     18.1802   399   &lt;0.0001 
+AVISITWEEK 4 DAY 29   15.3937      0.7039     21.8696   399   &lt;0.0001 
+AVISITWEEK 5 DAY 36   20.4130      0.7266     28.0921   399   &lt;0.0001 </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-hash="mmrmt01_cache/html/unnamed-chunk-4_45dab418e42dffe1ff32f4330f817560">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"cov"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                WEEK 1 DAY 8   WEEK 2 DAY 15   WEEK 3 DAY 22   WEEK 4 DAY 29   WEEK 5 DAY 36
+————————————————————————————————————————————————————————————————————————————————————————————
+WEEK 1 DAY 8      63.0140         -0.6664         2.5965          -1.6231         0.2589    
+WEEK 2 DAY 15     -0.6664         78.6592         1.7004         -11.8677         -0.4261   
+WEEK 3 DAY 22      2.5965         1.7004         101.2949         -5.8424         7.1145    
+WEEK 4 DAY 29     -1.6231        -11.8677         -5.8424        132.4034         -5.3739   
+WEEK 5 DAY 36      0.2589         -0.4261         7.1145          -5.3739        149.6937   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Model diagnostics are currently available to evaluate choice of covariates for the fixed and random effects. Statistics to evaluate choice of covariance structure are being investigated and will be included in a future release.</p>
+<div class="cell" data-hash="mmrmt01_cache/html/unnamed-chunk-5_2052440b5ad038985e3d7864f66abf7a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb20"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb20-1"><a href="#cb20-1"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"diagnostic"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                 Diagnostic statistic value
+———————————————————————————————————————————
+REML criterion           14835.9968        
+AIC                      14865.9968        
+AICc                     14866.2412        
+BIC                      14925.8688        </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:24}" data-hash="mmrmt01_cache/html/teal_25903afb40c32569ba24ef8c63803377">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb22"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb22-1"><a href="#cb22-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb22-2"><a href="#cb22-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb22-3"><a href="#cb22-3"></a></span>
+<span id="cb22-4"><a href="#cb22-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb22-5"><a href="#cb22-5"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-6"><a href="#cb22-6"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb22-7"><a href="#cb22-7"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb22-8"><a href="#cb22-8"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb22-9"><a href="#cb22-9"></a>    <span class="at">AVISIT =</span> <span class="fu">as.factor</span>(AVISIT),</span>
+<span id="cb22-10"><a href="#cb22-10"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb22-11"><a href="#cb22-11"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb22-12"><a href="#cb22-12"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb22-13"><a href="#cb22-13"></a>      <span class="fu">as.factor</span>() <span class="co"># making consecutive numeric factor</span></span>
+<span id="cb22-14"><a href="#cb22-14"></a>  )</span>
+<span id="cb22-15"><a href="#cb22-15"></a></span>
+<span id="cb22-16"><a href="#cb22-16"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb22-17"><a href="#cb22-17"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb22-18"><a href="#cb22-18"></a>    <span class="at">ref =</span> <span class="st">"ARM A"</span>,</span>
+<span id="cb22-19"><a href="#cb22-19"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb22-20"><a href="#cb22-20"></a>  )</span>
+<span id="cb22-21"><a href="#cb22-21"></a>)</span>
+<span id="cb22-22"><a href="#cb22-22"></a></span>
+<span id="cb22-23"><a href="#cb22-23"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb22-24"><a href="#cb22-24"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb22-25"><a href="#cb22-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb22-26"><a href="#cb22-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs,</span>
+<span id="cb22-27"><a href="#cb22-27"></a>      <span class="at">code =</span> <span class="st">'ADQS &lt;- synthetic_cdisc_dataset("latest", "adqs") %&gt;%</span></span>
+<span id="cb22-28"><a href="#cb22-28"></a><span class="st">              dplyr::filter(ABLFL != "Y" &amp; ABLFL2 != "Y") %&gt;%</span></span>
+<span id="cb22-29"><a href="#cb22-29"></a><span class="st">              dplyr::filter(AVISIT %in% c("WEEK 1 DAY 8", "WEEK 2 DAY 15", "WEEK 3 DAY 22")) %&gt;%</span></span>
+<span id="cb22-30"><a href="#cb22-30"></a><span class="st">              dplyr::mutate(</span></span>
+<span id="cb22-31"><a href="#cb22-31"></a><span class="st">                AVISIT = as.factor(AVISIT),</span></span>
+<span id="cb22-32"><a href="#cb22-32"></a><span class="st">                AVISITN = rank(AVISITN) %&gt;%</span></span>
+<span id="cb22-33"><a href="#cb22-33"></a><span class="st">                  as.factor() %&gt;%</span></span>
+<span id="cb22-34"><a href="#cb22-34"></a><span class="st">                  as.numeric() %&gt;%</span></span>
+<span id="cb22-35"><a href="#cb22-35"></a><span class="st">                  as.factor() # making consecutive numeric factor</span></span>
+<span id="cb22-36"><a href="#cb22-36"></a><span class="st">              )'</span></span>
+<span id="cb22-37"><a href="#cb22-37"></a>    ),</span>
+<span id="cb22-38"><a href="#cb22-38"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb22-39"><a href="#cb22-39"></a>  ),</span>
+<span id="cb22-40"><a href="#cb22-40"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb22-41"><a href="#cb22-41"></a>    <span class="fu">tm_a_mmrm</span>(</span>
+<span id="cb22-42"><a href="#cb22-42"></a>      <span class="at">label =</span> <span class="st">"MMRM"</span>,</span>
+<span id="cb22-43"><a href="#cb22-43"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb22-44"><a href="#cb22-44"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>), <span class="st">"CHG"</span>),</span>
+<span id="cb22-45"><a href="#cb22-45"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"SUBJID"</span>), <span class="st">"USUBJID"</span>),</span>
+<span id="cb22-46"><a href="#cb22-46"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARMCD"</span>),</span>
+<span id="cb22-47"><a href="#cb22-47"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"AVISITN"</span>), <span class="st">"AVISIT"</span>),</span>
+<span id="cb22-48"><a href="#cb22-48"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb22-49"><a href="#cb22-49"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb22-50"><a href="#cb22-50"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb22-51"><a href="#cb22-51"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb22-52"><a href="#cb22-52"></a>      ),</span>
+<span id="cb22-53"><a href="#cb22-53"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"BASE:AVISIT"</span>), <span class="cn">NULL</span>),</span>
+<span id="cb22-54"><a href="#cb22-54"></a>      <span class="at">conf_level =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="fl">0.95</span>, <span class="fl">0.9</span>, <span class="fl">0.8</span>), <span class="fl">0.95</span>)</span>
+<span id="cb22-55"><a href="#cb22-55"></a>    )</span>
+<span id="cb22-56"><a href="#cb22-56"></a>  )</span>
+<span id="cb22-57"><a href="#cb22-57"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:57:17.7265 pid:7260 token:[] teal.modules.clinical Initializing tm_a_mmrm</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb24"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb24-1"><a href="#cb24-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mmrmt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mmrmt01_cache/html/sessioninfo_d89cbbc30756259cb09342b381f61f74">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb25"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb25-1"><a href="#cb25-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] broom_1.0.5                  scda_0.1.6                  
+ [9] tern.mmrm_0.2.1              tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] Rdpack_2.5            mmrm_0.2.2            tern.gee_0.1.0       
+ [4] logger_0.2.2          testthat_3.1.10       sandwich_3.0-2       
+ [7] rlang_1.1.1           multcomp_1.4-25       compiler_4.3.1       
+[10] callr_3.7.3           vctrs_0.6.3           stringr_1.5.0        
+[13] pkgconfig_2.0.3       fastmap_1.1.1         backports_1.4.1      
+[16] ellipsis_0.3.2        fontawesome_0.5.2     utf8_1.2.3           
+[19] promises_1.2.1        rmarkdown_2.25        ps_1.7.5             
+[22] purrr_1.0.2           xfun_0.40             cachem_1.0.8         
+[25] teal.reporter_0.2.1   jsonlite_1.8.7        later_1.3.1          
+[28] parallel_4.3.1        R6_2.5.1              bslib_0.5.1          
+[31] stringi_1.7.12        brio_1.1.3            jquerylib_0.1.4      
+[34] numDeriv_2016.8-1.1   estimability_1.4.1    Rcpp_1.0.11          
+[37] assertthat_0.2.1      knitr_1.44            zoo_1.8-12           
+[40] teal.logger_0.1.3     httpuv_1.6.11         Matrix_1.6-1.1       
+[43] splines_4.3.1         tidyselect_1.2.0      rstudioapi_0.15.0    
+[46] yaml_2.3.7            TMB_1.9.6             codetools_0.2-19     
+[49] processx_3.8.2        teal.widgets_0.4.0    lattice_0.21-8       
+[52] tibble_3.2.1          withr_2.5.0           coda_0.19-4          
+[55] evaluate_0.21         survival_3.5-7        pillar_1.9.0         
+[58] shinycssloaders_1.0.0 checkmate_2.2.0       shinyjs_2.1.0        
+[61] generics_0.1.3        ggplot2_3.4.3         munsell_0.5.0        
+[64] scales_1.2.1          xtable_1.8-4          glue_1.6.2           
+[67] emmeans_1.8.8         tools_4.3.1           webshot_0.5.5        
+[70] forcats_1.0.0         mvtnorm_1.2-3         cowplot_1.1.1        
+[73] grid_4.3.1            tidyr_1.3.0           rbibutils_2.2.15     
+[76] colorspace_2.1-0      nlme_3.1-163          cli_3.6.1            
+[79] fansi_1.0.4           geepack_1.3.9         gtable_0.3.4         
+[82] sass_0.4.7            digest_0.6.33         TH.data_1.1-2        
+[85] htmlwidgets_1.6.2     memoise_2.0.1         htmltools_0.5.6      
+[88] lifecycle_1.0.3       shinyWidgets_0.8.0    mime_0.12            
+[91] MASS_7.3-60          </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mmrmt01_cache/html/snapshot_64b8fd70e14bb068a9e3d22acfaf0ee9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb27"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb27-1"><a href="#cb27-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb27-2"><a href="#cb27-2"></a></span>
+<span id="cb27-3"><a href="#cb27-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb27-4"><a href="#cb27-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb27-5"><a href="#cb27-5"></a></span>
+<span id="cb27-6"><a href="#cb27-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb27-7"><a href="#cb27-7"></a></span>
+<span id="cb27-8"><a href="#cb27-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb27-9"><a href="#cb27-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb27-10"><a href="#cb27-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb27-11"><a href="#cb27-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/mmrmt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
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+  }
+  toggleBodyColorPrimary();  
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+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
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+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
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+      } else {
+        el.classList.add('notransition');
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+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
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+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
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+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
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+          toggle.classList.add("alternate");     
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+          toggle.classList.remove("alternate");
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+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
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+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
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+      return storageValue != null ? storageValue : localAlternateSentinel;
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+  // Dark / light mode switch
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+    // Read the current dark / light value 
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+    toggleColorMode(toAlternate);
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+<div class="sourceCode" id="cb28" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb28-1"><a href="#cb28-1"></a><span class="co">---</span></span>
+<span id="cb28-2"><a href="#cb28-2"></a><span class="an">title:</span><span class="co"> MMRMT01</span></span>
+<span id="cb28-3"><a href="#cb28-3"></a><span class="an">subtitle:</span><span class="co"> Tables for Mixed-Effect Model Repeated Measures Analysis</span></span>
+<span id="cb28-4"><a href="#cb28-4"></a><span class="co">---</span></span>
+<span id="cb28-5"><a href="#cb28-5"></a></span>
+<span id="cb28-6"><a href="#cb28-6"></a>------------------------------------------------------------------------</span>
+<span id="cb28-7"><a href="#cb28-7"></a></span>
+<span id="cb28-8"><a href="#cb28-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb28-9"><a href="#cb28-9"></a></span>
+<span id="cb28-10"><a href="#cb28-10"></a>::: panel-tabset</span>
+<span id="cb28-11"><a href="#cb28-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb28-12"><a href="#cb28-12"></a></span>
+<span id="cb28-13"><a href="#cb28-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb28-14"><a href="#cb28-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb28-15"><a href="#cb28-15"></a></span>
+<span id="cb28-16"><a href="#cb28-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb28-17"><a href="#cb28-17"></a><span class="fu">library</span>(tern.mmrm)</span>
+<span id="cb28-18"><a href="#cb28-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb28-19"><a href="#cb28-19"></a><span class="fu">library</span>(broom)</span>
+<span id="cb28-20"><a href="#cb28-20"></a></span>
+<span id="cb28-21"><a href="#cb28-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb28-22"><a href="#cb28-22"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>)</span>
+<span id="cb28-23"><a href="#cb28-23"></a></span>
+<span id="cb28-24"><a href="#cb28-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb28-25"><a href="#cb28-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb28-26"><a href="#cb28-26"></a>adqs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adqs)</span>
+<span id="cb28-27"><a href="#cb28-27"></a></span>
+<span id="cb28-28"><a href="#cb28-28"></a>adqs_f <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb28-29"><a href="#cb28-29"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"FKSI-FWB"</span> <span class="sc">&amp;</span> <span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"SCREENING"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-30"><a href="#cb28-30"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb28-31"><a href="#cb28-31"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">ARMCD =</span> <span class="fu">factor</span>(ARMCD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb28-32"><a href="#cb28-32"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb28-33"><a href="#cb28-33"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb28-34"><a href="#cb28-34"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb28-35"><a href="#cb28-35"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb28-36"><a href="#cb28-36"></a>      <span class="fu">as.factor</span>()</span>
+<span id="cb28-37"><a href="#cb28-37"></a>  )</span>
+<span id="cb28-38"><a href="#cb28-38"></a>adsl_sub <span class="ot">&lt;-</span> adqs_f <span class="sc">%&gt;%</span></span>
+<span id="cb28-39"><a href="#cb28-39"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="sc">!</span><span class="fu">is.na</span>(CHG)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-40"><a href="#cb28-40"></a>  <span class="fu">distinct</span>(USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb28-41"><a href="#cb28-41"></a>  <span class="fu">left_join</span>(adsl, <span class="at">by =</span> <span class="st">"USUBJID"</span>)</span>
+<span id="cb28-42"><a href="#cb28-42"></a><span class="fu">var_labels</span>(adqs_f) <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adqs)</span>
+<span id="cb28-43"><a href="#cb28-43"></a><span class="in">```</span></span>
+<span id="cb28-44"><a href="#cb28-44"></a></span>
+<span id="cb28-45"><a href="#cb28-45"></a><span class="fu">## Least Squares Means</span></span>
+<span id="cb28-46"><a href="#cb28-46"></a></span>
+<span id="cb28-47"><a href="#cb28-47"></a><span class="fu">### Considering the treatment variable in the model</span></span>
+<span id="cb28-48"><a href="#cb28-48"></a></span>
+<span id="cb28-49"><a href="#cb28-49"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb28-50"><a href="#cb28-50"></a>mmrm_results <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb28-51"><a href="#cb28-51"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb28-52"><a href="#cb28-52"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb28-53"><a href="#cb28-53"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb28-54"><a href="#cb28-54"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb28-55"><a href="#cb28-55"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb28-56"><a href="#cb28-56"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb28-57"><a href="#cb28-57"></a>  ),</span>
+<span id="cb28-58"><a href="#cb28-58"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb28-59"><a href="#cb28-59"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span></span>
+<span id="cb28-60"><a href="#cb28-60"></a>)</span>
+<span id="cb28-61"><a href="#cb28-61"></a></span>
+<span id="cb28-62"><a href="#cb28-62"></a>df <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results)</span>
+<span id="cb28-63"><a href="#cb28-63"></a><span class="fu">attr</span>(df<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb28-64"><a href="#cb28-64"></a></span>
+<span id="cb28-65"><a href="#cb28-65"></a><span class="co"># Define the split function</span></span>
+<span id="cb28-66"><a href="#cb28-66"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb28-67"><a href="#cb28-67"></a></span>
+<span id="cb28-68"><a href="#cb28-68"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-69"><a href="#cb28-69"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb28-70"><a href="#cb28-70"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-71"><a href="#cb28-71"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-72"><a href="#cb28-72"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-73"><a href="#cb28-73"></a>  <span class="fu">build_table</span>(df, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb28-74"><a href="#cb28-74"></a></span>
+<span id="cb28-75"><a href="#cb28-75"></a>result</span>
+<span id="cb28-76"><a href="#cb28-76"></a><span class="in">```</span></span>
+<span id="cb28-77"><a href="#cb28-77"></a></span>
+<span id="cb28-78"><a href="#cb28-78"></a><span class="fu">### Not considering the treatment variable in the model</span></span>
+<span id="cb28-79"><a href="#cb28-79"></a></span>
+<span id="cb28-80"><a href="#cb28-80"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb28-81"><a href="#cb28-81"></a>mmrm_results_no_arm <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb28-82"><a href="#cb28-82"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb28-83"><a href="#cb28-83"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb28-84"><a href="#cb28-84"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BMRKR2"</span>, <span class="st">"STRATA1"</span>),</span>
+<span id="cb28-85"><a href="#cb28-85"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb28-86"><a href="#cb28-86"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb28-87"><a href="#cb28-87"></a>  ),</span>
+<span id="cb28-88"><a href="#cb28-88"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb28-89"><a href="#cb28-89"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb28-90"><a href="#cb28-90"></a>  <span class="at">parallel =</span> <span class="cn">TRUE</span></span>
+<span id="cb28-91"><a href="#cb28-91"></a>)</span>
+<span id="cb28-92"><a href="#cb28-92"></a></span>
+<span id="cb28-93"><a href="#cb28-93"></a>df_no_arm <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results_no_arm)</span>
+<span id="cb28-94"><a href="#cb28-94"></a><span class="fu">attr</span>(df_no_arm<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb28-95"><a href="#cb28-95"></a></span>
+<span id="cb28-96"><a href="#cb28-96"></a><span class="co"># Define the split function</span></span>
+<span id="cb28-97"><a href="#cb28-97"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb28-98"><a href="#cb28-98"></a></span>
+<span id="cb28-99"><a href="#cb28-99"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-100"><a href="#cb28-100"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-101"><a href="#cb28-101"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df_no_arm<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-102"><a href="#cb28-102"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">arms =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-103"><a href="#cb28-103"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-104"><a href="#cb28-104"></a>  <span class="fu">build_table</span>(df_no_arm, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb28-105"><a href="#cb28-105"></a></span>
+<span id="cb28-106"><a href="#cb28-106"></a>result</span>
+<span id="cb28-107"><a href="#cb28-107"></a><span class="in">```</span></span>
+<span id="cb28-108"><a href="#cb28-108"></a></span>
+<span id="cb28-109"><a href="#cb28-109"></a><span class="fu">### Adding baseline rows</span></span>
+<span id="cb28-110"><a href="#cb28-110"></a></span>
+<span id="cb28-111"><a href="#cb28-111"></a>It may be of interest to summarize some different statistics at the baseline visit or summarize a different variable in the data set not used in the MMRM.</span>
+<span id="cb28-112"><a href="#cb28-112"></a>For example, the model may use the variable <span class="in">`CHG`</span> but the baseline visit row may summarize the <span class="in">`AVAL`</span> variable, thus we would need to create two tables and then combine them to accomplish this.</span>
+<span id="cb28-113"><a href="#cb28-113"></a></span>
+<span id="cb28-116"><a href="#cb28-116"></a><span class="in">```{r}</span></span>
+<span id="cb28-117"><a href="#cb28-117"></a><span class="co"># First have the least-square means table.</span></span>
+<span id="cb28-118"><a href="#cb28-118"></a>a <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-119"><a href="#cb28-119"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb28-120"><a href="#cb28-120"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-121"><a href="#cb28-121"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-122"><a href="#cb28-122"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-123"><a href="#cb28-123"></a>  <span class="fu">build_table</span>(df, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb28-124"><a href="#cb28-124"></a></span>
+<span id="cb28-125"><a href="#cb28-125"></a><span class="co"># Second prepare the baseline values summary table.</span></span>
+<span id="cb28-126"><a href="#cb28-126"></a>baseline_dat <span class="ot">&lt;-</span> adqs <span class="sc">%&gt;%</span></span>
+<span id="cb28-127"><a href="#cb28-127"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"BASELINE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-128"><a href="#cb28-128"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb28-129"><a href="#cb28-129"></a></span>
+<span id="cb28-130"><a href="#cb28-130"></a>b <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-131"><a href="#cb28-131"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-132"><a href="#cb28-132"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-133"><a href="#cb28-133"></a>  <span class="fu">analyze_vars</span>(<span class="st">"AVAL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-134"><a href="#cb28-134"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-135"><a href="#cb28-135"></a>  <span class="fu">build_table</span>(baseline_dat, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb28-136"><a href="#cb28-136"></a></span>
+<span id="cb28-137"><a href="#cb28-137"></a><span class="co"># Now we can combine them as follows.</span></span>
+<span id="cb28-138"><a href="#cb28-138"></a><span class="fu">col_info</span>(b) <span class="ot">&lt;-</span> EmptyColInfo</span>
+<span id="cb28-139"><a href="#cb28-139"></a><span class="fu">rbind</span>(b, a)</span>
+<span id="cb28-140"><a href="#cb28-140"></a><span class="in">```</span></span>
+<span id="cb28-141"><a href="#cb28-141"></a></span>
+<span id="cb28-142"><a href="#cb28-142"></a><span class="fu">### Considering visit averages</span></span>
+<span id="cb28-143"><a href="#cb28-143"></a></span>
+<span id="cb28-144"><a href="#cb28-144"></a>It may also be of interest to summarize several different statistics for an averaged combination of various visits in the MMRM.</span>
+<span id="cb28-145"><a href="#cb28-145"></a>For example, you may want to see the statistics for the average of the first 2 visits, or the average statistics of all visits combined.</span>
+<span id="cb28-146"><a href="#cb28-146"></a>This can be accomplished by specifying the <span class="in">`averages_emmeans`</span> argument when fitting the MMRM model.</span>
+<span id="cb28-147"><a href="#cb28-147"></a></span>
+<span id="cb28-148"><a href="#cb28-148"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb28-149"><a href="#cb28-149"></a>mmrm_results_avg_visits <span class="ot">&lt;-</span> <span class="fu">fit_mmrm</span>(</span>
+<span id="cb28-150"><a href="#cb28-150"></a>  <span class="at">vars =</span> <span class="fu">list</span>(</span>
+<span id="cb28-151"><a href="#cb28-151"></a>    <span class="at">response =</span> <span class="st">"CHG"</span>,</span>
+<span id="cb28-152"><a href="#cb28-152"></a>    <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"BMRKR2"</span>),</span>
+<span id="cb28-153"><a href="#cb28-153"></a>    <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb28-154"><a href="#cb28-154"></a>    <span class="at">arm =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb28-155"><a href="#cb28-155"></a>    <span class="at">visit =</span> <span class="st">"AVISIT"</span></span>
+<span id="cb28-156"><a href="#cb28-156"></a>  ),</span>
+<span id="cb28-157"><a href="#cb28-157"></a>  <span class="at">data =</span> adqs_f,</span>
+<span id="cb28-158"><a href="#cb28-158"></a>  <span class="at">weights_emmeans =</span> <span class="st">"equal"</span>,</span>
+<span id="cb28-159"><a href="#cb28-159"></a>  <span class="at">averages_emmeans =</span> <span class="fu">list</span>(</span>
+<span id="cb28-160"><a href="#cb28-160"></a>    <span class="st">"WEEKS 1-2"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>),</span>
+<span id="cb28-161"><a href="#cb28-161"></a>    <span class="st">"WEEKS 3-5"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>, <span class="st">"WEEK 5 DAY 36"</span>),</span>
+<span id="cb28-162"><a href="#cb28-162"></a>    <span class="st">"ALL VISITS"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>, <span class="st">"WEEK 4 DAY 29"</span>, <span class="st">"WEEK 5 DAY 36"</span>)</span>
+<span id="cb28-163"><a href="#cb28-163"></a>  )</span>
+<span id="cb28-164"><a href="#cb28-164"></a>)</span>
+<span id="cb28-165"><a href="#cb28-165"></a></span>
+<span id="cb28-166"><a href="#cb28-166"></a>df_avgs <span class="ot">&lt;-</span> <span class="fu">tidy</span>(mmrm_results_avg_visits)</span>
+<span id="cb28-167"><a href="#cb28-167"></a><span class="fu">attr</span>(df_avgs<span class="sc">$</span>AVISIT, <span class="st">"label"</span>) <span class="ot">&lt;-</span> <span class="st">"Visit"</span></span>
+<span id="cb28-168"><a href="#cb28-168"></a></span>
+<span id="cb28-169"><a href="#cb28-169"></a><span class="co"># Define the split function</span></span>
+<span id="cb28-170"><a href="#cb28-170"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb28-171"><a href="#cb28-171"></a></span>
+<span id="cb28-172"><a href="#cb28-172"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-173"><a href="#cb28-173"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> mmrm_results_avg_visits<span class="sc">$</span>ref_level) <span class="sc">%&gt;%</span></span>
+<span id="cb28-174"><a href="#cb28-174"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df_avgs<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-175"><a href="#cb28-175"></a>  <span class="fu">summarize_lsmeans</span>(<span class="at">show_relative =</span> <span class="st">"increase"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-176"><a href="#cb28-176"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Statistics"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-177"><a href="#cb28-177"></a>  <span class="fu">build_table</span>(df_avgs, <span class="at">alt_counts_df =</span> adsl_sub)</span>
+<span id="cb28-178"><a href="#cb28-178"></a></span>
+<span id="cb28-179"><a href="#cb28-179"></a>result</span>
+<span id="cb28-180"><a href="#cb28-180"></a><span class="in">```</span></span>
+<span id="cb28-181"><a href="#cb28-181"></a></span>
+<span id="cb28-182"><a href="#cb28-182"></a><span class="fu">## Fixed Effects</span></span>
+<span id="cb28-183"><a href="#cb28-183"></a></span>
+<span id="cb28-184"><a href="#cb28-184"></a><span class="fu">#### Considering the treatment variable in the model</span></span>
+<span id="cb28-185"><a href="#cb28-185"></a></span>
+<span id="cb28-188"><a href="#cb28-188"></a><span class="in">```{r}</span></span>
+<span id="cb28-189"><a href="#cb28-189"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"fixed"</span>)</span>
+<span id="cb28-190"><a href="#cb28-190"></a><span class="in">```</span></span>
+<span id="cb28-191"><a href="#cb28-191"></a></span>
+<span id="cb28-192"><a href="#cb28-192"></a><span class="fu">#### Not considering the treatment variable in the model</span></span>
+<span id="cb28-193"><a href="#cb28-193"></a></span>
+<span id="cb28-196"><a href="#cb28-196"></a><span class="in">```{r}</span></span>
+<span id="cb28-197"><a href="#cb28-197"></a><span class="fu">as.rtable</span>(mmrm_results_no_arm, <span class="at">type =</span> <span class="st">"fixed"</span>)</span>
+<span id="cb28-198"><a href="#cb28-198"></a><span class="in">```</span></span>
+<span id="cb28-199"><a href="#cb28-199"></a></span>
+<span id="cb28-200"><a href="#cb28-200"></a><span class="fu">## Covariance Matrix</span></span>
+<span id="cb28-201"><a href="#cb28-201"></a></span>
+<span id="cb28-204"><a href="#cb28-204"></a><span class="in">```{r}</span></span>
+<span id="cb28-205"><a href="#cb28-205"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"cov"</span>)</span>
+<span id="cb28-206"><a href="#cb28-206"></a><span class="in">```</span></span>
+<span id="cb28-207"><a href="#cb28-207"></a></span>
+<span id="cb28-208"><a href="#cb28-208"></a><span class="fu">## Model Diagnostics</span></span>
+<span id="cb28-209"><a href="#cb28-209"></a></span>
+<span id="cb28-210"><a href="#cb28-210"></a>Model diagnostics are currently available to evaluate choice of covariates for the fixed and random effects.</span>
+<span id="cb28-211"><a href="#cb28-211"></a>Statistics to evaluate choice of covariance structure are being investigated and will be included in a future release.</span>
+<span id="cb28-212"><a href="#cb28-212"></a></span>
+<span id="cb28-215"><a href="#cb28-215"></a><span class="in">```{r}</span></span>
+<span id="cb28-216"><a href="#cb28-216"></a><span class="fu">as.rtable</span>(mmrm_results, <span class="at">type =</span> <span class="st">"diagnostic"</span>)</span>
+<span id="cb28-217"><a href="#cb28-217"></a><span class="in">```</span></span>
+<span id="cb28-218"><a href="#cb28-218"></a></span>
+<span id="cb28-219"><a href="#cb28-219"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb28-220"><a href="#cb28-220"></a></span>
+<span id="cb28-221"><a href="#cb28-221"></a><span class="fu">## `teal` App</span></span>
+<span id="cb28-222"><a href="#cb28-222"></a></span>
+<span id="cb28-223"><a href="#cb28-223"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb28-224"><a href="#cb28-224"></a><span class="co">#| screenshot.opts = list(delay = 24)</span></span>
+<span id="cb28-225"><a href="#cb28-225"></a></span>
+<span id="cb28-226"><a href="#cb28-226"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb28-227"><a href="#cb28-227"></a><span class="fu">library</span>(scda)</span>
+<span id="cb28-228"><a href="#cb28-228"></a></span>
+<span id="cb28-229"><a href="#cb28-229"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb28-230"><a href="#cb28-230"></a>adqs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adqs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-231"><a href="#cb28-231"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb28-232"><a href="#cb28-232"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEK 1 DAY 8"</span>, <span class="st">"WEEK 2 DAY 15"</span>, <span class="st">"WEEK 3 DAY 22"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb28-233"><a href="#cb28-233"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb28-234"><a href="#cb28-234"></a>    <span class="at">AVISIT =</span> <span class="fu">as.factor</span>(AVISIT),</span>
+<span id="cb28-235"><a href="#cb28-235"></a>    <span class="at">AVISITN =</span> <span class="fu">rank</span>(AVISITN) <span class="sc">%&gt;%</span></span>
+<span id="cb28-236"><a href="#cb28-236"></a>      <span class="fu">as.factor</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb28-237"><a href="#cb28-237"></a>      <span class="fu">as.numeric</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb28-238"><a href="#cb28-238"></a>      <span class="fu">as.factor</span>() <span class="co"># making consecutive numeric factor</span></span>
+<span id="cb28-239"><a href="#cb28-239"></a>  )</span>
+<span id="cb28-240"><a href="#cb28-240"></a></span>
+<span id="cb28-241"><a href="#cb28-241"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb28-242"><a href="#cb28-242"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb28-243"><a href="#cb28-243"></a>    <span class="at">ref =</span> <span class="st">"ARM A"</span>,</span>
+<span id="cb28-244"><a href="#cb28-244"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM B"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb28-245"><a href="#cb28-245"></a>  )</span>
+<span id="cb28-246"><a href="#cb28-246"></a>)</span>
+<span id="cb28-247"><a href="#cb28-247"></a></span>
+<span id="cb28-248"><a href="#cb28-248"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb28-249"><a href="#cb28-249"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb28-250"><a href="#cb28-250"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb28-251"><a href="#cb28-251"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADQS"</span>, adqs,</span>
+<span id="cb28-252"><a href="#cb28-252"></a>      <span class="at">code =</span> <span class="st">'ADQS &lt;- synthetic_cdisc_dataset("latest", "adqs") %&gt;%</span></span>
+<span id="cb28-253"><a href="#cb28-253"></a><span class="st">              dplyr::filter(ABLFL != "Y" &amp; ABLFL2 != "Y") %&gt;%</span></span>
+<span id="cb28-254"><a href="#cb28-254"></a><span class="st">              dplyr::filter(AVISIT %in% c("WEEK 1 DAY 8", "WEEK 2 DAY 15", "WEEK 3 DAY 22")) %&gt;%</span></span>
+<span id="cb28-255"><a href="#cb28-255"></a><span class="st">              dplyr::mutate(</span></span>
+<span id="cb28-256"><a href="#cb28-256"></a><span class="st">                AVISIT = as.factor(AVISIT),</span></span>
+<span id="cb28-257"><a href="#cb28-257"></a><span class="st">                AVISITN = rank(AVISITN) %&gt;%</span></span>
+<span id="cb28-258"><a href="#cb28-258"></a><span class="st">                  as.factor() %&gt;%</span></span>
+<span id="cb28-259"><a href="#cb28-259"></a><span class="st">                  as.numeric() %&gt;%</span></span>
+<span id="cb28-260"><a href="#cb28-260"></a><span class="st">                  as.factor() # making consecutive numeric factor</span></span>
+<span id="cb28-261"><a href="#cb28-261"></a><span class="st">              )'</span></span>
+<span id="cb28-262"><a href="#cb28-262"></a>    ),</span>
+<span id="cb28-263"><a href="#cb28-263"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb28-264"><a href="#cb28-264"></a>  ),</span>
+<span id="cb28-265"><a href="#cb28-265"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb28-266"><a href="#cb28-266"></a>    <span class="fu">tm_a_mmrm</span>(</span>
+<span id="cb28-267"><a href="#cb28-267"></a>      <span class="at">label =</span> <span class="st">"MMRM"</span>,</span>
+<span id="cb28-268"><a href="#cb28-268"></a>      <span class="at">dataname =</span> <span class="st">"ADQS"</span>,</span>
+<span id="cb28-269"><a href="#cb28-269"></a>      <span class="at">aval_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>), <span class="st">"CHG"</span>),</span>
+<span id="cb28-270"><a href="#cb28-270"></a>      <span class="at">id_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"SUBJID"</span>), <span class="st">"USUBJID"</span>),</span>
+<span id="cb28-271"><a href="#cb28-271"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARMCD"</span>),</span>
+<span id="cb28-272"><a href="#cb28-272"></a>      <span class="at">visit_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"AVISITN"</span>), <span class="st">"AVISIT"</span>),</span>
+<span id="cb28-273"><a href="#cb28-273"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb28-274"><a href="#cb28-274"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb28-275"><a href="#cb28-275"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adqs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb28-276"><a href="#cb28-276"></a>        <span class="at">selected =</span> <span class="st">"FKSI-FWB"</span></span>
+<span id="cb28-277"><a href="#cb28-277"></a>      ),</span>
+<span id="cb28-278"><a href="#cb28-278"></a>      <span class="at">cov_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"BASE"</span>, <span class="st">"AGE"</span>, <span class="st">"SEX"</span>, <span class="st">"BASE:AVISIT"</span>), <span class="cn">NULL</span>),</span>
+<span id="cb28-279"><a href="#cb28-279"></a>      <span class="at">conf_level =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="fl">0.95</span>, <span class="fl">0.9</span>, <span class="fl">0.8</span>), <span class="fl">0.95</span>)</span>
+<span id="cb28-280"><a href="#cb28-280"></a>    )</span>
+<span id="cb28-281"><a href="#cb28-281"></a>  )</span>
+<span id="cb28-282"><a href="#cb28-282"></a>)</span>
+<span id="cb28-283"><a href="#cb28-283"></a></span>
+<span id="cb28-284"><a href="#cb28-284"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb28-285"><a href="#cb28-285"></a><span class="in">```</span></span>
+<span id="cb28-286"><a href="#cb28-286"></a></span>
+<span id="cb28-287"><a href="#cb28-287"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb28-288"><a href="#cb28-288"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/efficacy/onct05.html
@@ -0,0 +1,2396 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - ONCT05</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
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+div.sourceCode { margin: 1em 0; }
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+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
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+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
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+  { content: counter(source-line);
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
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+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ONCT05</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Objective Response Rate by Subgroup</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Specifying <br> Class Variables</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Selecting Columns <br> and Changing the Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table Setting Values <br> Indicating Response</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="onct05_cache/html/setup_bebb73e126d42b7166f453bf2190439d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, SEX, RACE, STRATA1, STRATA2)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC)</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a>anl <span class="ot">&lt;-</span> <span class="fu">inner_join</span>(adsl, adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb1-20"><a href="#cb1-20"></a>anl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(anl)</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="co"># Reorder levels of factor to make the placebo group the reference arm.</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(<span class="at">rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>))</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a><span class="fu">var_labels</span>(anl) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">rsp =</span> <span class="st">"Is Response"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="onct05_cache/html/variant1_f399ca403274640ecae77cfd74680534">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">rsp =</span> <span class="st">"rsp"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  ),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="at">data =</span> anl</span>
+<span id="cb2-8"><a href="#cb2-8"></a>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a></span>
+<span id="cb2-10"><a href="#cb2-10"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                         B: Placebo                         A: Drug X                                       
+                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.04, 2.95)
+Sex                                                                                                                              
+  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.21, 4.76)
+  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.47, 2.48)
+Stratification Factor 2                                                                                                          
+  S1                        140     67        38          56.7%       73        56          76.7%          2.51      (1.22, 5.20)
+  S2                        128     67        46          68.7%       61        44          72.1%          1.18      (0.55, 2.53)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Here, the levels of subgroup variables <code>SEX</code> and <code>STRATA1</code> are reordered. <code>STRATA1</code> is reordered by frequency.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="onct05_cache/html/variant2_c1bf945a1deb5108123171c1276e78ab">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>anl_reorder <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-3"><a href="#cb4-3"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  )</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">rsp =</span> <span class="st">"rsp"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="at">data =</span> anl_reorder</span>
+<span id="cb4-10"><a href="#cb4-10"></a>)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb4-14"><a href="#cb4-14"></a></span>
+<span id="cb4-15"><a href="#cb4-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                         B: Placebo                         A: Drug X                                       
+                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.04, 2.95)
+Sex                                                                                                                              
+  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.47, 2.48)
+  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.21, 4.76)
+Stratification Factor 1                                                                                                          
+  C                         94      45        33          73.3%       49        37          75.5%          1.12      (0.44, 2.83)
+  B                         92      45        26          57.8%       47        32          68.1%          1.56      (0.66, 3.66)
+  A                         82      44        25          56.8%       38        31          81.6%          3.37      (1.22, 9.28)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="onct05_cache/html/variant3_2de45c702c2e7b30713dc8a05972e3e9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb6-3"><a href="#cb6-3"></a>    <span class="at">rsp =</span> <span class="st">"rsp"</span>,</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>  ),</span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="at">data =</span> anl,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="at">conf_level =</span> <span class="fl">0.9</span>,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="at">method =</span> <span class="st">"chisq"</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>)</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>))</span>
+<span id="cb6-14"><a href="#cb6-14"></a></span>
+<span id="cb6-15"><a href="#cb6-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                         B: Placebo                         A: Drug X                                                                    
+                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      90% CI      p-value (Chi-Squared Test)
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                268     134       84          62.7%       134      100          74.6%          1.75      (1.13, 2.72)             0.0351          
+Sex                                                                                                                                                           
+  F                         161     82        48          58.5%       79        61          77.2%          2.40      (1.35, 4.27)             0.0113          
+  M                         107     52        36          69.2%       55        39          70.9%          1.08      (0.54, 2.17)             0.8497          
+Stratification Factor 2                                                                                                                                       
+  S1                        140     67        38          56.7%       73        56          76.7%          2.51      (1.37, 4.63)             0.0119          
+  S2                        128     67        46          68.7%       61        44          72.1%          1.18      (0.62, 2.24)             0.6674          </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Create a new variable <code>new_rsp</code> in <code>anl</code> data that uses new criteria for responder.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="onct05_cache/html/variant4_331c1e1782b907c4ef1bb865ad8cc84c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>anl_new <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">mutate</span>(<span class="at">new_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">rsp =</span> <span class="st">"new_rsp"</span>,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb8-9"><a href="#cb8-9"></a>  ),</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="at">data =</span> anl_new</span>
+<span id="cb8-11"><a href="#cb8-11"></a>)</span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Baseline Risk Factors                         B: Placebo                         A: Drug X                                       
+                          Total n    n    Responders   Response (%)    n    Responders   Response (%)   Odds Ratio      95% CI   
+—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+All Patients                268     134       47          35.1%       134       60          44.8%          1.50      (0.92, 2.45)
+Sex                                                                                                                              
+  F                         161     82        25          30.5%       79        39          49.4%          2.22      (1.17, 4.24)
+  M                         107     52        22          42.3%       55        21          38.2%          0.84      (0.39, 1.83)
+Stratification Factor 2                                                                                                          
+  S1                        140     67        21          31.3%       73        31          42.5%          1.62      (0.81, 3.24)
+  S2                        128     67        26          38.8%       61        29          47.5%          1.43      (0.71, 2.89)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:24}" data-hash="onct05_cache/html/teal_348fce27023093581d402ebd776aee3b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># Use table, embedded in response forest plot module.</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb10-5"><a href="#cb10-5"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-6"><a href="#cb10-6"></a></span>
+<span id="cb10-7"><a href="#cb10-7"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-8"><a href="#cb10-8"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-11"><a href="#cb10-11"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-12"><a href="#cb10-12"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb10-13"><a href="#cb10-13"></a></span>
+<span id="cb10-14"><a href="#cb10-14"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb10-15"><a href="#cb10-15"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb10-16"><a href="#cb10-16"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb10-18"><a href="#cb10-18"></a>  ),</span>
+<span id="cb10-19"><a href="#cb10-19"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb10-20"><a href="#cb10-20"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a>  )</span>
+<span id="cb10-23"><a href="#cb10-23"></a>)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-26"><a href="#cb10-26"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, adrs, <span class="at">code =</span> <span class="st">'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adrs"))'</span>),</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  ),</span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="fu">tm_g_forest_rsp</span>(</span>
+<span id="cb10-33"><a href="#cb10-33"></a>      <span class="at">label =</span> <span class="st">"Forest Response"</span>,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb10-35"><a href="#cb10-35"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-36"><a href="#cb10-36"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>        <span class="st">"ARMCD"</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>      ),</span>
+<span id="cb10-39"><a href="#cb10-39"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>        <span class="fu">value_choices</span>(adrs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-42"><a href="#cb10-42"></a>        <span class="st">"BESRSPI"</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>      ),</span>
+<span id="cb10-44"><a href="#cb10-44"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-45"><a href="#cb10-45"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">names</span>(adsl)),</span>
+<span id="cb10-46"><a href="#cb10-46"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>)</span>
+<span id="cb10-47"><a href="#cb10-47"></a>      ),</span>
+<span id="cb10-48"><a href="#cb10-48"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-49"><a href="#cb10-49"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)),</span>
+<span id="cb10-50"><a href="#cb10-50"></a>        <span class="st">"STRATA2"</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>      ),</span>
+<span id="cb10-52"><a href="#cb10-52"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(600L, 200L, 2000L)</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    )</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  )</span>
+<span id="cb10-55"><a href="#cb10-55"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:58:54.4195 pid:7461 token:[] teal.modules.clinical Initializing tm_g_forest_rsp</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="onct05_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="onct05_cache/html/sessioninfo_d6652776ddf9b3945fd7bd9961d7970b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] forcats_1.0.0                teal.modules.clinical_0.8.16
+ [3] teal_0.14.0                  teal.transform_0.4.0        
+ [5] teal.slice_0.4.0             teal.data_0.3.0             
+ [7] shiny_1.7.5                  scda_0.1.6                  
+ [9] dplyr_1.1.3                  tern_0.9.0                  
+[11] rtables_0.6.3                magrittr_2.0.3              
+[13] formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="onct05_cache/html/snapshot_fcfad4e69b29b93068359af97f839ed9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/onct05.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
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+          if (clickedEl !== selectedAnnoteEl) {
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+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> ONCT05</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Objective Response Rate by Subgroup</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-21"><a href="#cb16-21"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-25"><a href="#cb16-25"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb16-26"><a href="#cb16-26"></a></span>
+<span id="cb16-27"><a href="#cb16-27"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, SEX, RACE, STRATA1, STRATA2)</span>
+<span id="cb16-29"><a href="#cb16-29"></a></span>
+<span id="cb16-30"><a href="#cb16-30"></a>adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb16-31"><a href="#cb16-31"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-32"><a href="#cb16-32"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC)</span>
+<span id="cb16-33"><a href="#cb16-33"></a></span>
+<span id="cb16-34"><a href="#cb16-34"></a>anl <span class="ot">&lt;-</span> <span class="fu">inner_join</span>(adsl, adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb16-35"><a href="#cb16-35"></a>anl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(anl)</span>
+<span id="cb16-36"><a href="#cb16-36"></a></span>
+<span id="cb16-37"><a href="#cb16-37"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb16-38"><a href="#cb16-38"></a>  <span class="fu">filter</span>(ARM <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"B: Placebo"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-39"><a href="#cb16-39"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-40"><a href="#cb16-40"></a>    <span class="co"># Reorder levels of factor to make the placebo group the reference arm.</span></span>
+<span id="cb16-41"><a href="#cb16-41"></a>    <span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-42"><a href="#cb16-42"></a>      <span class="fu">droplevels</span>()</span>
+<span id="cb16-43"><a href="#cb16-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-44"><a href="#cb16-44"></a>  <span class="fu">droplevels</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a>  <span class="fu">mutate</span>(<span class="at">rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>))</span>
+<span id="cb16-46"><a href="#cb16-46"></a></span>
+<span id="cb16-47"><a href="#cb16-47"></a><span class="fu">var_labels</span>(anl) <span class="ot">&lt;-</span> <span class="fu">c</span>(anl_labels, <span class="at">rsp =</span> <span class="st">"Is Response"</span>)</span>
+<span id="cb16-48"><a href="#cb16-48"></a><span class="in">```</span></span>
+<span id="cb16-49"><a href="#cb16-49"></a></span>
+<span id="cb16-50"><a href="#cb16-50"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-51"><a href="#cb16-51"></a></span>
+<span id="cb16-52"><a href="#cb16-52"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-53"><a href="#cb16-53"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb16-54"><a href="#cb16-54"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-55"><a href="#cb16-55"></a>    <span class="at">rsp =</span> <span class="st">"rsp"</span>,</span>
+<span id="cb16-56"><a href="#cb16-56"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-57"><a href="#cb16-57"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb16-58"><a href="#cb16-58"></a>  ),</span>
+<span id="cb16-59"><a href="#cb16-59"></a>  <span class="at">data =</span> anl</span>
+<span id="cb16-60"><a href="#cb16-60"></a>)</span>
+<span id="cb16-61"><a href="#cb16-61"></a></span>
+<span id="cb16-62"><a href="#cb16-62"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-63"><a href="#cb16-63"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb16-64"><a href="#cb16-64"></a></span>
+<span id="cb16-65"><a href="#cb16-65"></a>result</span>
+<span id="cb16-66"><a href="#cb16-66"></a><span class="in">```</span></span>
+<span id="cb16-67"><a href="#cb16-67"></a></span>
+<span id="cb16-68"><a href="#cb16-68"></a><span class="fu">## Table Specifying &lt;br/&gt; Class Variables</span></span>
+<span id="cb16-69"><a href="#cb16-69"></a></span>
+<span id="cb16-70"><a href="#cb16-70"></a>Here, the levels of subgroup variables <span class="in">`SEX`</span> and <span class="in">`STRATA1`</span> are reordered.</span>
+<span id="cb16-71"><a href="#cb16-71"></a><span class="in">`STRATA1`</span> is reordered by frequency.</span>
+<span id="cb16-72"><a href="#cb16-72"></a></span>
+<span id="cb16-73"><a href="#cb16-73"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-74"><a href="#cb16-74"></a>anl_reorder <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-76"><a href="#cb16-76"></a>    <span class="at">SEX =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(SEX, <span class="st">"M"</span>, <span class="st">"F"</span>),</span>
+<span id="cb16-77"><a href="#cb16-77"></a>    <span class="at">STRATA1 =</span> forcats<span class="sc">::</span><span class="fu">fct_infreq</span>(STRATA1)</span>
+<span id="cb16-78"><a href="#cb16-78"></a>  )</span>
+<span id="cb16-79"><a href="#cb16-79"></a></span>
+<span id="cb16-80"><a href="#cb16-80"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb16-81"><a href="#cb16-81"></a>  <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">rsp =</span> <span class="st">"rsp"</span>, <span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA1"</span>)),</span>
+<span id="cb16-82"><a href="#cb16-82"></a>  <span class="at">data =</span> anl_reorder</span>
+<span id="cb16-83"><a href="#cb16-83"></a>)</span>
+<span id="cb16-84"><a href="#cb16-84"></a></span>
+<span id="cb16-85"><a href="#cb16-85"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-86"><a href="#cb16-86"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb16-87"><a href="#cb16-87"></a></span>
+<span id="cb16-88"><a href="#cb16-88"></a>result</span>
+<span id="cb16-89"><a href="#cb16-89"></a><span class="in">```</span></span>
+<span id="cb16-90"><a href="#cb16-90"></a></span>
+<span id="cb16-91"><a href="#cb16-91"></a><span class="fu">## Table Selecting Columns &lt;br/&gt; and Changing the Alpha Level</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a></span>
+<span id="cb16-93"><a href="#cb16-93"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-94"><a href="#cb16-94"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb16-95"><a href="#cb16-95"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-96"><a href="#cb16-96"></a>    <span class="at">rsp =</span> <span class="st">"rsp"</span>,</span>
+<span id="cb16-97"><a href="#cb16-97"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-98"><a href="#cb16-98"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb16-99"><a href="#cb16-99"></a>  ),</span>
+<span id="cb16-100"><a href="#cb16-100"></a>  <span class="at">data =</span> anl,</span>
+<span id="cb16-101"><a href="#cb16-101"></a>  <span class="at">conf_level =</span> <span class="fl">0.9</span>,</span>
+<span id="cb16-102"><a href="#cb16-102"></a>  <span class="at">method =</span> <span class="st">"chisq"</span></span>
+<span id="cb16-103"><a href="#cb16-103"></a>)</span>
+<span id="cb16-104"><a href="#cb16-104"></a></span>
+<span id="cb16-105"><a href="#cb16-105"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-106"><a href="#cb16-106"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>, <span class="st">"pval"</span>))</span>
+<span id="cb16-107"><a href="#cb16-107"></a></span>
+<span id="cb16-108"><a href="#cb16-108"></a>result</span>
+<span id="cb16-109"><a href="#cb16-109"></a><span class="in">```</span></span>
+<span id="cb16-110"><a href="#cb16-110"></a></span>
+<span id="cb16-111"><a href="#cb16-111"></a><span class="fu">## Table Setting Values &lt;br/&gt; Indicating Response</span></span>
+<span id="cb16-112"><a href="#cb16-112"></a></span>
+<span id="cb16-113"><a href="#cb16-113"></a>Create a new variable <span class="in">`new_rsp`</span> in <span class="in">`anl`</span> data that uses new criteria for responder.</span>
+<span id="cb16-114"><a href="#cb16-114"></a></span>
+<span id="cb16-115"><a href="#cb16-115"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-116"><a href="#cb16-116"></a>anl_new <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb16-117"><a href="#cb16-117"></a>  <span class="fu">mutate</span>(<span class="at">new_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>)</span>
+<span id="cb16-118"><a href="#cb16-118"></a></span>
+<span id="cb16-119"><a href="#cb16-119"></a>df <span class="ot">&lt;-</span> <span class="fu">extract_rsp_subgroups</span>(</span>
+<span id="cb16-120"><a href="#cb16-120"></a>  <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb16-121"><a href="#cb16-121"></a>    <span class="at">rsp =</span> <span class="st">"new_rsp"</span>,</span>
+<span id="cb16-122"><a href="#cb16-122"></a>    <span class="at">arm =</span> <span class="st">"ARM"</span>,</span>
+<span id="cb16-123"><a href="#cb16-123"></a>    <span class="at">subgroups =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"STRATA2"</span>)</span>
+<span id="cb16-124"><a href="#cb16-124"></a>  ),</span>
+<span id="cb16-125"><a href="#cb16-125"></a>  <span class="at">data =</span> anl_new</span>
+<span id="cb16-126"><a href="#cb16-126"></a>)</span>
+<span id="cb16-127"><a href="#cb16-127"></a></span>
+<span id="cb16-128"><a href="#cb16-128"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-129"><a href="#cb16-129"></a>  <span class="fu">tabulate_rsp_subgroups</span>(df, <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"n_tot"</span>, <span class="st">"n"</span>, <span class="st">"n_rsp"</span>, <span class="st">"prop"</span>, <span class="st">"or"</span>, <span class="st">"ci"</span>))</span>
+<span id="cb16-130"><a href="#cb16-130"></a></span>
+<span id="cb16-131"><a href="#cb16-131"></a>result</span>
+<span id="cb16-132"><a href="#cb16-132"></a><span class="in">```</span></span>
+<span id="cb16-133"><a href="#cb16-133"></a></span>
+<span id="cb16-134"><a href="#cb16-134"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-135"><a href="#cb16-135"></a></span>
+<span id="cb16-136"><a href="#cb16-136"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-137"><a href="#cb16-137"></a></span>
+<span id="cb16-138"><a href="#cb16-138"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-139"><a href="#cb16-139"></a><span class="co">#| screenshot.opts = list(delay = 24)</span></span>
+<span id="cb16-140"><a href="#cb16-140"></a></span>
+<span id="cb16-141"><a href="#cb16-141"></a><span class="co"># Use table, embedded in response forest plot module.</span></span>
+<span id="cb16-142"><a href="#cb16-142"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-143"><a href="#cb16-143"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-144"><a href="#cb16-144"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb16-145"><a href="#cb16-145"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-146"><a href="#cb16-146"></a></span>
+<span id="cb16-147"><a href="#cb16-147"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-148"><a href="#cb16-148"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb16-149"><a href="#cb16-149"></a></span>
+<span id="cb16-150"><a href="#cb16-150"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-152"><a href="#cb16-152"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb16-153"><a href="#cb16-153"></a></span>
+<span id="cb16-154"><a href="#cb16-154"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb16-155"><a href="#cb16-155"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb16-156"><a href="#cb16-156"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb16-157"><a href="#cb16-157"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb16-158"><a href="#cb16-158"></a>  ),</span>
+<span id="cb16-159"><a href="#cb16-159"></a>  <span class="at">ARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb16-160"><a href="#cb16-160"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb16-161"><a href="#cb16-161"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb16-162"><a href="#cb16-162"></a>  )</span>
+<span id="cb16-163"><a href="#cb16-163"></a>)</span>
+<span id="cb16-164"><a href="#cb16-164"></a></span>
+<span id="cb16-165"><a href="#cb16-165"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-166"><a href="#cb16-166"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-167"><a href="#cb16-167"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb16-168"><a href="#cb16-168"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADRS"</span>, adrs, <span class="at">code =</span> <span class="st">'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adrs"))'</span>),</span>
+<span id="cb16-169"><a href="#cb16-169"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-170"><a href="#cb16-170"></a>  ),</span>
+<span id="cb16-171"><a href="#cb16-171"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-172"><a href="#cb16-172"></a>    <span class="fu">tm_g_forest_rsp</span>(</span>
+<span id="cb16-173"><a href="#cb16-173"></a>      <span class="at">label =</span> <span class="st">"Forest Response"</span>,</span>
+<span id="cb16-174"><a href="#cb16-174"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb16-175"><a href="#cb16-175"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-176"><a href="#cb16-176"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb16-177"><a href="#cb16-177"></a>        <span class="st">"ARMCD"</span></span>
+<span id="cb16-178"><a href="#cb16-178"></a>      ),</span>
+<span id="cb16-179"><a href="#cb16-179"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb16-180"><a href="#cb16-180"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-181"><a href="#cb16-181"></a>        <span class="fu">value_choices</span>(adrs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb16-182"><a href="#cb16-182"></a>        <span class="st">"BESRSPI"</span></span>
+<span id="cb16-183"><a href="#cb16-183"></a>      ),</span>
+<span id="cb16-184"><a href="#cb16-184"></a>      <span class="at">subgroup_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-185"><a href="#cb16-185"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">names</span>(adsl)),</span>
+<span id="cb16-186"><a href="#cb16-186"></a>        <span class="fu">c</span>(<span class="st">"SEX"</span>)</span>
+<span id="cb16-187"><a href="#cb16-187"></a>      ),</span>
+<span id="cb16-188"><a href="#cb16-188"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-189"><a href="#cb16-189"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"STRATA1"</span>, <span class="st">"STRATA2"</span>)),</span>
+<span id="cb16-190"><a href="#cb16-190"></a>        <span class="st">"STRATA2"</span></span>
+<span id="cb16-191"><a href="#cb16-191"></a>      ),</span>
+<span id="cb16-192"><a href="#cb16-192"></a>      <span class="at">plot_height =</span> <span class="fu">c</span>(600L, 200L, 2000L)</span>
+<span id="cb16-193"><a href="#cb16-193"></a>    )</span>
+<span id="cb16-194"><a href="#cb16-194"></a>  )</span>
+<span id="cb16-195"><a href="#cb16-195"></a>)</span>
+<span id="cb16-196"><a href="#cb16-196"></a></span>
+<span id="cb16-197"><a href="#cb16-197"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-198"><a href="#cb16-198"></a><span class="in">```</span></span>
+<span id="cb16-199"><a href="#cb16-199"></a></span>
+<span id="cb16-200"><a href="#cb16-200"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-201"><a href="#cb16-201"></a></span>
+<span id="cb16-202"><a href="#cb16-202"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RATET01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Event Rate Summary for Recurrent Events</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<p>This example will focus on data from a single visit “WEEK 1 DAY 8” and a single endpoint “FKSI-FWB”. Only evaluable populations will be analyzed.</p>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Customized Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ratet01_cache/html/setup_d556ec8b524bbb4a99f86b7d02dd170d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>anl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNE"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure number of exacerbation is a factor and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>anl<span class="sc">$</span>AVAL_f <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>AVAL)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="ratet01_cache/html/variant1_b46d04340f60a2425eb31faceff1f9bb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"AVAL_f"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">var_labels =</span> <span class="st">"Number of exacerbations per patient"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> <span class="st">"xx (xx.xx%)"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.label =</span> <span class="fu">c</span>(<span class="st">"Number of exacerbations per patient"</span>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">summarize_glm_count</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">offset =</span> <span class="st">"lgTMATRSK"</span>, <span class="at">covariates =</span> <span class="cn">NULL</span>),</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">distribution =</span> <span class="st">"poisson"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">rate_mean_method =</span> <span class="st">"emmeans"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">var_labels =</span> <span class="st">"Unadjusted exacerbation rate (per year)"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">table_names =</span> <span class="st">"unadj"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"rate"</span>),</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">rate =</span> <span class="st">"Rate"</span>)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  <span class="fu">summarize_glm_count</span>(</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">offset =</span> <span class="st">"lgTMATRSK"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"REGION1"</span>)),</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">distribution =</span> <span class="st">"quasipoisson"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">rate_mean_method =</span> <span class="st">"ppmeans"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted (QP) exacerbation rate (per year)"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">table_names =</span> <span class="st">"adj"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"rate"</span>, <span class="st">"rate_ci"</span>, <span class="st">"rate_ratio"</span>, <span class="st">"rate_ratio_ci"</span>, <span class="st">"pval"</span>),</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-31"><a href="#cb2-31"></a>      <span class="at">rate =</span> <span class="st">"Rate"</span>, <span class="at">rate_ci =</span> <span class="st">"Rate CI"</span>, <span class="at">rate_ratio =</span> <span class="st">"Rate Ratio"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>      <span class="at">rate_ratio_ci =</span> <span class="st">"Rate Ratio CI"</span>, <span class="at">pval =</span> <span class="st">"p value"</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>    )</span>
+<span id="cb2-34"><a href="#cb2-34"></a>  )</span>
+<span id="cb2-35"><a href="#cb2-35"></a></span>
+<span id="cb2-36"><a href="#cb2-36"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="at">df =</span> anl</span>
+<span id="cb2-39"><a href="#cb2-39"></a>)</span>
+<span id="cb2-40"><a href="#cb2-40"></a></span>
+<span id="cb2-41"><a href="#cb2-41"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                B: Placebo         A: Drug X        C: Combination 
+                                                 (N=134)            (N=134)            (N=132)     
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Number of exacerbations per patient                                                                
+  0                                             10 (7.46%)         6 (4.48%)          11 (8.33%)   
+  1                                            25 (18.66%)        21 (15.67%)        14 (10.61%)   
+  2                                            38 (28.36%)        41 (30.60%)        33 (25.00%)   
+  3                                            22 (16.42%)        26 (19.40%)        21 (15.91%)   
+  4                                             13 (9.70%)        18 (13.43%)        30 (22.73%)   
+  5                                             11 (8.21%)         10 (7.46%)         12 (9.09%)   
+  6                                             10 (7.46%)         7 (5.22%)          7 (5.30%)    
+  7                                             3 (2.24%)          4 (2.99%)          3 (2.27%)    
+  8                                             1 (0.75%)          1 (0.75%)          1 (0.76%)    
+  9                                             1 (0.75%)          0 (0.00%)          0 (0.00%)    
+Unadjusted exacerbation rate (per year)                                                            
+  Rate                                            7.2364             8.2148             9.8131     
+Adjusted (QP) exacerbation rate (per year)                                                         
+  Rate                                            2.4550             2.8514             3.4304     
+  Rate CI                                    (1.6194, 3.7219)   (1.8974, 4.2850)   (2.2946, 5.1284)
+  Rate Ratio                                                         1.1615             1.3973     
+  Rate Ratio CI                                                 (0.6462, 2.0877)   (0.7789, 2.5067)
+  p value                                                            0.6169             0.2619     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="ratet01_cache/html/teal_611aa7c752a5cb082d5e1699749436d9">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In Progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ratet01_cache/html/sessioninfo_3c43272547ea1695636fd7a0d743109b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] sandwich_3.0-2     utf8_1.2.3         generics_0.1.3     tidyr_1.3.0       
+ [5] lattice_0.21-8     digest_0.6.33      evaluate_0.21      grid_4.3.1        
+ [9] estimability_1.4.1 mvtnorm_1.2-3      fastmap_1.1.1      jsonlite_1.8.7    
+[13] Matrix_1.6-1.1     backports_1.4.1    brio_1.1.3         survival_3.5-7    
+[17] multcomp_1.4-25    purrr_1.0.2        fansi_1.0.4        scales_1.2.1      
+[21] TH.data_1.1-2      codetools_0.2-19   Rdpack_2.5         cli_3.6.1         
+[25] rlang_1.1.1        rbibutils_2.2.15   munsell_0.5.0      splines_4.3.1     
+[29] yaml_2.3.7         tools_4.3.1        checkmate_2.2.0    coda_0.19-4       
+[33] colorspace_2.1-0   ggplot2_3.4.3      forcats_1.0.0      broom_1.0.5       
+[37] vctrs_0.6.3        R6_2.5.1           zoo_1.8-12         lifecycle_1.0.3   
+[41] emmeans_1.8.8      htmlwidgets_1.6.2  MASS_7.3-60        pkgconfig_2.0.3   
+[45] pillar_1.9.0       gtable_0.3.4       glue_1.6.2         xfun_0.40         
+[49] tibble_3.2.1       tidyselect_1.2.0   rstudioapi_0.15.0  knitr_1.44        
+[53] xtable_1.8-4       htmltools_0.5.6    rmarkdown_2.25     testthat_3.1.10   
+[57] compiler_4.3.1    </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ratet01_cache/html/snapshot_6489e33740f96e2225d2ed3be20335d4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/ratet01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
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+    if (mode === "dark") {
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+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
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+      window.scrollTo(0, 1);
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+        window.scrollTo(0, 0);
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+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
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+    const i = window.document.createElement("i");
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+        button.removeAttribute("data-bs-placement");
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+      button.setAttribute("title", currentTitle);
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+    }, 1000);
+    // clear code selection
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+  });
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+        // rstudio viewer pane
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+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
+        }
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+        modal.show();
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+      return false;
+    });
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+        } else {
+          details.removeAttribute("open");
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+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
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+        if (codeDiv.classList.contains(fromCls)) {
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+      return false;
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+  }
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+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
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+  }
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+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
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+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+          }
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
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+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
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+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
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+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> RATET01</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Event Rate Summary for Recurrent Events</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>This example will focus on data from a single visit "WEEK 1 DAY 8" and a single endpoint "FKSI-FWB".</span>
+<span id="cb8-11"><a href="#cb8-11"></a>Only evaluable populations will be analyzed.</span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a>::: panel-tabset</span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a></span>
+<span id="cb8-19"><a href="#cb8-19"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-20"><a href="#cb8-20"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-21"><a href="#cb8-21"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-22"><a href="#cb8-22"></a></span>
+<span id="cb8-23"><a href="#cb8-23"></a>anl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNE"</span>)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a><span class="co"># Ensure number of exacerbation is a factor and NAs are explicit missing levels.</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>anl<span class="sc">$</span>AVAL_f <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>AVAL)</span>
+<span id="cb8-28"><a href="#cb8-28"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span>
+<span id="cb8-29"><a href="#cb8-29"></a><span class="in">```</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a></span>
+<span id="cb8-31"><a href="#cb8-31"></a><span class="fu">## Customized Table</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"B: Placebo"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="st">"AVAL_f"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">var_labels =</span> <span class="st">"Number of exacerbations per patient"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span>),</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(<span class="st">"count_fraction"</span> <span class="ot">=</span> <span class="st">"xx (xx.xx%)"</span>),</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">.label =</span> <span class="fu">c</span>(<span class="st">"Number of exacerbations per patient"</span>)</span>
+<span id="cb8-42"><a href="#cb8-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">summarize_glm_count</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">offset =</span> <span class="st">"lgTMATRSK"</span>, <span class="at">covariates =</span> <span class="cn">NULL</span>),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">distribution =</span> <span class="st">"poisson"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">rate_mean_method =</span> <span class="st">"emmeans"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">var_labels =</span> <span class="st">"Unadjusted exacerbation rate (per year)"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">table_names =</span> <span class="st">"unadj"</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"rate"</span>),</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">rate =</span> <span class="st">"Rate"</span>)</span>
+<span id="cb8-53"><a href="#cb8-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  <span class="fu">summarize_glm_count</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">arm =</span> <span class="st">"ARM"</span>, <span class="at">offset =</span> <span class="st">"lgTMATRSK"</span>, <span class="at">covariates =</span> <span class="fu">c</span>(<span class="st">"REGION1"</span>)),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>    <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>    <span class="at">distribution =</span> <span class="st">"quasipoisson"</span>,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">rate_mean_method =</span> <span class="st">"ppmeans"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">var_labels =</span> <span class="st">"Adjusted (QP) exacerbation rate (per year)"</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>    <span class="at">table_names =</span> <span class="st">"adj"</span>,</span>
+<span id="cb8-62"><a href="#cb8-62"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"rate"</span>, <span class="st">"rate_ci"</span>, <span class="st">"rate_ratio"</span>, <span class="st">"rate_ratio_ci"</span>, <span class="st">"pval"</span>),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-64"><a href="#cb8-64"></a>      <span class="at">rate =</span> <span class="st">"Rate"</span>, <span class="at">rate_ci =</span> <span class="st">"Rate CI"</span>, <span class="at">rate_ratio =</span> <span class="st">"Rate Ratio"</span>,</span>
+<span id="cb8-65"><a href="#cb8-65"></a>      <span class="at">rate_ratio_ci =</span> <span class="st">"Rate Ratio CI"</span>, <span class="at">pval =</span> <span class="st">"p value"</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a>    )</span>
+<span id="cb8-67"><a href="#cb8-67"></a>  )</span>
+<span id="cb8-68"><a href="#cb8-68"></a></span>
+<span id="cb8-69"><a href="#cb8-69"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="at">df =</span> anl</span>
+<span id="cb8-72"><a href="#cb8-72"></a>)</span>
+<span id="cb8-73"><a href="#cb8-73"></a></span>
+<span id="cb8-74"><a href="#cb8-74"></a>result</span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="in">```</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-78"><a href="#cb8-78"></a></span>
+<span id="cb8-79"><a href="#cb8-79"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-80"><a href="#cb8-80"></a></span>
+<span id="cb8-81"><a href="#cb8-81"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a><span class="co"># In Progress</span></span>
+<span id="cb8-85"><a href="#cb8-85"></a><span class="in">```</span></span>
+<span id="cb8-86"><a href="#cb8-86"></a></span>
+<span id="cb8-87"><a href="#cb8-87"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-88"><a href="#cb8-88"></a></span>
+<span id="cb8-89"><a href="#cb8-89"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/tables/efficacy/rbmit01.html b/stable/tables/efficacy/rbmit01.html
new file mode 100644
index 0000000000..a4064c7287
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+++ b/stable/tables/efficacy/rbmit01.html
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+div.sourceCode
+  {   }
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+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Tables</span></a>
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+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
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+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<div class="quarto-title-block"><div><h1 class="title">RBMIT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Tables for RBMI</p>
+</div>
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+<div class="quarto-title-meta">
+
+    
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+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Draws</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Impute</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Analyze</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Pool</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Create Output</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>We use a publicly available example dataset from an antidepressant clinical trial of an active drug versus placebo from the <code>rbmi</code> package. The relevant endpoint is the Hamilton 17-item depression rating scale (<code>HAMD17</code>) which was assessed at baseline and at weeks 1, 2, 4, and 6. Study drug discontinuation occurred in 24% of subjects from the active drug and 26% of subjects from placebo. All data after study drug discontinuation are missing and there is a single additional intermittent missing observation.</p>
+<div class="cell" data-hash="rbmit01_cache/html/setup_d6f900af065b4dce1223ca3855f5131e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern.rbmi)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>data <span class="ot">&lt;-</span> antidepressant_data</span>
+<span id="cb1-6"><a href="#cb1-6"></a><span class="fu">levels</span>(data<span class="sc">$</span>THERAPY) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"PLACEBO"</span>, <span class="st">"DRUG"</span>) <span class="co"># This is important! The order defines the computation order later</span></span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>missing_var <span class="ot">&lt;-</span> <span class="st">"CHANGE"</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>vars <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="at">id =</span> <span class="st">"PATIENT"</span>,</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="at">visit =</span> <span class="st">"VISIT"</span>,</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">expand_vars =</span> <span class="fu">c</span>(<span class="st">"BASVAL"</span>, <span class="st">"THERAPY"</span>),</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="at">group =</span> <span class="st">"THERAPY"</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>covariates <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="at">draws =</span> <span class="fu">c</span>(<span class="st">"BASVAL*VISIT"</span>, <span class="st">"THERAPY*VISIT"</span>),</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">analyse =</span> <span class="fu">c</span>(<span class="st">"BASVAL"</span>)</span>
+<span id="cb1-18"><a href="#cb1-18"></a>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a>data <span class="ot">&lt;-</span> data <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  dplyr<span class="sc">::</span><span class="fu">select</span>(PATIENT, THERAPY, VISIT, BASVAL, THERAPY, CHANGE) <span class="sc">%&gt;%</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> vars<span class="sc">$</span>id, <span class="sc">~</span> <span class="fu">as.factor</span>(.x))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  dplyr<span class="sc">::</span><span class="fu">arrange</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> <span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)))</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="co"># Use expand_locf to add rows corresponding to visits with missing outcomes to the dataset</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>data_full <span class="ot">&lt;-</span> <span class="fu">do.call</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  expand_locf,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="at">args =</span> <span class="fu">list</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">data =</span> data,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">vars =</span> <span class="fu">c</span>(vars<span class="sc">$</span>expand_vars, vars<span class="sc">$</span>group),</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">group =</span> vars<span class="sc">$</span>id,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">order =</span> <span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>    <span class="fu">append</span>(<span class="fu">lapply</span>(data[<span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)], levels))</span>
+<span id="cb1-35"><a href="#cb1-35"></a>)</span>
+<span id="cb1-36"><a href="#cb1-36"></a></span>
+<span id="cb1-37"><a href="#cb1-37"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(vars<span class="sc">$</span>id)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="sc">!!</span>vars<span class="sc">$</span><span class="at">group :=</span> <span class="fu">Filter</span>(<span class="fu">Negate</span>(is.na), .data[[vars<span class="sc">$</span>group]])[<span class="dv">1</span>])</span>
+<span id="cb1-40"><a href="#cb1-40"></a></span>
+<span id="cb1-41"><a href="#cb1-41"></a><span class="co"># there are duplicates - use first value</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>group, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  dplyr<span class="sc">::</span><span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb1-46"><a href="#cb1-46"></a><span class="co"># need to have a single ID column</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  tidyr<span class="sc">::</span><span class="fu">unite</span>(<span class="st">"TMP_ID"</span>, dplyr<span class="sc">::</span><span class="fu">all_of</span>(vars<span class="sc">$</span>id), <span class="at">sep =</span> <span class="st">"_#_"</span>, <span class="at">remove =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">TMP_ID =</span> <span class="fu">as.factor</span>(TMP_ID))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="creating-intercurrent-event-data" class="level4"><h4 class="anchored" data-anchor-id="creating-intercurrent-event-data">Creating Intercurrent Event Data</h4>
+<p>Set the imputation strategy to <code>"MAR"</code> for each patient with at least one missing observation.</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-1_2e1ca9e5fcd62d95519e577fdf79a382">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>data_ice <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  dplyr<span class="sc">::</span><span class="fu">arrange</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> <span class="fu">c</span>(<span class="st">"TMP_ID"</span>, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="fu">is.na</span>(.data[[missing_var]])) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(TMP_ID) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  dplyr<span class="sc">::</span><span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="fu">all_of</span>(<span class="fu">c</span>(<span class="st">"TMP_ID"</span>, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">strategy =</span> <span class="st">"MAR"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</section>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The <code><a href="https://insightsengineering.github.io/rbmi/reference/draws.html">rbmi::draws()</a></code> function fits the imputation models and stores the corresponding parameter estimates or Bayesian posterior parameter draws. The three main inputs to the <code><a href="https://insightsengineering.github.io/rbmi/reference/draws.html">rbmi::draws()</a></code> function are:</p>
+<ul>
+<li>
+<code>data</code> - The primary longitudinal data.frame containing the outcome variable and all covariates.</li>
+<li>
+<code>data_ice</code> - A data.frame which specifies the first visit affected by an intercurrent event (ICE) and the imputation strategy for handling missing outcome data after the ICE. At most one ICE which is to be imputed by a non-MAR strategy is allowed per subject.</li>
+<li>
+<code>method</code> - The statistical method used to fit the imputation models and to create imputed datasets.</li>
+</ul>
+<section id="define-key-variables" class="level4"><h4 class="anchored" data-anchor-id="define-key-variables">Define Key Variables</h4>
+<p>Define the names of key variables in our dataset and the covariates included in the imputation model using <code><a href="https://insightsengineering.github.io/rbmi/reference/set_vars.html">rbmi::set_vars()</a></code>. Note that the <code>covariates</code> argument can also include interaction terms.</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-2_47bf1a6633f0515fc7e80bd6fa0edaf3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>debug_mode <span class="ot">&lt;-</span> <span class="cn">FALSE</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a></span>
+<span id="cb3-3"><a href="#cb3-3"></a>draws_vars <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">set_vars</span>(</span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="at">outcome =</span> missing_var,</span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="at">visit =</span> vars<span class="sc">$</span>visit,</span>
+<span id="cb3-6"><a href="#cb3-6"></a>  <span class="at">group =</span> vars<span class="sc">$</span>group,</span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="at">covariates =</span> covariates<span class="sc">$</span>draws</span>
+<span id="cb3-8"><a href="#cb3-8"></a>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a>draws_vars<span class="sc">$</span>subjid <span class="ot">&lt;-</span> <span class="st">"TMP_ID"</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p>Define which imputation method to use, then create samples for the imputation parameters by running the <code>draws()</code> function.</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-3_f6ffd86d33197b76de861cec0a446529">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>draws_method <span class="ot">&lt;-</span> <span class="fu">method_bayes</span>()</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>draws_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">draws</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="at">data =</span> data_full,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="at">data_ice =</span> data_ice,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="at">vars =</span> draws_vars,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="at">method =</span> draws_method</span>
+<span id="cb4-8"><a href="#cb4-8"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>
+SAMPLING FOR MODEL 'MMRM' NOW (CHAIN 1).
+Chain 1: 
+Chain 1: Gradient evaluation took 0.000597 seconds
+Chain 1: 1000 transitions using 10 leapfrog steps per transition would take 5.97 seconds.
+Chain 1: Adjust your expectations accordingly!
+Chain 1: 
+Chain 1: 
+Chain 1: Iteration:    1 / 1200 [  0%]  (Warmup)
+Chain 1: Iteration:  120 / 1200 [ 10%]  (Warmup)
+Chain 1: Iteration:  201 / 1200 [ 16%]  (Sampling)
+Chain 1: Iteration:  320 / 1200 [ 26%]  (Sampling)
+Chain 1: Iteration:  440 / 1200 [ 36%]  (Sampling)
+Chain 1: Iteration:  560 / 1200 [ 46%]  (Sampling)
+Chain 1: Iteration:  680 / 1200 [ 56%]  (Sampling)
+Chain 1: Iteration:  800 / 1200 [ 66%]  (Sampling)
+Chain 1: Iteration:  920 / 1200 [ 76%]  (Sampling)
+Chain 1: Iteration: 1040 / 1200 [ 86%]  (Sampling)
+Chain 1: Iteration: 1160 / 1200 [ 96%]  (Sampling)
+Chain 1: Iteration: 1200 / 1200 [100%]  (Sampling)
+Chain 1: 
+Chain 1:  Elapsed Time: 0.893 seconds (Warm-up)
+Chain 1:                3.133 seconds (Sampling)
+Chain 1:                4.026 seconds (Total)
+Chain 1: </code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>The next step is to use the parameters from the imputation model to generate the imputed datasets. This is done via the <code><a href="https://insightsengineering.github.io/rbmi/reference/impute.html">rbmi::impute()</a></code> function. The function only has two key inputs: the imputation model output from <code><a href="https://insightsengineering.github.io/rbmi/reference/draws.html">rbmi::draws()</a></code> and the reference groups relevant to reference-based imputation methods. It’s usage is thus:</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-4_2af5be16287dbf0778e0609770a95d26">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>impute_references <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"DRUG"</span> <span class="ot">=</span> <span class="st">"PLACEBO"</span>, <span class="st">"PLACEBO"</span> <span class="ot">=</span> <span class="st">"PLACEBO"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>impute_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">impute</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>  draws_obj,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="at">references =</span> impute_references</span>
+<span id="cb6-6"><a href="#cb6-6"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The next step is to run the analysis model on each imputed dataset. This is done by defining an analysis function and then calling <code><a href="https://insightsengineering.github.io/rbmi/reference/analyse.html">rbmi::analyse()</a></code> to apply this function to each imputed dataset.</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-5_225ad6a60b189f0606f61fc838d02e9c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># Define analysis model</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>analyse_fun <span class="ot">&lt;-</span> ancova</span>
+<span id="cb7-3"><a href="#cb7-3"></a></span>
+<span id="cb7-4"><a href="#cb7-4"></a>ref_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(impute_obj<span class="sc">$</span>data<span class="sc">$</span>group[[<span class="dv">1</span>]])</span>
+<span id="cb7-5"><a href="#cb7-5"></a><span class="fu">names</span>(ref_levels) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ref"</span>, <span class="st">"alt"</span>)</span>
+<span id="cb7-6"><a href="#cb7-6"></a></span>
+<span id="cb7-7"><a href="#cb7-7"></a>analyse_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">analyse</span>(</span>
+<span id="cb7-8"><a href="#cb7-8"></a>  <span class="at">imputations =</span> impute_obj,</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="at">fun =</span> analyse_fun,</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  <span class="at">vars =</span> rbmi<span class="sc">::</span><span class="fu">set_vars</span>(</span>
+<span id="cb7-11"><a href="#cb7-11"></a>    <span class="at">subjid =</span> <span class="st">"TMP_ID"</span>,</span>
+<span id="cb7-12"><a href="#cb7-12"></a>    <span class="at">outcome =</span> missing_var,</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">visit =</span> vars<span class="sc">$</span>visit,</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="at">group =</span> vars<span class="sc">$</span>group,</span>
+<span id="cb7-15"><a href="#cb7-15"></a>    <span class="at">covariates =</span> covariates<span class="sc">$</span>analyse</span>
+<span id="cb7-16"><a href="#cb7-16"></a>  )</span>
+<span id="cb7-17"><a href="#cb7-17"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>The <code><a href="https://insightsengineering.github.io/rbmi/reference/pool.html">rbmi::pool()</a></code> function can be used to summarize the analysis results across multiple imputed datasets to provide an overall statistic with a standard error, confidence intervals and a p-value for the hypothesis test of the null hypothesis that the effect is equal to 0. Using the <code><a href="https://generics.r-lib.org/reference/tidy.html">broom::tidy()</a></code> function the <code>rbmi</code> final results are reshaped.</p>
+<div class="cell" data-hash="rbmit01_cache/html/unnamed-chunk-6_5516ca5b557f111f8f5c23aab0d916b6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(broom)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>pool_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">pool</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="at">results =</span> analyse_obj,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="at">conf.level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="at">alternative =</span> <span class="fu">c</span>(<span class="st">"two.sided"</span>, <span class="st">"less"</span>, <span class="st">"greater"</span>),</span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="at">type =</span> <span class="fu">c</span>(<span class="st">"percentile"</span>, <span class="st">"normal"</span>)</span>
+<span id="cb8-8"><a href="#cb8-8"></a>)</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>df <span class="ot">&lt;-</span> <span class="fu">tidy</span>(pool_obj)</span>
+<span id="cb8-11"><a href="#cb8-11"></a>df</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>  group       est    se_est lower_cl_est upper_cl_est   est_contr  se_contr
+1   ref -1.615820 0.4862316    -2.575771   -0.6558685          NA        NA
+2   alt -1.707626 0.4749573    -2.645319   -0.7699335 -0.09180645 0.6826279
+3   ref -4.249254 0.6516319    -5.536213   -2.9622946          NA        NA
+4   alt -2.831077 0.6457793    -4.106986   -1.5551687  1.41817668 0.9189337
+5   ref -6.358552 0.7101739    -7.762347   -4.9547560          NA        NA
+6   alt -4.130754 0.6923008    -5.499118   -2.7623890  2.22779812 0.9955083
+7   ref -7.642160 0.8026102    -9.231000   -6.0533202          NA        NA
+8   alt -4.831049 0.7784757    -6.371584   -3.2905138  2.81111124 1.1270640
+  lower_cl_contr upper_cl_contr    p_value relative_reduc visit conf_level
+1             NA             NA         NA             NA     4       0.95
+2     -1.4394968       1.255884 0.89317724     0.05681725     4       0.95
+3             NA             NA         NA             NA     5       0.95
+4     -0.3969026       3.233256 0.12477649    -0.33374722     5       0.95
+5             NA             NA         NA             NA     6       0.95
+6      0.2600937       4.195503 0.02676669    -0.35036251     6       0.95
+7             NA             NA         NA             NA     7       0.95
+8      0.5799592       5.042263 0.01396370    -0.36784249     7       0.95</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Finally, use functions from the <code>rtables</code> and <code>tern</code> packages to generate a nicely formatted <code>rtable</code> object.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rbmit01_cache/html/variant1_94797570ad8dfd340e4386fbbb1b1606">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"group"</span>, <span class="at">ref_group =</span> <span class="fu">levels</span>(df<span class="sc">$</span>group)[<span class="dv">1</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"visit"</span>, <span class="at">split_label =</span> <span class="st">"Visit"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>  <span class="fu">summarize_rbmi</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">build_table</span>(df)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                                       ref                alt       
+—————————————————————————————————————————————————————————————————————————
+4                                                                        
+  Adjusted Mean (SE)                   -1.616 (0.486)     -1.708 (0.475) 
+    95% CI                            (-2.576, -0.656)   (-2.645, -0.770)
+  Difference in Adjusted Means (SE)                       -0.092 (0.683) 
+    95% CI                                               (-1.439, 1.256) 
+    Relative Reduction (%)                                     5.7%      
+    p-value (RBMI)                                            0.8932     
+5                                                                        
+  Adjusted Mean (SE)                   -4.249 (0.652)     -2.831 (0.646) 
+    95% CI                            (-5.536, -2.962)   (-4.107, -1.555)
+  Difference in Adjusted Means (SE)                       1.418 (0.919)  
+    95% CI                                               (-0.397, 3.233) 
+    Relative Reduction (%)                                    -33.4%     
+    p-value (RBMI)                                            0.1248     
+6                                                                        
+  Adjusted Mean (SE)                   -6.359 (0.710)     -4.131 (0.692) 
+    95% CI                            (-7.762, -4.955)   (-5.499, -2.762)
+  Difference in Adjusted Means (SE)                       2.228 (0.996)  
+    95% CI                                                (0.260, 4.196) 
+    Relative Reduction (%)                                    -35.0%     
+    p-value (RBMI)                                            0.0268     
+7                                                                        
+  Adjusted Mean (SE)                   -7.642 (0.803)     -4.831 (0.778) 
+    95% CI                            (-9.231, -6.053)   (-6.372, -3.291)
+  Difference in Adjusted Means (SE)                       2.811 (1.127)  
+    95% CI                                                (0.580, 5.042) 
+    Relative Reduction (%)                                    -36.8%     
+    p-value (RBMI)                                            0.0140     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rbmit01_cache/html/sessioninfo_61c5f3a04f53697339628bd04fe892c7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] broom_1.0.5      dplyr_1.1.3      tern.rbmi_0.1.2  tern_0.9.0      
+[5] rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2 rbmi_1.2.5      
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0    loo_2.6.0           fastmap_1.1.1      
+ [4] TH.data_1.1-2       digest_0.6.33       estimability_1.4.1 
+ [7] lifecycle_1.0.3     StanHeaders_2.26.28 survival_3.5-7     
+[10] processx_3.8.2      compiler_4.3.1      rlang_1.1.1        
+[13] tools_4.3.1         utf8_1.2.3          yaml_2.3.7         
+[16] mmrm_0.2.2          knitr_1.44          prettyunits_1.1.1  
+[19] htmlwidgets_1.6.2   pkgbuild_1.4.2      multcomp_1.4-25    
+[22] withr_2.5.0         purrr_1.0.2         numDeriv_2016.8-1.1
+[25] grid_4.3.1          stats4_4.3.1        fansi_1.0.4        
+[28] xtable_1.8-4        colorspace_2.1-0    inline_0.3.19      
+[31] ggplot2_3.4.3       emmeans_1.8.8       scales_1.2.1       
+[34] MASS_7.3-60         cli_3.6.1           mvtnorm_1.2-3      
+[37] rmarkdown_2.25      crayon_1.5.2        generics_0.1.3     
+[40] RcppParallel_5.1.7  rstudioapi_0.15.0   rstan_2.26.23      
+[43] stringr_1.5.0       splines_4.3.1       assertthat_0.2.1   
+[46] parallel_4.3.1      matrixStats_1.0.0   vctrs_0.6.3        
+[49] Matrix_1.6-1.1      sandwich_3.0-2      jsonlite_1.8.7     
+[52] callr_3.7.3         testthat_3.1.10     tidyr_1.3.0        
+[55] glue_1.6.2          codetools_0.2-19    ps_1.7.5           
+[58] stringi_1.7.12      gtable_0.3.4        QuickJSR_1.0.6     
+[61] munsell_0.5.0       tibble_3.2.1        pillar_1.9.0       
+[64] htmltools_0.5.6     brio_1.1.3          R6_2.5.1           
+[67] TMB_1.9.6           Rdpack_2.5          evaluate_0.21      
+[70] lattice_0.21-8      rbibutils_2.2.15    backports_1.4.1    
+[73] Rcpp_1.0.11         coda_0.19-4         gridExtra_2.3      
+[76] nlme_3.1-163        checkmate_2.2.0     xfun_0.40          
+[79] zoo_1.8-12          pkgconfig_2.0.3    </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rbmit01_cache/html/snapshot_1a40bbb540e7d05e676231ed00de1724">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/rbmit01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
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+  const toggleBodyColorPrimary = () => {
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+    if (bsSheetEl) {
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+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
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+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
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+  clipboard.on('success', function(e) {
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+    button.blur();
+    // flash "checked"
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+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
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+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
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+      delay: 100,
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+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
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+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
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+  };
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> RBMIT01</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Tables for RBMI</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>::: panel-tabset</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a>We use a publicly available example dataset from an antidepressant clinical trial of an active drug versus placebo from the <span class="in">`rbmi`</span> package.</span>
+<span id="cb15-14"><a href="#cb15-14"></a>The relevant endpoint is the Hamilton 17-item depression rating scale (<span class="in">`HAMD17`</span>) which was assessed at baseline and at weeks 1, 2, 4, and 6.</span>
+<span id="cb15-15"><a href="#cb15-15"></a>Study drug discontinuation occurred in 24% of subjects from the active drug and 26% of subjects from placebo.</span>
+<span id="cb15-16"><a href="#cb15-16"></a>All data after study drug discontinuation are missing and there is a single additional intermittent missing observation.</span>
+<span id="cb15-17"><a href="#cb15-17"></a></span>
+<span id="cb15-18"><a href="#cb15-18"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-19"><a href="#cb15-19"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-20"><a href="#cb15-20"></a></span>
+<span id="cb15-21"><a href="#cb15-21"></a><span class="fu">library</span>(tern.rbmi)</span>
+<span id="cb15-22"><a href="#cb15-22"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-23"><a href="#cb15-23"></a><span class="fu">set.seed</span>(<span class="dv">123</span>)</span>
+<span id="cb15-24"><a href="#cb15-24"></a></span>
+<span id="cb15-25"><a href="#cb15-25"></a>data <span class="ot">&lt;-</span> antidepressant_data</span>
+<span id="cb15-26"><a href="#cb15-26"></a><span class="fu">levels</span>(data<span class="sc">$</span>THERAPY) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"PLACEBO"</span>, <span class="st">"DRUG"</span>) <span class="co"># This is important! The order defines the computation order later</span></span>
+<span id="cb15-27"><a href="#cb15-27"></a></span>
+<span id="cb15-28"><a href="#cb15-28"></a>missing_var <span class="ot">&lt;-</span> <span class="st">"CHANGE"</span></span>
+<span id="cb15-29"><a href="#cb15-29"></a>vars <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb15-30"><a href="#cb15-30"></a>  <span class="at">id =</span> <span class="st">"PATIENT"</span>,</span>
+<span id="cb15-31"><a href="#cb15-31"></a>  <span class="at">visit =</span> <span class="st">"VISIT"</span>,</span>
+<span id="cb15-32"><a href="#cb15-32"></a>  <span class="at">expand_vars =</span> <span class="fu">c</span>(<span class="st">"BASVAL"</span>, <span class="st">"THERAPY"</span>),</span>
+<span id="cb15-33"><a href="#cb15-33"></a>  <span class="at">group =</span> <span class="st">"THERAPY"</span></span>
+<span id="cb15-34"><a href="#cb15-34"></a>)</span>
+<span id="cb15-35"><a href="#cb15-35"></a>covariates <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb15-36"><a href="#cb15-36"></a>  <span class="at">draws =</span> <span class="fu">c</span>(<span class="st">"BASVAL*VISIT"</span>, <span class="st">"THERAPY*VISIT"</span>),</span>
+<span id="cb15-37"><a href="#cb15-37"></a>  <span class="at">analyse =</span> <span class="fu">c</span>(<span class="st">"BASVAL"</span>)</span>
+<span id="cb15-38"><a href="#cb15-38"></a>)</span>
+<span id="cb15-39"><a href="#cb15-39"></a></span>
+<span id="cb15-40"><a href="#cb15-40"></a>data <span class="ot">&lt;-</span> data <span class="sc">%&gt;%</span></span>
+<span id="cb15-41"><a href="#cb15-41"></a>  dplyr<span class="sc">::</span><span class="fu">select</span>(PATIENT, THERAPY, VISIT, BASVAL, THERAPY, CHANGE) <span class="sc">%&gt;%</span></span>
+<span id="cb15-42"><a href="#cb15-42"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> vars<span class="sc">$</span>id, <span class="sc">~</span> <span class="fu">as.factor</span>(.x))) <span class="sc">%&gt;%</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a>  dplyr<span class="sc">::</span><span class="fu">arrange</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> <span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)))</span>
+<span id="cb15-44"><a href="#cb15-44"></a></span>
+<span id="cb15-45"><a href="#cb15-45"></a><span class="co"># Use expand_locf to add rows corresponding to visits with missing outcomes to the dataset</span></span>
+<span id="cb15-46"><a href="#cb15-46"></a>data_full <span class="ot">&lt;-</span> <span class="fu">do.call</span>(</span>
+<span id="cb15-47"><a href="#cb15-47"></a>  expand_locf,</span>
+<span id="cb15-48"><a href="#cb15-48"></a>  <span class="at">args =</span> <span class="fu">list</span>(</span>
+<span id="cb15-49"><a href="#cb15-49"></a>    <span class="at">data =</span> data,</span>
+<span id="cb15-50"><a href="#cb15-50"></a>    <span class="at">vars =</span> <span class="fu">c</span>(vars<span class="sc">$</span>expand_vars, vars<span class="sc">$</span>group),</span>
+<span id="cb15-51"><a href="#cb15-51"></a>    <span class="at">group =</span> vars<span class="sc">$</span>id,</span>
+<span id="cb15-52"><a href="#cb15-52"></a>    <span class="at">order =</span> <span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)</span>
+<span id="cb15-53"><a href="#cb15-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-54"><a href="#cb15-54"></a>    <span class="fu">append</span>(<span class="fu">lapply</span>(data[<span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>visit)], levels))</span>
+<span id="cb15-55"><a href="#cb15-55"></a>)</span>
+<span id="cb15-56"><a href="#cb15-56"></a></span>
+<span id="cb15-57"><a href="#cb15-57"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb15-58"><a href="#cb15-58"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(vars<span class="sc">$</span>id)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-59"><a href="#cb15-59"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="sc">!!</span>vars<span class="sc">$</span><span class="at">group :=</span> <span class="fu">Filter</span>(<span class="fu">Negate</span>(is.na), .data[[vars<span class="sc">$</span>group]])[<span class="dv">1</span>])</span>
+<span id="cb15-60"><a href="#cb15-60"></a></span>
+<span id="cb15-61"><a href="#cb15-61"></a><span class="co"># there are duplicates - use first value</span></span>
+<span id="cb15-62"><a href="#cb15-62"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb15-63"><a href="#cb15-63"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="fu">c</span>(vars<span class="sc">$</span>id, vars<span class="sc">$</span>group, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb15-64"><a href="#cb15-64"></a>  dplyr<span class="sc">::</span><span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-65"><a href="#cb15-65"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>()</span>
+<span id="cb15-66"><a href="#cb15-66"></a><span class="co"># need to have a single ID column</span></span>
+<span id="cb15-67"><a href="#cb15-67"></a>data_full <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb15-68"><a href="#cb15-68"></a>  tidyr<span class="sc">::</span><span class="fu">unite</span>(<span class="st">"TMP_ID"</span>, dplyr<span class="sc">::</span><span class="fu">all_of</span>(vars<span class="sc">$</span>id), <span class="at">sep =</span> <span class="st">"_#_"</span>, <span class="at">remove =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-69"><a href="#cb15-69"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">TMP_ID =</span> <span class="fu">as.factor</span>(TMP_ID))</span>
+<span id="cb15-70"><a href="#cb15-70"></a><span class="in">```</span></span>
+<span id="cb15-71"><a href="#cb15-71"></a></span>
+<span id="cb15-72"><a href="#cb15-72"></a><span class="fu">#### Creating Intercurrent Event Data</span></span>
+<span id="cb15-73"><a href="#cb15-73"></a></span>
+<span id="cb15-74"><a href="#cb15-74"></a>Set the imputation strategy to <span class="in">`"MAR"`</span> for each patient with at least one missing observation.</span>
+<span id="cb15-75"><a href="#cb15-75"></a></span>
+<span id="cb15-78"><a href="#cb15-78"></a><span class="in">```{r}</span></span>
+<span id="cb15-79"><a href="#cb15-79"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-80"><a href="#cb15-80"></a></span>
+<span id="cb15-81"><a href="#cb15-81"></a>data_ice <span class="ot">&lt;-</span> data_full <span class="sc">%&gt;%</span></span>
+<span id="cb15-82"><a href="#cb15-82"></a>  dplyr<span class="sc">::</span><span class="fu">arrange</span>(dplyr<span class="sc">::</span><span class="fu">across</span>(<span class="at">.cols =</span> <span class="fu">c</span>(<span class="st">"TMP_ID"</span>, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb15-83"><a href="#cb15-83"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="fu">is.na</span>(.data[[missing_var]])) <span class="sc">%&gt;%</span></span>
+<span id="cb15-84"><a href="#cb15-84"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(TMP_ID) <span class="sc">%&gt;%</span></span>
+<span id="cb15-85"><a href="#cb15-85"></a>  dplyr<span class="sc">::</span><span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-86"><a href="#cb15-86"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-87"><a href="#cb15-87"></a>  dplyr<span class="sc">::</span><span class="fu">select</span>(<span class="fu">all_of</span>(<span class="fu">c</span>(<span class="st">"TMP_ID"</span>, vars<span class="sc">$</span>visit))) <span class="sc">%&gt;%</span></span>
+<span id="cb15-88"><a href="#cb15-88"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">strategy =</span> <span class="st">"MAR"</span>)</span>
+<span id="cb15-89"><a href="#cb15-89"></a><span class="in">```</span></span>
+<span id="cb15-90"><a href="#cb15-90"></a></span>
+<span id="cb15-91"><a href="#cb15-91"></a><span class="fu">## Draws</span></span>
+<span id="cb15-92"><a href="#cb15-92"></a></span>
+<span id="cb15-93"><a href="#cb15-93"></a>The <span class="in">`rbmi::draws()`</span> function fits the imputation models and stores the corresponding parameter estimates or Bayesian posterior parameter draws.</span>
+<span id="cb15-94"><a href="#cb15-94"></a>The three main inputs to the <span class="in">`rbmi::draws()`</span> function are:</span>
+<span id="cb15-95"><a href="#cb15-95"></a></span>
+<span id="cb15-96"><a href="#cb15-96"></a><span class="ss">-   </span><span class="in">`data`</span> - The primary longitudinal data.frame containing the outcome variable and all covariates.</span>
+<span id="cb15-97"><a href="#cb15-97"></a><span class="ss">-   </span><span class="in">`data_ice`</span> - A data.frame which specifies the first visit affected by an intercurrent event (ICE) and the imputation strategy for handling missing outcome data after the ICE. At most one ICE which is to be imputed by a non-MAR strategy is allowed per subject.</span>
+<span id="cb15-98"><a href="#cb15-98"></a><span class="ss">-   </span><span class="in">`method`</span> - The statistical method used to fit the imputation models and to create imputed datasets.</span>
+<span id="cb15-99"><a href="#cb15-99"></a></span>
+<span id="cb15-100"><a href="#cb15-100"></a><span class="fu">#### Define Key Variables</span></span>
+<span id="cb15-101"><a href="#cb15-101"></a></span>
+<span id="cb15-102"><a href="#cb15-102"></a>Define the names of key variables in our dataset and the covariates included in the imputation model using <span class="in">`rbmi::set_vars()`</span>.</span>
+<span id="cb15-103"><a href="#cb15-103"></a>Note that the <span class="in">`covariates`</span> argument can also include interaction terms.</span>
+<span id="cb15-104"><a href="#cb15-104"></a></span>
+<span id="cb15-107"><a href="#cb15-107"></a><span class="in">```{r}</span></span>
+<span id="cb15-108"><a href="#cb15-108"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-109"><a href="#cb15-109"></a></span>
+<span id="cb15-110"><a href="#cb15-110"></a>debug_mode <span class="ot">&lt;-</span> <span class="cn">FALSE</span></span>
+<span id="cb15-111"><a href="#cb15-111"></a></span>
+<span id="cb15-112"><a href="#cb15-112"></a>draws_vars <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">set_vars</span>(</span>
+<span id="cb15-113"><a href="#cb15-113"></a>  <span class="at">outcome =</span> missing_var,</span>
+<span id="cb15-114"><a href="#cb15-114"></a>  <span class="at">visit =</span> vars<span class="sc">$</span>visit,</span>
+<span id="cb15-115"><a href="#cb15-115"></a>  <span class="at">group =</span> vars<span class="sc">$</span>group,</span>
+<span id="cb15-116"><a href="#cb15-116"></a>  <span class="at">covariates =</span> covariates<span class="sc">$</span>draws</span>
+<span id="cb15-117"><a href="#cb15-117"></a>)</span>
+<span id="cb15-118"><a href="#cb15-118"></a>draws_vars<span class="sc">$</span>subjid <span class="ot">&lt;-</span> <span class="st">"TMP_ID"</span></span>
+<span id="cb15-119"><a href="#cb15-119"></a><span class="in">```</span></span>
+<span id="cb15-120"><a href="#cb15-120"></a></span>
+<span id="cb15-121"><a href="#cb15-121"></a>Define which imputation method to use, then create samples for the imputation parameters by running the <span class="in">`draws()`</span> function.</span>
+<span id="cb15-122"><a href="#cb15-122"></a></span>
+<span id="cb15-123"><a href="#cb15-123"></a><span class="in">```{r, warning=FALSE}</span></span>
+<span id="cb15-124"><a href="#cb15-124"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-125"><a href="#cb15-125"></a></span>
+<span id="cb15-126"><a href="#cb15-126"></a>draws_method <span class="ot">&lt;-</span> <span class="fu">method_bayes</span>()</span>
+<span id="cb15-127"><a href="#cb15-127"></a></span>
+<span id="cb15-128"><a href="#cb15-128"></a>draws_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">draws</span>(</span>
+<span id="cb15-129"><a href="#cb15-129"></a>  <span class="at">data =</span> data_full,</span>
+<span id="cb15-130"><a href="#cb15-130"></a>  <span class="at">data_ice =</span> data_ice,</span>
+<span id="cb15-131"><a href="#cb15-131"></a>  <span class="at">vars =</span> draws_vars,</span>
+<span id="cb15-132"><a href="#cb15-132"></a>  <span class="at">method =</span> draws_method</span>
+<span id="cb15-133"><a href="#cb15-133"></a>)</span>
+<span id="cb15-134"><a href="#cb15-134"></a><span class="in">```</span></span>
+<span id="cb15-135"><a href="#cb15-135"></a></span>
+<span id="cb15-136"><a href="#cb15-136"></a><span class="fu">## Impute</span></span>
+<span id="cb15-137"><a href="#cb15-137"></a></span>
+<span id="cb15-138"><a href="#cb15-138"></a>The next step is to use the parameters from the imputation model to generate the imputed datasets.</span>
+<span id="cb15-139"><a href="#cb15-139"></a>This is done via the <span class="in">`rbmi::impute()`</span> function.</span>
+<span id="cb15-140"><a href="#cb15-140"></a>The function only has two key inputs: the imputation model output from <span class="in">`rbmi::draws()`</span> and the reference groups relevant to reference-based imputation methods.</span>
+<span id="cb15-141"><a href="#cb15-141"></a>It's usage is thus:</span>
+<span id="cb15-142"><a href="#cb15-142"></a></span>
+<span id="cb15-145"><a href="#cb15-145"></a><span class="in">```{r}</span></span>
+<span id="cb15-146"><a href="#cb15-146"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-147"><a href="#cb15-147"></a></span>
+<span id="cb15-148"><a href="#cb15-148"></a>impute_references <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"DRUG"</span> <span class="ot">=</span> <span class="st">"PLACEBO"</span>, <span class="st">"PLACEBO"</span> <span class="ot">=</span> <span class="st">"PLACEBO"</span>)</span>
+<span id="cb15-149"><a href="#cb15-149"></a></span>
+<span id="cb15-150"><a href="#cb15-150"></a>impute_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">impute</span>(</span>
+<span id="cb15-151"><a href="#cb15-151"></a>  draws_obj,</span>
+<span id="cb15-152"><a href="#cb15-152"></a>  <span class="at">references =</span> impute_references</span>
+<span id="cb15-153"><a href="#cb15-153"></a>)</span>
+<span id="cb15-154"><a href="#cb15-154"></a><span class="in">```</span></span>
+<span id="cb15-155"><a href="#cb15-155"></a></span>
+<span id="cb15-156"><a href="#cb15-156"></a><span class="fu">## Analyze</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a></span>
+<span id="cb15-158"><a href="#cb15-158"></a>The next step is to run the analysis model on each imputed dataset.</span>
+<span id="cb15-159"><a href="#cb15-159"></a>This is done by defining an analysis function and then calling <span class="in">`rbmi::analyse()`</span> to apply this function to each imputed dataset.</span>
+<span id="cb15-160"><a href="#cb15-160"></a></span>
+<span id="cb15-163"><a href="#cb15-163"></a><span class="in">```{r}</span></span>
+<span id="cb15-164"><a href="#cb15-164"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-165"><a href="#cb15-165"></a></span>
+<span id="cb15-166"><a href="#cb15-166"></a><span class="co"># Define analysis model</span></span>
+<span id="cb15-167"><a href="#cb15-167"></a>analyse_fun <span class="ot">&lt;-</span> ancova</span>
+<span id="cb15-168"><a href="#cb15-168"></a></span>
+<span id="cb15-169"><a href="#cb15-169"></a>ref_levels <span class="ot">&lt;-</span> <span class="fu">levels</span>(impute_obj<span class="sc">$</span>data<span class="sc">$</span>group[[<span class="dv">1</span>]])</span>
+<span id="cb15-170"><a href="#cb15-170"></a><span class="fu">names</span>(ref_levels) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"ref"</span>, <span class="st">"alt"</span>)</span>
+<span id="cb15-171"><a href="#cb15-171"></a></span>
+<span id="cb15-172"><a href="#cb15-172"></a>analyse_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">analyse</span>(</span>
+<span id="cb15-173"><a href="#cb15-173"></a>  <span class="at">imputations =</span> impute_obj,</span>
+<span id="cb15-174"><a href="#cb15-174"></a>  <span class="at">fun =</span> analyse_fun,</span>
+<span id="cb15-175"><a href="#cb15-175"></a>  <span class="at">vars =</span> rbmi<span class="sc">::</span><span class="fu">set_vars</span>(</span>
+<span id="cb15-176"><a href="#cb15-176"></a>    <span class="at">subjid =</span> <span class="st">"TMP_ID"</span>,</span>
+<span id="cb15-177"><a href="#cb15-177"></a>    <span class="at">outcome =</span> missing_var,</span>
+<span id="cb15-178"><a href="#cb15-178"></a>    <span class="at">visit =</span> vars<span class="sc">$</span>visit,</span>
+<span id="cb15-179"><a href="#cb15-179"></a>    <span class="at">group =</span> vars<span class="sc">$</span>group,</span>
+<span id="cb15-180"><a href="#cb15-180"></a>    <span class="at">covariates =</span> covariates<span class="sc">$</span>analyse</span>
+<span id="cb15-181"><a href="#cb15-181"></a>  )</span>
+<span id="cb15-182"><a href="#cb15-182"></a>)</span>
+<span id="cb15-183"><a href="#cb15-183"></a><span class="in">```</span></span>
+<span id="cb15-184"><a href="#cb15-184"></a></span>
+<span id="cb15-185"><a href="#cb15-185"></a><span class="fu">## Pool</span></span>
+<span id="cb15-186"><a href="#cb15-186"></a></span>
+<span id="cb15-187"><a href="#cb15-187"></a>The <span class="in">`rbmi::pool()`</span> function can be used to summarize the analysis results across multiple imputed datasets to provide an overall statistic with a standard error, confidence intervals and a p-value for the hypothesis test of the null hypothesis that the effect is equal to 0.</span>
+<span id="cb15-188"><a href="#cb15-188"></a>Using the <span class="in">`broom::tidy()`</span> function the <span class="in">`rbmi`</span> final results are reshaped.</span>
+<span id="cb15-189"><a href="#cb15-189"></a></span>
+<span id="cb15-192"><a href="#cb15-192"></a><span class="in">```{r}</span></span>
+<span id="cb15-193"><a href="#cb15-193"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-194"><a href="#cb15-194"></a></span>
+<span id="cb15-195"><a href="#cb15-195"></a><span class="fu">library</span>(broom)</span>
+<span id="cb15-196"><a href="#cb15-196"></a></span>
+<span id="cb15-197"><a href="#cb15-197"></a>pool_obj <span class="ot">&lt;-</span> rbmi<span class="sc">::</span><span class="fu">pool</span>(</span>
+<span id="cb15-198"><a href="#cb15-198"></a>  <span class="at">results =</span> analyse_obj,</span>
+<span id="cb15-199"><a href="#cb15-199"></a>  <span class="at">conf.level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb15-200"><a href="#cb15-200"></a>  <span class="at">alternative =</span> <span class="fu">c</span>(<span class="st">"two.sided"</span>, <span class="st">"less"</span>, <span class="st">"greater"</span>),</span>
+<span id="cb15-201"><a href="#cb15-201"></a>  <span class="at">type =</span> <span class="fu">c</span>(<span class="st">"percentile"</span>, <span class="st">"normal"</span>)</span>
+<span id="cb15-202"><a href="#cb15-202"></a>)</span>
+<span id="cb15-203"><a href="#cb15-203"></a></span>
+<span id="cb15-204"><a href="#cb15-204"></a>df <span class="ot">&lt;-</span> <span class="fu">tidy</span>(pool_obj)</span>
+<span id="cb15-205"><a href="#cb15-205"></a>df</span>
+<span id="cb15-206"><a href="#cb15-206"></a><span class="in">```</span></span>
+<span id="cb15-207"><a href="#cb15-207"></a></span>
+<span id="cb15-208"><a href="#cb15-208"></a><span class="fu">## Create Output</span></span>
+<span id="cb15-209"><a href="#cb15-209"></a></span>
+<span id="cb15-210"><a href="#cb15-210"></a>Finally, use functions from the <span class="in">`rtables`</span> and <span class="in">`tern`</span> packages to generate a nicely formatted <span class="in">`rtable`</span> object.</span>
+<span id="cb15-211"><a href="#cb15-211"></a></span>
+<span id="cb15-212"><a href="#cb15-212"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb15-213"><a href="#cb15-213"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-214"><a href="#cb15-214"></a>  <span class="fu">split_cols_by</span>(<span class="st">"group"</span>, <span class="at">ref_group =</span> <span class="fu">levels</span>(df<span class="sc">$</span>group)[<span class="dv">1</span>]) <span class="sc">%&gt;%</span></span>
+<span id="cb15-215"><a href="#cb15-215"></a>  <span class="fu">split_rows_by</span>(<span class="st">"visit"</span>, <span class="at">split_label =</span> <span class="st">"Visit"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-216"><a href="#cb15-216"></a>  <span class="fu">summarize_rbmi</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb15-217"><a href="#cb15-217"></a>  <span class="fu">build_table</span>(df)</span>
+<span id="cb15-218"><a href="#cb15-218"></a>result</span>
+<span id="cb15-219"><a href="#cb15-219"></a><span class="in">```</span></span>
+<span id="cb15-220"><a href="#cb15-220"></a></span>
+<span id="cb15-221"><a href="#cb15-221"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-222"><a href="#cb15-222"></a></span>
+<span id="cb15-223"><a href="#cb15-223"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-224"><a href="#cb15-224"></a></span>
+<span id="cb15-225"><a href="#cb15-225"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+ <span class="menu-text">AET06</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RSPT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Best Overall Response</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Modifying Analysis Details like Type of <br> Confidence Interval, Alpha Level, Test Statistic</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with <br> Stratified Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table Modifying the Definition <br> of Overall Response</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Table Defining New <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="rspt01_cache/html/setup_74e10604cff26e79530e38caeb5f855b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>anl_adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)</span>
+<span id="cb1-15"><a href="#cb1-15"></a>anl_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, STRATA1)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p>Data pre-processing is done to label the analysis value (<code>AVALC</code>) so as to improve the readability of the output table. In addition, the <em>response</em> is binary defined (<code>is_rsp</code>, responder yes/no) depending on the analysis value. Finally, for comparison purposes, the reference arm is specified.</p>
+<div class="cell" data-hash="rspt01_cache/html/unnamed-chunk-1_fae0653a48de06933ac86719a24f2202">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Pre-Processing</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">d_onco_rsp_label</span>(AVALC)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The tabulation layout is built in layers for the analysis of overall response and applied to the pre-processed dataset.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant1_64b09b49cd5abfcc9f9a838a582f9ab4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>lyt_01 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb3-4"><a href="#cb3-4"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb3-5"><a href="#cb3-5"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb3-6"><a href="#cb3-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-7"><a href="#cb3-7"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb3-8"><a href="#cb3-8"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb3-9"><a href="#cb3-9"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb3-10"><a href="#cb3-10"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb3-11"><a href="#cb3-11"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb3-12"><a href="#cb3-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-13"><a href="#cb3-13"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb3-14"><a href="#cb3-14"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb3-15"><a href="#cb3-15"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_diff"</span></span>
+<span id="cb3-16"><a href="#cb3-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-17"><a href="#cb3-17"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb3-18"><a href="#cb3-18"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb3-19"><a href="#cb3-19"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb3-20"><a href="#cb3-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb3-21"><a href="#cb3-21"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb3-22"><a href="#cb3-22"></a></span>
+<span id="cb3-23"><a href="#cb3-23"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb3-24"><a href="#cb3-24"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X          B: Placebo         C: Combination  
+                                        (N=134)            (N=134)              (N=132)      
+—————————————————————————————————————————————————————————————————————————————————————————————
+Responders                            100 (74.6%)         84 (62.7%)           81 (61.4%)    
+95% CI (Wald, with correction)        (66.9, 82.4)       (54.1, 71.2)         (52.7, 70.0)   
+Unstratified Analysis                                                                        
+  Difference in Response rate (%)                           -11.9                -13.3       
+    95% CI (Wald, with correction)                      (-23.7, -0.2)        (-25.1, -1.4)   
+  p-value (Chi-Squared Test)                                0.0351               0.0204      
+Odds Ratio (95% CI)                                   0.57 (0.34 - 0.96)   0.54 (0.32 - 0.91)
+Complete Response (CR)                 60 (44.8%)         47 (35.1%)           57 (43.2%)    
+  95% CI (Wald, with correction)     (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  
+Partial Response (PR)                  40 (29.9%)         37 (27.6%)           24 (18.2%)    
+  95% CI (Wald, with correction)     (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  
+Stable Disease (SD)                     9 (6.7%)          22 (16.4%)           13 (9.8%)     
+  95% CI (Wald, with correction)     (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   
+Progressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    
+  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  
+Not Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     
+  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Remove (or add) rows of results by removing/adding the corresponding layers from the layout. For instance, the odds-ratio row is removed by simply removing the <code>estimate_odds_ratio</code> call:</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant2_87998f997d4074443abea45eb6209565">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>lyt_02 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb5-4"><a href="#cb5-4"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb5-5"><a href="#cb5-5"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb5-6"><a href="#cb5-6"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-7"><a href="#cb5-7"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb5-8"><a href="#cb5-8"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb5-9"><a href="#cb5-9"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb5-10"><a href="#cb5-10"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb5-11"><a href="#cb5-11"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-13"><a href="#cb5-13"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb5-14"><a href="#cb5-14"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb5-15"><a href="#cb5-15"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb5-16"><a href="#cb5-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb5-17"><a href="#cb5-17"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb5-18"><a href="#cb5-18"></a></span>
+<span id="cb5-19"><a href="#cb5-19"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_02, <span class="at">df =</span> anl)</span>
+<span id="cb5-20"><a href="#cb5-20"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X        B: Placebo     C: Combination
+                                        (N=134)          (N=134)          (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————
+Responders                            100 (74.6%)       84 (62.7%)       81 (61.4%)  
+95% CI (Wald, with correction)        (66.9, 82.4)     (54.1, 71.2)     (52.7, 70.0) 
+Unstratified Analysis                                                                
+  Difference in Response rate (%)                         -11.9            -13.3     
+    95% CI (Wald, with correction)                    (-23.7, -0.2)    (-25.1, -1.4) 
+  p-value (Chi-Squared Test)                              0.0351           0.0204    
+Complete Response (CR)                 60 (44.8%)       47 (35.1%)       57 (43.2%)  
+  95% CI (Wald, with correction)     (35.98, 53.57)   (26.62, 43.53)   (34.35, 52.01)
+Partial Response (PR)                  40 (29.9%)       37 (27.6%)       24 (18.2%)  
+  95% CI (Wald, with correction)     (21.73, 37.97)   (19.67, 35.55)   (11.22, 25.14)
+Stable Disease (SD)                     9 (6.7%)        22 (16.4%)       13 (9.8%)   
+  95% CI (Wald, with correction)     (2.11, 11.33)    (9.77, 23.06)    (4.39, 15.31) 
+Progressive Disease (PD)               24 (17.9%)       16 (11.9%)       33 (25.0%)  
+  95% CI (Wald, with correction)     (11.05, 24.78)   (6.08, 17.80)    (17.23, 32.77)
+Not Evaluable (NE)                      1 (0.7%)        12 (9.0%)         5 (3.8%)   
+  95% CI (Wald, with correction)      (0.00, 2.58)    (3.75, 14.16)     (0.15, 7.42) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The confidence level is controlled by the <code>conf_level</code> parameter to the estimation functions. Similarly, the methods for tests and confidence interval can be modified (see <code>?estimate_proportion_diff</code>).</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant3_50a2ea2689290665fa015a169bf20fc8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.90</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>lyt_03 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-4"><a href="#cb7-4"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb7-5"><a href="#cb7-5"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb7-6"><a href="#cb7-6"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb7-7"><a href="#cb7-7"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb7-8"><a href="#cb7-8"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb7-9"><a href="#cb7-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-10"><a href="#cb7-10"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb7-11"><a href="#cb7-11"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb7-12"><a href="#cb7-12"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb7-14"><a href="#cb7-14"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb7-15"><a href="#cb7-15"></a>    <span class="at">method =</span> <span class="st">"ha"</span>,</span>
+<span id="cb7-16"><a href="#cb7-16"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb7-17"><a href="#cb7-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-18"><a href="#cb7-18"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb7-19"><a href="#cb7-19"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb7-20"><a href="#cb7-20"></a>    <span class="at">method =</span> <span class="st">"fisher"</span>,</span>
+<span id="cb7-21"><a href="#cb7-21"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb7-22"><a href="#cb7-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-23"><a href="#cb7-23"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb7-24"><a href="#cb7-24"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb7-25"><a href="#cb7-25"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb7-26"><a href="#cb7-26"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb7-27"><a href="#cb7-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-28"><a href="#cb7-28"></a>  <span class="fu">estimate_multinomial_response</span>(</span>
+<span id="cb7-29"><a href="#cb7-29"></a>    <span class="at">var =</span> <span class="st">"rsp_lab"</span>,</span>
+<span id="cb7-30"><a href="#cb7-30"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb7-31"><a href="#cb7-31"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span></span>
+<span id="cb7-32"><a href="#cb7-32"></a>  )</span>
+<span id="cb7-33"><a href="#cb7-33"></a></span>
+<span id="cb7-34"><a href="#cb7-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_03, <span class="at">df =</span> anl)</span>
+<span id="cb7-35"><a href="#cb7-35"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                      A: Drug X          B: Placebo         C: Combination  
+                                       (N=134)            (N=134)              (N=132)      
+————————————————————————————————————————————————————————————————————————————————————————————
+Responders                           100 (74.6%)         84 (62.7%)           81 (61.4%)    
+90% CI (Clopper-Pearson)             (67.7, 80.7)       (55.3, 69.7)         (53.9, 68.5)   
+Unstratified Analysis                                                                       
+  Difference in Response rate (%)                          -11.9                -13.3       
+    90% CI (Anderson-Hauck)                            (-21.6, -2.3)        (-23.0, -3.5)   
+  p-value (Fisher's Exact Test)                            0.0479               0.0253      
+Odds Ratio (90% CI)                                  0.57 (0.37 - 0.89)   0.54 (0.35 - 0.84)
+Complete Response (CR)                60 (44.8%)         47 (35.1%)           57 (43.2%)    
+  90% CI (Clopper-Pearson)          (37.48, 52.25)     (28.22, 42.43)       (35.88, 50.71)  
+Partial Response (PR)                 40 (29.9%)         37 (27.6%)           24 (18.2%)    
+  90% CI (Clopper-Pearson)          (23.36, 37.02)     (21.31, 34.67)       (12.87, 24.61)  
+Stable Disease (SD)                    9 (6.7%)          22 (16.4%)           13 (9.8%)     
+  90% CI (Clopper-Pearson)          (3.55, 11.43)      (11.38, 22.61)       (5.92, 15.20)   
+Progressive Disease (PD)              24 (17.9%)         16 (11.9%)           33 (25.0%)    
+  90% CI (Clopper-Pearson)          (12.67, 24.25)     (7.63, 17.57)        (18.90, 31.97)  
+Not Evaluable (NE)                     1 (0.7%)          12 (9.0%)             5 (3.8%)     
+  90% CI (Clopper-Pearson)           (0.04, 3.49)      (5.25, 14.11)         (1.50, 7.80)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>The stratified analysis section can be added by defining the analyses needed with <code>control_binary_comparison</code> for the argument <code>strat_analysis</code> and identifying the stratification variables to use.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant4_57ff10fcd81d0f7b153c1db27e292798">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>strata <span class="ot">&lt;-</span> <span class="st">"STRATA1"</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a>lyt_04 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb9-4"><a href="#cb9-4"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb9-5"><a href="#cb9-5"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-6"><a href="#cb9-6"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb9-7"><a href="#cb9-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-8"><a href="#cb9-8"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-10"><a href="#cb9-10"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb9-11"><a href="#cb9-11"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb9-12"><a href="#cb9-12"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb9-13"><a href="#cb9-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-14"><a href="#cb9-14"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb9-15"><a href="#cb9-15"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-16"><a href="#cb9-16"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb9-17"><a href="#cb9-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-18"><a href="#cb9-18"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb9-19"><a href="#cb9-19"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-20"><a href="#cb9-20"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb9-21"><a href="#cb9-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-22"><a href="#cb9-22"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb9-23"><a href="#cb9-23"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-24"><a href="#cb9-24"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb9-25"><a href="#cb9-25"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb9-26"><a href="#cb9-26"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb9-27"><a href="#cb9-27"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata),</span>
+<span id="cb9-28"><a href="#cb9-28"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb9-29"><a href="#cb9-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-30"><a href="#cb9-30"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb9-31"><a href="#cb9-31"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-32"><a href="#cb9-32"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb9-33"><a href="#cb9-33"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata),</span>
+<span id="cb9-34"><a href="#cb9-34"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb9-35"><a href="#cb9-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-36"><a href="#cb9-36"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb9-37"><a href="#cb9-37"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb9-38"><a href="#cb9-38"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb9-39"><a href="#cb9-39"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb9-40"><a href="#cb9-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb9-41"><a href="#cb9-41"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb9-42"><a href="#cb9-42"></a></span>
+<span id="cb9-43"><a href="#cb9-43"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_04, <span class="at">df =</span> anl)</span>
+<span id="cb9-44"><a href="#cb9-44"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                             A: Drug X          B: Placebo         C: Combination  
+                                              (N=134)            (N=134)              (N=132)      
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Responders                                  100 (74.6%)         84 (62.7%)           81 (61.4%)    
+95% CI (Wald, with correction)              (66.9, 82.4)       (54.1, 71.2)         (52.7, 70.0)   
+Unstratified Analysis                                                                              
+  Difference in Response rate (%)                                 -11.9                -13.3       
+    95% CI (Wald, with correction)                            (-23.7, -0.2)        (-25.1, -1.4)   
+  p-value (Chi-Squared Test)                                      0.0351               0.0204      
+Odds Ratio (95% CI)                                         0.57 (0.34 - 0.96)   0.54 (0.32 - 0.91)
+Stratified Analysis                                                                                
+  Difference in Response rate (%)                                 -11.9                -13.5       
+    95% CI (CMH, without correction)                          (-22.7, -1.0)        (-24.5, -2.5)   
+  p-value (Cochran-Mantel-Haenszel Test)                          0.0366               0.0180      
+Odds Ratio (95% CI)                                         0.57 (0.34 - 0.96)   0.54 (0.32 - 0.90)
+Complete Response (CR)                       60 (44.8%)         47 (35.1%)           57 (43.2%)    
+  95% CI (Wald, with correction)           (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  
+Partial Response (PR)                        40 (29.9%)         37 (27.6%)           24 (18.2%)    
+  95% CI (Wald, with correction)           (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  
+Stable Disease (SD)                           9 (6.7%)          22 (16.4%)           13 (9.8%)     
+  95% CI (Wald, with correction)           (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   
+Progressive Disease (PD)                     24 (17.9%)         16 (11.9%)           33 (25.0%)    
+  95% CI (Wald, with correction)           (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  
+Not Evaluable (NE)                            1 (0.7%)          12 (9.0%)             5 (3.8%)     
+  95% CI (Wald, with correction)            (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>The definition of <em>responders</em> is realized during the pre-processing step. The layout does not need to be modified and can be reused.</p>
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant5_804281377ef21ab22fe302694de4c0e7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">d_onco_rsp_label</span>(AVALC)) <span class="sc">%&gt;%</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb11-6"><a href="#cb11-6"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb11-9"><a href="#cb11-9"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X          B: Placebo         C: Combination  
+                                        (N=134)            (N=134)              (N=132)      
+—————————————————————————————————————————————————————————————————————————————————————————————
+Responders                             60 (44.8%)         47 (35.1%)           57 (43.2%)    
+95% CI (Wald, with correction)        (36.0, 53.6)       (26.6, 43.5)         (34.4, 52.0)   
+Unstratified Analysis                                                                        
+  Difference in Response rate (%)                            -9.7                 -1.6       
+    95% CI (Wald, with correction)                       (-22.1, 2.7)        (-14.3, 11.1)   
+  p-value (Chi-Squared Test)                                0.1049               0.7934      
+Odds Ratio (95% CI)                                   0.67 (0.41 - 1.09)   0.94 (0.58 - 1.52)
+Complete Response (CR)                 60 (44.8%)         47 (35.1%)           57 (43.2%)    
+  95% CI (Wald, with correction)     (35.98, 53.57)     (26.62, 43.53)       (34.35, 52.01)  
+Partial Response (PR)                  40 (29.9%)         37 (27.6%)           24 (18.2%)    
+  95% CI (Wald, with correction)     (21.73, 37.97)     (19.67, 35.55)       (11.22, 25.14)  
+Stable Disease (SD)                     9 (6.7%)          22 (16.4%)           13 (9.8%)     
+  95% CI (Wald, with correction)     (2.11, 11.33)      (9.77, 23.06)        (4.39, 15.31)   
+Progressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    
+  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  
+Not Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     
+  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<p>Similarly to in the previous tab, redefinition or relabeling of the result is a pre-processing step and the original table layout can be reused.</p>
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="rspt01_cache/html/variant6_17ac02ea5aaa4450c90d56fa27f827bd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-3"><a href="#cb13-3"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">as.character</span>(<span class="fu">d_onco_rsp_label</span>(AVALC))) <span class="sc">%&gt;%</span></span>
+<span id="cb13-4"><a href="#cb13-4"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb13-5"><a href="#cb13-5"></a>    <span class="at">rsp_lab =</span> <span class="fu">case_when</span>(</span>
+<span id="cb13-6"><a href="#cb13-6"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Complete Response (CR)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb13-7"><a href="#cb13-7"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Partial Response (PR)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb13-8"><a href="#cb13-8"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Stable Disease (SD)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb13-9"><a href="#cb13-9"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> rsp_lab</span>
+<span id="cb13-10"><a href="#cb13-10"></a>    )</span>
+<span id="cb13-11"><a href="#cb13-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-12"><a href="#cb13-12"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> rsp_lab <span class="sc">%in%</span> <span class="st">"No Progression"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-13"><a href="#cb13-13"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-14"><a href="#cb13-14"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span>
+<span id="cb13-15"><a href="#cb13-15"></a></span>
+<span id="cb13-16"><a href="#cb13-16"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb13-17"><a href="#cb13-17"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                       A: Drug X          B: Placebo         C: Combination  
+                                        (N=134)            (N=134)              (N=132)      
+—————————————————————————————————————————————————————————————————————————————————————————————
+Responders                            109 (81.3%)        106 (79.1%)           94 (71.2%)    
+95% CI (Wald, with correction)        (74.4, 88.3)       (71.8, 86.4)         (63.1, 79.3)   
+Unstratified Analysis                                                                        
+  Difference in Response rate (%)                            -2.2                -10.1       
+    95% CI (Wald, with correction)                       (-12.5, 8.0)         (-21.0, 0.8)   
+  p-value (Chi-Squared Test)                                0.6455               0.0520      
+Odds Ratio (95% CI)                                   0.87 (0.48 - 1.59)   0.57 (0.32 - 1.01)
+Progressive Disease (PD)               24 (17.9%)         16 (11.9%)           33 (25.0%)    
+  95% CI (Wald, with correction)     (11.05, 24.78)     (6.08, 17.80)        (17.23, 32.77)  
+No Progression                        109 (81.3%)        106 (79.1%)           94 (71.2%)    
+  95% CI (Wald, with correction)     (74.37, 88.31)     (71.85, 86.36)       (63.11, 79.31)  
+Not Evaluable (NE)                      1 (0.7%)          12 (9.0%)             5 (3.8%)     
+  95% CI (Wald, with correction)      (0.00, 2.58)      (3.75, 14.16)         (0.15, 7.42)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="rspt01_cache/html/teal_aa8c4aaf582cd845c718be61f03625b4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-4"><a href="#cb15-4"></a></span>
+<span id="cb15-5"><a href="#cb15-5"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-6"><a href="#cb15-6"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb15-9"><a href="#cb15-9"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADSL)</span>
+<span id="cb15-10"><a href="#cb15-10"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADRS)</span>
+<span id="cb15-11"><a href="#cb15-11"></a></span>
+<span id="cb15-12"><a href="#cb15-12"></a>ADSL <span class="ot">&lt;-</span> ADSL <span class="sc">%&gt;%</span></span>
+<span id="cb15-13"><a href="#cb15-13"></a>  <span class="fu">mutate</span>(<span class="at">Dum_ARM =</span> <span class="fu">factor</span>(<span class="fu">rep</span>(<span class="st">"Single ARM"</span>, <span class="fu">nrow</span>(.))))</span>
+<span id="cb15-14"><a href="#cb15-14"></a>ADRS <span class="ot">&lt;-</span> ADRS <span class="sc">%&gt;%</span></span>
+<span id="cb15-15"><a href="#cb15-15"></a>  <span class="fu">mutate</span>(<span class="at">Dum_ARM =</span> <span class="fu">factor</span>(<span class="fu">rep</span>(<span class="st">"Single ARM"</span>, <span class="fu">nrow</span>(.))))</span>
+<span id="cb15-16"><a href="#cb15-16"></a></span>
+<span id="cb15-17"><a href="#cb15-17"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb15-18"><a href="#cb15-18"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb15-19"><a href="#cb15-19"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb15-20"><a href="#cb15-20"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb15-21"><a href="#cb15-21"></a>  ),</span>
+<span id="cb15-22"><a href="#cb15-22"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb15-23"><a href="#cb15-23"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb15-24"><a href="#cb15-24"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb15-25"><a href="#cb15-25"></a>  )</span>
+<span id="cb15-26"><a href="#cb15-26"></a>)</span>
+<span id="cb15-27"><a href="#cb15-27"></a></span>
+<span id="cb15-28"><a href="#cb15-28"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb15-29"><a href="#cb15-29"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb15-30"><a href="#cb15-30"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb15-31"><a href="#cb15-31"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb15-32"><a href="#cb15-32"></a>      <span class="at">x =</span> ADSL,</span>
+<span id="cb15-33"><a href="#cb15-33"></a>      <span class="at">code =</span></span>
+<span id="cb15-34"><a href="#cb15-34"></a>        <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl")) %&gt;%</span></span>
+<span id="cb15-35"><a href="#cb15-35"></a><span class="st">           mutate(Dum_ARM = factor(rep("Single ARM", nrow(.))))'</span></span>
+<span id="cb15-36"><a href="#cb15-36"></a>    ),</span>
+<span id="cb15-37"><a href="#cb15-37"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb15-38"><a href="#cb15-38"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb15-39"><a href="#cb15-39"></a>      <span class="at">x =</span> ADRS,</span>
+<span id="cb15-40"><a href="#cb15-40"></a>      <span class="at">code =</span></span>
+<span id="cb15-41"><a href="#cb15-41"></a>        <span class="st">'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adrs")) %&gt;%</span></span>
+<span id="cb15-42"><a href="#cb15-42"></a><span class="st">          mutate(Dum_ARM = factor(rep("Single ARM", nrow(.))))'</span></span>
+<span id="cb15-43"><a href="#cb15-43"></a>    ),</span>
+<span id="cb15-44"><a href="#cb15-44"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-45"><a href="#cb15-45"></a>  ),</span>
+<span id="cb15-46"><a href="#cb15-46"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb15-47"><a href="#cb15-47"></a>    <span class="fu">tm_t_binary_outcome</span>(</span>
+<span id="cb15-48"><a href="#cb15-48"></a>      <span class="at">label =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb15-49"><a href="#cb15-49"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb15-50"><a href="#cb15-50"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-51"><a href="#cb15-51"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb15-52"><a href="#cb15-52"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb15-53"><a href="#cb15-53"></a>      ),</span>
+<span id="cb15-54"><a href="#cb15-54"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-55"><a href="#cb15-55"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"Dum_ARM"</span>)),</span>
+<span id="cb15-56"><a href="#cb15-56"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb15-57"><a href="#cb15-57"></a>      ),</span>
+<span id="cb15-58"><a href="#cb15-58"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb15-59"><a href="#cb15-59"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb15-60"><a href="#cb15-60"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb15-61"><a href="#cb15-61"></a>        <span class="at">select =</span> <span class="cn">NULL</span></span>
+<span id="cb15-62"><a href="#cb15-62"></a>      ),</span>
+<span id="cb15-63"><a href="#cb15-63"></a>      <span class="at">rsp_table =</span> <span class="cn">TRUE</span></span>
+<span id="cb15-64"><a href="#cb15-64"></a>    )</span>
+<span id="cb15-65"><a href="#cb15-65"></a>  )</span>
+<span id="cb15-66"><a href="#cb15-66"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:56:25.5008 pid:7162 token:[] teal.modules.clinical Initializing tm_t_binary_outcome</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="rspt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rspt01_cache/html/sessioninfo_83077fba17cac7268646d5908ba59d68">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb18"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb18-1"><a href="#cb18-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rspt01_cache/html/snapshot_ead7cde291fef110a32f2f06a2bc8c4a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb20"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb20-1"><a href="#cb20-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb20-2"><a href="#cb20-2"></a></span>
+<span id="cb20-3"><a href="#cb20-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb20-4"><a href="#cb20-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb20-5"><a href="#cb20-5"></a></span>
+<span id="cb20-6"><a href="#cb20-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb20-7"><a href="#cb20-7"></a></span>
+<span id="cb20-8"><a href="#cb20-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb20-9"><a href="#cb20-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb20-10"><a href="#cb20-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb20-11"><a href="#cb20-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/rspt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+<div class="sourceCode" id="cb21" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb21-1"><a href="#cb21-1"></a><span class="co">---</span></span>
+<span id="cb21-2"><a href="#cb21-2"></a><span class="an">title:</span><span class="co"> RSPT01</span></span>
+<span id="cb21-3"><a href="#cb21-3"></a><span class="an">subtitle:</span><span class="co"> Best Overall Response</span></span>
+<span id="cb21-4"><a href="#cb21-4"></a><span class="co">---</span></span>
+<span id="cb21-5"><a href="#cb21-5"></a></span>
+<span id="cb21-6"><a href="#cb21-6"></a>------------------------------------------------------------------------</span>
+<span id="cb21-7"><a href="#cb21-7"></a></span>
+<span id="cb21-8"><a href="#cb21-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb21-9"><a href="#cb21-9"></a></span>
+<span id="cb21-10"><a href="#cb21-10"></a>::: panel-tabset</span>
+<span id="cb21-11"><a href="#cb21-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb21-12"><a href="#cb21-12"></a></span>
+<span id="cb21-13"><a href="#cb21-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb21-14"><a href="#cb21-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb21-15"><a href="#cb21-15"></a></span>
+<span id="cb21-16"><a href="#cb21-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb21-17"><a href="#cb21-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb21-18"><a href="#cb21-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb21-19"><a href="#cb21-19"></a></span>
+<span id="cb21-20"><a href="#cb21-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb21-21"><a href="#cb21-21"></a>adrs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb21-22"><a href="#cb21-22"></a></span>
+<span id="cb21-23"><a href="#cb21-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb21-24"><a href="#cb21-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb21-25"><a href="#cb21-25"></a>adrs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adrs)</span>
+<span id="cb21-26"><a href="#cb21-26"></a></span>
+<span id="cb21-27"><a href="#cb21-27"></a>anl_adrs <span class="ot">&lt;-</span> adrs <span class="sc">%&gt;%</span></span>
+<span id="cb21-28"><a href="#cb21-28"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"INVET"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-29"><a href="#cb21-29"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVISIT, AVALC)</span>
+<span id="cb21-30"><a href="#cb21-30"></a>anl_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb21-31"><a href="#cb21-31"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ARM, STRATA1)</span>
+<span id="cb21-32"><a href="#cb21-32"></a><span class="in">```</span></span>
+<span id="cb21-33"><a href="#cb21-33"></a></span>
+<span id="cb21-34"><a href="#cb21-34"></a>Data pre-processing is done to label the analysis value (<span class="in">`AVALC`</span>) so as to improve the readability of the output table.</span>
+<span id="cb21-35"><a href="#cb21-35"></a>In addition, the *response* is binary defined (<span class="in">`is_rsp`</span>, responder yes/no) depending on the analysis value.</span>
+<span id="cb21-36"><a href="#cb21-36"></a>Finally, for comparison purposes, the reference arm is specified.</span>
+<span id="cb21-37"><a href="#cb21-37"></a></span>
+<span id="cb21-40"><a href="#cb21-40"></a><span class="in">```{r}</span></span>
+<span id="cb21-41"><a href="#cb21-41"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb21-42"><a href="#cb21-42"></a></span>
+<span id="cb21-43"><a href="#cb21-43"></a><span class="co"># Pre-Processing</span></span>
+<span id="cb21-44"><a href="#cb21-44"></a></span>
+<span id="cb21-45"><a href="#cb21-45"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb21-46"><a href="#cb21-46"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-47"><a href="#cb21-47"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">d_onco_rsp_label</span>(AVALC)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-48"><a href="#cb21-48"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"CR"</span>, <span class="st">"PR"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-49"><a href="#cb21-49"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-50"><a href="#cb21-50"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span>
+<span id="cb21-51"><a href="#cb21-51"></a><span class="in">```</span></span>
+<span id="cb21-52"><a href="#cb21-52"></a></span>
+<span id="cb21-53"><a href="#cb21-53"></a><span class="fu">## Standard Table</span></span>
+<span id="cb21-54"><a href="#cb21-54"></a></span>
+<span id="cb21-55"><a href="#cb21-55"></a>The tabulation layout is built in layers for the analysis of overall response and applied to the pre-processed dataset.</span>
+<span id="cb21-56"><a href="#cb21-56"></a></span>
+<span id="cb21-57"><a href="#cb21-57"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb21-58"><a href="#cb21-58"></a>lyt_01 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-59"><a href="#cb21-59"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-60"><a href="#cb21-60"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb21-61"><a href="#cb21-61"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-62"><a href="#cb21-62"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb21-63"><a href="#cb21-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-64"><a href="#cb21-64"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb21-65"><a href="#cb21-65"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-66"><a href="#cb21-66"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-67"><a href="#cb21-67"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb21-68"><a href="#cb21-68"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb21-69"><a href="#cb21-69"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-70"><a href="#cb21-70"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb21-71"><a href="#cb21-71"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-72"><a href="#cb21-72"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_diff"</span></span>
+<span id="cb21-73"><a href="#cb21-73"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-74"><a href="#cb21-74"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb21-75"><a href="#cb21-75"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-76"><a href="#cb21-76"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb21-77"><a href="#cb21-77"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-78"><a href="#cb21-78"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb21-79"><a href="#cb21-79"></a></span>
+<span id="cb21-80"><a href="#cb21-80"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb21-81"><a href="#cb21-81"></a>result</span>
+<span id="cb21-82"><a href="#cb21-82"></a><span class="in">```</span></span>
+<span id="cb21-83"><a href="#cb21-83"></a></span>
+<span id="cb21-84"><a href="#cb21-84"></a><span class="fu">## Table Selecting &lt;br/&gt; Sections to Display</span></span>
+<span id="cb21-85"><a href="#cb21-85"></a></span>
+<span id="cb21-86"><a href="#cb21-86"></a>Remove (or add) rows of results by removing/adding the corresponding layers from the layout.</span>
+<span id="cb21-87"><a href="#cb21-87"></a>For instance, the odds-ratio row is removed by simply removing the <span class="in">`estimate_odds_ratio`</span> call:</span>
+<span id="cb21-88"><a href="#cb21-88"></a></span>
+<span id="cb21-89"><a href="#cb21-89"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb21-90"><a href="#cb21-90"></a>lyt_02 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-91"><a href="#cb21-91"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-92"><a href="#cb21-92"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb21-93"><a href="#cb21-93"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-94"><a href="#cb21-94"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb21-95"><a href="#cb21-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-96"><a href="#cb21-96"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb21-97"><a href="#cb21-97"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-98"><a href="#cb21-98"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-99"><a href="#cb21-99"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb21-100"><a href="#cb21-100"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb21-101"><a href="#cb21-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-102"><a href="#cb21-102"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb21-103"><a href="#cb21-103"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-104"><a href="#cb21-104"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb21-105"><a href="#cb21-105"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-106"><a href="#cb21-106"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb21-107"><a href="#cb21-107"></a></span>
+<span id="cb21-108"><a href="#cb21-108"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_02, <span class="at">df =</span> anl)</span>
+<span id="cb21-109"><a href="#cb21-109"></a>result</span>
+<span id="cb21-110"><a href="#cb21-110"></a><span class="in">```</span></span>
+<span id="cb21-111"><a href="#cb21-111"></a></span>
+<span id="cb21-112"><a href="#cb21-112"></a><span class="fu">## Table Modifying Analysis Details like Type of &lt;br/&gt; Confidence Interval, Alpha Level, Test Statistic</span></span>
+<span id="cb21-113"><a href="#cb21-113"></a></span>
+<span id="cb21-114"><a href="#cb21-114"></a>The confidence level is controlled by the <span class="in">`conf_level`</span> parameter to the estimation functions.</span>
+<span id="cb21-115"><a href="#cb21-115"></a>Similarly, the methods for tests and confidence interval can be modified (see <span class="in">`?estimate_proportion_diff`</span>).</span>
+<span id="cb21-116"><a href="#cb21-116"></a></span>
+<span id="cb21-117"><a href="#cb21-117"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb21-118"><a href="#cb21-118"></a>conf_level <span class="ot">&lt;-</span> <span class="fl">0.90</span></span>
+<span id="cb21-119"><a href="#cb21-119"></a>lyt_03 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-120"><a href="#cb21-120"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-121"><a href="#cb21-121"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb21-122"><a href="#cb21-122"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-123"><a href="#cb21-123"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb21-124"><a href="#cb21-124"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb21-125"><a href="#cb21-125"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb21-126"><a href="#cb21-126"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-127"><a href="#cb21-127"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb21-128"><a href="#cb21-128"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-129"><a href="#cb21-129"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-130"><a href="#cb21-130"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb21-131"><a href="#cb21-131"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb21-132"><a href="#cb21-132"></a>    <span class="at">method =</span> <span class="st">"ha"</span>,</span>
+<span id="cb21-133"><a href="#cb21-133"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb21-134"><a href="#cb21-134"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-135"><a href="#cb21-135"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb21-136"><a href="#cb21-136"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-137"><a href="#cb21-137"></a>    <span class="at">method =</span> <span class="st">"fisher"</span>,</span>
+<span id="cb21-138"><a href="#cb21-138"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb21-139"><a href="#cb21-139"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-140"><a href="#cb21-140"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb21-141"><a href="#cb21-141"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-142"><a href="#cb21-142"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb21-143"><a href="#cb21-143"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb21-144"><a href="#cb21-144"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-145"><a href="#cb21-145"></a>  <span class="fu">estimate_multinomial_response</span>(</span>
+<span id="cb21-146"><a href="#cb21-146"></a>    <span class="at">var =</span> <span class="st">"rsp_lab"</span>,</span>
+<span id="cb21-147"><a href="#cb21-147"></a>    <span class="at">conf_level =</span> conf_level,</span>
+<span id="cb21-148"><a href="#cb21-148"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span></span>
+<span id="cb21-149"><a href="#cb21-149"></a>  )</span>
+<span id="cb21-150"><a href="#cb21-150"></a></span>
+<span id="cb21-151"><a href="#cb21-151"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_03, <span class="at">df =</span> anl)</span>
+<span id="cb21-152"><a href="#cb21-152"></a>result</span>
+<span id="cb21-153"><a href="#cb21-153"></a><span class="in">```</span></span>
+<span id="cb21-154"><a href="#cb21-154"></a></span>
+<span id="cb21-155"><a href="#cb21-155"></a><span class="fu">## Table with &lt;br/&gt; Stratified Analysis</span></span>
+<span id="cb21-156"><a href="#cb21-156"></a></span>
+<span id="cb21-157"><a href="#cb21-157"></a>The stratified analysis section can be added by defining the analyses needed with <span class="in">`control_binary_comparison`</span> for the argument <span class="in">`strat_analysis`</span> and identifying the stratification variables to use.</span>
+<span id="cb21-158"><a href="#cb21-158"></a></span>
+<span id="cb21-159"><a href="#cb21-159"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb21-160"><a href="#cb21-160"></a>strata <span class="ot">&lt;-</span> <span class="st">"STRATA1"</span></span>
+<span id="cb21-161"><a href="#cb21-161"></a>lyt_04 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-162"><a href="#cb21-162"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-163"><a href="#cb21-163"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb21-164"><a href="#cb21-164"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-165"><a href="#cb21-165"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb21-166"><a href="#cb21-166"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-167"><a href="#cb21-167"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb21-168"><a href="#cb21-168"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-169"><a href="#cb21-169"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-170"><a href="#cb21-170"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb21-171"><a href="#cb21-171"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb21-172"><a href="#cb21-172"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-173"><a href="#cb21-173"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb21-174"><a href="#cb21-174"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-175"><a href="#cb21-175"></a>    <span class="at">table_names =</span> <span class="st">"test_prop"</span></span>
+<span id="cb21-176"><a href="#cb21-176"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-177"><a href="#cb21-177"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb21-178"><a href="#cb21-178"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-179"><a href="#cb21-179"></a>    <span class="at">table_names =</span> <span class="st">"est_or"</span></span>
+<span id="cb21-180"><a href="#cb21-180"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-181"><a href="#cb21-181"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb21-182"><a href="#cb21-182"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-183"><a href="#cb21-183"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb21-184"><a href="#cb21-184"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb21-185"><a href="#cb21-185"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb21-186"><a href="#cb21-186"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata),</span>
+<span id="cb21-187"><a href="#cb21-187"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff_strat"</span></span>
+<span id="cb21-188"><a href="#cb21-188"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-189"><a href="#cb21-189"></a>  <span class="fu">test_proportion_diff</span>(</span>
+<span id="cb21-190"><a href="#cb21-190"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-191"><a href="#cb21-191"></a>    <span class="at">method =</span> <span class="st">"cmh"</span>,</span>
+<span id="cb21-192"><a href="#cb21-192"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata),</span>
+<span id="cb21-193"><a href="#cb21-193"></a>    <span class="at">table_names =</span> <span class="st">"test_prop_strat"</span></span>
+<span id="cb21-194"><a href="#cb21-194"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-195"><a href="#cb21-195"></a>  <span class="fu">estimate_odds_ratio</span>(</span>
+<span id="cb21-196"><a href="#cb21-196"></a>    <span class="at">vars =</span> <span class="st">"is_rsp"</span>,</span>
+<span id="cb21-197"><a href="#cb21-197"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">strata =</span> strata, <span class="at">arm =</span> <span class="st">"ARM"</span>),</span>
+<span id="cb21-198"><a href="#cb21-198"></a>    <span class="at">table_names =</span> <span class="st">"est_or_strat"</span></span>
+<span id="cb21-199"><a href="#cb21-199"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-200"><a href="#cb21-200"></a>  <span class="fu">estimate_multinomial_response</span>(<span class="at">var =</span> <span class="st">"rsp_lab"</span>)</span>
+<span id="cb21-201"><a href="#cb21-201"></a></span>
+<span id="cb21-202"><a href="#cb21-202"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_04, <span class="at">df =</span> anl)</span>
+<span id="cb21-203"><a href="#cb21-203"></a>result</span>
+<span id="cb21-204"><a href="#cb21-204"></a><span class="in">```</span></span>
+<span id="cb21-205"><a href="#cb21-205"></a></span>
+<span id="cb21-206"><a href="#cb21-206"></a><span class="fu">## Table Modifying the Definition &lt;br/&gt; of Overall Response</span></span>
+<span id="cb21-207"><a href="#cb21-207"></a></span>
+<span id="cb21-208"><a href="#cb21-208"></a>The definition of *responders* is realized during the pre-processing step.</span>
+<span id="cb21-209"><a href="#cb21-209"></a>The layout does not need to be modified and can be reused.</span>
+<span id="cb21-210"><a href="#cb21-210"></a></span>
+<span id="cb21-211"><a href="#cb21-211"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb21-212"><a href="#cb21-212"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb21-213"><a href="#cb21-213"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-214"><a href="#cb21-214"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">d_onco_rsp_label</span>(AVALC)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-215"><a href="#cb21-215"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> AVALC <span class="sc">==</span> <span class="st">"CR"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-216"><a href="#cb21-216"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-217"><a href="#cb21-217"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span>
+<span id="cb21-218"><a href="#cb21-218"></a></span>
+<span id="cb21-219"><a href="#cb21-219"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb21-220"><a href="#cb21-220"></a>result</span>
+<span id="cb21-221"><a href="#cb21-221"></a><span class="in">```</span></span>
+<span id="cb21-222"><a href="#cb21-222"></a></span>
+<span id="cb21-223"><a href="#cb21-223"></a><span class="fu">## Table Defining New &lt;br/&gt; Sections to Display</span></span>
+<span id="cb21-224"><a href="#cb21-224"></a></span>
+<span id="cb21-225"><a href="#cb21-225"></a>Similarly to in the previous tab, redefinition or relabeling of the result is a pre-processing step and the original table layout can be reused.</span>
+<span id="cb21-226"><a href="#cb21-226"></a></span>
+<span id="cb21-227"><a href="#cb21-227"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb21-228"><a href="#cb21-228"></a>anl <span class="ot">&lt;-</span> anl_adsl <span class="sc">%&gt;%</span></span>
+<span id="cb21-229"><a href="#cb21-229"></a>  <span class="fu">left_join</span>(anl_adrs, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-230"><a href="#cb21-230"></a>  <span class="fu">mutate</span>(<span class="at">rsp_lab =</span> <span class="fu">as.character</span>(<span class="fu">d_onco_rsp_label</span>(AVALC))) <span class="sc">%&gt;%</span></span>
+<span id="cb21-231"><a href="#cb21-231"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb21-232"><a href="#cb21-232"></a>    <span class="at">rsp_lab =</span> <span class="fu">case_when</span>(</span>
+<span id="cb21-233"><a href="#cb21-233"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Complete Response (CR)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb21-234"><a href="#cb21-234"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Partial Response (PR)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb21-235"><a href="#cb21-235"></a>      rsp_lab <span class="sc">==</span> <span class="st">"Stable Disease (SD)"</span> <span class="sc">~</span> <span class="st">"No Progression"</span>,</span>
+<span id="cb21-236"><a href="#cb21-236"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> rsp_lab</span>
+<span id="cb21-237"><a href="#cb21-237"></a>    )</span>
+<span id="cb21-238"><a href="#cb21-238"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb21-239"><a href="#cb21-239"></a>  <span class="fu">mutate</span>(<span class="at">is_rsp =</span> rsp_lab <span class="sc">%in%</span> <span class="st">"No Progression"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb21-240"><a href="#cb21-240"></a>  <span class="fu">mutate</span>(<span class="at">ARM =</span> <span class="fu">relevel</span>(ARM, <span class="at">ref =</span> <span class="st">"A: Drug X"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb21-241"><a href="#cb21-241"></a>  <span class="fu">var_relabel</span>(<span class="at">ARM =</span> <span class="st">"Description of Planned Arm"</span>)</span>
+<span id="cb21-242"><a href="#cb21-242"></a></span>
+<span id="cb21-243"><a href="#cb21-243"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt_01, <span class="at">df =</span> anl)</span>
+<span id="cb21-244"><a href="#cb21-244"></a>result</span>
+<span id="cb21-245"><a href="#cb21-245"></a><span class="in">```</span></span>
+<span id="cb21-246"><a href="#cb21-246"></a></span>
+<span id="cb21-247"><a href="#cb21-247"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb21-248"><a href="#cb21-248"></a></span>
+<span id="cb21-249"><a href="#cb21-249"></a><span class="fu">## `teal` App</span></span>
+<span id="cb21-250"><a href="#cb21-250"></a></span>
+<span id="cb21-251"><a href="#cb21-251"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb21-252"><a href="#cb21-252"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb21-253"><a href="#cb21-253"></a></span>
+<span id="cb21-254"><a href="#cb21-254"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb21-255"><a href="#cb21-255"></a><span class="fu">library</span>(scda)</span>
+<span id="cb21-256"><a href="#cb21-256"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb21-257"><a href="#cb21-257"></a></span>
+<span id="cb21-258"><a href="#cb21-258"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb21-259"><a href="#cb21-259"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adrs"</span>)</span>
+<span id="cb21-260"><a href="#cb21-260"></a></span>
+<span id="cb21-261"><a href="#cb21-261"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb21-262"><a href="#cb21-262"></a>ADSL <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADSL)</span>
+<span id="cb21-263"><a href="#cb21-263"></a>ADRS <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(ADRS)</span>
+<span id="cb21-264"><a href="#cb21-264"></a></span>
+<span id="cb21-265"><a href="#cb21-265"></a>ADSL <span class="ot">&lt;-</span> ADSL <span class="sc">%&gt;%</span></span>
+<span id="cb21-266"><a href="#cb21-266"></a>  <span class="fu">mutate</span>(<span class="at">Dum_ARM =</span> <span class="fu">factor</span>(<span class="fu">rep</span>(<span class="st">"Single ARM"</span>, <span class="fu">nrow</span>(.))))</span>
+<span id="cb21-267"><a href="#cb21-267"></a>ADRS <span class="ot">&lt;-</span> ADRS <span class="sc">%&gt;%</span></span>
+<span id="cb21-268"><a href="#cb21-268"></a>  <span class="fu">mutate</span>(<span class="at">Dum_ARM =</span> <span class="fu">factor</span>(<span class="fu">rep</span>(<span class="st">"Single ARM"</span>, <span class="fu">nrow</span>(.))))</span>
+<span id="cb21-269"><a href="#cb21-269"></a></span>
+<span id="cb21-270"><a href="#cb21-270"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb21-271"><a href="#cb21-271"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb21-272"><a href="#cb21-272"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb21-273"><a href="#cb21-273"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb21-274"><a href="#cb21-274"></a>  ),</span>
+<span id="cb21-275"><a href="#cb21-275"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb21-276"><a href="#cb21-276"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb21-277"><a href="#cb21-277"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb21-278"><a href="#cb21-278"></a>  )</span>
+<span id="cb21-279"><a href="#cb21-279"></a>)</span>
+<span id="cb21-280"><a href="#cb21-280"></a></span>
+<span id="cb21-281"><a href="#cb21-281"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb21-282"><a href="#cb21-282"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb21-283"><a href="#cb21-283"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb21-284"><a href="#cb21-284"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb21-285"><a href="#cb21-285"></a>      <span class="at">x =</span> ADSL,</span>
+<span id="cb21-286"><a href="#cb21-286"></a>      <span class="at">code =</span></span>
+<span id="cb21-287"><a href="#cb21-287"></a>        <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl")) %&gt;%</span></span>
+<span id="cb21-288"><a href="#cb21-288"></a><span class="st">           mutate(Dum_ARM = factor(rep("Single ARM", nrow(.))))'</span></span>
+<span id="cb21-289"><a href="#cb21-289"></a>    ),</span>
+<span id="cb21-290"><a href="#cb21-290"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb21-291"><a href="#cb21-291"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb21-292"><a href="#cb21-292"></a>      <span class="at">x =</span> ADRS,</span>
+<span id="cb21-293"><a href="#cb21-293"></a>      <span class="at">code =</span></span>
+<span id="cb21-294"><a href="#cb21-294"></a>        <span class="st">'ADRS &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adrs")) %&gt;%</span></span>
+<span id="cb21-295"><a href="#cb21-295"></a><span class="st">          mutate(Dum_ARM = factor(rep("Single ARM", nrow(.))))'</span></span>
+<span id="cb21-296"><a href="#cb21-296"></a>    ),</span>
+<span id="cb21-297"><a href="#cb21-297"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb21-298"><a href="#cb21-298"></a>  ),</span>
+<span id="cb21-299"><a href="#cb21-299"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb21-300"><a href="#cb21-300"></a>    <span class="fu">tm_t_binary_outcome</span>(</span>
+<span id="cb21-301"><a href="#cb21-301"></a>      <span class="at">label =</span> <span class="st">"Responders"</span>,</span>
+<span id="cb21-302"><a href="#cb21-302"></a>      <span class="at">dataname =</span> <span class="st">"ADRS"</span>,</span>
+<span id="cb21-303"><a href="#cb21-303"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-304"><a href="#cb21-304"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(ADRS, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb21-305"><a href="#cb21-305"></a>        <span class="at">selected =</span> <span class="st">"BESRSPI"</span></span>
+<span id="cb21-306"><a href="#cb21-306"></a>      ),</span>
+<span id="cb21-307"><a href="#cb21-307"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-308"><a href="#cb21-308"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>, <span class="st">"Dum_ARM"</span>)),</span>
+<span id="cb21-309"><a href="#cb21-309"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb21-310"><a href="#cb21-310"></a>      ),</span>
+<span id="cb21-311"><a href="#cb21-311"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb21-312"><a href="#cb21-312"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb21-313"><a href="#cb21-313"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(ADRS, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb21-314"><a href="#cb21-314"></a>        <span class="at">select =</span> <span class="cn">NULL</span></span>
+<span id="cb21-315"><a href="#cb21-315"></a>      ),</span>
+<span id="cb21-316"><a href="#cb21-316"></a>      <span class="at">rsp_table =</span> <span class="cn">TRUE</span></span>
+<span id="cb21-317"><a href="#cb21-317"></a>    )</span>
+<span id="cb21-318"><a href="#cb21-318"></a>  )</span>
+<span id="cb21-319"><a href="#cb21-319"></a>)</span>
+<span id="cb21-320"><a href="#cb21-320"></a></span>
+<span id="cb21-321"><a href="#cb21-321"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb21-322"><a href="#cb21-322"></a><span class="in">```</span></span>
+<span id="cb21-323"><a href="#cb21-323"></a></span>
+<span id="cb21-324"><a href="#cb21-324"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb21-325"><a href="#cb21-325"></a></span>
+<span id="cb21-326"><a href="#cb21-326"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+  </div>
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+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+</li>
+      </ul>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">Deaths</span></a>
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Disclosures</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+</li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="true">
+ <span class="menu-text">Efficacy</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">TTET01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Time-To-Event Summary</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Modifying Analysis Details <br> like Conf. Type, Ties, Alpha Level</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with <br> Stratified Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table Modifying Time Point for <br> the “XX Months” Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Table Requesting <br> &gt; 1 p-value</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-9-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-9" role="tab" aria-controls="tabset-1-9" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ttet01_cache/html/setup_0a185177763aa3bec2d244797e37202c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure that character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adtte_f <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">is_not_event =</span> CNSR <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">EVNT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>        is_event <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Patients with event (%)"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>        is_event <span class="sc">==</span> <span class="cn">FALSE</span> <span class="sc">~</span> <span class="st">"Patients without event (%)"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>      ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Patients with event (%)"</span>, <span class="st">"Patients without event (%)"</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    ),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">EVNTDESC =</span> <span class="fu">factor</span>(EVNTDESC)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant1_473c8053749a35df524bcc22b05e1b79">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-3"><a href="#cb2-3"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb2-38"><a href="#cb2-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb2-42"><a href="#cb2-42"></a>    <span class="at">time_point =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">12</span>),</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">method =</span> <span class="st">"both"</span>,</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>()</span>
+<span id="cb2-46"><a href="#cb2-46"></a>  )</span>
+<span id="cb2-47"><a href="#cb2-47"></a></span>
+<span id="cb2-48"><a href="#cb2-48"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-49"><a href="#cb2-49"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-50"><a href="#cb2-50"></a></span>
+<span id="cb2-51"><a href="#cb2-51"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X        B: Placebo      C: Combination
+                                     (N=134)           (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Patients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  
+  Earliest contributing event                                                      
+    Death                               58               58                69      
+Patients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  
+Time to Event (Months)                                                             
+  Median                                NA               NA               9.4      
+    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   
+  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    
+  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  
+  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  
+Unstratified Analysis                                                              
+  p-value (log-rank)                                   0.9998            0.1541    
+  Hazard Ratio                                          1.00              1.29     
+  95% CI                                            (0.69, 1.44)      (0.91, 1.83) 
+6 Months                                                                           
+  Patients remaining at risk            97               97                90      
+  Event Free Rate (%)                 72.39             72.39            68.18     
+  95% CI                          (64.82, 79.96)   (64.82, 79.96)    (60.24, 76.13)
+  Difference in Event Free Rate                         0.00             -4.21     
+    95% CI                                         (-10.71, 10.71)   (-15.18, 6.77)
+    p-value (Z-test)                                   1.0000            0.4525    
+12 Months                                                                          
+  Patients remaining at risk            49               48                37      
+  Event Free Rate (%)                 56.72             56.72            47.73     
+  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)
+  Difference in Event Free Rate                         0.00             -8.99     
+    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)
+    p-value (Z-test)                                   1.0000            0.1406    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant2_9415981fd2bdae8945d20ee758923080">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="st">"is_not_event"</span>,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-30"><a href="#cb4-30"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">method =</span> <span class="st">"surv"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">time_point =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">12</span>)</span>
+<span id="cb4-34"><a href="#cb4-34"></a>  )</span>
+<span id="cb4-35"><a href="#cb4-35"></a></span>
+<span id="cb4-36"><a href="#cb4-36"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-37"><a href="#cb4-37"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                 A: Drug X        B: Placebo     C: Combination
+                                  (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————
+Patients with event (%)          58 (43.3%)       58 (43.3%)       69 (52.3%)  
+Patients without event (%)       76 (56.7%)       76 (56.7%)       63 (47.7%)  
+Time to Event (Months)                                                         
+  Median                             NA               NA              9.4      
+    95% CI                       (9.3, NA)        (9.4, NA)        (7.6, NA)   
+  25% and 75%-ile                 5.6, NA          5.6, NA          5.0, NA    
+  Range (censored)              9.9 to 16.4      9.9 to 16.3      9.9 to 16.3  
+  Range (event)                  0.5 to 9.6       0.9 to 9.6       0.5 to 9.8  
+Unstratified Analysis                                                          
+  p-value (log-rank)                                0.9998           0.1541    
+  Hazard Ratio                                       1.00             1.29     
+  95% CI                                         (0.69, 1.44)     (0.91, 1.83) 
+6 Months                                                                       
+  Patients remaining at risk         97               97               90      
+  Event Free Rate (%)              72.39            72.39            68.18     
+  95% CI                       (64.82, 79.96)   (64.82, 79.96)   (60.24, 76.13)
+12 Months                                                                      
+  Patients remaining at risk         49               48               37      
+  Event Free Rate (%)              56.72            56.72            47.73     
+  95% CI                       (48.33, 65.11)   (48.33, 65.11)   (39.21, 56.25)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant3_deaedf7fcb57c665a11e8e6c604288ae">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">control =</span> <span class="fu">control_surv_time</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>      <span class="at">pval_method =</span> <span class="st">"log-rank"</span>,</span>
+<span id="cb6-37"><a href="#cb6-37"></a>      <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb6-38"><a href="#cb6-38"></a>      <span class="at">ties =</span> <span class="st">"efron"</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>    ),</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>),</span>
+<span id="cb6-48"><a href="#cb6-48"></a>    <span class="at">table_names_suffix =</span> <span class="st">"_log_log"</span></span>
+<span id="cb6-49"><a href="#cb6-49"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb6-51"><a href="#cb6-51"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-52"><a href="#cb6-52"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb6-53"><a href="#cb6-53"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-54"><a href="#cb6-54"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb6-55"><a href="#cb6-55"></a>    <span class="at">method =</span> <span class="st">"surv_diff"</span>,</span>
+<span id="cb6-56"><a href="#cb6-56"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.975</span>),</span>
+<span id="cb6-57"><a href="#cb6-57"></a>    <span class="at">table_names_suffix =</span> <span class="st">"_975_pct"</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a>  )</span>
+<span id="cb6-59"><a href="#cb6-59"></a></span>
+<span id="cb6-60"><a href="#cb6-60"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-61"><a href="#cb6-61"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb6-62"><a href="#cb6-62"></a></span>
+<span id="cb6-63"><a href="#cb6-63"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                  A: Drug X        B: Placebo      C: Combination
+                                   (N=134)           (N=134)          (N=132)    
+—————————————————————————————————————————————————————————————————————————————————
+Patients with event (%)           58 (43.3%)       58 (43.3%)        69 (52.3%)  
+  Earliest contributing event                                                    
+    Death                             58               58                69      
+Patients without event (%)        76 (56.7%)       76 (56.7%)        63 (47.7%)  
+Time to Event (Months)                                                           
+  Median                              NA               NA               9.4      
+    90% CI                        (9.6, NA)         (9.6, NA)        (7.7, NA)   
+  25% and 75%-ile                  5.6, NA           5.6, NA          5.0, NA    
+  Range (censored)               9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  
+  Range (event)                   0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  
+Unstratified Analysis                                                            
+  p-value (log-rank)                                 0.9998            0.1541    
+  Hazard Ratio                                        1.00              1.29     
+  95% CI                                          (0.69, 1.44)      (0.91, 1.83) 
+12 Months                                                                        
+  Patients remaining at risk          49               48                37      
+  Event Free Rate (%)               56.72             56.72            47.73     
+  90% CI                        (49.37, 63.41)   (49.37, 63.41)    (40.42, 54.66)
+Difference in Event Free Rate                         0.00             -8.99     
+  97.5% CI                                       (-13.57, 13.57)   (-22.66, 4.69)
+  p-value (Z-test)                                   1.0000            0.1406    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant4_5d0891a6b26cd82f3f1481b5d10a161c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb8-7"><a href="#cb8-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb8-10"><a href="#cb8-10"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-17"><a href="#cb8-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-26"><a href="#cb8-26"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-33"><a href="#cb8-33"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">strat =</span> <span class="st">"SEX"</span>,</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">method =</span> <span class="st">"both"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">time_point =</span> <span class="dv">12</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>  )</span>
+<span id="cb8-50"><a href="#cb8-50"></a></span>
+<span id="cb8-51"><a href="#cb8-51"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb8-53"><a href="#cb8-53"></a></span>
+<span id="cb8-54"><a href="#cb8-54"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X        B: Placebo      C: Combination
+                                     (N=134)           (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Patients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  
+  Earliest contributing event                                                      
+    Death                               58               58                69      
+Patients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  
+Time to Event (Months)                                                             
+  Median                                NA               NA               9.4      
+    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   
+  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    
+  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  
+  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  
+Unstratified Analysis                                                              
+  p-value (log-rank)                                   0.9998            0.1541    
+  Hazard Ratio                                          1.00              1.29     
+  95% CI                                            (0.69, 1.44)      (0.91, 1.83) 
+Stratified Analysis                                                                
+  p-value (log-rank)                                   0.9978            0.1733    
+  Hazard Ratio                                          1.00              1.27     
+  95% CI                                            (0.69, 1.44)      (0.90, 1.81) 
+12 Months                                                                          
+  Patients remaining at risk            49               48                37      
+  Event Free Rate (%)                 56.72             56.72            47.73     
+  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)
+  Difference in Event Free Rate                         0.00             -8.99     
+    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)
+    p-value (Z-test)                                   1.0000            0.1406    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant5_9361964bea3808ccd24d986afabf9959">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb10-4"><a href="#cb10-4"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb10-5"><a href="#cb10-5"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb10-6"><a href="#cb10-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-8"><a href="#cb10-8"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb10-10"><a href="#cb10-10"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb10-11"><a href="#cb10-11"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb10-12"><a href="#cb10-12"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb10-13"><a href="#cb10-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb10-14"><a href="#cb10-14"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb10-15"><a href="#cb10-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb10-19"><a href="#cb10-19"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb10-20"><a href="#cb10-20"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb10-21"><a href="#cb10-21"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb10-22"><a href="#cb10-22"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb10-26"><a href="#cb10-26"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb10-27"><a href="#cb10-27"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb10-38"><a href="#cb10-38"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb10-39"><a href="#cb10-39"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">time_point =</span> <span class="dv">6</span>,</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    <span class="at">method =</span> <span class="st">"both"</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>  )</span>
+<span id="cb10-44"><a href="#cb10-44"></a></span>
+<span id="cb10-45"><a href="#cb10-45"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb10-47"><a href="#cb10-47"></a></span>
+<span id="cb10-48"><a href="#cb10-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X        B: Placebo      C: Combination
+                                     (N=134)           (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Patients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  
+  Earliest contributing event                                                      
+    Death                               58               58                69      
+Patients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  
+Time to Event (Months)                                                             
+  Median                                NA               NA               9.4      
+    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   
+  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    
+  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  
+  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  
+Unstratified Analysis                                                              
+  p-value (log-rank)                                   0.9998            0.1541    
+  Hazard Ratio                                          1.00              1.29     
+  95% CI                                            (0.69, 1.44)      (0.91, 1.83) 
+6 Months                                                                           
+  Patients remaining at risk            97               97                90      
+  Event Free Rate (%)                 72.39             72.39            68.18     
+  95% CI                          (64.82, 79.96)   (64.82, 79.96)    (60.24, 76.13)
+  Difference in Event Free Rate                         0.00             -4.21     
+    95% CI                                         (-10.71, 10.71)   (-15.18, 6.77)
+    p-value (Z-test)                                   1.0000            0.4525    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-test="{&quot;result_v6&quot;:&quot;result&quot;}" data-hash="ttet01_cache/html/variant6_a7c99c7a716254af63e229b21619264c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb12-4"><a href="#cb12-4"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-5"><a href="#cb12-5"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb12-6"><a href="#cb12-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb12-7"><a href="#cb12-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-8"><a href="#cb12-8"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb12-9"><a href="#cb12-9"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb12-10"><a href="#cb12-10"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb12-11"><a href="#cb12-11"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb12-12"><a href="#cb12-12"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb12-13"><a href="#cb12-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb12-15"><a href="#cb12-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-16"><a href="#cb12-16"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb12-18"><a href="#cb12-18"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb12-19"><a href="#cb12-19"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb12-20"><a href="#cb12-20"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb12-21"><a href="#cb12-21"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb12-22"><a href="#cb12-22"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb12-23"><a href="#cb12-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb12-25"><a href="#cb12-25"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-26"><a href="#cb12-26"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb12-27"><a href="#cb12-27"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-28"><a href="#cb12-28"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb12-31"><a href="#cb12-31"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-32"><a href="#cb12-32"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb12-35"><a href="#cb12-35"></a>    <span class="at">.stats =</span> <span class="st">"pvalue"</span>,</span>
+<span id="cb12-36"><a href="#cb12-36"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-40"><a href="#cb12-40"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-41"><a href="#cb12-41"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb12-42"><a href="#cb12-42"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"wald"</span>),</span>
+<span id="cb12-43"><a href="#cb12-43"></a>    <span class="at">.stats =</span> <span class="st">"pvalue"</span>,</span>
+<span id="cb12-44"><a href="#cb12-44"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">pvalue =</span> 1L),</span>
+<span id="cb12-45"><a href="#cb12-45"></a>    <span class="at">table_names =</span> <span class="st">"coxph_wald_pvalue"</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb12-48"><a href="#cb12-48"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-49"><a href="#cb12-49"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb12-51"><a href="#cb12-51"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"likelihood"</span>),</span>
+<span id="cb12-52"><a href="#cb12-52"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">pvalue =</span> 1L, <span class="at">hr =</span> 2L, <span class="at">hr_ci =</span> 3L),</span>
+<span id="cb12-53"><a href="#cb12-53"></a>    <span class="at">table_names =</span> <span class="st">"coxph_likelihood_pvalue"</span></span>
+<span id="cb12-54"><a href="#cb12-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-55"><a href="#cb12-55"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb12-56"><a href="#cb12-56"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb12-57"><a href="#cb12-57"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb12-58"><a href="#cb12-58"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb12-59"><a href="#cb12-59"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb12-60"><a href="#cb12-60"></a>    <span class="at">method =</span> <span class="st">"both"</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>  )</span>
+<span id="cb12-62"><a href="#cb12-62"></a></span>
+<span id="cb12-63"><a href="#cb12-63"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb12-65"><a href="#cb12-65"></a></span>
+<span id="cb12-66"><a href="#cb12-66"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                    A: Drug X        B: Placebo      C: Combination
+                                     (N=134)           (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Patients with event (%)             58 (43.3%)       58 (43.3%)        69 (52.3%)  
+  Earliest contributing event                                                      
+    Death                               58               58                69      
+Patients without event (%)          76 (56.7%)       76 (56.7%)        63 (47.7%)  
+Time to Event (Months)                                                             
+  Median                                NA               NA               9.4      
+    95% CI                          (9.3, NA)         (9.4, NA)        (7.6, NA)   
+  25% and 75%-ile                    5.6, NA           5.6, NA          5.0, NA    
+  Range (censored)                 9.9 to 16.4       9.9 to 16.3      9.9 to 16.3  
+  Range (event)                     0.5 to 9.6       0.9 to 9.6        0.5 to 9.8  
+Unstratified Analysis                                                              
+  p-value (log-rank)                                   0.9998            0.1541    
+  p-value (wald)                                       0.9998            0.1552    
+  p-value (likelihood)                                 0.9998            0.1543    
+    Hazard Ratio                                        1.00              1.29     
+      95% CI                                        (0.69, 1.44)      (0.91, 1.83) 
+12 Months                                                                          
+  Patients remaining at risk            49               48                37      
+  Event Free Rate (%)                 56.72             56.72            47.73     
+  95% CI                          (48.33, 65.11)   (48.33, 65.11)    (39.21, 56.25)
+  Difference in Event Free Rate                         0.00             -8.99     
+    95% CI                                         (-11.86, 11.86)   (-20.95, 2.97)
+    p-value (Z-test)                                   1.0000            0.1406    </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="ttet01_cache/html/teal_73f9270f21a41c4503c7b55332e1bc7a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-3"><a href="#cb14-3"></a></span>
+<span id="cb14-4"><a href="#cb14-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-5"><a href="#cb14-5"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb14-6"><a href="#cb14-6"></a></span>
+<span id="cb14-7"><a href="#cb14-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-8"><a href="#cb14-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-9"><a href="#cb14-9"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb14-10"><a href="#cb14-10"></a></span>
+<span id="cb14-11"><a href="#cb14-11"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb14-12"><a href="#cb14-12"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb14-13"><a href="#cb14-13"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb14-14"><a href="#cb14-14"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb14-15"><a href="#cb14-15"></a>  ),</span>
+<span id="cb14-16"><a href="#cb14-16"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb14-17"><a href="#cb14-17"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb14-18"><a href="#cb14-18"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb14-19"><a href="#cb14-19"></a>  )</span>
+<span id="cb14-20"><a href="#cb14-20"></a>)</span>
+<span id="cb14-21"><a href="#cb14-21"></a></span>
+<span id="cb14-22"><a href="#cb14-22"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-23"><a href="#cb14-23"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-24"><a href="#cb14-24"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb14-25"><a href="#cb14-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb14-26"><a href="#cb14-26"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-27"><a href="#cb14-27"></a>  ),</span>
+<span id="cb14-28"><a href="#cb14-28"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-29"><a href="#cb14-29"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb14-30"><a href="#cb14-30"></a>      <span class="at">label =</span> <span class="st">"Time To Event Table"</span>,</span>
+<span id="cb14-31"><a href="#cb14-31"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb14-32"><a href="#cb14-32"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-33"><a href="#cb14-33"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb14-34"><a href="#cb14-34"></a>        <span class="st">"ARM"</span></span>
+<span id="cb14-35"><a href="#cb14-35"></a>      ),</span>
+<span id="cb14-36"><a href="#cb14-36"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb14-37"><a href="#cb14-37"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-38"><a href="#cb14-38"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb14-39"><a href="#cb14-39"></a>        <span class="st">"OS"</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>      ),</span>
+<span id="cb14-41"><a href="#cb14-41"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-42"><a href="#cb14-42"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb14-43"><a href="#cb14-43"></a>        <span class="st">"SEX"</span></span>
+<span id="cb14-44"><a href="#cb14-44"></a>      ),</span>
+<span id="cb14-45"><a href="#cb14-45"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">8</span>), <span class="dv">6</span>),</span>
+<span id="cb14-46"><a href="#cb14-46"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-47"><a href="#cb14-47"></a>        <span class="fu">variable_choices</span>(adtte, <span class="st">"EVNTDESC"</span>),</span>
+<span id="cb14-48"><a href="#cb14-48"></a>        <span class="st">"EVNTDESC"</span>,</span>
+<span id="cb14-49"><a href="#cb14-49"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a>      )</span>
+<span id="cb14-51"><a href="#cb14-51"></a>    )</span>
+<span id="cb14-52"><a href="#cb14-52"></a>  )</span>
+<span id="cb14-53"><a href="#cb14-53"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 10:58:12.0132 pid:7363 token:[] teal.modules.clinical Initializing tm_t_tte</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb16"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb16-1"><a href="#cb16-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ttet01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-9" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-9-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ttet01_cache/html/sessioninfo_c6f06477fd627cb3c1edf4e8a4c32b6a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ttet01_cache/html/snapshot_a2b0a9d11202ae8fcdb87e4a236de509">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb19"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb19-1"><a href="#cb19-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb19-2"><a href="#cb19-2"></a></span>
+<span id="cb19-3"><a href="#cb19-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb19-4"><a href="#cb19-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb19-5"><a href="#cb19-5"></a></span>
+<span id="cb19-6"><a href="#cb19-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb19-7"><a href="#cb19-7"></a></span>
+<span id="cb19-8"><a href="#cb19-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb19-9"><a href="#cb19-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb19-10"><a href="#cb19-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb19-11"><a href="#cb19-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/efficacy/ttet01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/efficacy/rspt01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">RSPT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/exposure/ext01.html" class="pagination-link">
+        <span class="nav-page-text">EXT01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb20" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb20-1"><a href="#cb20-1"></a><span class="co">---</span></span>
+<span id="cb20-2"><a href="#cb20-2"></a><span class="an">title:</span><span class="co"> TTET01</span></span>
+<span id="cb20-3"><a href="#cb20-3"></a><span class="an">subtitle:</span><span class="co"> Time-To-Event Summary</span></span>
+<span id="cb20-4"><a href="#cb20-4"></a><span class="co">---</span></span>
+<span id="cb20-5"><a href="#cb20-5"></a></span>
+<span id="cb20-6"><a href="#cb20-6"></a>------------------------------------------------------------------------</span>
+<span id="cb20-7"><a href="#cb20-7"></a></span>
+<span id="cb20-8"><a href="#cb20-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb20-9"><a href="#cb20-9"></a></span>
+<span id="cb20-10"><a href="#cb20-10"></a>::: panel-tabset</span>
+<span id="cb20-11"><a href="#cb20-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb20-12"><a href="#cb20-12"></a></span>
+<span id="cb20-13"><a href="#cb20-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb20-14"><a href="#cb20-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb20-15"><a href="#cb20-15"></a></span>
+<span id="cb20-16"><a href="#cb20-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb20-17"><a href="#cb20-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb20-18"><a href="#cb20-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb20-19"><a href="#cb20-19"></a></span>
+<span id="cb20-20"><a href="#cb20-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb20-21"><a href="#cb20-21"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb20-22"><a href="#cb20-22"></a></span>
+<span id="cb20-23"><a href="#cb20-23"></a><span class="co"># Ensure that character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb20-24"><a href="#cb20-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb20-25"><a href="#cb20-25"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb20-26"><a href="#cb20-26"></a></span>
+<span id="cb20-27"><a href="#cb20-27"></a>adtte_f <span class="ot">&lt;-</span> adtte <span class="sc">%&gt;%</span></span>
+<span id="cb20-28"><a href="#cb20-28"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"OS"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-29"><a href="#cb20-29"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb20-30"><a href="#cb20-30"></a>    <span class="at">AVAL =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb20-31"><a href="#cb20-31"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>,</span>
+<span id="cb20-32"><a href="#cb20-32"></a>    <span class="at">is_not_event =</span> CNSR <span class="sc">==</span> <span class="dv">1</span>,</span>
+<span id="cb20-33"><a href="#cb20-33"></a>    <span class="at">EVNT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb20-34"><a href="#cb20-34"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb20-35"><a href="#cb20-35"></a>        is_event <span class="sc">==</span> <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Patients with event (%)"</span>,</span>
+<span id="cb20-36"><a href="#cb20-36"></a>        is_event <span class="sc">==</span> <span class="cn">FALSE</span> <span class="sc">~</span> <span class="st">"Patients without event (%)"</span></span>
+<span id="cb20-37"><a href="#cb20-37"></a>      ),</span>
+<span id="cb20-38"><a href="#cb20-38"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Patients with event (%)"</span>, <span class="st">"Patients without event (%)"</span>)</span>
+<span id="cb20-39"><a href="#cb20-39"></a>    ),</span>
+<span id="cb20-40"><a href="#cb20-40"></a>    <span class="at">EVNTDESC =</span> <span class="fu">factor</span>(EVNTDESC)</span>
+<span id="cb20-41"><a href="#cb20-41"></a>  )</span>
+<span id="cb20-42"><a href="#cb20-42"></a><span class="in">```</span></span>
+<span id="cb20-43"><a href="#cb20-43"></a></span>
+<span id="cb20-44"><a href="#cb20-44"></a><span class="fu">## Standard Table</span></span>
+<span id="cb20-45"><a href="#cb20-45"></a></span>
+<span id="cb20-46"><a href="#cb20-46"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb20-47"><a href="#cb20-47"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-48"><a href="#cb20-48"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb20-49"><a href="#cb20-49"></a>    <span class="at">var =</span> <span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb20-50"><a href="#cb20-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-51"><a href="#cb20-51"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-52"><a href="#cb20-52"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-53"><a href="#cb20-53"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-54"><a href="#cb20-54"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-55"><a href="#cb20-55"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-56"><a href="#cb20-56"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb20-57"><a href="#cb20-57"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb20-58"><a href="#cb20-58"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb20-59"><a href="#cb20-59"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb20-60"><a href="#cb20-60"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb20-61"><a href="#cb20-61"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-62"><a href="#cb20-62"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb20-63"><a href="#cb20-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-64"><a href="#cb20-64"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-65"><a href="#cb20-65"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-66"><a href="#cb20-66"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-67"><a href="#cb20-67"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-68"><a href="#cb20-68"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-69"><a href="#cb20-69"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-70"><a href="#cb20-70"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-71"><a href="#cb20-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-72"><a href="#cb20-72"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-73"><a href="#cb20-73"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-74"><a href="#cb20-74"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-75"><a href="#cb20-75"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-76"><a href="#cb20-76"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-77"><a href="#cb20-77"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-78"><a href="#cb20-78"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-79"><a href="#cb20-79"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-80"><a href="#cb20-80"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-81"><a href="#cb20-81"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb20-82"><a href="#cb20-82"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb20-83"><a href="#cb20-83"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-84"><a href="#cb20-84"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-85"><a href="#cb20-85"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-86"><a href="#cb20-86"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-87"><a href="#cb20-87"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-88"><a href="#cb20-88"></a>    <span class="at">time_point =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">12</span>),</span>
+<span id="cb20-89"><a href="#cb20-89"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-90"><a href="#cb20-90"></a>    <span class="at">method =</span> <span class="st">"both"</span>,</span>
+<span id="cb20-91"><a href="#cb20-91"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>()</span>
+<span id="cb20-92"><a href="#cb20-92"></a>  )</span>
+<span id="cb20-93"><a href="#cb20-93"></a></span>
+<span id="cb20-94"><a href="#cb20-94"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb20-95"><a href="#cb20-95"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb20-96"><a href="#cb20-96"></a></span>
+<span id="cb20-97"><a href="#cb20-97"></a>result</span>
+<span id="cb20-98"><a href="#cb20-98"></a><span class="in">```</span></span>
+<span id="cb20-99"><a href="#cb20-99"></a></span>
+<span id="cb20-100"><a href="#cb20-100"></a><span class="fu">## Table Selecting &lt;br/&gt; Sections to Display</span></span>
+<span id="cb20-101"><a href="#cb20-101"></a></span>
+<span id="cb20-102"><a href="#cb20-102"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb20-103"><a href="#cb20-103"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-104"><a href="#cb20-104"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-105"><a href="#cb20-105"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-106"><a href="#cb20-106"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-107"><a href="#cb20-107"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-108"><a href="#cb20-108"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-109"><a href="#cb20-109"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-110"><a href="#cb20-110"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-111"><a href="#cb20-111"></a>    <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-112"><a href="#cb20-112"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-113"><a href="#cb20-113"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-114"><a href="#cb20-114"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-115"><a href="#cb20-115"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-116"><a href="#cb20-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-117"><a href="#cb20-117"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-118"><a href="#cb20-118"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-119"><a href="#cb20-119"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-120"><a href="#cb20-120"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-121"><a href="#cb20-121"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-122"><a href="#cb20-122"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-123"><a href="#cb20-123"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-124"><a href="#cb20-124"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-125"><a href="#cb20-125"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-126"><a href="#cb20-126"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb20-127"><a href="#cb20-127"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb20-128"><a href="#cb20-128"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-129"><a href="#cb20-129"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-130"><a href="#cb20-130"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-131"><a href="#cb20-131"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-132"><a href="#cb20-132"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-133"><a href="#cb20-133"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-134"><a href="#cb20-134"></a>    <span class="at">method =</span> <span class="st">"surv"</span>,</span>
+<span id="cb20-135"><a href="#cb20-135"></a>    <span class="at">time_point =</span> <span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">12</span>)</span>
+<span id="cb20-136"><a href="#cb20-136"></a>  )</span>
+<span id="cb20-137"><a href="#cb20-137"></a></span>
+<span id="cb20-138"><a href="#cb20-138"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb20-139"><a href="#cb20-139"></a>result</span>
+<span id="cb20-140"><a href="#cb20-140"></a><span class="in">```</span></span>
+<span id="cb20-141"><a href="#cb20-141"></a></span>
+<span id="cb20-142"><a href="#cb20-142"></a><span class="fu">## Table Modifying Analysis Details &lt;br/&gt; like Conf. Type, Ties, Alpha Level</span></span>
+<span id="cb20-143"><a href="#cb20-143"></a></span>
+<span id="cb20-144"><a href="#cb20-144"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb20-145"><a href="#cb20-145"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-146"><a href="#cb20-146"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-147"><a href="#cb20-147"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-148"><a href="#cb20-148"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-149"><a href="#cb20-149"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-150"><a href="#cb20-150"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-151"><a href="#cb20-151"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-152"><a href="#cb20-152"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb20-153"><a href="#cb20-153"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb20-154"><a href="#cb20-154"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb20-155"><a href="#cb20-155"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb20-156"><a href="#cb20-156"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb20-157"><a href="#cb20-157"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-158"><a href="#cb20-158"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb20-159"><a href="#cb20-159"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-160"><a href="#cb20-160"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-161"><a href="#cb20-161"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-162"><a href="#cb20-162"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-163"><a href="#cb20-163"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-164"><a href="#cb20-164"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-165"><a href="#cb20-165"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-166"><a href="#cb20-166"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-167"><a href="#cb20-167"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-168"><a href="#cb20-168"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-169"><a href="#cb20-169"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-170"><a href="#cb20-170"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-171"><a href="#cb20-171"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-172"><a href="#cb20-172"></a>    <span class="at">control =</span> <span class="fu">control_surv_time</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>),</span>
+<span id="cb20-173"><a href="#cb20-173"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-174"><a href="#cb20-174"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-175"><a href="#cb20-175"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-176"><a href="#cb20-176"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-177"><a href="#cb20-177"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-178"><a href="#cb20-178"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb20-179"><a href="#cb20-179"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(</span>
+<span id="cb20-180"><a href="#cb20-180"></a>      <span class="at">pval_method =</span> <span class="st">"log-rank"</span>,</span>
+<span id="cb20-181"><a href="#cb20-181"></a>      <span class="at">conf_level =</span> <span class="fl">0.95</span>,</span>
+<span id="cb20-182"><a href="#cb20-182"></a>      <span class="at">ties =</span> <span class="st">"efron"</span></span>
+<span id="cb20-183"><a href="#cb20-183"></a>    ),</span>
+<span id="cb20-184"><a href="#cb20-184"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-185"><a href="#cb20-185"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-186"><a href="#cb20-186"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-187"><a href="#cb20-187"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-188"><a href="#cb20-188"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-189"><a href="#cb20-189"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-190"><a href="#cb20-190"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb20-191"><a href="#cb20-191"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.9</span>, <span class="at">conf_type =</span> <span class="st">"log-log"</span>),</span>
+<span id="cb20-192"><a href="#cb20-192"></a>    <span class="at">table_names_suffix =</span> <span class="st">"_log_log"</span></span>
+<span id="cb20-193"><a href="#cb20-193"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-194"><a href="#cb20-194"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-195"><a href="#cb20-195"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-196"><a href="#cb20-196"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-197"><a href="#cb20-197"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-198"><a href="#cb20-198"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb20-199"><a href="#cb20-199"></a>    <span class="at">method =</span> <span class="st">"surv_diff"</span>,</span>
+<span id="cb20-200"><a href="#cb20-200"></a>    <span class="at">control =</span> <span class="fu">control_surv_timepoint</span>(<span class="at">conf_level =</span> <span class="fl">0.975</span>),</span>
+<span id="cb20-201"><a href="#cb20-201"></a>    <span class="at">table_names_suffix =</span> <span class="st">"_975_pct"</span></span>
+<span id="cb20-202"><a href="#cb20-202"></a>  )</span>
+<span id="cb20-203"><a href="#cb20-203"></a></span>
+<span id="cb20-204"><a href="#cb20-204"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb20-205"><a href="#cb20-205"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb20-206"><a href="#cb20-206"></a></span>
+<span id="cb20-207"><a href="#cb20-207"></a>result</span>
+<span id="cb20-208"><a href="#cb20-208"></a><span class="in">```</span></span>
+<span id="cb20-209"><a href="#cb20-209"></a></span>
+<span id="cb20-210"><a href="#cb20-210"></a><span class="fu">## Table with &lt;br/&gt; Stratified Analysis</span></span>
+<span id="cb20-211"><a href="#cb20-211"></a></span>
+<span id="cb20-212"><a href="#cb20-212"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb20-213"><a href="#cb20-213"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-214"><a href="#cb20-214"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-215"><a href="#cb20-215"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-216"><a href="#cb20-216"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-217"><a href="#cb20-217"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-218"><a href="#cb20-218"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-219"><a href="#cb20-219"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-220"><a href="#cb20-220"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb20-221"><a href="#cb20-221"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb20-222"><a href="#cb20-222"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb20-223"><a href="#cb20-223"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb20-224"><a href="#cb20-224"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb20-225"><a href="#cb20-225"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-226"><a href="#cb20-226"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb20-227"><a href="#cb20-227"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-228"><a href="#cb20-228"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-229"><a href="#cb20-229"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-230"><a href="#cb20-230"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-231"><a href="#cb20-231"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-232"><a href="#cb20-232"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-233"><a href="#cb20-233"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-234"><a href="#cb20-234"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-235"><a href="#cb20-235"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-236"><a href="#cb20-236"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-237"><a href="#cb20-237"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-238"><a href="#cb20-238"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-239"><a href="#cb20-239"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-240"><a href="#cb20-240"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-241"><a href="#cb20-241"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-242"><a href="#cb20-242"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-243"><a href="#cb20-243"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-244"><a href="#cb20-244"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-245"><a href="#cb20-245"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb20-246"><a href="#cb20-246"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-247"><a href="#cb20-247"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-248"><a href="#cb20-248"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-249"><a href="#cb20-249"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-250"><a href="#cb20-250"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-251"><a href="#cb20-251"></a>    <span class="at">var_labels =</span> <span class="st">"Stratified Analysis"</span>,</span>
+<span id="cb20-252"><a href="#cb20-252"></a>    <span class="at">strat =</span> <span class="st">"SEX"</span>,</span>
+<span id="cb20-253"><a href="#cb20-253"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb20-254"><a href="#cb20-254"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-255"><a href="#cb20-255"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-256"><a href="#cb20-256"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-257"><a href="#cb20-257"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-258"><a href="#cb20-258"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-259"><a href="#cb20-259"></a>    <span class="at">method =</span> <span class="st">"both"</span>,</span>
+<span id="cb20-260"><a href="#cb20-260"></a>    <span class="at">time_point =</span> <span class="dv">12</span></span>
+<span id="cb20-261"><a href="#cb20-261"></a>  )</span>
+<span id="cb20-262"><a href="#cb20-262"></a></span>
+<span id="cb20-263"><a href="#cb20-263"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb20-264"><a href="#cb20-264"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb20-265"><a href="#cb20-265"></a></span>
+<span id="cb20-266"><a href="#cb20-266"></a>result</span>
+<span id="cb20-267"><a href="#cb20-267"></a><span class="in">```</span></span>
+<span id="cb20-268"><a href="#cb20-268"></a></span>
+<span id="cb20-269"><a href="#cb20-269"></a><span class="fu">## Table Modifying Time Point for &lt;br/&gt; the "XX Months" Analysis</span></span>
+<span id="cb20-270"><a href="#cb20-270"></a></span>
+<span id="cb20-271"><a href="#cb20-271"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb20-272"><a href="#cb20-272"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-273"><a href="#cb20-273"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-274"><a href="#cb20-274"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-275"><a href="#cb20-275"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-276"><a href="#cb20-276"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-277"><a href="#cb20-277"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-278"><a href="#cb20-278"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-279"><a href="#cb20-279"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb20-280"><a href="#cb20-280"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb20-281"><a href="#cb20-281"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb20-282"><a href="#cb20-282"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb20-283"><a href="#cb20-283"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb20-284"><a href="#cb20-284"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-285"><a href="#cb20-285"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb20-286"><a href="#cb20-286"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-287"><a href="#cb20-287"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-288"><a href="#cb20-288"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-289"><a href="#cb20-289"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-290"><a href="#cb20-290"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-291"><a href="#cb20-291"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-292"><a href="#cb20-292"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-293"><a href="#cb20-293"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-294"><a href="#cb20-294"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-295"><a href="#cb20-295"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-296"><a href="#cb20-296"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-297"><a href="#cb20-297"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-298"><a href="#cb20-298"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-299"><a href="#cb20-299"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-300"><a href="#cb20-300"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-301"><a href="#cb20-301"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-302"><a href="#cb20-302"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-303"><a href="#cb20-303"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-304"><a href="#cb20-304"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb20-305"><a href="#cb20-305"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb20-306"><a href="#cb20-306"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-307"><a href="#cb20-307"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-308"><a href="#cb20-308"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-309"><a href="#cb20-309"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-310"><a href="#cb20-310"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-311"><a href="#cb20-311"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-312"><a href="#cb20-312"></a>    <span class="at">time_point =</span> <span class="dv">6</span>,</span>
+<span id="cb20-313"><a href="#cb20-313"></a>    <span class="at">method =</span> <span class="st">"both"</span></span>
+<span id="cb20-314"><a href="#cb20-314"></a>  )</span>
+<span id="cb20-315"><a href="#cb20-315"></a></span>
+<span id="cb20-316"><a href="#cb20-316"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb20-317"><a href="#cb20-317"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb20-318"><a href="#cb20-318"></a></span>
+<span id="cb20-319"><a href="#cb20-319"></a>result</span>
+<span id="cb20-320"><a href="#cb20-320"></a><span class="in">```</span></span>
+<span id="cb20-321"><a href="#cb20-321"></a></span>
+<span id="cb20-322"><a href="#cb20-322"></a><span class="fu">## Table Requesting &lt;br/&gt; \&gt; 1 p-value</span></span>
+<span id="cb20-323"><a href="#cb20-323"></a></span>
+<span id="cb20-324"><a href="#cb20-324"></a><span class="in">```{r variant6, test = list(result_v6 = "result")}</span></span>
+<span id="cb20-325"><a href="#cb20-325"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-326"><a href="#cb20-326"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-327"><a href="#cb20-327"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-328"><a href="#cb20-328"></a>    <span class="at">vars =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-329"><a href="#cb20-329"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-330"><a href="#cb20-330"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients with event (%)"</span>)</span>
+<span id="cb20-331"><a href="#cb20-331"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-332"><a href="#cb20-332"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb20-333"><a href="#cb20-333"></a>    <span class="st">"EVNT1"</span>,</span>
+<span id="cb20-334"><a href="#cb20-334"></a>    <span class="at">split_label =</span> <span class="st">"Earliest contributing event"</span>,</span>
+<span id="cb20-335"><a href="#cb20-335"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="st">"Patients with event (%)"</span>),</span>
+<span id="cb20-336"><a href="#cb20-336"></a>    <span class="at">label_pos =</span> <span class="st">"visible"</span>,</span>
+<span id="cb20-337"><a href="#cb20-337"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-338"><a href="#cb20-338"></a>    <span class="at">indent_mod =</span> 1L,</span>
+<span id="cb20-339"><a href="#cb20-339"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-340"><a href="#cb20-340"></a>  <span class="fu">analyze</span>(<span class="st">"EVNTDESC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb20-341"><a href="#cb20-341"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb20-342"><a href="#cb20-342"></a>    <span class="at">vars =</span> <span class="st">"is_not_event"</span>,</span>
+<span id="cb20-343"><a href="#cb20-343"></a>    <span class="at">.stats =</span> <span class="st">"count_fraction"</span>,</span>
+<span id="cb20-344"><a href="#cb20-344"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count_fraction =</span> <span class="st">"Patients without event (%)"</span>),</span>
+<span id="cb20-345"><a href="#cb20-345"></a>    <span class="at">nested =</span> <span class="cn">FALSE</span>,</span>
+<span id="cb20-346"><a href="#cb20-346"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb20-347"><a href="#cb20-347"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-348"><a href="#cb20-348"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb20-349"><a href="#cb20-349"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-350"><a href="#cb20-350"></a>    <span class="at">var_labels =</span> <span class="st">"Time to Event (Months)"</span>,</span>
+<span id="cb20-351"><a href="#cb20-351"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-352"><a href="#cb20-352"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb20-353"><a href="#cb20-353"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-354"><a href="#cb20-354"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-355"><a href="#cb20-355"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-356"><a href="#cb20-356"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-357"><a href="#cb20-357"></a>    <span class="at">var_labels =</span> <span class="fu">c</span>(<span class="st">"Unstratified Analysis"</span>),</span>
+<span id="cb20-358"><a href="#cb20-358"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb20-359"><a href="#cb20-359"></a>    <span class="at">.stats =</span> <span class="st">"pvalue"</span>,</span>
+<span id="cb20-360"><a href="#cb20-360"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb20-361"><a href="#cb20-361"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-362"><a href="#cb20-362"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-363"><a href="#cb20-363"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-364"><a href="#cb20-364"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-365"><a href="#cb20-365"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-366"><a href="#cb20-366"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"wald"</span>),</span>
+<span id="cb20-367"><a href="#cb20-367"></a>    <span class="at">.stats =</span> <span class="st">"pvalue"</span>,</span>
+<span id="cb20-368"><a href="#cb20-368"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">pvalue =</span> 1L),</span>
+<span id="cb20-369"><a href="#cb20-369"></a>    <span class="at">table_names =</span> <span class="st">"coxph_wald_pvalue"</span></span>
+<span id="cb20-370"><a href="#cb20-370"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-371"><a href="#cb20-371"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb20-372"><a href="#cb20-372"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-373"><a href="#cb20-373"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-374"><a href="#cb20-374"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span>,</span>
+<span id="cb20-375"><a href="#cb20-375"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"likelihood"</span>),</span>
+<span id="cb20-376"><a href="#cb20-376"></a>    <span class="at">.indent_mods =</span> <span class="fu">c</span>(<span class="at">pvalue =</span> 1L, <span class="at">hr =</span> 2L, <span class="at">hr_ci =</span> 3L),</span>
+<span id="cb20-377"><a href="#cb20-377"></a>    <span class="at">table_names =</span> <span class="st">"coxph_likelihood_pvalue"</span></span>
+<span id="cb20-378"><a href="#cb20-378"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb20-379"><a href="#cb20-379"></a>  <span class="fu">surv_timepoint</span>(</span>
+<span id="cb20-380"><a href="#cb20-380"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb20-381"><a href="#cb20-381"></a>    <span class="at">var_labels =</span> <span class="st">"Months"</span>,</span>
+<span id="cb20-382"><a href="#cb20-382"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb20-383"><a href="#cb20-383"></a>    <span class="at">time_point =</span> <span class="dv">12</span>,</span>
+<span id="cb20-384"><a href="#cb20-384"></a>    <span class="at">method =</span> <span class="st">"both"</span></span>
+<span id="cb20-385"><a href="#cb20-385"></a>  )</span>
+<span id="cb20-386"><a href="#cb20-386"></a></span>
+<span id="cb20-387"><a href="#cb20-387"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adtte_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb20-388"><a href="#cb20-388"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb20-389"><a href="#cb20-389"></a></span>
+<span id="cb20-390"><a href="#cb20-390"></a>result</span>
+<span id="cb20-391"><a href="#cb20-391"></a><span class="in">```</span></span>
+<span id="cb20-392"><a href="#cb20-392"></a></span>
+<span id="cb20-393"><a href="#cb20-393"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb20-394"><a href="#cb20-394"></a></span>
+<span id="cb20-395"><a href="#cb20-395"></a><span class="fu">## `teal` App</span></span>
+<span id="cb20-396"><a href="#cb20-396"></a></span>
+<span id="cb20-397"><a href="#cb20-397"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb20-398"><a href="#cb20-398"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb20-399"><a href="#cb20-399"></a></span>
+<span id="cb20-400"><a href="#cb20-400"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb20-401"><a href="#cb20-401"></a><span class="fu">library</span>(scda)</span>
+<span id="cb20-402"><a href="#cb20-402"></a></span>
+<span id="cb20-403"><a href="#cb20-403"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb20-404"><a href="#cb20-404"></a>adtte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adtte"</span>)</span>
+<span id="cb20-405"><a href="#cb20-405"></a></span>
+<span id="cb20-406"><a href="#cb20-406"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb20-407"><a href="#cb20-407"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb20-408"><a href="#cb20-408"></a>adtte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adtte)</span>
+<span id="cb20-409"><a href="#cb20-409"></a></span>
+<span id="cb20-410"><a href="#cb20-410"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb20-411"><a href="#cb20-411"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb20-412"><a href="#cb20-412"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb20-413"><a href="#cb20-413"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb20-414"><a href="#cb20-414"></a>  ),</span>
+<span id="cb20-415"><a href="#cb20-415"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb20-416"><a href="#cb20-416"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb20-417"><a href="#cb20-417"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb20-418"><a href="#cb20-418"></a>  )</span>
+<span id="cb20-419"><a href="#cb20-419"></a>)</span>
+<span id="cb20-420"><a href="#cb20-420"></a></span>
+<span id="cb20-421"><a href="#cb20-421"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb20-422"><a href="#cb20-422"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb20-423"><a href="#cb20-423"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb20-424"><a href="#cb20-424"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADTTE"</span>, adtte, <span class="at">code =</span> <span class="st">'ADTTE &lt;- synthetic_cdisc_dataset("latest", "adtte") %&gt;% df_explicit_na()'</span>),</span>
+<span id="cb20-425"><a href="#cb20-425"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb20-426"><a href="#cb20-426"></a>  ),</span>
+<span id="cb20-427"><a href="#cb20-427"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb20-428"><a href="#cb20-428"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb20-429"><a href="#cb20-429"></a>      <span class="at">label =</span> <span class="st">"Time To Event Table"</span>,</span>
+<span id="cb20-430"><a href="#cb20-430"></a>      <span class="at">dataname =</span> <span class="st">"ADTTE"</span>,</span>
+<span id="cb20-431"><a href="#cb20-431"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-432"><a href="#cb20-432"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb20-433"><a href="#cb20-433"></a>        <span class="st">"ARM"</span></span>
+<span id="cb20-434"><a href="#cb20-434"></a>      ),</span>
+<span id="cb20-435"><a href="#cb20-435"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb20-436"><a href="#cb20-436"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-437"><a href="#cb20-437"></a>        <span class="fu">value_choices</span>(adtte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb20-438"><a href="#cb20-438"></a>        <span class="st">"OS"</span></span>
+<span id="cb20-439"><a href="#cb20-439"></a>      ),</span>
+<span id="cb20-440"><a href="#cb20-440"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-441"><a href="#cb20-441"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"BMRKR2"</span>)),</span>
+<span id="cb20-442"><a href="#cb20-442"></a>        <span class="st">"SEX"</span></span>
+<span id="cb20-443"><a href="#cb20-443"></a>      ),</span>
+<span id="cb20-444"><a href="#cb20-444"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="dv">6</span>, <span class="dv">8</span>), <span class="dv">6</span>),</span>
+<span id="cb20-445"><a href="#cb20-445"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb20-446"><a href="#cb20-446"></a>        <span class="fu">variable_choices</span>(adtte, <span class="st">"EVNTDESC"</span>),</span>
+<span id="cb20-447"><a href="#cb20-447"></a>        <span class="st">"EVNTDESC"</span>,</span>
+<span id="cb20-448"><a href="#cb20-448"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb20-449"><a href="#cb20-449"></a>      )</span>
+<span id="cb20-450"><a href="#cb20-450"></a>    )</span>
+<span id="cb20-451"><a href="#cb20-451"></a>  )</span>
+<span id="cb20-452"><a href="#cb20-452"></a>)</span>
+<span id="cb20-453"><a href="#cb20-453"></a></span>
+<span id="cb20-454"><a href="#cb20-454"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb20-455"><a href="#cb20-455"></a><span class="in">```</span></span>
+<span id="cb20-456"><a href="#cb20-456"></a></span>
+<span id="cb20-457"><a href="#cb20-457"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb20-458"><a href="#cb20-458"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="true">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">EXT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Study Drug Exposure Table</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table with Optional Analyses</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with User-Specified <br> Categories for Missed Doses</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="ext01_cache/html/setup_26f3714653501e7226f4f671cf8e0109">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"OVERALL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, PARAM, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAMCD =</span> <span class="fu">as.character</span>(PARAMCD),</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">AVALC =</span> <span class="st">""</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a><span class="co"># Add new param tdurd for treatment duration.</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="fu">set.seed</span>(<span class="dv">99</span>)</span>
+<span id="cb1-24"><a href="#cb1-24"></a>tdurd_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">150</span>, <span class="at">size =</span> <span class="fu">nrow</span>(adsl), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">AVALC =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      <span class="dv">0</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"0 - 30"</span>,</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      <span class="dv">31</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"31 - 60"</span>,</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      <span class="dv">61</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">90</span> <span class="sc">~</span> <span class="st">"61 - 90"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;= 91"</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>    )</span>
+<span id="cb1-36"><a href="#cb1-36"></a>  )</span>
+<span id="cb1-37"><a href="#cb1-37"></a>tdurd <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">left_join</span>(tdurd_adsl, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb1-41"><a href="#cb1-41"></a></span>
+<span id="cb1-42"><a href="#cb1-42"></a><span class="co"># Add new param tndosmis for missed doses.</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>tndosmis_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">PARAMCD =</span> <span class="st">"TNDOSMIS"</span>,</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    <span class="at">PARAM =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="dv">0</span><span class="sc">:</span><span class="dv">20</span>, <span class="at">size =</span> <span class="fu">nrow</span>(adsl), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb1-49"><a href="#cb1-49"></a>    <span class="at">AVALC =</span> <span class="st">""</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  )</span>
+<span id="cb1-51"><a href="#cb1-51"></a>tndosmis <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a>  <span class="fu">left_join</span>(tndosmis_adsl, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb1-55"><a href="#cb1-55"></a></span>
+<span id="cb1-56"><a href="#cb1-56"></a>adex <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">bind_rows</span>(adex, tdurd, tndosmis) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-58"><a href="#cb1-58"></a>    PARAM,</span>
+<span id="cb1-59"><a href="#cb1-59"></a>    <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-60"><a href="#cb1-60"></a>      <span class="st">"Overall duration (days)"</span>, <span class="st">"Total dose administered"</span>, <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>      <span class="st">"Total number of missed doses during study"</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a>    )</span>
+<span id="cb1-63"><a href="#cb1-63"></a>  ))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="ext01_cache/html/variant1_425807da694600f999db725c31f93079">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># When summary table contains only categorical or only numeric parameters</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-4"><a href="#cb2-4"></a></span>
+<span id="cb2-5"><a href="#cb2-5"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a></span>
+<span id="cb2-11"><a href="#cb2-11"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adex, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                 A: Drug X        B: Placebo      C: Combination 
+Parameter Category (Drug A/Drug B)                (N=134)           (N=134)           (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————
+Drug A                                                                                           
+  Overall duration (days)                                                                        
+    n                                               75                67                75       
+    Mean (SD)                                   74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  
+    Median                                         77.0              80.0              78.0      
+    Min - Max                                   5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  
+  Total dose administered                                                                        
+    n                                               75                67                75       
+    Mean (SD)                                 6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)
+    Median                                        6720.0            6480.0            7200.0     
+    Min - Max                                 4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0
+  Total number of doses administered                                                             
+    n                                               75                67                75       
+    Mean (SD)                                    7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                          7.0               7.0               7.0      
+    Min - Max                                    7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   
+  Total number of missed doses during study                                                      
+    n                                               75                67                75       
+    Mean (SD)                                   10.5 (5.9)        10.0 (6.1)         9.5 (5.5)   
+    Median                                         10.0              11.0               9.0      
+    Min - Max                                   0.0 - 20.0        0.0 - 19.0        0.0 - 20.0   
+Drug B                                                                                           
+  Overall duration (days)                                                                        
+    n                                               59                67                57       
+    Mean (SD)                                   77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  
+    Median                                         79.0              76.0              65.0      
+    Min - Max                                   2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  
+  Total dose administered                                                                        
+    n                                               59                67                57       
+    Mean (SD)                                 6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)
+    Median                                        6720.0            6240.0            6480.0     
+    Min - Max                                 4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0
+  Total number of doses administered                                                             
+    n                                               59                67                57       
+    Mean (SD)                                    7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                          7.0               7.0               7.0      
+    Min - Max                                    7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   
+  Total number of missed doses during study                                                      
+    n                                               59                67                57       
+    Mean (SD)                                    9.1 (6.5)        10.0 (6.3)        10.7 (5.8)   
+    Median                                          9.0              10.0              11.0      
+    Min - Max                                   0.0 - 20.0        0.0 - 20.0        1.0 - 20.0   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="ext01_cache/html/variant2_97d15e0f138f9d3d40fa8f6ef64062db">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># When summary table contains both categorical and numeric parameters,</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="co"># developer needs to do pre-processing to transform dataset to wide format.</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>adex_avalc_wide <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, PARCAT2),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">TDURDC =</span> <span class="fu">factor</span>(TDURD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"0 - 30"</span>, <span class="st">"31 - 60"</span>, <span class="st">"61 - 90"</span>, <span class="st">"&gt;= 91"</span>))</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">select</span>(<span class="sc">-</span>TDURD)</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a>anl <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, ACTARM, PARCAT2),</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb4-22"><a href="#cb4-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a>  <span class="fu">left_join</span>(adex_avalc_wide, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARCAT2"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">TDOSE =</span> <span class="st">"Total dose administered"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="at">TNDOSE =</span> <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">TDURD =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">TNDOSMIS =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb4-29"><a href="#cb4-29"></a>    <span class="at">TDURDC =</span> <span class="st">"Overall duration (days)"</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  )</span>
+<span id="cb4-31"><a href="#cb4-31"></a></span>
+<span id="cb4-32"><a href="#cb4-32"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="at">var_labels =</span> <span class="fu">var_labels</span>(anl)[<span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)]</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  )</span>
+<span id="cb4-39"><a href="#cb4-39"></a></span>
+<span id="cb4-40"><a href="#cb4-40"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-41"><a href="#cb4-41"></a></span>
+<span id="cb4-42"><a href="#cb4-42"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                          A: Drug X        B: Placebo      C: Combination 
+Parameter Category (Drug A/Drug B)         (N=134)           (N=134)           (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————
+Drug A                                                                                    
+  Overall duration (days)                                                                 
+    n                                        75                67                75       
+    Mean (SD)                            74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  
+    Median                                  77.0              80.0              78.0      
+    Min - Max                            5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  
+  Overall duration (days)                                                                 
+    n                                        75                67                75       
+    0 - 30                                12 (16%)         12 (17.9%)         15 (20%)    
+    31 - 60                               18 (24%)         12 (17.9%)        14 (18.7%)   
+    61 - 90                              19 (25.3%)        15 (22.4%)         18 (24%)    
+    &gt;= 91                                26 (34.7%)        28 (41.8%)        28 (37.3%)   
+  Total dose administered                                                                 
+    n                                        75                67                75       
+    Mean (SD)                          6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)
+    Median                                 6720.0            6480.0            7200.0     
+    Min - Max                          4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0
+  Total number of doses administered                                                      
+    n                                        75                67                75       
+    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                   7.0               7.0               7.0      
+    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   
+Drug B                                                                                    
+  Overall duration (days)                                                                 
+    n                                        59                67                57       
+    Mean (SD)                            77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  
+    Median                                  79.0              76.0              65.0      
+    Min - Max                            2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  
+  Overall duration (days)                                                                 
+    n                                        59                67                57       
+    0 - 30                                8 (13.6%)        10 (14.9%)        16 (28.1%)   
+    31 - 60                              14 (23.7%)        16 (23.9%)        12 (21.1%)   
+    61 - 90                              15 (25.4%)        17 (25.4%)        11 (19.3%)   
+    &gt;= 91                                22 (37.3%)        24 (35.8%)        18 (31.6%)   
+  Total dose administered                                                                 
+    n                                        59                67                57       
+    Mean (SD)                          6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)
+    Median                                 6720.0            6240.0            6480.0     
+    Min - Max                          4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0
+  Total number of doses administered                                                      
+    n                                        59                67                57       
+    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                   7.0               7.0               7.0      
+    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="ext01_cache/html/variant3_7bd498f6431aee229f531cbbaba8cd7d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># When summary table contains both categorical and numeric parameters,</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="co"># developer needs to do pre-processing to transform dataset to wide format.</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>adex_avalc_wide <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, PARCAT2),</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">TDURDC =</span> <span class="fu">factor</span>(TDURD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"0 - 30"</span>, <span class="st">"31 - 60"</span>, <span class="st">"61 - 90"</span>, <span class="st">"&gt;= 91"</span>))</span>
+<span id="cb6-13"><a href="#cb6-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">select</span>(<span class="sc">-</span>TDURD)</span>
+<span id="cb6-15"><a href="#cb6-15"></a></span>
+<span id="cb6-16"><a href="#cb6-16"></a>anl <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, ACTARM, PARCAT2),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb6-22"><a href="#cb6-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>  <span class="fu">left_join</span>(adex_avalc_wide, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARCAT2"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">TDOSE =</span> <span class="st">"Total dose administered"</span>,</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">TNDOSE =</span> <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="at">TDURD =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">TNDOSMIS =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">TDURDC =</span> <span class="st">"Overall duration (days)"</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  )</span>
+<span id="cb6-31"><a href="#cb6-31"></a></span>
+<span id="cb6-32"><a href="#cb6-32"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-33"><a href="#cb6-33"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    <span class="at">var_labels =</span> <span class="fu">var_labels</span>(anl)[<span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)]</span>
+<span id="cb6-38"><a href="#cb6-38"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a>  <span class="fu">count_missed_doses</span>(</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="st">"TNDOSMIS"</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">thresholds =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">10</span>, <span class="dv">15</span>),</span>
+<span id="cb6-42"><a href="#cb6-42"></a>    <span class="at">var_labels =</span> <span class="st">"Missed Doses"</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a>  )</span>
+<span id="cb6-44"><a href="#cb6-44"></a></span>
+<span id="cb6-45"><a href="#cb6-45"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb6-46"><a href="#cb6-46"></a></span>
+<span id="cb6-47"><a href="#cb6-47"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                          A: Drug X        B: Placebo      C: Combination 
+Parameter Category (Drug A/Drug B)         (N=134)           (N=134)           (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————
+Drug A                                                                                    
+  Overall duration (days)                                                                 
+    n                                        75                67                75       
+    Mean (SD)                            74.3 (41.6)       79.0 (43.1)       74.2 (39.5)  
+    Median                                  77.0              80.0              78.0      
+    Min - Max                            5.0 - 149.0       2.0 - 150.0       1.0 - 147.0  
+  Overall duration (days)                                                                 
+    n                                        75                67                75       
+    0 - 30                                12 (16%)         12 (17.9%)         15 (20%)    
+    31 - 60                               18 (24%)         12 (17.9%)        14 (18.7%)   
+    61 - 90                              19 (25.3%)        15 (22.4%)         18 (24%)    
+    &gt;= 91                                26 (34.7%)        28 (41.8%)        28 (37.3%)   
+  Total dose administered                                                                 
+    n                                        75                67                75       
+    Mean (SD)                          6675.2 (1110.9)   6505.1 (1249.3)   6982.4 (1272.5)
+    Median                                 6720.0            6480.0            7200.0     
+    Min - Max                          4800.0 - 9360.0   4080.0 - 9360.0   4320.0 - 9360.0
+  Total number of doses administered                                                      
+    n                                        75                67                75       
+    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                   7.0               7.0               7.0      
+    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   
+  Missed Doses                                                                            
+    n                                        75                67                75       
+    At least 1 missed dose               74 (55.2%)         63 (47%)         73 (55.3%)   
+    At least 5 missed doses               59 (44%)         49 (36.6%)        59 (44.7%)   
+    At least 10 missed doses             41 (30.6%)        38 (28.4%)         37 (28%)    
+    At least 15 missed doses             26 (19.4%)        21 (15.7%)        16 (12.1%)   
+Drug B                                                                                    
+  Overall duration (days)                                                                 
+    n                                        59                67                57       
+    Mean (SD)                            77.5 (40.5)       76.3 (41.0)       69.5 (46.2)  
+    Median                                  79.0              76.0              65.0      
+    Min - Max                            2.0 - 149.0       5.0 - 148.0       1.0 - 149.0  
+  Overall duration (days)                                                                 
+    n                                        59                67                57       
+    0 - 30                                8 (13.6%)        10 (14.9%)        16 (28.1%)   
+    31 - 60                              14 (23.7%)        16 (23.9%)        12 (21.1%)   
+    61 - 90                              15 (25.4%)        17 (25.4%)        11 (19.3%)   
+    &gt;= 91                                22 (37.3%)        24 (35.8%)        18 (31.6%)   
+  Total dose administered                                                                 
+    n                                        59                67                57       
+    Mean (SD)                          6630.5 (1334.0)   6297.3 (1291.1)   6505.3 (1080.7)
+    Median                                 6720.0            6240.0            6480.0     
+    Min - Max                          4320.0 - 8880.0   4080.0 - 9120.0   4320.0 - 8640.0
+  Total number of doses administered                                                      
+    n                                        59                67                57       
+    Mean (SD)                             7.0 (0.0)         7.0 (0.0)         7.0 (0.0)   
+    Median                                   7.0               7.0               7.0      
+    Min - Max                             7.0 - 7.0         7.0 - 7.0         7.0 - 7.0   
+  Missed Doses                                                                            
+    n                                        59                67                57       
+    At least 1 missed dose               56 (41.8%)         63 (47%)         57 (43.2%)   
+    At least 5 missed doses              41 (30.6%)        50 (37.3%)        47 (35.6%)   
+    At least 10 missed doses             27 (20.1%)        36 (26.9%)        31 (23.5%)   
+    At least 15 missed doses             17 (12.7%)        18 (13.4%)        20 (15.2%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="ext01_cache/html/teal_1fd6c9e59cb48bc4b637b1eaab53324a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-4"><a href="#cb8-4"></a></span>
+<span id="cb8-5"><a href="#cb8-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb8-7"><a href="#cb8-7"></a>adex_labels <span class="ot">&lt;-</span> <span class="fu">unname</span>(<span class="fu">var_labels</span>(adex))</span>
+<span id="cb8-8"><a href="#cb8-8"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb8-9"><a href="#cb8-9"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"OVERALL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-12"><a href="#cb8-12"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> <span class="dv">5000</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> <span class="dv">5000</span> <span class="sc">~</span> <span class="st">"HIGH"</span>,</span>
+<span id="cb8-14"><a href="#cb8-14"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"&lt; 10"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"&gt;= 10"</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>    )</span>
+<span id="cb8-17"><a href="#cb8-17"></a>  )</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(adex_labels, <span class="st">""</span>)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb8-21"><a href="#cb8-21"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-22"><a href="#cb8-22"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-23"><a href="#cb8-23"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb8-24"><a href="#cb8-24"></a>      adsl,</span>
+<span id="cb8-25"><a href="#cb8-25"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a>    ),</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>      <span class="st">"ADEX"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>      adex,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>      <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a><span class="st">      ADEX_labels &lt;- unname(var_labels(ADEX))</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a><span class="st">      ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a><span class="st">        filter(PARCAT1 == "OVERALL") %&gt;%</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a><span class="st">        mutate(</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a><span class="st">          AVALCAT1 = case_when(</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a><span class="st">            PARAMCD == "TDOSE" &amp;  AVAL &lt; 5000 ~  "LOW",</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a><span class="st">            PARAMCD == "TDOSE" &amp;  AVAL &gt;= 5000 ~ "HIGH",</span></span>
+<span id="cb8-38"><a href="#cb8-38"></a><span class="st">            PARAMCD == "TNDOSE" &amp;  AVAL &lt; 10 ~  "&lt; 10",</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a><span class="st">            PARAMCD == "TNDOSE" &amp;  AVAL &gt;= 10 ~  "&gt;= 10")</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a><span class="st">        )</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a><span class="st">      var_labels(ADEX) &lt;- c(ADEX_labels, "")'</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>    ),</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  ),</span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb8-47"><a href="#cb8-47"></a>      <span class="at">label =</span> <span class="st">"Exposure Table"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-50"><a href="#cb8-50"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>      ),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"PARCAT2"</span>, <span class="st">"PARAM"</span>)),</span>
+<span id="cb8-55"><a href="#cb8-55"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARCAT2"</span>, <span class="st">"PARAM"</span>)</span>
+<span id="cb8-56"><a href="#cb8-56"></a>      ),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-58"><a href="#cb8-58"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"AVALCAT1"</span>)),</span>
+<span id="cb8-59"><a href="#cb8-59"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"AVALCAT1"</span>)</span>
+<span id="cb8-60"><a href="#cb8-60"></a>      ),</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-62"><a href="#cb8-62"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)</span>
+<span id="cb8-64"><a href="#cb8-64"></a>      ),</span>
+<span id="cb8-65"><a href="#cb8-65"></a>      <span class="at">denominator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-66"><a href="#cb8-66"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"N"</span>, <span class="st">"omit"</span>),</span>
+<span id="cb8-67"><a href="#cb8-67"></a>        <span class="at">selected =</span> <span class="st">"N"</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>      )</span>
+<span id="cb8-69"><a href="#cb8-69"></a>    )</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  ), <span class="co"># Set initial filter state as single study drug to produce smaller table</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADEX =</span> <span class="fu">list</span>(<span class="at">PARCAT2 =</span> <span class="st">"Drug A"</span>, <span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb8-72"><a href="#cb8-72"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:38:22.4584 pid:14172 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="ext01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="ext01_cache/html/sessioninfo_96404eaa9b4adbe16a7ef8a6baa4f2f0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tidyr_1.3.0                  dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            forcats_1.0.0         pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="ext01_cache/html/snapshot_d03ec3d7ad6df758c33ab053dfaee175">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/exposure/ext01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> EXT01</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Study Drug Exposure Table</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a><span class="fu">library</span>(tidyr)</span>
+<span id="cb14-20"><a href="#cb14-20"></a></span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb14-23"><a href="#cb14-23"></a></span>
+<span id="cb14-24"><a href="#cb14-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-25"><a href="#cb14-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-26"><a href="#cb14-26"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb14-27"><a href="#cb14-27"></a></span>
+<span id="cb14-28"><a href="#cb14-28"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-29"><a href="#cb14-29"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"OVERALL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, PARAM, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-31"><a href="#cb14-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-32"><a href="#cb14-32"></a>    <span class="at">PARAMCD =</span> <span class="fu">as.character</span>(PARAMCD),</span>
+<span id="cb14-33"><a href="#cb14-33"></a>    <span class="at">AVALC =</span> <span class="st">""</span></span>
+<span id="cb14-34"><a href="#cb14-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-35"><a href="#cb14-35"></a>  <span class="fu">droplevels</span>()</span>
+<span id="cb14-36"><a href="#cb14-36"></a></span>
+<span id="cb14-37"><a href="#cb14-37"></a><span class="co"># Add new param tdurd for treatment duration.</span></span>
+<span id="cb14-38"><a href="#cb14-38"></a><span class="fu">set.seed</span>(<span class="dv">99</span>)</span>
+<span id="cb14-39"><a href="#cb14-39"></a>tdurd_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb14-41"><a href="#cb14-41"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-42"><a href="#cb14-42"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb14-43"><a href="#cb14-43"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb14-44"><a href="#cb14-44"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">150</span>, <span class="at">size =</span> <span class="fu">nrow</span>(adsl), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb14-45"><a href="#cb14-45"></a>    <span class="at">AVALC =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-46"><a href="#cb14-46"></a>      <span class="dv">0</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">30</span> <span class="sc">~</span> <span class="st">"0 - 30"</span>,</span>
+<span id="cb14-47"><a href="#cb14-47"></a>      <span class="dv">31</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">60</span> <span class="sc">~</span> <span class="st">"31 - 60"</span>,</span>
+<span id="cb14-48"><a href="#cb14-48"></a>      <span class="dv">61</span> <span class="sc">&lt;=</span> AVAL <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> <span class="dv">90</span> <span class="sc">~</span> <span class="st">"61 - 90"</span>,</span>
+<span id="cb14-49"><a href="#cb14-49"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;= 91"</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a>    )</span>
+<span id="cb14-51"><a href="#cb14-51"></a>  )</span>
+<span id="cb14-52"><a href="#cb14-52"></a>tdurd <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-53"><a href="#cb14-53"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-54"><a href="#cb14-54"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-55"><a href="#cb14-55"></a>  <span class="fu">left_join</span>(tdurd_adsl, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb14-56"><a href="#cb14-56"></a></span>
+<span id="cb14-57"><a href="#cb14-57"></a><span class="co"># Add new param tndosmis for missed doses.</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a>tndosmis_adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb14-59"><a href="#cb14-59"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM) <span class="sc">%&gt;%</span></span>
+<span id="cb14-60"><a href="#cb14-60"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-61"><a href="#cb14-61"></a>    <span class="at">PARAMCD =</span> <span class="st">"TNDOSMIS"</span>,</span>
+<span id="cb14-62"><a href="#cb14-62"></a>    <span class="at">PARAM =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb14-63"><a href="#cb14-63"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="dv">0</span><span class="sc">:</span><span class="dv">20</span>, <span class="at">size =</span> <span class="fu">nrow</span>(adsl), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb14-64"><a href="#cb14-64"></a>    <span class="at">AVALC =</span> <span class="st">""</span></span>
+<span id="cb14-65"><a href="#cb14-65"></a>  )</span>
+<span id="cb14-66"><a href="#cb14-66"></a>tndosmis <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-67"><a href="#cb14-67"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-68"><a href="#cb14-68"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-69"><a href="#cb14-69"></a>  <span class="fu">left_join</span>(tndosmis_adsl, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>))</span>
+<span id="cb14-70"><a href="#cb14-70"></a></span>
+<span id="cb14-71"><a href="#cb14-71"></a>adex <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">bind_rows</span>(adex, tdurd, tndosmis) <span class="sc">%&gt;%</span></span>
+<span id="cb14-72"><a href="#cb14-72"></a>  <span class="fu">mutate</span>(<span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-73"><a href="#cb14-73"></a>    PARAM,</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-75"><a href="#cb14-75"></a>      <span class="st">"Overall duration (days)"</span>, <span class="st">"Total dose administered"</span>, <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb14-76"><a href="#cb14-76"></a>      <span class="st">"Total number of missed doses during study"</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>    )</span>
+<span id="cb14-78"><a href="#cb14-78"></a>  ))</span>
+<span id="cb14-79"><a href="#cb14-79"></a><span class="in">```</span></span>
+<span id="cb14-80"><a href="#cb14-80"></a></span>
+<span id="cb14-81"><a href="#cb14-81"></a><span class="fu">## Standard Table</span></span>
+<span id="cb14-82"><a href="#cb14-82"></a></span>
+<span id="cb14-83"><a href="#cb14-83"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb14-84"><a href="#cb14-84"></a><span class="co"># When summary table contains only categorical or only numeric parameters</span></span>
+<span id="cb14-85"><a href="#cb14-85"></a></span>
+<span id="cb14-86"><a href="#cb14-86"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb14-87"><a href="#cb14-87"></a></span>
+<span id="cb14-88"><a href="#cb14-88"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-90"><a href="#cb14-90"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-91"><a href="#cb14-91"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun) <span class="sc">%&gt;%</span></span>
+<span id="cb14-92"><a href="#cb14-92"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>)</span>
+<span id="cb14-93"><a href="#cb14-93"></a></span>
+<span id="cb14-94"><a href="#cb14-94"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adex, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb14-95"><a href="#cb14-95"></a></span>
+<span id="cb14-96"><a href="#cb14-96"></a>result</span>
+<span id="cb14-97"><a href="#cb14-97"></a><span class="in">```</span></span>
+<span id="cb14-98"><a href="#cb14-98"></a></span>
+<span id="cb14-99"><a href="#cb14-99"></a><span class="fu">## Table with Optional Analyses</span></span>
+<span id="cb14-100"><a href="#cb14-100"></a></span>
+<span id="cb14-101"><a href="#cb14-101"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb14-102"><a href="#cb14-102"></a><span class="co"># When summary table contains both categorical and numeric parameters,</span></span>
+<span id="cb14-103"><a href="#cb14-103"></a><span class="co"># developer needs to do pre-processing to transform dataset to wide format.</span></span>
+<span id="cb14-104"><a href="#cb14-104"></a>adex_avalc_wide <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-105"><a href="#cb14-105"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-107"><a href="#cb14-107"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb14-108"><a href="#cb14-108"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, PARCAT2),</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb14-110"><a href="#cb14-110"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb14-111"><a href="#cb14-111"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-112"><a href="#cb14-112"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-113"><a href="#cb14-113"></a>    <span class="at">TDURDC =</span> <span class="fu">factor</span>(TDURD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"0 - 30"</span>, <span class="st">"31 - 60"</span>, <span class="st">"61 - 90"</span>, <span class="st">"&gt;= 91"</span>))</span>
+<span id="cb14-114"><a href="#cb14-114"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-115"><a href="#cb14-115"></a>  <span class="fu">select</span>(<span class="sc">-</span>TDURD)</span>
+<span id="cb14-116"><a href="#cb14-116"></a></span>
+<span id="cb14-117"><a href="#cb14-117"></a>anl <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-118"><a href="#cb14-118"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-119"><a href="#cb14-119"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb14-120"><a href="#cb14-120"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, ACTARM, PARCAT2),</span>
+<span id="cb14-121"><a href="#cb14-121"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb14-122"><a href="#cb14-122"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb14-123"><a href="#cb14-123"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-124"><a href="#cb14-124"></a>  <span class="fu">left_join</span>(adex_avalc_wide, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARCAT2"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-125"><a href="#cb14-125"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb14-126"><a href="#cb14-126"></a>    <span class="at">TDOSE =</span> <span class="st">"Total dose administered"</span>,</span>
+<span id="cb14-127"><a href="#cb14-127"></a>    <span class="at">TNDOSE =</span> <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb14-128"><a href="#cb14-128"></a>    <span class="at">TDURD =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb14-129"><a href="#cb14-129"></a>    <span class="at">TNDOSMIS =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb14-130"><a href="#cb14-130"></a>    <span class="at">TDURDC =</span> <span class="st">"Overall duration (days)"</span></span>
+<span id="cb14-131"><a href="#cb14-131"></a>  )</span>
+<span id="cb14-132"><a href="#cb14-132"></a></span>
+<span id="cb14-133"><a href="#cb14-133"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-134"><a href="#cb14-134"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-135"><a href="#cb14-135"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-136"><a href="#cb14-136"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-137"><a href="#cb14-137"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>),</span>
+<span id="cb14-138"><a href="#cb14-138"></a>    <span class="at">var_labels =</span> <span class="fu">var_labels</span>(anl)[<span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)]</span>
+<span id="cb14-139"><a href="#cb14-139"></a>  )</span>
+<span id="cb14-140"><a href="#cb14-140"></a></span>
+<span id="cb14-141"><a href="#cb14-141"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb14-142"><a href="#cb14-142"></a></span>
+<span id="cb14-143"><a href="#cb14-143"></a>result</span>
+<span id="cb14-144"><a href="#cb14-144"></a><span class="in">```</span></span>
+<span id="cb14-145"><a href="#cb14-145"></a></span>
+<span id="cb14-146"><a href="#cb14-146"></a><span class="fu">## Table with User-Specified &lt;br/&gt; Categories for Missed Doses</span></span>
+<span id="cb14-147"><a href="#cb14-147"></a></span>
+<span id="cb14-148"><a href="#cb14-148"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb14-149"><a href="#cb14-149"></a><span class="co"># When summary table contains both categorical and numeric parameters,</span></span>
+<span id="cb14-150"><a href="#cb14-150"></a><span class="co"># developer needs to do pre-processing to transform dataset to wide format.</span></span>
+<span id="cb14-151"><a href="#cb14-151"></a>adex_avalc_wide <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-152"><a href="#cb14-152"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-153"><a href="#cb14-153"></a>  <span class="fu">select</span>(STUDYID, USUBJID, PARAMCD, AVALC, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-154"><a href="#cb14-154"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb14-155"><a href="#cb14-155"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, PARCAT2),</span>
+<span id="cb14-156"><a href="#cb14-156"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb14-157"><a href="#cb14-157"></a>    <span class="at">values_from =</span> AVALC</span>
+<span id="cb14-158"><a href="#cb14-158"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-159"><a href="#cb14-159"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-160"><a href="#cb14-160"></a>    <span class="at">TDURDC =</span> <span class="fu">factor</span>(TDURD, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"0 - 30"</span>, <span class="st">"31 - 60"</span>, <span class="st">"61 - 90"</span>, <span class="st">"&gt;= 91"</span>))</span>
+<span id="cb14-161"><a href="#cb14-161"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-162"><a href="#cb14-162"></a>  <span class="fu">select</span>(<span class="sc">-</span>TDURD)</span>
+<span id="cb14-163"><a href="#cb14-163"></a></span>
+<span id="cb14-164"><a href="#cb14-164"></a>anl <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-165"><a href="#cb14-165"></a>  <span class="fu">select</span>(STUDYID, USUBJID, ACTARM, PARAMCD, AVAL, PARCAT2) <span class="sc">%&gt;%</span></span>
+<span id="cb14-166"><a href="#cb14-166"></a>  tidyr<span class="sc">::</span><span class="fu">pivot_wider</span>(</span>
+<span id="cb14-167"><a href="#cb14-167"></a>    <span class="at">id_cols =</span> <span class="fu">c</span>(STUDYID, USUBJID, ACTARM, PARCAT2),</span>
+<span id="cb14-168"><a href="#cb14-168"></a>    <span class="at">names_from =</span> PARAMCD,</span>
+<span id="cb14-169"><a href="#cb14-169"></a>    <span class="at">values_from =</span> AVAL</span>
+<span id="cb14-170"><a href="#cb14-170"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-171"><a href="#cb14-171"></a>  <span class="fu">left_join</span>(adex_avalc_wide, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARCAT2"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb14-172"><a href="#cb14-172"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb14-173"><a href="#cb14-173"></a>    <span class="at">TDOSE =</span> <span class="st">"Total dose administered"</span>,</span>
+<span id="cb14-174"><a href="#cb14-174"></a>    <span class="at">TNDOSE =</span> <span class="st">"Total number of doses administered"</span>,</span>
+<span id="cb14-175"><a href="#cb14-175"></a>    <span class="at">TDURD =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb14-176"><a href="#cb14-176"></a>    <span class="at">TNDOSMIS =</span> <span class="st">"Total number of missed doses during study"</span>,</span>
+<span id="cb14-177"><a href="#cb14-177"></a>    <span class="at">TDURDC =</span> <span class="st">"Overall duration (days)"</span></span>
+<span id="cb14-178"><a href="#cb14-178"></a>  )</span>
+<span id="cb14-179"><a href="#cb14-179"></a></span>
+<span id="cb14-180"><a href="#cb14-180"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-181"><a href="#cb14-181"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-182"><a href="#cb14-182"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT2"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n</span><span class="st">Parameter Category (Drug A/Drug B)"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-183"><a href="#cb14-183"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb14-184"><a href="#cb14-184"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>),</span>
+<span id="cb14-185"><a href="#cb14-185"></a>    <span class="at">var_labels =</span> <span class="fu">var_labels</span>(anl)[<span class="fu">c</span>(<span class="st">"TDURD"</span>, <span class="st">"TDURDC"</span>, <span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)]</span>
+<span id="cb14-186"><a href="#cb14-186"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-187"><a href="#cb14-187"></a>  <span class="fu">count_missed_doses</span>(</span>
+<span id="cb14-188"><a href="#cb14-188"></a>    <span class="st">"TNDOSMIS"</span>,</span>
+<span id="cb14-189"><a href="#cb14-189"></a>    <span class="at">thresholds =</span> <span class="fu">c</span>(<span class="dv">1</span>, <span class="dv">5</span>, <span class="dv">10</span>, <span class="dv">15</span>),</span>
+<span id="cb14-190"><a href="#cb14-190"></a>    <span class="at">var_labels =</span> <span class="st">"Missed Doses"</span></span>
+<span id="cb14-191"><a href="#cb14-191"></a>  )</span>
+<span id="cb14-192"><a href="#cb14-192"></a></span>
+<span id="cb14-193"><a href="#cb14-193"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb14-194"><a href="#cb14-194"></a></span>
+<span id="cb14-195"><a href="#cb14-195"></a>result</span>
+<span id="cb14-196"><a href="#cb14-196"></a><span class="in">```</span></span>
+<span id="cb14-197"><a href="#cb14-197"></a></span>
+<span id="cb14-198"><a href="#cb14-198"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-199"><a href="#cb14-199"></a></span>
+<span id="cb14-200"><a href="#cb14-200"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-201"><a href="#cb14-201"></a></span>
+<span id="cb14-202"><a href="#cb14-202"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-203"><a href="#cb14-203"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb14-204"><a href="#cb14-204"></a></span>
+<span id="cb14-205"><a href="#cb14-205"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-206"><a href="#cb14-206"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-207"><a href="#cb14-207"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-208"><a href="#cb14-208"></a></span>
+<span id="cb14-209"><a href="#cb14-209"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-210"><a href="#cb14-210"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb14-211"><a href="#cb14-211"></a>adex_labels <span class="ot">&lt;-</span> <span class="fu">unname</span>(<span class="fu">var_labels</span>(adex))</span>
+<span id="cb14-212"><a href="#cb14-212"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb14-213"><a href="#cb14-213"></a>  <span class="fu">filter</span>(PARCAT1 <span class="sc">==</span> <span class="st">"OVERALL"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-214"><a href="#cb14-214"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb14-215"><a href="#cb14-215"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">case_when</span>(</span>
+<span id="cb14-216"><a href="#cb14-216"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> <span class="dv">5000</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb14-217"><a href="#cb14-217"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> <span class="dv">5000</span> <span class="sc">~</span> <span class="st">"HIGH"</span>,</span>
+<span id="cb14-218"><a href="#cb14-218"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"&lt; 10"</span>,</span>
+<span id="cb14-219"><a href="#cb14-219"></a>      PARAMCD <span class="sc">==</span> <span class="st">"TNDOSE"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> <span class="dv">10</span> <span class="sc">~</span> <span class="st">"&gt;= 10"</span></span>
+<span id="cb14-220"><a href="#cb14-220"></a>    )</span>
+<span id="cb14-221"><a href="#cb14-221"></a>  )</span>
+<span id="cb14-222"><a href="#cb14-222"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(adex_labels, <span class="st">""</span>)</span>
+<span id="cb14-223"><a href="#cb14-223"></a></span>
+<span id="cb14-224"><a href="#cb14-224"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb14-225"><a href="#cb14-225"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-226"><a href="#cb14-226"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-227"><a href="#cb14-227"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb14-228"><a href="#cb14-228"></a>      adsl,</span>
+<span id="cb14-229"><a href="#cb14-229"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb14-230"><a href="#cb14-230"></a>    ),</span>
+<span id="cb14-231"><a href="#cb14-231"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-232"><a href="#cb14-232"></a>      <span class="st">"ADEX"</span>,</span>
+<span id="cb14-233"><a href="#cb14-233"></a>      adex,</span>
+<span id="cb14-234"><a href="#cb14-234"></a>      <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb14-235"><a href="#cb14-235"></a><span class="st">      ADEX_labels &lt;- unname(var_labels(ADEX))</span></span>
+<span id="cb14-236"><a href="#cb14-236"></a><span class="st">      ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb14-237"><a href="#cb14-237"></a><span class="st">        filter(PARCAT1 == "OVERALL") %&gt;%</span></span>
+<span id="cb14-238"><a href="#cb14-238"></a><span class="st">        mutate(</span></span>
+<span id="cb14-239"><a href="#cb14-239"></a><span class="st">          AVALCAT1 = case_when(</span></span>
+<span id="cb14-240"><a href="#cb14-240"></a><span class="st">            PARAMCD == "TDOSE" &amp;  AVAL &lt; 5000 ~  "LOW",</span></span>
+<span id="cb14-241"><a href="#cb14-241"></a><span class="st">            PARAMCD == "TDOSE" &amp;  AVAL &gt;= 5000 ~ "HIGH",</span></span>
+<span id="cb14-242"><a href="#cb14-242"></a><span class="st">            PARAMCD == "TNDOSE" &amp;  AVAL &lt; 10 ~  "&lt; 10",</span></span>
+<span id="cb14-243"><a href="#cb14-243"></a><span class="st">            PARAMCD == "TNDOSE" &amp;  AVAL &gt;= 10 ~  "&gt;= 10")</span></span>
+<span id="cb14-244"><a href="#cb14-244"></a><span class="st">        )</span></span>
+<span id="cb14-245"><a href="#cb14-245"></a><span class="st">      var_labels(ADEX) &lt;- c(ADEX_labels, "")'</span></span>
+<span id="cb14-246"><a href="#cb14-246"></a>    ),</span>
+<span id="cb14-247"><a href="#cb14-247"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-248"><a href="#cb14-248"></a>  ),</span>
+<span id="cb14-249"><a href="#cb14-249"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-250"><a href="#cb14-250"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb14-251"><a href="#cb14-251"></a>      <span class="at">label =</span> <span class="st">"Exposure Table"</span>,</span>
+<span id="cb14-252"><a href="#cb14-252"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb14-253"><a href="#cb14-253"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-254"><a href="#cb14-254"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb14-255"><a href="#cb14-255"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb14-256"><a href="#cb14-256"></a>      ),</span>
+<span id="cb14-257"><a href="#cb14-257"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-258"><a href="#cb14-258"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"PARCAT2"</span>, <span class="st">"PARAM"</span>)),</span>
+<span id="cb14-259"><a href="#cb14-259"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARCAT2"</span>, <span class="st">"PARAM"</span>)</span>
+<span id="cb14-260"><a href="#cb14-260"></a>      ),</span>
+<span id="cb14-261"><a href="#cb14-261"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-262"><a href="#cb14-262"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"AVALCAT1"</span>)),</span>
+<span id="cb14-263"><a href="#cb14-263"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"AVALCAT1"</span>)</span>
+<span id="cb14-264"><a href="#cb14-264"></a>      ),</span>
+<span id="cb14-265"><a href="#cb14-265"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-266"><a href="#cb14-266"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb14-267"><a href="#cb14-267"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"TDOSE"</span>, <span class="st">"TNDOSE"</span>)</span>
+<span id="cb14-268"><a href="#cb14-268"></a>      ),</span>
+<span id="cb14-269"><a href="#cb14-269"></a>      <span class="at">denominator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-270"><a href="#cb14-270"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"N"</span>, <span class="st">"omit"</span>),</span>
+<span id="cb14-271"><a href="#cb14-271"></a>        <span class="at">selected =</span> <span class="st">"N"</span></span>
+<span id="cb14-272"><a href="#cb14-272"></a>      )</span>
+<span id="cb14-273"><a href="#cb14-273"></a>    )</span>
+<span id="cb14-274"><a href="#cb14-274"></a>  ), <span class="co"># Set initial filter state as single study drug to produce smaller table</span></span>
+<span id="cb14-275"><a href="#cb14-275"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADEX =</span> <span class="fu">list</span>(<span class="at">PARCAT2 =</span> <span class="st">"Drug A"</span>, <span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb14-276"><a href="#cb14-276"></a>)</span>
+<span id="cb14-277"><a href="#cb14-277"></a></span>
+<span id="cb14-278"><a href="#cb14-278"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-279"><a href="#cb14-279"></a><span class="in">```</span></span>
+<span id="cb14-280"><a href="#cb14-280"></a></span>
+<span id="cb14-281"><a href="#cb14-281"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-282"><a href="#cb14-282"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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new file mode 100644
index 0000000000..da7cf73667
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+            <i class="bi bi-chevron-right ms-2"></i>
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+ <span class="menu-text">ADAT01</span></a>
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+</li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
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+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
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+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
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+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+    </ul>
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results and Change from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>In order to generate the <code>LBT01</code> standard tabulation, the <code>adlb</code> dataset may be pre-processed so as to discriminate baseline from follow-up visits.</p>
+<div class="cell" data-hash="lbt01_cache/html/setup_258f4f18bac409dca1b2192fa0f64075">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb) <span class="sc">%&gt;%</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># For illustration purpose, the example focuses on "Alanine Aminotransferase</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="co"># Measurement" starting from baseline, while excluding visit at week 1 for</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># subjects who were prescribed a placebo.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    PARAM <span class="sc">==</span> <span class="st">"Alanine Aminotransferase Measurement"</span> <span class="sc">&amp;</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="sc">!</span>(ACTARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">&amp;</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>      AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt01_cache/html/variant1_ff811f888710fda869ea0ed520591dba">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  } <span class="cf">else</span> {</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  }</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  )</span>
+<span id="cb2-27"><a href="#cb2-27"></a>}</span>
+<span id="cb2-28"><a href="#cb2-28"></a></span>
+<span id="cb2-29"><a href="#cb2-29"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb2-38"><a href="#cb2-38"></a></span>
+<span id="cb2-39"><a href="#cb2-39"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb_f)</span>
+<span id="cb2-40"><a href="#cb2-40"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                         A: Drug X                        B: Placebo                      C: Combination         
+  Analysis Visit                                         Change from                       Change from                       Change from  
+                                       Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   
+                                          (N=804)          (N=804)          (N=670)          (N=670)          (N=792)          (N=792)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                                                                      
+  BASELINE                                                                                                                                
+    n                                       134                               134                               132                       
+    Mean (SD)                           17.74 (9.93)                      18.71 (9.83)                      19.46 (9.08)                  
+    Median                                 17.46                             18.19                             18.97                      
+    Min - Max                           0.00 - 44.06                      1.48 - 54.40                      0.57 - 39.81                  
+  WEEK 1 DAY 8                                                                                                                            
+    n                                       134              134               0                0               132              132      
+    Mean (SD)                           16.75 (9.08)    -0.99 (13.49)       NE (NE)          NE (NE)        19.61 (9.27)     0.14 (12.85) 
+    Median                                 16.02            -1.28              NE               NE             19.00             0.06     
+    Min - Max                           0.05 - 36.30    -31.31 - 27.89      NE - NE          NE - NE        0.91 - 44.75    -32.45 - 38.85
+  WEEK 2 DAY 15                                                                                                                           
+    n                                       134              134              134              134              132              132      
+    Mean (SD)                           17.82 (9.60)     0.08 (14.15)     18.82 (9.73)     0.11 (14.45)     16.55 (8.15)    -2.92 (12.64) 
+    Median                                 15.92             0.28            17.96            -0.93            17.02            -1.11     
+    Min - Max                           0.40 - 44.33    -32.89 - 40.55    0.18 - 44.34    -45.93 - 29.85    0.35 - 34.69    -28.36 - 23.98
+  WEEK 3 DAY 22                                                                                                                           
+    n                                       134              134              134              134              132              132      
+    Mean (SD)                           18.37 (9.30)     0.63 (13.85)     17.65 (9.58)    -1.06 (13.58)     16.75 (9.54)    -2.71 (13.22) 
+    Median                                 18.11             1.13            17.68            -0.49            15.10            -2.66     
+    Min - Max                           0.59 - 41.73    -40.09 - 31.24    0.02 - 38.61    -46.30 - 31.38    0.48 - 39.23    -30.63 - 26.51
+  WEEK 4 DAY 29                                                                                                                           
+    n                                       134              134              134              134              132              132      
+    Mean (SD)                          19.17 (10.95)     1.44 (15.39)    17.22 (10.64)    -1.48 (15.20)     17.92 (9.32)    -1.54 (12.63) 
+    Median                                 17.41             0.88            15.88            -2.96            17.71            -1.53     
+    Min - Max                           0.93 - 54.24    -32.93 - 46.98    0.39 - 47.96    -41.45 - 43.08    0.25 - 41.27    -30.33 - 27.99
+  WEEK 5 DAY 36                                                                                                                           
+    n                                       134              134              134              134              132              132      
+    Mean (SD)                           19.22 (9.47)     1.48 (14.49)     18.01 (9.92)    -0.69 (14.65)     18.51 (9.43)    -0.95 (12.92) 
+    Median                                 19.80             2.31            18.28             1.82            19.26            -2.48     
+    Min - Max                           0.01 - 43.42    -40.08 - 30.07    0.11 - 40.64    -47.60 - 26.04    0.02 - 37.46    -29.78 - 25.00</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:18}" data-hash="lbt01_cache/html/teal_b6b046dafcd1534984ed47220f7a297c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>      adsl,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>    ),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      adlb,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adlb"))'</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>    ),</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a>  ),</span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-29"><a href="#cb4-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-30"><a href="#cb4-30"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>      ),</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-33"><a href="#cb4-33"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      ),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-37"><a href="#cb4-37"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb4-38"><a href="#cb4-38"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb4-39"><a href="#cb4-39"></a>      ),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>      ),</span>
+<span id="cb4-45"><a href="#cb4-45"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-46"><a href="#cb4-46"></a>    )</span>
+<span id="cb4-47"><a href="#cb4-47"></a>  ),</span>
+<span id="cb4-48"><a href="#cb4-48"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb4-49"><a href="#cb4-49"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:31:47.3601 pid:12934 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt01_cache/html/sessioninfo_01d007b08a090a8c34ca01f7df45d07e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt01_cache/html/snapshot_b58698014e3fa1d0fd461b50691322e4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
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+          selectedAnnoteEl = annoteEl;
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+          if (div) {
+            div.remove();
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+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
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+            clickedEl.classList.add('code-annotation-active');
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+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
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+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt02.html" class="pagination-link">
+        <span class="nav-page-text">LBT02</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results and Change from Baseline by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a>In order to generate the <span class="in">`LBT01`</span> standard tabulation, the <span class="in">`adlb`</span> dataset may be pre-processed so as to discriminate baseline from follow-up visits.</span>
+<span id="cb10-14"><a href="#cb10-14"></a></span>
+<span id="cb10-15"><a href="#cb10-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a></span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-20"><a href="#cb10-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-21"><a href="#cb10-21"></a></span>
+<span id="cb10-22"><a href="#cb10-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-23"><a href="#cb10-23"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-27"><a href="#cb10-27"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb) <span class="sc">%&gt;%</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="fu">filter</span>(ANL01FL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="co"># For illustration purpose, the example focuses on "Alanine Aminotransferase</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a><span class="co"># Measurement" starting from baseline, while excluding visit at week 1 for</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a><span class="co"># subjects who were prescribed a placebo.</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    PARAM <span class="sc">==</span> <span class="st">"Alanine Aminotransferase Measurement"</span> <span class="sc">&amp;</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>      <span class="sc">!</span>(ACTARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>) <span class="sc">&amp;</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>      AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>  )</span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="in">```</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a></span>
+<span id="cb10-41"><a href="#cb10-41"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a></span>
+<span id="cb10-43"><a href="#cb10-43"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="co"># Define the split function</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-46"><a href="#cb10-46"></a></span>
+<span id="cb10-47"><a href="#cb10-47"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb10-48"><a href="#cb10-48"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-51"><a href="#cb10-51"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  } <span class="cf">else</span> {</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb10-55"><a href="#cb10-55"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-56"><a href="#cb10-56"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb10-57"><a href="#cb10-57"></a>  }</span>
+<span id="cb10-58"><a href="#cb10-58"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb10-61"><a href="#cb10-61"></a></span>
+<span id="cb10-62"><a href="#cb10-62"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb10-63"><a href="#cb10-63"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb10-65"><a href="#cb10-65"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb10-66"><a href="#cb10-66"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb10-67"><a href="#cb10-67"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb10-68"><a href="#cb10-68"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb10-69"><a href="#cb10-69"></a>  )</span>
+<span id="cb10-70"><a href="#cb10-70"></a>}</span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb10-77"><a href="#cb10-77"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb10-79"><a href="#cb10-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb10-81"><a href="#cb10-81"></a></span>
+<span id="cb10-82"><a href="#cb10-82"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb_f)</span>
+<span id="cb10-83"><a href="#cb10-83"></a>result</span>
+<span id="cb10-84"><a href="#cb10-84"></a><span class="in">```</span></span>
+<span id="cb10-85"><a href="#cb10-85"></a></span>
+<span id="cb10-86"><a href="#cb10-86"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-87"><a href="#cb10-87"></a></span>
+<span id="cb10-88"><a href="#cb10-88"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-89"><a href="#cb10-89"></a></span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-91"><a href="#cb10-91"></a><span class="co">#| screenshot.opts = list(delay = 18)</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a></span>
+<span id="cb10-93"><a href="#cb10-93"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-94"><a href="#cb10-94"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-95"><a href="#cb10-95"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-96"><a href="#cb10-96"></a></span>
+<span id="cb10-97"><a href="#cb10-97"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-98"><a href="#cb10-98"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-102"><a href="#cb10-102"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-103"><a href="#cb10-103"></a></span>
+<span id="cb10-104"><a href="#cb10-104"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-105"><a href="#cb10-105"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-106"><a href="#cb10-106"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb10-107"><a href="#cb10-107"></a>      adsl,</span>
+<span id="cb10-108"><a href="#cb10-108"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a>    ),</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>,</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      adlb,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adlb"))'</span></span>
+<span id="cb10-113"><a href="#cb10-113"></a>    ),</span>
+<span id="cb10-114"><a href="#cb10-114"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>  ),</span>
+<span id="cb10-116"><a href="#cb10-116"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-117"><a href="#cb10-117"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-118"><a href="#cb10-118"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb10-119"><a href="#cb10-119"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb10-120"><a href="#cb10-120"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-121"><a href="#cb10-121"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-122"><a href="#cb10-122"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-123"><a href="#cb10-123"></a>      ),</span>
+<span id="cb10-124"><a href="#cb10-124"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-125"><a href="#cb10-125"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-126"><a href="#cb10-126"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>)</span>
+<span id="cb10-127"><a href="#cb10-127"></a>      ),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-129"><a href="#cb10-129"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb10-131"><a href="#cb10-131"></a>      ),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-133"><a href="#cb10-133"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-134"><a href="#cb10-134"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-135"><a href="#cb10-135"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb10-136"><a href="#cb10-136"></a>      ),</span>
+<span id="cb10-137"><a href="#cb10-137"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-138"><a href="#cb10-138"></a>    )</span>
+<span id="cb10-139"><a href="#cb10-139"></a>  ),</span>
+<span id="cb10-140"><a href="#cb10-140"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb10-141"><a href="#cb10-141"></a>)</span>
+<span id="cb10-142"><a href="#cb10-142"></a></span>
+<span id="cb10-143"><a href="#cb10-143"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-144"><a href="#cb10-144"></a><span class="in">```</span></span>
+<span id="cb10-145"><a href="#cb10-145"></a></span>
+<span id="cb10-146"><a href="#cb10-146"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-147"><a href="#cb10-147"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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new file mode 100644
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--- /dev/null
+++ b/stable/tables/lab-results/lbt02.html
@@ -0,0 +1,2216 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT02</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
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+/* CSS for syntax highlighting */
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
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+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
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+  { counter-reset: source-line 0; }
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/lab-results/lbt03.html" rel="next">
+<link href="../../tables/lab-results/lbt01.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="../../site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
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+  "copy-button": true,
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+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET06</span></a>
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+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt02_cache/html/setup_cc63d4f26e09bb6aa236bc1ecab0a759">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="co"># Preparation of an illustrative dataset</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adlb_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># For illustration purposes, the example focuses on ALT</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Measurements starting from baseline and excluding all screening visits</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adlb <span class="ot">&lt;-</span> <span class="fu">subset</span>(adlb, AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span> <span class="sc">&amp;</span> PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">droplevels</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="fu">var_labels</span>(adlb) <span class="ot">&lt;-</span> adlb_labels</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-19"><a href="#cb1-19"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt02_cache/html/variant1_2e64944e6419ba8057987164016b3ca0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>l <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">var =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>)</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(l,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">df =</span> adlb,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-18"><a href="#cb2-18"></a>)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Analysis Visit    A: Drug X    B: Placebo    C: Combination   All Patients
+                   (N=134)       (N=134)        (N=132)         (N=400)   
+——————————————————————————————————————————————————————————————————————————
+BASELINE                                                                  
+  n                  134           134            132             400     
+  Mean (SD)      17.7 (9.9)    18.7 (9.8)      19.5 (9.1)      18.6 (9.6) 
+  Median            17.5          18.2            19.0            18.0    
+  Min - Max      0.0 - 44.1    1.5 - 54.4      0.6 - 39.8      0.0 - 54.4 
+WEEK 1 DAY 8                                                              
+  n                  134           134            132             400     
+  Mean (SD)      16.8 (9.1)    18.9 (9.2)      19.6 (9.3)      18.4 (9.2) 
+  Median            16.0          18.2            19.0            18.0    
+  Min - Max      0.1 - 36.3    0.7 - 39.9      0.9 - 44.7      0.1 - 44.7 
+WEEK 2 DAY 15                                                             
+  n                  134           134            132             400     
+  Mean (SD)      17.8 (9.6)    18.8 (9.7)      16.5 (8.2)      17.7 (9.2) 
+  Median            15.9          18.0            17.0            17.0    
+  Min - Max      0.4 - 44.3    0.2 - 44.3      0.3 - 34.7      0.2 - 44.3 
+WEEK 3 DAY 22                                                             
+  n                  134           134            132             400     
+  Mean (SD)      18.4 (9.3)    17.6 (9.6)      16.8 (9.5)      17.6 (9.5) 
+  Median            18.1          17.7            15.1            17.2    
+  Min - Max      0.6 - 41.7    0.0 - 38.6      0.5 - 39.2      0.0 - 41.7 
+WEEK 4 DAY 29                                                             
+  n                  134           134            132             400     
+  Mean (SD)      19.2 (11.0)   17.2 (10.6)     17.9 (9.3)     18.1 (10.3) 
+  Median            17.4          15.9            17.7            17.3    
+  Min - Max      0.9 - 54.2    0.4 - 48.0      0.2 - 41.3      0.2 - 54.2 
+WEEK 5 DAY 36                                                             
+  n                  134           134            132             400     
+  Mean (SD)      19.2 (9.5)    18.0 (9.9)      18.5 (9.4)      18.6 (9.6) 
+  Median            19.8          18.3            19.3            19.0    
+  Min - Max      0.0 - 43.4    0.1 - 40.6      0.0 - 37.5      0.0 - 43.4 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="lbt02_cache/html/teal_4313fca33a122e71534c68233b82f035">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a><span class="co"># Ensure missing and NA values are cleaned up and convert variables to factors.</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a><span class="st">                                        ADSL &lt;- df_explicit_na(ADSL)'</span>),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a><span class="st">                                        ADLB &lt;- df_explicit_na(ADLB)'</span>),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>  ),</span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results by Visit"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>      ),</span>
+<span id="cb4-28"><a href="#cb4-28"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-29"><a href="#cb4-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)), <span class="co"># note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)</span>
+<span id="cb4-31"><a href="#cb4-31"></a>      ),</span>
+<span id="cb4-32"><a href="#cb4-32"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-33"><a href="#cb4-33"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>)),</span>
+<span id="cb4-34"><a href="#cb4-34"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>)</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      ),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-39"><a href="#cb4-39"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb4-40"><a href="#cb4-40"></a>      )</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    )</span>
+<span id="cb4-42"><a href="#cb4-42"></a>  ),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb4-44"><a href="#cb4-44"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:32:58.5717 pid:13187 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt02_cache/html/sessioninfo_bf1be9d4e2a15e0933ac89141824c832">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] dplyr_1.1.3                  teal.modules.clinical_0.8.16
+ [3] teal_0.14.0                  teal.transform_0.4.0        
+ [5] teal.slice_0.4.0             teal.data_0.3.0             
+ [7] shiny_1.7.5                  tern_0.9.0                  
+ [9] rtables_0.6.3                magrittr_2.0.3              
+[11] formatters_0.5.2             scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt02_cache/html/snapshot_e5b330dea3b8dc751ed1e0701ec3cba3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
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+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT02</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="co"># Preparation of an illustrative dataset</span></span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adlb_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a><span class="co"># For illustration purposes, the example focuses on ALT</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a><span class="co"># Measurements starting from baseline and excluding all screening visits</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adlb <span class="ot">&lt;-</span> <span class="fu">subset</span>(adlb, AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span> <span class="sc">&amp;</span> PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span>)</span>
+<span id="cb10-28"><a href="#cb10-28"></a>adlb<span class="sc">$</span>AVISIT <span class="ot">&lt;-</span> <span class="fu">droplevels</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="fu">var_labels</span>(adlb) <span class="ot">&lt;-</span> adlb_labels</span>
+<span id="cb10-31"><a href="#cb10-31"></a></span>
+<span id="cb10-32"><a href="#cb10-32"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-34"><a href="#cb10-34"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-35"><a href="#cb10-35"></a><span class="in">```</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a></span>
+<span id="cb10-37"><a href="#cb10-37"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="co"># Define the split function</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-42"><a href="#cb10-42"></a></span>
+<span id="cb10-43"><a href="#cb10-43"></a>l <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">var =</span> <span class="st">"AVISIT"</span>,</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>AVISIT)</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="fu">analyze_vars</span>(<span class="at">vars =</span> <span class="st">"AVAL"</span>)</span>
+<span id="cb10-53"><a href="#cb10-53"></a></span>
+<span id="cb10-54"><a href="#cb10-54"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(l,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="at">df =</span> adlb,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-57"><a href="#cb10-57"></a>)</span>
+<span id="cb10-58"><a href="#cb10-58"></a>result</span>
+<span id="cb10-59"><a href="#cb10-59"></a><span class="in">```</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a></span>
+<span id="cb10-61"><a href="#cb10-61"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-62"><a href="#cb10-62"></a></span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-69"><a href="#cb10-69"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-73"><a href="#cb10-73"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="co"># Ensure missing and NA values are cleaned up and convert variables to factors.</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-77"><a href="#cb10-77"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-78"><a href="#cb10-78"></a></span>
+<span id="cb10-79"><a href="#cb10-79"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb10-82"><a href="#cb10-82"></a><span class="st">                                        ADSL &lt;- df_explicit_na(ADSL)'</span>),</span>
+<span id="cb10-83"><a href="#cb10-83"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a><span class="st">                                        ADLB &lt;- df_explicit_na(ADLB)'</span>),</span>
+<span id="cb10-85"><a href="#cb10-85"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a>  ),</span>
+<span id="cb10-87"><a href="#cb10-87"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-88"><a href="#cb10-88"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-89"><a href="#cb10-89"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results by Visit"</span>,</span>
+<span id="cb10-90"><a href="#cb10-90"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb10-91"><a href="#cb10-91"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-92"><a href="#cb10-92"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-93"><a href="#cb10-93"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-94"><a href="#cb10-94"></a>      ),</span>
+<span id="cb10-95"><a href="#cb10-95"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-96"><a href="#cb10-96"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)), <span class="co"># note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)</span>
+<span id="cb10-98"><a href="#cb10-98"></a>      ),</span>
+<span id="cb10-99"><a href="#cb10-99"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-100"><a href="#cb10-100"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>)),</span>
+<span id="cb10-101"><a href="#cb10-101"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>)</span>
+<span id="cb10-102"><a href="#cb10-102"></a>      ),</span>
+<span id="cb10-103"><a href="#cb10-103"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-104"><a href="#cb10-104"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-105"><a href="#cb10-105"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-106"><a href="#cb10-106"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb10-107"><a href="#cb10-107"></a>      )</span>
+<span id="cb10-108"><a href="#cb10-108"></a>    )</span>
+<span id="cb10-109"><a href="#cb10-109"></a>  ),</span>
+<span id="cb10-110"><a href="#cb10-110"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb10-111"><a href="#cb10-111"></a>)</span>
+<span id="cb10-112"><a href="#cb10-112"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-113"><a href="#cb10-113"></a><span class="in">```</span></span>
+<span id="cb10-114"><a href="#cb10-114"></a></span>
+<span id="cb10-115"><a href="#cb10-115"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-116"><a href="#cb10-116"></a></span>
+<span id="cb10-117"><a href="#cb10-117"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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new file mode 100644
index 0000000000..b2f6ca4d9f
--- /dev/null
+++ b/stable/tables/lab-results/lbt03.html
@@ -0,0 +1,2441 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT03</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/lab-results/lbt04.html" rel="next">
+<link href="../../tables/lab-results/lbt02.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="../../site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="../../site_libs/quarto-html/quarto.js"></script>
+<script src="../../site_libs/quarto-html/popper.min.js"></script>
+<script src="../../site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results Change from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>For illustration purposes, this example focuses on “C-Reactive Protein Measurement” starting from baseline, while excluding visit at week 1 for subjects who were randomized to the placebo group.</p>
+<div class="cell" data-hash="lbt03_cache/html/setup_2b1f716e24a051a49b31abbfbc510960">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>saved_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    PARAM <span class="sc">==</span> <span class="st">"C-Reactive Protein Measurement"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="sc">!</span>(ARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>      AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">ABLFLL =</span> ABLFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  )</span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a><span class="fu">var_labels</span>(adlb_f) <span class="ot">&lt;-</span> <span class="fu">c</span>(saved_labels, <span class="st">""</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>The <code>LBT03</code> template is the result of a junction between the analysis of <code>AVAL</code> at baseline and <code>CHG</code> at visit time. <code>AVAL</code> is summarized for baseline visits and and <code>CHG</code> is summarized for post-baseline visits.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt03_cache/html/variant1_0974b3aa654a433fb6830a08172a8ff2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">summarize_change</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"CHG"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">value =</span> <span class="st">"AVAL"</span>, <span class="at">baseline_flag =</span> <span class="st">"ABLFLL"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">na.rm =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  )</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-17"><a href="#cb2-17"></a>)</span>
+<span id="cb2-18"><a href="#cb2-18"></a></span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Analysis Visit    A: Drug X      B: Placebo    C: Combination
+                   (N=134)        (N=134)         (N=132)    
+—————————————————————————————————————————————————————————————
+BASELINE                                                     
+  n                  134            134             132      
+  Mean (SD)      9.06 (0.93)    8.99 (0.98)     8.98 (0.89)  
+  Median             9.07           8.92            8.96     
+  Min - Max      6.21 - 11.87   6.23 - 11.63    6.24 - 11.18 
+WEEK 1 DAY 8                                                 
+  n                  134             0              132      
+  Mean (SD)      -0.05 (1.38)        NA         -0.02 (1.30) 
+  Median            -0.17            NA             0.02     
+  Min - Max      -3.56 - 3.48        NA         -3.28 - 3.33 
+WEEK 2 DAY 15                                                
+  n                  134            134             132      
+  Mean (SD)      -0.19 (1.47)   0.01 (1.45)     0.15 (1.25)  
+  Median            -0.27          -0.00            0.15     
+  Min - Max      -4.53 - 4.45   -3.79 - 3.43    -2.92 - 3.28 
+WEEK 3 DAY 22                                                
+  n                  134            134             132      
+  Mean (SD)      0.03 (1.38)    -0.02 (1.49)    0.02 (1.34)  
+  Median             0.15          -0.04            0.20     
+  Min - Max      -3.95 - 2.99   -4.28 - 4.24    -2.76 - 3.26 
+WEEK 4 DAY 29                                                
+  n                  134            134             132      
+  Mean (SD)      -0.26 (1.45)   0.05 (1.24)     -0.01 (1.17) 
+  Median            -0.37           0.10           -0.06     
+  Min - Max      -3.74 - 4.15   -3.34 - 3.71    -3.06 - 3.22 
+WEEK 5 DAY 36                                                
+  n                  134            134             132      
+  Mean (SD)      -0.02 (1.50)   0.07 (1.34)     0.03 (1.27)  
+  Median             0.01           0.15            0.05     
+  Min - Max      -4.15 - 3.96   -3.50 - 3.53    -3.63 - 4.78 </code></pre>
+</div>
+</div>
+<p>In the final step, a new variable is derived from <code>AVISIT</code> that can specify the method of estimation of the evaluated change.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt03_cache/html/variant2_4e3a3ba99c5f0b644cc70cef2ea458a3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>adlb_f <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">AVISIT_header =</span> <span class="fu">recode</span>(AVISIT,</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="st">"BASELINE"</span> <span class="ot">=</span> <span class="st">"BASELINE"</span>,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="st">"WEEK 1 DAY 8"</span> <span class="ot">=</span> <span class="st">"WEEK 1 DAY 8 value minus baseline"</span>,</span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="st">"WEEK 2 DAY 15"</span> <span class="ot">=</span> <span class="st">"WEEK 2 DAY 15 value minus baseline"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="st">"WEEK 3 DAY 22"</span> <span class="ot">=</span> <span class="st">"WEEK 3 DAY 22 value minus baseline"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="st">"WEEK 4 DAY 29"</span> <span class="ot">=</span> <span class="st">"WEEK 4 DAY 29 value minus baseline"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="st">"WEEK 5 DAY 36"</span> <span class="ot">=</span> <span class="st">"WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>))</span>
+<span id="cb4-9"><a href="#cb4-9"></a></span>
+<span id="cb4-10"><a href="#cb4-10"></a><span class="co"># Define the split function</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT_header"</span>,</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="fu">summarize_change</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="st">"CHG"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">value =</span> <span class="st">"AVAL"</span>, <span class="at">baseline_flag =</span> <span class="st">"ABLFLL"</span>),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">na.rm =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  )</span>
+<span id="cb4-25"><a href="#cb4-25"></a></span>
+<span id="cb4-26"><a href="#cb4-26"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-30"><a href="#cb4-30"></a>)</span>
+<span id="cb4-31"><a href="#cb4-31"></a></span>
+<span id="cb4-32"><a href="#cb4-32"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Analysis Visit                        A: Drug X      B: Placebo    C: Combination
+                                       (N=134)        (N=134)         (N=132)    
+—————————————————————————————————————————————————————————————————————————————————
+BASELINE                                                                         
+  n                                      134            134             132      
+  Mean (SD)                          9.06 (0.93)    8.99 (0.98)     8.98 (0.89)  
+  Median                                 9.07           8.92            8.96     
+  Min - Max                          6.21 - 11.87   6.23 - 11.63    6.24 - 11.18 
+WEEK 1 DAY 8 value minus baseline                                                
+  n                                      134             0              132      
+  Mean (SD)                          -0.05 (1.38)        NA         -0.02 (1.30) 
+  Median                                -0.17            NA             0.02     
+  Min - Max                          -3.56 - 3.48        NA         -3.28 - 3.33 
+WEEK 2 DAY 15 value minus baseline                                               
+  n                                      134            134             132      
+  Mean (SD)                          -0.19 (1.47)   0.01 (1.45)     0.15 (1.25)  
+  Median                                -0.27          -0.00            0.15     
+  Min - Max                          -4.53 - 4.45   -3.79 - 3.43    -2.92 - 3.28 
+WEEK 3 DAY 22 value minus baseline                                               
+  n                                      134            134             132      
+  Mean (SD)                          0.03 (1.38)    -0.02 (1.49)    0.02 (1.34)  
+  Median                                 0.15          -0.04            0.20     
+  Min - Max                          -3.95 - 2.99   -4.28 - 4.24    -2.76 - 3.26 
+WEEK 4 DAY 29 value minus baseline                                               
+  n                                      134            134             132      
+  Mean (SD)                          -0.26 (1.45)   0.05 (1.24)     -0.01 (1.17) 
+  Median                                -0.37           0.10           -0.06     
+  Min - Max                          -3.74 - 4.15   -3.34 - 3.71    -3.06 - 3.22 
+WEEK 5 DAY 36 value minus baseline                                               
+  n                                      134            134             132      
+  Mean (SD)                          -0.02 (1.50)   0.07 (1.34)     0.03 (1.27)  
+  Median                                 0.01           0.15            0.05     
+  Min - Max                          -4.15 - 3.96   -3.50 - 3.53    -3.63 - 4.78 </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Here, we pre-process and manually define the variable “Baseline or Absolute Change from Baseline”.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="lbt03_cache/html/teal_a5361243903e8a2fa811d3c4fe8ae94e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(<span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>))</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(<span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">filter</span>(</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="sc">!</span>(ARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">ABLFLL =</span> ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">AVISIT_header =</span> <span class="fu">recode</span>(AVISIT,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>      <span class="st">"BASELINE"</span> <span class="ot">=</span> <span class="st">"BASELINE"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="st">"WEEK 1 DAY 8"</span> <span class="ot">=</span> <span class="st">"WEEK 1 DAY 8 value minus baseline"</span>,</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      <span class="st">"WEEK 2 DAY 15"</span> <span class="ot">=</span> <span class="st">"WEEK 2 DAY 15 value minus baseline"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>      <span class="st">"WEEK 3 DAY 22"</span> <span class="ot">=</span> <span class="st">"WEEK 3 DAY 22 value minus baseline"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>      <span class="st">"WEEK 4 DAY 29"</span> <span class="ot">=</span> <span class="st">"WEEK 4 DAY 29 value minus baseline"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>      <span class="st">"WEEK 5 DAY 36"</span> <span class="ot">=</span> <span class="st">"WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>    )</span>
+<span id="cb6-22"><a href="#cb6-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(USUBJID, PARAM) <span class="sc">%&gt;%</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>    <span class="at">AVAL_CHG =</span> AVAL <span class="sc">-</span> (<span class="sc">!</span>ABLFLL) <span class="sc">*</span> <span class="fu">sum</span>(AVAL <span class="sc">*</span> ABLFLL)</span>
+<span id="cb6-26"><a href="#cb6-26"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-27"><a href="#cb6-27"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">AVAL_CHG =</span> <span class="st">"Baseline or Absolute Change from Baseline"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="at">ABLFLL =</span> <span class="st">"Baseline Flag (TRUE/FALSE)"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">AVISIT_header =</span> <span class="st">"Analysis Visit"</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>  )</span>
+<span id="cb6-33"><a href="#cb6-33"></a></span>
+<span id="cb6-34"><a href="#cb6-34"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-35"><a href="#cb6-35"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a><span class="st">                  ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adlb")) %&gt;%</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a><span class="st">                  filter(</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a><span class="st">                    !(ARM == "B: Placebo" &amp; AVISIT == "WEEK 1 DAY 8"),</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a><span class="st">                    AVISIT != "SCREENING"</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a><span class="st">                  dplyr::mutate(</span></span>
+<span id="cb6-44"><a href="#cb6-44"></a><span class="st">                    AVISIT = droplevels(AVISIT),</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a><span class="st">                    ABLFLL = ABLFL == "Y",</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a><span class="st">                    AVISIT_header = recode(AVISIT,</span></span>
+<span id="cb6-47"><a href="#cb6-47"></a><span class="st">                           "BASELINE" = "BASELINE",</span></span>
+<span id="cb6-48"><a href="#cb6-48"></a><span class="st">                           "WEEK 1 DAY 8" = "WEEK 1 DAY 8 value minus baseline",</span></span>
+<span id="cb6-49"><a href="#cb6-49"></a><span class="st">                           "WEEK 2 DAY 15" = "WEEK 2 DAY 15 value minus baseline",</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a><span class="st">                           "WEEK 3 DAY 22" = "WEEK 3 DAY 22 value minus baseline",</span></span>
+<span id="cb6-51"><a href="#cb6-51"></a><span class="st">                           "WEEK 4 DAY 29" = "WEEK 4 DAY 29 value minus baseline",</span></span>
+<span id="cb6-52"><a href="#cb6-52"></a><span class="st">                           "WEEK 5 DAY 36" = "WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a><span class="st">                           )</span></span>
+<span id="cb6-54"><a href="#cb6-54"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb6-55"><a href="#cb6-55"></a><span class="st">                  dplyr::group_by(USUBJID, PARAM) %&gt;%</span></span>
+<span id="cb6-56"><a href="#cb6-56"></a><span class="st">                  dplyr::mutate(</span></span>
+<span id="cb6-57"><a href="#cb6-57"></a><span class="st">                    AVAL_CHG = AVAL - (!ABLFLL) * sum(AVAL * ABLFLL)</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a><span class="st">                  dplyr::ungroup()  %&gt;%</span></span>
+<span id="cb6-60"><a href="#cb6-60"></a><span class="st">                  var_relabel(</span></span>
+<span id="cb6-61"><a href="#cb6-61"></a><span class="st">                    AVAL_CHG = "Baseline or Absolute Change from Baseline",</span></span>
+<span id="cb6-62"><a href="#cb6-62"></a><span class="st">                    ABLFLL = "Baseline Flag (TRUE/FALSE)",</span></span>
+<span id="cb6-63"><a href="#cb6-63"></a><span class="st">                    AVISIT_header = "Analysis Visit"</span></span>
+<span id="cb6-64"><a href="#cb6-64"></a><span class="st">                  )'</span>),</span>
+<span id="cb6-65"><a href="#cb6-65"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-66"><a href="#cb6-66"></a>  ),</span>
+<span id="cb6-67"><a href="#cb6-67"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-68"><a href="#cb6-68"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb6-69"><a href="#cb6-69"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results Change from Baseline by Visit"</span>,</span>
+<span id="cb6-70"><a href="#cb6-70"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb6-71"><a href="#cb6-71"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-72"><a href="#cb6-72"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-73"><a href="#cb6-73"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-74"><a href="#cb6-74"></a>      ),</span>
+<span id="cb6-75"><a href="#cb6-75"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-76"><a href="#cb6-76"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT_header"</span>)), <span class="co"># note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`</span></span>
+<span id="cb6-77"><a href="#cb6-77"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT_header"</span>)</span>
+<span id="cb6-78"><a href="#cb6-78"></a>      ),</span>
+<span id="cb6-79"><a href="#cb6-79"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-80"><a href="#cb6-80"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>, <span class="st">"AVAL_CHG"</span>)),</span>
+<span id="cb6-81"><a href="#cb6-81"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL_CHG"</span>)</span>
+<span id="cb6-82"><a href="#cb6-82"></a>      ),</span>
+<span id="cb6-83"><a href="#cb6-83"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb6-84"><a href="#cb6-84"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-85"><a href="#cb6-85"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb6-86"><a href="#cb6-86"></a>        <span class="at">selected =</span> <span class="st">"CRP"</span></span>
+<span id="cb6-87"><a href="#cb6-87"></a>      )</span>
+<span id="cb6-88"><a href="#cb6-88"></a>    )</span>
+<span id="cb6-89"><a href="#cb6-89"></a>  ),</span>
+<span id="cb6-90"><a href="#cb6-90"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb6-91"><a href="#cb6-91"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:30:04.6421 pid:12583 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt03_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt03_cache/html/sessioninfo_a4c77264abe1ce41d90890a4e019c293">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt03_cache/html/snapshot_9c02e5d6450ad097e066e579b7afad34">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> LBT03</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results Change from Baseline by Visit</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a>For illustration purposes, this example focuses on "C-Reactive Protein Measurement" starting from baseline, while excluding visit at week 1 for subjects who were randomized to the placebo group.</span>
+<span id="cb12-14"><a href="#cb12-14"></a></span>
+<span id="cb12-15"><a href="#cb12-15"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-17"><a href="#cb12-17"></a></span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-19"><a href="#cb12-19"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-20"><a href="#cb12-20"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-21"><a href="#cb12-21"></a></span>
+<span id="cb12-22"><a href="#cb12-22"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-23"><a href="#cb12-23"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb12-24"><a href="#cb12-24"></a></span>
+<span id="cb12-25"><a href="#cb12-25"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-26"><a href="#cb12-26"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-27"><a href="#cb12-27"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb12-28"><a href="#cb12-28"></a></span>
+<span id="cb12-29"><a href="#cb12-29"></a>saved_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb12-30"><a href="#cb12-30"></a></span>
+<span id="cb12-31"><a href="#cb12-31"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb12-32"><a href="#cb12-32"></a>  <span class="fu">filter</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    PARAM <span class="sc">==</span> <span class="st">"C-Reactive Protein Measurement"</span>,</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    <span class="sc">!</span>(ARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>      AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT),</span>
+<span id="cb12-40"><a href="#cb12-40"></a>    <span class="at">ABLFLL =</span> ABLFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>  )</span>
+<span id="cb12-42"><a href="#cb12-42"></a></span>
+<span id="cb12-43"><a href="#cb12-43"></a><span class="fu">var_labels</span>(adlb_f) <span class="ot">&lt;-</span> <span class="fu">c</span>(saved_labels, <span class="st">""</span>)</span>
+<span id="cb12-44"><a href="#cb12-44"></a><span class="in">```</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a></span>
+<span id="cb12-46"><a href="#cb12-46"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a></span>
+<span id="cb12-48"><a href="#cb12-48"></a>The <span class="in">`LBT03`</span> template is the result of a junction between the analysis of <span class="in">`AVAL`</span> at baseline and <span class="in">`CHG`</span> at visit time.</span>
+<span id="cb12-49"><a href="#cb12-49"></a><span class="in">`AVAL`</span> is summarized for baseline visits and and <span class="in">`CHG`</span> is summarized for post-baseline visits.</span>
+<span id="cb12-50"><a href="#cb12-50"></a></span>
+<span id="cb12-51"><a href="#cb12-51"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-52"><a href="#cb12-52"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-54"><a href="#cb12-54"></a></span>
+<span id="cb12-55"><a href="#cb12-55"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-58"><a href="#cb12-58"></a>  <span class="fu">summarize_change</span>(</span>
+<span id="cb12-59"><a href="#cb12-59"></a>    <span class="st">"CHG"</span>,</span>
+<span id="cb12-60"><a href="#cb12-60"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">value =</span> <span class="st">"AVAL"</span>, <span class="at">baseline_flag =</span> <span class="st">"ABLFLL"</span>),</span>
+<span id="cb12-61"><a href="#cb12-61"></a>    <span class="at">na.rm =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a>  )</span>
+<span id="cb12-63"><a href="#cb12-63"></a></span>
+<span id="cb12-64"><a href="#cb12-64"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-66"><a href="#cb12-66"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb12-67"><a href="#cb12-67"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-68"><a href="#cb12-68"></a>)</span>
+<span id="cb12-69"><a href="#cb12-69"></a></span>
+<span id="cb12-70"><a href="#cb12-70"></a>result</span>
+<span id="cb12-71"><a href="#cb12-71"></a><span class="in">```</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a></span>
+<span id="cb12-73"><a href="#cb12-73"></a>In the final step, a new variable is derived from <span class="in">`AVISIT`</span> that can specify the method of estimation of the evaluated change.</span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-76"><a href="#cb12-76"></a>adlb_f <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(<span class="at">AVISIT_header =</span> <span class="fu">recode</span>(AVISIT,</span>
+<span id="cb12-77"><a href="#cb12-77"></a>  <span class="st">"BASELINE"</span> <span class="ot">=</span> <span class="st">"BASELINE"</span>,</span>
+<span id="cb12-78"><a href="#cb12-78"></a>  <span class="st">"WEEK 1 DAY 8"</span> <span class="ot">=</span> <span class="st">"WEEK 1 DAY 8 value minus baseline"</span>,</span>
+<span id="cb12-79"><a href="#cb12-79"></a>  <span class="st">"WEEK 2 DAY 15"</span> <span class="ot">=</span> <span class="st">"WEEK 2 DAY 15 value minus baseline"</span>,</span>
+<span id="cb12-80"><a href="#cb12-80"></a>  <span class="st">"WEEK 3 DAY 22"</span> <span class="ot">=</span> <span class="st">"WEEK 3 DAY 22 value minus baseline"</span>,</span>
+<span id="cb12-81"><a href="#cb12-81"></a>  <span class="st">"WEEK 4 DAY 29"</span> <span class="ot">=</span> <span class="st">"WEEK 4 DAY 29 value minus baseline"</span>,</span>
+<span id="cb12-82"><a href="#cb12-82"></a>  <span class="st">"WEEK 5 DAY 36"</span> <span class="ot">=</span> <span class="st">"WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>))</span>
+<span id="cb12-84"><a href="#cb12-84"></a></span>
+<span id="cb12-85"><a href="#cb12-85"></a><span class="co"># Define the split function</span></span>
+<span id="cb12-86"><a href="#cb12-86"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-87"><a href="#cb12-87"></a></span>
+<span id="cb12-88"><a href="#cb12-88"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-90"><a href="#cb12-90"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT_header"</span>,</span>
+<span id="cb12-91"><a href="#cb12-91"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb12-92"><a href="#cb12-92"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb12-93"><a href="#cb12-93"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)</span>
+<span id="cb12-94"><a href="#cb12-94"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-95"><a href="#cb12-95"></a>  <span class="fu">summarize_change</span>(</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="st">"CHG"</span>,</span>
+<span id="cb12-97"><a href="#cb12-97"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">value =</span> <span class="st">"AVAL"</span>, <span class="at">baseline_flag =</span> <span class="st">"ABLFLL"</span>),</span>
+<span id="cb12-98"><a href="#cb12-98"></a>    <span class="at">na.rm =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-99"><a href="#cb12-99"></a>  )</span>
+<span id="cb12-100"><a href="#cb12-100"></a></span>
+<span id="cb12-101"><a href="#cb12-101"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb12-102"><a href="#cb12-102"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb12-103"><a href="#cb12-103"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb12-104"><a href="#cb12-104"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb12-105"><a href="#cb12-105"></a>)</span>
+<span id="cb12-106"><a href="#cb12-106"></a></span>
+<span id="cb12-107"><a href="#cb12-107"></a>result</span>
+<span id="cb12-108"><a href="#cb12-108"></a><span class="in">```</span></span>
+<span id="cb12-109"><a href="#cb12-109"></a></span>
+<span id="cb12-110"><a href="#cb12-110"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-111"><a href="#cb12-111"></a></span>
+<span id="cb12-112"><a href="#cb12-112"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a></span>
+<span id="cb12-114"><a href="#cb12-114"></a>Here, we pre-process and manually define the variable "Baseline or Absolute Change from Baseline".</span>
+<span id="cb12-115"><a href="#cb12-115"></a></span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a></span>
+<span id="cb12-119"><a href="#cb12-119"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-120"><a href="#cb12-120"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-121"><a href="#cb12-121"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-122"><a href="#cb12-122"></a></span>
+<span id="cb12-123"><a href="#cb12-123"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(<span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>))</span>
+<span id="cb12-124"><a href="#cb12-124"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(<span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-125"><a href="#cb12-125"></a>  <span class="fu">filter</span>(</span>
+<span id="cb12-126"><a href="#cb12-126"></a>    <span class="sc">!</span>(ARM <span class="sc">==</span> <span class="st">"B: Placebo"</span> <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"WEEK 1 DAY 8"</span>),</span>
+<span id="cb12-127"><a href="#cb12-127"></a>    AVISIT <span class="sc">!=</span> <span class="st">"SCREENING"</span></span>
+<span id="cb12-128"><a href="#cb12-128"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-129"><a href="#cb12-129"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb12-130"><a href="#cb12-130"></a>    <span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT),</span>
+<span id="cb12-131"><a href="#cb12-131"></a>    <span class="at">ABLFLL =</span> ABLFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb12-132"><a href="#cb12-132"></a>    <span class="at">AVISIT_header =</span> <span class="fu">recode</span>(AVISIT,</span>
+<span id="cb12-133"><a href="#cb12-133"></a>      <span class="st">"BASELINE"</span> <span class="ot">=</span> <span class="st">"BASELINE"</span>,</span>
+<span id="cb12-134"><a href="#cb12-134"></a>      <span class="st">"WEEK 1 DAY 8"</span> <span class="ot">=</span> <span class="st">"WEEK 1 DAY 8 value minus baseline"</span>,</span>
+<span id="cb12-135"><a href="#cb12-135"></a>      <span class="st">"WEEK 2 DAY 15"</span> <span class="ot">=</span> <span class="st">"WEEK 2 DAY 15 value minus baseline"</span>,</span>
+<span id="cb12-136"><a href="#cb12-136"></a>      <span class="st">"WEEK 3 DAY 22"</span> <span class="ot">=</span> <span class="st">"WEEK 3 DAY 22 value minus baseline"</span>,</span>
+<span id="cb12-137"><a href="#cb12-137"></a>      <span class="st">"WEEK 4 DAY 29"</span> <span class="ot">=</span> <span class="st">"WEEK 4 DAY 29 value minus baseline"</span>,</span>
+<span id="cb12-138"><a href="#cb12-138"></a>      <span class="st">"WEEK 5 DAY 36"</span> <span class="ot">=</span> <span class="st">"WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb12-139"><a href="#cb12-139"></a>    )</span>
+<span id="cb12-140"><a href="#cb12-140"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-141"><a href="#cb12-141"></a>  dplyr<span class="sc">::</span><span class="fu">group_by</span>(USUBJID, PARAM) <span class="sc">%&gt;%</span></span>
+<span id="cb12-142"><a href="#cb12-142"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb12-143"><a href="#cb12-143"></a>    <span class="at">AVAL_CHG =</span> AVAL <span class="sc">-</span> (<span class="sc">!</span>ABLFLL) <span class="sc">*</span> <span class="fu">sum</span>(AVAL <span class="sc">*</span> ABLFLL)</span>
+<span id="cb12-144"><a href="#cb12-144"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-145"><a href="#cb12-145"></a>  dplyr<span class="sc">::</span><span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb12-146"><a href="#cb12-146"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb12-147"><a href="#cb12-147"></a>    <span class="at">AVAL_CHG =</span> <span class="st">"Baseline or Absolute Change from Baseline"</span>,</span>
+<span id="cb12-148"><a href="#cb12-148"></a>    <span class="at">ABLFLL =</span> <span class="st">"Baseline Flag (TRUE/FALSE)"</span>,</span>
+<span id="cb12-149"><a href="#cb12-149"></a>    <span class="at">AVISIT_header =</span> <span class="st">"Analysis Visit"</span></span>
+<span id="cb12-150"><a href="#cb12-150"></a>  )</span>
+<span id="cb12-151"><a href="#cb12-151"></a></span>
+<span id="cb12-152"><a href="#cb12-152"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-153"><a href="#cb12-153"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-154"><a href="#cb12-154"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))'</span>),</span>
+<span id="cb12-155"><a href="#cb12-155"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb12-156"><a href="#cb12-156"></a><span class="st">                  ADLB &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adlb")) %&gt;%</span></span>
+<span id="cb12-157"><a href="#cb12-157"></a><span class="st">                  filter(</span></span>
+<span id="cb12-158"><a href="#cb12-158"></a><span class="st">                    !(ARM == "B: Placebo" &amp; AVISIT == "WEEK 1 DAY 8"),</span></span>
+<span id="cb12-159"><a href="#cb12-159"></a><span class="st">                    AVISIT != "SCREENING"</span></span>
+<span id="cb12-160"><a href="#cb12-160"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a><span class="st">                  dplyr::mutate(</span></span>
+<span id="cb12-162"><a href="#cb12-162"></a><span class="st">                    AVISIT = droplevels(AVISIT),</span></span>
+<span id="cb12-163"><a href="#cb12-163"></a><span class="st">                    ABLFLL = ABLFL == "Y",</span></span>
+<span id="cb12-164"><a href="#cb12-164"></a><span class="st">                    AVISIT_header = recode(AVISIT,</span></span>
+<span id="cb12-165"><a href="#cb12-165"></a><span class="st">                           "BASELINE" = "BASELINE",</span></span>
+<span id="cb12-166"><a href="#cb12-166"></a><span class="st">                           "WEEK 1 DAY 8" = "WEEK 1 DAY 8 value minus baseline",</span></span>
+<span id="cb12-167"><a href="#cb12-167"></a><span class="st">                           "WEEK 2 DAY 15" = "WEEK 2 DAY 15 value minus baseline",</span></span>
+<span id="cb12-168"><a href="#cb12-168"></a><span class="st">                           "WEEK 3 DAY 22" = "WEEK 3 DAY 22 value minus baseline",</span></span>
+<span id="cb12-169"><a href="#cb12-169"></a><span class="st">                           "WEEK 4 DAY 29" = "WEEK 4 DAY 29 value minus baseline",</span></span>
+<span id="cb12-170"><a href="#cb12-170"></a><span class="st">                           "WEEK 5 DAY 36" = "WEEK 5 DAY 36 value minus baseline"</span></span>
+<span id="cb12-171"><a href="#cb12-171"></a><span class="st">                           )</span></span>
+<span id="cb12-172"><a href="#cb12-172"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb12-173"><a href="#cb12-173"></a><span class="st">                  dplyr::group_by(USUBJID, PARAM) %&gt;%</span></span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="st">                  dplyr::mutate(</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a><span class="st">                    AVAL_CHG = AVAL - (!ABLFLL) * sum(AVAL * ABLFLL)</span></span>
+<span id="cb12-176"><a href="#cb12-176"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a><span class="st">                  dplyr::ungroup()  %&gt;%</span></span>
+<span id="cb12-178"><a href="#cb12-178"></a><span class="st">                  var_relabel(</span></span>
+<span id="cb12-179"><a href="#cb12-179"></a><span class="st">                    AVAL_CHG = "Baseline or Absolute Change from Baseline",</span></span>
+<span id="cb12-180"><a href="#cb12-180"></a><span class="st">                    ABLFLL = "Baseline Flag (TRUE/FALSE)",</span></span>
+<span id="cb12-181"><a href="#cb12-181"></a><span class="st">                    AVISIT_header = "Analysis Visit"</span></span>
+<span id="cb12-182"><a href="#cb12-182"></a><span class="st">                  )'</span>),</span>
+<span id="cb12-183"><a href="#cb12-183"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-184"><a href="#cb12-184"></a>  ),</span>
+<span id="cb12-185"><a href="#cb12-185"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-186"><a href="#cb12-186"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb12-187"><a href="#cb12-187"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results Change from Baseline by Visit"</span>,</span>
+<span id="cb12-188"><a href="#cb12-188"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb12-189"><a href="#cb12-189"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-190"><a href="#cb12-190"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-191"><a href="#cb12-191"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-192"><a href="#cb12-192"></a>      ),</span>
+<span id="cb12-193"><a href="#cb12-193"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-194"><a href="#cb12-194"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT_header"</span>)), <span class="co"># note: order matters here. If `PARAM` is first, the split will be first by `PARAM`and then by `AVISIT`</span></span>
+<span id="cb12-195"><a href="#cb12-195"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT_header"</span>)</span>
+<span id="cb12-196"><a href="#cb12-196"></a>      ),</span>
+<span id="cb12-197"><a href="#cb12-197"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-198"><a href="#cb12-198"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>, <span class="st">"AVAL_CHG"</span>)),</span>
+<span id="cb12-199"><a href="#cb12-199"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL_CHG"</span>)</span>
+<span id="cb12-200"><a href="#cb12-200"></a>      ),</span>
+<span id="cb12-201"><a href="#cb12-201"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb12-202"><a href="#cb12-202"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-203"><a href="#cb12-203"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-204"><a href="#cb12-204"></a>        <span class="at">selected =</span> <span class="st">"CRP"</span></span>
+<span id="cb12-205"><a href="#cb12-205"></a>      )</span>
+<span id="cb12-206"><a href="#cb12-206"></a>    )</span>
+<span id="cb12-207"><a href="#cb12-207"></a>  ),</span>
+<span id="cb12-208"><a href="#cb12-208"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb12-209"><a href="#cb12-209"></a>)</span>
+<span id="cb12-210"><a href="#cb12-210"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-211"><a href="#cb12-211"></a><span class="in">```</span></span>
+<span id="cb12-212"><a href="#cb12-212"></a></span>
+<span id="cb12-213"><a href="#cb12-213"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-214"><a href="#cb12-214"></a></span>
+<span id="cb12-215"><a href="#cb12-215"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
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+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Abnormalities Not Present at Baseline</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt04_cache/html/setup_ea61752d64ece8929d0d57bd1a15f361">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>, ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">PARAM =</span> <span class="st">"Laboratory Test"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt04_cache/html/variant1_ba91e95834c1ac496f7c2b79ff172e58">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">var =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">append_varlabels</span>(adlb_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Laboratory Test                          A: Drug X        B: Placebo     C: Combination
+  Direction of Abnormality                (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                   
+  Low                                  57/113 (50.4%)    62/117 (53%)    61/123 (49.6%)
+  High                                     0/134            0/134            0/132     
+C-Reactive Protein Measurement                                                         
+  Low                                  78/119 (65.5%)   71/113 (62.8%)   62/112 (55.4%)
+  High                                 69/114 (60.5%)   57/112 (50.9%)   58/115 (50.4%)
+Immunoglobulin A Measurement                                                           
+  Low                                      0/134            0/134            0/132     
+  High                                 64/119 (53.8%)   62/116 (53.4%)   62/113 (54.9%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="lbt04_cache/html/teal_3cffa5e0056cddefcc24002f23e1bfd0">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">var_relabel</span>(<span class="at">PARAM =</span> <span class="st">"Laboratory Test"</span>, <span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a><span class="st">                  ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a><span class="st">                var_relabel(PARAM = "Laboratory Test", ANRIND = "Direction of Abnormality")'</span>),</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>  ),</span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-18"><a href="#cb4-18"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>      ),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"LBCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-27"><a href="#cb4-27"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"LBCAT"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-28"><a href="#cb4-28"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>      ),</span>
+<span id="cb4-30"><a href="#cb4-30"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb4-32"><a href="#cb4-32"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>      ),</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">low =</span> <span class="st">"LOW"</span>, <span class="at">high =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>    )</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  )</span>
+<span id="cb4-39"><a href="#cb4-39"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:29:24.3421 pid:12485 token:[] teal.modules.clinical Initializing tm_t_abnormality</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt04_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt04_cache/html/sessioninfo_be1217b11ff4c2a49938a9e55de37b26">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt04_cache/html/snapshot_f87c4635ac865761551bad8217fa60c5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt05.html" class="pagination-link">
+        <span class="nav-page-text">LBT05</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT04</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Abnormalities Not Present at Baseline</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>, ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    <span class="at">PARAM =</span> <span class="st">"Laboratory Test"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    <span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  )</span>
+<span id="cb10-33"><a href="#cb10-33"></a><span class="in">```</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a></span>
+<span id="cb10-35"><a href="#cb10-35"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a></span>
+<span id="cb10-37"><a href="#cb10-37"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>,</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)</span>
+<span id="cb10-44"><a href="#cb10-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">var =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="fu">append_varlabels</span>(adlb_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb10-51"><a href="#cb10-51"></a></span>
+<span id="cb10-52"><a href="#cb10-52"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-53"><a href="#cb10-53"></a></span>
+<span id="cb10-54"><a href="#cb10-54"></a>result</span>
+<span id="cb10-55"><a href="#cb10-55"></a><span class="in">```</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a></span>
+<span id="cb10-57"><a href="#cb10-57"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-58"><a href="#cb10-58"></a></span>
+<span id="cb10-59"><a href="#cb10-59"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a></span>
+<span id="cb10-61"><a href="#cb10-61"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb10-63"><a href="#cb10-63"></a></span>
+<span id="cb10-64"><a href="#cb10-64"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-69"><a href="#cb10-69"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a>  <span class="fu">var_relabel</span>(<span class="at">PARAM =</span> <span class="st">"Laboratory Test"</span>, <span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-74"><a href="#cb10-74"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-75"><a href="#cb10-75"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a><span class="st">                  ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="st">                var_relabel(PARAM = "Laboratory Test", ANRIND = "Direction of Abnormality")'</span>),</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-79"><a href="#cb10-79"></a>  ),</span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-81"><a href="#cb10-81"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb10-82"><a href="#cb10-82"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb10-83"><a href="#cb10-83"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb10-84"><a href="#cb10-84"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-85"><a href="#cb10-85"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-86"><a href="#cb10-86"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a>      ),</span>
+<span id="cb10-88"><a href="#cb10-88"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-89"><a href="#cb10-89"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"LBCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-90"><a href="#cb10-90"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"LBCAT"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-91"><a href="#cb10-91"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a>      ),</span>
+<span id="cb10-93"><a href="#cb10-93"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-94"><a href="#cb10-94"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb10-95"><a href="#cb10-95"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb10-96"><a href="#cb10-96"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a>      ),</span>
+<span id="cb10-98"><a href="#cb10-98"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">low =</span> <span class="st">"LOW"</span>, <span class="at">high =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb10-99"><a href="#cb10-99"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a>    )</span>
+<span id="cb10-101"><a href="#cb10-101"></a>  )</span>
+<span id="cb10-102"><a href="#cb10-102"></a>)</span>
+<span id="cb10-103"><a href="#cb10-103"></a></span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-105"><a href="#cb10-105"></a><span class="in">```</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a></span>
+<span id="cb10-107"><a href="#cb10-107"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-108"><a href="#cb10-108"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
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+ <span class="menu-text">PKCG01</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
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+ <span class="menu-text">PKPG04</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<div class="quarto-title-block"><div><h1 class="title">LBT05</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Abnormalities with Single and Replicated Marked</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Showing <br> All Categories</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with <br> Study-Specific <br> MLAs</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table of Lab Abnormalities Showing <br> All Categories But Only for Parameter <br> Codes with At Least One Abnormality</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt05_cache/html/setup_d40222a35bc84fc259fe7c342c45915b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>qntls <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">group_by</span>(PARAMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">summarise</span>(<span class="fu">as_tibble</span>(<span class="fu">t</span>(<span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>, <span class="fl">0.9</span>)))), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">rename</span>(<span class="at">q1 =</span> <span class="dv">2</span>, <span class="at">q2 =</span> <span class="dv">3</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">left_join</span>(qntls, <span class="at">by =</span> <span class="st">"PARAMCD"</span>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a><span class="fu">set.seed</span>(<span class="dv">1</span>)</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a><span class="co"># Modify ANRIND and create AVALCAT1/PARCAT2</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># PARCAT2 is just used for filtering, but in order to be the</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="co"># filtering as realistic as possible, will create the variable.</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-29"><a href="#cb1-29"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> q1 <span class="sc">~</span> <span class="st">"LOW LOW"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> q2 <span class="sc">~</span> <span class="st">"HIGH HIGH"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      ),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>, <span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    ),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"HIGH HIGH"</span>, <span class="st">"LOW LOW"</span>) <span class="sc">~</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>          <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">c</span>(<span class="st">"LAST"</span>, <span class="st">"REPLICATED"</span>, <span class="st">"SINGLE"</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.3</span>, <span class="fl">0.6</span>, <span class="fl">0.1</span>)),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>      ),</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="fu">c</span>(<span class="st">"LAST"</span>, <span class="st">"REPLICATED"</span>, <span class="st">"SINGLE"</span>))</span>
+<span id="cb1-42"><a href="#cb1-42"></a>    ),</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">PARCAT2 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"HIGH HIGH"</span>, <span class="st">"LOW LOW"</span>), <span class="st">"LS"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>      <span class="fu">sample</span>(<span class="fu">c</span>(<span class="st">"SI"</span>, <span class="st">"CV"</span>, <span class="st">"LS"</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    ))</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">select</span>(<span class="sc">-</span>q1, <span class="sc">-</span>q2)</span>
+<span id="cb1-48"><a href="#cb1-48"></a></span>
+<span id="cb1-49"><a href="#cb1-49"></a><span class="co"># Pre-processing steps</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> PARCAT2 <span class="sc">==</span> <span class="st">"LS"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="fu">mutate</span>(<span class="at">abn_dir =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    ANRIND <span class="sc">==</span> <span class="st">"LOW LOW"</span> <span class="sc">~</span> <span class="st">"Low"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    ANRIND <span class="sc">==</span> <span class="st">"HIGH HIGH"</span> <span class="sc">~</span> <span class="st">"High"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb1-56"><a href="#cb1-56"></a>  ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Low"</span>, <span class="st">"High"</span>, <span class="st">""</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb1-58"><a href="#cb1-58"></a></span>
+<span id="cb1-59"><a href="#cb1-59"></a><span class="co"># Construct analysis map</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a>map <span class="ot">&lt;-</span> <span class="fu">expand.grid</span>(</span>
+<span id="cb1-61"><a href="#cb1-61"></a>  <span class="at">PARAM =</span> <span class="fu">levels</span>(adlb<span class="sc">$</span>PARAM),</span>
+<span id="cb1-62"><a href="#cb1-62"></a>  <span class="at">abn_dir =</span> <span class="fu">c</span>(<span class="st">"Low"</span>, <span class="st">"High"</span>),</span>
+<span id="cb1-63"><a href="#cb1-63"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-65"><a href="#cb1-65"></a>  <span class="fu">arrange</span>(PARAM, <span class="fu">desc</span>(abn_dir))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt05_cache/html/variant1_7dd1af36a88e44c35b7e8be62eda6447">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb2-15"><a href="#cb2-15"></a></span>
+<span id="cb2-16"><a href="#cb2-16"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>has_lbl <span class="ot">&lt;-</span> <span class="cf">function</span>(lbl) <span class="fu">CombinationFunction</span>(<span class="cf">function</span>(tr) <span class="fu">obj_label</span>(tr) <span class="sc">==</span> lbl <span class="sc">||</span> <span class="fu">sum</span>(<span class="fu">unlist</span>(<span class="fu">row_values</span>(tr))) <span class="sc">!=</span> <span class="dv">0</span>)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(<span class="fu">has_lbl</span>(<span class="st">"Any Abnormality"</span>)))</span>
+<span id="cb2-20"><a href="#cb2-20"></a></span>
+<span id="cb2-21"><a href="#cb2-21"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Laboratory Test                            A: Drug X    B: Placebo   C: Combination
+  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (n)      125          120            125      
+  Low                                                                              
+    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    
+    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  
+    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  
+  High                                                                             
+    Any Abnormality                            0            0              0       
+C-Reactive Protein Measurement (n)            129          130            121      
+  Low                                                                              
+    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    
+    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  
+    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  
+  High                                                                             
+    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   
+    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  
+    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  
+Immunoglobulin A Measurement (n)              129          122            121      
+  Low                                                                              
+    Any Abnormality                            0            0              0       
+  High                                                                             
+    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   
+    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  
+    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt05_cache/html/variant2_7ae3df15cd7ff9a9183f22029762cdb3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb4-13"><a href="#cb4-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-17"><a href="#cb4-17"></a></span>
+<span id="cb4-18"><a href="#cb4-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Laboratory Test                            A: Drug X    B: Placebo   C: Combination
+  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (n)      125          120            125      
+  Low                                                                              
+    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    
+    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  
+    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  
+  High                                                                             
+    Single, not last                           0            0              0       
+    Last or replicated                         0            0              0       
+    Any Abnormality                            0            0              0       
+C-Reactive Protein Measurement (n)            129          130            121      
+  Low                                                                              
+    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    
+    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  
+    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  
+  High                                                                             
+    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   
+    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  
+    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  
+Immunoglobulin A Measurement (n)              129          122            121      
+  Low                                                                              
+    Single, not last                           0            0              0       
+    Last or replicated                         0            0              0       
+    Any Abnormality                            0            0              0       
+  High                                                                             
+    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   
+    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  
+    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-hash="lbt05_cache/html/variant3_6a40b0d9e4cbd5d0f46365b6fcdee39d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># This variant reflects user modifications made to the laboratory analysis data set related to Safety Lab Standardization metadata.</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="co"># There is no unique layout level variation.</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="lbt05_cache/html/variant4_61ab623b429a974629015451590d3fae">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-2"><a href="#cb7-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-3"><a href="#cb7-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb7-4"><a href="#cb7-4"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb7-5"><a href="#cb7-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb7-6"><a href="#cb7-6"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span>,</span>
+<span id="cb7-7"><a href="#cb7-7"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"abn_dir"</span>, <span class="at">drop_outlevs =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-8"><a href="#cb7-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-10"><a href="#cb7-10"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb7-11"><a href="#cb7-11"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb7-12"><a href="#cb7-12"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb7-13"><a href="#cb7-13"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb7-14"><a href="#cb7-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb7-15"><a href="#cb7-15"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb7-16"><a href="#cb7-16"></a></span>
+<span id="cb7-17"><a href="#cb7-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb7-18"><a href="#cb7-18"></a></span>
+<span id="cb7-19"><a href="#cb7-19"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb7-20"><a href="#cb7-20"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Laboratory Test                            A: Drug X    B: Placebo   C: Combination
+  Direction of Abnormality                  (N=134)      (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (n)      125          120            125      
+  Low                                                                              
+    Single, not last                        3 (2.4%)     5 (4.2%)        5 (4%)    
+    Last or replicated                     52 (41.6%)   59 (49.2%)     44 (35.2%)  
+    Any Abnormality                         55 (44%)    64 (53.3%)     49 (39.2%)  
+C-Reactive Protein Measurement (n)            129          130            121      
+  Low                                                                              
+    Single, not last                        3 (2.3%)     7 (5.4%)        6 (5%)    
+    Last or replicated                     59 (45.7%)   50 (38.5%)     49 (40.5%)  
+    Any Abnormality                        62 (48.1%)   57 (43.8%)     55 (45.5%)  
+  High                                                                             
+    Single, not last                        5 (3.9%)     4 (3.1%)       2 (1.7%)   
+    Last or replicated                      49 (38%)    54 (41.5%)     45 (37.2%)  
+    Any Abnormality                        54 (41.9%)   58 (44.6%)     47 (38.8%)  
+Immunoglobulin A Measurement (n)              129          122            121      
+  High                                                                             
+    Single, not last                        4 (3.1%)     6 (4.9%)       3 (2.5%)   
+    Last or replicated                     48 (37.2%)   47 (38.5%)     55 (45.5%)  
+    Any Abnormality                        52 (40.3%)   53 (43.4%)     58 (47.9%)  </code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="co"># Another approach would be to create an empirical map by removing the ALT records</span></span>
+<span id="cb9-2"><a href="#cb9-2"></a><span class="co"># and use it in `trim_levels_to_map`.</span></span>
+<span id="cb9-3"><a href="#cb9-3"></a><span class="co"># this is an a posteriori approach, though.</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt05_cache/html/sessioninfo_a5b021a972bc484f2fccf8aa2a2b8be3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         withr_2.5.0       Rdpack_2.5       
+[33] digest_0.6.33     grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3  
+[37] vctrs_0.6.3       evaluate_0.21     glue_1.6.2        codetools_0.2-19 
+[41] survival_3.5-7    fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2      
+[45] rmarkdown_2.25    tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt05_cache/html/snapshot_94756c72d2ba955927273ba4fe8155ed">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-2"><a href="#cb12-2"></a></span>
+<span id="cb12-3"><a href="#cb12-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb12-10"><a href="#cb12-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-11"><a href="#cb12-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt05.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
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+window.document.addEventListener("DOMContentLoaded", function (event) {
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+    let styleSentinel = getColorSchemeSentinel();
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb13" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb13-1"><a href="#cb13-1"></a><span class="co">---</span></span>
+<span id="cb13-2"><a href="#cb13-2"></a><span class="an">title:</span><span class="co"> LBT05</span></span>
+<span id="cb13-3"><a href="#cb13-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Abnormalities with Single and Replicated Marked</span></span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="co">---</span></span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>------------------------------------------------------------------------</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb13-9"><a href="#cb13-9"></a></span>
+<span id="cb13-10"><a href="#cb13-10"></a>::: panel-tabset</span>
+<span id="cb13-11"><a href="#cb13-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb13-12"><a href="#cb13-12"></a></span>
+<span id="cb13-13"><a href="#cb13-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb13-14"><a href="#cb13-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb13-15"><a href="#cb13-15"></a></span>
+<span id="cb13-16"><a href="#cb13-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb13-17"><a href="#cb13-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb13-18"><a href="#cb13-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb13-19"><a href="#cb13-19"></a></span>
+<span id="cb13-20"><a href="#cb13-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb13-21"><a href="#cb13-21"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb13-22"><a href="#cb13-22"></a></span>
+<span id="cb13-23"><a href="#cb13-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb13-24"><a href="#cb13-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb13-25"><a href="#cb13-25"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb13-26"><a href="#cb13-26"></a></span>
+<span id="cb13-27"><a href="#cb13-27"></a>qntls <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb13-28"><a href="#cb13-28"></a>  <span class="fu">group_by</span>(PARAMCD) <span class="sc">%&gt;%</span></span>
+<span id="cb13-29"><a href="#cb13-29"></a>  <span class="fu">summarise</span>(<span class="fu">as_tibble</span>(<span class="fu">t</span>(<span class="fu">quantile</span>(AVAL, <span class="at">probs =</span> <span class="fu">c</span>(<span class="fl">0.1</span>, <span class="fl">0.9</span>)))), <span class="at">.groups =</span> <span class="st">"drop_last"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-30"><a href="#cb13-30"></a>  <span class="fu">rename</span>(<span class="at">q1 =</span> <span class="dv">2</span>, <span class="at">q2 =</span> <span class="dv">3</span>)</span>
+<span id="cb13-31"><a href="#cb13-31"></a></span>
+<span id="cb13-32"><a href="#cb13-32"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb13-33"><a href="#cb13-33"></a>  <span class="fu">left_join</span>(qntls, <span class="at">by =</span> <span class="st">"PARAMCD"</span>)</span>
+<span id="cb13-34"><a href="#cb13-34"></a></span>
+<span id="cb13-35"><a href="#cb13-35"></a><span class="fu">set.seed</span>(<span class="dv">1</span>)</span>
+<span id="cb13-36"><a href="#cb13-36"></a></span>
+<span id="cb13-37"><a href="#cb13-37"></a><span class="co"># Modify ANRIND and create AVALCAT1/PARCAT2</span></span>
+<span id="cb13-38"><a href="#cb13-38"></a><span class="co"># PARCAT2 is just used for filtering, but in order to be the</span></span>
+<span id="cb13-39"><a href="#cb13-39"></a><span class="co"># filtering as realistic as possible, will create the variable.</span></span>
+<span id="cb13-40"><a href="#cb13-40"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb13-41"><a href="#cb13-41"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb13-42"><a href="#cb13-42"></a>    <span class="at">ANRIND =</span> <span class="fu">factor</span>(</span>
+<span id="cb13-43"><a href="#cb13-43"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb13-44"><a href="#cb13-44"></a>        ANRIND <span class="sc">==</span> <span class="st">"LOW"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&lt;=</span> q1 <span class="sc">~</span> <span class="st">"LOW LOW"</span>,</span>
+<span id="cb13-45"><a href="#cb13-45"></a>        ANRIND <span class="sc">==</span> <span class="st">"HIGH"</span> <span class="sc">&amp;</span> AVAL <span class="sc">&gt;=</span> q2 <span class="sc">~</span> <span class="st">"HIGH HIGH"</span>,</span>
+<span id="cb13-46"><a href="#cb13-46"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="fu">as.character</span>(ANRIND)</span>
+<span id="cb13-47"><a href="#cb13-47"></a>      ),</span>
+<span id="cb13-48"><a href="#cb13-48"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>, <span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>, <span class="st">"NORMAL"</span>)</span>
+<span id="cb13-49"><a href="#cb13-49"></a>    ),</span>
+<span id="cb13-50"><a href="#cb13-50"></a>    <span class="at">AVALCAT1 =</span> <span class="fu">factor</span>(</span>
+<span id="cb13-51"><a href="#cb13-51"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb13-52"><a href="#cb13-52"></a>        ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"HIGH HIGH"</span>, <span class="st">"LOW LOW"</span>) <span class="sc">~</span></span>
+<span id="cb13-53"><a href="#cb13-53"></a>          <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">c</span>(<span class="st">"LAST"</span>, <span class="st">"REPLICATED"</span>, <span class="st">"SINGLE"</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>, <span class="at">prob =</span> <span class="fu">c</span>(<span class="fl">0.3</span>, <span class="fl">0.6</span>, <span class="fl">0.1</span>)),</span>
+<span id="cb13-54"><a href="#cb13-54"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb13-55"><a href="#cb13-55"></a>      ),</span>
+<span id="cb13-56"><a href="#cb13-56"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">""</span>, <span class="fu">c</span>(<span class="st">"LAST"</span>, <span class="st">"REPLICATED"</span>, <span class="st">"SINGLE"</span>))</span>
+<span id="cb13-57"><a href="#cb13-57"></a>    ),</span>
+<span id="cb13-58"><a href="#cb13-58"></a>    <span class="at">PARCAT2 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(ANRIND <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"HIGH HIGH"</span>, <span class="st">"LOW LOW"</span>), <span class="st">"LS"</span>,</span>
+<span id="cb13-59"><a href="#cb13-59"></a>      <span class="fu">sample</span>(<span class="fu">c</span>(<span class="st">"SI"</span>, <span class="st">"CV"</span>, <span class="st">"LS"</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-60"><a href="#cb13-60"></a>    ))</span>
+<span id="cb13-61"><a href="#cb13-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-62"><a href="#cb13-62"></a>  <span class="fu">select</span>(<span class="sc">-</span>q1, <span class="sc">-</span>q2)</span>
+<span id="cb13-63"><a href="#cb13-63"></a></span>
+<span id="cb13-64"><a href="#cb13-64"></a><span class="co"># Pre-processing steps</span></span>
+<span id="cb13-65"><a href="#cb13-65"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb13-66"><a href="#cb13-66"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> PARCAT2 <span class="sc">==</span> <span class="st">"LS"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> <span class="sc">!</span><span class="fu">is.na</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-67"><a href="#cb13-67"></a>  <span class="fu">mutate</span>(<span class="at">abn_dir =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb13-68"><a href="#cb13-68"></a>    ANRIND <span class="sc">==</span> <span class="st">"LOW LOW"</span> <span class="sc">~</span> <span class="st">"Low"</span>,</span>
+<span id="cb13-69"><a href="#cb13-69"></a>    ANRIND <span class="sc">==</span> <span class="st">"HIGH HIGH"</span> <span class="sc">~</span> <span class="st">"High"</span>,</span>
+<span id="cb13-70"><a href="#cb13-70"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">""</span></span>
+<span id="cb13-71"><a href="#cb13-71"></a>  ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Low"</span>, <span class="st">"High"</span>, <span class="st">""</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb13-72"><a href="#cb13-72"></a>  <span class="fu">df_explicit_na</span>()</span>
+<span id="cb13-73"><a href="#cb13-73"></a></span>
+<span id="cb13-74"><a href="#cb13-74"></a><span class="co"># Construct analysis map</span></span>
+<span id="cb13-75"><a href="#cb13-75"></a>map <span class="ot">&lt;-</span> <span class="fu">expand.grid</span>(</span>
+<span id="cb13-76"><a href="#cb13-76"></a>  <span class="at">PARAM =</span> <span class="fu">levels</span>(adlb<span class="sc">$</span>PARAM),</span>
+<span id="cb13-77"><a href="#cb13-77"></a>  <span class="at">abn_dir =</span> <span class="fu">c</span>(<span class="st">"Low"</span>, <span class="st">"High"</span>),</span>
+<span id="cb13-78"><a href="#cb13-78"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb13-79"><a href="#cb13-79"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-80"><a href="#cb13-80"></a>  <span class="fu">arrange</span>(PARAM, <span class="fu">desc</span>(abn_dir))</span>
+<span id="cb13-81"><a href="#cb13-81"></a><span class="in">```</span></span>
+<span id="cb13-82"><a href="#cb13-82"></a></span>
+<span id="cb13-83"><a href="#cb13-83"></a><span class="fu">## Standard Table</span></span>
+<span id="cb13-84"><a href="#cb13-84"></a></span>
+<span id="cb13-85"><a href="#cb13-85"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb13-86"><a href="#cb13-86"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-87"><a href="#cb13-87"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-88"><a href="#cb13-88"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb13-89"><a href="#cb13-89"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb13-90"><a href="#cb13-90"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb13-91"><a href="#cb13-91"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span></span>
+<span id="cb13-92"><a href="#cb13-92"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-93"><a href="#cb13-93"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-94"><a href="#cb13-94"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-95"><a href="#cb13-95"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb13-96"><a href="#cb13-96"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb13-97"><a href="#cb13-97"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb13-98"><a href="#cb13-98"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-99"><a href="#cb13-99"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb13-100"><a href="#cb13-100"></a></span>
+<span id="cb13-101"><a href="#cb13-101"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb13-102"><a href="#cb13-102"></a></span>
+<span id="cb13-103"><a href="#cb13-103"></a>has_lbl <span class="ot">&lt;-</span> <span class="cf">function</span>(lbl) <span class="fu">CombinationFunction</span>(<span class="cf">function</span>(tr) <span class="fu">obj_label</span>(tr) <span class="sc">==</span> lbl <span class="sc">||</span> <span class="fu">sum</span>(<span class="fu">unlist</span>(<span class="fu">row_values</span>(tr))) <span class="sc">!=</span> <span class="dv">0</span>)</span>
+<span id="cb13-104"><a href="#cb13-104"></a>result <span class="ot">&lt;-</span> <span class="fu">prune_table</span>(result, <span class="fu">keep_rows</span>(<span class="fu">has_lbl</span>(<span class="st">"Any Abnormality"</span>)))</span>
+<span id="cb13-105"><a href="#cb13-105"></a></span>
+<span id="cb13-106"><a href="#cb13-106"></a>result</span>
+<span id="cb13-107"><a href="#cb13-107"></a><span class="in">```</span></span>
+<span id="cb13-108"><a href="#cb13-108"></a></span>
+<span id="cb13-109"><a href="#cb13-109"></a><span class="fu">## Table Showing &lt;br/&gt; All Categories</span></span>
+<span id="cb13-110"><a href="#cb13-110"></a></span>
+<span id="cb13-111"><a href="#cb13-111"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb13-112"><a href="#cb13-112"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-113"><a href="#cb13-113"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-114"><a href="#cb13-114"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb13-115"><a href="#cb13-115"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb13-116"><a href="#cb13-116"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb13-117"><a href="#cb13-117"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span></span>
+<span id="cb13-118"><a href="#cb13-118"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-119"><a href="#cb13-119"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-120"><a href="#cb13-120"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)) <span class="sc">%&gt;%</span></span>
+<span id="cb13-121"><a href="#cb13-121"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb13-122"><a href="#cb13-122"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb13-123"><a href="#cb13-123"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb13-124"><a href="#cb13-124"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-125"><a href="#cb13-125"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb13-126"><a href="#cb13-126"></a></span>
+<span id="cb13-127"><a href="#cb13-127"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb13-128"><a href="#cb13-128"></a></span>
+<span id="cb13-129"><a href="#cb13-129"></a>result</span>
+<span id="cb13-130"><a href="#cb13-130"></a><span class="in">```</span></span>
+<span id="cb13-131"><a href="#cb13-131"></a></span>
+<span id="cb13-132"><a href="#cb13-132"></a><span class="fu">## Table with &lt;br/&gt; Study-Specific &lt;br/&gt; MLAs</span></span>
+<span id="cb13-133"><a href="#cb13-133"></a></span>
+<span id="cb13-134"><a href="#cb13-134"></a><span class="in">```{r variant3}</span></span>
+<span id="cb13-135"><a href="#cb13-135"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb13-136"><a href="#cb13-136"></a></span>
+<span id="cb13-137"><a href="#cb13-137"></a><span class="co"># This variant reflects user modifications made to the laboratory analysis data set related to Safety Lab Standardization metadata.</span></span>
+<span id="cb13-138"><a href="#cb13-138"></a><span class="co"># There is no unique layout level variation.</span></span>
+<span id="cb13-139"><a href="#cb13-139"></a><span class="in">```</span></span>
+<span id="cb13-140"><a href="#cb13-140"></a></span>
+<span id="cb13-141"><a href="#cb13-141"></a><span class="fu">## Table of Lab Abnormalities Showing &lt;br/&gt; All Categories But Only for Parameter &lt;br/&gt; Codes with At Least One Abnormality</span></span>
+<span id="cb13-142"><a href="#cb13-142"></a></span>
+<span id="cb13-143"><a href="#cb13-143"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb13-144"><a href="#cb13-144"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-145"><a href="#cb13-145"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-146"><a href="#cb13-146"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb13-147"><a href="#cb13-147"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb13-148"><a href="#cb13-148"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb13-149"><a href="#cb13-149"></a>    <span class="at">split_label =</span> <span class="st">"Laboratory Test"</span>,</span>
+<span id="cb13-150"><a href="#cb13-150"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"abn_dir"</span>, <span class="at">drop_outlevs =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-151"><a href="#cb13-151"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-152"><a href="#cb13-152"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="st">"unique_count"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-153"><a href="#cb13-153"></a>  <span class="fu">split_rows_by</span>(<span class="st">"abn_dir"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb13-154"><a href="#cb13-154"></a>  <span class="fu">count_abnormal_by_marked</span>(</span>
+<span id="cb13-155"><a href="#cb13-155"></a>    <span class="at">var =</span> <span class="st">"AVALCAT1"</span>,</span>
+<span id="cb13-156"><a href="#cb13-156"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">direction =</span> <span class="st">"abn_dir"</span>)</span>
+<span id="cb13-157"><a href="#cb13-157"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb13-158"><a href="#cb13-158"></a>  <span class="fu">append_topleft</span>(<span class="st">"  Direction of Abnormality"</span>)</span>
+<span id="cb13-159"><a href="#cb13-159"></a></span>
+<span id="cb13-160"><a href="#cb13-160"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb13-161"><a href="#cb13-161"></a></span>
+<span id="cb13-162"><a href="#cb13-162"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb13-163"><a href="#cb13-163"></a>result</span>
+<span id="cb13-164"><a href="#cb13-164"></a></span>
+<span id="cb13-165"><a href="#cb13-165"></a><span class="co"># Another approach would be to create an empirical map by removing the ALT records</span></span>
+<span id="cb13-166"><a href="#cb13-166"></a><span class="co"># and use it in `trim_levels_to_map`.</span></span>
+<span id="cb13-167"><a href="#cb13-167"></a><span class="co"># this is an a posteriori approach, though.</span></span>
+<span id="cb13-168"><a href="#cb13-168"></a><span class="in">```</span></span>
+<span id="cb13-169"><a href="#cb13-169"></a></span>
+<span id="cb13-170"><a href="#cb13-170"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb13-171"><a href="#cb13-171"></a></span>
+<span id="cb13-172"><a href="#cb13-172"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb13-173"><a href="#cb13-173"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+          <li class="sidebar-item">
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+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">ECG</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
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+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT06</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Abnormalities by Visit and Baseline Status</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table for <br> Single Lab Test</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Standard Table for <br> Multiple Lab Tests</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt06_cache/html/setup_d013104c4f75f786c80327add43f3926">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Please note that df_explict_na has a na_level argument defaulting to "&lt;Missing&gt;",</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Please don't change the na_level to anything other than NA, empty string or the default "&lt;Missing&gt;".</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="sc">!</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">var_relabel</span>(<span class="at">AVISIT =</span> <span class="st">"Visit"</span>)</span>
+<span id="cb1-19"><a href="#cb1-19"></a></span>
+<span id="cb1-20"><a href="#cb1-20"></a>adlb_f_crp <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt06_cache/html/variant1_3c4e99a80164ea9553e9d253d6957ba5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f_crp<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_abnormal_by_baseline</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">abnormal =</span> <span class="fu">c</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">append_varlabels</span>(adlb_f_crp, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Baseline Status"</span>)</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="at">df =</span> adlb_f_crp,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb2-19"><a href="#cb2-19"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-20"><a href="#cb2-20"></a>  <span class="fu">trim_rows</span>()</span>
+<span id="cb2-21"><a href="#cb2-21"></a></span>
+<span id="cb2-22"><a href="#cb2-22"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Visit                                                                                  
+  Analysis Reference Range Indicator     A: Drug X        B: Placebo     C: Combination
+    Baseline Status                       (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————
+WEEK 1 DAY 8                                                                           
+  Low                                                                                  
+            Not low                    16/119 (13.4%)   22/113 (19.5%)   24/112 (21.4%)
+            Low                         2/15 (13.3%)     2/21 (9.5%)       7/20 (35%)  
+            Total                      18/134 (13.4%)   24/134 (17.9%)   31/132 (23.5%)
+  High                                                                                 
+            Not high                   21/114 (18.4%)   20/112 (17.9%)   17/115 (14.8%)
+            High                         2/20 (10%)      4/22 (18.2%)     3/17 (17.6%) 
+            Total                      23/134 (17.2%)   24/134 (17.9%)   20/132 (15.2%)
+WEEK 2 DAY 15                                                                          
+  Low                                                                                  
+            Not low                    26/119 (21.8%)   20/113 (17.7%)   12/112 (10.7%)
+            Low                         2/15 (13.3%)     3/21 (14.3%)      4/20 (20%)  
+            Total                      28/134 (20.9%)   23/134 (17.2%)   16/132 (12.1%)
+  High                                                                                 
+            Not high                   15/114 (13.2%)   17/112 (15.2%)    15/115 (13%) 
+            High                         2/20 (10%)      4/22 (18.2%)     4/17 (23.5%) 
+            Total                      17/134 (12.7%)   21/134 (15.7%)   19/132 (14.4%)
+WEEK 3 DAY 22                                                                          
+  Low                                                                                  
+            Not low                    15/119 (12.6%)   21/113 (18.6%)   18/112 (16.1%)
+            Low                             0/15         3/21 (14.3%)         0/20     
+            Total                      15/134 (11.2%)   24/134 (17.9%)   18/132 (13.6%)
+  High                                                                                 
+            Not high                   22/114 (19.3%)   18/112 (16.1%)   17/115 (14.8%)
+            High                         2/20 (10%)      5/22 (22.7%)     1/17 (5.9%)  
+            Total                      24/134 (17.9%)   23/134 (17.2%)   18/132 (13.6%)
+WEEK 4 DAY 29                                                                          
+  Low                                                                                  
+            Not low                    30/119 (25.2%)   13/113 (11.5%)   16/112 (14.3%)
+            Low                          3/15 (20%)      2/21 (9.5%)       5/20 (25%)  
+            Total                      33/134 (24.6%)   15/134 (11.2%)   21/132 (15.9%)
+  High                                                                                 
+            Not high                   17/114 (14.9%)   11/112 (9.8%)    16/115 (13.9%)
+            High                         2/20 (10%)      6/22 (27.3%)     3/17 (17.6%) 
+            Total                      19/134 (14.2%)   17/134 (12.7%)   19/132 (14.4%)
+WEEK 5 DAY 36                                                                          
+  Low                                                                                  
+            Not low                    17/119 (14.3%)   19/113 (16.8%)   16/112 (14.3%)
+            Low                         2/15 (13.3%)     3/21 (14.3%)      5/20 (25%)  
+            Total                      19/134 (14.2%)   22/134 (16.4%)   21/132 (15.9%)
+  High                                                                                 
+            Not high                   19/114 (16.7%)   17/112 (15.2%)   11/115 (9.6%) 
+            High                         4/20 (20%)      6/22 (27.3%)     2/17 (11.8%) 
+            Total                      23/134 (17.2%)   23/134 (17.2%)   13/132 (9.8%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt06_cache/html/variant2_0add8624b72b5ac0d41375940c49c415">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># The following code generates one large table for multiple lab tests.</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="co"># If separate tables are needed for each lab test per GDSR standard, use the code for "single lab test".</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">count_abnormal_by_baseline</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">abnormal =</span> <span class="fu">c</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb4-12"><a href="#cb4-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">append_varlabels</span>(adlb_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 2L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">append_topleft</span>(<span class="st">"      Baseline Status"</span>)</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb4-20"><a href="#cb4-20"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">trim_rows</span>()</span>
+<span id="cb4-22"><a href="#cb4-22"></a></span>
+<span id="cb4-23"><a href="#cb4-23"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                                
+  Visit                                                                                  
+    Analysis Reference Range Indicator     A: Drug X        B: Placebo     C: Combination
+      Baseline Status                       (N=134)          (N=134)          (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                     
+  WEEK 1 DAY 8                                                                           
+    Low                                                                                  
+              Not low                    19/113 (16.8%)   13/117 (11.1%)   14/123 (11.4%)
+              Low                         2/21 (9.5%)      1/17 (5.9%)      1/9 (11.1%)  
+              Total                      21/134 (15.7%)   14/134 (10.4%)   15/132 (11.4%)
+    High                                                                                 
+              Not high                       0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+  WEEK 2 DAY 15                                                                          
+    Low                                                                                  
+              Not low                     17/113 (15%)    13/117 (11.1%)   13/123 (10.6%)
+              Low                         2/21 (9.5%)      2/17 (11.8%)     4/9 (44.4%)  
+              Total                      19/134 (14.2%)   15/134 (11.2%)   17/132 (12.9%)
+    High                                                                                 
+              Not high                       0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+  WEEK 3 DAY 22                                                                          
+    Low                                                                                  
+              Not low                    10/113 (8.8%)    20/117 (17.1%)   21/123 (17.1%)
+              Low                          4/21 (19%)      4/17 (23.5%)     2/9 (22.2%)  
+              Total                      14/134 (10.4%)   24/134 (17.9%)   23/132 (17.4%)
+    High                                                                                 
+              Not high                       0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+  WEEK 4 DAY 29                                                                          
+    Low                                                                                  
+              Not low                    15/113 (13.3%)   19/117 (16.2%)   18/123 (14.6%)
+              Low                         2/21 (9.5%)      3/17 (17.6%)     1/9 (11.1%)  
+              Total                      17/134 (12.7%)   22/134 (16.4%)   19/132 (14.4%)
+    High                                                                                 
+              Not high                       0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+  WEEK 5 DAY 36                                                                          
+    Low                                                                                  
+              Not low                     17/113 (15%)    23/117 (19.7%)   18/123 (14.6%)
+              Low                             0/21         1/17 (5.9%)      1/9 (11.1%)  
+              Total                      17/134 (12.7%)   24/134 (17.9%)   19/132 (14.4%)
+    High                                                                                 
+              Not high                       0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+C-Reactive Protein Measurement                                                           
+  WEEK 1 DAY 8                                                                           
+    Low                                                                                  
+              Not low                    16/119 (13.4%)   22/113 (19.5%)   24/112 (21.4%)
+              Low                         2/15 (13.3%)     2/21 (9.5%)       7/20 (35%)  
+              Total                      18/134 (13.4%)   24/134 (17.9%)   31/132 (23.5%)
+    High                                                                                 
+              Not high                   21/114 (18.4%)   20/112 (17.9%)   17/115 (14.8%)
+              High                         2/20 (10%)      4/22 (18.2%)     3/17 (17.6%) 
+              Total                      23/134 (17.2%)   24/134 (17.9%)   20/132 (15.2%)
+  WEEK 2 DAY 15                                                                          
+    Low                                                                                  
+              Not low                    26/119 (21.8%)   20/113 (17.7%)   12/112 (10.7%)
+              Low                         2/15 (13.3%)     3/21 (14.3%)      4/20 (20%)  
+              Total                      28/134 (20.9%)   23/134 (17.2%)   16/132 (12.1%)
+    High                                                                                 
+              Not high                   15/114 (13.2%)   17/112 (15.2%)    15/115 (13%) 
+              High                         2/20 (10%)      4/22 (18.2%)     4/17 (23.5%) 
+              Total                      17/134 (12.7%)   21/134 (15.7%)   19/132 (14.4%)
+  WEEK 3 DAY 22                                                                          
+    Low                                                                                  
+              Not low                    15/119 (12.6%)   21/113 (18.6%)   18/112 (16.1%)
+              Low                             0/15         3/21 (14.3%)         0/20     
+              Total                      15/134 (11.2%)   24/134 (17.9%)   18/132 (13.6%)
+    High                                                                                 
+              Not high                   22/114 (19.3%)   18/112 (16.1%)   17/115 (14.8%)
+              High                         2/20 (10%)      5/22 (22.7%)     1/17 (5.9%)  
+              Total                      24/134 (17.9%)   23/134 (17.2%)   18/132 (13.6%)
+  WEEK 4 DAY 29                                                                          
+    Low                                                                                  
+              Not low                    30/119 (25.2%)   13/113 (11.5%)   16/112 (14.3%)
+              Low                          3/15 (20%)      2/21 (9.5%)       5/20 (25%)  
+              Total                      33/134 (24.6%)   15/134 (11.2%)   21/132 (15.9%)
+    High                                                                                 
+              Not high                   17/114 (14.9%)   11/112 (9.8%)    16/115 (13.9%)
+              High                         2/20 (10%)      6/22 (27.3%)     3/17 (17.6%) 
+              Total                      19/134 (14.2%)   17/134 (12.7%)   19/132 (14.4%)
+  WEEK 5 DAY 36                                                                          
+    Low                                                                                  
+              Not low                    17/119 (14.3%)   19/113 (16.8%)   16/112 (14.3%)
+              Low                         2/15 (13.3%)     3/21 (14.3%)      5/20 (25%)  
+              Total                      19/134 (14.2%)   22/134 (16.4%)   21/132 (15.9%)
+    High                                                                                 
+              Not high                   19/114 (16.7%)   17/112 (15.2%)   11/115 (9.6%) 
+              High                         4/20 (20%)      6/22 (27.3%)     2/17 (11.8%) 
+              Total                      23/134 (17.2%)   23/134 (17.2%)   13/132 (9.8%) 
+Immunoglobulin A Measurement                                                             
+  WEEK 1 DAY 8                                                                           
+    Low                                                                                  
+              Not low                        0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+    High                                                                                 
+              Not high                   18/119 (15.1%)   20/116 (17.2%)   14/113 (12.4%)
+              High                        1/15 (6.7%)      5/18 (27.8%)     4/19 (21.1%) 
+              Total                      19/134 (14.2%)   25/134 (18.7%)   18/132 (13.6%)
+  WEEK 2 DAY 15                                                                          
+    Low                                                                                  
+              Not low                        0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+    High                                                                                 
+              Not high                   16/119 (13.4%)   13/116 (11.2%)   12/113 (10.6%)
+              High                        1/15 (6.7%)      1/18 (5.6%)      2/19 (10.5%) 
+              Total                      17/134 (12.7%)   14/134 (10.4%)   14/132 (10.6%)
+  WEEK 3 DAY 22                                                                          
+    Low                                                                                  
+              Not low                        0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+    High                                                                                 
+              Not high                   17/119 (14.3%)   15/116 (12.9%)   21/113 (18.6%)
+              High                            0/15         1/18 (5.6%)      1/19 (5.3%)  
+              Total                      17/134 (12.7%)   16/134 (11.9%)   22/132 (16.7%)
+  WEEK 4 DAY 29                                                                          
+    Low                                                                                  
+              Not low                        0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+    High                                                                                 
+              Not high                    19/119 (16%)    16/116 (13.8%)   19/113 (16.8%)
+              High                        4/15 (26.7%)     5/18 (27.8%)     3/19 (15.8%) 
+              Total                      23/134 (17.2%)   21/134 (15.7%)   22/132 (16.7%)
+  WEEK 5 DAY 36                                                                          
+    Low                                                                                  
+              Not low                        0/134            0/134            0/132     
+              Total                          0/134            0/134            0/132     
+    High                                                                                 
+              Not high                   16/119 (13.4%)   21/116 (18.1%)   20/113 (17.7%)
+              High                        1/15 (6.7%)      3/18 (16.7%)         0/19     
+              Total                      17/134 (12.7%)   24/134 (17.9%)   20/132 (15.2%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt06_cache/html/teal_611a7c8b8597dc6dc00f288e2d342880">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt06_cache/html/sessioninfo_b4d5cbd5f38db6702e181d3ba3fc3af8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] dplyr_1.1.3      tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt06_cache/html/snapshot_b82aa312eca97ec534db85960c8670cc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt06.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+      }
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt05.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT05</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt07.html" class="pagination-link">
+        <span class="nav-page-text">LBT07</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT06</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Abnormalities by Visit and Baseline Status</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-26"><a href="#cb10-26"></a><span class="co"># Please note that df_explict_na has a na_level argument defaulting to "&lt;Missing&gt;",</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="co"># Please don't change the na_level to anything other than NA, empty string or the default "&lt;Missing&gt;".</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a></span>
+<span id="cb10-29"><a href="#cb10-29"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(<span class="sc">!</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">var_relabel</span>(<span class="at">AVISIT =</span> <span class="st">"Visit"</span>)</span>
+<span id="cb10-34"><a href="#cb10-34"></a></span>
+<span id="cb10-35"><a href="#cb10-35"></a>adlb_f_crp <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span>)</span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="in">```</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="fu">## Standard Table for &lt;br/&gt; Single Lab Test</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a><span class="co"># Define the split function</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-43"><a href="#cb10-43"></a></span>
+<span id="cb10-44"><a href="#cb10-44"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f_crp<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>  <span class="fu">count_abnormal_by_baseline</span>(</span>
+<span id="cb10-48"><a href="#cb10-48"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">abnormal =</span> <span class="fu">c</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="fu">append_varlabels</span>(adlb_f_crp, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L) <span class="sc">%&gt;%</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Baseline Status"</span>)</span>
+<span id="cb10-54"><a href="#cb10-54"></a></span>
+<span id="cb10-55"><a href="#cb10-55"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="at">df =</span> adlb_f_crp,</span>
+<span id="cb10-58"><a href="#cb10-58"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-59"><a href="#cb10-59"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="fu">trim_rows</span>()</span>
+<span id="cb10-61"><a href="#cb10-61"></a></span>
+<span id="cb10-62"><a href="#cb10-62"></a>result</span>
+<span id="cb10-63"><a href="#cb10-63"></a><span class="in">```</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="fu">## Standard Table for &lt;br/&gt; Multiple Lab Tests</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a></span>
+<span id="cb10-67"><a href="#cb10-67"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="co"># The following code generates one large table for multiple lab tests.</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a><span class="co"># If separate tables are needed for each lab test per GDSR standard, use the code for "single lab test".</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a></span>
+<span id="cb10-71"><a href="#cb10-71"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>AVISIT)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>  <span class="fu">count_abnormal_by_baseline</span>(</span>
+<span id="cb10-76"><a href="#cb10-76"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>    <span class="at">abnormal =</span> <span class="fu">c</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb10-79"><a href="#cb10-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>  <span class="fu">append_varlabels</span>(adlb_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 2L) <span class="sc">%&gt;%</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a>  <span class="fu">append_topleft</span>(<span class="st">"      Baseline Status"</span>)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  <span class="at">lyt =</span> lyt,</span>
+<span id="cb10-85"><a href="#cb10-85"></a>  <span class="at">df =</span> adlb_f,</span>
+<span id="cb10-86"><a href="#cb10-86"></a>  <span class="at">alt_counts_df =</span> adsl</span>
+<span id="cb10-87"><a href="#cb10-87"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-88"><a href="#cb10-88"></a>  <span class="fu">trim_rows</span>()</span>
+<span id="cb10-89"><a href="#cb10-89"></a></span>
+<span id="cb10-90"><a href="#cb10-90"></a>result</span>
+<span id="cb10-91"><a href="#cb10-91"></a><span class="in">```</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a></span>
+<span id="cb10-93"><a href="#cb10-93"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-94"><a href="#cb10-94"></a></span>
+<span id="cb10-95"><a href="#cb10-95"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="co"># In progress</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a><span class="in">```</span></span>
+<span id="cb10-102"><a href="#cb10-102"></a></span>
+<span id="cb10-103"><a href="#cb10-103"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-104"><a href="#cb10-104"></a></span>
+<span id="cb10-105"><a href="#cb10-105"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+</style>
+
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+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT07</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results with Highest NCI CTCAE Grade Post-Baseline</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt07_cache/html/setup_c37b6db0ce10934ac0c997eee9a5109e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adlb_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="co"># Select worst post-baseline records.</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">filter</span>(ATOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">|</span> WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a><span class="fu">var_labels</span>(adlb_f) <span class="ot">&lt;-</span> adlb_labels</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># Derive GRADE_DIR and GRADE_ANL to use in layout from ATOXGR</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>adlb_f <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">GRADE_DIR =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-28"><a href="#cb1-28"></a>        ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>) <span class="sc">&amp;</span> .data<span class="sc">$</span>WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>        ATOXGR <span class="sc">==</span> <span class="st">"0"</span> <span class="sc">~</span> <span class="st">"ZERO"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>        ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>) <span class="sc">&amp;</span> .data<span class="sc">$</span>WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"HIGH"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NONE"</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>      ),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"ZERO"</span>, <span class="st">"HIGH"</span>, <span class="st">"NONE"</span>)</span>
+<span id="cb1-34"><a href="#cb1-34"></a>    ),</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">GRADE_ANL =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      forcats<span class="sc">::</span><span class="fu">fct_recode</span>(ATOXGR,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">`</span><span class="at">1</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-1"</span>, <span class="st">`</span><span class="at">2</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-2"</span>, <span class="st">`</span><span class="at">3</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-3"</span>, <span class="st">`</span><span class="at">4</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-4"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>      ),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      <span class="fu">c</span>(<span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    )</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-42"><a href="#cb1-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-43"><a href="#cb1-43"></a>    <span class="at">GRADE_DIR =</span> <span class="st">"Direction of Abnormality"</span>,</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">GRADE_ANL =</span> <span class="st">"Analysis Grade"</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  )</span>
+<span id="cb1-46"><a href="#cb1-46"></a></span>
+<span id="cb1-47"><a href="#cb1-47"></a><span class="co"># Construct analysis map</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>map <span class="ot">&lt;-</span> <span class="fu">expand.grid</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="at">PARAM =</span> <span class="fu">levels</span>(adlb<span class="sc">$</span>PARAM),</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="at">GRADE_DIR =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"HIGH"</span>),</span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="at">GRADE_ANL =</span> <span class="fu">as.character</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">4</span>),</span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-54"><a href="#cb1-54"></a>  <span class="fu">arrange</span>(PARAM, <span class="fu">desc</span>(GRADE_DIR), GRADE_ANL)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt07_cache/html/variant1_138eb4554e002b3c32d9905f8ae9283e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">required =</span> <span class="st">"ATOXGR"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">.stats =</span> <span class="st">"unique_count"</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="st">"GRADE_DIR"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>GRADE_DIR),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">count_abnormal_by_worst_grade</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">var =</span> <span class="st">"GRADE_ANL"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">grade_dir =</span> <span class="st">"GRADE_DIR"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">append_topleft</span>(<span class="st">"            Highest NCI CTCAE Grade"</span>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a></span>
+<span id="cb2-26"><a href="#cb2-26"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-27"><a href="#cb2-27"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb2-28"><a href="#cb2-28"></a></span>
+<span id="cb2-29"><a href="#cb2-29"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                          
+  Direction of Abnormality                 A: Drug X    B: Placebo   C: Combination
+            Highest NCI CTCAE Grade         (N=134)      (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement (n)      134          134            132      
+  LOW                                                                              
+            1                              15 (11.2%)   11 (8.2%)      15 (11.4%)  
+            2                              18 (13.4%)   24 (17.9%)     17 (12.9%)  
+            3                              16 (11.9%)   24 (17.9%)     16 (12.1%)  
+            4                              17 (12.7%)   10 (7.5%)      18 (13.6%)  
+            Any                            66 (49.3%)   69 (51.5%)      66 (50%)   
+C-Reactive Protein Measurement (n)            134          134            132      
+  LOW                                                                              
+            1                              21 (15.7%)   22 (16.4%)     12 (9.1%)   
+            2                              24 (17.9%)   22 (16.4%)     18 (13.6%)  
+            3                              29 (21.6%)   21 (15.7%)     25 (18.9%)  
+            4                              10 (7.5%)    16 (11.9%)     22 (16.7%)  
+            Any                            84 (62.7%)   81 (60.4%)     77 (58.3%)  
+  HIGH                                                                             
+            1                              20 (14.9%)   22 (16.4%)     22 (16.7%)  
+            2                              21 (15.7%)   15 (11.2%)     14 (10.6%)  
+            3                              25 (18.7%)   16 (11.9%)     20 (15.2%)  
+            4                              13 (9.7%)    20 (14.9%)     11 (8.3%)   
+            Any                             79 (59%)    73 (54.5%)     67 (50.8%)  
+Immunoglobulin A Measurement (n)              134          134            132      
+  HIGH                                                                             
+            1                              19 (14.2%)    12 (9%)       18 (13.6%)  
+            2                              17 (12.7%)   24 (17.9%)     19 (14.4%)  
+            3                              21 (15.7%)   23 (17.2%)     23 (17.4%)  
+            4                              13 (9.7%)    13 (9.7%)       9 (6.8%)   
+            Any                            70 (52.2%)   72 (53.7%)     69 (52.3%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="lbt07_cache/html/teal_da1c111cf67e3aa1fa1f13259e50d810">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">filter</span>(<span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>))</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a><span class="st">    filter(!AVISIT %in% c("SCREENING", "BASELINE"))'</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>    ),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ),</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="fu">tm_t_abnormality_by_worst_grade</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results with Highest Grade Post-Baseline"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-24"><a href="#cb4-24"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a>      ),</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-27"><a href="#cb4-27"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-28"><a href="#cb4-28"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ALT"</span>, <span class="st">"CRP"</span>, <span class="st">"IGA"</span>)</span>
+<span id="cb4-29"><a href="#cb4-29"></a>      ),</span>
+<span id="cb4-30"><a href="#cb4-30"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>    )</span>
+<span id="cb4-32"><a href="#cb4-32"></a>  ),</span>
+<span id="cb4-33"><a href="#cb4-33"></a>  <span class="at">filter =</span> (</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="fu">list</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">ONTRTFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    )</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  )</span>
+<span id="cb4-39"><a href="#cb4-39"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:28:45.3840 pid:12387 token:[] teal.modules.clinical Initializing tm_t_abnormality_by_worst_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt07_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt07_cache/html/sessioninfo_a85496998832bc8a924fadfa87ce4cb3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] forcats_1.0.0                dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt07_cache/html/snapshot_1564b79eadf7c01c70d067bf790dd25f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt07.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
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+      bodyEl.classList.remove("quarto-light");
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT07</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results with Highest NCI CTCAE Grade Post-Baseline</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb10-20"><a href="#cb10-20"></a></span>
+<span id="cb10-21"><a href="#cb10-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb10-23"><a href="#cb10-23"></a></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adlb_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adlb)</span>
+<span id="cb10-25"><a href="#cb10-25"></a></span>
+<span id="cb10-26"><a href="#cb10-26"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-28"><a href="#cb10-28"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a><span class="co"># Select worst post-baseline records.</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  <span class="fu">filter</span>(ATOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>  <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">|</span> WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-35"><a href="#cb10-35"></a></span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="fu">var_labels</span>(adlb_f) <span class="ot">&lt;-</span> adlb_labels</span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="co"># Derive GRADE_DIR and GRADE_ANL to use in layout from ATOXGR</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>adlb_f <span class="ot">&lt;-</span> adlb_f <span class="sc">%&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">GRADE_DIR =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb10-43"><a href="#cb10-43"></a>        ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>) <span class="sc">&amp;</span> .data<span class="sc">$</span>WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"LOW"</span>,</span>
+<span id="cb10-44"><a href="#cb10-44"></a>        ATOXGR <span class="sc">==</span> <span class="st">"0"</span> <span class="sc">~</span> <span class="st">"ZERO"</span>,</span>
+<span id="cb10-45"><a href="#cb10-45"></a>        ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>) <span class="sc">&amp;</span> .data<span class="sc">$</span>WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"HIGH"</span>,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"NONE"</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>      ),</span>
+<span id="cb10-48"><a href="#cb10-48"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"ZERO"</span>, <span class="st">"HIGH"</span>, <span class="st">"NONE"</span>)</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    ),</span>
+<span id="cb10-50"><a href="#cb10-50"></a>    <span class="at">GRADE_ANL =</span> forcats<span class="sc">::</span><span class="fu">fct_relevel</span>(</span>
+<span id="cb10-51"><a href="#cb10-51"></a>      forcats<span class="sc">::</span><span class="fu">fct_recode</span>(ATOXGR,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>        <span class="st">`</span><span class="at">1</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-1"</span>, <span class="st">`</span><span class="at">2</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-2"</span>, <span class="st">`</span><span class="at">3</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-3"</span>, <span class="st">`</span><span class="at">4</span><span class="st">`</span> <span class="ot">=</span> <span class="st">"-4"</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>      ),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>      <span class="fu">c</span>(<span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb10-55"><a href="#cb10-55"></a>    )</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb10-58"><a href="#cb10-58"></a>    <span class="at">GRADE_DIR =</span> <span class="st">"Direction of Abnormality"</span>,</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="at">GRADE_ANL =</span> <span class="st">"Analysis Grade"</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  )</span>
+<span id="cb10-61"><a href="#cb10-61"></a></span>
+<span id="cb10-62"><a href="#cb10-62"></a><span class="co"># Construct analysis map</span></span>
+<span id="cb10-63"><a href="#cb10-63"></a>map <span class="ot">&lt;-</span> <span class="fu">expand.grid</span>(</span>
+<span id="cb10-64"><a href="#cb10-64"></a>  <span class="at">PARAM =</span> <span class="fu">levels</span>(adlb<span class="sc">$</span>PARAM),</span>
+<span id="cb10-65"><a href="#cb10-65"></a>  <span class="at">GRADE_DIR =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"HIGH"</span>),</span>
+<span id="cb10-66"><a href="#cb10-66"></a>  <span class="at">GRADE_ANL =</span> <span class="fu">as.character</span>(<span class="dv">1</span><span class="sc">:</span><span class="dv">4</span>),</span>
+<span id="cb10-67"><a href="#cb10-67"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a>  <span class="fu">arrange</span>(PARAM, <span class="fu">desc</span>(GRADE_DIR), GRADE_ANL)</span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="in">```</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a></span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-77"><a href="#cb10-77"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-80"><a href="#cb10-80"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>PARAM)</span>
+<span id="cb10-81"><a href="#cb10-81"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-82"><a href="#cb10-82"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb10-83"><a href="#cb10-83"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb10-84"><a href="#cb10-84"></a>    <span class="at">required =</span> <span class="st">"ATOXGR"</span>,</span>
+<span id="cb10-85"><a href="#cb10-85"></a>    <span class="at">.stats =</span> <span class="st">"unique_count"</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-88"><a href="#cb10-88"></a>    <span class="st">"GRADE_DIR"</span>,</span>
+<span id="cb10-89"><a href="#cb10-89"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-90"><a href="#cb10-90"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_f<span class="sc">$</span>GRADE_DIR),</span>
+<span id="cb10-91"><a href="#cb10-91"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map)</span>
+<span id="cb10-92"><a href="#cb10-92"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-93"><a href="#cb10-93"></a>  <span class="fu">count_abnormal_by_worst_grade</span>(</span>
+<span id="cb10-94"><a href="#cb10-94"></a>    <span class="at">var =</span> <span class="st">"GRADE_ANL"</span>,</span>
+<span id="cb10-95"><a href="#cb10-95"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">param =</span> <span class="st">"PARAM"</span>, <span class="at">grade_dir =</span> <span class="st">"GRADE_DIR"</span>),</span>
+<span id="cb10-96"><a href="#cb10-96"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb10-97"><a href="#cb10-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  <span class="fu">append_topleft</span>(<span class="st">"            Highest NCI CTCAE Grade"</span>)</span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> adlb_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-101"><a href="#cb10-101"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">prune_table</span>()</span>
+<span id="cb10-102"><a href="#cb10-102"></a></span>
+<span id="cb10-103"><a href="#cb10-103"></a>result</span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="in">```</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a></span>
+<span id="cb10-106"><a href="#cb10-106"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-107"><a href="#cb10-107"></a></span>
+<span id="cb10-108"><a href="#cb10-108"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a></span>
+<span id="cb10-110"><a href="#cb10-110"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-111"><a href="#cb10-111"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb10-112"><a href="#cb10-112"></a></span>
+<span id="cb10-113"><a href="#cb10-113"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-114"><a href="#cb10-114"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-115"><a href="#cb10-115"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-116"><a href="#cb10-116"></a></span>
+<span id="cb10-117"><a href="#cb10-117"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-118"><a href="#cb10-118"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-119"><a href="#cb10-119"></a>  <span class="fu">filter</span>(<span class="sc">!</span>AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>))</span>
+<span id="cb10-120"><a href="#cb10-120"></a></span>
+<span id="cb10-121"><a href="#cb10-121"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-122"><a href="#cb10-122"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-123"><a href="#cb10-123"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-124"><a href="#cb10-124"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb10-125"><a href="#cb10-125"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb10-126"><a href="#cb10-126"></a><span class="st">    filter(!AVISIT %in% c("SCREENING", "BASELINE"))'</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a>    ),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a>  ),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-131"><a href="#cb10-131"></a>    <span class="fu">tm_t_abnormality_by_worst_grade</span>(</span>
+<span id="cb10-132"><a href="#cb10-132"></a>      <span class="at">label =</span> <span class="st">"Laboratory Test Results with Highest Grade Post-Baseline"</span>,</span>
+<span id="cb10-133"><a href="#cb10-133"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb10-134"><a href="#cb10-134"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-135"><a href="#cb10-135"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-136"><a href="#cb10-136"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-137"><a href="#cb10-137"></a>      ),</span>
+<span id="cb10-138"><a href="#cb10-138"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-139"><a href="#cb10-139"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-140"><a href="#cb10-140"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ALT"</span>, <span class="st">"CRP"</span>, <span class="st">"IGA"</span>)</span>
+<span id="cb10-141"><a href="#cb10-141"></a>      ),</span>
+<span id="cb10-142"><a href="#cb10-142"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-143"><a href="#cb10-143"></a>    )</span>
+<span id="cb10-144"><a href="#cb10-144"></a>  ),</span>
+<span id="cb10-145"><a href="#cb10-145"></a>  <span class="at">filter =</span> (</span>
+<span id="cb10-146"><a href="#cb10-146"></a>    <span class="fu">list</span>(</span>
+<span id="cb10-147"><a href="#cb10-147"></a>      <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>),</span>
+<span id="cb10-148"><a href="#cb10-148"></a>      <span class="at">ADLB =</span> <span class="fu">list</span>(<span class="at">ONTRTFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-149"><a href="#cb10-149"></a>    )</span>
+<span id="cb10-150"><a href="#cb10-150"></a>  )</span>
+<span id="cb10-151"><a href="#cb10-151"></a>)</span>
+<span id="cb10-152"><a href="#cb10-152"></a></span>
+<span id="cb10-153"><a href="#cb10-153"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-154"><a href="#cb10-154"></a><span class="in">```</span></span>
+<span id="cb10-155"><a href="#cb10-155"></a></span>
+<span id="cb10-156"><a href="#cb10-156"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-157"><a href="#cb10-157"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
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+
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT08</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results with Highest NCI CTCAE Grade at Any Time</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt08_cache/html/setup_d4cfbf57ebe5a406cfe6f74b90613d87">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="at">GRADDR =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>      PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb1-12"><a href="#cb1-12"></a>      PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">~</span> <span class="st">"B"</span>,</span>
+<span id="cb1-13"><a href="#cb1-13"></a>      PARAMCD <span class="sc">==</span> <span class="st">"IGA"</span> <span class="sc">~</span> <span class="st">"H"</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>    )</span>
+<span id="cb1-15"><a href="#cb1-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> GRADDR <span class="sc">!=</span> <span class="st">""</span>)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-19"><a href="#cb1-19"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a>df <span class="ot">&lt;-</span> <span class="fu">h_adlb_worsen</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  adlb,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="at">worst_flag_low =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="at">worst_flag_high =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="at">direction_var =</span> <span class="st">"GRADDR"</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>)</span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="fu">attributes</span>(df<span class="sc">$</span>GRADDR) <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="st">"label"</span> <span class="ot">=</span> <span class="st">"Direction of Abnormality"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>Note: The direction of the shift table for each lab test is based on metadata and NCI CTCAE specifications. In addition, the worst laboratory flags must be selected appropriately to match the direction of abnormality. For example, if any lab requires a shift table for both directions, then both <code>worst_flag_low</code> and <code>worst_flag_high</code> must be specified in <code>h_adlb_worsen</code>. If all labs requires a shift table for only one direction, then the matching worst lab flag variable must be selected in <code>h_adlb_worsen</code>.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt08_cache/html/variant1_5aca3af40ba35ab196703e842954ed58">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCD"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>PARAMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"GRADDR"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>GRADDR)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">count_abnormal_lab_worsen_by_baseline</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">var =</span> <span class="st">"ATOXGR"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>      <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>      <span class="at">baseline_var =</span> <span class="st">"BTOXGR"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      <span class="at">direction_var =</span> <span class="st">"GRADDR"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>    )</span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Highest NCI CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-15"><a href="#cb2-15"></a></span>
+<span id="cb2-16"><a href="#cb2-16"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                                
+  Direction of Abnormality        ARM A            ARM B            ARM C     
+    Highest NCI CTCAE Grade      (N=134)          (N=134)          (N=132)    
+——————————————————————————————————————————————————————————————————————————————
+ALT                                                                           
+  Low                                                                         
+    1                         11/113 (9.7%)     9/117 (7.7%)    15/123 (12.2%)
+    2                         15/119 (12.6%)   23/123 (18.7%)   16/127 (12.6%)
+    3                         15/127 (11.8%)   22/128 (17.2%)   14/128 (10.9%)
+    4                         17/130 (13.1%)   10/131 (7.6%)    18/130 (13.8%)
+    Any                       58/130 (44.6%)   64/131 (48.9%)   63/130 (48.5%)
+CRP                                                                           
+  High                                                                        
+    1                         18/114 (15.8%)   18/112 (16.1%)   19/115 (16.5%)
+    2                         20/122 (16.4%)   13/122 (10.7%)   14/122 (11.5%)
+    3                         23/124 (18.5%)   14/128 (10.9%)   20/129 (15.5%)
+    4                         12/131 (9.2%)    20/132 (15.2%)   11/132 (8.3%) 
+    Any                       73/131 (55.7%)   65/132 (49.2%)   64/132 (48.5%)
+  Low                                                                         
+    1                         20/119 (16.8%)   18/113 (15.9%)   11/112 (9.8%) 
+    2                         24/122 (19.7%)   21/118 (17.8%)    17/121 (14%) 
+    3                         26/127 (20.5%)   20/127 (15.7%)   22/123 (17.9%)
+    4                         10/131 (7.6%)    16/132 (12.1%)   21/130 (16.2%)
+    Any                       80/131 (61.1%)   75/132 (56.8%)   71/130 (54.6%)
+IGA                                                                           
+  High                                                                        
+    1                         18/119 (15.1%)   11/116 (9.5%)    15/113 (13.3%)
+    2                         15/124 (12.1%)   23/120 (19.2%)   19/115 (16.5%)
+    3                         21/128 (16.4%)   21/124 (16.9%)   20/120 (16.7%)
+    4                         12/132 (9.1%)    12/129 (9.3%)     9/131 (6.9%) 
+    Any                        66/132 (50%)    67/129 (51.9%)   63/131 (48.1%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt08_cache/html/teal_9eeb12dbab97158740b83113edd3cb0d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt08_cache/html/sessioninfo_d2d9cc7886d5da8488b55f232575e09d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt08_cache/html/snapshot_74ad32b9c679990fa61b99d62f1bd42c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt08.lock">Download</a></p>
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt07.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT07</span>
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+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt09.html" class="pagination-link">
+        <span class="nav-page-text">LBT09</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> LBT08</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results with Highest NCI CTCAE Grade at Any Time</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a></span>
+<span id="cb8-23"><a href="#cb8-23"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    <span class="at">GRADDR =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>      PARAMCD <span class="sc">==</span> <span class="st">"ALT"</span> <span class="sc">~</span> <span class="st">"L"</span>,</span>
+<span id="cb8-27"><a href="#cb8-27"></a>      PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">~</span> <span class="st">"B"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>      PARAMCD <span class="sc">==</span> <span class="st">"IGA"</span> <span class="sc">~</span> <span class="st">"H"</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>    )</span>
+<span id="cb8-30"><a href="#cb8-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> GRADDR <span class="sc">!=</span> <span class="st">""</span>)</span>
+<span id="cb8-32"><a href="#cb8-32"></a></span>
+<span id="cb8-33"><a href="#cb8-33"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-34"><a href="#cb8-34"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb8-35"><a href="#cb8-35"></a></span>
+<span id="cb8-36"><a href="#cb8-36"></a>df <span class="ot">&lt;-</span> <span class="fu">h_adlb_worsen</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>  adlb,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>  <span class="at">worst_flag_low =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>  <span class="at">worst_flag_high =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="at">direction_var =</span> <span class="st">"GRADDR"</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>)</span>
+<span id="cb8-42"><a href="#cb8-42"></a></span>
+<span id="cb8-43"><a href="#cb8-43"></a><span class="fu">attributes</span>(df<span class="sc">$</span>GRADDR) <span class="ot">&lt;-</span> <span class="fu">list</span>(<span class="st">"label"</span> <span class="ot">=</span> <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb8-44"><a href="#cb8-44"></a><span class="in">```</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a></span>
+<span id="cb8-46"><a href="#cb8-46"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>Note: The direction of the shift table for each lab test is based on metadata and NCI CTCAE specifications.</span>
+<span id="cb8-49"><a href="#cb8-49"></a>In addition, the worst laboratory flags must be selected appropriately to match the direction of abnormality.</span>
+<span id="cb8-50"><a href="#cb8-50"></a>For example, if any lab requires a shift table for both directions, then both <span class="in">`worst_flag_low`</span> and <span class="in">`worst_flag_high`</span> must be specified in <span class="in">`h_adlb_worsen`</span>.</span>
+<span id="cb8-51"><a href="#cb8-51"></a>If all labs requires a shift table for only one direction, then the matching worst lab flag variable must be selected in <span class="in">`h_adlb_worsen`</span>.</span>
+<span id="cb8-52"><a href="#cb8-52"></a></span>
+<span id="cb8-53"><a href="#cb8-53"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCD"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>PARAMCD)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">split_rows_by</span>(<span class="st">"GRADDR"</span>, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(df<span class="sc">$</span>GRADDR)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  <span class="fu">count_abnormal_lab_worsen_by_baseline</span>(</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="at">var =</span> <span class="st">"ATOXGR"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">variables =</span> <span class="fu">list</span>(</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      <span class="at">id =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-62"><a href="#cb8-62"></a>      <span class="at">baseline_var =</span> <span class="st">"BTOXGR"</span>,</span>
+<span id="cb8-63"><a href="#cb8-63"></a>      <span class="at">direction_var =</span> <span class="st">"GRADDR"</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>    )</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-66"><a href="#cb8-66"></a>  <span class="fu">append_topleft</span>(<span class="st">"    Highest NCI CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-67"><a href="#cb8-67"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> df, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-68"><a href="#cb8-68"></a></span>
+<span id="cb8-69"><a href="#cb8-69"></a>result</span>
+<span id="cb8-70"><a href="#cb8-70"></a><span class="in">```</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a></span>
+<span id="cb8-72"><a href="#cb8-72"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-73"><a href="#cb8-73"></a></span>
+<span id="cb8-74"><a href="#cb8-74"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-75"><a href="#cb8-75"></a></span>
+<span id="cb8-76"><a href="#cb8-76"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a></span>
+<span id="cb8-79"><a href="#cb8-79"></a><span class="co"># In progress</span></span>
+<span id="cb8-80"><a href="#cb8-80"></a><span class="in">```</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a></span>
+<span id="cb8-82"><a href="#cb8-82"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-83"><a href="#cb8-83"></a></span>
+<span id="cb8-84"><a href="#cb8-84"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+  <div class="sidebar-item-container"> 
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT09</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting Sections</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt09_cache/html/setup_feb62d9c79d3c9cc59c94e96b135e45d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adhy_liver <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy)</span>
+<span id="cb1-9"><a href="#cb1-9"></a></span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="co"># Define values of interest in PARAMCD variable.</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>paramcd_tbili_alt <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"BLAL"</span>, <span class="st">"BGAL"</span>, <span class="st">"BA2AL"</span>, <span class="st">"BA5AL"</span>)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>paramcd_tbili_ast <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"BLAS"</span>, <span class="st">"BGAS"</span>, <span class="st">"BA2AS"</span>, <span class="st">"BA5AS"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a><span class="co"># Select LBT09 parameters.</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"POST-BASELINE"</span>),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt, paramcd_tbili_ast)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  )</span>
+<span id="cb1-21"><a href="#cb1-21"></a></span>
+<span id="cb1-22"><a href="#cb1-22"></a><span class="co"># Let's be explicit about factor levels for AVISIT and PARAMCD.</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">AVISIT =</span> <span class="fu">factor</span>(AVISIT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"POST-BASELINE"</span>)),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">PARAMCD =</span> <span class="fu">factor</span>(PARAMCD, <span class="at">levels =</span> <span class="fu">c</span>(paramcd_tbili_alt, paramcd_tbili_ast))</span>
+<span id="cb1-27"><a href="#cb1-27"></a>  )</span>
+<span id="cb1-28"><a href="#cb1-28"></a></span>
+<span id="cb1-29"><a href="#cb1-29"></a><span class="co"># Create indicator and category variables.</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">TBILI_CAT =</span> <span class="fu">factor</span>( <span class="co"># Create TBILI_CAT categories variable - this is needed so we get the right nesting in the table.</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">1</span>], paramcd_tbili_ast[<span class="dv">1</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">2</span>], paramcd_tbili_ast[<span class="dv">2</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">3</span>], paramcd_tbili_ast[<span class="dv">3</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">4</span>], paramcd_tbili_ast[<span class="dv">4</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>      ),</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-40"><a href="#cb1-40"></a>        <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>        <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb1-42"><a href="#cb1-42"></a>        <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb1-43"><a href="#cb1-43"></a>        <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>      )</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    ),</span>
+<span id="cb1-46"><a href="#cb1-46"></a>    <span class="at">ALTAST_CAT =</span> <span class="fu">factor</span>( <span class="co"># Create ALTAST_CAT categories variable - this will be the labels for different ALT/AST categories displayed in the table.</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-48"><a href="#cb1-48"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;3-5ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>,</span>
+<span id="cb1-49"><a href="#cb1-49"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;5-10ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;10-20ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb1-51"><a href="#cb1-51"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;20ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt; 20xULN"</span>,</span>
+<span id="cb1-52"><a href="#cb1-52"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;3-5ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>,</span>
+<span id="cb1-53"><a href="#cb1-53"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;5-10ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>,</span>
+<span id="cb1-54"><a href="#cb1-54"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;10-20ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;20ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt; 20xULN"</span>,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb1-57"><a href="#cb1-57"></a>      ),</span>
+<span id="cb1-58"><a href="#cb1-58"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-59"><a href="#cb1-59"></a>        <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>, <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>, <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb1-60"><a href="#cb1-60"></a>        <span class="st">"20"</span> <span class="ot">=</span> <span class="st">"ALT &gt; 20xULN"</span>,</span>
+<span id="cb1-61"><a href="#cb1-61"></a>        <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>, <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>, <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>, <span class="st">"AST &gt; 20xULN"</span>,</span>
+<span id="cb1-62"><a href="#cb1-62"></a>        <span class="st">"Criteria not met"</span></span>
+<span id="cb1-63"><a href="#cb1-63"></a>      )</span>
+<span id="cb1-64"><a href="#cb1-64"></a>    ),</span>
+<span id="cb1-65"><a href="#cb1-65"></a>    <span class="at">ALTAST_ind =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-66"><a href="#cb1-66"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-67"><a href="#cb1-67"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">~</span> <span class="st">"ALT"</span>,</span>
+<span id="cb1-68"><a href="#cb1-68"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">~</span> <span class="st">"AST"</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a>      ),</span>
+<span id="cb1-70"><a href="#cb1-70"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ALT"</span>, <span class="st">"AST"</span>)</span>
+<span id="cb1-71"><a href="#cb1-71"></a>    )</span>
+<span id="cb1-72"><a href="#cb1-72"></a>  )</span>
+<span id="cb1-73"><a href="#cb1-73"></a></span>
+<span id="cb1-74"><a href="#cb1-74"></a>map <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb1-75"><a href="#cb1-75"></a>  <span class="at">ALTAST_ind =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"ALT"</span>, <span class="dv">5</span>), <span class="fu">rep</span>(<span class="st">"AST"</span>, <span class="dv">5</span>)),</span>
+<span id="cb1-76"><a href="#cb1-76"></a>  <span class="at">ALTAST_CAT =</span> <span class="fu">c</span>(</span>
+<span id="cb1-77"><a href="#cb1-77"></a>    <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>, <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>, <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb1-78"><a href="#cb1-78"></a>    <span class="st">"20"</span> <span class="ot">=</span> <span class="st">"ALT &gt; 20xULN"</span>, <span class="st">"Criteria not met"</span>,</span>
+<span id="cb1-79"><a href="#cb1-79"></a>    <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>, <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>, <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>, <span class="st">"AST &gt; 20xULN"</span>, <span class="st">"Criteria not met"</span></span>
+<span id="cb1-80"><a href="#cb1-80"></a>  ),</span>
+<span id="cb1-81"><a href="#cb1-81"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-82"><a href="#cb1-82"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt09_cache/html/variant1_dcc4eec070c5e64f24b35f1f2fb68f21">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"TBILI_CAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="co"># below split helps us get the right denominator between ALT/AST but it can be hidden</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ALTAST_ind"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">vars =</span> <span class="st">"ALTAST_CAT"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">.stats =</span> <span class="st">"fraction"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  <span class="fu">append_topleft</span>(<span class="st">"Liver Laboratory Test Criterion"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adhy_liver)</span>
+<span id="cb2-15"><a href="#cb2-15"></a></span>
+<span id="cb2-16"><a href="#cb2-16"></a><span class="co"># trim away rows with criteria not met</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb2-18"><a href="#cb2-18"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb2-20"><a href="#cb2-20"></a>}</span>
+<span id="cb2-21"><a href="#cb2-21"></a></span>
+<span id="cb2-22"><a href="#cb2-22"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-23"><a href="#cb2-23"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Liver Laboratory Test Criterion                                        A: Drug X                        B: Placebo                      C: Combination         
+                                                               BASELINE      POST-BASELINE       BASELINE      POST-BASELINE       BASELINE      POST-BASELINE 
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                                                                                                       
+  ALT &gt;3 - &lt;= 5xULN                                         23/134 (17.2%)   15/134 (11.2%)   25/134 (18.7%)   27/134 (20.1%)   27/132 (20.5%)   30/132 (22.7%)
+  ALT &gt;5 - &lt;= 10xULN                                        28/134 (20.9%)   29/134 (21.6%)   29/134 (21.6%)   19/134 (14.2%)   36/132 (27.3%)   29/132 (22.0%)
+  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   30/134 (22.4%)   32/134 (23.9%)   33/134 (24.6%)   28/132 (21.2%)   24/132 (18.2%)
+  ALT &gt; 20xULN                                              32/134 (23.9%)   35/134 (26.1%)   24/134 (17.9%)   23/134 (17.2%)   20/132 (15.2%)   26/132 (19.7%)
+  AST &gt;3 - &lt;= 5xULN                                         31/134 (23.1%)   34/134 (25.4%)   30/134 (22.4%)   26/134 (19.4%)   34/132 (25.8%)   24/132 (18.2%)
+  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   25/134 (18.7%)   26/134 (19.4%)   26/134 (19.4%)   22/132 (16.7%)   27/132 (20.5%)
+  AST &gt;10 - &lt;= 20xULN                                       22/134 (16.4%)   29/134 (21.6%)   16/134 (11.9%)   22/134 (16.4%)   34/132 (25.8%)   19/132 (14.4%)
+  AST &gt; 20xULN                                              20/134 (14.9%)   16/134 (11.9%)   28/134 (20.9%)   31/134 (23.1%)   21/132 (15.9%)   39/132 (29.5%)
+Total Bilirubin &gt; 2xULN                                                                                                                                        
+  ALT &gt;3 - &lt;= 5xULN                                         40/134 (29.9%)   28/134 (20.9%)   31/134 (23.1%)   28/134 (20.9%)   18/132 (13.6%)   32/132 (24.2%)
+  ALT &gt;5 - &lt;= 10xULN                                        24/134 (17.9%)   29/134 (21.6%)   30/134 (22.4%)   37/134 (27.6%)   33/132 (25.0%)   24/132 (18.2%)
+  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   22/134 (16.4%)   26/134 (19.4%)   18/134 (13.4%)   21/132 (15.9%)   30/132 (22.7%)
+  ALT &gt; 20xULN                                              19/134 (14.2%)   33/134 (24.6%)   23/134 (17.2%)   19/134 (14.2%)   30/132 (22.7%)   22/132 (16.7%)
+  AST &gt;3 - &lt;= 5xULN                                         17/134 (12.7%)   27/134 (20.1%)   36/134 (26.9%)   25/134 (18.7%)   26/132 (19.7%)   34/132 (25.8%)
+  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   28/134 (20.9%)   24/134 (17.9%)   28/134 (20.9%)   20/132 (15.2%)   23/132 (17.4%)
+  AST &gt;10 - &lt;= 20xULN                                       36/134 (26.9%)   28/134 (20.9%)   16/134 (11.9%)   26/134 (19.4%)   33/132 (25.0%)   26/132 (19.7%)
+  AST &gt; 20xULN                                              30/134 (22.4%)   21/134 (15.7%)   30/134 (22.4%)   24/134 (17.9%)   24/132 (18.2%)   25/132 (18.9%)
+Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN                                                                                                      
+  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   22/134 (16.4%)   28/134 (20.9%)   23/134 (17.2%)   38/132 (28.8%)   23/132 (17.4%)
+  ALT &gt;5 - &lt;= 10xULN                                        26/134 (19.4%)   25/134 (18.7%)   19/134 (14.2%)   22/134 (16.4%)   32/132 (24.2%)   32/132 (24.2%)
+  ALT &gt;10 - &lt;= 20xULN                                       26/134 (19.4%)   30/134 (22.4%)   31/134 (23.1%)   30/134 (22.4%)   21/132 (15.9%)   27/132 (20.5%)
+  ALT &gt; 20xULN                                              30/134 (22.4%)   28/134 (20.9%)   24/134 (17.9%)   36/134 (26.9%)   20/132 (15.2%)   23/132 (17.4%)
+  AST &gt;3 - &lt;= 5xULN                                         37/134 (27.6%)   25/134 (18.7%)   31/134 (23.1%)   26/134 (19.4%)   24/132 (18.2%)   36/132 (27.3%)
+  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   32/134 (23.9%)   29/134 (21.6%)   30/134 (22.4%)   26/132 (19.7%)   24/132 (18.2%)
+  AST &gt;10 - &lt;= 20xULN                                       25/134 (18.7%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   29/132 (22.0%)   23/132 (17.4%)
+  AST &gt; 20xULN                                              26/134 (19.4%)   25/134 (18.7%)   23/134 (17.2%)   30/134 (22.4%)   23/132 (17.4%)   24/132 (18.2%)
+Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN                                                                                                      
+  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   21/134 (15.7%)   30/134 (22.4%)   17/134 (12.7%)   28/132 (21.2%)   31/132 (23.5%)
+  ALT &gt;5 - &lt;= 10xULN                                        36/134 (26.9%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   26/132 (19.7%)   29/132 (22.0%)
+  ALT &gt;10 - &lt;= 20xULN                                       30/134 (22.4%)   21/134 (15.7%)   28/134 (20.9%)   36/134 (26.9%)   25/132 (18.9%)   24/132 (18.2%)
+  ALT &gt; 20xULN                                              14/134 (10.4%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   31/132 (23.5%)   23/132 (17.4%)
+  AST &gt;3 - &lt;= 5xULN                                         21/134 (15.7%)   26/134 (19.4%)   29/134 (21.6%)   31/134 (23.1%)   33/132 (25.0%)   19/132 (14.4%)
+  AST &gt;5 - &lt;= 10xULN                                        29/134 (21.6%)   26/134 (19.4%)   24/134 (17.9%)   26/134 (19.4%)   23/132 (17.4%)   32/132 (24.2%)
+  AST &gt;10 - &lt;= 20xULN                                       29/134 (21.6%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   22/132 (16.7%)   21/132 (15.9%)
+  AST &gt; 20xULN                                              34/134 (25.4%)   21/134 (15.7%)   19/134 (14.2%)   28/134 (20.9%)   21/132 (15.9%)   33/132 (25.0%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt09_cache/html/variant2_ab240562bc75ccef774d4c68d4ff2f0d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"TBILI_CAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="co"># below split helps us get the right denominator between ALT/AST but it can be hidden</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ALTAST_ind"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">vars =</span> <span class="st">"ALTAST_CAT"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">.stats =</span> <span class="st">"fraction"</span>,</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>  <span class="fu">append_topleft</span>(<span class="st">"Liver Laboratory Test Criterion"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adhy_liver)</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a><span class="co"># trim away rows with criteria not met</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-18"><a href="#cb4-18"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb4-20"><a href="#cb4-20"></a>}</span>
+<span id="cb4-21"><a href="#cb4-21"></a></span>
+<span id="cb4-22"><a href="#cb4-22"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-23"><a href="#cb4-23"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Liver Laboratory Test Criterion                                        A: Drug X                        B: Placebo                      C: Combination         
+                                                               BASELINE      POST-BASELINE       BASELINE      POST-BASELINE       BASELINE      POST-BASELINE 
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                                                                                                       
+  ALT &gt;3 - &lt;= 5xULN                                         23/134 (17.2%)   15/134 (11.2%)   25/134 (18.7%)   27/134 (20.1%)   27/132 (20.5%)   30/132 (22.7%)
+  ALT &gt;5 - &lt;= 10xULN                                        28/134 (20.9%)   29/134 (21.6%)   29/134 (21.6%)   19/134 (14.2%)   36/132 (27.3%)   29/132 (22.0%)
+  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   30/134 (22.4%)   32/134 (23.9%)   33/134 (24.6%)   28/132 (21.2%)   24/132 (18.2%)
+  ALT &gt; 20xULN                                              32/134 (23.9%)   35/134 (26.1%)   24/134 (17.9%)   23/134 (17.2%)   20/132 (15.2%)   26/132 (19.7%)
+  AST &gt;3 - &lt;= 5xULN                                         31/134 (23.1%)   34/134 (25.4%)   30/134 (22.4%)   26/134 (19.4%)   34/132 (25.8%)   24/132 (18.2%)
+  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   25/134 (18.7%)   26/134 (19.4%)   26/134 (19.4%)   22/132 (16.7%)   27/132 (20.5%)
+  AST &gt;10 - &lt;= 20xULN                                       22/134 (16.4%)   29/134 (21.6%)   16/134 (11.9%)   22/134 (16.4%)   34/132 (25.8%)   19/132 (14.4%)
+  AST &gt; 20xULN                                              20/134 (14.9%)   16/134 (11.9%)   28/134 (20.9%)   31/134 (23.1%)   21/132 (15.9%)   39/132 (29.5%)
+Total Bilirubin &gt; 2xULN                                                                                                                                        
+  ALT &gt;3 - &lt;= 5xULN                                         40/134 (29.9%)   28/134 (20.9%)   31/134 (23.1%)   28/134 (20.9%)   18/132 (13.6%)   32/132 (24.2%)
+  ALT &gt;5 - &lt;= 10xULN                                        24/134 (17.9%)   29/134 (21.6%)   30/134 (22.4%)   37/134 (27.6%)   33/132 (25.0%)   24/132 (18.2%)
+  ALT &gt;10 - &lt;= 20xULN                                       24/134 (17.9%)   22/134 (16.4%)   26/134 (19.4%)   18/134 (13.4%)   21/132 (15.9%)   30/132 (22.7%)
+  ALT &gt; 20xULN                                              19/134 (14.2%)   33/134 (24.6%)   23/134 (17.2%)   19/134 (14.2%)   30/132 (22.7%)   22/132 (16.7%)
+  AST &gt;3 - &lt;= 5xULN                                         17/134 (12.7%)   27/134 (20.1%)   36/134 (26.9%)   25/134 (18.7%)   26/132 (19.7%)   34/132 (25.8%)
+  AST &gt;5 - &lt;= 10xULN                                        25/134 (18.7%)   28/134 (20.9%)   24/134 (17.9%)   28/134 (20.9%)   20/132 (15.2%)   23/132 (17.4%)
+  AST &gt;10 - &lt;= 20xULN                                       36/134 (26.9%)   28/134 (20.9%)   16/134 (11.9%)   26/134 (19.4%)   33/132 (25.0%)   26/132 (19.7%)
+  AST &gt; 20xULN                                              30/134 (22.4%)   21/134 (15.7%)   30/134 (22.4%)   24/134 (17.9%)   24/132 (18.2%)   25/132 (18.9%)
+Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN                                                                                                      
+  ALT &gt;3 - &lt;= 5xULN                                         24/134 (17.9%)   21/134 (15.7%)   30/134 (22.4%)   17/134 (12.7%)   28/132 (21.2%)   31/132 (23.5%)
+  ALT &gt;5 - &lt;= 10xULN                                        36/134 (26.9%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   26/132 (19.7%)   29/132 (22.0%)
+  ALT &gt;10 - &lt;= 20xULN                                       30/134 (22.4%)   21/134 (15.7%)   28/134 (20.9%)   36/134 (26.9%)   25/132 (18.9%)   24/132 (18.2%)
+  ALT &gt; 20xULN                                              14/134 (10.4%)   28/134 (20.9%)   25/134 (18.7%)   27/134 (20.1%)   31/132 (23.5%)   23/132 (17.4%)
+  AST &gt;3 - &lt;= 5xULN                                         21/134 (15.7%)   26/134 (19.4%)   29/134 (21.6%)   31/134 (23.1%)   33/132 (25.0%)   19/132 (14.4%)
+  AST &gt;5 - &lt;= 10xULN                                        29/134 (21.6%)   26/134 (19.4%)   24/134 (17.9%)   26/134 (19.4%)   23/132 (17.4%)   32/132 (24.2%)
+  AST &gt;10 - &lt;= 20xULN                                       29/134 (21.6%)   31/134 (23.1%)   28/134 (20.9%)   22/134 (16.4%)   22/132 (16.7%)   21/132 (15.9%)
+  AST &gt; 20xULN                                              34/134 (25.4%)   21/134 (15.7%)   19/134 (14.2%)   28/134 (20.9%)   21/132 (15.9%)   33/132 (25.0%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt09_cache/html/teal_5a65a6d3e89a6a36aa5c6988f26b2051">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt09_cache/html/sessioninfo_e1690a2fe6e795f442b97fe83372cb2e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt09_cache/html/snapshot_aadb08404b7c23479f253b7431130a6d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt09.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt08.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT08</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt10.html" class="pagination-link">
+        <span class="nav-page-text">LBT10</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT09</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a></span>
+<span id="cb10-22"><a href="#cb10-22"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adhy_liver <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy)</span>
+<span id="cb10-24"><a href="#cb10-24"></a></span>
+<span id="cb10-25"><a href="#cb10-25"></a><span class="co"># Define values of interest in PARAMCD variable.</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>paramcd_tbili_alt <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"BLAL"</span>, <span class="st">"BGAL"</span>, <span class="st">"BA2AL"</span>, <span class="st">"BA5AL"</span>)</span>
+<span id="cb10-27"><a href="#cb10-27"></a>paramcd_tbili_ast <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"BLAS"</span>, <span class="st">"BGAS"</span>, <span class="st">"BA2AS"</span>, <span class="st">"BA5AS"</span>)</span>
+<span id="cb10-28"><a href="#cb10-28"></a></span>
+<span id="cb10-29"><a href="#cb10-29"></a><span class="co"># Select LBT09 parameters.</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"POST-BASELINE"</span>),</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt, paramcd_tbili_ast)</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  )</span>
+<span id="cb10-36"><a href="#cb10-36"></a></span>
+<span id="cb10-37"><a href="#cb10-37"></a><span class="co"># Let's be explicit about factor levels for AVISIT and PARAMCD.</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">AVISIT =</span> <span class="fu">factor</span>(AVISIT, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"BASELINE"</span>, <span class="st">"POST-BASELINE"</span>)),</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">PARAMCD =</span> <span class="fu">factor</span>(PARAMCD, <span class="at">levels =</span> <span class="fu">c</span>(paramcd_tbili_alt, paramcd_tbili_ast))</span>
+<span id="cb10-42"><a href="#cb10-42"></a>  )</span>
+<span id="cb10-43"><a href="#cb10-43"></a></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="co"># Create indicator and category variables.</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>adhy_liver <span class="ot">&lt;-</span> adhy_liver <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">TBILI_CAT =</span> <span class="fu">factor</span>( <span class="co"># Create TBILI_CAT categories variable - this is needed so we get the right nesting in the table.</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb10-49"><a href="#cb10-49"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">1</span>], paramcd_tbili_ast[<span class="dv">1</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">2</span>], paramcd_tbili_ast[<span class="dv">2</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">3</span>], paramcd_tbili_ast[<span class="dv">3</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb10-52"><a href="#cb10-52"></a>        PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(paramcd_tbili_alt[<span class="dv">4</span>], paramcd_tbili_ast[<span class="dv">4</span>]) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>      ),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-55"><a href="#cb10-55"></a>        <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>        <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb10-57"><a href="#cb10-57"></a>        <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb10-58"><a href="#cb10-58"></a>        <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>      )</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    ),</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">ALTAST_CAT =</span> <span class="fu">factor</span>( <span class="co"># Create ALTAST_CAT categories variable - this will be the labels for different ALT/AST categories displayed in the table.</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb10-63"><a href="#cb10-63"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;3-5ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;5-10ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>,</span>
+<span id="cb10-65"><a href="#cb10-65"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;10-20ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb10-66"><a href="#cb10-66"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;20ULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt; 20xULN"</span>,</span>
+<span id="cb10-67"><a href="#cb10-67"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;3-5ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>,</span>
+<span id="cb10-68"><a href="#cb10-68"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;5-10ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>,</span>
+<span id="cb10-69"><a href="#cb10-69"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;10-20ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb10-70"><a href="#cb10-70"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"&gt;20ULN"</span> <span class="sc">~</span> <span class="st">"AST &gt; 20xULN"</span>,</span>
+<span id="cb10-71"><a href="#cb10-71"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>      ),</span>
+<span id="cb10-73"><a href="#cb10-73"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb10-74"><a href="#cb10-74"></a>        <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>, <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>, <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb10-75"><a href="#cb10-75"></a>        <span class="st">"20"</span> <span class="ot">=</span> <span class="st">"ALT &gt; 20xULN"</span>,</span>
+<span id="cb10-76"><a href="#cb10-76"></a>        <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>, <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>, <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>, <span class="st">"AST &gt; 20xULN"</span>,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>        <span class="st">"Criteria not met"</span></span>
+<span id="cb10-78"><a href="#cb10-78"></a>      )</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    ),</span>
+<span id="cb10-80"><a href="#cb10-80"></a>    <span class="at">ALTAST_ind =</span> <span class="fu">factor</span>(</span>
+<span id="cb10-81"><a href="#cb10-81"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb10-82"><a href="#cb10-82"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_alt <span class="sc">~</span> <span class="st">"ALT"</span>,</span>
+<span id="cb10-83"><a href="#cb10-83"></a>        PARAMCD <span class="sc">%in%</span> paramcd_tbili_ast <span class="sc">~</span> <span class="st">"AST"</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a>      ),</span>
+<span id="cb10-85"><a href="#cb10-85"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"ALT"</span>, <span class="st">"AST"</span>)</span>
+<span id="cb10-86"><a href="#cb10-86"></a>    )</span>
+<span id="cb10-87"><a href="#cb10-87"></a>  )</span>
+<span id="cb10-88"><a href="#cb10-88"></a></span>
+<span id="cb10-89"><a href="#cb10-89"></a>map <span class="ot">&lt;-</span> <span class="fu">data.frame</span>(</span>
+<span id="cb10-90"><a href="#cb10-90"></a>  <span class="at">ALTAST_ind =</span> <span class="fu">c</span>(<span class="fu">rep</span>(<span class="st">"ALT"</span>, <span class="dv">5</span>), <span class="fu">rep</span>(<span class="st">"AST"</span>, <span class="dv">5</span>)),</span>
+<span id="cb10-91"><a href="#cb10-91"></a>  <span class="at">ALTAST_CAT =</span> <span class="fu">c</span>(</span>
+<span id="cb10-92"><a href="#cb10-92"></a>    <span class="st">"ALT &gt;3 - &lt;= 5xULN"</span>, <span class="st">"ALT &gt;5 - &lt;= 10xULN"</span>, <span class="st">"ALT &gt;10 - &lt;= 20xULN"</span>,</span>
+<span id="cb10-93"><a href="#cb10-93"></a>    <span class="st">"20"</span> <span class="ot">=</span> <span class="st">"ALT &gt; 20xULN"</span>, <span class="st">"Criteria not met"</span>,</span>
+<span id="cb10-94"><a href="#cb10-94"></a>    <span class="st">"AST &gt;3 - &lt;= 5xULN"</span>, <span class="st">"AST &gt;5 - &lt;= 10xULN"</span>, <span class="st">"AST &gt;10 - &lt;= 20xULN"</span>, <span class="st">"AST &gt; 20xULN"</span>, <span class="st">"Criteria not met"</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a>  ),</span>
+<span id="cb10-96"><a href="#cb10-96"></a>  <span class="at">stringsAsFactors =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a>)</span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="in">```</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a></span>
+<span id="cb10-102"><a href="#cb10-102"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-103"><a href="#cb10-103"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a>  <span class="fu">split_rows_by</span>(<span class="st">"TBILI_CAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-107"><a href="#cb10-107"></a>  <span class="co"># below split helps us get the right denominator between ALT/AST but it can be hidden</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ALTAST_ind"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="at">vars =</span> <span class="st">"ALTAST_CAT"</span>,</span>
+<span id="cb10-111"><a href="#cb10-111"></a>    <span class="at">.stats =</span> <span class="st">"fraction"</span>,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-113"><a href="#cb10-113"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-114"><a href="#cb10-114"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>  <span class="fu">append_topleft</span>(<span class="st">"Liver Laboratory Test Criterion"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-116"><a href="#cb10-116"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adhy_liver)</span>
+<span id="cb10-117"><a href="#cb10-117"></a></span>
+<span id="cb10-118"><a href="#cb10-118"></a><span class="co"># trim away rows with criteria not met</span></span>
+<span id="cb10-119"><a href="#cb10-119"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-120"><a href="#cb10-120"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-121"><a href="#cb10-121"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-122"><a href="#cb10-122"></a>}</span>
+<span id="cb10-123"><a href="#cb10-123"></a></span>
+<span id="cb10-124"><a href="#cb10-124"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-125"><a href="#cb10-125"></a>result</span>
+<span id="cb10-126"><a href="#cb10-126"></a><span class="in">```</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a></span>
+<span id="cb10-128"><a href="#cb10-128"></a><span class="fu">## Table Selecting Sections</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a></span>
+<span id="cb10-130"><a href="#cb10-130"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb10-131"><a href="#cb10-131"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-132"><a href="#cb10-132"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a>  <span class="fu">split_cols_by</span>(<span class="st">"AVISIT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-134"><a href="#cb10-134"></a>  <span class="fu">split_rows_by</span>(<span class="st">"TBILI_CAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-135"><a href="#cb10-135"></a>  <span class="co"># below split helps us get the right denominator between ALT/AST but it can be hidden</span></span>
+<span id="cb10-136"><a href="#cb10-136"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ALTAST_ind"</span>, <span class="at">split_fun =</span> <span class="fu">trim_levels_to_map</span>(map), <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-137"><a href="#cb10-137"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-138"><a href="#cb10-138"></a>    <span class="at">vars =</span> <span class="st">"ALTAST_CAT"</span>,</span>
+<span id="cb10-139"><a href="#cb10-139"></a>    <span class="at">.stats =</span> <span class="st">"fraction"</span>,</span>
+<span id="cb10-140"><a href="#cb10-140"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-141"><a href="#cb10-141"></a>    <span class="at">drop =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-142"><a href="#cb10-142"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-143"><a href="#cb10-143"></a>  <span class="fu">append_topleft</span>(<span class="st">"Liver Laboratory Test Criterion"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-144"><a href="#cb10-144"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adhy_liver)</span>
+<span id="cb10-145"><a href="#cb10-145"></a></span>
+<span id="cb10-146"><a href="#cb10-146"></a><span class="co"># trim away rows with criteria not met</span></span>
+<span id="cb10-147"><a href="#cb10-147"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-148"><a href="#cb10-148"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-149"><a href="#cb10-149"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-150"><a href="#cb10-150"></a>}</span>
+<span id="cb10-151"><a href="#cb10-151"></a></span>
+<span id="cb10-152"><a href="#cb10-152"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-153"><a href="#cb10-153"></a>result</span>
+<span id="cb10-154"><a href="#cb10-154"></a><span class="in">```</span></span>
+<span id="cb10-155"><a href="#cb10-155"></a></span>
+<span id="cb10-156"><a href="#cb10-156"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-157"><a href="#cb10-157"></a></span>
+<span id="cb10-158"><a href="#cb10-158"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-159"><a href="#cb10-159"></a></span>
+<span id="cb10-160"><a href="#cb10-160"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-161"><a href="#cb10-161"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-162"><a href="#cb10-162"></a></span>
+<span id="cb10-163"><a href="#cb10-163"></a><span class="co"># In progress</span></span>
+<span id="cb10-164"><a href="#cb10-164"></a><span class="in">```</span></span>
+<span id="cb10-165"><a href="#cb10-165"></a></span>
+<span id="cb10-166"><a href="#cb10-166"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-167"><a href="#cb10-167"></a></span>
+<span id="cb10-168"><a href="#cb10-168"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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new file mode 100644
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
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+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT10</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to ULN)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting Sections</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt10_cache/html/setup_9c88924638fd9677c63e6d3f69280c97">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adhy_liver <span class="ot">&lt;-</span> adhy <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="st">"BL2AL2CU"</span>, <span class="st">"BL2AS2CU"</span>, <span class="st">"BG2AL2CU"</span>, <span class="st">"BG2AS2CU"</span>, <span class="st">"B2A2L2CU"</span>, <span class="st">"B2A2S2CU"</span>, <span class="st">"B2A5L2CU"</span>, <span class="st">"B2A5S2CU"</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(<span class="at">PARAMCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CU"</span>, <span class="st">"BL2AS2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BG2AL2CU"</span>, <span class="st">"BG2AS2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A2L2CU"</span>, <span class="st">"B2A2S2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A5L2CU"</span>, <span class="st">"B2A5S2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(<span class="at">AVALC_FORMAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CU"</span>, <span class="st">"BG2AL2CU"</span>, <span class="st">"B2A2L2CU"</span>, <span class="st">"B2A5L2CU"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AS2CU"</span>, <span class="st">"BG2AS2CU"</span>, <span class="st">"B2A2S2CU"</span>, <span class="st">"B2A5S2CU"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"AST &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ))</span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy_liver)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt10_cache/html/variant1_2f2fbd08da879af979f383292a5a2a68">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>tbl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>}</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>result <span class="ot">&lt;-</span> tbl <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                               ARM A            ARM B            ARM C     
+                              (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                   
+  ALT &gt;3xULN at 2 Visits   20/134 (14.9%)   21/134 (15.7%)   20/132 (15.2%)
+  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   25/134 (18.7%)   27/132 (20.5%)
+Total Bilirubin &gt; 2xULN                                                    
+  ALT &gt;3xULN at 2 Visits   24/134 (17.9%)   32/134 (23.9%)   24/132 (18.2%)
+  AST &gt;3xULN at 2 Visits   33/134 (24.6%)   29/134 (21.6%)   25/132 (18.9%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt10_cache/html/variant2_446885d954b33067b74d086cb71d9363">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-14"><a href="#cb4-14"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb4-16"><a href="#cb4-16"></a>}</span>
+<span id="cb4-17"><a href="#cb4-17"></a></span>
+<span id="cb4-18"><a href="#cb4-18"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                               ARM A            ARM B            ARM C     
+                              (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                   
+  ALT &gt;3xULN at 2 Visits   20/134 (14.9%)   21/134 (15.7%)   20/132 (15.2%)
+  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   25/134 (18.7%)   27/132 (20.5%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt10_cache/html/teal_50f644f2bcbdce9078b386dee333dffc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt10_cache/html/sessioninfo_d58a9d361e1472f3101305b7d11fad43">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt10_cache/html/snapshot_8788dbb5978670bcd1eb6a048ffd7852">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt10.lock">Download</a></p>
+</section>
+</div>
+</div>
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+    if (parentEl) {
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+      }
+    } else {
+      return undefined;
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
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+          citeDiv.classList.add('csl-entry');
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+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt09.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT09</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt10_bl.html" class="pagination-link">
+        <span class="nav-page-text">LBT10_BL</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT10</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to ULN)</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adhy_liver <span class="ot">&lt;-</span> adhy <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="st">"BL2AL2CU"</span>, <span class="st">"BL2AS2CU"</span>, <span class="st">"BG2AL2CU"</span>, <span class="st">"BG2AS2CU"</span>, <span class="st">"B2A2L2CU"</span>, <span class="st">"B2A2S2CU"</span>, <span class="st">"B2A5L2CU"</span>, <span class="st">"B2A5S2CU"</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>  <span class="fu">mutate</span>(<span class="at">PARAMCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CU"</span>, <span class="st">"BL2AS2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BG2AL2CU"</span>, <span class="st">"BG2AS2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A2L2CU"</span>, <span class="st">"B2A2S2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A5L2CU"</span>, <span class="st">"B2A5S2CU"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">mutate</span>(<span class="at">AVALC_FORMAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CU"</span>, <span class="st">"BG2AL2CU"</span>, <span class="st">"B2A2L2CU"</span>, <span class="st">"B2A5L2CU"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AS2CU"</span>, <span class="st">"BG2AS2CU"</span>, <span class="st">"B2A2S2CU"</span>, <span class="st">"B2A5S2CU"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"AST &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>  ))</span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-41"><a href="#cb10-41"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy_liver)</span>
+<span id="cb10-42"><a href="#cb10-42"></a><span class="in">```</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a></span>
+<span id="cb10-46"><a href="#cb10-46"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>tbl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-58"><a href="#cb10-58"></a></span>
+<span id="cb10-59"><a href="#cb10-59"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-60"><a href="#cb10-60"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-61"><a href="#cb10-61"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-62"><a href="#cb10-62"></a>}</span>
+<span id="cb10-63"><a href="#cb10-63"></a></span>
+<span id="cb10-64"><a href="#cb10-64"></a>result <span class="ot">&lt;-</span> tbl <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-65"><a href="#cb10-65"></a>result</span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="in">```</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="fu">## Table Selecting Sections</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a></span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-76"><a href="#cb10-76"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-85"><a href="#cb10-85"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-86"><a href="#cb10-86"></a>}</span>
+<span id="cb10-87"><a href="#cb10-87"></a></span>
+<span id="cb10-88"><a href="#cb10-88"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-89"><a href="#cb10-89"></a>result</span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="in">```</span></span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-93"><a href="#cb10-93"></a></span>
+<span id="cb10-94"><a href="#cb10-94"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a></span>
+<span id="cb10-96"><a href="#cb10-96"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a></span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="co"># In progress</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="in">```</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a></span>
+<span id="cb10-102"><a href="#cb10-102"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-103"><a href="#cb10-103"></a></span>
+<span id="cb10-104"><a href="#cb10-104"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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new file mode 100644
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@@ -0,0 +1,2145 @@
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+.sourceCode { overflow: visible; }
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+div.sourceCode { overflow: auto; }
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+pre.numberSource code > span > a:first-child::before
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+div.sourceCode
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+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT10_BL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to Baseline)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting Sections</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt10_bl_cache/html/setup_5f4c73ac0ec9a38f1a80b6ebc38eeb24">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adhy_liver <span class="ot">&lt;-</span> adhy <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb1-10"><a href="#cb1-10"></a>    <span class="st">"BL2AL2CB"</span>, <span class="st">"BL2AS2CB"</span>, <span class="st">"BG2AL2CB"</span>, <span class="st">"BG2AS2CB"</span>, <span class="st">"B2A2L2CB"</span>, <span class="st">"B2A2S2CB"</span>, <span class="st">"B2A5L2CB"</span>, <span class="st">"B2A5S2CB"</span></span>
+<span id="cb1-11"><a href="#cb1-11"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(<span class="at">PARAMCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CB"</span>, <span class="st">"BL2AS2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BG2AL2CB"</span>, <span class="st">"BG2AS2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A2L2CB"</span>, <span class="st">"B2A2S2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A5L2CB"</span>, <span class="st">"B2A5S2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">mutate</span>(<span class="at">AVALC_FORMAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CB"</span>, <span class="st">"BG2AL2CB"</span>, <span class="st">"B2A2L2CB"</span>, <span class="st">"B2A5L2CB"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AS2CB"</span>, <span class="st">"BG2AS2CB"</span>, <span class="st">"B2A2S2CB"</span>, <span class="st">"B2A5S2CB"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"AST &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ))</span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-26"><a href="#cb1-26"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy_liver)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt10_bl_cache/html/variant1_66e3bb55395681735d4a89d80753ecd6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>tbl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a>}</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>result <span class="ot">&lt;-</span> tbl <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                               ARM A            ARM B            ARM C     
+                              (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                   
+  ALT &gt;3xULN at 2 Visits   25/134 (18.7%)   20/134 (14.9%)   27/132 (20.5%)
+  AST &gt;3xULN at 2 Visits   22/134 (16.4%)   14/134 (10.4%)   37/132 (28.0%)
+Total Bilirubin &gt; 2xULN                                                    
+  ALT &gt;3xULN at 2 Visits   26/134 (19.4%)   31/134 (23.1%)   23/132 (17.4%)
+  AST &gt;3xULN at 2 Visits   30/134 (22.4%)   27/134 (20.1%)   26/132 (19.7%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt10_bl_cache/html/variant2_946906eff890628718d2c2f77c73ad1f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb4-14"><a href="#cb4-14"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb4-16"><a href="#cb4-16"></a>}</span>
+<span id="cb4-17"><a href="#cb4-17"></a></span>
+<span id="cb4-18"><a href="#cb4-18"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb4-19"><a href="#cb4-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                               ARM A            ARM B            ARM C     
+                              (N=134)          (N=134)          (N=132)    
+———————————————————————————————————————————————————————————————————————————
+Total Bilirubin &lt;= 2xULN                                                   
+  ALT &gt;3xULN at 2 Visits   25/134 (18.7%)   20/134 (14.9%)   27/132 (20.5%)
+  AST &gt;3xULN at 2 Visits   22/134 (16.4%)   14/134 (10.4%)   37/132 (28.0%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt10_bl_cache/html/teal_712806482b12a131c14253dde18d91fb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt10_bl_cache/html/sessioninfo_c1f9d802553d31e20c21fdec4e7a3f40">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt10_bl_cache/html/snapshot_e40248b7cbac2405c9609631177fca4a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt10_bl.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
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+              gutter.appendChild(gutterDiv);
+            }
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+            gutterDiv.style.height = height + 4 + "px";
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+          selectedAnnoteEl = annoteEl;
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+      const unselectCodeLines = () => {
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+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+          popup.appendChild(citeDiv);
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+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt10.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT10</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt11.html" class="pagination-link">
+        <span class="nav-page-text">LBT11</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> LBT10_BL</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to Baseline)</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a>adhy_liver <span class="ot">&lt;-</span> adhy <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="fu">filter</span>(PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="st">"BL2AL2CB"</span>, <span class="st">"BL2AS2CB"</span>, <span class="st">"BG2AL2CB"</span>, <span class="st">"BG2AS2CB"</span>, <span class="st">"B2A2L2CB"</span>, <span class="st">"B2A2S2CB"</span>, <span class="st">"B2A5L2CB"</span>, <span class="st">"B2A5S2CB"</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb10-27"><a href="#cb10-27"></a>  <span class="fu">mutate</span>(<span class="at">PARAMCAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-28"><a href="#cb10-28"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CB"</span>, <span class="st">"BL2AS2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &lt;= 2xULN"</span>,</span>
+<span id="cb10-29"><a href="#cb10-29"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BG2AL2CB"</span>, <span class="st">"BG2AS2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN"</span>,</span>
+<span id="cb10-30"><a href="#cb10-30"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A2L2CB"</span>, <span class="st">"B2A2S2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 2xULN"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"B2A5L2CB"</span>, <span class="st">"B2A5S2CB"</span>) <span class="sc">~</span> <span class="st">"Total Bilirubin &gt; 2xULN and Alkaline Phosphatase &lt;= 5xULN"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>  )) <span class="sc">%&gt;%</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a>  <span class="fu">mutate</span>(<span class="at">AVALC_FORMAT =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AL2CB"</span>, <span class="st">"BG2AL2CB"</span>, <span class="st">"B2A2L2CB"</span>, <span class="st">"B2A5L2CB"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"BL2AS2CB"</span>, <span class="st">"BG2AS2CB"</span>, <span class="st">"B2A2S2CB"</span>, <span class="st">"B2A5S2CB"</span>) <span class="sc">&amp;</span> AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="st">"AST &gt;3xULN at 2 Visits"</span>,</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>  ))</span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-41"><a href="#cb10-41"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adhy_liver)</span>
+<span id="cb10-42"><a href="#cb10-42"></a><span class="in">```</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a></span>
+<span id="cb10-46"><a href="#cb10-46"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>tbl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb10-54"><a href="#cb10-54"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-58"><a href="#cb10-58"></a></span>
+<span id="cb10-59"><a href="#cb10-59"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-60"><a href="#cb10-60"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-61"><a href="#cb10-61"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-62"><a href="#cb10-62"></a>}</span>
+<span id="cb10-63"><a href="#cb10-63"></a></span>
+<span id="cb10-64"><a href="#cb10-64"></a>result <span class="ot">&lt;-</span> tbl <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-65"><a href="#cb10-65"></a>result</span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="in">```</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="fu">## Table Selecting Sections</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a></span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>tbl2 <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-72"><a href="#cb10-72"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARMCD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAMCAT"</span>, <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="st">"Total Bilirubin &gt; 2xULN"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb10-76"><a href="#cb10-76"></a>    <span class="at">vars =</span> <span class="st">"AVALC_FORMAT"</span>,</span>
+<span id="cb10-77"><a href="#cb10-77"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"fraction"</span>),</span>
+<span id="cb10-78"><a href="#cb10-78"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb10-79"><a href="#cb10-79"></a>    <span class="at">drop =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-81"><a href="#cb10-81"></a>  <span class="fu">build_table</span>(anl, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb10-84"><a href="#cb10-84"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb10-85"><a href="#cb10-85"></a>  <span class="fu">ifelse</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb10-86"><a href="#cb10-86"></a>}</span>
+<span id="cb10-87"><a href="#cb10-87"></a></span>
+<span id="cb10-88"><a href="#cb10-88"></a>result <span class="ot">&lt;-</span> tbl2 <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb10-89"><a href="#cb10-89"></a>result</span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="in">```</span></span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-93"><a href="#cb10-93"></a></span>
+<span id="cb10-94"><a href="#cb10-94"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a></span>
+<span id="cb10-96"><a href="#cb10-96"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-97"><a href="#cb10-97"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a></span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="co"># In progress</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="in">```</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a></span>
+<span id="cb10-102"><a href="#cb10-102"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-103"><a href="#cb10-103"></a></span>
+<span id="cb10-104"><a href="#cb10-104"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/tables/lab-results/lbt11.html b/stable/tables/lab-results/lbt11.html
new file mode 100644
index 0000000000..33c744e7ec
--- /dev/null
+++ b/stable/tables/lab-results/lbt11.html
@@ -0,0 +1,2411 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT11</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT11</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to ULN)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
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+    
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+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Time-To-Event Summary</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Time-To-Event Summary <br> Selecting Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Time-To-Event Summary <br> with Stratified Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt11_cache/html/setup_9e9e35f1c4d393afae499da47f29505a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl_safl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>anl <span class="ot">&lt;-</span> adsaftte <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    PARAMCD <span class="sc">==</span> <span class="st">"HYSTTEUL"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">AVAL =</span> .data<span class="sc">$</span>AVAL <span class="sc">*</span> dplyr<span class="sc">::</span><span class="fu">case_when</span>( <span class="co"># convert to days, if possible</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"WEEKS"</span> <span class="sc">~</span> <span class="dv">7</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"MONTHS"</span> <span class="sc">~</span> <span class="fl">30.4375</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"YEARS"</span> <span class="sc">~</span> <span class="dv">365</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">1</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AVALU =</span> <span class="fu">factor</span>(dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      .data<span class="sc">$</span>AVALU <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEKS"</span>, <span class="st">"MONTHS"</span>, <span class="st">"YEARS"</span>) <span class="sc">~</span> <span class="fu">factor</span>(<span class="st">"DAYS"</span>),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> .data<span class="sc">$</span>AVALU</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    ), <span class="at">levels =</span> <span class="st">"DAYS"</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>, <span class="co"># this will be a LLT event</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">event_grp =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>        CNSR <span class="sc">==</span> <span class="dv">0</span> <span class="sc">~</span> <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>        CNSR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>      ),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>        <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>      )</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    )</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt11_cache/html/variant1_5c941e8553cec16cf1d670ff8bb1b4dd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  )</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B            ARM C    
+                                    (N=134)         (N=134)          (N=132)   
+———————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   
+Patients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) 
+Time to 1st LLT Event (DAYS)                                                   
+  Median                              NA               NA             728.0    
+    95% CI                            NA          (724.0, NA)          NA      
+  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 
+  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 
+  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0
+Unstratified Analysis                                                          
+  p-value (log-rank)                                 0.0295          0.1687    
+  Hazard Ratio                                        0.43            0.58     
+  95% CI                                          (0.19, 0.94)    (0.26, 1.27) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt11_cache/html/variant2_e2abf1e1a2afdf447e5377e1cd964b62">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  )</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B            ARM C    
+                                    (N=134)         (N=134)          (N=132)   
+———————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   
+Patients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) 
+Time to 1st LLT Event (DAYS)                                                   
+  Median                              NA               NA             728.0    
+    95% CI                            NA          (724.0, NA)          NA      
+  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 
+  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 
+  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="lbt11_cache/html/variant3_ab608884b1c8e1a068d51bf9ef51bcd5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>strata <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Stratified By: "</span>, <span class="fu">paste</span>(strata, <span class="at">collapse =</span> <span class="st">", "</span>)),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">strat =</span> strata,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  )</span>
+<span id="cb6-26"><a href="#cb6-26"></a></span>
+<span id="cb6-27"><a href="#cb6-27"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb6-28"><a href="#cb6-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B            ARM C    
+                                    (N=134)         (N=134)          (N=132)   
+———————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       20 (14.9%)        9 (6.7%)        9 (6.8%)   
+Patients without LLT event (%)    114 (85.1%)     125 (93.3%)      123 (93.2%) 
+Time to 1st LLT Event (DAYS)                                                   
+  Median                              NA               NA             728.0    
+    95% CI                            NA          (724.0, NA)          NA      
+  25% and 75%-ile                  618.0, NA       724.0, NA      728.0, 728.0 
+  Range (censored)               1.0 to 731.0     1.0 to 728.0    1.0 to 722.0 
+  Range (event)                  34.0 to 666.0   139.0 to 724.0   10.0 to 728.0
+Unstratified Analysis                                                          
+  p-value (log-rank)                                 0.0295          0.1687    
+  Hazard Ratio                                        0.43            0.58     
+  95% CI                                          (0.19, 0.94)    (0.26, 1.27) 
+Stratified By: RACE, SEX                                                       
+  p-value (log-rank)                                 0.0858          0.1605    
+  Hazard Ratio                                        0.51            0.57     
+  95% CI                                          (0.23, 1.12)    (0.26, 1.26) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="lbt11_cache/html/teal_dc06c0e1e25ebcc19901a70826d089e9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-5"><a href="#cb8-5"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-9"><a href="#cb8-9"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb8-10"><a href="#cb8-10"></a></span>
+<span id="cb8-11"><a href="#cb8-11"></a>adsl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-12"><a href="#cb8-12"></a>adsaftte <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsaftte, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-13"><a href="#cb8-13"></a></span>
+<span id="cb8-14"><a href="#cb8-14"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb8-18"><a href="#cb8-18"></a>  ),</span>
+<span id="cb8-19"><a href="#cb8-19"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>  )</span>
+<span id="cb8-23"><a href="#cb8-23"></a>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>      adsl,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>    ),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-33"><a href="#cb8-33"></a>      <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>      adsaftte,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb8-36"><a href="#cb8-36"></a>      <span class="at">code =</span> <span class="st">'ADSAFTTE &lt;- synthetic_cdisc_dataset("latest", "adaette") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>    ),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  ),</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>      <span class="at">label =</span> <span class="st">"Time To LLT Event Table"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>      <span class="at">dataname =</span> <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>        <span class="st">"ARM"</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>      ),</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-50"><a href="#cb8-50"></a>        <span class="fu">value_choices</span>(adsaftte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="st">"HYSTTEUL"</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>      ),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb8-55"><a href="#cb8-55"></a>        <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb8-56"><a href="#cb8-56"></a>      ),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="dv">0</span>, <span class="cn">NULL</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(<span class="st">"EVNTDESC"</span>, <span class="st">"EVNTDESC"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    )</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  )</span>
+<span id="cb8-61"><a href="#cb8-61"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:27:24.6782 pid:12139 token:[] teal.modules.clinical Initializing tm_t_tte</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt11_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt11_cache/html/sessioninfo_a8956835873d93c624d05633030f953b">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt11_cache/html/snapshot_ae630c470627e408312e3876922051ae">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt11.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+  const manageTransitions = (selector, allowTransitions) => {
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+        if (sheetNode.id === "quarto-bootstrap") {
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+      disableStylesheet(alternateStylesheets);
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+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
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+      window.scrollTo(0, 1);
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+  // Switch to dark mode if need be
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+  const icon = "";
+  const anchorJS = new window.AnchorJS();
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+    placement: 'right',
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+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
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+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
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+    // clear code selection
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+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
+        }
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+      const fromCls = show ? "hidden" : "unhidden";
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+        if (codeDiv.classList.contains(fromCls)) {
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+  }
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+    tippyHover(ref, function() {
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+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+        <span class="nav-page-text">LBT11_BL</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> LBT11</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Time to First Increase in Liver Laboratory Test Result Meeting Hy's Law Laboratory Critieria (with Respect to ULN)</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a></span>
+<span id="cb14-20"><a href="#cb14-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a></span>
+<span id="cb14-23"><a href="#cb14-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-24"><a href="#cb14-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-25"><a href="#cb14-25"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb14-26"><a href="#cb14-26"></a></span>
+<span id="cb14-27"><a href="#cb14-27"></a>adsl_safl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-28"><a href="#cb14-28"></a></span>
+<span id="cb14-29"><a href="#cb14-29"></a>anl <span class="ot">&lt;-</span> adsaftte <span class="sc">%&gt;%</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb14-31"><a href="#cb14-31"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-32"><a href="#cb14-32"></a>    PARAMCD <span class="sc">==</span> <span class="st">"HYSTTEUL"</span></span>
+<span id="cb14-33"><a href="#cb14-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-34"><a href="#cb14-34"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb14-35"><a href="#cb14-35"></a>    <span class="at">AVAL =</span> .data<span class="sc">$</span>AVAL <span class="sc">*</span> dplyr<span class="sc">::</span><span class="fu">case_when</span>( <span class="co"># convert to days, if possible</span></span>
+<span id="cb14-36"><a href="#cb14-36"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"WEEKS"</span> <span class="sc">~</span> <span class="dv">7</span>,</span>
+<span id="cb14-37"><a href="#cb14-37"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"MONTHS"</span> <span class="sc">~</span> <span class="fl">30.4375</span>,</span>
+<span id="cb14-38"><a href="#cb14-38"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"YEARS"</span> <span class="sc">~</span> <span class="dv">365</span>,</span>
+<span id="cb14-39"><a href="#cb14-39"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">1</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>    ),</span>
+<span id="cb14-41"><a href="#cb14-41"></a>    <span class="at">AVALU =</span> <span class="fu">factor</span>(dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb14-42"><a href="#cb14-42"></a>      .data<span class="sc">$</span>AVALU <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEKS"</span>, <span class="st">"MONTHS"</span>, <span class="st">"YEARS"</span>) <span class="sc">~</span> <span class="fu">factor</span>(<span class="st">"DAYS"</span>),</span>
+<span id="cb14-43"><a href="#cb14-43"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> .data<span class="sc">$</span>AVALU</span>
+<span id="cb14-44"><a href="#cb14-44"></a>    ), <span class="at">levels =</span> <span class="st">"DAYS"</span>),</span>
+<span id="cb14-45"><a href="#cb14-45"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>, <span class="co"># this will be a LLT event</span></span>
+<span id="cb14-46"><a href="#cb14-46"></a>    <span class="at">event_grp =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-47"><a href="#cb14-47"></a>      dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb14-48"><a href="#cb14-48"></a>        CNSR <span class="sc">==</span> <span class="dv">0</span> <span class="sc">~</span> <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb14-49"><a href="#cb14-49"></a>        CNSR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a>      ),</span>
+<span id="cb14-51"><a href="#cb14-51"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-52"><a href="#cb14-52"></a>        <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb14-53"><a href="#cb14-53"></a>        <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb14-54"><a href="#cb14-54"></a>      )</span>
+<span id="cb14-55"><a href="#cb14-55"></a>    )</span>
+<span id="cb14-56"><a href="#cb14-56"></a>  )</span>
+<span id="cb14-57"><a href="#cb14-57"></a><span class="in">```</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a></span>
+<span id="cb14-59"><a href="#cb14-59"></a><span class="fu">## Time-To-Event Summary</span></span>
+<span id="cb14-60"><a href="#cb14-60"></a></span>
+<span id="cb14-61"><a href="#cb14-61"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb14-62"><a href="#cb14-62"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-65"><a href="#cb14-65"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-66"><a href="#cb14-66"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-67"><a href="#cb14-67"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-68"><a href="#cb14-68"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-71"><a href="#cb14-71"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-72"><a href="#cb14-72"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-73"><a href="#cb14-73"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb14-76"><a href="#cb14-76"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>  )</span>
+<span id="cb14-78"><a href="#cb14-78"></a></span>
+<span id="cb14-79"><a href="#cb14-79"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-80"><a href="#cb14-80"></a>result</span>
+<span id="cb14-81"><a href="#cb14-81"></a><span class="in">```</span></span>
+<span id="cb14-82"><a href="#cb14-82"></a></span>
+<span id="cb14-83"><a href="#cb14-83"></a><span class="fu">## Time-To-Event Summary &lt;br/&gt; Selecting Sections to Display</span></span>
+<span id="cb14-84"><a href="#cb14-84"></a></span>
+<span id="cb14-85"><a href="#cb14-85"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb14-86"><a href="#cb14-86"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-87"><a href="#cb14-87"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-88"><a href="#cb14-88"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-90"><a href="#cb14-90"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-91"><a href="#cb14-91"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-92"><a href="#cb14-92"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-93"><a href="#cb14-93"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-94"><a href="#cb14-94"></a>  )</span>
+<span id="cb14-95"><a href="#cb14-95"></a></span>
+<span id="cb14-96"><a href="#cb14-96"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-97"><a href="#cb14-97"></a>result</span>
+<span id="cb14-98"><a href="#cb14-98"></a><span class="in">```</span></span>
+<span id="cb14-99"><a href="#cb14-99"></a></span>
+<span id="cb14-100"><a href="#cb14-100"></a><span class="fu">## Time-To-Event Summary &lt;br/&gt; with Stratified Analysis</span></span>
+<span id="cb14-101"><a href="#cb14-101"></a></span>
+<span id="cb14-102"><a href="#cb14-102"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb14-103"><a href="#cb14-103"></a>strata <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb14-104"><a href="#cb14-104"></a></span>
+<span id="cb14-105"><a href="#cb14-105"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-107"><a href="#cb14-107"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-108"><a href="#cb14-108"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-110"><a href="#cb14-110"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-111"><a href="#cb14-111"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-112"><a href="#cb14-112"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-113"><a href="#cb14-113"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-114"><a href="#cb14-114"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-115"><a href="#cb14-115"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-116"><a href="#cb14-116"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-117"><a href="#cb14-117"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb14-118"><a href="#cb14-118"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb14-119"><a href="#cb14-119"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb14-120"><a href="#cb14-120"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-121"><a href="#cb14-121"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-122"><a href="#cb14-122"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-123"><a href="#cb14-123"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-124"><a href="#cb14-124"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Stratified By: "</span>, <span class="fu">paste</span>(strata, <span class="at">collapse =</span> <span class="st">", "</span>)),</span>
+<span id="cb14-125"><a href="#cb14-125"></a>    <span class="at">strat =</span> strata,</span>
+<span id="cb14-126"><a href="#cb14-126"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb14-127"><a href="#cb14-127"></a>  )</span>
+<span id="cb14-128"><a href="#cb14-128"></a></span>
+<span id="cb14-129"><a href="#cb14-129"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-130"><a href="#cb14-130"></a>result</span>
+<span id="cb14-131"><a href="#cb14-131"></a><span class="in">```</span></span>
+<span id="cb14-132"><a href="#cb14-132"></a></span>
+<span id="cb14-133"><a href="#cb14-133"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-134"><a href="#cb14-134"></a></span>
+<span id="cb14-135"><a href="#cb14-135"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-136"><a href="#cb14-136"></a></span>
+<span id="cb14-137"><a href="#cb14-137"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-138"><a href="#cb14-138"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb14-139"><a href="#cb14-139"></a></span>
+<span id="cb14-140"><a href="#cb14-140"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-141"><a href="#cb14-141"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-142"><a href="#cb14-142"></a></span>
+<span id="cb14-143"><a href="#cb14-143"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-144"><a href="#cb14-144"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb14-145"><a href="#cb14-145"></a></span>
+<span id="cb14-146"><a href="#cb14-146"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-147"><a href="#cb14-147"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-148"><a href="#cb14-148"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb14-149"><a href="#cb14-149"></a></span>
+<span id="cb14-150"><a href="#cb14-150"></a>adsl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-151"><a href="#cb14-151"></a>adsaftte <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsaftte, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-152"><a href="#cb14-152"></a></span>
+<span id="cb14-153"><a href="#cb14-153"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb14-154"><a href="#cb14-154"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb14-155"><a href="#cb14-155"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb14-156"><a href="#cb14-156"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb14-157"><a href="#cb14-157"></a>  ),</span>
+<span id="cb14-158"><a href="#cb14-158"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb14-159"><a href="#cb14-159"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb14-160"><a href="#cb14-160"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb14-161"><a href="#cb14-161"></a>  )</span>
+<span id="cb14-162"><a href="#cb14-162"></a>)</span>
+<span id="cb14-163"><a href="#cb14-163"></a></span>
+<span id="cb14-164"><a href="#cb14-164"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-165"><a href="#cb14-165"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-166"><a href="#cb14-166"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-167"><a href="#cb14-167"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb14-168"><a href="#cb14-168"></a>      adsl,</span>
+<span id="cb14-169"><a href="#cb14-169"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb14-170"><a href="#cb14-170"></a>    ),</span>
+<span id="cb14-171"><a href="#cb14-171"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-172"><a href="#cb14-172"></a>      <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb14-173"><a href="#cb14-173"></a>      adsaftte,</span>
+<span id="cb14-174"><a href="#cb14-174"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb14-175"><a href="#cb14-175"></a>      <span class="at">code =</span> <span class="st">'ADSAFTTE &lt;- synthetic_cdisc_dataset("latest", "adaette") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb14-176"><a href="#cb14-176"></a>    ),</span>
+<span id="cb14-177"><a href="#cb14-177"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-178"><a href="#cb14-178"></a>  ),</span>
+<span id="cb14-179"><a href="#cb14-179"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-180"><a href="#cb14-180"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb14-181"><a href="#cb14-181"></a>      <span class="at">label =</span> <span class="st">"Time To LLT Event Table"</span>,</span>
+<span id="cb14-182"><a href="#cb14-182"></a>      <span class="at">dataname =</span> <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb14-183"><a href="#cb14-183"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-184"><a href="#cb14-184"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb14-185"><a href="#cb14-185"></a>        <span class="st">"ARM"</span></span>
+<span id="cb14-186"><a href="#cb14-186"></a>      ),</span>
+<span id="cb14-187"><a href="#cb14-187"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb14-188"><a href="#cb14-188"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-189"><a href="#cb14-189"></a>        <span class="fu">value_choices</span>(adsaftte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb14-190"><a href="#cb14-190"></a>        <span class="st">"HYSTTEUL"</span></span>
+<span id="cb14-191"><a href="#cb14-191"></a>      ),</span>
+<span id="cb14-192"><a href="#cb14-192"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-193"><a href="#cb14-193"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb14-194"><a href="#cb14-194"></a>        <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb14-195"><a href="#cb14-195"></a>      ),</span>
+<span id="cb14-196"><a href="#cb14-196"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="dv">0</span>, <span class="cn">NULL</span>),</span>
+<span id="cb14-197"><a href="#cb14-197"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(<span class="st">"EVNTDESC"</span>, <span class="st">"EVNTDESC"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-198"><a href="#cb14-198"></a>    )</span>
+<span id="cb14-199"><a href="#cb14-199"></a>  )</span>
+<span id="cb14-200"><a href="#cb14-200"></a>)</span>
+<span id="cb14-201"><a href="#cb14-201"></a></span>
+<span id="cb14-202"><a href="#cb14-202"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-203"><a href="#cb14-203"></a><span class="in">```</span></span>
+<span id="cb14-204"><a href="#cb14-204"></a></span>
+<span id="cb14-205"><a href="#cb14-205"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-206"><a href="#cb14-206"></a></span>
+<span id="cb14-207"><a href="#cb14-207"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
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diff --git a/stable/tables/lab-results/lbt11_bl.html b/stable/tables/lab-results/lbt11_bl.html
new file mode 100644
index 0000000000..d887e1e750
--- /dev/null
+++ b/stable/tables/lab-results/lbt11_bl.html
@@ -0,0 +1,2411 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT11_BL</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/lab-results/lbt12.html" rel="next">
+<link href="../../tables/lab-results/lbt11.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
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+<script src="../../site_libs/quarto-html/quarto.js"></script>
+<script src="../../site_libs/quarto-html/popper.min.js"></script>
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+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT11_BL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to Baseline)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Time-To-Event Summary</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Time-To-Event Summary <br> Selecting Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Time-To-Event Summary <br> with Stratified Analysis</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt11_bl_cache/html/setup_d1a97e5ac493bbc92395fcb2307922d1">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl_safl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a></span>
+<span id="cb1-14"><a href="#cb1-14"></a>anl <span class="ot">&lt;-</span> adsaftte <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    PARAMCD <span class="sc">==</span> <span class="st">"HYSTTEBL"</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">AVAL =</span> .data<span class="sc">$</span>AVAL <span class="sc">*</span> dplyr<span class="sc">::</span><span class="fu">case_when</span>( <span class="co"># convert to days, if possible</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"WEEKS"</span> <span class="sc">~</span> <span class="dv">7</span>,</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"MONTHS"</span> <span class="sc">~</span> <span class="fl">30.4375</span>,</span>
+<span id="cb1-23"><a href="#cb1-23"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"YEARS"</span> <span class="sc">~</span> <span class="dv">365</span>,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">1</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>    ),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">AVALU =</span> <span class="fu">factor</span>(dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      .data<span class="sc">$</span>AVALU <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEKS"</span>, <span class="st">"MONTHS"</span>, <span class="st">"YEARS"</span>) <span class="sc">~</span> <span class="fu">factor</span>(<span class="st">"DAYS"</span>),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> .data<span class="sc">$</span>AVALU</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    ), <span class="at">levels =</span> <span class="st">"DAYS"</span>),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>, <span class="co"># this will be a LLT event</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">event_grp =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-32"><a href="#cb1-32"></a>      dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>        CNSR <span class="sc">==</span> <span class="dv">0</span> <span class="sc">~</span> <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>        CNSR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>      ),</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb1-37"><a href="#cb1-37"></a>        <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>        <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>      )</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    )</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt11_bl_cache/html/variant1_c903fc1aeffd6be3863e8a128784fbd8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  )</span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb2-19"><a href="#cb2-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B           ARM C    
+                                    (N=134)         (N=134)         (N=132)   
+——————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  
+Patients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) 
+Time to 1st LLT Event (DAYS)                                                  
+  Median                              NA              NA             721.0    
+    95% CI                            NA          (681.0, NA)     (691.0, NA) 
+  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  
+  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 
+  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0
+Unstratified Analysis                                                         
+  p-value (log-rank)                                0.5013          0.6413    
+  Hazard Ratio                                       1.27            0.84     
+  95% CI                                         (0.63, 2.56)    (0.40, 1.75) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt11_bl_cache/html/variant2_3c6203ff6fcc6a4ce27bfddaae48a99a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  )</span>
+<span id="cb4-10"><a href="#cb4-10"></a></span>
+<span id="cb4-11"><a href="#cb4-11"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb4-12"><a href="#cb4-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B           ARM C    
+                                    (N=134)         (N=134)         (N=132)   
+——————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  
+Patients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) 
+Time to 1st LLT Event (DAYS)                                                  
+  Median                              NA              NA             721.0    
+    95% CI                            NA          (681.0, NA)     (691.0, NA) 
+  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  
+  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 
+  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="lbt11_bl_cache/html/variant3_f312ad33a9fcb6d05e53a3de16e0d365">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>strata <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Stratified By: "</span>, <span class="fu">paste</span>(strata, <span class="at">collapse =</span> <span class="st">", "</span>)),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">strat =</span> strata,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  )</span>
+<span id="cb6-26"><a href="#cb6-26"></a></span>
+<span id="cb6-27"><a href="#cb6-27"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb6-28"><a href="#cb6-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                     ARM A           ARM B           ARM C    
+                                    (N=134)         (N=134)         (N=132)   
+——————————————————————————————————————————————————————————————————————————————
+Patients with LLT event (%)       14 (10.4%)      18 (13.4%)      15 (11.4%)  
+Patients without LLT event (%)    120 (89.6%)     116 (86.6%)     117 (88.6%) 
+Time to 1st LLT Event (DAYS)                                                  
+  Median                              NA              NA             721.0    
+    95% CI                            NA          (681.0, NA)     (691.0, NA) 
+  25% and 75%-ile                  608.0, NA       558.0, NA       644.0, NA  
+  Range (censored)               1.0 to 728.0    1.0 to 726.0    1.0 to 724.0 
+  Range (event)                  23.0 to 608.0   36.0 to 681.0   61.0 to 721.0
+Unstratified Analysis                                                         
+  p-value (log-rank)                                0.5013          0.6413    
+  Hazard Ratio                                       1.27            0.84     
+  95% CI                                         (0.63, 2.56)    (0.40, 1.75) 
+Stratified By: RACE, SEX                                                      
+  p-value (log-rank)                                0.3886          0.7970    
+  Hazard Ratio                                       1.39            0.91     
+  95% CI                                         (0.65, 2.97)    (0.43, 1.93) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:20}" data-hash="lbt11_bl_cache/html/teal_3d9d87c7f3c57b7a09396a64392bb8ab">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-3"><a href="#cb8-3"></a></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb8-5"><a href="#cb8-5"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb8-6"><a href="#cb8-6"></a></span>
+<span id="cb8-7"><a href="#cb8-7"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb8-9"><a href="#cb8-9"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb8-10"><a href="#cb8-10"></a></span>
+<span id="cb8-11"><a href="#cb8-11"></a>adsl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-12"><a href="#cb8-12"></a>adsaftte <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsaftte, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-13"><a href="#cb8-13"></a></span>
+<span id="cb8-14"><a href="#cb8-14"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb8-18"><a href="#cb8-18"></a>  ),</span>
+<span id="cb8-19"><a href="#cb8-19"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>  )</span>
+<span id="cb8-23"><a href="#cb8-23"></a>)</span>
+<span id="cb8-24"><a href="#cb8-24"></a></span>
+<span id="cb8-25"><a href="#cb8-25"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb8-27"><a href="#cb8-27"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>      adsl,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>    ),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb8-33"><a href="#cb8-33"></a>      <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>      adsaftte,</span>
+<span id="cb8-35"><a href="#cb8-35"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb8-36"><a href="#cb8-36"></a>      <span class="at">code =</span> <span class="st">'ADSAFTTE &lt;- synthetic_cdisc_dataset("latest", "adaette") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb8-37"><a href="#cb8-37"></a>    ),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb8-39"><a href="#cb8-39"></a>  ),</span>
+<span id="cb8-40"><a href="#cb8-40"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>      <span class="at">label =</span> <span class="st">"Time To LLT Event Table"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>      <span class="at">dataname =</span> <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-45"><a href="#cb8-45"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb8-46"><a href="#cb8-46"></a>        <span class="st">"ARM"</span></span>
+<span id="cb8-47"><a href="#cb8-47"></a>      ),</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-50"><a href="#cb8-50"></a>        <span class="fu">value_choices</span>(adsaftte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb8-51"><a href="#cb8-51"></a>        <span class="st">"HYSTTEBL"</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>      ),</span>
+<span id="cb8-53"><a href="#cb8-53"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb8-54"><a href="#cb8-54"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb8-55"><a href="#cb8-55"></a>        <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb8-56"><a href="#cb8-56"></a>      ),</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="dv">0</span>, <span class="cn">NULL</span>),</span>
+<span id="cb8-58"><a href="#cb8-58"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(<span class="st">"EVNTDESC"</span>, <span class="st">"EVNTDESC"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    )</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  )</span>
+<span id="cb8-61"><a href="#cb8-61"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:30:53.8540 pid:12784 token:[] teal.modules.clinical Initializing tm_t_tte</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt11_bl_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt11_bl_cache/html/sessioninfo_2c9db7163517e5b5827829f275ef4291">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt11_bl_cache/html/snapshot_5932a9922400a41ec3da8bb0f264e8e1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-2"><a href="#cb13-2"></a></span>
+<span id="cb13-3"><a href="#cb13-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb13-4"><a href="#cb13-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb13-5"><a href="#cb13-5"></a></span>
+<span id="cb13-6"><a href="#cb13-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb13-7"><a href="#cb13-7"></a></span>
+<span id="cb13-8"><a href="#cb13-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb13-9"><a href="#cb13-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb13-10"><a href="#cb13-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb13-11"><a href="#cb13-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt11_bl.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../tables/lab-results/lbt11.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT11</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt12.html" class="pagination-link">
+        <span class="nav-page-text">LBT12</span> <i class="bi bi-arrow-right-short"></i>
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb14" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb14-1"><a href="#cb14-1"></a><span class="co">---</span></span>
+<span id="cb14-2"><a href="#cb14-2"></a><span class="an">title:</span><span class="co"> LBT11_BL</span></span>
+<span id="cb14-3"><a href="#cb14-3"></a><span class="an">subtitle:</span><span class="co"> Time to First Increase in Liver Laboratory Test Result Meeting Hy's Law Laboratory Critieria (with Respect to Baseline)</span></span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="co">---</span></span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>------------------------------------------------------------------------</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb14-9"><a href="#cb14-9"></a></span>
+<span id="cb14-10"><a href="#cb14-10"></a>::: panel-tabset</span>
+<span id="cb14-11"><a href="#cb14-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb14-12"><a href="#cb14-12"></a></span>
+<span id="cb14-13"><a href="#cb14-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb14-14"><a href="#cb14-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb14-15"><a href="#cb14-15"></a></span>
+<span id="cb14-16"><a href="#cb14-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb14-17"><a href="#cb14-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-18"><a href="#cb14-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb14-19"><a href="#cb14-19"></a></span>
+<span id="cb14-20"><a href="#cb14-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-21"><a href="#cb14-21"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb14-22"><a href="#cb14-22"></a></span>
+<span id="cb14-23"><a href="#cb14-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-24"><a href="#cb14-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-25"><a href="#cb14-25"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb14-26"><a href="#cb14-26"></a></span>
+<span id="cb14-27"><a href="#cb14-27"></a>adsl_safl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-28"><a href="#cb14-28"></a></span>
+<span id="cb14-29"><a href="#cb14-29"></a>anl <span class="ot">&lt;-</span> adsaftte <span class="sc">%&gt;%</span></span>
+<span id="cb14-30"><a href="#cb14-30"></a>  dplyr<span class="sc">::</span><span class="fu">filter</span>(</span>
+<span id="cb14-31"><a href="#cb14-31"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb14-32"><a href="#cb14-32"></a>    PARAMCD <span class="sc">==</span> <span class="st">"HYSTTEBL"</span></span>
+<span id="cb14-33"><a href="#cb14-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-34"><a href="#cb14-34"></a>  dplyr<span class="sc">::</span><span class="fu">mutate</span>(</span>
+<span id="cb14-35"><a href="#cb14-35"></a>    <span class="at">AVAL =</span> .data<span class="sc">$</span>AVAL <span class="sc">*</span> dplyr<span class="sc">::</span><span class="fu">case_when</span>( <span class="co"># convert to days, if possible</span></span>
+<span id="cb14-36"><a href="#cb14-36"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"WEEKS"</span> <span class="sc">~</span> <span class="dv">7</span>,</span>
+<span id="cb14-37"><a href="#cb14-37"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"MONTHS"</span> <span class="sc">~</span> <span class="fl">30.4375</span>,</span>
+<span id="cb14-38"><a href="#cb14-38"></a>      .data<span class="sc">$</span>AVALU <span class="sc">==</span> <span class="st">"YEARS"</span> <span class="sc">~</span> <span class="dv">365</span>,</span>
+<span id="cb14-39"><a href="#cb14-39"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="dv">1</span></span>
+<span id="cb14-40"><a href="#cb14-40"></a>    ),</span>
+<span id="cb14-41"><a href="#cb14-41"></a>    <span class="at">AVALU =</span> <span class="fu">factor</span>(dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb14-42"><a href="#cb14-42"></a>      .data<span class="sc">$</span>AVALU <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"WEEKS"</span>, <span class="st">"MONTHS"</span>, <span class="st">"YEARS"</span>) <span class="sc">~</span> <span class="fu">factor</span>(<span class="st">"DAYS"</span>),</span>
+<span id="cb14-43"><a href="#cb14-43"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> .data<span class="sc">$</span>AVALU</span>
+<span id="cb14-44"><a href="#cb14-44"></a>    ), <span class="at">levels =</span> <span class="st">"DAYS"</span>),</span>
+<span id="cb14-45"><a href="#cb14-45"></a>    <span class="at">is_event =</span> CNSR <span class="sc">==</span> <span class="dv">0</span>, <span class="co"># this will be a LLT event</span></span>
+<span id="cb14-46"><a href="#cb14-46"></a>    <span class="at">event_grp =</span> <span class="fu">factor</span>(</span>
+<span id="cb14-47"><a href="#cb14-47"></a>      dplyr<span class="sc">::</span><span class="fu">case_when</span>(</span>
+<span id="cb14-48"><a href="#cb14-48"></a>        CNSR <span class="sc">==</span> <span class="dv">0</span> <span class="sc">~</span> <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb14-49"><a href="#cb14-49"></a>        CNSR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb14-50"><a href="#cb14-50"></a>      ),</span>
+<span id="cb14-51"><a href="#cb14-51"></a>      <span class="at">levels =</span> <span class="fu">c</span>(</span>
+<span id="cb14-52"><a href="#cb14-52"></a>        <span class="st">"Patients with LLT event (%)"</span>,</span>
+<span id="cb14-53"><a href="#cb14-53"></a>        <span class="st">"Patients without LLT event (%)"</span></span>
+<span id="cb14-54"><a href="#cb14-54"></a>      )</span>
+<span id="cb14-55"><a href="#cb14-55"></a>    )</span>
+<span id="cb14-56"><a href="#cb14-56"></a>  )</span>
+<span id="cb14-57"><a href="#cb14-57"></a><span class="in">```</span></span>
+<span id="cb14-58"><a href="#cb14-58"></a></span>
+<span id="cb14-59"><a href="#cb14-59"></a><span class="fu">## Time-To-Event Summary</span></span>
+<span id="cb14-60"><a href="#cb14-60"></a></span>
+<span id="cb14-61"><a href="#cb14-61"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb14-62"><a href="#cb14-62"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-63"><a href="#cb14-63"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-64"><a href="#cb14-64"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-65"><a href="#cb14-65"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-66"><a href="#cb14-66"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-67"><a href="#cb14-67"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-68"><a href="#cb14-68"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-69"><a href="#cb14-69"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-70"><a href="#cb14-70"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-71"><a href="#cb14-71"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-72"><a href="#cb14-72"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-73"><a href="#cb14-73"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-74"><a href="#cb14-74"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb14-75"><a href="#cb14-75"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb14-76"><a href="#cb14-76"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb14-77"><a href="#cb14-77"></a>  )</span>
+<span id="cb14-78"><a href="#cb14-78"></a></span>
+<span id="cb14-79"><a href="#cb14-79"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-80"><a href="#cb14-80"></a>result</span>
+<span id="cb14-81"><a href="#cb14-81"></a><span class="in">```</span></span>
+<span id="cb14-82"><a href="#cb14-82"></a></span>
+<span id="cb14-83"><a href="#cb14-83"></a><span class="fu">## Time-To-Event Summary &lt;br/&gt; Selecting Sections to Display</span></span>
+<span id="cb14-84"><a href="#cb14-84"></a></span>
+<span id="cb14-85"><a href="#cb14-85"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb14-86"><a href="#cb14-86"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-87"><a href="#cb14-87"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-88"><a href="#cb14-88"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-89"><a href="#cb14-89"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-90"><a href="#cb14-90"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-91"><a href="#cb14-91"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-92"><a href="#cb14-92"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-93"><a href="#cb14-93"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-94"><a href="#cb14-94"></a>  )</span>
+<span id="cb14-95"><a href="#cb14-95"></a></span>
+<span id="cb14-96"><a href="#cb14-96"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-97"><a href="#cb14-97"></a>result</span>
+<span id="cb14-98"><a href="#cb14-98"></a><span class="in">```</span></span>
+<span id="cb14-99"><a href="#cb14-99"></a></span>
+<span id="cb14-100"><a href="#cb14-100"></a><span class="fu">## Time-To-Event Summary &lt;br/&gt; with Stratified Analysis</span></span>
+<span id="cb14-101"><a href="#cb14-101"></a></span>
+<span id="cb14-102"><a href="#cb14-102"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb14-103"><a href="#cb14-103"></a>strata <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb14-104"><a href="#cb14-104"></a></span>
+<span id="cb14-105"><a href="#cb14-105"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-106"><a href="#cb14-106"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARMCD"</span>, <span class="at">ref_group =</span> <span class="st">"ARM A"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-107"><a href="#cb14-107"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"event_grp"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb14-108"><a href="#cb14-108"></a>  <span class="fu">surv_time</span>(</span>
+<span id="cb14-109"><a href="#cb14-109"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-110"><a href="#cb14-110"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Time to 1st LLT Event ("</span>, <span class="fu">levels</span>(anl<span class="sc">$</span>AVALU), <span class="st">")"</span>),</span>
+<span id="cb14-111"><a href="#cb14-111"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-112"><a href="#cb14-112"></a>    <span class="at">table_names =</span> <span class="st">"time_to_event"</span></span>
+<span id="cb14-113"><a href="#cb14-113"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-114"><a href="#cb14-114"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-115"><a href="#cb14-115"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-116"><a href="#cb14-116"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-117"><a href="#cb14-117"></a>    <span class="at">var_labels =</span> <span class="st">"Unstratified Analysis"</span>,</span>
+<span id="cb14-118"><a href="#cb14-118"></a>    <span class="at">control =</span> <span class="fu">control_coxph</span>(<span class="at">pval_method =</span> <span class="st">"log-rank"</span>),</span>
+<span id="cb14-119"><a href="#cb14-119"></a>    <span class="at">table_names =</span> <span class="st">"coxph_unstratified"</span></span>
+<span id="cb14-120"><a href="#cb14-120"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb14-121"><a href="#cb14-121"></a>  <span class="fu">coxph_pairwise</span>(</span>
+<span id="cb14-122"><a href="#cb14-122"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb14-123"><a href="#cb14-123"></a>    <span class="at">is_event =</span> <span class="st">"is_event"</span>,</span>
+<span id="cb14-124"><a href="#cb14-124"></a>    <span class="at">var_labels =</span> <span class="fu">paste0</span>(<span class="st">"Stratified By: "</span>, <span class="fu">paste</span>(strata, <span class="at">collapse =</span> <span class="st">", "</span>)),</span>
+<span id="cb14-125"><a href="#cb14-125"></a>    <span class="at">strat =</span> strata,</span>
+<span id="cb14-126"><a href="#cb14-126"></a>    <span class="at">table_names =</span> <span class="st">"coxph_stratified"</span></span>
+<span id="cb14-127"><a href="#cb14-127"></a>  )</span>
+<span id="cb14-128"><a href="#cb14-128"></a></span>
+<span id="cb14-129"><a href="#cb14-129"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_safl)</span>
+<span id="cb14-130"><a href="#cb14-130"></a>result</span>
+<span id="cb14-131"><a href="#cb14-131"></a><span class="in">```</span></span>
+<span id="cb14-132"><a href="#cb14-132"></a></span>
+<span id="cb14-133"><a href="#cb14-133"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb14-134"><a href="#cb14-134"></a></span>
+<span id="cb14-135"><a href="#cb14-135"></a><span class="fu">## `teal` App</span></span>
+<span id="cb14-136"><a href="#cb14-136"></a></span>
+<span id="cb14-137"><a href="#cb14-137"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb14-138"><a href="#cb14-138"></a><span class="co">#| screenshot.opts = list(delay = 20)</span></span>
+<span id="cb14-139"><a href="#cb14-139"></a></span>
+<span id="cb14-140"><a href="#cb14-140"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb14-141"><a href="#cb14-141"></a><span class="fu">library</span>(scda)</span>
+<span id="cb14-142"><a href="#cb14-142"></a></span>
+<span id="cb14-143"><a href="#cb14-143"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb14-144"><a href="#cb14-144"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adaette"</span>)</span>
+<span id="cb14-145"><a href="#cb14-145"></a></span>
+<span id="cb14-146"><a href="#cb14-146"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb14-147"><a href="#cb14-147"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb14-148"><a href="#cb14-148"></a>adsaftte <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsaftte)</span>
+<span id="cb14-149"><a href="#cb14-149"></a></span>
+<span id="cb14-150"><a href="#cb14-150"></a>adsl <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsl, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-151"><a href="#cb14-151"></a>adsaftte <span class="ot">&lt;-</span> dplyr<span class="sc">::</span><span class="fu">filter</span>(adsaftte, .data<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb14-152"><a href="#cb14-152"></a></span>
+<span id="cb14-153"><a href="#cb14-153"></a>arm_ref_comp <span class="ot">&lt;-</span> <span class="fu">list</span>(</span>
+<span id="cb14-154"><a href="#cb14-154"></a>  <span class="at">ACTARMCD =</span> <span class="fu">list</span>(</span>
+<span id="cb14-155"><a href="#cb14-155"></a>    <span class="at">ref =</span> <span class="st">"ARM B"</span>,</span>
+<span id="cb14-156"><a href="#cb14-156"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"ARM A"</span>, <span class="st">"ARM C"</span>)</span>
+<span id="cb14-157"><a href="#cb14-157"></a>  ),</span>
+<span id="cb14-158"><a href="#cb14-158"></a>  <span class="at">ARM =</span> <span class="fu">list</span>(</span>
+<span id="cb14-159"><a href="#cb14-159"></a>    <span class="at">ref =</span> <span class="st">"B: Placebo"</span>,</span>
+<span id="cb14-160"><a href="#cb14-160"></a>    <span class="at">comp =</span> <span class="fu">c</span>(<span class="st">"A: Drug X"</span>, <span class="st">"C: Combination"</span>)</span>
+<span id="cb14-161"><a href="#cb14-161"></a>  )</span>
+<span id="cb14-162"><a href="#cb14-162"></a>)</span>
+<span id="cb14-163"><a href="#cb14-163"></a></span>
+<span id="cb14-164"><a href="#cb14-164"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb14-165"><a href="#cb14-165"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb14-166"><a href="#cb14-166"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-167"><a href="#cb14-167"></a>      <span class="st">"ADSL"</span>,</span>
+<span id="cb14-168"><a href="#cb14-168"></a>      adsl,</span>
+<span id="cb14-169"><a href="#cb14-169"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb14-170"><a href="#cb14-170"></a>    ),</span>
+<span id="cb14-171"><a href="#cb14-171"></a>    <span class="fu">cdisc_dataset</span>(</span>
+<span id="cb14-172"><a href="#cb14-172"></a>      <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb14-173"><a href="#cb14-173"></a>      adsaftte,</span>
+<span id="cb14-174"><a href="#cb14-174"></a>      <span class="at">keys =</span> <span class="fu">c</span>(<span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>, <span class="st">"PARAMCD"</span>),</span>
+<span id="cb14-175"><a href="#cb14-175"></a>      <span class="at">code =</span> <span class="st">'ADSAFTTE &lt;- synthetic_cdisc_dataset("latest", "adaette") %&gt;% df_explicit_na() %&gt;% dplyr::filter(.data$SAFFL == "Y")'</span></span>
+<span id="cb14-176"><a href="#cb14-176"></a>    ),</span>
+<span id="cb14-177"><a href="#cb14-177"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb14-178"><a href="#cb14-178"></a>  ),</span>
+<span id="cb14-179"><a href="#cb14-179"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb14-180"><a href="#cb14-180"></a>    <span class="fu">tm_t_tte</span>(</span>
+<span id="cb14-181"><a href="#cb14-181"></a>      <span class="at">label =</span> <span class="st">"Time To LLT Event Table"</span>,</span>
+<span id="cb14-182"><a href="#cb14-182"></a>      <span class="at">dataname =</span> <span class="st">"ADSAFTTE"</span>,</span>
+<span id="cb14-183"><a href="#cb14-183"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-184"><a href="#cb14-184"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>, <span class="st">"ACTARMCD"</span>)),</span>
+<span id="cb14-185"><a href="#cb14-185"></a>        <span class="st">"ARM"</span></span>
+<span id="cb14-186"><a href="#cb14-186"></a>      ),</span>
+<span id="cb14-187"><a href="#cb14-187"></a>      <span class="at">arm_ref_comp =</span> arm_ref_comp,</span>
+<span id="cb14-188"><a href="#cb14-188"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-189"><a href="#cb14-189"></a>        <span class="fu">value_choices</span>(adsaftte, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb14-190"><a href="#cb14-190"></a>        <span class="st">"HYSTTEBL"</span></span>
+<span id="cb14-191"><a href="#cb14-191"></a>      ),</span>
+<span id="cb14-192"><a href="#cb14-192"></a>      <span class="at">strata_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb14-193"><a href="#cb14-193"></a>        <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb14-194"><a href="#cb14-194"></a>        <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"SEX"</span>)</span>
+<span id="cb14-195"><a href="#cb14-195"></a>      ),</span>
+<span id="cb14-196"><a href="#cb14-196"></a>      <span class="at">time_points =</span> <span class="fu">choices_selected</span>(<span class="dv">0</span>, <span class="cn">NULL</span>),</span>
+<span id="cb14-197"><a href="#cb14-197"></a>      <span class="at">event_desc_var =</span> <span class="fu">choices_selected</span>(<span class="st">"EVNTDESC"</span>, <span class="st">"EVNTDESC"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-198"><a href="#cb14-198"></a>    )</span>
+<span id="cb14-199"><a href="#cb14-199"></a>  )</span>
+<span id="cb14-200"><a href="#cb14-200"></a>)</span>
+<span id="cb14-201"><a href="#cb14-201"></a></span>
+<span id="cb14-202"><a href="#cb14-202"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb14-203"><a href="#cb14-203"></a><span class="in">```</span></span>
+<span id="cb14-204"><a href="#cb14-204"></a></span>
+<span id="cb14-205"><a href="#cb14-205"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb14-206"><a href="#cb14-206"></a></span>
+<span id="cb14-207"><a href="#cb14-207"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Adverse Events</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
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+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+ <span class="menu-text">Disclosures</span></a>
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+ <span class="menu-text">DISCLOSUREST01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT12</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to ULN)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt12_cache/html/setup_02fd244bf55b7e84e868bfa21ef51158">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>anl <span class="ot">&lt;-</span> adhy</span>
+<span id="cb1-8"><a href="#cb1-8"></a>anl<span class="sc">$</span>APERIODC <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>APERIODC) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>anl<span class="sc">$</span>ACTARM <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>ACTARM) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASTPULN"</span>, <span class="st">"ALTPULN"</span>, <span class="st">"ALTASTPU"</span>) <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE"</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">ARM_AVALC =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>        AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="fu">as.character</span>(ACTARM),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>      ),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="fu">levels</span>(anl<span class="sc">$</span>ACTARM), <span class="st">"Criteria not met"</span>)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    ),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ASTPULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;3x ULN"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTPULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3x ULN"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTASTPU"</span> <span class="sc">~</span> <span class="st">"AST &gt;3x ULN or ALT &gt;x3 ULN"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>      ),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"AST &gt;3x ULN"</span>, <span class="st">"ALT &gt;3x ULN"</span>, <span class="st">"AST &gt;3x ULN or ALT &gt;x3 ULN"</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    ),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">TITLE =</span> <span class="fu">factor</span>(<span class="st">"First Elevated Result Occurring During"</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  )</span>
+<span id="cb1-34"><a href="#cb1-34"></a></span>
+<span id="cb1-35"><a href="#cb1-35"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt12_cache/html/variant1_40ab30e4975f3ae6ccc52aeab0cfba5b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"TITLE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(<span class="st">"APERIODC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">count_occurrences</span>(<span class="st">"ARM_AVALC"</span>, <span class="at">.stats =</span> <span class="st">"fraction"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">build_table</span>(anl)</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  dplyr<span class="sc">::</span><span class="fu">if_else</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>}</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                              First Elevated Result Occurring During  
+                                  PERIOD 1              PERIOD 2      
+——————————————————————————————————————————————————————————————————————
+AST &gt;3x ULN                                                           
+  A: Drug X                     11/134 (8.2%)        21/134 (15.7%)   
+  B: Placebo                   17/134 (12.7%)        16/134 (11.9%)   
+  C: Combination                10/132 (7.6%)         8/132 (6.1%)    
+ALT &gt;3x ULN                                                           
+  A: Drug X                    14/134 (10.4%)         8/134 (6.0%)    
+  B: Placebo                   24/134 (17.9%)        18/134 (13.4%)   
+  C: Combination               16/132 (12.1%)         10/132 (7.6%)   
+AST &gt;3x ULN or ALT &gt;x3 ULN                                            
+  A: Drug X                    14/134 (10.4%)        15/134 (11.2%)   
+  B: Placebo                    8/134 (6.0%)          13/134 (9.7%)   
+  C: Combination                11/132 (8.3%)         12/132 (9.1%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt12_cache/html/teal_19429ca4f1bc46de88dea13d20c02321">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt12_cache/html/sessioninfo_fdd273d4e83ab648e1e7d688cf89fc66">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt12_cache/html/snapshot_23ef12aea7fb8454a46eea052b8c1f7e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt12.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
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+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
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+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+        }
+      }
+      return codeEl.innerText;
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+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
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+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
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+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
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+      }
+  const findCites = (el) => {
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt11_bl.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT11_BL</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt12_bl.html" class="pagination-link">
+        <span class="nav-page-text">LBT12_BL</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> LBT12</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Liver Laboratory Tests by Time on Treatment -- Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to ULN)</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>anl <span class="ot">&lt;-</span> adhy</span>
+<span id="cb8-23"><a href="#cb8-23"></a>anl<span class="sc">$</span>APERIODC <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>APERIODC) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>anl<span class="sc">$</span>ACTARM <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>ACTARM) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASTPULN"</span>, <span class="st">"ALTPULN"</span>, <span class="st">"ALTASTPU"</span>) <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE"</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="at">ARM_AVALC =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-33"><a href="#cb8-33"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>        AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="fu">as.character</span>(ACTARM),</span>
+<span id="cb8-35"><a href="#cb8-35"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>      ),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="fu">levels</span>(anl<span class="sc">$</span>ACTARM), <span class="st">"Criteria not met"</span>)</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    ),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-40"><a href="#cb8-40"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ASTPULN"</span> <span class="sc">~</span> <span class="st">"AST &gt;3x ULN"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTPULN"</span> <span class="sc">~</span> <span class="st">"ALT &gt;3x ULN"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTASTPU"</span> <span class="sc">~</span> <span class="st">"AST &gt;3x ULN or ALT &gt;x3 ULN"</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>      ),</span>
+<span id="cb8-45"><a href="#cb8-45"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"AST &gt;3x ULN"</span>, <span class="st">"ALT &gt;3x ULN"</span>, <span class="st">"AST &gt;3x ULN or ALT &gt;x3 ULN"</span>)</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    ),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">TITLE =</span> <span class="fu">factor</span>(<span class="st">"First Elevated Result Occurring During"</span>)</span>
+<span id="cb8-48"><a href="#cb8-48"></a>  )</span>
+<span id="cb8-49"><a href="#cb8-49"></a></span>
+<span id="cb8-50"><a href="#cb8-50"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span>
+<span id="cb8-51"><a href="#cb8-51"></a><span class="in">```</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a></span>
+<span id="cb8-53"><a href="#cb8-53"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a></span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">split_cols_by</span>(<span class="st">"TITLE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  <span class="fu">split_cols_by</span>(<span class="st">"APERIODC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">count_occurrences</span>(<span class="st">"ARM_AVALC"</span>, <span class="at">.stats =</span> <span class="st">"fraction"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  <span class="fu">build_table</span>(anl)</span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb8-66"><a href="#cb8-66"></a>  dplyr<span class="sc">::</span><span class="fu">if_else</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb8-67"><a href="#cb8-67"></a>}</span>
+<span id="cb8-68"><a href="#cb8-68"></a></span>
+<span id="cb8-69"><a href="#cb8-69"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb8-70"><a href="#cb8-70"></a>result</span>
+<span id="cb8-71"><a href="#cb8-71"></a><span class="in">```</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-74"><a href="#cb8-74"></a></span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a></span>
+<span id="cb8-80"><a href="#cb8-80"></a><span class="co"># In progress</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a><span class="in">```</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a></span>
+<span id="cb8-83"><a href="#cb8-83"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-84"><a href="#cb8-84"></a></span>
+<span id="cb8-85"><a href="#cb8-85"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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new file mode 100644
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--- /dev/null
+++ b/stable/tables/lab-results/lbt12_bl.html
@@ -0,0 +1,2105 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+.sourceCode { overflow: visible; }
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+div.sourceCode { overflow: auto; }
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+pre > code.sourceCode { white-space: pre-wrap; }
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+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
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+ <span class="menu-text">Disposition</span></a>
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
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+ <span class="menu-text">Efficacy</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT12_BL</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to Baseline)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="lbt12_bl_cache/html/setup_bbbecee2c9d7a107ce56bf2b502cfe86">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>anl <span class="ot">&lt;-</span> adhy</span>
+<span id="cb1-8"><a href="#cb1-8"></a>anl<span class="sc">$</span>APERIODC <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>APERIODC) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>anl<span class="sc">$</span>ACTARM <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>ACTARM) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASTPBASE"</span>, <span class="st">"ALTPBASE"</span>, <span class="st">"ALTASTPB"</span>) <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE"</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">ARM_AVALC =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>        AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="fu">as.character</span>(ACTARM),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>      ),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="fu">levels</span>(anl<span class="sc">$</span>ACTARM), <span class="st">"Criteria not met"</span>)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    ),</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ASTPBASE"</span> <span class="sc">~</span> <span class="st">"AST&gt;3x Baseline"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTPBASE"</span> <span class="sc">~</span> <span class="st">"ALT&gt;3x Baseline"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTASTPB"</span> <span class="sc">~</span> <span class="st">"AST&gt;3x Baseline or ALT&gt;3x Baseline"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>      ),</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"AST&gt;3x Baseline"</span>, <span class="st">"ALT&gt;3x Baseline"</span>, <span class="st">"AST&gt;3x Baseline or ALT&gt;3x Baseline"</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    ),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">TITLE =</span> <span class="fu">factor</span>(<span class="st">"First Elevated Result Occurring During"</span>)</span>
+<span id="cb1-33"><a href="#cb1-33"></a>  )</span>
+<span id="cb1-34"><a href="#cb1-34"></a></span>
+<span id="cb1-35"><a href="#cb1-35"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt12_bl_cache/html/variant1_6a611db3c950ac0e8d13cf703911cfe1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"TITLE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(<span class="st">"APERIODC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">count_occurrences</span>(<span class="st">"ARM_AVALC"</span>, <span class="at">.stats =</span> <span class="st">"fraction"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">build_table</span>(anl)</span>
+<span id="cb2-8"><a href="#cb2-8"></a></span>
+<span id="cb2-9"><a href="#cb2-9"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb2-11"><a href="#cb2-11"></a>  dplyr<span class="sc">::</span><span class="fu">if_else</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>}</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                      First Elevated Result Occurring During  
+                                          PERIOD 1              PERIOD 2      
+——————————————————————————————————————————————————————————————————————————————
+AST&gt;3x Baseline                                                               
+  A: Drug X                            14/134 (10.4%)         8/134 (6.0%)    
+  B: Placebo                            11/134 (8.2%)         11/134 (8.2%)   
+  C: Combination                       15/132 (11.4%)        14/132 (10.6%)   
+ALT&gt;3x Baseline                                                               
+  A: Drug X                             7/134 (5.2%)         20/134 (14.9%)   
+  B: Placebo                            10/134 (7.5%)         9/134 (6.7%)    
+  C: Combination                        12/132 (9.1%)         8/132 (6.1%)    
+AST&gt;3x Baseline or ALT&gt;3x Baseline                                            
+  A: Drug X                             8/134 (6.0%)         22/134 (16.4%)   
+  B: Placebo                           19/134 (14.2%)        15/134 (11.2%)   
+  C: Combination                       14/132 (10.6%)         13/132 (9.8%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="lbt12_bl_cache/html/teal_bcc38460670cb70d682422cc4e29195e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt12_bl_cache/html/sessioninfo_184e00ac6d8f1bc68660f319f12489b6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt12_bl_cache/html/snapshot_b0236f3560aad108003f49f6dfb7ecff">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt12_bl.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+  const anchorJS = new window.AnchorJS();
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+        return true;
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+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
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+        }
+      }
+      return codeEl.innerText;
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+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
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+    // flash "checked"
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+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt12.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT12</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt13.html" class="pagination-link">
+        <span class="nav-page-text">LBT13</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> LBT12_BL</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Liver Laboratory Tests by Time on Treatment -- Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to Baseline)</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adhy <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adhy"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>anl <span class="ot">&lt;-</span> adhy</span>
+<span id="cb8-23"><a href="#cb8-23"></a>anl<span class="sc">$</span>APERIODC <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>APERIODC) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>anl<span class="sc">$</span>ACTARM <span class="ot">&lt;-</span> <span class="fu">as.factor</span>(anl<span class="sc">$</span>ACTARM) <span class="co"># to ensure the table is built even if there is no patients after filtering</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a>anl <span class="ot">&lt;-</span> anl <span class="sc">%&gt;%</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-28"><a href="#cb8-28"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>    PARAMCD <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"ASTPBASE"</span>, <span class="st">"ALTPBASE"</span>, <span class="st">"ALTASTPB"</span>) <span class="sc">&amp;</span> AVISIT <span class="sc">==</span> <span class="st">"POST-BASELINE"</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="at">ARM_AVALC =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-33"><a href="#cb8-33"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb8-34"><a href="#cb8-34"></a>        AVALC <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">~</span> <span class="fu">as.character</span>(ACTARM),</span>
+<span id="cb8-35"><a href="#cb8-35"></a>        <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"Criteria not met"</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>      ),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="fu">levels</span>(anl<span class="sc">$</span>ACTARM), <span class="st">"Criteria not met"</span>)</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    ),</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">PARAM =</span> <span class="fu">factor</span>(</span>
+<span id="cb8-40"><a href="#cb8-40"></a>      <span class="fu">case_when</span>(</span>
+<span id="cb8-41"><a href="#cb8-41"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ASTPBASE"</span> <span class="sc">~</span> <span class="st">"AST&gt;3x Baseline"</span>,</span>
+<span id="cb8-42"><a href="#cb8-42"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTPBASE"</span> <span class="sc">~</span> <span class="st">"ALT&gt;3x Baseline"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>        PARAMCD <span class="sc">==</span> <span class="st">"ALTASTPB"</span> <span class="sc">~</span> <span class="st">"AST&gt;3x Baseline or ALT&gt;3x Baseline"</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>      ),</span>
+<span id="cb8-45"><a href="#cb8-45"></a>      <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"AST&gt;3x Baseline"</span>, <span class="st">"ALT&gt;3x Baseline"</span>, <span class="st">"AST&gt;3x Baseline or ALT&gt;3x Baseline"</span>)</span>
+<span id="cb8-46"><a href="#cb8-46"></a>    ),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">TITLE =</span> <span class="fu">factor</span>(<span class="st">"First Elevated Result Occurring During"</span>)</span>
+<span id="cb8-48"><a href="#cb8-48"></a>  )</span>
+<span id="cb8-49"><a href="#cb8-49"></a></span>
+<span id="cb8-50"><a href="#cb8-50"></a>anl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(anl)</span>
+<span id="cb8-51"><a href="#cb8-51"></a><span class="in">```</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a></span>
+<span id="cb8-53"><a href="#cb8-53"></a><span class="fu">## Standard Table</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a></span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-57"><a href="#cb8-57"></a>  <span class="fu">split_cols_by</span>(<span class="st">"TITLE"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  <span class="fu">split_cols_by</span>(<span class="st">"APERIODC"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-59"><a href="#cb8-59"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-60"><a href="#cb8-60"></a>  <span class="fu">split_rows_by</span>(<span class="st">"ACTARM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">child_labels =</span> <span class="st">"hidden"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-61"><a href="#cb8-61"></a>  <span class="fu">count_occurrences</span>(<span class="st">"ARM_AVALC"</span>, <span class="at">.stats =</span> <span class="st">"fraction"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  <span class="fu">build_table</span>(anl)</span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a>criteria_fun <span class="ot">&lt;-</span> <span class="cf">function</span>(tr) {</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  row_label <span class="ot">&lt;-</span> <span class="fu">obj_label</span>(tr)</span>
+<span id="cb8-66"><a href="#cb8-66"></a>  dplyr<span class="sc">::</span><span class="fu">if_else</span>(row_label <span class="sc">==</span> <span class="st">"Criteria not met"</span>, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)</span>
+<span id="cb8-67"><a href="#cb8-67"></a>}</span>
+<span id="cb8-68"><a href="#cb8-68"></a></span>
+<span id="cb8-69"><a href="#cb8-69"></a>result <span class="ot">&lt;-</span> result <span class="sc">%&gt;%</span> <span class="fu">trim_rows</span>(<span class="at">criteria =</span> criteria_fun)</span>
+<span id="cb8-70"><a href="#cb8-70"></a>result</span>
+<span id="cb8-71"><a href="#cb8-71"></a><span class="in">```</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a></span>
+<span id="cb8-73"><a href="#cb8-73"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-74"><a href="#cb8-74"></a></span>
+<span id="cb8-75"><a href="#cb8-75"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-78"><a href="#cb8-78"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-79"><a href="#cb8-79"></a></span>
+<span id="cb8-80"><a href="#cb8-80"></a><span class="co"># In progress</span></span>
+<span id="cb8-81"><a href="#cb8-81"></a><span class="in">```</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a></span>
+<span id="cb8-83"><a href="#cb8-83"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-84"><a href="#cb8-84"></a></span>
+<span id="cb8-85"><a href="#cb8-85"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/tables/lab-results/lbt13.html b/stable/tables/lab-results/lbt13.html
new file mode 100644
index 0000000000..9326370cfd
--- /dev/null
+++ b/stable/tables/lab-results/lbt13.html
@@ -0,0 +1,3584 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT13</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/lab-results/lbt14.html" rel="next">
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+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
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+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT13</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">NCI CTCAE Grade Laboratory Abnormalities by Visit and Baseline Grade</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table (Low)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Standard Table (High)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Without Patients with <br> Missing Baseline (Low)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Missing Baseline <br> Considered as Grade 0 (High)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table with Fill-In <br> of Grades (High)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>Please note that for each variant, the <code>adlb</code> dataset needs to be filtered on correct flags like <code>WGRLOVFL</code>, <code>WGRHIVFL</code>, et al., otherwise the layout function will not return the correct counts. There is an option to create a record for a lab test where no record is found at that visit. If you specified <code>add_derived_type = "PHANTOM"</code> &amp; <code>dtype_phantom_cond</code>, you don’t have to use the <code>h_adsl_adlb_merge_using_worst_flag</code> function to preprocess your <code>adlb</code> dataset. Otherwise please follow the pre-processing steps below before applying the layout functions.</p>
+<div class="cell" data-hash="lbt13_cache/html/setup_c4f693c60ce74dca8943e93396e4766e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># selected properly.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>Note that the worst laboratory flag (below <code>WGRLOVFL</code>) must be selected appropriately to match the direction of abnormality (here <code>Low</code>). New grouping variables <code>ATOXGR_GP</code> and <code>BTOXGR_GP</code> are created to display the correct output.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt13_cache/html/variant1_21d2f2d91fd0375afd781132b715f4b5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    adlb_f,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb2-10"><a href="#cb2-10"></a>  )</span>
+<span id="cb2-11"><a href="#cb2-11"></a></span>
+<span id="cb2-12"><a href="#cb2-12"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>    )</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>    )</span>
+<span id="cb2-33"><a href="#cb2-33"></a>  )</span>
+<span id="cb2-34"><a href="#cb2-34"></a></span>
+<span id="cb2-35"><a href="#cb2-35"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb2-39"><a href="#cb2-39"></a>)</span>
+<span id="cb2-40"><a href="#cb2-40"></a></span>
+<span id="cb2-41"><a href="#cb2-41"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb2-44"><a href="#cb2-44"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb2-46"><a href="#cb2-46"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a>  )</span>
+<span id="cb2-48"><a href="#cb2-48"></a></span>
+<span id="cb2-49"><a href="#cb2-49"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-50"><a href="#cb2-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-51"><a href="#cb2-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-52"><a href="#cb2-52"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb2-53"><a href="#cb2-53"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb2-54"><a href="#cb2-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-55"><a href="#cb2-55"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-56"><a href="#cb2-56"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb2-57"><a href="#cb2-57"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb2-58"><a href="#cb2-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-59"><a href="#cb2-59"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-60"><a href="#cb2-60"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb2-61"><a href="#cb2-61"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb2-62"><a href="#cb2-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-63"><a href="#cb2-63"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-64"><a href="#cb2-64"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-65"><a href="#cb2-65"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-66"><a href="#cb2-66"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb2-67"><a href="#cb2-67"></a></span>
+<span id="cb2-68"><a href="#cb2-68"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                             
+  Visit                                                                    
+    NCI CTCAE Grade at Visit      A: Drug X    B: Placebo    C: Combination
+      Baseline NCI CTCAE Grade     (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————
+CRP                                                                        
+  WEEK 1 DAY 8                                                             
+    Not Low (n)                      116           110            101      
+      Not Low                    103 (88.8%)   91 (82.7%)      88 (87.1%)  
+      1                           3 (2.6%)      5 (4.5%)        6 (5.9%)   
+      2                           4 (3.4%)      9 (8.2%)        2 (2.0%)   
+      3                           3 (2.6%)      4 (3.6%)        4 (4.0%)   
+      4                           3 (2.6%)      1 (0.9%)        1 (1.0%)   
+    1 (n)                             4             7              5       
+      Not Low                     3 (75.0%)     7 (100%)       4 (80.0%)   
+      3                           1 (25.0%)         0          1 (20.0%)   
+    2 (n)                             5             6              11      
+      Not Low                     5 (100%)      5 (83.3%)      8 (72.7%)   
+      1                               0             0           1 (9.1%)   
+      3                               0             0          2 (18.2%)   
+      4                               0         1 (16.7%)          0       
+    3 (n)                             6             8              5       
+      Not Low                     6 (100%)      7 (87.5%)       5 (100%)   
+      3                               0         1 (12.5%)          0       
+    4 (n)                             3             3              10      
+      Not Low                     2 (66.7%)     3 (100%)       7 (70.0%)   
+      1                               0             0          2 (20.0%)   
+      2                           1 (33.3%)         0              0       
+      4                               0             0          1 (10.0%)   
+  WEEK 2 DAY 15                                                            
+    Not Low (n)                      106           111            116      
+      Not Low                    93 (87.7%)    93 (83.8%)     100 (86.2%)  
+      1                           3 (2.8%)      4 (3.6%)        8 (6.9%)   
+      2                           5 (4.7%)      7 (6.3%)        2 (1.7%)   
+      3                           2 (1.9%)      5 (4.5%)        6 (5.2%)   
+      4                           3 (2.8%)      2 (1.8%)           0       
+    1 (n)                            15             9              2       
+      Not Low                    13 (86.7%)     8 (88.9%)      1 (50.0%)   
+      2                               0         1 (11.1%)          0       
+      3                           2 (13.3%)         0              0       
+      4                               0             0          1 (50.0%)   
+    2 (n)                             3             3              6       
+      Not Low                     3 (100%)      3 (100%)       4 (66.7%)   
+      1                               0             0          1 (16.7%)   
+      3                               0             0          1 (16.7%)   
+    3 (n)                             7             7              6       
+      Not Low                     7 (100%)      6 (85.7%)      5 (83.3%)   
+      2                               0         1 (14.3%)          0       
+      4                               0             0          1 (16.7%)   
+    4 (n)                             3             4              2       
+      Not Low                     3 (100%)      3 (75.0%)       2 (100%)   
+      1                               0         1 (25.0%)          0       
+  WEEK 3 DAY 22                                                            
+    Not Low (n)                      119           110            114      
+      Not Low                    104 (87.4%)   92 (83.6%)      94 (82.5%)  
+      1                           3 (2.5%)      4 (3.6%)        9 (7.9%)   
+      2                           5 (4.2%)      7 (6.4%)        2 (1.8%)   
+      3                           4 (3.4%)      5 (4.5%)        7 (6.1%)   
+      4                           3 (2.5%)      2 (1.8%)        2 (1.8%)   
+    1 (n)                             9             9              6       
+      Not Low                     9 (100%)      7 (77.8%)       6 (100%)   
+      2                               0         2 (22.2%)          0       
+    2 (n)                             1             7              3       
+      Not Low                     1 (100%)      6 (85.7%)       3 (100%)   
+      1                               0         1 (14.3%)          0       
+    3 (n)                             4             5              4       
+      Not Low                     4 (100%)      5 (100%)        4 (100%)   
+    4 (n)                             1             3              5       
+      Not Low                     1 (100%)      3 (100%)        5 (100%)   
+  WEEK 4 DAY 29                                                            
+    Not Low (n)                      101           119            111      
+      Not Low                    89 (88.1%)    100 (84.0%)     96 (86.5%)  
+      1                           3 (3.0%)      4 (3.4%)        6 (5.4%)   
+      2                           4 (4.0%)      8 (6.7%)        1 (0.9%)   
+      3                           2 (2.0%)      5 (4.2%)        6 (5.4%)   
+      4                           3 (3.0%)      2 (1.7%)        2 (1.8%)   
+    1 (n)                            10             5              6       
+      Not Low                     9 (90.0%)     5 (100%)       5 (83.3%)   
+      1                               0             0          1 (16.7%)   
+      2                           1 (10.0%)         0              0       
+    2 (n)                            13             4              6       
+      Not Low                     13 (100%)     3 (75.0%)      5 (83.3%)   
+      1                               0             0          1 (16.7%)   
+      2                               0         1 (25.0%)          0       
+    3 (n)                             8             2              6       
+      Not Low                     6 (75.0%)     1 (50.0%)      5 (83.3%)   
+      1                               0         1 (50.0%)          0       
+      2                               0             0          1 (16.7%)   
+      3                           2 (25.0%)         0              0       
+    4 (n)                             2             4              3       
+      Not Low                     2 (100%)      4 (100%)       1 (33.3%)   
+      1                               0             0          1 (33.3%)   
+      3                               0             0          1 (33.3%)   
+  WEEK 5 DAY 36                                                            
+    Not Low (n)                      115           112            111      
+      Not Low                    102 (88.7%)   94 (83.9%)      96 (86.5%)  
+      1                           2 (1.7%)      4 (3.6%)        6 (5.4%)   
+      2                           5 (4.3%)      7 (6.2%)        2 (1.8%)   
+      3                           3 (2.6%)      5 (4.5%)        5 (4.5%)   
+      4                           3 (2.6%)      2 (1.8%)        2 (1.8%)   
+    1 (n)                             5             7              6       
+      Not Low                     5 (100%)      4 (57.1%)      5 (83.3%)   
+      1                               0         1 (14.3%)      1 (16.7%)   
+      2                               0         2 (28.6%)          0       
+    2 (n)                             5            11              6       
+      Not Low                     5 (100%)      11 (100%)       6 (100%)   
+    3 (n)                             8             2              7       
+      Not Low                     6 (75.0%)     2 (100%)       4 (57.1%)   
+      1                           1 (12.5%)         0          1 (14.3%)   
+      3                           1 (12.5%)         0          2 (28.6%)   
+    4 (n)                             1             2              2       
+      Not Low                     1 (100%)      2 (100%)       1 (50.0%)   
+      1                               0             0          1 (50.0%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Note that the worst laboratory flag (below <code>WGRHIVFL</code>) must be selected appropriately to match the direction of abnormality (here <code>High</code>). New grouping variables <code>ATOXGR_GP</code> and <code>BTOXGR_GP</code> are created to display the correct output.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt13_cache/html/variant2_64d4aaf96ff2f697738c0d943afc4e9f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    adlb_f,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  )</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb4-13"><a href="#cb4-13"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb4-16"><a href="#cb4-16"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb4-17"><a href="#cb4-17"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb4-18"><a href="#cb4-18"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb4-19"><a href="#cb4-19"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb4-22"><a href="#cb4-22"></a>    )</span>
+<span id="cb4-23"><a href="#cb4-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb4-29"><a href="#cb4-29"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb4-30"><a href="#cb4-30"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb4-31"><a href="#cb4-31"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>    )</span>
+<span id="cb4-33"><a href="#cb4-33"></a>  )</span>
+<span id="cb4-34"><a href="#cb4-34"></a></span>
+<span id="cb4-35"><a href="#cb4-35"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb4-39"><a href="#cb4-39"></a>)</span>
+<span id="cb4-40"><a href="#cb4-40"></a></span>
+<span id="cb4-41"><a href="#cb4-41"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb4-42"><a href="#cb4-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb4-43"><a href="#cb4-43"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb4-45"><a href="#cb4-45"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb4-46"><a href="#cb4-46"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  )</span>
+<span id="cb4-48"><a href="#cb4-48"></a></span>
+<span id="cb4-49"><a href="#cb4-49"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-50"><a href="#cb4-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-52"><a href="#cb4-52"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb4-54"><a href="#cb4-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-56"><a href="#cb4-56"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb4-57"><a href="#cb4-57"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb4-58"><a href="#cb4-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-59"><a href="#cb4-59"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-60"><a href="#cb4-60"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb4-61"><a href="#cb4-61"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb4-62"><a href="#cb4-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-63"><a href="#cb4-63"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-64"><a href="#cb4-64"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-65"><a href="#cb4-65"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-66"><a href="#cb4-66"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb4-67"><a href="#cb4-67"></a></span>
+<span id="cb4-68"><a href="#cb4-68"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                            
+  Visit                                                                   
+    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination
+      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————
+CRP                                                                       
+  WEEK 1 DAY 8                                                            
+    Not High (n)                    111           110            112      
+      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  
+      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   
+      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   
+      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   
+      4                           2 (1.8%)     2 (1.8%)           0       
+    1 (n)                            8            11              6       
+      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   
+      3                          1 (12.5%)         0          1 (16.7%)   
+    2 (n)                            6             4              5       
+      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   
+      1                              0         3 (75.0%)      1 (20.0%)   
+    3 (n)                            8             3              4       
+      Not High                   7 (87.5%)     3 (100%)        4 (100%)   
+      4                          1 (12.5%)         0              0       
+    4 (n)                            1             6              5       
+      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   
+      1                              0             0          1 (20.0%)   
+      3                              0         1 (16.7%)          0       
+  WEEK 2 DAY 15                                                           
+    Not High (n)                    117           113            113      
+      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  
+      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   
+      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   
+      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   
+      4                           3 (2.6%)     2 (1.8%)           0       
+    1 (n)                            6             9              7       
+      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   
+      1                              0         1 (11.1%)          0       
+      2                              0             0          1 (14.3%)   
+      3                          1 (16.7%)         0              0       
+    2 (n)                            4             4              6       
+      Not High                    4 (100%)     4 (100%)       3 (50.0%)   
+      1                              0             0          3 (50.0%)   
+    3 (n)                            5             3              5       
+      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   
+      1                          1 (20.0%)     1 (33.3%)          0       
+    4 (n)                            2             5              1       
+      Not High                    2 (100%)     3 (60.0%)       1 (100%)   
+      1                              0         2 (40.0%)          0       
+  WEEK 3 DAY 22                                                           
+    Not High (n)                    110           111            114      
+      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  
+      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   
+      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   
+      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+    1 (n)                            7             8              7       
+      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   
+      1                              0         1 (12.5%)          0       
+      2                              0         1 (12.5%)      1 (14.3%)   
+      3                              0         1 (12.5%)          0       
+    2 (n)                            9             7              5       
+      Not High                    9 (100%)     6 (85.7%)       5 (100%)   
+      3                              0         1 (14.3%)          0       
+    3 (n)                            6             3              4       
+      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   
+      3                          1 (16.7%)         0              0       
+      4                              0         1 (33.3%)          0       
+    4 (n)                            2             5              2       
+      Not High                   1 (50.0%)     5 (100%)        2 (100%)   
+      3                          1 (50.0%)         0              0       
+  WEEK 4 DAY 29                                                           
+    Not High (n)                    115           117            113      
+      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  
+      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   
+      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   
+      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   
+      4                           1 (0.9%)         0              0       
+    1 (n)                            4             3              11      
+      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  
+      2                              0             0           1 (9.1%)   
+      4                              0         1 (33.3%)          0       
+    2 (n)                            6             4              2       
+      Not High                    6 (100%)     3 (75.0%)       2 (100%)   
+      1                              0         1 (25.0%)          0       
+    3 (n)                            6             7              4       
+      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   
+      1                              0         1 (14.3%)          0       
+      3                              0         1 (14.3%)          0       
+      4                          1 (16.7%)     1 (14.3%)          0       
+    4 (n)                            3             3              2       
+      Not High                   2 (66.7%)     2 (66.7%)          0       
+      1                              0         1 (33.3%)      1 (50.0%)   
+      2                              0             0          1 (50.0%)   
+      4                          1 (33.3%)         0              0       
+  WEEK 5 DAY 36                                                           
+    Not High (n)                    111           111            119      
+      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  
+      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   
+      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   
+      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+    1 (n)                            8            11              5       
+      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   
+      1                              0         1 (9.1%)           0       
+      2                              0             0          1 (20.0%)   
+      3                          1 (12.5%)     1 (9.1%)           0       
+    2 (n)                            7             6              3       
+      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   
+      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   
+      2                          1 (14.3%)     1 (16.7%)          0       
+      4                              0         1 (16.7%)          0       
+    3 (n)                            3             3              4       
+      Not High                    3 (100%)     3 (100%)        4 (100%)   
+    4 (n)                            5             3              1       
+      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   
+      1                          1 (20.0%)         0              0       
+      3                              0         1 (33.3%)          0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>Note that missing baseline values are filtered out in the pre-processing step.</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="lbt13_cache/html/variant3_1fd8bceaf12a3d528860021c2f00fbc1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    adlb_f,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>  )</span>
+<span id="cb6-11"><a href="#cb6-11"></a></span>
+<span id="cb6-12"><a href="#cb6-12"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb6-13"><a href="#cb6-13"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a>  <span class="fu">filter</span>(BTOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span> <span class="co"># filter out missing baseline grade</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb6-19"><a href="#cb6-19"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb6-20"><a href="#cb6-20"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>    )</span>
+<span id="cb6-24"><a href="#cb6-24"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb6-29"><a href="#cb6-29"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>    )</span>
+<span id="cb6-33"><a href="#cb6-33"></a>  )</span>
+<span id="cb6-34"><a href="#cb6-34"></a></span>
+<span id="cb6-35"><a href="#cb6-35"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb6-36"><a href="#cb6-36"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb6-39"><a href="#cb6-39"></a>)</span>
+<span id="cb6-40"><a href="#cb6-40"></a></span>
+<span id="cb6-41"><a href="#cb6-41"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb6-43"><a href="#cb6-43"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb6-47"><a href="#cb6-47"></a>  )</span>
+<span id="cb6-48"><a href="#cb6-48"></a></span>
+<span id="cb6-49"><a href="#cb6-49"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-51"><a href="#cb6-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-52"><a href="#cb6-52"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb6-53"><a href="#cb6-53"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb6-54"><a href="#cb6-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-55"><a href="#cb6-55"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-56"><a href="#cb6-56"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb6-57"><a href="#cb6-57"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb6-58"><a href="#cb6-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-60"><a href="#cb6-60"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb6-61"><a href="#cb6-61"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb6-62"><a href="#cb6-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-63"><a href="#cb6-63"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-64"><a href="#cb6-64"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-65"><a href="#cb6-65"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb6-66"><a href="#cb6-66"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb6-67"><a href="#cb6-67"></a></span>
+<span id="cb6-68"><a href="#cb6-68"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                             
+  Visit                                                                    
+    NCI CTCAE Grade at Visit      A: Drug X    B: Placebo    C: Combination
+      Baseline NCI CTCAE Grade     (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————
+CRP                                                                        
+  WEEK 1 DAY 8                                                             
+    Not Low (n)                      116           110            101      
+      Not Low                    103 (88.8%)   91 (82.7%)      88 (87.1%)  
+      1                           3 (2.6%)      5 (4.5%)        6 (5.9%)   
+      2                           4 (3.4%)      9 (8.2%)        2 (2.0%)   
+      3                           3 (2.6%)      4 (3.6%)        4 (4.0%)   
+      4                           3 (2.6%)      1 (0.9%)        1 (1.0%)   
+    1 (n)                             4             7              5       
+      Not Low                     3 (75.0%)     7 (100%)       4 (80.0%)   
+      3                           1 (25.0%)         0          1 (20.0%)   
+    2 (n)                             5             6              11      
+      Not Low                     5 (100%)      5 (83.3%)      8 (72.7%)   
+      1                               0             0           1 (9.1%)   
+      3                               0             0          2 (18.2%)   
+      4                               0         1 (16.7%)          0       
+    3 (n)                             6             8              5       
+      Not Low                     6 (100%)      7 (87.5%)       5 (100%)   
+      3                               0         1 (12.5%)          0       
+    4 (n)                             3             3              10      
+      Not Low                     2 (66.7%)     3 (100%)       7 (70.0%)   
+      1                               0             0          2 (20.0%)   
+      2                           1 (33.3%)         0              0       
+      4                               0             0          1 (10.0%)   
+  WEEK 2 DAY 15                                                            
+    Not Low (n)                      106           111            116      
+      Not Low                    93 (87.7%)    93 (83.8%)     100 (86.2%)  
+      1                           3 (2.8%)      4 (3.6%)        8 (6.9%)   
+      2                           5 (4.7%)      7 (6.3%)        2 (1.7%)   
+      3                           2 (1.9%)      5 (4.5%)        6 (5.2%)   
+      4                           3 (2.8%)      2 (1.8%)           0       
+    1 (n)                            15             9              2       
+      Not Low                    13 (86.7%)     8 (88.9%)      1 (50.0%)   
+      2                               0         1 (11.1%)          0       
+      3                           2 (13.3%)         0              0       
+      4                               0             0          1 (50.0%)   
+    2 (n)                             3             3              6       
+      Not Low                     3 (100%)      3 (100%)       4 (66.7%)   
+      1                               0             0          1 (16.7%)   
+      3                               0             0          1 (16.7%)   
+    3 (n)                             7             7              6       
+      Not Low                     7 (100%)      6 (85.7%)      5 (83.3%)   
+      2                               0         1 (14.3%)          0       
+      4                               0             0          1 (16.7%)   
+    4 (n)                             3             4              2       
+      Not Low                     3 (100%)      3 (75.0%)       2 (100%)   
+      1                               0         1 (25.0%)          0       
+  WEEK 3 DAY 22                                                            
+    Not Low (n)                      119           110            114      
+      Not Low                    104 (87.4%)   92 (83.6%)      94 (82.5%)  
+      1                           3 (2.5%)      4 (3.6%)        9 (7.9%)   
+      2                           5 (4.2%)      7 (6.4%)        2 (1.8%)   
+      3                           4 (3.4%)      5 (4.5%)        7 (6.1%)   
+      4                           3 (2.5%)      2 (1.8%)        2 (1.8%)   
+    1 (n)                             9             9              6       
+      Not Low                     9 (100%)      7 (77.8%)       6 (100%)   
+      2                               0         2 (22.2%)          0       
+    2 (n)                             1             7              3       
+      Not Low                     1 (100%)      6 (85.7%)       3 (100%)   
+      1                               0         1 (14.3%)          0       
+    3 (n)                             4             5              4       
+      Not Low                     4 (100%)      5 (100%)        4 (100%)   
+    4 (n)                             1             3              5       
+      Not Low                     1 (100%)      3 (100%)        5 (100%)   
+  WEEK 4 DAY 29                                                            
+    Not Low (n)                      101           119            111      
+      Not Low                    89 (88.1%)    100 (84.0%)     96 (86.5%)  
+      1                           3 (3.0%)      4 (3.4%)        6 (5.4%)   
+      2                           4 (4.0%)      8 (6.7%)        1 (0.9%)   
+      3                           2 (2.0%)      5 (4.2%)        6 (5.4%)   
+      4                           3 (3.0%)      2 (1.7%)        2 (1.8%)   
+    1 (n)                            10             5              6       
+      Not Low                     9 (90.0%)     5 (100%)       5 (83.3%)   
+      1                               0             0          1 (16.7%)   
+      2                           1 (10.0%)         0              0       
+    2 (n)                            13             4              6       
+      Not Low                     13 (100%)     3 (75.0%)      5 (83.3%)   
+      1                               0             0          1 (16.7%)   
+      2                               0         1 (25.0%)          0       
+    3 (n)                             8             2              6       
+      Not Low                     6 (75.0%)     1 (50.0%)      5 (83.3%)   
+      1                               0         1 (50.0%)          0       
+      2                               0             0          1 (16.7%)   
+      3                           2 (25.0%)         0              0       
+    4 (n)                             2             4              3       
+      Not Low                     2 (100%)      4 (100%)       1 (33.3%)   
+      1                               0             0          1 (33.3%)   
+      3                               0             0          1 (33.3%)   
+  WEEK 5 DAY 36                                                            
+    Not Low (n)                      115           112            111      
+      Not Low                    102 (88.7%)   94 (83.9%)      96 (86.5%)  
+      1                           2 (1.7%)      4 (3.6%)        6 (5.4%)   
+      2                           5 (4.3%)      7 (6.2%)        2 (1.8%)   
+      3                           3 (2.6%)      5 (4.5%)        5 (4.5%)   
+      4                           3 (2.6%)      2 (1.8%)        2 (1.8%)   
+    1 (n)                             5             7              6       
+      Not Low                     5 (100%)      4 (57.1%)      5 (83.3%)   
+      1                               0         1 (14.3%)      1 (16.7%)   
+      2                               0         2 (28.6%)          0       
+    2 (n)                             5            11              6       
+      Not Low                     5 (100%)      11 (100%)       6 (100%)   
+    3 (n)                             8             2              7       
+      Not Low                     6 (75.0%)     2 (100%)       4 (57.1%)   
+      1                           1 (12.5%)         0          1 (14.3%)   
+      3                           1 (12.5%)         0          2 (28.6%)   
+    4 (n)                             1             2              2       
+      Not Low                     1 (100%)      2 (100%)       1 (50.0%)   
+      1                               0             0          1 (50.0%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Note that when <code>BTOXGR</code> is missing, the grouping variable <code>BTOXGR_GP</code> is now <code>"Not High"</code> instead of <code>"Missing"</code> compared to <em>Standard Table (High)</em>.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="lbt13_cache/html/variant4_f07b87c4753bf68290b564867bb99e6b">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    adlb_f,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  )</span>
+<span id="cb8-11"><a href="#cb8-11"></a></span>
+<span id="cb8-12"><a href="#cb8-12"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-16"><a href="#cb8-16"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb8-18"><a href="#cb8-18"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb8-21"><a href="#cb8-21"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>    )</span>
+<span id="cb8-23"><a href="#cb8-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-25"><a href="#cb8-25"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb8-26"><a href="#cb8-26"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>, <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">~</span> <span class="st">"Not High"</span>, <span class="co"># Missing BTOXGR now grouped to "Not High"</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb8-28"><a href="#cb8-28"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb8-29"><a href="#cb8-29"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb8-30"><a href="#cb8-30"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>    )</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  )</span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb8-37"><a href="#cb8-37"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb8-38"><a href="#cb8-38"></a>)</span>
+<span id="cb8-39"><a href="#cb8-39"></a></span>
+<span id="cb8-40"><a href="#cb8-40"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  )</span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-49"><a href="#cb8-49"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-51"><a href="#cb8-51"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb8-53"><a href="#cb8-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-55"><a href="#cb8-55"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb8-57"><a href="#cb8-57"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-59"><a href="#cb8-59"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb8-60"><a href="#cb8-60"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb8-61"><a href="#cb8-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-62"><a href="#cb8-62"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-65"><a href="#cb8-65"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                            
+  Visit                                                                   
+    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination
+      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————
+CRP                                                                       
+  WEEK 1 DAY 8                                                            
+    Not High (n)                    111           110            112      
+      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  
+      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   
+      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   
+      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   
+      4                           2 (1.8%)     2 (1.8%)           0       
+    1 (n)                            8            11              6       
+      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   
+      3                          1 (12.5%)         0          1 (16.7%)   
+    2 (n)                            6             4              5       
+      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   
+      1                              0         3 (75.0%)      1 (20.0%)   
+    3 (n)                            8             3              4       
+      Not High                   7 (87.5%)     3 (100%)        4 (100%)   
+      4                          1 (12.5%)         0              0       
+    4 (n)                            1             6              5       
+      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   
+      1                              0             0          1 (20.0%)   
+      3                              0         1 (16.7%)          0       
+  WEEK 2 DAY 15                                                           
+    Not High (n)                    117           113            113      
+      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  
+      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   
+      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   
+      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   
+      4                           3 (2.6%)     2 (1.8%)           0       
+    1 (n)                            6             9              7       
+      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   
+      1                              0         1 (11.1%)          0       
+      2                              0             0          1 (14.3%)   
+      3                          1 (16.7%)         0              0       
+    2 (n)                            4             4              6       
+      Not High                    4 (100%)     4 (100%)       3 (50.0%)   
+      1                              0             0          3 (50.0%)   
+    3 (n)                            5             3              5       
+      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   
+      1                          1 (20.0%)     1 (33.3%)          0       
+    4 (n)                            2             5              1       
+      Not High                    2 (100%)     3 (60.0%)       1 (100%)   
+      1                              0         2 (40.0%)          0       
+  WEEK 3 DAY 22                                                           
+    Not High (n)                    110           111            114      
+      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  
+      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   
+      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   
+      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+    1 (n)                            7             8              7       
+      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   
+      1                              0         1 (12.5%)          0       
+      2                              0         1 (12.5%)      1 (14.3%)   
+      3                              0         1 (12.5%)          0       
+    2 (n)                            9             7              5       
+      Not High                    9 (100%)     6 (85.7%)       5 (100%)   
+      3                              0         1 (14.3%)          0       
+    3 (n)                            6             3              4       
+      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   
+      3                          1 (16.7%)         0              0       
+      4                              0         1 (33.3%)          0       
+    4 (n)                            2             5              2       
+      Not High                   1 (50.0%)     5 (100%)        2 (100%)   
+      3                          1 (50.0%)         0              0       
+  WEEK 4 DAY 29                                                           
+    Not High (n)                    115           117            113      
+      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  
+      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   
+      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   
+      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   
+      4                           1 (0.9%)         0              0       
+    1 (n)                            4             3              11      
+      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  
+      2                              0             0           1 (9.1%)   
+      4                              0         1 (33.3%)          0       
+    2 (n)                            6             4              2       
+      Not High                    6 (100%)     3 (75.0%)       2 (100%)   
+      1                              0         1 (25.0%)          0       
+    3 (n)                            6             7              4       
+      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   
+      1                              0         1 (14.3%)          0       
+      3                              0         1 (14.3%)          0       
+      4                          1 (16.7%)     1 (14.3%)          0       
+    4 (n)                            3             3              2       
+      Not High                   2 (66.7%)     2 (66.7%)          0       
+      1                              0         1 (33.3%)      1 (50.0%)   
+      2                              0             0          1 (50.0%)   
+      4                          1 (33.3%)         0              0       
+  WEEK 5 DAY 36                                                           
+    Not High (n)                    111           111            119      
+      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  
+      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   
+      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   
+      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+    1 (n)                            8            11              5       
+      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   
+      1                              0         1 (9.1%)           0       
+      2                              0             0          1 (20.0%)   
+      3                          1 (12.5%)     1 (9.1%)           0       
+    2 (n)                            7             6              3       
+      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   
+      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   
+      2                          1 (14.3%)     1 (16.7%)          0       
+      4                              0         1 (16.7%)          0       
+    3 (n)                            3             3              4       
+      Not High                    3 (100%)     3 (100%)        4 (100%)   
+    4 (n)                            5             3              1       
+      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   
+      1                          1 (20.0%)         0              0       
+      3                              0         1 (33.3%)          0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Pre-processing is the same as for <em>Standard Table (High)</em>, but in order to keep all levels, the <code>drop</code> argument in <code>count_occurrences</code> is set to <code>FALSE</code>.</p>
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="lbt13_cache/html/variant5_3a144b61b9551318ec3701ab63fef652">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb10-6"><a href="#cb10-6"></a>    adlb_f,</span>
+<span id="cb10-7"><a href="#cb10-7"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb10-8"><a href="#cb10-8"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-9"><a href="#cb10-9"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  )</span>
+<span id="cb10-11"><a href="#cb10-11"></a></span>
+<span id="cb10-12"><a href="#cb10-12"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb10-13"><a href="#cb10-13"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-16"><a href="#cb10-16"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb10-17"><a href="#cb10-17"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb10-18"><a href="#cb10-18"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb10-19"><a href="#cb10-19"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb10-20"><a href="#cb10-20"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb10-22"><a href="#cb10-22"></a>    )</span>
+<span id="cb10-23"><a href="#cb10-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-25"><a href="#cb10-25"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb10-26"><a href="#cb10-26"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb10-27"><a href="#cb10-27"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb10-28"><a href="#cb10-28"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb10-29"><a href="#cb10-29"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb10-30"><a href="#cb10-30"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>    )</span>
+<span id="cb10-33"><a href="#cb10-33"></a>  )</span>
+<span id="cb10-34"><a href="#cb10-34"></a></span>
+<span id="cb10-35"><a href="#cb10-35"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb10-36"><a href="#cb10-36"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb10-38"><a href="#cb10-38"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb10-39"><a href="#cb10-39"></a>)</span>
+<span id="cb10-40"><a href="#cb10-40"></a></span>
+<span id="cb10-41"><a href="#cb10-41"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb10-45"><a href="#cb10-45"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>  )</span>
+<span id="cb10-48"><a href="#cb10-48"></a></span>
+<span id="cb10-49"><a href="#cb10-49"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb10-53"><a href="#cb10-53"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-56"><a href="#cb10-56"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb10-57"><a href="#cb10-57"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb10-58"><a href="#cb10-58"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb10-64"><a href="#cb10-64"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-65"><a href="#cb10-65"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb10-68"><a href="#cb10-68"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb10-69"><a href="#cb10-69"></a></span>
+<span id="cb10-70"><a href="#cb10-70"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter Code                                                            
+  Visit                                                                   
+    NCI CTCAE Grade at Visit     A: Drug X    B: Placebo    C: Combination
+      Baseline NCI CTCAE Grade    (N=134)       (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————
+CRP                                                                       
+  WEEK 1 DAY 8                                                            
+    Not High (n)                    111           110            112      
+      Not High                   93 (83.8%)   92 (83.6%)      98 (87.5%)  
+      1                           8 (7.2%)     7 (6.4%)        5 (4.5%)   
+      2                           2 (1.8%)     6 (5.5%)        7 (6.2%)   
+      3                           6 (5.4%)     3 (2.7%)        2 (1.8%)   
+      4                           2 (1.8%)     2 (1.8%)           0       
+      Missing                        0             0              0       
+    1 (n)                            8            11              6       
+      Not High                   7 (87.5%)     11 (100%)      5 (83.3%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                          1 (12.5%)         0          1 (16.7%)   
+      4                              0             0              0       
+      Missing                        0             0              0       
+    2 (n)                            6             4              5       
+      Not High                    6 (100%)     1 (25.0%)      4 (80.0%)   
+      1                              0         3 (75.0%)      1 (20.0%)   
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    3 (n)                            8             3              4       
+      Not High                   7 (87.5%)     3 (100%)        4 (100%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                          1 (12.5%)         0              0       
+      Missing                        0             0              0       
+    4 (n)                            1             6              5       
+      Not High                    1 (100%)     5 (83.3%)      4 (80.0%)   
+      1                              0             0          1 (20.0%)   
+      2                              0             0              0       
+      3                              0         1 (16.7%)          0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    Missing (n)                      0             0              0       
+      Not High                       0             0              0       
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+  WEEK 2 DAY 15                                                           
+    Not High (n)                    117           113            113      
+      Not High                   99 (84.6%)   95 (84.1%)     100 (88.5%)  
+      1                           7 (6.0%)     6 (5.3%)        4 (3.5%)   
+      2                           2 (1.7%)     6 (5.3%)        6 (5.3%)   
+      3                           6 (5.1%)     4 (3.5%)        3 (2.7%)   
+      4                           3 (2.6%)     2 (1.8%)           0       
+      Missing                        0             0              0       
+    1 (n)                            6             9              7       
+      Not High                   5 (83.3%)     8 (88.9%)      6 (85.7%)   
+      1                              0         1 (11.1%)          0       
+      2                              0             0          1 (14.3%)   
+      3                          1 (16.7%)         0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    2 (n)                            4             4              6       
+      Not High                    4 (100%)     4 (100%)       3 (50.0%)   
+      1                              0             0          3 (50.0%)   
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    3 (n)                            5             3              5       
+      Not High                   4 (80.0%)     2 (66.7%)       5 (100%)   
+      1                          1 (20.0%)     1 (33.3%)          0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    4 (n)                            2             5              1       
+      Not High                    2 (100%)     3 (60.0%)       1 (100%)   
+      1                              0         2 (40.0%)          0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    Missing (n)                      0             0              0       
+      Not High                       0             0              0       
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+  WEEK 3 DAY 22                                                           
+    Not High (n)                    110           111            114      
+      Not High                   92 (83.6%)   94 (84.7%)      98 (86.0%)  
+      1                           8 (7.3%)     9 (8.1%)        7 (6.1%)   
+      2                           2 (1.8%)     5 (4.5%)        6 (5.3%)   
+      3                           5 (4.5%)     2 (1.8%)        3 (2.6%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+      Missing                        0             0              0       
+    1 (n)                            7             8              7       
+      Not High                    7 (100%)     5 (62.5%)      6 (85.7%)   
+      1                              0         1 (12.5%)          0       
+      2                              0         1 (12.5%)      1 (14.3%)   
+      3                              0         1 (12.5%)          0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    2 (n)                            9             7              5       
+      Not High                    9 (100%)     6 (85.7%)       5 (100%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0         1 (14.3%)          0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    3 (n)                            6             3              4       
+      Not High                   5 (83.3%)     2 (66.7%)       4 (100%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                          1 (16.7%)         0              0       
+      4                              0         1 (33.3%)          0       
+      Missing                        0             0              0       
+    4 (n)                            2             5              2       
+      Not High                   1 (50.0%)     5 (100%)        2 (100%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                          1 (50.0%)         0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    Missing (n)                      0             0              0       
+      Not High                       0             0              0       
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+  WEEK 4 DAY 29                                                           
+    Not High (n)                    115           117            113      
+      Not High                   97 (84.3%)   101 (86.3%)     99 (87.6%)  
+      1                           8 (7.0%)     7 (6.0%)        6 (5.3%)   
+      2                           2 (1.7%)     6 (5.1%)        5 (4.4%)   
+      3                           7 (6.1%)     3 (2.6%)        3 (2.7%)   
+      4                           1 (0.9%)         0              0       
+      Missing                        0             0              0       
+    1 (n)                            4             3              11      
+      Not High                    4 (100%)     2 (66.7%)      10 (90.9%)  
+      1                              0             0              0       
+      2                              0             0           1 (9.1%)   
+      3                              0             0              0       
+      4                              0         1 (33.3%)          0       
+      Missing                        0             0              0       
+    2 (n)                            6             4              2       
+      Not High                    6 (100%)     3 (75.0%)       2 (100%)   
+      1                              0         1 (25.0%)          0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    3 (n)                            6             7              4       
+      Not High                   5 (83.3%)     4 (57.1%)       4 (100%)   
+      1                              0         1 (14.3%)          0       
+      2                              0             0              0       
+      3                              0         1 (14.3%)          0       
+      4                          1 (16.7%)     1 (14.3%)          0       
+      Missing                        0             0              0       
+    4 (n)                            3             3              2       
+      Not High                   2 (66.7%)     2 (66.7%)          0       
+      1                              0         1 (33.3%)      1 (50.0%)   
+      2                              0             0          1 (50.0%)   
+      3                              0             0              0       
+      4                          1 (33.3%)         0              0       
+      Missing                        0             0              0       
+    Missing (n)                      0             0              0       
+      Not High                       0             0              0       
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+  WEEK 5 DAY 36                                                           
+    Not High (n)                    111           111            119      
+      Not High                   95 (85.6%)   95 (85.6%)     104 (87.4%)  
+      1                           6 (5.4%)     8 (7.2%)        6 (5.0%)   
+      2                           1 (0.9%)     5 (4.5%)        6 (5.0%)   
+      3                           6 (5.4%)     2 (1.8%)        3 (2.5%)   
+      4                           3 (2.7%)     1 (0.9%)           0       
+      Missing                        0             0              0       
+    1 (n)                            8            11              5       
+      Not High                   7 (87.5%)     9 (81.8%)      4 (80.0%)   
+      1                              0         1 (9.1%)           0       
+      2                              0             0          1 (20.0%)   
+      3                          1 (12.5%)     1 (9.1%)           0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    2 (n)                            7             6              3       
+      Not High                   5 (71.4%)     3 (50.0%)      2 (66.7%)   
+      1                          1 (14.3%)     1 (16.7%)      1 (33.3%)   
+      2                          1 (14.3%)     1 (16.7%)          0       
+      3                              0             0              0       
+      4                              0         1 (16.7%)          0       
+      Missing                        0             0              0       
+    3 (n)                            3             3              4       
+      Not High                    3 (100%)     3 (100%)        4 (100%)   
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    4 (n)                            5             3              1       
+      Not High                   4 (80.0%)     2 (66.7%)       1 (100%)   
+      1                          1 (20.0%)         0              0       
+      2                              0             0              0       
+      3                              0         1 (33.3%)          0       
+      4                              0             0              0       
+      Missing                        0             0              0       
+    Missing (n)                      0             0              0       
+      Not High                       0             0              0       
+      1                              0             0              0       
+      2                              0             0              0       
+      3                              0             0              0       
+      4                              0             0              0       
+      Missing                        0             0              0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:30}" data-hash="lbt13_cache/html/teal_43be2ab9bb2af0f97d7fac4b0fd2f551">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-4"><a href="#cb12-4"></a></span>
+<span id="cb12-5"><a href="#cb12-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-6"><a href="#cb12-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-10"><a href="#cb12-10"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-11"><a href="#cb12-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb12-12"><a href="#cb12-12"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb12-13"><a href="#cb12-13"></a>    ),</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a>  ),</span>
+<span id="cb12-16"><a href="#cb12-16"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-17"><a href="#cb12-17"></a>    <span class="fu">tm_t_shift_by_grade</span>(</span>
+<span id="cb12-18"><a href="#cb12-18"></a>      <span class="at">label =</span> <span class="st">"Grade Laboratory Abnormality Table"</span>,</span>
+<span id="cb12-19"><a href="#cb12-19"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb12-20"><a href="#cb12-20"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-21"><a href="#cb12-21"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-22"><a href="#cb12-22"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-23"><a href="#cb12-23"></a>      ),</span>
+<span id="cb12-24"><a href="#cb12-24"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-25"><a href="#cb12-25"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-26"><a href="#cb12-26"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a>      ),</span>
+<span id="cb12-28"><a href="#cb12-28"></a>      <span class="at">worst_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-29"><a href="#cb12-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>, <span class="st">"WGRLOFL"</span>, <span class="st">"WGRHIVFL"</span>, <span class="st">"WGRHIFL"</span>)),</span>
+<span id="cb12-30"><a href="#cb12-30"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>)</span>
+<span id="cb12-31"><a href="#cb12-31"></a>      ),</span>
+<span id="cb12-32"><a href="#cb12-32"></a>      <span class="at">worst_flag_indicator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"WGRLOVFL"</span>),</span>
+<span id="cb12-34"><a href="#cb12-34"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>      ),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>      <span class="at">anl_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-37"><a href="#cb12-37"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>)),</span>
+<span id="cb12-38"><a href="#cb12-38"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>),</span>
+<span id="cb12-39"><a href="#cb12-39"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>      ),</span>
+<span id="cb12-41"><a href="#cb12-41"></a>      <span class="at">base_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-42"><a href="#cb12-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>)),</span>
+<span id="cb12-43"><a href="#cb12-43"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>),</span>
+<span id="cb12-44"><a href="#cb12-44"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>      ),</span>
+<span id="cb12-46"><a href="#cb12-46"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>    )</span>
+<span id="cb12-48"><a href="#cb12-48"></a>  ),</span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-51"><a href="#cb12-51"></a>  )</span>
+<span id="cb12-52"><a href="#cb12-52"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:26:32.4707 pid:12041 token:[] teal.modules.clinical Initializing tm_t_shift_by_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt13_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt13_cache/html/sessioninfo_e9017473f683a0914b084e169075b452">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt13_cache/html/snapshot_a9a2c3506837c23f2df07752e7e9dfb3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-2"><a href="#cb17-2"></a></span>
+<span id="cb17-3"><a href="#cb17-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb17-4"><a href="#cb17-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb17-5"><a href="#cb17-5"></a></span>
+<span id="cb17-6"><a href="#cb17-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb17-7"><a href="#cb17-7"></a></span>
+<span id="cb17-8"><a href="#cb17-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb17-10"><a href="#cb17-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt13.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/lab-results/lbt12_bl.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">LBT12_BL</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/lab-results/lbt14.html" class="pagination-link">
+        <span class="nav-page-text">LBT14</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb18" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb18-1"><a href="#cb18-1"></a><span class="co">---</span></span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="an">title:</span><span class="co"> LBT13</span></span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="an">subtitle:</span><span class="co"> NCI CTCAE Grade Laboratory Abnormalities by Visit and Baseline Grade</span></span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="co">---</span></span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>------------------------------------------------------------------------</span>
+<span id="cb18-7"><a href="#cb18-7"></a></span>
+<span id="cb18-8"><a href="#cb18-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb18-9"><a href="#cb18-9"></a></span>
+<span id="cb18-10"><a href="#cb18-10"></a>::: panel-tabset</span>
+<span id="cb18-11"><a href="#cb18-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb18-12"><a href="#cb18-12"></a></span>
+<span id="cb18-13"><a href="#cb18-13"></a>Please note that for each variant, the <span class="in">`adlb`</span> dataset needs to be filtered on correct flags like <span class="in">`WGRLOVFL`</span>, <span class="in">`WGRHIVFL`</span>, et al., otherwise the layout function will not return the correct counts.</span>
+<span id="cb18-14"><a href="#cb18-14"></a>There is an option to create a record for a lab test where no record is found at that visit.</span>
+<span id="cb18-15"><a href="#cb18-15"></a>If you specified <span class="in">`add_derived_type = "PHANTOM"`</span> &amp; <span class="in">`dtype_phantom_cond`</span>, you don't have to use the <span class="in">`h_adsl_adlb_merge_using_worst_flag`</span> function to preprocess your <span class="in">`adlb`</span> dataset.</span>
+<span id="cb18-16"><a href="#cb18-16"></a>Otherwise please follow the pre-processing steps below before applying the layout functions.</span>
+<span id="cb18-17"><a href="#cb18-17"></a></span>
+<span id="cb18-18"><a href="#cb18-18"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb18-19"><a href="#cb18-19"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb18-20"><a href="#cb18-20"></a></span>
+<span id="cb18-21"><a href="#cb18-21"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-22"><a href="#cb18-22"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-23"><a href="#cb18-23"></a><span class="fu">library</span>(tern)</span>
+<span id="cb18-24"><a href="#cb18-24"></a></span>
+<span id="cb18-25"><a href="#cb18-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-26"><a href="#cb18-26"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb18-27"><a href="#cb18-27"></a></span>
+<span id="cb18-28"><a href="#cb18-28"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb18-29"><a href="#cb18-29"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb18-30"><a href="#cb18-30"></a></span>
+<span id="cb18-31"><a href="#cb18-31"></a><span class="co"># Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be</span></span>
+<span id="cb18-32"><a href="#cb18-32"></a><span class="co"># selected properly.</span></span>
+<span id="cb18-33"><a href="#cb18-33"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-34"><a href="#cb18-34"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PARAMCD <span class="sc">==</span> <span class="st">"CRP"</span> <span class="sc">&amp;</span> SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-35"><a href="#cb18-35"></a><span class="in">```</span></span>
+<span id="cb18-36"><a href="#cb18-36"></a></span>
+<span id="cb18-37"><a href="#cb18-37"></a><span class="fu">## Standard Table (Low)</span></span>
+<span id="cb18-38"><a href="#cb18-38"></a></span>
+<span id="cb18-39"><a href="#cb18-39"></a>Note that the worst laboratory flag (below <span class="in">`WGRLOVFL`</span>) must be selected appropriately to match the direction of abnormality (here <span class="in">`Low`</span>).</span>
+<span id="cb18-40"><a href="#cb18-40"></a>New grouping variables <span class="in">`ATOXGR_GP`</span> and <span class="in">`BTOXGR_GP`</span> are created to display the correct output.</span>
+<span id="cb18-41"><a href="#cb18-41"></a></span>
+<span id="cb18-42"><a href="#cb18-42"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb18-43"><a href="#cb18-43"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-44"><a href="#cb18-44"></a></span>
+<span id="cb18-45"><a href="#cb18-45"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-46"><a href="#cb18-46"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb18-47"><a href="#cb18-47"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb18-48"><a href="#cb18-48"></a>    adlb_f,</span>
+<span id="cb18-49"><a href="#cb18-49"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb18-50"><a href="#cb18-50"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-51"><a href="#cb18-51"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb18-52"><a href="#cb18-52"></a>  )</span>
+<span id="cb18-53"><a href="#cb18-53"></a></span>
+<span id="cb18-54"><a href="#cb18-54"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-55"><a href="#cb18-55"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-56"><a href="#cb18-56"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-57"><a href="#cb18-57"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-58"><a href="#cb18-58"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-59"><a href="#cb18-59"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-60"><a href="#cb18-60"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-61"><a href="#cb18-61"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-62"><a href="#cb18-62"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-63"><a href="#cb18-63"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-64"><a href="#cb18-64"></a>    )</span>
+<span id="cb18-65"><a href="#cb18-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-66"><a href="#cb18-66"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-67"><a href="#cb18-67"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-68"><a href="#cb18-68"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-69"><a href="#cb18-69"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-70"><a href="#cb18-70"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-71"><a href="#cb18-71"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-72"><a href="#cb18-72"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-73"><a href="#cb18-73"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-74"><a href="#cb18-74"></a>    )</span>
+<span id="cb18-75"><a href="#cb18-75"></a>  )</span>
+<span id="cb18-76"><a href="#cb18-76"></a></span>
+<span id="cb18-77"><a href="#cb18-77"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb18-78"><a href="#cb18-78"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb18-79"><a href="#cb18-79"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-80"><a href="#cb18-80"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-81"><a href="#cb18-81"></a>)</span>
+<span id="cb18-82"><a href="#cb18-82"></a></span>
+<span id="cb18-83"><a href="#cb18-83"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-84"><a href="#cb18-84"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-85"><a href="#cb18-85"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb18-86"><a href="#cb18-86"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb18-87"><a href="#cb18-87"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb18-88"><a href="#cb18-88"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb18-89"><a href="#cb18-89"></a>  )</span>
+<span id="cb18-90"><a href="#cb18-90"></a></span>
+<span id="cb18-91"><a href="#cb18-91"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-92"><a href="#cb18-92"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-93"><a href="#cb18-93"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-94"><a href="#cb18-94"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb18-95"><a href="#cb18-95"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb18-96"><a href="#cb18-96"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-97"><a href="#cb18-97"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-98"><a href="#cb18-98"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb18-99"><a href="#cb18-99"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb18-100"><a href="#cb18-100"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-101"><a href="#cb18-101"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-102"><a href="#cb18-102"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb18-103"><a href="#cb18-103"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb18-104"><a href="#cb18-104"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-105"><a href="#cb18-105"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb18-106"><a href="#cb18-106"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-107"><a href="#cb18-107"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-108"><a href="#cb18-108"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-109"><a href="#cb18-109"></a></span>
+<span id="cb18-110"><a href="#cb18-110"></a>result</span>
+<span id="cb18-111"><a href="#cb18-111"></a><span class="in">```</span></span>
+<span id="cb18-112"><a href="#cb18-112"></a></span>
+<span id="cb18-113"><a href="#cb18-113"></a><span class="fu">## Standard Table (High)</span></span>
+<span id="cb18-114"><a href="#cb18-114"></a></span>
+<span id="cb18-115"><a href="#cb18-115"></a>Note that the worst laboratory flag (below <span class="in">`WGRHIVFL`</span>) must be selected appropriately to match the direction of abnormality (here <span class="in">`High`</span>).</span>
+<span id="cb18-116"><a href="#cb18-116"></a>New grouping variables <span class="in">`ATOXGR_GP`</span> and <span class="in">`BTOXGR_GP`</span> are created to display the correct output.</span>
+<span id="cb18-117"><a href="#cb18-117"></a></span>
+<span id="cb18-118"><a href="#cb18-118"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb18-119"><a href="#cb18-119"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-120"><a href="#cb18-120"></a></span>
+<span id="cb18-121"><a href="#cb18-121"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-122"><a href="#cb18-122"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb18-123"><a href="#cb18-123"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb18-124"><a href="#cb18-124"></a>    adlb_f,</span>
+<span id="cb18-125"><a href="#cb18-125"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb18-126"><a href="#cb18-126"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-127"><a href="#cb18-127"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb18-128"><a href="#cb18-128"></a>  )</span>
+<span id="cb18-129"><a href="#cb18-129"></a></span>
+<span id="cb18-130"><a href="#cb18-130"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-131"><a href="#cb18-131"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-132"><a href="#cb18-132"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-133"><a href="#cb18-133"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-134"><a href="#cb18-134"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-135"><a href="#cb18-135"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-136"><a href="#cb18-136"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-137"><a href="#cb18-137"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-138"><a href="#cb18-138"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-139"><a href="#cb18-139"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-140"><a href="#cb18-140"></a>    )</span>
+<span id="cb18-141"><a href="#cb18-141"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-142"><a href="#cb18-142"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-143"><a href="#cb18-143"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-144"><a href="#cb18-144"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-145"><a href="#cb18-145"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-146"><a href="#cb18-146"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-147"><a href="#cb18-147"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-148"><a href="#cb18-148"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-149"><a href="#cb18-149"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-150"><a href="#cb18-150"></a>    )</span>
+<span id="cb18-151"><a href="#cb18-151"></a>  )</span>
+<span id="cb18-152"><a href="#cb18-152"></a></span>
+<span id="cb18-153"><a href="#cb18-153"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb18-154"><a href="#cb18-154"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb18-155"><a href="#cb18-155"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-156"><a href="#cb18-156"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-157"><a href="#cb18-157"></a>)</span>
+<span id="cb18-158"><a href="#cb18-158"></a></span>
+<span id="cb18-159"><a href="#cb18-159"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-160"><a href="#cb18-160"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-161"><a href="#cb18-161"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb18-162"><a href="#cb18-162"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb18-163"><a href="#cb18-163"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb18-164"><a href="#cb18-164"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb18-165"><a href="#cb18-165"></a>  )</span>
+<span id="cb18-166"><a href="#cb18-166"></a></span>
+<span id="cb18-167"><a href="#cb18-167"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-168"><a href="#cb18-168"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-169"><a href="#cb18-169"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-170"><a href="#cb18-170"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb18-171"><a href="#cb18-171"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb18-172"><a href="#cb18-172"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-173"><a href="#cb18-173"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-174"><a href="#cb18-174"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb18-175"><a href="#cb18-175"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb18-176"><a href="#cb18-176"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-177"><a href="#cb18-177"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-178"><a href="#cb18-178"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb18-179"><a href="#cb18-179"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb18-180"><a href="#cb18-180"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-181"><a href="#cb18-181"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb18-182"><a href="#cb18-182"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-183"><a href="#cb18-183"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-184"><a href="#cb18-184"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-185"><a href="#cb18-185"></a></span>
+<span id="cb18-186"><a href="#cb18-186"></a>result</span>
+<span id="cb18-187"><a href="#cb18-187"></a><span class="in">```</span></span>
+<span id="cb18-188"><a href="#cb18-188"></a></span>
+<span id="cb18-189"><a href="#cb18-189"></a><span class="fu">## Table Without Patients with &lt;br/&gt; Missing Baseline (Low)</span></span>
+<span id="cb18-190"><a href="#cb18-190"></a></span>
+<span id="cb18-191"><a href="#cb18-191"></a>Note that missing baseline values are filtered out in the pre-processing step.</span>
+<span id="cb18-192"><a href="#cb18-192"></a></span>
+<span id="cb18-193"><a href="#cb18-193"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb18-194"><a href="#cb18-194"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-195"><a href="#cb18-195"></a></span>
+<span id="cb18-196"><a href="#cb18-196"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-197"><a href="#cb18-197"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb18-198"><a href="#cb18-198"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb18-199"><a href="#cb18-199"></a>    adlb_f,</span>
+<span id="cb18-200"><a href="#cb18-200"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb18-201"><a href="#cb18-201"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-202"><a href="#cb18-202"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb18-203"><a href="#cb18-203"></a>  )</span>
+<span id="cb18-204"><a href="#cb18-204"></a></span>
+<span id="cb18-205"><a href="#cb18-205"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-206"><a href="#cb18-206"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-207"><a href="#cb18-207"></a>  <span class="fu">filter</span>(BTOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span> <span class="co"># filter out missing baseline grade</span></span>
+<span id="cb18-208"><a href="#cb18-208"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-209"><a href="#cb18-209"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-210"><a href="#cb18-210"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-211"><a href="#cb18-211"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-212"><a href="#cb18-212"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-213"><a href="#cb18-213"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-214"><a href="#cb18-214"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-215"><a href="#cb18-215"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-216"><a href="#cb18-216"></a>    )</span>
+<span id="cb18-217"><a href="#cb18-217"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-218"><a href="#cb18-218"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-219"><a href="#cb18-219"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-220"><a href="#cb18-220"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-221"><a href="#cb18-221"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-222"><a href="#cb18-222"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-223"><a href="#cb18-223"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-224"><a href="#cb18-224"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb18-225"><a href="#cb18-225"></a>    )</span>
+<span id="cb18-226"><a href="#cb18-226"></a>  )</span>
+<span id="cb18-227"><a href="#cb18-227"></a></span>
+<span id="cb18-228"><a href="#cb18-228"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb18-229"><a href="#cb18-229"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb18-230"><a href="#cb18-230"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-231"><a href="#cb18-231"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb18-232"><a href="#cb18-232"></a>)</span>
+<span id="cb18-233"><a href="#cb18-233"></a></span>
+<span id="cb18-234"><a href="#cb18-234"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-235"><a href="#cb18-235"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-236"><a href="#cb18-236"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb18-237"><a href="#cb18-237"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb18-238"><a href="#cb18-238"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb18-239"><a href="#cb18-239"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb18-240"><a href="#cb18-240"></a>  )</span>
+<span id="cb18-241"><a href="#cb18-241"></a></span>
+<span id="cb18-242"><a href="#cb18-242"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-243"><a href="#cb18-243"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-244"><a href="#cb18-244"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-245"><a href="#cb18-245"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb18-246"><a href="#cb18-246"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb18-247"><a href="#cb18-247"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-248"><a href="#cb18-248"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-249"><a href="#cb18-249"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb18-250"><a href="#cb18-250"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb18-251"><a href="#cb18-251"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-252"><a href="#cb18-252"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-253"><a href="#cb18-253"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb18-254"><a href="#cb18-254"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb18-255"><a href="#cb18-255"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-256"><a href="#cb18-256"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb18-257"><a href="#cb18-257"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-258"><a href="#cb18-258"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-259"><a href="#cb18-259"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-260"><a href="#cb18-260"></a></span>
+<span id="cb18-261"><a href="#cb18-261"></a>result</span>
+<span id="cb18-262"><a href="#cb18-262"></a><span class="in">```</span></span>
+<span id="cb18-263"><a href="#cb18-263"></a></span>
+<span id="cb18-264"><a href="#cb18-264"></a><span class="fu">## Table with Missing Baseline &lt;br/&gt; Considered as Grade 0 (High)</span></span>
+<span id="cb18-265"><a href="#cb18-265"></a></span>
+<span id="cb18-266"><a href="#cb18-266"></a>Note that when <span class="in">`BTOXGR`</span> is missing, the grouping variable <span class="in">`BTOXGR_GP`</span> is now <span class="in">`"Not High"`</span> instead of <span class="in">`"Missing"`</span> compared to *Standard Table (High)*.</span>
+<span id="cb18-267"><a href="#cb18-267"></a></span>
+<span id="cb18-268"><a href="#cb18-268"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb18-269"><a href="#cb18-269"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-270"><a href="#cb18-270"></a></span>
+<span id="cb18-271"><a href="#cb18-271"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-272"><a href="#cb18-272"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb18-273"><a href="#cb18-273"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb18-274"><a href="#cb18-274"></a>    adlb_f,</span>
+<span id="cb18-275"><a href="#cb18-275"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb18-276"><a href="#cb18-276"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-277"><a href="#cb18-277"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb18-278"><a href="#cb18-278"></a>  )</span>
+<span id="cb18-279"><a href="#cb18-279"></a></span>
+<span id="cb18-280"><a href="#cb18-280"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-281"><a href="#cb18-281"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-282"><a href="#cb18-282"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-283"><a href="#cb18-283"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-284"><a href="#cb18-284"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-285"><a href="#cb18-285"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-286"><a href="#cb18-286"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-287"><a href="#cb18-287"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-288"><a href="#cb18-288"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-289"><a href="#cb18-289"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-290"><a href="#cb18-290"></a>    )</span>
+<span id="cb18-291"><a href="#cb18-291"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-292"><a href="#cb18-292"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-293"><a href="#cb18-293"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-294"><a href="#cb18-294"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>, <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">~</span> <span class="st">"Not High"</span>, <span class="co"># Missing BTOXGR now grouped to "Not High"</span></span>
+<span id="cb18-295"><a href="#cb18-295"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-296"><a href="#cb18-296"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-297"><a href="#cb18-297"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-298"><a href="#cb18-298"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb18-299"><a href="#cb18-299"></a>    )</span>
+<span id="cb18-300"><a href="#cb18-300"></a>  )</span>
+<span id="cb18-301"><a href="#cb18-301"></a></span>
+<span id="cb18-302"><a href="#cb18-302"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb18-303"><a href="#cb18-303"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb18-304"><a href="#cb18-304"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-305"><a href="#cb18-305"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-306"><a href="#cb18-306"></a>)</span>
+<span id="cb18-307"><a href="#cb18-307"></a></span>
+<span id="cb18-308"><a href="#cb18-308"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-309"><a href="#cb18-309"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-310"><a href="#cb18-310"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb18-311"><a href="#cb18-311"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb18-312"><a href="#cb18-312"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb18-313"><a href="#cb18-313"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb18-314"><a href="#cb18-314"></a>  )</span>
+<span id="cb18-315"><a href="#cb18-315"></a></span>
+<span id="cb18-316"><a href="#cb18-316"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-317"><a href="#cb18-317"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-318"><a href="#cb18-318"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-319"><a href="#cb18-319"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb18-320"><a href="#cb18-320"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb18-321"><a href="#cb18-321"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-322"><a href="#cb18-322"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-323"><a href="#cb18-323"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb18-324"><a href="#cb18-324"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb18-325"><a href="#cb18-325"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-326"><a href="#cb18-326"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-327"><a href="#cb18-327"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb18-328"><a href="#cb18-328"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb18-329"><a href="#cb18-329"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-330"><a href="#cb18-330"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb18-331"><a href="#cb18-331"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-332"><a href="#cb18-332"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-333"><a href="#cb18-333"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-334"><a href="#cb18-334"></a></span>
+<span id="cb18-335"><a href="#cb18-335"></a>result</span>
+<span id="cb18-336"><a href="#cb18-336"></a><span class="in">```</span></span>
+<span id="cb18-337"><a href="#cb18-337"></a></span>
+<span id="cb18-338"><a href="#cb18-338"></a><span class="fu">## Table with Fill-In &lt;br/&gt; of Grades (High)</span></span>
+<span id="cb18-339"><a href="#cb18-339"></a></span>
+<span id="cb18-340"><a href="#cb18-340"></a>Pre-processing is the same as for *Standard Table (High)*, but in order to keep all levels, the <span class="in">`drop`</span> argument in <span class="in">`count_occurrences`</span> is set to <span class="in">`FALSE`</span>.</span>
+<span id="cb18-341"><a href="#cb18-341"></a></span>
+<span id="cb18-342"><a href="#cb18-342"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb18-343"><a href="#cb18-343"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIVFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-344"><a href="#cb18-344"></a></span>
+<span id="cb18-345"><a href="#cb18-345"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-346"><a href="#cb18-346"></a>adlb_out <span class="ot">&lt;-</span> adsl_f <span class="sc">%&gt;%</span></span>
+<span id="cb18-347"><a href="#cb18-347"></a>  <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(</span>
+<span id="cb18-348"><a href="#cb18-348"></a>    adlb_f,</span>
+<span id="cb18-349"><a href="#cb18-349"></a>    <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIVFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>),</span>
+<span id="cb18-350"><a href="#cb18-350"></a>    <span class="at">by_visit =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb18-351"><a href="#cb18-351"></a>    <span class="at">no_fillin_visits =</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>, <span class="st">"UNSCHEDULED"</span>)</span>
+<span id="cb18-352"><a href="#cb18-352"></a>  )</span>
+<span id="cb18-353"><a href="#cb18-353"></a></span>
+<span id="cb18-354"><a href="#cb18-354"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-355"><a href="#cb18-355"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-356"><a href="#cb18-356"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-357"><a href="#cb18-357"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-358"><a href="#cb18-358"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-359"><a href="#cb18-359"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-360"><a href="#cb18-360"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-361"><a href="#cb18-361"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-362"><a href="#cb18-362"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-363"><a href="#cb18-363"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-364"><a href="#cb18-364"></a>    )</span>
+<span id="cb18-365"><a href="#cb18-365"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-366"><a href="#cb18-366"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-367"><a href="#cb18-367"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">case_when</span>(</span>
+<span id="cb18-368"><a href="#cb18-368"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-369"><a href="#cb18-369"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-370"><a href="#cb18-370"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-371"><a href="#cb18-371"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-372"><a href="#cb18-372"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-373"><a href="#cb18-373"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-374"><a href="#cb18-374"></a>    )</span>
+<span id="cb18-375"><a href="#cb18-375"></a>  )</span>
+<span id="cb18-376"><a href="#cb18-376"></a></span>
+<span id="cb18-377"><a href="#cb18-377"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span> <span class="fu">mutate</span>(</span>
+<span id="cb18-378"><a href="#cb18-378"></a>  <span class="at">AVISIT =</span> forcats<span class="sc">::</span><span class="fu">fct_reorder</span>(AVISIT, AVISITN),</span>
+<span id="cb18-379"><a href="#cb18-379"></a>  <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(ATOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-380"><a href="#cb18-380"></a>  <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(BTOXGR_GP, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-381"><a href="#cb18-381"></a>)</span>
+<span id="cb18-382"><a href="#cb18-382"></a></span>
+<span id="cb18-383"><a href="#cb18-383"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-384"><a href="#cb18-384"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb18-385"><a href="#cb18-385"></a>    <span class="at">PARAMCD =</span> <span class="st">"Parameter Code"</span>,</span>
+<span id="cb18-386"><a href="#cb18-386"></a>    <span class="at">AVISIT =</span> <span class="st">"Visit"</span>,</span>
+<span id="cb18-387"><a href="#cb18-387"></a>    <span class="at">ATOXGR_GP =</span> <span class="st">"NCI CTCAE Grade at Visit"</span>,</span>
+<span id="cb18-388"><a href="#cb18-388"></a>    <span class="at">BTOXGR_GP =</span> <span class="st">"Baseline NCI CTCAE Grade"</span></span>
+<span id="cb18-389"><a href="#cb18-389"></a>  )</span>
+<span id="cb18-390"><a href="#cb18-390"></a></span>
+<span id="cb18-391"><a href="#cb18-391"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-392"><a href="#cb18-392"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-393"><a href="#cb18-393"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-394"><a href="#cb18-394"></a>    <span class="st">"PARAMCD"</span>,</span>
+<span id="cb18-395"><a href="#cb18-395"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>PARAMCD)</span>
+<span id="cb18-396"><a href="#cb18-396"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-397"><a href="#cb18-397"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-398"><a href="#cb18-398"></a>    <span class="st">"AVISIT"</span>,</span>
+<span id="cb18-399"><a href="#cb18-399"></a>    <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>AVISIT)</span>
+<span id="cb18-400"><a href="#cb18-400"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-401"><a href="#cb18-401"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-402"><a href="#cb18-402"></a>    <span class="st">"ATOXGR_GP"</span>,</span>
+<span id="cb18-403"><a href="#cb18-403"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>)),</span>
+<span id="cb18-404"><a href="#cb18-404"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-405"><a href="#cb18-405"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb_out<span class="sc">$</span>ATOXGR_GP)</span>
+<span id="cb18-406"><a href="#cb18-406"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-407"><a href="#cb18-407"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb18-408"><a href="#cb18-408"></a>  <span class="fu">count_occurrences</span>(<span class="st">"BTOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-409"><a href="#cb18-409"></a>  <span class="fu">append_varlabels</span>(adlb_out, <span class="st">"BTOXGR_GP"</span>, <span class="at">indent =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-410"><a href="#cb18-410"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-411"><a href="#cb18-411"></a></span>
+<span id="cb18-412"><a href="#cb18-412"></a>result</span>
+<span id="cb18-413"><a href="#cb18-413"></a><span class="in">```</span></span>
+<span id="cb18-414"><a href="#cb18-414"></a></span>
+<span id="cb18-415"><a href="#cb18-415"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb18-416"><a href="#cb18-416"></a></span>
+<span id="cb18-417"><a href="#cb18-417"></a><span class="fu">## `teal` App</span></span>
+<span id="cb18-418"><a href="#cb18-418"></a></span>
+<span id="cb18-419"><a href="#cb18-419"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb18-420"><a href="#cb18-420"></a><span class="co">#| screenshot.opts = list(delay = 30)</span></span>
+<span id="cb18-421"><a href="#cb18-421"></a></span>
+<span id="cb18-422"><a href="#cb18-422"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-423"><a href="#cb18-423"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-424"><a href="#cb18-424"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb18-425"><a href="#cb18-425"></a></span>
+<span id="cb18-426"><a href="#cb18-426"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-427"><a href="#cb18-427"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb18-428"><a href="#cb18-428"></a></span>
+<span id="cb18-429"><a href="#cb18-429"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb18-430"><a href="#cb18-430"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb18-431"><a href="#cb18-431"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb18-432"><a href="#cb18-432"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb18-433"><a href="#cb18-433"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb18-434"><a href="#cb18-434"></a>    ),</span>
+<span id="cb18-435"><a href="#cb18-435"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-436"><a href="#cb18-436"></a>  ),</span>
+<span id="cb18-437"><a href="#cb18-437"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb18-438"><a href="#cb18-438"></a>    <span class="fu">tm_t_shift_by_grade</span>(</span>
+<span id="cb18-439"><a href="#cb18-439"></a>      <span class="at">label =</span> <span class="st">"Grade Laboratory Abnormality Table"</span>,</span>
+<span id="cb18-440"><a href="#cb18-440"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb18-441"><a href="#cb18-441"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-442"><a href="#cb18-442"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb18-443"><a href="#cb18-443"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb18-444"><a href="#cb18-444"></a>      ),</span>
+<span id="cb18-445"><a href="#cb18-445"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-446"><a href="#cb18-446"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb18-447"><a href="#cb18-447"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb18-448"><a href="#cb18-448"></a>      ),</span>
+<span id="cb18-449"><a href="#cb18-449"></a>      <span class="at">worst_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-450"><a href="#cb18-450"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>, <span class="st">"WGRLOFL"</span>, <span class="st">"WGRHIVFL"</span>, <span class="st">"WGRHIFL"</span>)),</span>
+<span id="cb18-451"><a href="#cb18-451"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>)</span>
+<span id="cb18-452"><a href="#cb18-452"></a>      ),</span>
+<span id="cb18-453"><a href="#cb18-453"></a>      <span class="at">worst_flag_indicator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-454"><a href="#cb18-454"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"WGRLOVFL"</span>),</span>
+<span id="cb18-455"><a href="#cb18-455"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-456"><a href="#cb18-456"></a>      ),</span>
+<span id="cb18-457"><a href="#cb18-457"></a>      <span class="at">anl_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-458"><a href="#cb18-458"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>)),</span>
+<span id="cb18-459"><a href="#cb18-459"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>),</span>
+<span id="cb18-460"><a href="#cb18-460"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-461"><a href="#cb18-461"></a>      ),</span>
+<span id="cb18-462"><a href="#cb18-462"></a>      <span class="at">base_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-463"><a href="#cb18-463"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>)),</span>
+<span id="cb18-464"><a href="#cb18-464"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>),</span>
+<span id="cb18-465"><a href="#cb18-465"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-466"><a href="#cb18-466"></a>      ),</span>
+<span id="cb18-467"><a href="#cb18-467"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb18-468"><a href="#cb18-468"></a>    )</span>
+<span id="cb18-469"><a href="#cb18-469"></a>  ),</span>
+<span id="cb18-470"><a href="#cb18-470"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb18-471"><a href="#cb18-471"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-472"><a href="#cb18-472"></a>  )</span>
+<span id="cb18-473"><a href="#cb18-473"></a>)</span>
+<span id="cb18-474"><a href="#cb18-474"></a></span>
+<span id="cb18-475"><a href="#cb18-475"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb18-476"><a href="#cb18-476"></a><span class="in">```</span></span>
+<span id="cb18-477"><a href="#cb18-477"></a></span>
+<span id="cb18-478"><a href="#cb18-478"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb18-479"><a href="#cb18-479"></a></span>
+<span id="cb18-480"><a href="#cb18-480"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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diff --git a/stable/tables/lab-results/lbt14.html b/stable/tables/lab-results/lbt14.html
new file mode 100644
index 0000000000..e72270dbac
--- /dev/null
+++ b/stable/tables/lab-results/lbt14.html
@@ -0,0 +1,3089 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT14</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/lab-results/lbt15.html" rel="next">
+<link href="../../tables/lab-results/lbt13.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="../../site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="../../site_libs/quarto-html/quarto.js"></script>
+<script src="../../site_libs/quarto-html/popper.min.js"></script>
+<script src="../../site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="../../site_libs/quarto-html/anchor.min.js"></script>
+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="../../site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="../../site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark"><script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
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+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT14</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Results Shift Table – Highest NCI CTCAE Grade Post-Baseline by Baseline NCI CTCAE Grade</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table (High)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Standard Table (Low)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table Without Patients with <br> Missing Baseline (High)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Missing Baseline <br> Considered as Grade 0 (Low)</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table with Fill-In of Grades</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>Please note that for each variant, the <code>adlb</code> dataset needs to be filtered on correct flags like <code>WGRLOFL</code>, <code>WGRHIFL</code>, et al., otherwise the layout function will not return the correct counts. There is an option to create a record for a lab test where no record is found at that visit. If you specified <code>add_derived_type = "PHANTOM"</code> &amp; <code>dtype_phantom_cond</code>, you don’t have to use the <code>h_adsl_adlb_merge_using_worst_flag</code> function to preprocess your <code>adlb</code> dataset. Otherwise please follow the pre-processing steps below before applying the layout functions.</p>
+<div class="cell" data-hash="lbt14_cache/html/setup_9a7537bc056aeb9db0cbfd54899dcdc4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="co"># Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># selected properly.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>Note that the worst laboratory flag (below <code>WGRHIFL</code>) must be selected appropriately in the pre-processing step. New grouping variables <code>ATOXGR_GP</code> (post-baseline) and <code>BTOXGR_GP</code> (baseline) are created to display the correct output.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt14_cache/html/variant1_93d3ccd57165d4b489f0aeaad7ad3c93">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb2-5"><a href="#cb2-5"></a></span>
+<span id="cb2-6"><a href="#cb2-6"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb2-15"><a href="#cb2-15"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb2-17"><a href="#cb2-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb2-27"><a href="#cb2-27"></a>  )</span>
+<span id="cb2-28"><a href="#cb2-28"></a></span>
+<span id="cb2-29"><a href="#cb2-29"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb2-34"><a href="#cb2-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb2-36"><a href="#cb2-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb2-42"><a href="#cb2-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-43"><a href="#cb2-43"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb2-45"><a href="#cb2-45"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-46"><a href="#cb2-46"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb2-47"><a href="#cb2-47"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-48"><a href="#cb2-48"></a></span>
+<span id="cb2-49"><a href="#cb2-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                             
+      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
+              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                  
+      Not High                                   134          134            132      
+              Not High                        134 (100%)   134 (100%)     132 (100%)  
+C-Reactive Protein Measurement                                                        
+      Not High                                   114          112            115      
+              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  
+              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  
+              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   
+              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  
+              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   
+      1                                           8            10             7       
+              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   
+              1                                   0         1 (0.7%)          0       
+              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   
+      2                                           2            6              7       
+              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   
+              1                                   0         1 (0.7%)       2 (1.5%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              4                                   0            0           1 (0.8%)   
+      3                                           7            4              3       
+              Not High                         3 (2.2%)        0           2 (1.5%)   
+              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   
+              2                                   0         1 (0.7%)          0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     1 (0.7%)          0       
+      4                                           3            2              0       
+              Not High                         1 (0.7%)        0              0       
+              1                                   0         1 (0.7%)          0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)        0              0       
+Immunoglobulin A Measurement                                                          
+      Not High                                   119          116            113      
+              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  
+              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  
+              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  
+              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  
+              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   
+      1                                           5            4              2       
+              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              3                                   0         2 (1.5%)          0       
+      2                                           4            4              5       
+              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   
+              1                                1 (0.7%)        0           2 (1.5%)   
+              3                                1 (0.7%)        0              0       
+              4                                   0         1 (0.7%)          0       
+      3                                           4            5              11      
+              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   
+              1                                   0         1 (0.7%)       1 (0.8%)   
+              2                                1 (0.7%)        0              0       
+              3                                   0         2 (1.5%)       3 (2.3%)   
+              4                                   0         1 (0.7%)       1 (0.8%)   
+      4                                           2            5              1       
+              Not High                            0         3 (2.2%)       1 (0.8%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     1 (0.7%)          0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<p>Note that the worst laboratory flag (below <code>WGRLOFL</code>) must be selected appropriately in the pre-processing step. New grouping variables <code>ATOXGR_GP</code> (post-baseline) and <code>BTOXGR_GP</code> (baseline) are created to display the correct output.</p>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt14_cache/html/variant2_f4c3c1fa82221853bb12e15a8ed039fb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb4-8"><a href="#cb4-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb4-10"><a href="#cb4-10"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb4-11"><a href="#cb4-11"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb4-12"><a href="#cb4-12"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb4-21"><a href="#cb4-21"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb4-23"><a href="#cb4-23"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb4-24"><a href="#cb4-24"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb4-27"><a href="#cb4-27"></a>  )</span>
+<span id="cb4-28"><a href="#cb4-28"></a></span>
+<span id="cb4-29"><a href="#cb4-29"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-35"><a href="#cb4-35"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb4-36"><a href="#cb4-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb4-42"><a href="#cb4-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-46"><a href="#cb4-46"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb4-48"><a href="#cb4-48"></a></span>
+<span id="cb4-49"><a href="#cb4-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                             
+      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
+              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                  
+      Not Low                                    113          117            123      
+              Not Low                         56 (41.8%)   55 (41.0%)     62 (47.0%)  
+              1                               11 (8.2%)     9 (6.7%)      15 (11.4%)  
+              2                               15 (11.2%)   23 (17.2%)     16 (12.1%)  
+              3                               15 (11.2%)   21 (15.7%)     13 (9.8%)   
+              4                               16 (11.9%)    9 (6.7%)      17 (12.9%)  
+      1                                           6            6              4       
+              Not Low                          3 (2.2%)     5 (3.7%)       3 (2.3%)   
+              1                                3 (2.2%)        0              0       
+              4                                   0         1 (0.7%)       1 (0.8%)   
+      2                                           8            5              1       
+              Not Low                          5 (3.7%)     3 (2.2%)          0       
+              1                                   0         1 (0.7%)          0       
+              2                                2 (1.5%)        0              0       
+              3                                   0         1 (0.7%)       1 (0.8%)   
+              4                                1 (0.7%)        0              0       
+      3                                           3            3              2       
+              Not Low                             0         1 (0.7%)          0       
+              1                                1 (0.7%)        0              0       
+              2                                1 (0.7%)        0           1 (0.8%)   
+              3                                1 (0.7%)     2 (1.5%)       1 (0.8%)   
+      4                                           4            3              2       
+              Not Low                          4 (3.0%)     1 (0.7%)       1 (0.8%)   
+              1                                   0         1 (0.7%)          0       
+              2                                   0         1 (0.7%)          0       
+              3                                   0            0           1 (0.8%)   
+C-Reactive Protein Measurement                                                        
+      Not Low                                    119          113            112      
+              Not Low                         41 (30.6%)   42 (31.3%)     50 (37.9%)  
+              1                               20 (14.9%)   18 (13.4%)     11 (8.3%)   
+              2                               24 (17.9%)   20 (14.9%)     14 (10.6%)  
+              3                               25 (18.7%)   18 (13.4%)     21 (15.9%)  
+              4                                9 (6.7%)    15 (11.2%)     16 (12.1%)  
+      1                                           3            5              9       
+              Not Low                          2 (1.5%)     2 (1.5%)       2 (1.5%)   
+              2                                   0         1 (0.7%)       3 (2.3%)   
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                   0         1 (0.7%)       4 (3.0%)   
+      2                                           5            9              2       
+              Not Low                          3 (2.2%)     4 (3.0%)       1 (0.8%)   
+              1                                1 (0.7%)     4 (3.0%)          0       
+              3                                   0         1 (0.7%)       1 (0.8%)   
+              4                                1 (0.7%)        0              0       
+      3                                           4            5              7       
+              Not Low                          1 (0.7%)     4 (3.0%)       2 (1.5%)   
+              1                                   0            0           1 (0.8%)   
+              2                                   0            0           1 (0.8%)   
+              3                                3 (2.2%)     1 (0.7%)       2 (1.5%)   
+              4                                   0            0           1 (0.8%)   
+      4                                           3            2              2       
+              Not Low                          3 (2.2%)     1 (0.7%)          0       
+              2                                   0         1 (0.7%)          0       
+              3                                   0            0           1 (0.8%)   
+              4                                   0            0           1 (0.8%)   
+Immunoglobulin A Measurement                                                          
+      Not Low                                    134          134            132      
+              Not Low                         134 (100%)   134 (100%)     132 (100%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>Note that missing baseline values are filtered out in the pre-processing step.</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="lbt14_cache/html/variant3_0a5d0119b55d8b86f27809cbb37bae5a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb6-5"><a href="#cb6-5"></a></span>
+<span id="cb6-6"><a href="#cb6-6"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">filter</span>(BTOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb6-11"><a href="#cb6-11"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb6-21"><a href="#cb6-21"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb6-23"><a href="#cb6-23"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb6-25"><a href="#cb6-25"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb6-27"><a href="#cb6-27"></a>  )</span>
+<span id="cb6-28"><a href="#cb6-28"></a></span>
+<span id="cb6-29"><a href="#cb6-29"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb6-33"><a href="#cb6-33"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-38"><a href="#cb6-38"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb6-39"><a href="#cb6-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb6-42"><a href="#cb6-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-44"><a href="#cb6-44"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb6-47"><a href="#cb6-47"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb6-48"><a href="#cb6-48"></a></span>
+<span id="cb6-49"><a href="#cb6-49"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                             
+      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
+              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                  
+      Not High                                   134          134            132      
+              Not High                        134 (100%)   134 (100%)     132 (100%)  
+C-Reactive Protein Measurement                                                        
+      Not High                                   114          112            115      
+              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  
+              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  
+              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   
+              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  
+              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   
+      1                                           8            10             7       
+              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   
+              1                                   0         1 (0.7%)          0       
+              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   
+      2                                           2            6              7       
+              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   
+              1                                   0         1 (0.7%)       2 (1.5%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              4                                   0            0           1 (0.8%)   
+      3                                           7            4              3       
+              Not High                         3 (2.2%)        0           2 (1.5%)   
+              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   
+              2                                   0         1 (0.7%)          0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     1 (0.7%)          0       
+      4                                           3            2              0       
+              Not High                         1 (0.7%)        0              0       
+              1                                   0         1 (0.7%)          0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)        0              0       
+Immunoglobulin A Measurement                                                          
+      Not High                                   119          116            113      
+              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  
+              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  
+              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  
+              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  
+              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   
+      1                                           5            4              2       
+              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              3                                   0         2 (1.5%)          0       
+      2                                           4            4              5       
+              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   
+              1                                1 (0.7%)        0           2 (1.5%)   
+              3                                1 (0.7%)        0              0       
+              4                                   0         1 (0.7%)          0       
+      3                                           4            5              11      
+              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   
+              1                                   0         1 (0.7%)       1 (0.8%)   
+              2                                1 (0.7%)        0              0       
+              3                                   0         2 (1.5%)       3 (2.3%)   
+              4                                   0         1 (0.7%)       1 (0.8%)   
+      4                                           2            5              1       
+              Not High                            0         3 (2.2%)       1 (0.8%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     1 (0.7%)          0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Note that when BTOXGR is missing, the grouping variable <code>BTOXGR_GP</code> now is <code>"Not Low"</code> instead of <code>"Missing"</code> compared to <em>Standard Table (Low)</em>.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="lbt14_cache/html/variant4_994cbd9061ced1d08f2b653623782178">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb8-8"><a href="#cb8-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb8-10"><a href="#cb8-10"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb8-11"><a href="#cb8-11"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb8-12"><a href="#cb8-12"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb8-14"><a href="#cb8-14"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb8-16"><a href="#cb8-16"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb8-17"><a href="#cb8-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb8-20"><a href="#cb8-20"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>, <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb8-21"><a href="#cb8-21"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb8-22"><a href="#cb8-22"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb8-23"><a href="#cb8-23"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb8-24"><a href="#cb8-24"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb8-26"><a href="#cb8-26"></a>  )</span>
+<span id="cb8-27"><a href="#cb8-27"></a></span>
+<span id="cb8-28"><a href="#cb8-28"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb8-33"><a href="#cb8-33"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb8-40"><a href="#cb8-40"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb8-41"><a href="#cb8-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb8-47"><a href="#cb8-47"></a></span>
+<span id="cb8-48"><a href="#cb8-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                             
+      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
+              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                  
+      Not Low                                    113          117            123      
+              Not Low                         56 (41.8%)   55 (41.0%)     62 (47.0%)  
+              1                               11 (8.2%)     9 (6.7%)      15 (11.4%)  
+              2                               15 (11.2%)   23 (17.2%)     16 (12.1%)  
+              3                               15 (11.2%)   21 (15.7%)     13 (9.8%)   
+              4                               16 (11.9%)    9 (6.7%)      17 (12.9%)  
+      1                                           6            6              4       
+              Not Low                          3 (2.2%)     5 (3.7%)       3 (2.3%)   
+              1                                3 (2.2%)        0              0       
+              4                                   0         1 (0.7%)       1 (0.8%)   
+      2                                           8            5              1       
+              Not Low                          5 (3.7%)     3 (2.2%)          0       
+              1                                   0         1 (0.7%)          0       
+              2                                2 (1.5%)        0              0       
+              3                                   0         1 (0.7%)       1 (0.8%)   
+              4                                1 (0.7%)        0              0       
+      3                                           3            3              2       
+              Not Low                             0         1 (0.7%)          0       
+              1                                1 (0.7%)        0              0       
+              2                                1 (0.7%)        0           1 (0.8%)   
+              3                                1 (0.7%)     2 (1.5%)       1 (0.8%)   
+      4                                           4            3              2       
+              Not Low                          4 (3.0%)     1 (0.7%)       1 (0.8%)   
+              1                                   0         1 (0.7%)          0       
+              2                                   0         1 (0.7%)          0       
+              3                                   0            0           1 (0.8%)   
+C-Reactive Protein Measurement                                                        
+      Not Low                                    119          113            112      
+              Not Low                         41 (30.6%)   42 (31.3%)     50 (37.9%)  
+              1                               20 (14.9%)   18 (13.4%)     11 (8.3%)   
+              2                               24 (17.9%)   20 (14.9%)     14 (10.6%)  
+              3                               25 (18.7%)   18 (13.4%)     21 (15.9%)  
+              4                                9 (6.7%)    15 (11.2%)     16 (12.1%)  
+      1                                           3            5              9       
+              Not Low                          2 (1.5%)     2 (1.5%)       2 (1.5%)   
+              2                                   0         1 (0.7%)       3 (2.3%)   
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                   0         1 (0.7%)       4 (3.0%)   
+      2                                           5            9              2       
+              Not Low                          3 (2.2%)     4 (3.0%)       1 (0.8%)   
+              1                                1 (0.7%)     4 (3.0%)          0       
+              3                                   0         1 (0.7%)       1 (0.8%)   
+              4                                1 (0.7%)        0              0       
+      3                                           4            5              7       
+              Not Low                          1 (0.7%)     4 (3.0%)       2 (1.5%)   
+              1                                   0            0           1 (0.8%)   
+              2                                   0            0           1 (0.8%)   
+              3                                3 (2.2%)     1 (0.7%)       2 (1.5%)   
+              4                                   0            0           1 (0.8%)   
+      4                                           3            2              2       
+              Not Low                          3 (2.2%)     1 (0.7%)          0       
+              2                                   0         1 (0.7%)          0       
+              3                                   0            0           1 (0.8%)   
+              4                                   0            0           1 (0.8%)   
+Immunoglobulin A Measurement                                                          
+      Not Low                                    134          134            132      
+              Not Low                         134 (100%)   134 (100%)     132 (100%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Pre-processing is the same as <em>Standard Table (High)</em>, but in order to keep all levels, <code>prune_table()</code> is not applied.</p>
+<div class="cell" data-test="{&quot;result_v5&quot;:&quot;result&quot;}" data-hash="lbt14_cache/html/variant5_df4e5ba10f0c32cea05867d38842fc3e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb10-8"><a href="#cb10-8"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb10-10"><a href="#cb10-10"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb10-11"><a href="#cb10-11"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb10-12"><a href="#cb10-12"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb10-13"><a href="#cb10-13"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb10-14"><a href="#cb10-14"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb10-15"><a href="#cb10-15"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb10-17"><a href="#cb10-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-18"><a href="#cb10-18"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-19"><a href="#cb10-19"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb10-20"><a href="#cb10-20"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb10-22"><a href="#cb10-22"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb10-23"><a href="#cb10-23"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb10-24"><a href="#cb10-24"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb10-25"><a href="#cb10-25"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb10-26"><a href="#cb10-26"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb10-27"><a href="#cb10-27"></a>  )</span>
+<span id="cb10-28"><a href="#cb10-28"></a></span>
+<span id="cb10-29"><a href="#cb10-29"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-35"><a href="#cb10-35"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb10-38"><a href="#cb10-38"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb10-39"><a href="#cb10-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb10-40"><a href="#cb10-40"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb10-42"><a href="#cb10-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb10-47"><a href="#cb10-47"></a></span>
+<span id="cb10-48"><a href="#cb10-48"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Parameter                                                                             
+      Baseline NCI-CTCAE Grade                A: Drug X    B: Placebo   C: Combination
+              Post-baseline NCI-CTCAE Grade    (N=134)      (N=134)        (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————
+Alanine Aminotransferase Measurement                                                  
+      Not High                                   134          134            132      
+              Not High                        134 (100%)   134 (100%)     132 (100%)  
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      1                                           0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      2                                           0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      3                                           0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      4                                           0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      Missing                                     0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+C-Reactive Protein Measurement                                                        
+      Not High                                   114          112            115      
+              Not High                        45 (33.6%)   55 (41.0%)     57 (43.2%)  
+              1                               18 (13.4%)   18 (13.4%)     19 (14.4%)  
+              2                               19 (14.2%)   10 (7.5%)      11 (8.3%)   
+              3                               22 (16.4%)   13 (9.7%)      20 (15.2%)  
+              4                               10 (7.5%)    16 (11.9%)      8 (6.1%)   
+              Missing                             0            0              0       
+      1                                           8            10             7       
+              Not High                         5 (3.7%)     2 (1.5%)       2 (1.5%)   
+              1                                   0         1 (0.7%)          0       
+              2                                1 (0.7%)     3 (2.2%)       3 (2.3%)   
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     3 (2.2%)       2 (1.5%)   
+              Missing                             0            0              0       
+      2                                           2            6              7       
+              Not High                         1 (0.7%)     4 (3.0%)       4 (3.0%)   
+              1                                   0         1 (0.7%)       2 (1.5%)   
+              2                                1 (0.7%)     1 (0.7%)          0       
+              3                                   0            0              0       
+              4                                   0            0           1 (0.8%)   
+              Missing                             0            0              0       
+      3                                           7            4              3       
+              Not High                         3 (2.2%)        0           2 (1.5%)   
+              1                                2 (1.5%)     1 (0.7%)       1 (0.8%)   
+              2                                   0         1 (0.7%)          0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)     1 (0.7%)          0       
+              Missing                             0            0              0       
+      4                                           3            2              0       
+              Not High                         1 (0.7%)        0              0       
+              1                                   0         1 (0.7%)          0       
+              2                                   0            0              0       
+              3                                1 (0.7%)     1 (0.7%)          0       
+              4                                1 (0.7%)        0              0       
+              Missing                             0            0              0       
+      Missing                                     0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+Immunoglobulin A Measurement                                                          
+      Not High                                   119          116            113      
+              Not High                        55 (41.0%)   54 (40.3%)     51 (38.6%)  
+              1                               18 (13.4%)   11 (8.2%)      15 (11.4%)  
+              2                               14 (10.4%)   22 (16.4%)     19 (14.4%)  
+              3                               20 (14.9%)   19 (14.2%)     20 (15.2%)  
+              4                               12 (9.0%)    10 (7.5%)       8 (6.1%)   
+              Missing                             0            0              0       
+      1                                           5            4              2       
+              Not High                         4 (3.0%)     1 (0.7%)       2 (1.5%)   
+              1                                   0            0              0       
+              2                                1 (0.7%)     1 (0.7%)          0       
+              3                                   0         2 (1.5%)          0       
+              4                                   0            0              0       
+              Missing                             0            0              0       
+      2                                           4            4              5       
+              Not High                         2 (1.5%)     3 (2.2%)       3 (2.3%)   
+              1                                1 (0.7%)        0           2 (1.5%)   
+              2                                   0            0              0       
+              3                                1 (0.7%)        0              0       
+              4                                   0         1 (0.7%)          0       
+              Missing                             0            0              0       
+      3                                           4            5              11      
+              Not High                         3 (2.2%)     1 (0.7%)       6 (4.5%)   
+              1                                   0         1 (0.7%)       1 (0.8%)   
+              2                                1 (0.7%)        0              0       
+              3                                   0         2 (1.5%)       3 (2.3%)   
+              4                                   0         1 (0.7%)       1 (0.8%)   
+              Missing                             0            0              0       
+      4                                           2            5              1       
+              Not High                            0         3 (2.2%)       1 (0.8%)   
+              1                                   0            0              0       
+              2                                1 (0.7%)     1 (0.7%)          0       
+              3                                   0            0              0       
+              4                                1 (0.7%)     1 (0.7%)          0       
+              Missing                             0            0              0       
+      Missing                                     0            0              0       
+              Not High                            0            0              0       
+              1                                   0            0              0       
+              2                                   0            0              0       
+              3                                   0            0              0       
+              4                                   0            0              0       
+              Missing                             0            0              0       </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:16}" data-hash="lbt14_cache/html/teal_5ee7f171e664baf3ea06ec8ff193cd82">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-4"><a href="#cb12-4"></a></span>
+<span id="cb12-5"><a href="#cb12-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-6"><a href="#cb12-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-9"><a href="#cb12-9"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-10"><a href="#cb12-10"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-11"><a href="#cb12-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb12-12"><a href="#cb12-12"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb12-13"><a href="#cb12-13"></a>    ),</span>
+<span id="cb12-14"><a href="#cb12-14"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a>  ),</span>
+<span id="cb12-16"><a href="#cb12-16"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-17"><a href="#cb12-17"></a>    <span class="fu">tm_t_shift_by_grade</span>(</span>
+<span id="cb12-18"><a href="#cb12-18"></a>      <span class="at">label =</span> <span class="st">"Grade Laboratory Abnormality Table"</span>,</span>
+<span id="cb12-19"><a href="#cb12-19"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb12-20"><a href="#cb12-20"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-21"><a href="#cb12-21"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-22"><a href="#cb12-22"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-23"><a href="#cb12-23"></a>      ),</span>
+<span id="cb12-24"><a href="#cb12-24"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-25"><a href="#cb12-25"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-26"><a href="#cb12-26"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a>      ),</span>
+<span id="cb12-28"><a href="#cb12-28"></a>      <span class="at">worst_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-29"><a href="#cb12-29"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>, <span class="st">"WGRLOFL"</span>, <span class="st">"WGRHIVFL"</span>, <span class="st">"WGRHIFL"</span>)),</span>
+<span id="cb12-30"><a href="#cb12-30"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span>)</span>
+<span id="cb12-31"><a href="#cb12-31"></a>      ),</span>
+<span id="cb12-32"><a href="#cb12-32"></a>      <span class="at">worst_flag_indicator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-33"><a href="#cb12-33"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"WGRLOVFL"</span>),</span>
+<span id="cb12-34"><a href="#cb12-34"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-35"><a href="#cb12-35"></a>      ),</span>
+<span id="cb12-36"><a href="#cb12-36"></a>      <span class="at">anl_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-37"><a href="#cb12-37"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>)),</span>
+<span id="cb12-38"><a href="#cb12-38"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>),</span>
+<span id="cb12-39"><a href="#cb12-39"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>      ),</span>
+<span id="cb12-41"><a href="#cb12-41"></a>      <span class="at">base_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-42"><a href="#cb12-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>)),</span>
+<span id="cb12-43"><a href="#cb12-43"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>),</span>
+<span id="cb12-44"><a href="#cb12-44"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>      ),</span>
+<span id="cb12-46"><a href="#cb12-46"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>    )</span>
+<span id="cb12-48"><a href="#cb12-48"></a>  ),</span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-51"><a href="#cb12-51"></a>  )</span>
+<span id="cb12-52"><a href="#cb12-52"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:25:36.8336 pid:11943 token:[] teal.modules.clinical Initializing tm_t_shift_by_grade</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt14_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt14_cache/html/sessioninfo_0653ebbc1a5a722821d9f848368a0b5c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt14_cache/html/snapshot_f01fc43823d2f1923492134f0b769bfc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb17"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb17-1"><a href="#cb17-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-2"><a href="#cb17-2"></a></span>
+<span id="cb17-3"><a href="#cb17-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb17-4"><a href="#cb17-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb17-5"><a href="#cb17-5"></a></span>
+<span id="cb17-6"><a href="#cb17-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb17-7"><a href="#cb17-7"></a></span>
+<span id="cb17-8"><a href="#cb17-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb17-9"><a href="#cb17-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb17-10"><a href="#cb17-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb17-11"><a href="#cb17-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt14.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
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+<div class="sourceCode" id="cb18" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb18-1"><a href="#cb18-1"></a><span class="co">---</span></span>
+<span id="cb18-2"><a href="#cb18-2"></a><span class="an">title:</span><span class="co"> LBT14</span></span>
+<span id="cb18-3"><a href="#cb18-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Results Shift Table -- Highest NCI CTCAE Grade Post-Baseline by Baseline NCI CTCAE Grade</span></span>
+<span id="cb18-4"><a href="#cb18-4"></a><span class="co">---</span></span>
+<span id="cb18-5"><a href="#cb18-5"></a></span>
+<span id="cb18-6"><a href="#cb18-6"></a>------------------------------------------------------------------------</span>
+<span id="cb18-7"><a href="#cb18-7"></a></span>
+<span id="cb18-8"><a href="#cb18-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb18-9"><a href="#cb18-9"></a></span>
+<span id="cb18-10"><a href="#cb18-10"></a>::: panel-tabset</span>
+<span id="cb18-11"><a href="#cb18-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb18-12"><a href="#cb18-12"></a></span>
+<span id="cb18-13"><a href="#cb18-13"></a>Please note that for each variant, the <span class="in">`adlb`</span> dataset needs to be filtered on correct flags like <span class="in">`WGRLOFL`</span>, <span class="in">`WGRHIFL`</span>, et al., otherwise the layout function will not return the correct counts.</span>
+<span id="cb18-14"><a href="#cb18-14"></a>There is an option to create a record for a lab test where no record is found at that visit.</span>
+<span id="cb18-15"><a href="#cb18-15"></a>If you specified <span class="in">`add_derived_type = "PHANTOM"`</span> &amp; <span class="in">`dtype_phantom_cond`</span>, you don't have to use the <span class="in">`h_adsl_adlb_merge_using_worst_flag`</span> function to preprocess your <span class="in">`adlb`</span> dataset.</span>
+<span id="cb18-16"><a href="#cb18-16"></a>Otherwise please follow the pre-processing steps below before applying the layout functions.</span>
+<span id="cb18-17"><a href="#cb18-17"></a></span>
+<span id="cb18-18"><a href="#cb18-18"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb18-19"><a href="#cb18-19"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb18-20"><a href="#cb18-20"></a></span>
+<span id="cb18-21"><a href="#cb18-21"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-22"><a href="#cb18-22"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-23"><a href="#cb18-23"></a><span class="fu">library</span>(tern)</span>
+<span id="cb18-24"><a href="#cb18-24"></a></span>
+<span id="cb18-25"><a href="#cb18-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-26"><a href="#cb18-26"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb18-27"><a href="#cb18-27"></a></span>
+<span id="cb18-28"><a href="#cb18-28"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb18-29"><a href="#cb18-29"></a>adlb <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adlb)</span>
+<span id="cb18-30"><a href="#cb18-30"></a></span>
+<span id="cb18-31"><a href="#cb18-31"></a><span class="co"># Please note that in real clinical data, population flag like SAFFL, and parameter category like PARCAT2 needs to be</span></span>
+<span id="cb18-32"><a href="#cb18-32"></a><span class="co"># selected properly.</span></span>
+<span id="cb18-33"><a href="#cb18-33"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-34"><a href="#cb18-34"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-35"><a href="#cb18-35"></a><span class="in">```</span></span>
+<span id="cb18-36"><a href="#cb18-36"></a></span>
+<span id="cb18-37"><a href="#cb18-37"></a><span class="fu">## Standard Table (High)</span></span>
+<span id="cb18-38"><a href="#cb18-38"></a></span>
+<span id="cb18-39"><a href="#cb18-39"></a>Note that the worst laboratory flag (below <span class="in">`WGRHIFL`</span>) must be selected appropriately in the pre-processing step.</span>
+<span id="cb18-40"><a href="#cb18-40"></a>New grouping variables <span class="in">`ATOXGR_GP`</span> (post-baseline) and <span class="in">`BTOXGR_GP`</span> (baseline) are created to display the correct output.</span>
+<span id="cb18-41"><a href="#cb18-41"></a></span>
+<span id="cb18-42"><a href="#cb18-42"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb18-43"><a href="#cb18-43"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-44"><a href="#cb18-44"></a></span>
+<span id="cb18-45"><a href="#cb18-45"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-46"><a href="#cb18-46"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb18-47"><a href="#cb18-47"></a></span>
+<span id="cb18-48"><a href="#cb18-48"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-49"><a href="#cb18-49"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-50"><a href="#cb18-50"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-51"><a href="#cb18-51"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-52"><a href="#cb18-52"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-53"><a href="#cb18-53"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-54"><a href="#cb18-54"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-55"><a href="#cb18-55"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-56"><a href="#cb18-56"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-57"><a href="#cb18-57"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-58"><a href="#cb18-58"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-59"><a href="#cb18-59"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-60"><a href="#cb18-60"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-61"><a href="#cb18-61"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-62"><a href="#cb18-62"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-63"><a href="#cb18-63"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-64"><a href="#cb18-64"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-65"><a href="#cb18-65"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-66"><a href="#cb18-66"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-67"><a href="#cb18-67"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-68"><a href="#cb18-68"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-69"><a href="#cb18-69"></a>  )</span>
+<span id="cb18-70"><a href="#cb18-70"></a></span>
+<span id="cb18-71"><a href="#cb18-71"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-72"><a href="#cb18-72"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-73"><a href="#cb18-73"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-74"><a href="#cb18-74"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb18-75"><a href="#cb18-75"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb18-76"><a href="#cb18-76"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-77"><a href="#cb18-77"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb18-78"><a href="#cb18-78"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-79"><a href="#cb18-79"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-80"><a href="#cb18-80"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb18-81"><a href="#cb18-81"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-82"><a href="#cb18-82"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb18-83"><a href="#cb18-83"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb18-84"><a href="#cb18-84"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-85"><a href="#cb18-85"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-86"><a href="#cb18-86"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-87"><a href="#cb18-87"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-88"><a href="#cb18-88"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb18-89"><a href="#cb18-89"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb18-90"><a href="#cb18-90"></a></span>
+<span id="cb18-91"><a href="#cb18-91"></a>result</span>
+<span id="cb18-92"><a href="#cb18-92"></a><span class="in">```</span></span>
+<span id="cb18-93"><a href="#cb18-93"></a></span>
+<span id="cb18-94"><a href="#cb18-94"></a><span class="fu">## Standard Table (Low)</span></span>
+<span id="cb18-95"><a href="#cb18-95"></a></span>
+<span id="cb18-96"><a href="#cb18-96"></a>Note that the worst laboratory flag (below <span class="in">`WGRLOFL`</span>) must be selected appropriately in the pre-processing step.</span>
+<span id="cb18-97"><a href="#cb18-97"></a>New grouping variables <span class="in">`ATOXGR_GP`</span> (post-baseline) and <span class="in">`BTOXGR_GP`</span> (baseline) are created to display the correct output.</span>
+<span id="cb18-98"><a href="#cb18-98"></a></span>
+<span id="cb18-99"><a href="#cb18-99"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb18-100"><a href="#cb18-100"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-101"><a href="#cb18-101"></a></span>
+<span id="cb18-102"><a href="#cb18-102"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-103"><a href="#cb18-103"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb18-104"><a href="#cb18-104"></a></span>
+<span id="cb18-105"><a href="#cb18-105"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-106"><a href="#cb18-106"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-107"><a href="#cb18-107"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-108"><a href="#cb18-108"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-109"><a href="#cb18-109"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-110"><a href="#cb18-110"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-111"><a href="#cb18-111"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-112"><a href="#cb18-112"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-113"><a href="#cb18-113"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-114"><a href="#cb18-114"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-115"><a href="#cb18-115"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-116"><a href="#cb18-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-117"><a href="#cb18-117"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-118"><a href="#cb18-118"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-119"><a href="#cb18-119"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-120"><a href="#cb18-120"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-121"><a href="#cb18-121"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-122"><a href="#cb18-122"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-123"><a href="#cb18-123"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-124"><a href="#cb18-124"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-125"><a href="#cb18-125"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-126"><a href="#cb18-126"></a>  )</span>
+<span id="cb18-127"><a href="#cb18-127"></a></span>
+<span id="cb18-128"><a href="#cb18-128"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-129"><a href="#cb18-129"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-130"><a href="#cb18-130"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-131"><a href="#cb18-131"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb18-132"><a href="#cb18-132"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb18-133"><a href="#cb18-133"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-134"><a href="#cb18-134"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb18-135"><a href="#cb18-135"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-136"><a href="#cb18-136"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-137"><a href="#cb18-137"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb18-138"><a href="#cb18-138"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-139"><a href="#cb18-139"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb18-140"><a href="#cb18-140"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb18-141"><a href="#cb18-141"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-142"><a href="#cb18-142"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-143"><a href="#cb18-143"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-144"><a href="#cb18-144"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-145"><a href="#cb18-145"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb18-146"><a href="#cb18-146"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb18-147"><a href="#cb18-147"></a></span>
+<span id="cb18-148"><a href="#cb18-148"></a>result</span>
+<span id="cb18-149"><a href="#cb18-149"></a><span class="in">```</span></span>
+<span id="cb18-150"><a href="#cb18-150"></a></span>
+<span id="cb18-151"><a href="#cb18-151"></a><span class="fu">## Table Without Patients with &lt;br/&gt; Missing Baseline (High)</span></span>
+<span id="cb18-152"><a href="#cb18-152"></a></span>
+<span id="cb18-153"><a href="#cb18-153"></a>Note that missing baseline values are filtered out in the pre-processing step.</span>
+<span id="cb18-154"><a href="#cb18-154"></a></span>
+<span id="cb18-155"><a href="#cb18-155"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb18-156"><a href="#cb18-156"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-157"><a href="#cb18-157"></a></span>
+<span id="cb18-158"><a href="#cb18-158"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-159"><a href="#cb18-159"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb18-160"><a href="#cb18-160"></a></span>
+<span id="cb18-161"><a href="#cb18-161"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-162"><a href="#cb18-162"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-163"><a href="#cb18-163"></a>  <span class="fu">filter</span>(BTOXGR <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-164"><a href="#cb18-164"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-165"><a href="#cb18-165"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-166"><a href="#cb18-166"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-167"><a href="#cb18-167"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-168"><a href="#cb18-168"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-169"><a href="#cb18-169"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-170"><a href="#cb18-170"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-171"><a href="#cb18-171"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-172"><a href="#cb18-172"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-173"><a href="#cb18-173"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-174"><a href="#cb18-174"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-175"><a href="#cb18-175"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-176"><a href="#cb18-176"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-177"><a href="#cb18-177"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-178"><a href="#cb18-178"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-179"><a href="#cb18-179"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-180"><a href="#cb18-180"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb18-181"><a href="#cb18-181"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb18-182"><a href="#cb18-182"></a>  )</span>
+<span id="cb18-183"><a href="#cb18-183"></a></span>
+<span id="cb18-184"><a href="#cb18-184"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-185"><a href="#cb18-185"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-186"><a href="#cb18-186"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-187"><a href="#cb18-187"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb18-188"><a href="#cb18-188"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb18-189"><a href="#cb18-189"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-190"><a href="#cb18-190"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb18-191"><a href="#cb18-191"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-192"><a href="#cb18-192"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-193"><a href="#cb18-193"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb18-194"><a href="#cb18-194"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-195"><a href="#cb18-195"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb18-196"><a href="#cb18-196"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb18-197"><a href="#cb18-197"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-198"><a href="#cb18-198"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-199"><a href="#cb18-199"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-200"><a href="#cb18-200"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-201"><a href="#cb18-201"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb18-202"><a href="#cb18-202"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb18-203"><a href="#cb18-203"></a></span>
+<span id="cb18-204"><a href="#cb18-204"></a>result</span>
+<span id="cb18-205"><a href="#cb18-205"></a><span class="in">```</span></span>
+<span id="cb18-206"><a href="#cb18-206"></a></span>
+<span id="cb18-207"><a href="#cb18-207"></a><span class="fu">## Table with Missing Baseline &lt;br/&gt; Considered as Grade 0 (Low)</span></span>
+<span id="cb18-208"><a href="#cb18-208"></a></span>
+<span id="cb18-209"><a href="#cb18-209"></a>Note that when BTOXGR is missing, the grouping variable <span class="in">`BTOXGR_GP`</span> now is <span class="in">`"Not Low"`</span> instead of <span class="in">`"Missing"`</span> compared to *Standard Table (Low)*.</span>
+<span id="cb18-210"><a href="#cb18-210"></a></span>
+<span id="cb18-211"><a href="#cb18-211"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb18-212"><a href="#cb18-212"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRLOFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-213"><a href="#cb18-213"></a></span>
+<span id="cb18-214"><a href="#cb18-214"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-215"><a href="#cb18-215"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRLOFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb18-216"><a href="#cb18-216"></a></span>
+<span id="cb18-217"><a href="#cb18-217"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-218"><a href="#cb18-218"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-219"><a href="#cb18-219"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-220"><a href="#cb18-220"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-221"><a href="#cb18-221"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-222"><a href="#cb18-222"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-223"><a href="#cb18-223"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-224"><a href="#cb18-224"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-225"><a href="#cb18-225"></a>      ATOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-226"><a href="#cb18-226"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-227"><a href="#cb18-227"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>))</span>
+<span id="cb18-228"><a href="#cb18-228"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-229"><a href="#cb18-229"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-230"><a href="#cb18-230"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-231"><a href="#cb18-231"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="dv">1</span>, <span class="dv">2</span>, <span class="dv">3</span>, <span class="dv">4</span>, <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">~</span> <span class="st">"Not Low"</span>,</span>
+<span id="cb18-232"><a href="#cb18-232"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-233"><a href="#cb18-233"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-234"><a href="#cb18-234"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-235"><a href="#cb18-235"></a>      BTOXGR <span class="sc">==</span> <span class="sc">-</span><span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span></span>
+<span id="cb18-236"><a href="#cb18-236"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not Low"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-237"><a href="#cb18-237"></a>  )</span>
+<span id="cb18-238"><a href="#cb18-238"></a></span>
+<span id="cb18-239"><a href="#cb18-239"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-240"><a href="#cb18-240"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-241"><a href="#cb18-241"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-242"><a href="#cb18-242"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb18-243"><a href="#cb18-243"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb18-244"><a href="#cb18-244"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-245"><a href="#cb18-245"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb18-246"><a href="#cb18-246"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-247"><a href="#cb18-247"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-248"><a href="#cb18-248"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb18-249"><a href="#cb18-249"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-250"><a href="#cb18-250"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb18-251"><a href="#cb18-251"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb18-252"><a href="#cb18-252"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-253"><a href="#cb18-253"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-254"><a href="#cb18-254"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-255"><a href="#cb18-255"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-256"><a href="#cb18-256"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb18-257"><a href="#cb18-257"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb18-258"><a href="#cb18-258"></a></span>
+<span id="cb18-259"><a href="#cb18-259"></a>result</span>
+<span id="cb18-260"><a href="#cb18-260"></a><span class="in">```</span></span>
+<span id="cb18-261"><a href="#cb18-261"></a></span>
+<span id="cb18-262"><a href="#cb18-262"></a><span class="fu">## Table with Fill-In of Grades</span></span>
+<span id="cb18-263"><a href="#cb18-263"></a></span>
+<span id="cb18-264"><a href="#cb18-264"></a>Pre-processing is the same as *Standard Table (High)*, but in order to keep all levels, <span class="in">`prune_table()`</span> is not applied.</span>
+<span id="cb18-265"><a href="#cb18-265"></a></span>
+<span id="cb18-266"><a href="#cb18-266"></a><span class="in">```{r variant5, test = list(result_v5 = "result")}</span></span>
+<span id="cb18-267"><a href="#cb18-267"></a>adlb_f <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">filter</span>(WGRHIFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-268"><a href="#cb18-268"></a></span>
+<span id="cb18-269"><a href="#cb18-269"></a><span class="co"># Please note the step below can be skipped if you are using DTYPE PHANTOM</span></span>
+<span id="cb18-270"><a href="#cb18-270"></a>adlb_out <span class="ot">&lt;-</span> <span class="fu">h_adsl_adlb_merge_using_worst_flag</span>(adsl_f, adlb_f, <span class="at">worst_flag =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span> <span class="ot">=</span> <span class="st">"Y"</span>))</span>
+<span id="cb18-271"><a href="#cb18-271"></a></span>
+<span id="cb18-272"><a href="#cb18-272"></a><span class="co"># Create new grouping variables ATOXGR_GP, BTOXGR_GP</span></span>
+<span id="cb18-273"><a href="#cb18-273"></a>adlb_out <span class="ot">&lt;-</span> adlb_out <span class="sc">%&gt;%</span></span>
+<span id="cb18-274"><a href="#cb18-274"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-275"><a href="#cb18-275"></a>    <span class="at">ATOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-276"><a href="#cb18-276"></a>      ATOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-277"><a href="#cb18-277"></a>      ATOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-278"><a href="#cb18-278"></a>      ATOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-279"><a href="#cb18-279"></a>      ATOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-280"><a href="#cb18-280"></a>      ATOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-281"><a href="#cb18-281"></a>      ATOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-282"><a href="#cb18-282"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-283"><a href="#cb18-283"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-284"><a href="#cb18-284"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb18-285"><a href="#cb18-285"></a>    <span class="at">BTOXGR_GP =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb18-286"><a href="#cb18-286"></a>      BTOXGR <span class="sc">%in%</span> <span class="fu">c</span>(<span class="dv">0</span>, <span class="sc">-</span><span class="dv">1</span>, <span class="sc">-</span><span class="dv">2</span>, <span class="sc">-</span><span class="dv">3</span>, <span class="sc">-</span><span class="dv">4</span>) <span class="sc">~</span> <span class="st">"Not High"</span>,</span>
+<span id="cb18-287"><a href="#cb18-287"></a>      BTOXGR <span class="sc">==</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"1"</span>,</span>
+<span id="cb18-288"><a href="#cb18-288"></a>      BTOXGR <span class="sc">==</span> <span class="dv">2</span> <span class="sc">~</span> <span class="st">"2"</span>,</span>
+<span id="cb18-289"><a href="#cb18-289"></a>      BTOXGR <span class="sc">==</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"3"</span>,</span>
+<span id="cb18-290"><a href="#cb18-290"></a>      BTOXGR <span class="sc">==</span> <span class="dv">4</span> <span class="sc">~</span> <span class="st">"4"</span>,</span>
+<span id="cb18-291"><a href="#cb18-291"></a>      BTOXGR <span class="sc">==</span> <span class="st">"&lt;Missing&gt;"</span> <span class="sc">~</span> <span class="st">"Missing"</span></span>
+<span id="cb18-292"><a href="#cb18-292"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"Not High"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"Missing"</span>))</span>
+<span id="cb18-293"><a href="#cb18-293"></a>  )</span>
+<span id="cb18-294"><a href="#cb18-294"></a></span>
+<span id="cb18-295"><a href="#cb18-295"></a>result <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-296"><a href="#cb18-296"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-297"><a href="#cb18-297"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-298"><a href="#cb18-298"></a>    <span class="st">"PARAM"</span>,</span>
+<span id="cb18-299"><a href="#cb18-299"></a>    <span class="at">split_fun =</span> drop_split_levels,</span>
+<span id="cb18-300"><a href="#cb18-300"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-301"><a href="#cb18-301"></a>    <span class="at">split_label =</span> <span class="st">"Parameter"</span></span>
+<span id="cb18-302"><a href="#cb18-302"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-303"><a href="#cb18-303"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb18-304"><a href="#cb18-304"></a>    <span class="st">"BTOXGR_GP"</span>,</span>
+<span id="cb18-305"><a href="#cb18-305"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb18-306"><a href="#cb18-306"></a>    <span class="at">split_label =</span> <span class="st">"    Baseline NCI-CTCAE Grade"</span>,</span>
+<span id="cb18-307"><a href="#cb18-307"></a>    <span class="at">indent_mod =</span> 2L</span>
+<span id="cb18-308"><a href="#cb18-308"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb18-309"><a href="#cb18-309"></a>  <span class="fu">summarize_num_patients</span>(<span class="at">var =</span> <span class="st">"USUBJID"</span>, <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique_count"</span>), <span class="at">unique_count_suffix =</span> <span class="cn">FALSE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-310"><a href="#cb18-310"></a>  <span class="fu">count_occurrences_by_grade</span>(<span class="st">"ATOXGR_GP"</span>, <span class="at">denom =</span> <span class="st">"n"</span>, <span class="at">drop =</span> <span class="cn">FALSE</span>, <span class="at">.indent_mods =</span> 3L) <span class="sc">%&gt;%</span></span>
+<span id="cb18-311"><a href="#cb18-311"></a>  <span class="fu">append_topleft</span>(<span class="st">"              Post-baseline NCI-CTCAE Grade"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb18-312"><a href="#cb18-312"></a>  <span class="fu">build_table</span>(<span class="at">df =</span> adlb_out, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb18-313"><a href="#cb18-313"></a></span>
+<span id="cb18-314"><a href="#cb18-314"></a>result</span>
+<span id="cb18-315"><a href="#cb18-315"></a><span class="in">```</span></span>
+<span id="cb18-316"><a href="#cb18-316"></a></span>
+<span id="cb18-317"><a href="#cb18-317"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb18-318"><a href="#cb18-318"></a></span>
+<span id="cb18-319"><a href="#cb18-319"></a><span class="fu">## `teal` App</span></span>
+<span id="cb18-320"><a href="#cb18-320"></a></span>
+<span id="cb18-321"><a href="#cb18-321"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb18-322"><a href="#cb18-322"></a><span class="co">#| screenshot.opts = list(delay = 16)</span></span>
+<span id="cb18-323"><a href="#cb18-323"></a></span>
+<span id="cb18-324"><a href="#cb18-324"></a><span class="fu">library</span>(scda)</span>
+<span id="cb18-325"><a href="#cb18-325"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb18-326"><a href="#cb18-326"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb18-327"><a href="#cb18-327"></a></span>
+<span id="cb18-328"><a href="#cb18-328"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb18-329"><a href="#cb18-329"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb18-330"><a href="#cb18-330"></a></span>
+<span id="cb18-331"><a href="#cb18-331"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb18-332"><a href="#cb18-332"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb18-333"><a href="#cb18-333"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb18-334"><a href="#cb18-334"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb,</span>
+<span id="cb18-335"><a href="#cb18-335"></a>      <span class="at">code =</span> <span class="st">'ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb")'</span></span>
+<span id="cb18-336"><a href="#cb18-336"></a>    ),</span>
+<span id="cb18-337"><a href="#cb18-337"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-338"><a href="#cb18-338"></a>  ),</span>
+<span id="cb18-339"><a href="#cb18-339"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb18-340"><a href="#cb18-340"></a>    <span class="fu">tm_t_shift_by_grade</span>(</span>
+<span id="cb18-341"><a href="#cb18-341"></a>      <span class="at">label =</span> <span class="st">"Grade Laboratory Abnormality Table"</span>,</span>
+<span id="cb18-342"><a href="#cb18-342"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb18-343"><a href="#cb18-343"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-344"><a href="#cb18-344"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb18-345"><a href="#cb18-345"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb18-346"><a href="#cb18-346"></a>      ),</span>
+<span id="cb18-347"><a href="#cb18-347"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-348"><a href="#cb18-348"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adlb, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb18-349"><a href="#cb18-349"></a>        <span class="at">selected =</span> <span class="st">"ALT"</span></span>
+<span id="cb18-350"><a href="#cb18-350"></a>      ),</span>
+<span id="cb18-351"><a href="#cb18-351"></a>      <span class="at">worst_flag_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-352"><a href="#cb18-352"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"WGRLOVFL"</span>, <span class="st">"WGRLOFL"</span>, <span class="st">"WGRHIVFL"</span>, <span class="st">"WGRHIFL"</span>)),</span>
+<span id="cb18-353"><a href="#cb18-353"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"WGRHIFL"</span>)</span>
+<span id="cb18-354"><a href="#cb18-354"></a>      ),</span>
+<span id="cb18-355"><a href="#cb18-355"></a>      <span class="at">worst_flag_indicator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-356"><a href="#cb18-356"></a>        <span class="fu">value_choices</span>(adlb, <span class="st">"WGRLOVFL"</span>),</span>
+<span id="cb18-357"><a href="#cb18-357"></a>        <span class="at">selected =</span> <span class="st">"Y"</span>, <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-358"><a href="#cb18-358"></a>      ),</span>
+<span id="cb18-359"><a href="#cb18-359"></a>      <span class="at">anl_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-360"><a href="#cb18-360"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>)),</span>
+<span id="cb18-361"><a href="#cb18-361"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"ATOXGR"</span>),</span>
+<span id="cb18-362"><a href="#cb18-362"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-363"><a href="#cb18-363"></a>      ),</span>
+<span id="cb18-364"><a href="#cb18-364"></a>      <span class="at">base_toxgrade_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb18-365"><a href="#cb18-365"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>)),</span>
+<span id="cb18-366"><a href="#cb18-366"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"BTOXGR"</span>),</span>
+<span id="cb18-367"><a href="#cb18-367"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb18-368"><a href="#cb18-368"></a>      ),</span>
+<span id="cb18-369"><a href="#cb18-369"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb18-370"><a href="#cb18-370"></a>    )</span>
+<span id="cb18-371"><a href="#cb18-371"></a>  ),</span>
+<span id="cb18-372"><a href="#cb18-372"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb18-373"><a href="#cb18-373"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb18-374"><a href="#cb18-374"></a>  )</span>
+<span id="cb18-375"><a href="#cb18-375"></a>)</span>
+<span id="cb18-376"><a href="#cb18-376"></a></span>
+<span id="cb18-377"><a href="#cb18-377"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb18-378"><a href="#cb18-378"></a><span class="in">```</span></span>
+<span id="cb18-379"><a href="#cb18-379"></a></span>
+<span id="cb18-380"><a href="#cb18-380"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb18-381"><a href="#cb18-381"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/lab-results/lbt15.html
@@ -0,0 +1,2370 @@
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - LBT15</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
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+pre.numberSource code > span > a:first-child::before
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+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="../../site_libs/quarto-search/fuse.min.js"></script>
+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/medical-history/mht01.html" rel="next">
+<link href="../../tables/lab-results/lbt14.html" rel="prev">
+<link href="../../assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="../../site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="../../site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="../../site_libs/quarto-html/quarto.js"></script>
+<script src="../../site_libs/quarto-html/popper.min.js"></script>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">LBT15</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Laboratory Test Shifts to NCI CTCAE Grade 3-4 Post-Baseline</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Modifying Cut Point</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>Because the <code>scda</code> dataset <code>adlb</code> doesn’t have the <code>PARCAT1</code> variable, this variable is created from <code>LBCAT</code> in pre-processing.</p>
+<p>adlb &lt;- adlb %&gt;%</p>
+<p>mutate(</p>
+<p>PARAM = with_label(.data$PARAM, “Laboratory Test”),</p>
+<p>ANRIND = with_label(.data$ANRIND, “Direction of Abnormality”)</p>
+<p>)</p>
+<div class="cell" data-hash="lbt15_cache/html/setup_ed3a6475e3dbbc80b102330d14cd2cef">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>    <span class="at">PARAM =</span> <span class="fu">with_label</span>(.data<span class="sc">$</span>PARAM, <span class="st">"Laboratory Test"</span>),</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    <span class="at">ANRIND =</span> <span class="fu">with_label</span>(.data<span class="sc">$</span>ANRIND, <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">PARCAT1 =</span> LBCAT</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>ATOXGR,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    ),</span>
+<span id="cb1-23"><a href="#cb1-23"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb1-24"><a href="#cb1-24"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb1-25"><a href="#cb1-25"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    ),</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    <span class="at">PARCAT1 =</span> LBCAT</span>
+<span id="cb1-29"><a href="#cb1-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a></span>
+<span id="cb1-33"><a href="#cb1-33"></a>adlb_alt_cut <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-35"><a href="#cb1-35"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>ATOXGR,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb1-39"><a href="#cb1-39"></a>    ),</span>
+<span id="cb1-40"><a href="#cb1-40"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb1-41"><a href="#cb1-41"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb1-42"><a href="#cb1-42"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb1-43"><a href="#cb1-43"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    )</span>
+<span id="cb1-45"><a href="#cb1-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb1-49"><a href="#cb1-49"></a>  <span class="at">PARCAT1 =</span> <span class="st">"Category for Lab Test"</span>,</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="at">PARAM =</span> <span class="st">"Parameter"</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="lbt15_cache/html/variant1_e0582fd664454b2447a5a08063df34fa">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Argument exclude_base_abn must be TRUE to include patients with normal or abnormal in the opposite direction in the denom</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a><span class="co"># So for "High" direction, subjects with baseline grade 3-4 are not in the denom.</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT1"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>PARCAT1)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">var =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">baseline =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">append_topleft</span>(<span class="st">"            Direction of Abnormality"</span>)</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Category for Lab Test                                                                                      
+  Parameter                                A: Drug X        B: Placebo     C: Combination    All Patients  
+            Direction of Abnormality        (N=134)          (N=134)          (N=132)           (N=400)    
+———————————————————————————————————————————————————————————————————————————————————————————————————————————
+CHEMISTRY                                                                                                  
+  Alanine Aminotransferase Measurement                                                                     
+            Low                          32/127 (25.2%)    32/128 (25%)     32/128 (25%)    96/383 (25.1%) 
+            High                             0/134            0/134            0/132             0/400     
+  C-Reactive Protein Measurement                                                                           
+            Low                          36/127 (28.3%)   36/127 (28.3%)   42/123 (34.1%)   114/377 (30.2%)
+            High                         34/124 (27.4%)   33/128 (25.8%)    31/129 (24%)    98/381 (25.7%) 
+IMMUNOLOGY                                                                                                 
+  Immunoglobulin A Measurement                                                                             
+            Low                              0/134            0/134            0/132             0/400     
+            High                         33/128 (25.8%)   32/124 (25.8%)   28/120 (23.3%)    93/372 (25%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="lbt15_cache/html/variant2_d9029e914b83ef7f3da3c9ecab679b9a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb_alt_cut, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-2"><a href="#cb4-2"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Category for Lab Test                                                                                      
+  Parameter                                A: Drug X        B: Placebo     C: Combination    All Patients  
+            Direction of Abnormality        (N=134)          (N=134)          (N=132)           (N=400)    
+———————————————————————————————————————————————————————————————————————————————————————————————————————————
+CHEMISTRY                                                                                                  
+  Alanine Aminotransferase Measurement                                                                     
+            Low                          46/119 (38.7%)   54/123 (43.9%)    47/127 (37%)    147/369 (39.8%)
+            High                             0/134            0/134            0/132             0/400     
+  C-Reactive Protein Measurement                                                                           
+            Low                          59/122 (48.4%)   56/118 (47.5%)   58/121 (47.9%)   173/361 (47.9%)
+            High                         54/122 (44.3%)   46/122 (37.7%)   44/122 (36.1%)   144/366 (39.3%)
+IMMUNOLOGY                                                                                                 
+  Immunoglobulin A Measurement                                                                             
+            Low                              0/134            0/134            0/132             0/400     
+            High                         47/124 (37.9%)    54/120 (45%)    47/115 (40.9%)   148/359 (41.2%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>The current module <code>tm_t_abnormality</code> is only displaying rows that are not all-zero, so the result could be a little different from static output where all-zero rows can be shown.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:12}" data-hash="lbt15_cache/html/teal_4fe1983170c607bbde4ef1b16c910774">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(ATOXGR,</span>
+<span id="cb6-9"><a href="#cb6-9"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb6-11"><a href="#cb6-11"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    ),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb6-15"><a href="#cb6-15"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    )</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-20"><a href="#cb6-20"></a>  <span class="fu">var_relabel</span>(<span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb6-21"><a href="#cb6-21"></a></span>
+<span id="cb6-22"><a href="#cb6-22"></a></span>
+<span id="cb6-23"><a href="#cb6-23"></a></span>
+<span id="cb6-24"><a href="#cb6-24"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-26"><a href="#cb6-26"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a><span class="st">                  ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb6-29"><a href="#cb6-29"></a><span class="st">                    mutate(</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a><span class="st">                      ANRIND = fct_collapse(ATOXGR,</span></span>
+<span id="cb6-31"><a href="#cb6-31"></a><span class="st">                                                "LOW" = c("-3", "-4"),</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a><span class="st">                                                "MODERATE/NORMAL" = c("-2", "-1", "0", "1", "2"),</span></span>
+<span id="cb6-33"><a href="#cb6-33"></a><span class="st">                                                "HIGH" = c("3", "4")</span></span>
+<span id="cb6-34"><a href="#cb6-34"></a><span class="st">                      ),</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a><span class="st">                      BNRIND = fct_collapse(BTOXGR,</span></span>
+<span id="cb6-36"><a href="#cb6-36"></a><span class="st">                                                "LOW" = c("-3", "-4"),</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a><span class="st">                                                "MODERATE/NORMAL" = c("-2", "-1", "0", "1", "2"),</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a><span class="st">                                                "HIGH" = c("3", "4")</span></span>
+<span id="cb6-39"><a href="#cb6-39"></a><span class="st">                      )</span></span>
+<span id="cb6-40"><a href="#cb6-40"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a><span class="st">                    filter(ONTRTFL == "Y") %&gt;%</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a><span class="st">                    var_relabel(ANRIND = "Direction of Abnormality")</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a><span class="st">                '</span>),</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-45"><a href="#cb6-45"></a>  ),</span>
+<span id="cb6-46"><a href="#cb6-46"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb6-48"><a href="#cb6-48"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb6-49"><a href="#cb6-49"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb6-50"><a href="#cb6-50"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-51"><a href="#cb6-51"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-52"><a href="#cb6-52"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a>      ),</span>
+<span id="cb6-54"><a href="#cb6-54"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-55"><a href="#cb6-55"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>)),</span>
+<span id="cb6-56"><a href="#cb6-56"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb6-57"><a href="#cb6-57"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a>      ),</span>
+<span id="cb6-59"><a href="#cb6-59"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-60"><a href="#cb6-60"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb6-61"><a href="#cb6-61"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb6-62"><a href="#cb6-62"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-63"><a href="#cb6-63"></a>      ),</span>
+<span id="cb6-64"><a href="#cb6-64"></a>      <span class="at">baseline_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-65"><a href="#cb6-65"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb6-66"><a href="#cb6-66"></a>        <span class="at">selected =</span> <span class="st">"BNRIND"</span>,</span>
+<span id="cb6-67"><a href="#cb6-67"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-68"><a href="#cb6-68"></a>      ),</span>
+<span id="cb6-69"><a href="#cb6-69"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb6-70"><a href="#cb6-70"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-71"><a href="#cb6-71"></a>    )</span>
+<span id="cb6-72"><a href="#cb6-72"></a>  )</span>
+<span id="cb6-73"><a href="#cb6-73"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:28:13.4481 pid:12289 token:[] teal.modules.clinical Initializing tm_t_abnormality</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="lbt15_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="lbt15_cache/html/sessioninfo_533aa5f41912a101ea8a146a13935d96">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] forcats_1.0.0                dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+[13] scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="lbt15_cache/html/snapshot_f245620d1880627dc2cca7e9608394b7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/lab-results/lbt15.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> LBT15</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Laboratory Test Shifts to NCI CTCAE Grade 3-4 Post-Baseline</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a>Because the <span class="in">`scda`</span> dataset <span class="in">`adlb`</span> doesn't have the <span class="in">`PARCAT1`</span> variable, this variable is created from <span class="in">`LBCAT`</span> in pre-processing.</span>
+<span id="cb12-14"><a href="#cb12-14"></a></span>
+<span id="cb12-15"><a href="#cb12-15"></a>adlb <span class="sc">\&lt;</span>- adlb %<span class="sc">\&gt;</span>%</span>
+<span id="cb12-16"><a href="#cb12-16"></a></span>
+<span id="cb12-17"><a href="#cb12-17"></a>mutate(</span>
+<span id="cb12-18"><a href="#cb12-18"></a></span>
+<span id="cb12-19"><a href="#cb12-19"></a>PARAM = with_label(.data\$PARAM, "Laboratory Test"),</span>
+<span id="cb12-20"><a href="#cb12-20"></a></span>
+<span id="cb12-21"><a href="#cb12-21"></a>ANRIND = with_label(.data\$ANRIND, "Direction of Abnormality")</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a>)</span>
+<span id="cb12-24"><a href="#cb12-24"></a></span>
+<span id="cb12-25"><a href="#cb12-25"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-26"><a href="#cb12-26"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-27"><a href="#cb12-27"></a></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-29"><a href="#cb12-29"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-30"><a href="#cb12-30"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-31"><a href="#cb12-31"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb12-32"><a href="#cb12-32"></a></span>
+<span id="cb12-33"><a href="#cb12-33"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-34"><a href="#cb12-34"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>)</span>
+<span id="cb12-35"><a href="#cb12-35"></a></span>
+<span id="cb12-36"><a href="#cb12-36"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-38"><a href="#cb12-38"></a>    <span class="at">PARAM =</span> <span class="fu">with_label</span>(.data<span class="sc">$</span>PARAM, <span class="st">"Laboratory Test"</span>),</span>
+<span id="cb12-39"><a href="#cb12-39"></a>    <span class="at">ANRIND =</span> <span class="fu">with_label</span>(.data<span class="sc">$</span>ANRIND, <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb12-40"><a href="#cb12-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-42"><a href="#cb12-42"></a>    <span class="at">PARCAT1 =</span> LBCAT</span>
+<span id="cb12-43"><a href="#cb12-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-45"><a href="#cb12-45"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>ATOXGR,</span>
+<span id="cb12-46"><a href="#cb12-46"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-47"><a href="#cb12-47"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb12-48"><a href="#cb12-48"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-49"><a href="#cb12-49"></a>    ),</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb12-51"><a href="#cb12-51"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-52"><a href="#cb12-52"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb12-53"><a href="#cb12-53"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-54"><a href="#cb12-54"></a>    ),</span>
+<span id="cb12-55"><a href="#cb12-55"></a>    <span class="at">PARCAT1 =</span> LBCAT</span>
+<span id="cb12-56"><a href="#cb12-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-57"><a href="#cb12-57"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a></span>
+<span id="cb12-60"><a href="#cb12-60"></a>adlb_alt_cut <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-62"><a href="#cb12-62"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>ATOXGR,</span>
+<span id="cb12-63"><a href="#cb12-63"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-64"><a href="#cb12-64"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb12-65"><a href="#cb12-65"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-66"><a href="#cb12-66"></a>    ),</span>
+<span id="cb12-67"><a href="#cb12-67"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb12-68"><a href="#cb12-68"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-69"><a href="#cb12-69"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>),</span>
+<span id="cb12-70"><a href="#cb12-70"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-71"><a href="#cb12-71"></a>    )</span>
+<span id="cb12-72"><a href="#cb12-72"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a>adlb <span class="ot">&lt;-</span> adlb <span class="sc">%&gt;%</span> <span class="fu">var_relabel</span>(</span>
+<span id="cb12-76"><a href="#cb12-76"></a>  <span class="at">PARCAT1 =</span> <span class="st">"Category for Lab Test"</span>,</span>
+<span id="cb12-77"><a href="#cb12-77"></a>  <span class="at">PARAM =</span> <span class="st">"Parameter"</span></span>
+<span id="cb12-78"><a href="#cb12-78"></a>)</span>
+<span id="cb12-79"><a href="#cb12-79"></a><span class="in">```</span></span>
+<span id="cb12-80"><a href="#cb12-80"></a></span>
+<span id="cb12-81"><a href="#cb12-81"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-82"><a href="#cb12-82"></a></span>
+<span id="cb12-83"><a href="#cb12-83"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-84"><a href="#cb12-84"></a><span class="co"># Argument exclude_base_abn must be TRUE to include patients with normal or abnormal in the opposite direction in the denom</span></span>
+<span id="cb12-85"><a href="#cb12-85"></a><span class="co"># So for "High" direction, subjects with baseline grade 3-4 are not in the denom.</span></span>
+<span id="cb12-86"><a href="#cb12-86"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-87"><a href="#cb12-87"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-88"><a href="#cb12-88"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARCAT1"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>PARCAT1)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-90"><a href="#cb12-90"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> drop_split_levels, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adlb<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-91"><a href="#cb12-91"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb12-92"><a href="#cb12-92"></a>    <span class="at">var =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-93"><a href="#cb12-93"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb12-94"><a href="#cb12-94"></a>    <span class="at">variables =</span> <span class="fu">list</span>(<span class="at">id =</span> <span class="st">"USUBJID"</span>, <span class="at">baseline =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb12-95"><a href="#cb12-95"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-96"><a href="#cb12-96"></a>    <span class="at">.indent_mods =</span> 4L</span>
+<span id="cb12-97"><a href="#cb12-97"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>  <span class="fu">append_topleft</span>(<span class="st">"            Direction of Abnormality"</span>)</span>
+<span id="cb12-99"><a href="#cb12-99"></a></span>
+<span id="cb12-100"><a href="#cb12-100"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-101"><a href="#cb12-101"></a>result</span>
+<span id="cb12-102"><a href="#cb12-102"></a><span class="in">```</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a></span>
+<span id="cb12-104"><a href="#cb12-104"></a><span class="fu">## Table Modifying Cut Point</span></span>
+<span id="cb12-105"><a href="#cb12-105"></a></span>
+<span id="cb12-106"><a href="#cb12-106"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-107"><a href="#cb12-107"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adlb_alt_cut, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-108"><a href="#cb12-108"></a>result</span>
+<span id="cb12-109"><a href="#cb12-109"></a><span class="in">```</span></span>
+<span id="cb12-110"><a href="#cb12-110"></a></span>
+<span id="cb12-111"><a href="#cb12-111"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-112"><a href="#cb12-112"></a></span>
+<span id="cb12-113"><a href="#cb12-113"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-114"><a href="#cb12-114"></a></span>
+<span id="cb12-115"><a href="#cb12-115"></a>The current module <span class="in">`tm_t_abnormality`</span> is only displaying rows that are not all-zero, so the result could be a little different from static output where all-zero rows can be shown.</span>
+<span id="cb12-116"><a href="#cb12-116"></a></span>
+<span id="cb12-117"><a href="#cb12-117"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="co">#| screenshot.opts = list(delay = 12)</span></span>
+<span id="cb12-119"><a href="#cb12-119"></a></span>
+<span id="cb12-120"><a href="#cb12-120"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-121"><a href="#cb12-121"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb12-122"><a href="#cb12-122"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-123"><a href="#cb12-123"></a></span>
+<span id="cb12-124"><a href="#cb12-124"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-125"><a href="#cb12-125"></a>adlb <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adlb"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-126"><a href="#cb12-126"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-127"><a href="#cb12-127"></a>    <span class="at">ANRIND =</span> <span class="fu">fct_collapse</span>(ATOXGR,</span>
+<span id="cb12-128"><a href="#cb12-128"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-129"><a href="#cb12-129"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb12-130"><a href="#cb12-130"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-131"><a href="#cb12-131"></a>    ),</span>
+<span id="cb12-132"><a href="#cb12-132"></a>    <span class="at">BNRIND =</span> <span class="fu">fct_collapse</span>(.data<span class="sc">$</span>BTOXGR,</span>
+<span id="cb12-133"><a href="#cb12-133"></a>      <span class="st">"LOW"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-3"</span>, <span class="st">"-4"</span>),</span>
+<span id="cb12-134"><a href="#cb12-134"></a>      <span class="st">"MODERATE/NORMAL"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"-2"</span>, <span class="st">"-1"</span>, <span class="st">"0"</span>, <span class="st">"1"</span>, <span class="st">"2"</span>),</span>
+<span id="cb12-135"><a href="#cb12-135"></a>      <span class="st">"HIGH"</span> <span class="ot">=</span> <span class="fu">c</span>(<span class="st">"3"</span>, <span class="st">"4"</span>)</span>
+<span id="cb12-136"><a href="#cb12-136"></a>    )</span>
+<span id="cb12-137"><a href="#cb12-137"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-138"><a href="#cb12-138"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-139"><a href="#cb12-139"></a>  <span class="fu">var_relabel</span>(<span class="at">ANRIND =</span> <span class="st">"Direction of Abnormality"</span>)</span>
+<span id="cb12-140"><a href="#cb12-140"></a></span>
+<span id="cb12-141"><a href="#cb12-141"></a></span>
+<span id="cb12-142"><a href="#cb12-142"></a></span>
+<span id="cb12-143"><a href="#cb12-143"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-144"><a href="#cb12-144"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-145"><a href="#cb12-145"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-146"><a href="#cb12-146"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADLB"</span>, adlb, <span class="at">code =</span> <span class="st">'</span></span>
+<span id="cb12-147"><a href="#cb12-147"></a><span class="st">                  ADLB &lt;- synthetic_cdisc_dataset("latest", "adlb") %&gt;%</span></span>
+<span id="cb12-148"><a href="#cb12-148"></a><span class="st">                    mutate(</span></span>
+<span id="cb12-149"><a href="#cb12-149"></a><span class="st">                      ANRIND = fct_collapse(ATOXGR,</span></span>
+<span id="cb12-150"><a href="#cb12-150"></a><span class="st">                                                "LOW" = c("-3", "-4"),</span></span>
+<span id="cb12-151"><a href="#cb12-151"></a><span class="st">                                                "MODERATE/NORMAL" = c("-2", "-1", "0", "1", "2"),</span></span>
+<span id="cb12-152"><a href="#cb12-152"></a><span class="st">                                                "HIGH" = c("3", "4")</span></span>
+<span id="cb12-153"><a href="#cb12-153"></a><span class="st">                      ),</span></span>
+<span id="cb12-154"><a href="#cb12-154"></a><span class="st">                      BNRIND = fct_collapse(BTOXGR,</span></span>
+<span id="cb12-155"><a href="#cb12-155"></a><span class="st">                                                "LOW" = c("-3", "-4"),</span></span>
+<span id="cb12-156"><a href="#cb12-156"></a><span class="st">                                                "MODERATE/NORMAL" = c("-2", "-1", "0", "1", "2"),</span></span>
+<span id="cb12-157"><a href="#cb12-157"></a><span class="st">                                                "HIGH" = c("3", "4")</span></span>
+<span id="cb12-158"><a href="#cb12-158"></a><span class="st">                      )</span></span>
+<span id="cb12-159"><a href="#cb12-159"></a><span class="st">                    ) %&gt;%</span></span>
+<span id="cb12-160"><a href="#cb12-160"></a><span class="st">                    filter(ONTRTFL == "Y") %&gt;%</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a><span class="st">                    var_relabel(ANRIND = "Direction of Abnormality")</span></span>
+<span id="cb12-162"><a href="#cb12-162"></a><span class="st">                '</span>),</span>
+<span id="cb12-163"><a href="#cb12-163"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-164"><a href="#cb12-164"></a>  ),</span>
+<span id="cb12-165"><a href="#cb12-165"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-166"><a href="#cb12-166"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb12-167"><a href="#cb12-167"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb12-168"><a href="#cb12-168"></a>      <span class="at">dataname =</span> <span class="st">"ADLB"</span>,</span>
+<span id="cb12-169"><a href="#cb12-169"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-170"><a href="#cb12-170"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-171"><a href="#cb12-171"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-172"><a href="#cb12-172"></a>      ),</span>
+<span id="cb12-173"><a href="#cb12-173"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-174"><a href="#cb12-174"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>)),</span>
+<span id="cb12-175"><a href="#cb12-175"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb12-176"><a href="#cb12-176"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a>      ),</span>
+<span id="cb12-178"><a href="#cb12-178"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-179"><a href="#cb12-179"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb12-180"><a href="#cb12-180"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-181"><a href="#cb12-181"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-182"><a href="#cb12-182"></a>      ),</span>
+<span id="cb12-183"><a href="#cb12-183"></a>      <span class="at">baseline_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-184"><a href="#cb12-184"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adlb, <span class="at">subset =</span> <span class="st">"BNRIND"</span>),</span>
+<span id="cb12-185"><a href="#cb12-185"></a>        <span class="at">selected =</span> <span class="st">"BNRIND"</span>,</span>
+<span id="cb12-186"><a href="#cb12-186"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-187"><a href="#cb12-187"></a>      ),</span>
+<span id="cb12-188"><a href="#cb12-188"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="st">"LOW"</span>, <span class="at">High =</span> <span class="st">"HIGH"</span>),</span>
+<span id="cb12-189"><a href="#cb12-189"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-190"><a href="#cb12-190"></a>    )</span>
+<span id="cb12-191"><a href="#cb12-191"></a>  )</span>
+<span id="cb12-192"><a href="#cb12-192"></a>)</span>
+<span id="cb12-193"><a href="#cb12-193"></a></span>
+<span id="cb12-194"><a href="#cb12-194"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-195"><a href="#cb12-195"></a><span class="in">```</span></span>
+<span id="cb12-196"><a href="#cb12-196"></a></span>
+<span id="cb12-197"><a href="#cb12-197"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-198"><a href="#cb12-198"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
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+  </div>
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+
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+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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new file mode 100644
index 0000000000..d26aac98ae
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+++ b/stable/tables/medical-history/mht01.html
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+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+  <i class="bi"></i>
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+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item">Tables</li><li class="breadcrumb-item"><a href="../../tables/medical-history/mht01.html">Medical History</a></li><li class="breadcrumb-item"><a href="../../tables/medical-history/mht01.html">MHT01</a></li></ol></nav>
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+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
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+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
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+ <span class="menu-text">Tables</span></a>
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
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+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="true">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
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+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">MHT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Medical History</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table of History <br> Prior to Study</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Total Number <br> of Conditions Suppressed</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table with Total Number of Conditions Per Body <br> System After The Summary of Patients</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table Showing Additional <br> “All Patients” Column</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="mht01_cache/html/setup_596260f002e62a7c05be0b2221bf3045">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>admh <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>admh <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(admh)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">select</span>(USUBJID, ACTARM)</span>
+<span id="cb1-15"><a href="#cb1-15"></a></span>
+<span id="cb1-16"><a href="#cb1-16"></a>admh_f <span class="ot">&lt;-</span> admh <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> MHBODSYS <span class="sc">!=</span> <span class="st">""</span> <span class="sc">&amp;</span> MHDECOD <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">MHBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">MHDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="mht01_cache/html/variant1_847c7f5069656bfb8b198f22f340f278">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>, <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>, <span class="st">"Total number of conditions"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-23"><a href="#cb2-23"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-24"><a href="#cb2-24"></a></span>
+<span id="cb2-25"><a href="#cb2-25"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-27"><a href="#cb2-27"></a></span>
+<span id="cb2-28"><a href="#cb2-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                 A: Drug X    B: Placebo    C: Combination
+  MedDRA Preferred Term                                    (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one condition     122 (91.0%)   123 (91.8%)    120 (90.9%)  
+Total number of conditions                                   609           622            703      
+cl A                                                                                               
+  Total number of patients with at least one condition   78 (58.2%)    75 (56.0%)      89 (67.4%)  
+  Total number of conditions                                 132           130            160      
+  trm A_1/2                                              50 (37.3%)    45 (33.6%)      63 (47.7%)  
+  trm A_2/2                                              48 (35.8%)    48 (35.8%)      50 (37.9%)  
+cl B                                                                                               
+  Total number of patients with at least one condition   96 (71.6%)    89 (66.4%)      97 (73.5%)  
+  Total number of conditions                                 185           198            205      
+  trm B_1/3                                              47 (35.1%)    49 (36.6%)      43 (32.6%)  
+  trm B_2/3                                              49 (36.6%)    44 (32.8%)      52 (39.4%)  
+  trm B_3/3                                              48 (35.8%)    54 (40.3%)      51 (38.6%)  
+cl C                                                                                               
+  Total number of patients with at least one condition   67 (50.0%)    75 (56.0%)      79 (59.8%)  
+  Total number of conditions                                 103           116            129      
+  trm C_1/2                                              43 (32.1%)    46 (34.3%)      43 (32.6%)  
+  trm C_2/2                                              35 (26.1%)    48 (35.8%)      55 (41.7%)  
+cl D                                                                                               
+  Total number of patients with at least one condition   96 (71.6%)    90 (67.2%)      98 (74.2%)  
+  Total number of conditions                                 189           178            209      
+  trm D_1/3                                              50 (37.3%)    42 (31.3%)      51 (38.6%)  
+  trm D_2/3                                              48 (35.8%)    42 (31.3%)      50 (37.9%)  
+  trm D_3/3                                              47 (35.1%)    58 (43.3%)      57 (43.2%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="mht01_cache/html/variant2_812e7aa0927148488921b4b82fd5bc00">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>admh_f_prior <span class="ot">&lt;-</span> admh_f <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">filter</span>(ASTDY <span class="sc">&lt;=</span> <span class="dv">0</span>)</span>
+<span id="cb4-3"><a href="#cb4-3"></a></span>
+<span id="cb4-4"><a href="#cb4-4"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f_prior, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb4-6"><a href="#cb4-6"></a></span>
+<span id="cb4-7"><a href="#cb4-7"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                A: Drug X   B: Placebo   C: Combination
+  MedDRA Preferred Term                                   (N=134)     (N=134)        (N=132)    
+————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one condition         0           0           1 (0.8%)   
+Total number of conditions                                   0           0              1       
+cl D                                                                                            
+  Total number of patients with at least one condition       0           0           1 (0.8%)   
+  Total number of conditions                                 0           0              1       
+  trm D_2/3                                                  0           0           1 (0.8%)   </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="mht01_cache/html/variant3_3552b890e10f4c12e9bec5e09d9d925c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb6-2"><a href="#cb6-2"></a></span>
+<span id="cb6-3"><a href="#cb6-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-7"><a href="#cb6-7"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb6-8"><a href="#cb6-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>)</span>
+<span id="cb6-9"><a href="#cb6-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-10"><a href="#cb6-10"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb6-11"><a href="#cb6-11"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb6-15"><a href="#cb6-15"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-16"><a href="#cb6-16"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb6-17"><a href="#cb6-17"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>),</span>
+<span id="cb6-20"><a href="#cb6-20"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-22"><a href="#cb6-22"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-23"><a href="#cb6-23"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb6-24"><a href="#cb6-24"></a></span>
+<span id="cb6-25"><a href="#cb6-25"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb6-27"><a href="#cb6-27"></a></span>
+<span id="cb6-28"><a href="#cb6-28"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                                 A: Drug X    B: Placebo    C: Combination
+  MedDRA Preferred Term                                    (N=134)       (N=134)        (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one condition     122 (91.0%)   123 (91.8%)    120 (90.9%)  
+cl A                                                                                               
+  Total number of patients with at least one condition   78 (58.2%)    75 (56.0%)      89 (67.4%)  
+  trm A_1/2                                              50 (37.3%)    45 (33.6%)      63 (47.7%)  
+  trm A_2/2                                              48 (35.8%)    48 (35.8%)      50 (37.9%)  
+cl B                                                                                               
+  Total number of patients with at least one condition   96 (71.6%)    89 (66.4%)      97 (73.5%)  
+  trm B_1/3                                              47 (35.1%)    49 (36.6%)      43 (32.6%)  
+  trm B_2/3                                              49 (36.6%)    44 (32.8%)      52 (39.4%)  
+  trm B_3/3                                              48 (35.8%)    54 (40.3%)      51 (38.6%)  
+cl C                                                                                               
+  Total number of patients with at least one condition   67 (50.0%)    75 (56.0%)      79 (59.8%)  
+  trm C_1/2                                              43 (32.1%)    46 (34.3%)      43 (32.6%)  
+  trm C_2/2                                              35 (26.1%)    48 (35.8%)      55 (41.7%)  
+cl D                                                                                               
+  Total number of patients with at least one condition   96 (71.6%)    90 (67.2%)      98 (74.2%)  
+  trm D_1/3                                              50 (37.3%)    42 (31.3%)      51 (38.6%)  
+  trm D_2/3                                              48 (35.8%)    42 (31.3%)      50 (37.9%)  
+  trm D_3/3                                              47 (35.1%)    58 (43.3%)      57 (43.2%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>Not currently supported by <code>rtables</code>. Users, please notify us if this variation is important to you.</p>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Conditions are further sorted by decreasing high level terms and low level terms.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="mht01_cache/html/variant4_954abb47b9479ab5c2fc1b3ce36ea4e7">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb8-2"><a href="#cb8-2"></a></span>
+<span id="cb8-3"><a href="#cb8-3"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-8"><a href="#cb8-8"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-9"><a href="#cb8-9"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one event"</span>, <span class="at">nonunique =</span> <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb8-10"><a href="#cb8-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-11"><a href="#cb8-11"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-12"><a href="#cb8-12"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb8-13"><a href="#cb8-13"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb8-17"><a href="#cb8-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-18"><a href="#cb8-18"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb8-19"><a href="#cb8-19"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-20"><a href="#cb8-20"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one event"</span>, <span class="at">nonunique =</span> <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb8-22"><a href="#cb8-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a>scorefun_hlt <span class="ot">&lt;-</span> cont_n_allcols</span>
+<span id="cb8-27"><a href="#cb8-27"></a>scorefun_llt <span class="ot">&lt;-</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">nlevels</span>(adsl_f<span class="sc">$</span>ACTARM) <span class="sc">+</span> <span class="dv">1</span>)</span>
+<span id="cb8-28"><a href="#cb8-28"></a></span>
+<span id="cb8-29"><a href="#cb8-29"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>), <span class="at">scorefun =</span> scorefun_hlt) <span class="sc">%&gt;%</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"MHDECOD"</span>), <span class="at">scorefun =</span> scorefun_llt)</span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>MedDRA System Organ Class                             A: Drug X    B: Placebo    C: Combination   All Patients
+  MedDRA Preferred Term                                (N=134)       (N=134)        (N=132)         (N=400)   
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total number of patients with at least one event     122 (91.0%)   123 (91.8%)    120 (90.9%)     365 (91.2%) 
+Total number of conditions                               609           622            703             1934    
+cl D                                                                                                          
+  Total number of patients with at least one event   96 (71.6%)    90 (67.2%)      98 (74.2%)     284 (71.0%) 
+  Total number of conditions                             189           178            209             576     
+  trm D_3/3                                          47 (35.1%)    58 (43.3%)      57 (43.2%)     162 (40.5%) 
+  trm D_1/3                                          50 (37.3%)    42 (31.3%)      51 (38.6%)     143 (35.8%) 
+  trm D_2/3                                          48 (35.8%)    42 (31.3%)      50 (37.9%)     140 (35.0%) 
+cl B                                                                                                          
+  Total number of patients with at least one event   96 (71.6%)    89 (66.4%)      97 (73.5%)     282 (70.5%) 
+  Total number of conditions                             185           198            205             588     
+  trm B_3/3                                          48 (35.8%)    54 (40.3%)      51 (38.6%)     153 (38.2%) 
+  trm B_2/3                                          49 (36.6%)    44 (32.8%)      52 (39.4%)     145 (36.2%) 
+  trm B_1/3                                          47 (35.1%)    49 (36.6%)      43 (32.6%)     139 (34.8%) 
+cl A                                                                                                          
+  Total number of patients with at least one event   78 (58.2%)    75 (56.0%)      89 (67.4%)     242 (60.5%) 
+  Total number of conditions                             132           130            160             422     
+  trm A_1/2                                          50 (37.3%)    45 (33.6%)      63 (47.7%)     158 (39.5%) 
+  trm A_2/2                                          48 (35.8%)    48 (35.8%)      50 (37.9%)     146 (36.5%) 
+cl C                                                                                                          
+  Total number of patients with at least one event   67 (50.0%)    75 (56.0%)      79 (59.8%)     221 (55.2%) 
+  Total number of conditions                             103           116            129             348     
+  trm C_2/2                                          35 (26.1%)    48 (35.8%)      55 (41.7%)     138 (34.5%) 
+  trm C_1/2                                          43 (32.1%)    46 (34.3%)      43 (32.6%)     132 (33.0%) </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="mht01_cache/html/teal_740ad80efcca0bb52fb0dd111add6141">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-3"><a href="#cb10-3"></a></span>
+<span id="cb10-4"><a href="#cb10-4"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-6"><a href="#cb10-6"></a>admh_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-7"><a href="#cb10-7"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> MHBODSYS <span class="sc">!=</span> <span class="st">""</span> <span class="sc">&amp;</span> MHDECOD <span class="sc">!=</span> <span class="st">""</span>)</span>
+<span id="cb10-8"><a href="#cb10-8"></a></span>
+<span id="cb10-9"><a href="#cb10-9"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-11"><a href="#cb10-11"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl_f, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a><span class="st">                  filter(SAFFL == "Y")'</span>),</span>
+<span id="cb10-13"><a href="#cb10-13"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADMH"</span>, admh_f, <span class="at">code =</span> <span class="st">'ADMH &lt;- synthetic_cdisc_dataset("latest", "admh") %&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="st">                  filter(SAFFL == "Y" &amp; MHBODSYS != "" &amp; MHDECOD != "")'</span>),</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-16"><a href="#cb10-16"></a>  ),</span>
+<span id="cb10-17"><a href="#cb10-17"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-18"><a href="#cb10-18"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb10-19"><a href="#cb10-19"></a>      <span class="at">label =</span> <span class="st">"Medical History Table"</span>,</span>
+<span id="cb10-20"><a href="#cb10-20"></a>      <span class="at">dataname =</span> <span class="st">"ADMH"</span>,</span>
+<span id="cb10-21"><a href="#cb10-21"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb10-22"><a href="#cb10-22"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-23"><a href="#cb10-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(admh_f, <span class="fu">c</span>(<span class="st">"MHTERM"</span>, <span class="st">"MHDECOD"</span>)),</span>
+<span id="cb10-24"><a href="#cb10-24"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"MHDECOD"</span>)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>      ),</span>
+<span id="cb10-26"><a href="#cb10-26"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-27"><a href="#cb10-27"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(admh_f, <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>, <span class="st">"MHSOC"</span>)),</span>
+<span id="cb10-28"><a href="#cb10-28"></a>        <span class="at">selected =</span> <span class="st">"MHBODSYS"</span></span>
+<span id="cb10-29"><a href="#cb10-29"></a>      ),</span>
+<span id="cb10-30"><a href="#cb10-30"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-31"><a href="#cb10-31"></a>      <span class="at">event_type =</span> <span class="st">"condition"</span></span>
+<span id="cb10-32"><a href="#cb10-32"></a>    )</span>
+<span id="cb10-33"><a href="#cb10-33"></a>  )</span>
+<span id="cb10-34"><a href="#cb10-34"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:14:18.5420 pid:10017 token:[] teal.modules.clinical Initializing tm_t_events</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="mht01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="mht01_cache/html/sessioninfo_229c2c927265ea35ea54210fb4c2228a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] scda_0.1.6                   dplyr_1.1.3                 
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="mht01_cache/html/snapshot_33cfe6de4f032f12a7352f54bc079f35">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/medical-history/mht01.lock">Download</a></p>
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> MHT01</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Medical History</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-19"><a href="#cb16-19"></a></span>
+<span id="cb16-20"><a href="#cb16-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-21"><a href="#cb16-21"></a>admh <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-25"><a href="#cb16-25"></a>admh <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(admh)</span>
+<span id="cb16-26"><a href="#cb16-26"></a></span>
+<span id="cb16-27"><a href="#cb16-27"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-28"><a href="#cb16-28"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-29"><a href="#cb16-29"></a>  <span class="fu">select</span>(USUBJID, ACTARM)</span>
+<span id="cb16-30"><a href="#cb16-30"></a></span>
+<span id="cb16-31"><a href="#cb16-31"></a>admh_f <span class="ot">&lt;-</span> admh <span class="sc">%&gt;%</span></span>
+<span id="cb16-32"><a href="#cb16-32"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> MHBODSYS <span class="sc">!=</span> <span class="st">""</span> <span class="sc">&amp;</span> MHDECOD <span class="sc">!=</span> <span class="st">""</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-33"><a href="#cb16-33"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb16-34"><a href="#cb16-34"></a>    <span class="at">MHBODSYS =</span> <span class="st">"MedDRA System Organ Class"</span>,</span>
+<span id="cb16-35"><a href="#cb16-35"></a>    <span class="at">MHDECOD =</span> <span class="st">"MedDRA Preferred Term"</span></span>
+<span id="cb16-36"><a href="#cb16-36"></a>  )</span>
+<span id="cb16-37"><a href="#cb16-37"></a><span class="in">```</span></span>
+<span id="cb16-38"><a href="#cb16-38"></a></span>
+<span id="cb16-39"><a href="#cb16-39"></a><span class="fu">## Standard Table</span></span>
+<span id="cb16-40"><a href="#cb16-40"></a></span>
+<span id="cb16-41"><a href="#cb16-41"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-42"><a href="#cb16-42"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-43"><a href="#cb16-43"></a></span>
+<span id="cb16-44"><a href="#cb16-44"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-45"><a href="#cb16-45"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-46"><a href="#cb16-46"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-47"><a href="#cb16-47"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-48"><a href="#cb16-48"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-49"><a href="#cb16-49"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>, <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb16-50"><a href="#cb16-50"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-51"><a href="#cb16-51"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-52"><a href="#cb16-52"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb16-53"><a href="#cb16-53"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-54"><a href="#cb16-54"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-55"><a href="#cb16-55"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb16-56"><a href="#cb16-56"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-57"><a href="#cb16-57"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-58"><a href="#cb16-58"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-59"><a href="#cb16-59"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-60"><a href="#cb16-60"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>, <span class="st">"Total number of conditions"</span>),</span>
+<span id="cb16-61"><a href="#cb16-61"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-62"><a href="#cb16-62"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-63"><a href="#cb16-63"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-64"><a href="#cb16-64"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-65"><a href="#cb16-65"></a></span>
+<span id="cb16-66"><a href="#cb16-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb16-67"><a href="#cb16-67"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-68"><a href="#cb16-68"></a></span>
+<span id="cb16-69"><a href="#cb16-69"></a>result</span>
+<span id="cb16-70"><a href="#cb16-70"></a><span class="in">```</span></span>
+<span id="cb16-71"><a href="#cb16-71"></a></span>
+<span id="cb16-72"><a href="#cb16-72"></a><span class="fu">## Table of History &lt;br/&gt; Prior to Study</span></span>
+<span id="cb16-73"><a href="#cb16-73"></a></span>
+<span id="cb16-74"><a href="#cb16-74"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>admh_f_prior <span class="ot">&lt;-</span> admh_f <span class="sc">%&gt;%</span></span>
+<span id="cb16-76"><a href="#cb16-76"></a>  <span class="fu">filter</span>(ASTDY <span class="sc">&lt;=</span> <span class="dv">0</span>)</span>
+<span id="cb16-77"><a href="#cb16-77"></a></span>
+<span id="cb16-78"><a href="#cb16-78"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f_prior, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb16-79"><a href="#cb16-79"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-80"><a href="#cb16-80"></a></span>
+<span id="cb16-81"><a href="#cb16-81"></a>result</span>
+<span id="cb16-82"><a href="#cb16-82"></a><span class="in">```</span></span>
+<span id="cb16-83"><a href="#cb16-83"></a></span>
+<span id="cb16-84"><a href="#cb16-84"></a><span class="fu">## Table with Total Number &lt;br/&gt; of Conditions Suppressed</span></span>
+<span id="cb16-85"><a href="#cb16-85"></a></span>
+<span id="cb16-86"><a href="#cb16-86"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-87"><a href="#cb16-87"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-88"><a href="#cb16-88"></a></span>
+<span id="cb16-89"><a href="#cb16-89"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-90"><a href="#cb16-90"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-91"><a href="#cb16-91"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-92"><a href="#cb16-92"></a>    <span class="at">vars =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-93"><a href="#cb16-93"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb16-94"><a href="#cb16-94"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>)</span>
+<span id="cb16-95"><a href="#cb16-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-96"><a href="#cb16-96"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-97"><a href="#cb16-97"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb16-98"><a href="#cb16-98"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-99"><a href="#cb16-99"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-100"><a href="#cb16-100"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb16-101"><a href="#cb16-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-102"><a href="#cb16-102"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-103"><a href="#cb16-103"></a>    <span class="at">var =</span> <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-104"><a href="#cb16-104"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>),</span>
+<span id="cb16-105"><a href="#cb16-105"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="st">"Total number of patients with at least one condition"</span>),</span>
+<span id="cb16-106"><a href="#cb16-106"></a>    <span class="at">show_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb16-107"><a href="#cb16-107"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-108"><a href="#cb16-108"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-110"><a href="#cb16-110"></a></span>
+<span id="cb16-111"><a href="#cb16-111"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-112"><a href="#cb16-112"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-113"><a href="#cb16-113"></a></span>
+<span id="cb16-114"><a href="#cb16-114"></a>result</span>
+<span id="cb16-115"><a href="#cb16-115"></a><span class="in">```</span></span>
+<span id="cb16-116"><a href="#cb16-116"></a></span>
+<span id="cb16-117"><a href="#cb16-117"></a><span class="fu">## Table with Total Number of Conditions Per Body &lt;br/&gt; System After The Summary of Patients</span></span>
+<span id="cb16-118"><a href="#cb16-118"></a></span>
+<span id="cb16-119"><a href="#cb16-119"></a>Not currently supported by <span class="in">`rtables`</span>.</span>
+<span id="cb16-120"><a href="#cb16-120"></a>Users, please notify us if this variation is important to you.</span>
+<span id="cb16-121"><a href="#cb16-121"></a></span>
+<span id="cb16-122"><a href="#cb16-122"></a><span class="fu">## Table Showing Additional &lt;br/&gt; "All Patients" Column</span></span>
+<span id="cb16-123"><a href="#cb16-123"></a></span>
+<span id="cb16-124"><a href="#cb16-124"></a>Conditions are further sorted by decreasing high level terms and low level terms.</span>
+<span id="cb16-125"><a href="#cb16-125"></a></span>
+<span id="cb16-126"><a href="#cb16-126"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-127"><a href="#cb16-127"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-128"><a href="#cb16-128"></a></span>
+<span id="cb16-129"><a href="#cb16-129"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-130"><a href="#cb16-130"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-131"><a href="#cb16-131"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-132"><a href="#cb16-132"></a>  <span class="fu">analyze_num_patients</span>(</span>
+<span id="cb16-133"><a href="#cb16-133"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-134"><a href="#cb16-134"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-135"><a href="#cb16-135"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one event"</span>, <span class="at">nonunique =</span> <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb16-136"><a href="#cb16-136"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-137"><a href="#cb16-137"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb16-138"><a href="#cb16-138"></a>    <span class="at">var =</span> <span class="st">"MHBODSYS"</span>,</span>
+<span id="cb16-139"><a href="#cb16-139"></a>    <span class="at">split_fun =</span> split_fun,</span>
+<span id="cb16-140"><a href="#cb16-140"></a>    <span class="at">child_labels =</span> <span class="st">"visible"</span>,</span>
+<span id="cb16-141"><a href="#cb16-141"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb16-142"><a href="#cb16-142"></a>    <span class="at">split_label =</span> <span class="fu">obj_label</span>(admh_f<span class="sc">$</span>MHBODSYS)</span>
+<span id="cb16-143"><a href="#cb16-143"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-144"><a href="#cb16-144"></a>  <span class="fu">summarize_num_patients</span>(</span>
+<span id="cb16-145"><a href="#cb16-145"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb16-146"><a href="#cb16-146"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"unique"</span>, <span class="st">"nonunique"</span>),</span>
+<span id="cb16-147"><a href="#cb16-147"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">unique =</span> <span class="st">"Total number of patients with at least one event"</span>, <span class="at">nonunique =</span> <span class="st">"Total number of conditions"</span>)</span>
+<span id="cb16-148"><a href="#cb16-148"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-149"><a href="#cb16-149"></a>  <span class="fu">count_occurrences</span>(<span class="at">vars =</span> <span class="st">"MHDECOD"</span>, <span class="at">.indent_mods =</span> <span class="sc">-</span>1L) <span class="sc">%&gt;%</span></span>
+<span id="cb16-150"><a href="#cb16-150"></a>  <span class="fu">append_varlabels</span>(admh_f, <span class="st">"MHDECOD"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb16-151"><a href="#cb16-151"></a></span>
+<span id="cb16-152"><a href="#cb16-152"></a>scorefun_hlt <span class="ot">&lt;-</span> cont_n_allcols</span>
+<span id="cb16-153"><a href="#cb16-153"></a>scorefun_llt <span class="ot">&lt;-</span> <span class="fu">score_occurrences_cols</span>(<span class="at">col_indices =</span> <span class="fu">nlevels</span>(adsl_f<span class="sc">$</span>ACTARM) <span class="sc">+</span> <span class="dv">1</span>)</span>
+<span id="cb16-154"><a href="#cb16-154"></a></span>
+<span id="cb16-155"><a href="#cb16-155"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, admh_f, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb16-156"><a href="#cb16-156"></a>  <span class="fu">prune_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-157"><a href="#cb16-157"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>), <span class="at">scorefun =</span> scorefun_hlt) <span class="sc">%&gt;%</span></span>
+<span id="cb16-158"><a href="#cb16-158"></a>  <span class="fu">sort_at_path</span>(<span class="at">path =</span> <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>, <span class="st">"*"</span>, <span class="st">"MHDECOD"</span>), <span class="at">scorefun =</span> scorefun_llt)</span>
+<span id="cb16-159"><a href="#cb16-159"></a></span>
+<span id="cb16-160"><a href="#cb16-160"></a>result</span>
+<span id="cb16-161"><a href="#cb16-161"></a><span class="in">```</span></span>
+<span id="cb16-162"><a href="#cb16-162"></a></span>
+<span id="cb16-163"><a href="#cb16-163"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-164"><a href="#cb16-164"></a></span>
+<span id="cb16-165"><a href="#cb16-165"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a></span>
+<span id="cb16-167"><a href="#cb16-167"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-168"><a href="#cb16-168"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb16-169"><a href="#cb16-169"></a></span>
+<span id="cb16-170"><a href="#cb16-170"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-171"><a href="#cb16-171"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-172"><a href="#cb16-172"></a></span>
+<span id="cb16-173"><a href="#cb16-173"></a>adsl_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb16-175"><a href="#cb16-175"></a>admh_f <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"admh"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-176"><a href="#cb16-176"></a>  <span class="fu">filter</span>(SAFFL <span class="sc">==</span> <span class="st">"Y"</span> <span class="sc">&amp;</span> MHBODSYS <span class="sc">!=</span> <span class="st">""</span> <span class="sc">&amp;</span> MHDECOD <span class="sc">!=</span> <span class="st">""</span>)</span>
+<span id="cb16-177"><a href="#cb16-177"></a></span>
+<span id="cb16-178"><a href="#cb16-178"></a>app <span class="ot">&lt;-</span> teal<span class="sc">::</span><span class="fu">init</span>(</span>
+<span id="cb16-179"><a href="#cb16-179"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-180"><a href="#cb16-180"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl_f, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl") %&gt;%</span></span>
+<span id="cb16-181"><a href="#cb16-181"></a><span class="st">                  filter(SAFFL == "Y")'</span>),</span>
+<span id="cb16-182"><a href="#cb16-182"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADMH"</span>, admh_f, <span class="at">code =</span> <span class="st">'ADMH &lt;- synthetic_cdisc_dataset("latest", "admh") %&gt;%</span></span>
+<span id="cb16-183"><a href="#cb16-183"></a><span class="st">                  filter(SAFFL == "Y" &amp; MHBODSYS != "" &amp; MHDECOD != "")'</span>),</span>
+<span id="cb16-184"><a href="#cb16-184"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-185"><a href="#cb16-185"></a>  ),</span>
+<span id="cb16-186"><a href="#cb16-186"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-187"><a href="#cb16-187"></a>    <span class="fu">tm_t_events</span>(</span>
+<span id="cb16-188"><a href="#cb16-188"></a>      <span class="at">label =</span> <span class="st">"Medical History Table"</span>,</span>
+<span id="cb16-189"><a href="#cb16-189"></a>      <span class="at">dataname =</span> <span class="st">"ADMH"</span>,</span>
+<span id="cb16-190"><a href="#cb16-190"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(<span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>), <span class="st">"ARM"</span>),</span>
+<span id="cb16-191"><a href="#cb16-191"></a>      <span class="at">llt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-192"><a href="#cb16-192"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(admh_f, <span class="fu">c</span>(<span class="st">"MHTERM"</span>, <span class="st">"MHDECOD"</span>)),</span>
+<span id="cb16-193"><a href="#cb16-193"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"MHDECOD"</span>)</span>
+<span id="cb16-194"><a href="#cb16-194"></a>      ),</span>
+<span id="cb16-195"><a href="#cb16-195"></a>      <span class="at">hlt =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-196"><a href="#cb16-196"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(admh_f, <span class="fu">c</span>(<span class="st">"MHBODSYS"</span>, <span class="st">"MHSOC"</span>)),</span>
+<span id="cb16-197"><a href="#cb16-197"></a>        <span class="at">selected =</span> <span class="st">"MHBODSYS"</span></span>
+<span id="cb16-198"><a href="#cb16-198"></a>      ),</span>
+<span id="cb16-199"><a href="#cb16-199"></a>      <span class="at">add_total =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb16-200"><a href="#cb16-200"></a>      <span class="at">event_type =</span> <span class="st">"condition"</span></span>
+<span id="cb16-201"><a href="#cb16-201"></a>    )</span>
+<span id="cb16-202"><a href="#cb16-202"></a>  )</span>
+<span id="cb16-203"><a href="#cb16-203"></a>)</span>
+<span id="cb16-204"><a href="#cb16-204"></a></span>
+<span id="cb16-205"><a href="#cb16-205"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-206"><a href="#cb16-206"></a><span class="in">```</span></span>
+<span id="cb16-207"><a href="#cb16-207"></a></span>
+<span id="cb16-208"><a href="#cb16-208"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-209"><a href="#cb16-209"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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\ No newline at end of file
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+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKCT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Summary Concentration Table</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkct01_cache/html/teal_f9356c89da1d96b00fa4bff7ebc8f093">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkct01_cache/html/sessioninfo_433aa331fedcaafb6788219ed06b474e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+loaded via a namespace (and not attached):
+ [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    
+ [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  
+ [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   
+[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    
+[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2</code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkct01_cache/html/snapshot_2cbce0c2d16eb68c48e651b528e6034f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-11"><a href="#cb4-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkct01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
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+        <span class="nav-page-text">PKPT02</span> <i class="bi bi-arrow-right-short"></i>
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb5" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb5-1"><a href="#cb5-1"></a><span class="co">---</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a><span class="an">title:</span><span class="co"> PKCT01</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a><span class="an">subtitle:</span><span class="co"> Summary Concentration Table</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a><span class="co">---</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a></span>
+<span id="cb5-6"><a href="#cb5-6"></a>------------------------------------------------------------------------</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb5-9"><a href="#cb5-9"></a></span>
+<span id="cb5-10"><a href="#cb5-10"></a>::: panel-tabset</span>
+<span id="cb5-11"><a href="#cb5-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a></span>
+<span id="cb5-13"><a href="#cb5-13"></a><span class="fu">## `teal` App</span></span>
+<span id="cb5-14"><a href="#cb5-14"></a></span>
+<span id="cb5-15"><a href="#cb5-15"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb5-16"><a href="#cb5-16"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb5-17"><a href="#cb5-17"></a></span>
+<span id="cb5-18"><a href="#cb5-18"></a><span class="co"># In progress</span></span>
+<span id="cb5-19"><a href="#cb5-19"></a><span class="in">```</span></span>
+<span id="cb5-20"><a href="#cb5-20"></a></span>
+<span id="cb5-21"><a href="#cb5-21"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb5-22"><a href="#cb5-22"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/pharmacokinetic/pkpt02.html b/stable/tables/pharmacokinetic/pkpt02.html
new file mode 100644
index 0000000000..24e7d6de54
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt02.html
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
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+</li>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">DMT01</span></a>
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+ <span class="menu-text">DISCLOSUREST01</span></a>
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+ <span class="menu-text">Disposition</span></a>
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+<li class="sidebar-item">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
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+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
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+</li>
+          <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary – Plasma/Serum/Blood PK Parameters (Stats in Rows)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table – Plasma</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt02_cache/html/setup_d63f9e433f4f4483f022461d018d6cd2">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="pkpt02_cache/html/unnamed-chunk-1_c5353e7f8c8d17bd49e4959289b07604">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    )</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="plasma-drug-x" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-x">Plasma Drug X</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt02_cache/html/variant1_dd068534feda94d2fb0a92b68d5cdab6">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb3-8"><a href="#cb3-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb3-10"><a href="#cb3-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Plasma PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————————————————————————————
+PK Parameter                     ARM A                   ARM C        
+——————————————————————————————————————————————————————————————————————
+Cmax (ug/mL)                                                          
+  n                               134                     132         
+  Mean (SD)              3.025e+01 (6.239e+00)   3.004e+01 (5.457e+00)
+  CV (%)                         20.6                    18.2         
+  Geometric Mean               2.961e+01               2.954e+01      
+  CV % Geometric Mean            21.0                    18.9         
+  Median                       2.986e+01               2.977e+01      
+  Min - Max              1.753e+01 - 4.871e+01   1.585e+01 - 4.757e+01
+AUCinf obs (day*ug/mL)                                                
+  n                               134                     132         
+  Mean (SD)              2.028e+02 (3.766e+01)   1.955e+02 (3.785e+01)
+  CV (%)                         18.6                    19.4         
+  Geometric Mean               1.994e+02               1.917e+02      
+  CV % Geometric Mean            18.7                    20.1         
+  Median                       1.971e+02               1.962e+02      
+  Min - Max              1.253e+02 - 3.110e+02   1.030e+02 - 3.145e+02
+CL obs (ml/day/kg)                                                    
+  n                               134                     132         
+  Mean (SD)              5.043e+00 (1.041e+00)   5.009e+00 (9.846e-01)
+  CV (%)                         20.6                    19.7         
+  Geometric Mean               4.929e+00               4.907e+00      
+  CV % Geometric Mean            22.4                    21.1         
+  Median                       5.078e+00               4.969e+00      
+  Min - Max              2.255e+00 - 7.395e+00   2.102e+00 - 7.489e+00</code></pre>
+</div>
+</div>
+</section><section id="plasma-drug-y" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-y">Plasma Drug Y</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="pkpt02_cache/html/variant2_cac84c225db681bad1b6278dacdced8e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb5-8"><a href="#cb5-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb5-10"><a href="#cb5-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Plasma PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug Y 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————
+PK Parameter                     ARM C        
+——————————————————————————————————————————————
+Cmax (ug/mL)                                  
+  n                               132         
+  Mean (SD)              2.990e+01 (5.550e+00)
+  CV (%)                         18.6         
+  Geometric Mean               2.935e+01      
+  CV % Geometric Mean            20.1         
+  Median                       2.969e+01      
+  Min - Max              1.406e+01 - 4.345e+01
+AUCinf obs (day*ug/mL)                        
+  n                               132         
+  Mean (SD)              1.986e+02 (3.792e+01)
+  CV (%)                         19.1         
+  Geometric Mean               1.952e+02      
+  CV % Geometric Mean            18.9         
+  Median                       1.953e+02      
+  Min - Max              1.264e+02 - 3.183e+02
+CL obs (ml/day/kg)                            
+  n                               132         
+  Mean (SD)              4.955e+00 (8.951e-01)
+  CV (%)                         18.1         
+  Geometric Mean               4.873e+00      
+  CV % Geometric Mean            18.7         
+  Median                       4.936e+00      
+  Min - Max              2.987e+00 - 7.211e+00</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt02_cache/html/teal_86eff185d8c7652d44a122f5d4c5c223">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt02_cache/html/sessioninfo_9f48db5d741b314278670cc810d58265">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      
+[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      
+[45] pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt02_cache/html/snapshot_9464e8da02d53c40184002c014cb1c64">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
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+          citeDiv.classList.add('hanging-indent');
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+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
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+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/pharmacokinetic/pkct01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKCT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt03.html" class="pagination-link">
+        <span class="nav-page-text">PKPT03</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> PKPT02</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary -- Plasma/Serum/Blood PK Parameters (Stats in Rows)</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-19"><a href="#cb11-19"></a></span>
+<span id="cb11-20"><a href="#cb11-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb11-21"><a href="#cb11-21"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Plasma"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a><span class="in">```</span></span>
+<span id="cb11-23"><a href="#cb11-23"></a></span>
+<span id="cb11-24"><a href="#cb11-24"></a><span class="fu">## Standard Table -- Plasma</span></span>
+<span id="cb11-25"><a href="#cb11-25"></a></span>
+<span id="cb11-28"><a href="#cb11-28"></a><span class="in">```{r}</span></span>
+<span id="cb11-29"><a href="#cb11-29"></a><span class="co"># lyt creation</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb11-32"><a href="#cb11-32"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb11-36"><a href="#cb11-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-38"><a href="#cb11-38"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb11-41"><a href="#cb11-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-42"><a href="#cb11-42"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb11-43"><a href="#cb11-43"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb11-44"><a href="#cb11-44"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-46"><a href="#cb11-46"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb11-47"><a href="#cb11-47"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb11-48"><a href="#cb11-48"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-49"><a href="#cb11-49"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-50"><a href="#cb11-50"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-51"><a href="#cb11-51"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-52"><a href="#cb11-52"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb11-53"><a href="#cb11-53"></a>    )</span>
+<span id="cb11-54"><a href="#cb11-54"></a>  )</span>
+<span id="cb11-55"><a href="#cb11-55"></a><span class="in">```</span></span>
+<span id="cb11-56"><a href="#cb11-56"></a></span>
+<span id="cb11-57"><a href="#cb11-57"></a><span class="fu">#### Plasma Drug X</span></span>
+<span id="cb11-58"><a href="#cb11-58"></a></span>
+<span id="cb11-59"><a href="#cb11-59"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-60"><a href="#cb11-60"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-61"><a href="#cb11-61"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-62"><a href="#cb11-62"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-63"><a href="#cb11-63"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-64"><a href="#cb11-64"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-65"><a href="#cb11-65"></a></span>
+<span id="cb11-66"><a href="#cb11-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb11-67"><a href="#cb11-67"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-68"><a href="#cb11-68"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-69"><a href="#cb11-69"></a>result</span>
+<span id="cb11-70"><a href="#cb11-70"></a><span class="in">```</span></span>
+<span id="cb11-71"><a href="#cb11-71"></a></span>
+<span id="cb11-72"><a href="#cb11-72"></a><span class="fu">#### Plasma Drug Y</span></span>
+<span id="cb11-73"><a href="#cb11-73"></a></span>
+<span id="cb11-74"><a href="#cb11-74"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb11-75"><a href="#cb11-75"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-76"><a href="#cb11-76"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-77"><a href="#cb11-77"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-78"><a href="#cb11-78"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-79"><a href="#cb11-79"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-80"><a href="#cb11-80"></a></span>
+<span id="cb11-81"><a href="#cb11-81"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb11-82"><a href="#cb11-82"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-83"><a href="#cb11-83"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-84"><a href="#cb11-84"></a>result</span>
+<span id="cb11-85"><a href="#cb11-85"></a><span class="in">```</span></span>
+<span id="cb11-86"><a href="#cb11-86"></a></span>
+<span id="cb11-87"><a href="#cb11-87"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-88"><a href="#cb11-88"></a></span>
+<span id="cb11-89"><a href="#cb11-89"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-90"><a href="#cb11-90"></a></span>
+<span id="cb11-91"><a href="#cb11-91"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-92"><a href="#cb11-92"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-93"><a href="#cb11-93"></a></span>
+<span id="cb11-94"><a href="#cb11-94"></a><span class="co"># In progress</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a><span class="in">```</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a></span>
+<span id="cb11-97"><a href="#cb11-97"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-98"><a href="#cb11-98"></a></span>
+<span id="cb11-99"><a href="#cb11-99"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/pharmacokinetic/pkpt03.html b/stable/tables/pharmacokinetic/pkpt03.html
new file mode 100644
index 0000000000..ba6f1641d5
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt03.html
@@ -0,0 +1,1960 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+div.sourceCode
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+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary of Plasma by Treatment (Stats in Columns)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt03_cache/html/teal_dea32e238a4a82c304efe08a6855041d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt03_cache/html/sessioninfo_113e7606fcb19ee4be3114fe71a3f16e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+loaded via a namespace (and not attached):
+ [1] digest_0.6.33     R6_2.5.1          codetools_0.2-19  fastmap_1.1.1    
+ [5] xfun_0.40         magrittr_2.0.3    knitr_1.44        htmltools_0.5.6  
+ [9] rmarkdown_2.25    cli_3.6.1         testthat_3.1.10   compiler_4.3.1   
+[13] rstudioapi_0.15.0 tools_4.3.1       brio_1.1.3        evaluate_0.21    
+[17] yaml_2.3.7        rlang_1.1.1       jsonlite_1.8.7    htmlwidgets_1.6.2</code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt03_cache/html/snapshot_f77cc3badcd842c4bc224080a2200a09">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-2"><a href="#cb4-2"></a></span>
+<span id="cb4-3"><a href="#cb4-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb4-4"><a href="#cb4-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb4-5"><a href="#cb4-5"></a></span>
+<span id="cb4-6"><a href="#cb4-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb4-9"><a href="#cb4-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb4-11"><a href="#cb4-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+      <a href="../../tables/pharmacokinetic/pkpt02.html" class="pagination-link">
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+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt04.html" class="pagination-link">
+        <span class="nav-page-text">PKPT04</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb5" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb5-1"><a href="#cb5-1"></a><span class="co">---</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a><span class="an">title:</span><span class="co"> PKPT03</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary of Plasma by Treatment (Stats in Columns)</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a><span class="co">---</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a></span>
+<span id="cb5-6"><a href="#cb5-6"></a>------------------------------------------------------------------------</span>
+<span id="cb5-7"><a href="#cb5-7"></a></span>
+<span id="cb5-8"><a href="#cb5-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb5-9"><a href="#cb5-9"></a></span>
+<span id="cb5-10"><a href="#cb5-10"></a>::: panel-tabset</span>
+<span id="cb5-11"><a href="#cb5-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb5-12"><a href="#cb5-12"></a></span>
+<span id="cb5-13"><a href="#cb5-13"></a></span>
+<span id="cb5-14"><a href="#cb5-14"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb5-15"><a href="#cb5-15"></a></span>
+<span id="cb5-16"><a href="#cb5-16"></a><span class="fu">## `teal` App</span></span>
+<span id="cb5-17"><a href="#cb5-17"></a></span>
+<span id="cb5-18"><a href="#cb5-18"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb5-19"><a href="#cb5-19"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb5-20"><a href="#cb5-20"></a></span>
+<span id="cb5-21"><a href="#cb5-21"></a><span class="co"># In progress</span></span>
+<span id="cb5-22"><a href="#cb5-22"></a><span class="in">```</span></span>
+<span id="cb5-23"><a href="#cb5-23"></a></span>
+<span id="cb5-24"><a href="#cb5-24"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb5-25"><a href="#cb5-25"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/tables/pharmacokinetic/pkpt04.html b/stable/tables/pharmacokinetic/pkpt04.html
new file mode 100644
index 0000000000..7a22e8dbca
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt04.html
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+div.sourceCode
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+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+ <span class="menu-text">AET06_SMQ</span></a>
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+ <span class="menu-text">AET07</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary – Urine PK Parameters (Stats in Rows)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt04_cache/html/setup_996696aa570f005c3837b0bcb4ce344e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Urine"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="pkpt04_cache/html/unnamed-chunk-1_d2d59ced25cc5c5773523397677ae14d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    )</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="plasma-drug-x" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-x">Plasma Drug X</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt04_cache/html/variant1_1622d12ef1013d7c18503f6d2f919507">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb3-8"><a href="#cb3-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb3-10"><a href="#cb3-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+—————————————————————————————————————————————————————————————————————
+PK Parameter                    ARM A                   ARM C        
+—————————————————————————————————————————————————————————————————————
+Ae (mg)                                                              
+  n                              268                     264         
+  Mean (SD)             1.551e+00 (3.385e-01)   1.535e+00 (2.978e-01)
+  CV (%)                        21.8                    19.4         
+  Geometric Mean              1.513e+00               1.505e+00      
+  CV % Geometric Mean           23.0                    20.3         
+  Median                      1.547e+00               1.547e+00      
+  Min - Max             7.021e-01 - 2.464e+00   8.502e-01 - 2.208e+00
+Fe (%)                                                               
+  n                              268                     264         
+  Mean (SD)             1.571e+01 (3.348e+00)   1.609e+01 (3.103e+00)
+  CV (%)                        21.3                    19.3         
+  Geometric Mean              1.534e+01               1.578e+01      
+  CV % Geometric Mean           22.2                    20.2         
+  Median                      1.577e+01               1.604e+01      
+  Min - Max             8.147e+00 - 2.452e+01   8.503e+00 - 2.443e+01
+CLR (L/hr)                                                           
+  n                              134                     132         
+  Mean (SD)             4.918e-02 (9.611e-03)   5.024e-02 (1.050e-02)
+  CV (%)                        19.5                    20.9         
+  Geometric Mean              4.818e-02               4.913e-02      
+  CV % Geometric Mean           21.0                    21.9         
+  Median                      4.909e-02               4.984e-02      
+  Min - Max             2.488e-02 - 7.511e-02   2.505e-02 - 8.560e-02
+RENALCLD (L/hr/mg)                                                   
+  n                              134                     132         
+  Mean (SD)             4.873e-03 (9.654e-04)   5.110e-03 (9.339e-04)
+  CV (%)                        19.8                    18.3         
+  Geometric Mean              4.772e-03               5.019e-03      
+  CV % Geometric Mean           21.2                    19.7         
+  Median                      4.967e-03               5.151e-03      
+  Min - Max             2.385e-03 - 7.258e-03   2.356e-03 - 7.407e-03</code></pre>
+</div>
+</div>
+</section><section id="plasma-drug-y" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-y">Plasma Drug Y</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="pkpt04_cache/html/variant2_73d0f4510ba846ad5b82f90e8a99e45f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb5-8"><a href="#cb5-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb5-10"><a href="#cb5-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug Y 
+Visit: CYCLE 1 DAY 1
+
+—————————————————————————————————————————————
+PK Parameter                    ARM C        
+—————————————————————————————————————————————
+Ae (mg)                                      
+  n                              264         
+  Mean (SD)             1.598e+00 (3.154e-01)
+  CV (%)                        19.7         
+  Geometric Mean              1.565e+00      
+  CV % Geometric Mean           21.4         
+  Median                      1.603e+00      
+  Min - Max             8.574e-01 - 2.257e+00
+Fe (%)                                       
+  n                              264         
+  Mean (SD)             1.583e+01 (3.077e+00)
+  CV (%)                        19.4         
+  Geometric Mean              1.552e+01      
+  CV % Geometric Mean           20.2         
+  Median                      1.570e+01      
+  Min - Max             8.311e+00 - 2.378e+01
+CLR (L/hr)                                   
+  n                              132         
+  Mean (SD)             4.966e-02 (1.009e-02)
+  CV (%)                        20.3         
+  Geometric Mean              4.857e-02      
+  CV % Geometric Mean           22.0         
+  Median                      4.912e-02      
+  Min - Max             1.839e-02 - 7.761e-02
+RENALCLD (L/hr/mg)                           
+  n                              132         
+  Mean (SD)             5.093e-03 (1.032e-03)
+  CV (%)                        20.3         
+  Geometric Mean              4.985e-03      
+  CV % Geometric Mean           21.4         
+  Median                      5.017e-03      
+  Min - Max             2.356e-03 - 7.939e-03</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt04_cache/html/teal_d3eb40e1a8dc83f3df7210f2f9a5ebcb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt04_cache/html/sessioninfo_f7ab00fe326d19db344d70971d3ee72a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      
+[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      
+[45] pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt04_cache/html/snapshot_311e7e717cf8151524b966626f173ecf">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
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+
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+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+        return popup.innerHTML;
+      });
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/pharmacokinetic/pkpt03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPT03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt05.html" class="pagination-link">
+        <span class="nav-page-text">PKPT05</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> PKPT04</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary -- Urine PK Parameters (Stats in Rows)</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-19"><a href="#cb11-19"></a></span>
+<span id="cb11-20"><a href="#cb11-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb11-21"><a href="#cb11-21"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Urine"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a><span class="in">```</span></span>
+<span id="cb11-23"><a href="#cb11-23"></a></span>
+<span id="cb11-24"><a href="#cb11-24"></a><span class="fu">## Standard Table</span></span>
+<span id="cb11-25"><a href="#cb11-25"></a></span>
+<span id="cb11-28"><a href="#cb11-28"></a><span class="in">```{r}</span></span>
+<span id="cb11-29"><a href="#cb11-29"></a><span class="co"># lyt creation</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb11-32"><a href="#cb11-32"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb11-36"><a href="#cb11-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-38"><a href="#cb11-38"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb11-41"><a href="#cb11-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-42"><a href="#cb11-42"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb11-43"><a href="#cb11-43"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb11-44"><a href="#cb11-44"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-46"><a href="#cb11-46"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb11-47"><a href="#cb11-47"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb11-48"><a href="#cb11-48"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-49"><a href="#cb11-49"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-50"><a href="#cb11-50"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-51"><a href="#cb11-51"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-52"><a href="#cb11-52"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb11-53"><a href="#cb11-53"></a>    )</span>
+<span id="cb11-54"><a href="#cb11-54"></a>  )</span>
+<span id="cb11-55"><a href="#cb11-55"></a><span class="in">```</span></span>
+<span id="cb11-56"><a href="#cb11-56"></a></span>
+<span id="cb11-57"><a href="#cb11-57"></a><span class="fu">#### Plasma Drug X</span></span>
+<span id="cb11-58"><a href="#cb11-58"></a></span>
+<span id="cb11-59"><a href="#cb11-59"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-60"><a href="#cb11-60"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-61"><a href="#cb11-61"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-62"><a href="#cb11-62"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-63"><a href="#cb11-63"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-64"><a href="#cb11-64"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-65"><a href="#cb11-65"></a></span>
+<span id="cb11-66"><a href="#cb11-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb11-67"><a href="#cb11-67"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-68"><a href="#cb11-68"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-69"><a href="#cb11-69"></a>result</span>
+<span id="cb11-70"><a href="#cb11-70"></a><span class="in">```</span></span>
+<span id="cb11-71"><a href="#cb11-71"></a></span>
+<span id="cb11-72"><a href="#cb11-72"></a><span class="fu">#### Plasma Drug Y</span></span>
+<span id="cb11-73"><a href="#cb11-73"></a></span>
+<span id="cb11-74"><a href="#cb11-74"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb11-75"><a href="#cb11-75"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-76"><a href="#cb11-76"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-77"><a href="#cb11-77"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-78"><a href="#cb11-78"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-79"><a href="#cb11-79"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-80"><a href="#cb11-80"></a></span>
+<span id="cb11-81"><a href="#cb11-81"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb11-82"><a href="#cb11-82"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-83"><a href="#cb11-83"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-84"><a href="#cb11-84"></a>result</span>
+<span id="cb11-85"><a href="#cb11-85"></a><span class="in">```</span></span>
+<span id="cb11-86"><a href="#cb11-86"></a></span>
+<span id="cb11-87"><a href="#cb11-87"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-88"><a href="#cb11-88"></a></span>
+<span id="cb11-89"><a href="#cb11-89"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-90"><a href="#cb11-90"></a></span>
+<span id="cb11-91"><a href="#cb11-91"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-92"><a href="#cb11-92"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-93"><a href="#cb11-93"></a></span>
+<span id="cb11-94"><a href="#cb11-94"></a><span class="co"># In progress</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a><span class="in">```</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a></span>
+<span id="cb11-97"><a href="#cb11-97"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-98"><a href="#cb11-98"></a></span>
+<span id="cb11-99"><a href="#cb11-99"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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diff --git a/stable/tables/pharmacokinetic/pkpt05.html b/stable/tables/pharmacokinetic/pkpt05.html
new file mode 100644
index 0000000000..c11fb87e26
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt05.html
@@ -0,0 +1,2181 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - PKPT05</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto"><div class="pt-lg-2 mt-2 text-left sidebar-header">
+      <a href="../../index.html" class="sidebar-logo-link">
+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT05</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Summary of Urinary PK Parameters by Treatment Arm (Stats in Columns)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt05_cache/html/setup_012039f0531069a91eec151025ac0f88">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Urine"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="pkpt05_cache/html/unnamed-chunk-1_4afece2a9a8462a0f05420695acbfbde">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>    ),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">geom_cv =</span> <span class="st">"CV % Geometric Mean"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>    ),</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-36"><a href="#cb2-36"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-37"><a href="#cb2-37"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-39"><a href="#cb2-39"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-40"><a href="#cb2-40"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-42"><a href="#cb2-42"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    )</span>
+<span id="cb2-44"><a href="#cb2-44"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="plasma-drug-x" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-x">Plasma Drug X</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt05_cache/html/variant1_a2de1693efde8b597985434d0d64e420">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb3-8"><a href="#cb3-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb3-10"><a href="#cb3-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Arm                                                                                                                         
+  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum 
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+ARM A                                                                                                                                 
+  Ae (mg)              268   1.551e+00   3.385e-01    21.8      1.513e+00             23.0           1.547e+00   7.021e-01   2.464e+00
+  Fe (%)               268   1.571e+01   3.348e+00    21.3      1.534e+01             22.2           1.577e+01   8.147e+00   2.452e+01
+  CLR (L/hr)           134   4.918e-02   9.611e-03    19.5      4.818e-02             21.0           4.909e-02   2.488e-02   7.511e-02
+  RENALCLD (L/hr/mg)   134   4.873e-03   9.654e-04    19.8      4.772e-03             21.2           4.967e-03   2.385e-03   7.258e-03
+ARM C                                                                                                                                 
+  Ae (mg)              264   1.535e+00   2.978e-01    19.4      1.505e+00             20.3           1.547e+00   8.502e-01   2.208e+00
+  Fe (%)               264   1.609e+01   3.103e+00    19.3      1.578e+01             20.2           1.604e+01   8.503e+00   2.443e+01
+  CLR (L/hr)           132   5.024e-02   1.050e-02    20.9      4.913e-02             21.9           4.984e-02   2.505e-02   8.560e-02
+  RENALCLD (L/hr/mg)   132   5.110e-03   9.339e-04    18.3      5.019e-03             19.7           5.151e-03   2.356e-03   7.407e-03</code></pre>
+</div>
+</div>
+</section><section id="plasma-drug-y" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-y">Plasma Drug Y</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="pkpt05_cache/html/variant2_06df104b2c3c201f9ff0fb7a55d6bae8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb5-8"><a href="#cb5-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb5-10"><a href="#cb5-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug Y 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Arm                                                                                                                         
+  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum 
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+ARM C                                                                                                                                 
+  Ae (mg)              264   1.598e+00   3.154e-01    19.7      1.565e+00             21.4           1.603e+00   8.574e-01   2.257e+00
+  Fe (%)               264   1.583e+01   3.077e+00    19.4      1.552e+01             20.2           1.570e+01   8.311e+00   2.378e+01
+  CLR (L/hr)           132   4.966e-02   1.009e-02    20.3      4.857e-02             22.0           4.912e-02   1.839e-02   7.761e-02
+  RENALCLD (L/hr/mg)   132   5.093e-03   1.032e-03    20.3      4.985e-03             21.4           5.017e-03   2.356e-03   7.939e-03</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt05_cache/html/teal_ff8779fa5aa39453183968f7e5343b0e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt05_cache/html/sessioninfo_9337826e4e496023ba121d1e9ca8d80c">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      
+[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      
+[45] pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt05_cache/html/snapshot_350a85a75225f08773013a67686eb961">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt05.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+        if (codeDiv.classList.contains(fromCls)) {
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+  }
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+  for (var i=0; i<noterefs.length; i++) {
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+    tippyHover(ref, function() {
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+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
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+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
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+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
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+              div.setAttribute("id", "code-annotation-line-highlight");
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
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+        return popup.innerHTML;
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+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/pharmacokinetic/pkpt04.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPT04</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt06.html" class="pagination-link">
+        <span class="nav-page-text">PKPT06</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> PKPT05</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Summary of Urinary PK Parameters by Treatment Arm (Stats in Columns)</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-19"><a href="#cb11-19"></a></span>
+<span id="cb11-20"><a href="#cb11-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb11-21"><a href="#cb11-21"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(PPSPEC <span class="sc">==</span> <span class="st">"Urine"</span>, AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a><span class="in">```</span></span>
+<span id="cb11-23"><a href="#cb11-23"></a></span>
+<span id="cb11-24"><a href="#cb11-24"></a><span class="fu">## Standard Table</span></span>
+<span id="cb11-25"><a href="#cb11-25"></a></span>
+<span id="cb11-28"><a href="#cb11-28"></a><span class="in">```{r}</span></span>
+<span id="cb11-29"><a href="#cb11-29"></a><span class="co"># lyt creation</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-32"><a href="#cb11-32"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb11-36"><a href="#cb11-36"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-38"><a href="#cb11-38"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span>,</span>
+<span id="cb11-41"><a href="#cb11-41"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb11-42"><a href="#cb11-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-43"><a href="#cb11-43"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb11-44"><a href="#cb11-44"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-46"><a href="#cb11-46"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb11-47"><a href="#cb11-47"></a>      <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>,</span>
+<span id="cb11-48"><a href="#cb11-48"></a>      <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb11-49"><a href="#cb11-49"></a>    ),</span>
+<span id="cb11-50"><a href="#cb11-50"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb11-51"><a href="#cb11-51"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb11-52"><a href="#cb11-52"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb11-53"><a href="#cb11-53"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb11-54"><a href="#cb11-54"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb11-55"><a href="#cb11-55"></a>      <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb11-56"><a href="#cb11-56"></a>      <span class="at">geom_cv =</span> <span class="st">"CV % Geometric Mean"</span>,</span>
+<span id="cb11-57"><a href="#cb11-57"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb11-58"><a href="#cb11-58"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb11-59"><a href="#cb11-59"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb11-60"><a href="#cb11-60"></a>    ),</span>
+<span id="cb11-61"><a href="#cb11-61"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-62"><a href="#cb11-62"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb11-63"><a href="#cb11-63"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-64"><a href="#cb11-64"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-65"><a href="#cb11-65"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-66"><a href="#cb11-66"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-67"><a href="#cb11-67"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-68"><a href="#cb11-68"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-69"><a href="#cb11-69"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-70"><a href="#cb11-70"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb11-71"><a href="#cb11-71"></a>    )</span>
+<span id="cb11-72"><a href="#cb11-72"></a>  )</span>
+<span id="cb11-73"><a href="#cb11-73"></a><span class="in">```</span></span>
+<span id="cb11-74"><a href="#cb11-74"></a></span>
+<span id="cb11-75"><a href="#cb11-75"></a><span class="fu">#### Plasma Drug X</span></span>
+<span id="cb11-76"><a href="#cb11-76"></a></span>
+<span id="cb11-77"><a href="#cb11-77"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-78"><a href="#cb11-78"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-79"><a href="#cb11-79"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-80"><a href="#cb11-80"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-81"><a href="#cb11-81"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-82"><a href="#cb11-82"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-83"><a href="#cb11-83"></a></span>
+<span id="cb11-84"><a href="#cb11-84"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb11-85"><a href="#cb11-85"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-86"><a href="#cb11-86"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-87"><a href="#cb11-87"></a>result</span>
+<span id="cb11-88"><a href="#cb11-88"></a><span class="in">```</span></span>
+<span id="cb11-89"><a href="#cb11-89"></a></span>
+<span id="cb11-90"><a href="#cb11-90"></a><span class="fu">#### Plasma Drug Y</span></span>
+<span id="cb11-91"><a href="#cb11-91"></a></span>
+<span id="cb11-92"><a href="#cb11-92"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb11-93"><a href="#cb11-93"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-94"><a href="#cb11-94"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-97"><a href="#cb11-97"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-98"><a href="#cb11-98"></a></span>
+<span id="cb11-99"><a href="#cb11-99"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb11-100"><a href="#cb11-100"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-101"><a href="#cb11-101"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-102"><a href="#cb11-102"></a>result</span>
+<span id="cb11-103"><a href="#cb11-103"></a><span class="in">```</span></span>
+<span id="cb11-104"><a href="#cb11-104"></a></span>
+<span id="cb11-105"><a href="#cb11-105"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-106"><a href="#cb11-106"></a></span>
+<span id="cb11-107"><a href="#cb11-107"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-108"><a href="#cb11-108"></a></span>
+<span id="cb11-109"><a href="#cb11-109"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-110"><a href="#cb11-110"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-111"><a href="#cb11-111"></a></span>
+<span id="cb11-112"><a href="#cb11-112"></a><span class="co"># In progress</span></span>
+<span id="cb11-113"><a href="#cb11-113"></a><span class="in">```</span></span>
+<span id="cb11-114"><a href="#cb11-114"></a></span>
+<span id="cb11-115"><a href="#cb11-115"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-116"><a href="#cb11-116"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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\ No newline at end of file
diff --git a/stable/tables/pharmacokinetic/pkpt06.html b/stable/tables/pharmacokinetic/pkpt06.html
new file mode 100644
index 0000000000..cf7bd31f49
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt06.html
@@ -0,0 +1,2147 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+<style>
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+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
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+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
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+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "copy-button": true,
+  "collapse-after": 3,
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+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
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+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
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+      </div> <!-- /container-fluid -->
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+    <div class="sidebar-menu-container"> 
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
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+ <span class="menu-text">ADA</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT06</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary – Dose-Normalized PK Parameters (Stats in Rows)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt06_cache/html/setup_017a4b85b0386a096d2547e931310f27">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, <span class="fu">str_detect</span>(<span class="fu">tolower</span>(PARAM), <span class="fu">regex</span>(<span class="st">"norm by dose"</span>, <span class="at">ignore_case =</span> <span class="cn">TRUE</span>)))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="pkpt06_cache/html/unnamed-chunk-1_f806b664f711e97667d915845a3516e3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    )</span>
+<span id="cb2-26"><a href="#cb2-26"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="plasma-drug-x" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-x">Plasma Drug X</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt06_cache/html/variant1_24f54cd66948638a0b7f9eba71bf6033">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb3-8"><a href="#cb3-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb3-10"><a href="#cb3-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+—————————————————————————————————————————————————————————————————————
+PK Parameter                    ARM A                   ARM C        
+—————————————————————————————————————————————————————————————————————
+RENALCLD (L/hr/mg)                                                   
+  n                              134                     132         
+  Mean (SD)             4.873e-03 (9.654e-04)   5.110e-03 (9.339e-04)
+  CV (%)                        19.8                    18.3         
+  Geometric Mean              4.772e-03               5.019e-03      
+  CV % Geometric Mean           21.2                    19.7         
+  Median                      4.967e-03               5.151e-03      
+  Min - Max             2.385e-03 - 7.258e-03   2.356e-03 - 7.407e-03</code></pre>
+</div>
+</div>
+</section><section id="plasma-drug-y" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-y">Plasma Drug Y</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="pkpt06_cache/html/variant2_723e2844e786003b788ec691225e6029">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb5-8"><a href="#cb5-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb5-10"><a href="#cb5-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug Y 
+Visit: CYCLE 1 DAY 1
+
+—————————————————————————————————————————————
+PK Parameter                    ARM C        
+—————————————————————————————————————————————
+RENALCLD (L/hr/mg)                           
+  n                              132         
+  Mean (SD)             5.093e-03 (1.032e-03)
+  CV (%)                        20.3         
+  Geometric Mean              4.985e-03      
+  CV % Geometric Mean           21.4         
+  Median                      5.017e-03      
+  Min - Max             2.356e-03 - 7.939e-03</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt06_cache/html/teal_a52db47fddd0bb6715b3aa3c7e686267">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt06_cache/html/sessioninfo_61c9051dfe7970da473cee74fa4242a7">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] stringr_1.5.0    tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   stringi_1.7.12    broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt06_cache/html/snapshot_8ec00efa1e042e085cb8d557ad7e9c75">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt06.lock">Download</a></p>
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+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/pharmacokinetic/pkpt05.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPT05</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt07.html" class="pagination-link">
+        <span class="nav-page-text">PKPT07</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> PKPT06</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary -- Dose-Normalized PK Parameters (Stats in Rows)</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-19"><a href="#cb11-19"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb11-20"><a href="#cb11-20"></a></span>
+<span id="cb11-21"><a href="#cb11-21"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, <span class="fu">str_detect</span>(<span class="fu">tolower</span>(PARAM), <span class="fu">regex</span>(<span class="st">"norm by dose"</span>, <span class="at">ignore_case =</span> <span class="cn">TRUE</span>)))</span>
+<span id="cb11-23"><a href="#cb11-23"></a><span class="in">```</span></span>
+<span id="cb11-24"><a href="#cb11-24"></a></span>
+<span id="cb11-25"><a href="#cb11-25"></a><span class="fu">## Standard Table</span></span>
+<span id="cb11-26"><a href="#cb11-26"></a></span>
+<span id="cb11-29"><a href="#cb11-29"></a><span class="in">```{r}</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a><span class="co"># lyt creation</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-32"><a href="#cb11-32"></a>  <span class="fu">split_cols_by</span>(</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="co"># label_pos = "topleft",</span></span>
+<span id="cb11-36"><a href="#cb11-36"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-41"><a href="#cb11-41"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb11-42"><a href="#cb11-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-43"><a href="#cb11-43"></a>  tern<span class="sc">::</span><span class="fu">analyze_vars</span>(</span>
+<span id="cb11-44"><a href="#cb11-44"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"mean_sd"</span>, <span class="st">"cv"</span>, <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>, <span class="st">"range"</span>),</span>
+<span id="cb11-46"><a href="#cb11-46"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-47"><a href="#cb11-47"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb11-48"><a href="#cb11-48"></a>      <span class="at">mean_sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e (%.3e)"</span>),</span>
+<span id="cb11-49"><a href="#cb11-49"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-50"><a href="#cb11-50"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-51"><a href="#cb11-51"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-52"><a href="#cb11-52"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-53"><a href="#cb11-53"></a>      <span class="at">range =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e - %.3e"</span>)</span>
+<span id="cb11-54"><a href="#cb11-54"></a>    )</span>
+<span id="cb11-55"><a href="#cb11-55"></a>  )</span>
+<span id="cb11-56"><a href="#cb11-56"></a><span class="in">```</span></span>
+<span id="cb11-57"><a href="#cb11-57"></a></span>
+<span id="cb11-58"><a href="#cb11-58"></a><span class="fu">#### Plasma Drug X</span></span>
+<span id="cb11-59"><a href="#cb11-59"></a></span>
+<span id="cb11-60"><a href="#cb11-60"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-61"><a href="#cb11-61"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-62"><a href="#cb11-62"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-63"><a href="#cb11-63"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-64"><a href="#cb11-64"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-65"><a href="#cb11-65"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-66"><a href="#cb11-66"></a></span>
+<span id="cb11-67"><a href="#cb11-67"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb11-68"><a href="#cb11-68"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-69"><a href="#cb11-69"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-70"><a href="#cb11-70"></a>result</span>
+<span id="cb11-71"><a href="#cb11-71"></a><span class="in">```</span></span>
+<span id="cb11-72"><a href="#cb11-72"></a></span>
+<span id="cb11-73"><a href="#cb11-73"></a><span class="fu">#### Plasma Drug Y</span></span>
+<span id="cb11-74"><a href="#cb11-74"></a></span>
+<span id="cb11-75"><a href="#cb11-75"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb11-76"><a href="#cb11-76"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-77"><a href="#cb11-77"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-78"><a href="#cb11-78"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-79"><a href="#cb11-79"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-80"><a href="#cb11-80"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-81"><a href="#cb11-81"></a></span>
+<span id="cb11-82"><a href="#cb11-82"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb11-83"><a href="#cb11-83"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of Dose-Normalized PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-84"><a href="#cb11-84"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-85"><a href="#cb11-85"></a>result</span>
+<span id="cb11-86"><a href="#cb11-86"></a><span class="in">```</span></span>
+<span id="cb11-87"><a href="#cb11-87"></a></span>
+<span id="cb11-88"><a href="#cb11-88"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-89"><a href="#cb11-89"></a></span>
+<span id="cb11-90"><a href="#cb11-90"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-91"><a href="#cb11-91"></a></span>
+<span id="cb11-92"><a href="#cb11-92"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-93"><a href="#cb11-93"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-94"><a href="#cb11-94"></a></span>
+<span id="cb11-95"><a href="#cb11-95"></a><span class="co"># In progress</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a><span class="in">```</span></span>
+<span id="cb11-97"><a href="#cb11-97"></a></span>
+<span id="cb11-98"><a href="#cb11-98"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-99"><a href="#cb11-99"></a></span>
+<span id="cb11-100"><a href="#cb11-100"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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diff --git a/stable/tables/pharmacokinetic/pkpt07.html b/stable/tables/pharmacokinetic/pkpt07.html
new file mode 100644
index 0000000000..dab5430110
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt07.html
@@ -0,0 +1,2174 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
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+.sourceCode { overflow: visible; }
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+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
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+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT07</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Table of Mean Dose-Normalized Selected Pharmacokinetic Parameters (Stats in Columns)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table – Urine</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt07_cache/html/setup_3fb50bf0ea2171719d96639b76cbb4be">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, <span class="fu">str_detect</span>(<span class="fu">tolower</span>(PARAM), <span class="fu">regex</span>(<span class="st">"norm by dose"</span>, <span class="at">ignore_case =</span> <span class="cn">TRUE</span>)))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-hash="pkpt07_cache/html/unnamed-chunk-1_dfae9276a236f6d5ccec26f75522df2f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># lyt creation</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb2-21"><a href="#cb2-21"></a>    ),</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb2-26"><a href="#cb2-26"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">geom_cv =</span> <span class="st">"CV % Geometric Mean"</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb2-30"><a href="#cb2-30"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb2-31"><a href="#cb2-31"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>    ),</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-34"><a href="#cb2-34"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-35"><a href="#cb2-35"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-36"><a href="#cb2-36"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-37"><a href="#cb2-37"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-39"><a href="#cb2-39"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-40"><a href="#cb2-40"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-42"><a href="#cb2-42"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb2-43"><a href="#cb2-43"></a>    )</span>
+<span id="cb2-44"><a href="#cb2-44"></a>  )</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<section id="plasma-drug-x" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-x">Plasma Drug X</h4>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt07_cache/html/variant1_a700ea77258574ac4f272f1a0665f0d2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb3"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb3-1"><a href="#cb3-1"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb3-2"><a href="#cb3-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb3-3"><a href="#cb3-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb3-4"><a href="#cb3-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb3-5"><a href="#cb3-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb3-6"><a href="#cb3-6"></a></span>
+<span id="cb3-7"><a href="#cb3-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb3-8"><a href="#cb3-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb3-9"><a href="#cb3-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb3-10"><a href="#cb3-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Arm                                                                                                                         
+  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum 
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+ARM A                                                                                                                                 
+  RENALCLD (L/hr/mg)   134   4.873e-03   9.654e-04    19.8      4.772e-03             21.2           4.967e-03   2.385e-03   7.258e-03
+ARM C                                                                                                                                 
+  RENALCLD (L/hr/mg)   132   5.110e-03   9.339e-04    18.3      5.019e-03             19.7           5.151e-03   2.356e-03   7.407e-03</code></pre>
+</div>
+</div>
+</section><section id="plasma-drug-y" class="level4"><h4 class="anchored" data-anchor-id="plasma-drug-y">Plasma Drug Y</h4>
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="pkpt07_cache/html/variant2_da413b8daa6792d21d5d490635eb4426">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb5-2"><a href="#cb5-2"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb5-3"><a href="#cb5-3"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb5-4"><a href="#cb5-4"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb5-5"><a href="#cb5-5"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb5-6"><a href="#cb5-6"></a></span>
+<span id="cb5-7"><a href="#cb5-7"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb5-8"><a href="#cb5-8"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb5-9"><a href="#cb5-9"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb5-10"><a href="#cb5-10"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Urine PK Parameter by Treatment Arm, PK Population
+Analyte: Plasma Drug Y 
+Visit: CYCLE 1 DAY 1
+
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Treatment Arm                                                                                                                         
+  PK Parameter          n      Mean         SD       CV (%)   Geometric Mean   CV % Geometric Mean    Median      Minimum     Maximum 
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+ARM C                                                                                                                                 
+  RENALCLD (L/hr/mg)   132   5.093e-03   1.032e-03    20.3      4.985e-03             21.4           5.017e-03   2.356e-03   7.939e-03</code></pre>
+</div>
+</div>
+</section>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt07_cache/html/teal_95a9b3f73a2bdcc8af344f1ea86860d8">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt07_cache/html/sessioninfo_ee20f53dc80609a59c125d721d542093">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] stringr_1.5.0    tern_0.9.0       rtables_0.6.3    magrittr_2.0.3  
+[5] formatters_0.5.2 dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   stringi_1.7.12    broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt07_cache/html/snapshot_e5acdecc9049303927fe358a3ace35d1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-2"><a href="#cb10-2"></a></span>
+<span id="cb10-3"><a href="#cb10-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb10-9"><a href="#cb10-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb10-10"><a href="#cb10-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-11"><a href="#cb10-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt07.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+        return {
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+          cites: cites.split(' ')
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+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    if (citeInfo) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/pharmacokinetic/pkpt06.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPT06</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt08.html" class="pagination-link">
+        <span class="nav-page-text">PKPT08</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb11" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb11-1"><a href="#cb11-1"></a><span class="co">---</span></span>
+<span id="cb11-2"><a href="#cb11-2"></a><span class="an">title:</span><span class="co"> PKPT07</span></span>
+<span id="cb11-3"><a href="#cb11-3"></a><span class="an">subtitle:</span><span class="co"> Table of Mean Dose-Normalized Selected Pharmacokinetic Parameters (Stats in Columns)</span></span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="co">---</span></span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>------------------------------------------------------------------------</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb11-9"><a href="#cb11-9"></a></span>
+<span id="cb11-10"><a href="#cb11-10"></a>::: panel-tabset</span>
+<span id="cb11-11"><a href="#cb11-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb11-12"><a href="#cb11-12"></a></span>
+<span id="cb11-13"><a href="#cb11-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb11-14"><a href="#cb11-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-15"><a href="#cb11-15"></a></span>
+<span id="cb11-16"><a href="#cb11-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb11-17"><a href="#cb11-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb11-18"><a href="#cb11-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb11-19"><a href="#cb11-19"></a><span class="fu">library</span>(stringr)</span>
+<span id="cb11-20"><a href="#cb11-20"></a></span>
+<span id="cb11-21"><a href="#cb11-21"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb11-22"><a href="#cb11-22"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span> <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>, <span class="fu">str_detect</span>(<span class="fu">tolower</span>(PARAM), <span class="fu">regex</span>(<span class="st">"norm by dose"</span>, <span class="at">ignore_case =</span> <span class="cn">TRUE</span>)))</span>
+<span id="cb11-23"><a href="#cb11-23"></a><span class="in">```</span></span>
+<span id="cb11-24"><a href="#cb11-24"></a></span>
+<span id="cb11-25"><a href="#cb11-25"></a><span class="fu">## Standard Table -- Urine</span></span>
+<span id="cb11-26"><a href="#cb11-26"></a></span>
+<span id="cb11-29"><a href="#cb11-29"></a><span class="in">```{r}</span></span>
+<span id="cb11-30"><a href="#cb11-30"></a><span class="co"># lyt creation</span></span>
+<span id="cb11-31"><a href="#cb11-31"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-32"><a href="#cb11-32"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-33"><a href="#cb11-33"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb11-34"><a href="#cb11-34"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ARMCD"</span>),</span>
+<span id="cb11-35"><a href="#cb11-35"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-36"><a href="#cb11-36"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb11-37"><a href="#cb11-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-38"><a href="#cb11-38"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb11-39"><a href="#cb11-39"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb11-40"><a href="#cb11-40"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb11-41"><a href="#cb11-41"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span>,</span>
+<span id="cb11-42"><a href="#cb11-42"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb11-43"><a href="#cb11-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb11-44"><a href="#cb11-44"></a>  <span class="fu">analyze_vars_in_cols</span>(</span>
+<span id="cb11-45"><a href="#cb11-45"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb11-46"><a href="#cb11-46"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-47"><a href="#cb11-47"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb11-48"><a href="#cb11-48"></a>      <span class="st">"geom_mean"</span>, <span class="st">"geom_cv"</span>, <span class="st">"median"</span>,</span>
+<span id="cb11-49"><a href="#cb11-49"></a>      <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb11-50"><a href="#cb11-50"></a>    ),</span>
+<span id="cb11-51"><a href="#cb11-51"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb11-52"><a href="#cb11-52"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb11-53"><a href="#cb11-53"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb11-54"><a href="#cb11-54"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb11-55"><a href="#cb11-55"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb11-56"><a href="#cb11-56"></a>      <span class="at">geom_mean =</span> <span class="st">"Geometric Mean"</span>,</span>
+<span id="cb11-57"><a href="#cb11-57"></a>      <span class="at">geom_cv =</span> <span class="st">"CV % Geometric Mean"</span>,</span>
+<span id="cb11-58"><a href="#cb11-58"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb11-59"><a href="#cb11-59"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb11-60"><a href="#cb11-60"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb11-61"><a href="#cb11-61"></a>    ),</span>
+<span id="cb11-62"><a href="#cb11-62"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb11-63"><a href="#cb11-63"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb11-64"><a href="#cb11-64"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-65"><a href="#cb11-65"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-66"><a href="#cb11-66"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-67"><a href="#cb11-67"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-68"><a href="#cb11-68"></a>      <span class="at">geom_mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-69"><a href="#cb11-69"></a>      <span class="at">geom_cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb11-70"><a href="#cb11-70"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb11-71"><a href="#cb11-71"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb11-72"><a href="#cb11-72"></a>    )</span>
+<span id="cb11-73"><a href="#cb11-73"></a>  )</span>
+<span id="cb11-74"><a href="#cb11-74"></a><span class="in">```</span></span>
+<span id="cb11-75"><a href="#cb11-75"></a></span>
+<span id="cb11-76"><a href="#cb11-76"></a><span class="fu">#### Plasma Drug X</span></span>
+<span id="cb11-77"><a href="#cb11-77"></a></span>
+<span id="cb11-78"><a href="#cb11-78"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb11-79"><a href="#cb11-79"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-80"><a href="#cb11-80"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-81"><a href="#cb11-81"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-82"><a href="#cb11-82"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-83"><a href="#cb11-83"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-84"><a href="#cb11-84"></a></span>
+<span id="cb11-85"><a href="#cb11-85"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb11-86"><a href="#cb11-86"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-87"><a href="#cb11-87"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-88"><a href="#cb11-88"></a>result</span>
+<span id="cb11-89"><a href="#cb11-89"></a><span class="in">```</span></span>
+<span id="cb11-90"><a href="#cb11-90"></a></span>
+<span id="cb11-91"><a href="#cb11-91"></a><span class="fu">#### Plasma Drug Y</span></span>
+<span id="cb11-92"><a href="#cb11-92"></a></span>
+<span id="cb11-93"><a href="#cb11-93"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb11-94"><a href="#cb11-94"></a>adpp1 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb11-95"><a href="#cb11-95"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb11-96"><a href="#cb11-96"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb11-97"><a href="#cb11-97"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb11-98"><a href="#cb11-98"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">reorder</span>(PKPARAM, TLG_ORDER))</span>
+<span id="cb11-99"><a href="#cb11-99"></a></span>
+<span id="cb11-100"><a href="#cb11-100"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp1)</span>
+<span id="cb11-101"><a href="#cb11-101"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Summary of"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPSPEC), <span class="st">"PK Parameter by Treatment Arm, PK Population"</span>)</span>
+<span id="cb11-102"><a href="#cb11-102"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp1<span class="sc">$</span>AVISIT))</span>
+<span id="cb11-103"><a href="#cb11-103"></a>result</span>
+<span id="cb11-104"><a href="#cb11-104"></a><span class="in">```</span></span>
+<span id="cb11-105"><a href="#cb11-105"></a></span>
+<span id="cb11-106"><a href="#cb11-106"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb11-107"><a href="#cb11-107"></a></span>
+<span id="cb11-108"><a href="#cb11-108"></a><span class="fu">## `teal` App</span></span>
+<span id="cb11-109"><a href="#cb11-109"></a></span>
+<span id="cb11-110"><a href="#cb11-110"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb11-111"><a href="#cb11-111"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb11-112"><a href="#cb11-112"></a></span>
+<span id="cb11-113"><a href="#cb11-113"></a><span class="co"># In progress</span></span>
+<span id="cb11-114"><a href="#cb11-114"></a><span class="in">```</span></span>
+<span id="cb11-115"><a href="#cb11-115"></a></span>
+<span id="cb11-116"><a href="#cb11-116"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb11-117"><a href="#cb11-117"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
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diff --git a/stable/tables/pharmacokinetic/pkpt08.html b/stable/tables/pharmacokinetic/pkpt08.html
new file mode 100644
index 0000000000..65a79325cd
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt08.html
@@ -0,0 +1,2146 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
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+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+span.smallcaps{font-variant: small-caps;}
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+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
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+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">PKPT08</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Summary of Cumulative Amount of Drug Eliminated and Cumulative Percentage of Drug Recovered (Stats in Columns)</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table – Plasma</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt08_cache/html/setup_2227f52a33e1d45c66fad70d50142fce">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">filter</span>(PPSTINT <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PPENINT <span class="sc">!=</span> <span class="st">"NA"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>  <span class="fu">mutate</span>(<span class="at">PPINT =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="st">"[PH]"</span>, <span class="st">""</span>, PPSTINT), <span class="st">"-"</span>, <span class="fu">gsub</span>(<span class="st">"[PH]"</span>, <span class="st">""</span>, PPENINT))))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt08_cache/html/variant1_834bb6b7470b5d9b51ca5e0feb6b6268">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># create layout</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">add_overall_col</span>(<span class="st">"Accumulation Interval (hours)"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"PPINT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"PKPARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ACTARM"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb2-14"><a href="#cb2-14"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-15"><a href="#cb2-15"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb2-16"><a href="#cb2-16"></a>      <span class="st">"median"</span>, <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>    ),</span>
+<span id="cb2-18"><a href="#cb2-18"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb2-24"><a href="#cb2-24"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb2-25"><a href="#cb2-25"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb2-26"><a href="#cb2-26"></a>    ),</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-30"><a href="#cb2-30"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-31"><a href="#cb2-31"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-33"><a href="#cb2-33"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb2-34"><a href="#cb2-34"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    )</span>
+<span id="cb2-36"><a href="#cb2-36"></a>  )</span>
+<span id="cb2-37"><a href="#cb2-37"></a></span>
+<span id="cb2-38"><a href="#cb2-38"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="fu">filter</span>(</span>
+<span id="cb2-40"><a href="#cb2-40"></a>    AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>,</span>
+<span id="cb2-41"><a href="#cb2-41"></a>    PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb2-42"><a href="#cb2-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-43"><a href="#cb2-43"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb2-45"><a href="#cb2-45"></a>    <span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))</span>
+<span id="cb2-46"><a href="#cb2-46"></a>  )</span>
+<span id="cb2-47"><a href="#cb2-47"></a></span>
+<span id="cb2-48"><a href="#cb2-48"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb2-49"><a href="#cb2-49"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb2-50"><a href="#cb2-50"></a>  <span class="st">"Summary of Cumulative Amount and Percentage of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"Recovered from</span><span class="sc">\n</span><span class="st">"</span>,</span>
+<span id="cb2-51"><a href="#cb2-51"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"following"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>REGIMEN), <span class="st">"Administration for"</span>,</span>
+<span id="cb2-52"><a href="#cb2-52"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPINT)[<span class="fu">length</span>(<span class="fu">unique</span>(adpp0<span class="sc">$</span>PPINT))], <span class="st">"hours, PK Population"</span></span>
+<span id="cb2-53"><a href="#cb2-53"></a>)</span>
+<span id="cb2-54"><a href="#cb2-54"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb2-55"><a href="#cb2-55"></a></span>
+<span id="cb2-56"><a href="#cb2-56"></a><span class="fu">cat</span>(rtables<span class="sc">::</span><span class="fu">toString</span>(result, <span class="at">indent_size =</span> <span class="dv">10</span>))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Summary of Cumulative Amount and Percentage of Urine Recovered from
+ Plasma Drug X following BID Administration for 0-24 hours, PK Population
+Analyte: Plasma Drug X 
+Visit: CYCLE 1 DAY 1
+
+—————————————————————————————————————————————————————————————————
+Treatment Arm               Accumulation Interval (hours)        
+                            0-12                    0-24         
+                     Ae (mg)     Fe (%)      Ae (mg)     Fe (%)  
+—————————————————————————————————————————————————————————————————
+ARM A                                                            
+          n            134         134         134         134   
+          Mean      1.551e+00   1.571e+01   1.551e+00   1.571e+01
+          SD        3.391e-01   3.354e+00   3.391e-01   3.354e+00
+          CV (%)      21.9        21.4        21.9        21.4   
+          Median    1.547e+00   1.577e+01   1.547e+00   1.577e+01
+          Minimum   7.021e-01   8.147e+00   7.021e-01   8.147e+00
+          Maximum   2.464e+00   2.452e+01   2.464e+00   2.452e+01
+ARM C                                                            
+          n            132         132         132         132   
+          Mean      1.535e+00   1.609e+01   1.535e+00   1.609e+01
+          SD        2.983e-01   3.109e+00   2.983e-01   3.109e+00
+          CV (%)      19.4        19.3        19.4        19.3   
+          Median    1.547e+00   1.604e+01   1.547e+00   1.604e+01
+          Minimum   8.502e-01   8.503e+00   8.502e-01   8.503e+00
+          Maximum   2.208e+00   2.443e+01   2.208e+00   2.443e+01</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt08_cache/html/teal_72e54bb8f080fe1a1ecad09815540a19">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt08_cache/html/sessioninfo_75750437dbc55d436ad1eee72a9e462d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] scda_0.1.6       dplyr_1.1.3     
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      
+[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      
+[45] pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt08_cache/html/snapshot_e9d193b533db8d58ed7c7e9b9b6085f3">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt08.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
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+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
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+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
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+      } else {
+        el.classList.add('notransition');
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+    // Switch the stylesheets
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+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
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+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
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+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
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+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
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+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
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+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
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+      return storageValue != null ? storageValue : localAlternateSentinel;
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+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
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+      <a href="../../tables/pharmacokinetic/pkpt07.html" class="pagination-link">
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+  <div class="nav-page nav-page-next">
+      <a href="../../tables/pharmacokinetic/pkpt11.html" class="pagination-link">
+        <span class="nav-page-text">PKPT11</span> <i class="bi bi-arrow-right-short"></i>
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKPT08</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Summary of Cumulative Amount of Drug Eliminated and Cumulative Percentage of Drug Recovered (Stats in Columns)</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>  <span class="fu">filter</span>(PPSTINT <span class="sc">!=</span> <span class="st">"NA"</span> <span class="sc">&amp;</span> PPENINT <span class="sc">!=</span> <span class="st">"NA"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>  <span class="fu">mutate</span>(<span class="at">PPINT =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="st">"[PH]"</span>, <span class="st">""</span>, PPSTINT), <span class="st">"-"</span>, <span class="fu">gsub</span>(<span class="st">"[PH]"</span>, <span class="st">""</span>, PPENINT))))</span>
+<span id="cb8-25"><a href="#cb8-25"></a><span class="in">```</span></span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a><span class="fu">## Standard Table -- Plasma</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a></span>
+<span id="cb8-29"><a href="#cb8-29"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-30"><a href="#cb8-30"></a><span class="co"># create layout</span></span>
+<span id="cb8-31"><a href="#cb8-31"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-32"><a href="#cb8-32"></a>  <span class="fu">add_overall_col</span>(<span class="st">"Accumulation Interval (hours)"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-33"><a href="#cb8-33"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"PPINT"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-34"><a href="#cb8-34"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"PKPARAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-36"><a href="#cb8-36"></a>    <span class="at">var =</span> <span class="st">"ARMCD"</span>,</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="at">split_fun =</span> <span class="fu">trim_levels_in_group</span>(<span class="st">"ACTARM"</span>),</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">split_label =</span> <span class="st">"Treatment Arm"</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">analyze_vars</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="at">vars =</span> <span class="st">"AVAL"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">.stats =</span> <span class="fu">c</span>(</span>
+<span id="cb8-44"><a href="#cb8-44"></a>      <span class="st">"n"</span>, <span class="st">"mean"</span>, <span class="st">"sd"</span>, <span class="st">"cv"</span>,</span>
+<span id="cb8-45"><a href="#cb8-45"></a>      <span class="st">"median"</span>, <span class="st">"min"</span>, <span class="st">"max"</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>    ),</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-48"><a href="#cb8-48"></a>      <span class="at">n =</span> <span class="st">"n"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>      <span class="at">mean =</span> <span class="st">"Mean"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>      <span class="at">sd =</span> <span class="st">"SD"</span>,</span>
+<span id="cb8-51"><a href="#cb8-51"></a>      <span class="at">cv =</span> <span class="st">"CV (%)"</span>,</span>
+<span id="cb8-52"><a href="#cb8-52"></a>      <span class="at">median =</span> <span class="st">"Median"</span>,</span>
+<span id="cb8-53"><a href="#cb8-53"></a>      <span class="at">min =</span> <span class="st">"Minimum"</span>,</span>
+<span id="cb8-54"><a href="#cb8-54"></a>      <span class="at">max =</span> <span class="st">"Maximum"</span></span>
+<span id="cb8-55"><a href="#cb8-55"></a>    ),</span>
+<span id="cb8-56"><a href="#cb8-56"></a>    <span class="at">.formats =</span> <span class="fu">c</span>(</span>
+<span id="cb8-57"><a href="#cb8-57"></a>      <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb8-58"><a href="#cb8-58"></a>      <span class="at">mean =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-59"><a href="#cb8-59"></a>      <span class="at">sd =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-60"><a href="#cb8-60"></a>      <span class="at">cv =</span> <span class="st">"xx.x"</span>,</span>
+<span id="cb8-61"><a href="#cb8-61"></a>      <span class="at">median =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-62"><a href="#cb8-62"></a>      <span class="at">min =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-63"><a href="#cb8-63"></a>      <span class="at">max =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb8-64"><a href="#cb8-64"></a>    )</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  )</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-68"><a href="#cb8-68"></a>  <span class="fu">filter</span>(</span>
+<span id="cb8-69"><a href="#cb8-69"></a>    AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>,</span>
+<span id="cb8-70"><a href="#cb8-70"></a>    PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span></span>
+<span id="cb8-71"><a href="#cb8-71"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-72"><a href="#cb8-72"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-73"><a href="#cb8-73"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-74"><a href="#cb8-74"></a>    <span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))</span>
+<span id="cb8-75"><a href="#cb8-75"></a>  )</span>
+<span id="cb8-76"><a href="#cb8-76"></a></span>
+<span id="cb8-77"><a href="#cb8-77"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb8-78"><a href="#cb8-78"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(</span>
+<span id="cb8-79"><a href="#cb8-79"></a>  <span class="st">"Summary of Cumulative Amount and Percentage of"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPSPEC), <span class="st">"Recovered from</span><span class="sc">\n</span><span class="st">"</span>,</span>
+<span id="cb8-80"><a href="#cb8-80"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"following"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>REGIMEN), <span class="st">"Administration for"</span>,</span>
+<span id="cb8-81"><a href="#cb8-81"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPINT)[<span class="fu">length</span>(<span class="fu">unique</span>(adpp0<span class="sc">$</span>PPINT))], <span class="st">"hours, PK Population"</span></span>
+<span id="cb8-82"><a href="#cb8-82"></a>)</span>
+<span id="cb8-83"><a href="#cb8-83"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT), <span class="st">"</span><span class="sc">\n</span><span class="st">Visit:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>AVISIT))</span>
+<span id="cb8-84"><a href="#cb8-84"></a></span>
+<span id="cb8-85"><a href="#cb8-85"></a><span class="fu">cat</span>(rtables<span class="sc">::</span><span class="fu">toString</span>(result, <span class="at">indent_size =</span> <span class="dv">10</span>))</span>
+<span id="cb8-86"><a href="#cb8-86"></a><span class="in">```</span></span>
+<span id="cb8-87"><a href="#cb8-87"></a></span>
+<span id="cb8-88"><a href="#cb8-88"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-89"><a href="#cb8-89"></a></span>
+<span id="cb8-90"><a href="#cb8-90"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-91"><a href="#cb8-91"></a></span>
+<span id="cb8-92"><a href="#cb8-92"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-93"><a href="#cb8-93"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-94"><a href="#cb8-94"></a></span>
+<span id="cb8-95"><a href="#cb8-95"></a><span class="co"># In progress</span></span>
+<span id="cb8-96"><a href="#cb8-96"></a><span class="in">```</span></span>
+<span id="cb8-97"><a href="#cb8-97"></a></span>
+<span id="cb8-98"><a href="#cb8-98"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-99"><a href="#cb8-99"></a></span>
+<span id="cb8-100"><a href="#cb8-100"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
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\ No newline at end of file
diff --git a/stable/tables/pharmacokinetic/pkpt11.html b/stable/tables/pharmacokinetic/pkpt11.html
new file mode 100644
index 0000000000..a8ca0d3e3c
--- /dev/null
+++ b/stable/tables/pharmacokinetic/pkpt11.html
@@ -0,0 +1,2275 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - PKPT11</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
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+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
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+cookieconsent.run({
+  "notice_banner_type":"simple",
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+  "notice_banner_reject_button_hide":false,
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+<link rel="stylesheet" href="../../assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - PKPT11">
+<meta property="og:description" content="Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX">
+<meta property="og:site-name" content="TLG Catalog">
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+  <i class="bi"></i>
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+</a>
+</div>
+            <div id="quarto-search" class="" title="Search"></div>
+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
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+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
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+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
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+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
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+ <span class="menu-text">PKPG01</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
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+ <span class="menu-text">PKPG03</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
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+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
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+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
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+<div class="quarto-title-block"><div><h1 class="title">PKPT11</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX</p>
+</div>
+
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+
+    
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+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table – Plasma</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="pkpt11_cache/html/setup_e9691712be29d0b1e07e11fe72b56b03">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a><span class="co"># Comparator Dose - A: Drug X</span></span>
+<span id="cb1-8"><a href="#cb1-8"></a>arm_var <span class="ot">&lt;-</span> <span class="st">"TRT01A"</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>comp_dose <span class="ot">&lt;-</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>other_doses <span class="ot">&lt;-</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp[[arm_var]])[<span class="fu">unique</span>(adpp[[arm_var]]) <span class="sc">!=</span> comp_dose])</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">COMP =</span> <span class="fu">paste0</span>(TRT01A, <span class="st">"/"</span>, comp_dose),</span>
+<span id="cb1-16"><a href="#cb1-16"></a>    <span class="at">COMP_AVAL =</span> <span class="fu">ifelse</span>(TRT01A <span class="sc">==</span> comp_dose, <span class="fu">paste0</span>(AVAL, comp_dose), AVAL)</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  )</span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a><span class="cf">for</span> (dose <span class="cf">in</span> other_doses) {</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  temp_df <span class="ot">&lt;-</span> adpp[adpp[[arm_var]] <span class="sc">==</span> comp_dose, ]</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  temp_df<span class="sc">$</span>COMP <span class="ot">&lt;-</span> <span class="fu">paste0</span>(dose, <span class="st">"/"</span>, comp_dose)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  adpp <span class="ot">&lt;-</span> <span class="fu">rbind</span>(adpp, temp_df)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>}</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="co"># Plasma Drug X</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">var_relabel</span>(<span class="at">COMP =</span> <span class="st">"Comparison"</span>)</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a><span class="co"># statistics function</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>s_gmr <span class="ot">&lt;-</span> <span class="cf">function</span>(df,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>                  <span class="at">compare_dose =</span> comp_dose, <span class="co"># comparator, defaults to comp_dose defined above (string)</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a>                  <span class="at">denom =</span> <span class="cn">TRUE</span>, <span class="co"># whether to use comparator as denominator, defaults to TRUE (logical)</span></span>
+<span id="cb1-36"><a href="#cb1-36"></a>                  <span class="at">arm_var =</span> arm_var) { <span class="co"># arm variable, defaults to arm_var defined above (string)</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  which_num <span class="ot">&lt;-</span> <span class="sc">!</span><span class="fu">grepl</span>(compare_dose, df[[arm_var]])</span>
+<span id="cb1-38"><a href="#cb1-38"></a></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  x_num <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(df[which_num, ][[<span class="st">"AVAL"</span>]])</span>
+<span id="cb1-40"><a href="#cb1-40"></a>  x_num <span class="ot">&lt;-</span> x_num[<span class="sc">!</span><span class="fu">is.na</span>(x_num)]</span>
+<span id="cb1-41"><a href="#cb1-41"></a>  x_num_no_negative_vals <span class="ot">&lt;-</span> x_num</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  x_num_no_negative_vals[x_num_no_negative_vals <span class="sc">&lt;=</span> <span class="dv">0</span>] <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  x_denom <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">gsub</span>(compare_dose, <span class="st">""</span>, df[<span class="sc">!</span>which_num, ][[<span class="st">"AVAL"</span>]]))</span>
+<span id="cb1-45"><a href="#cb1-45"></a>  x_denom <span class="ot">&lt;-</span> x_denom[<span class="sc">!</span><span class="fu">is.na</span>(x_denom)]</span>
+<span id="cb1-46"><a href="#cb1-46"></a>  x_denom_no_negative_vals <span class="ot">&lt;-</span> x_denom</span>
+<span id="cb1-47"><a href="#cb1-47"></a>  x_denom_no_negative_vals[x_denom_no_negative_vals <span class="sc">&lt;=</span> <span class="dv">0</span>] <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  x_num_log <span class="ot">&lt;-</span> <span class="fu">log</span>(x_num_no_negative_vals)</span>
+<span id="cb1-50"><a href="#cb1-50"></a>  x_denom_log <span class="ot">&lt;-</span> <span class="fu">log</span>(x_denom_no_negative_vals)</span>
+<span id="cb1-51"><a href="#cb1-51"></a></span>
+<span id="cb1-52"><a href="#cb1-52"></a>  <span class="cf">if</span> (denom) {</span>
+<span id="cb1-53"><a href="#cb1-53"></a>    geom_mean_ratio <span class="ot">&lt;-</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_num_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>)) <span class="sc">/</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_denom_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>))</span>
+<span id="cb1-54"><a href="#cb1-54"></a>    geom_mean_ci <span class="ot">&lt;-</span> <span class="fu">t.test</span>(x_num_log, x_denom_log, <span class="at">conf.level =</span> <span class="fl">0.90</span>)<span class="sc">$</span>conf.int</span>
+<span id="cb1-55"><a href="#cb1-55"></a>  } <span class="cf">else</span> {</span>
+<span id="cb1-56"><a href="#cb1-56"></a>    geom_mean_ratio <span class="ot">&lt;-</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_denom_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>)) <span class="sc">/</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_num_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>))</span>
+<span id="cb1-57"><a href="#cb1-57"></a>    geom_mean_ci <span class="ot">&lt;-</span> <span class="fu">t.test</span>(x_denom_log, x_num_log, <span class="at">conf.level =</span> <span class="fl">0.90</span>)<span class="sc">$</span>conf.int</span>
+<span id="cb1-58"><a href="#cb1-58"></a>  }</span>
+<span id="cb1-59"><a href="#cb1-59"></a></span>
+<span id="cb1-60"><a href="#cb1-60"></a>  <span class="fu">list</span>(</span>
+<span id="cb1-61"><a href="#cb1-61"></a>    <span class="at">n =</span> <span class="fu">nrow</span>(df),</span>
+<span id="cb1-62"><a href="#cb1-62"></a>    <span class="at">geom_mean_ratio =</span> geom_mean_ratio,</span>
+<span id="cb1-63"><a href="#cb1-63"></a>    <span class="at">gmr_ci_lwr =</span> <span class="fu">exp</span>(geom_mean_ci[<span class="dv">1</span>]),</span>
+<span id="cb1-64"><a href="#cb1-64"></a>    <span class="at">gmr_ci_upr =</span> <span class="fu">exp</span>(geom_mean_ci[<span class="dv">2</span>])</span>
+<span id="cb1-65"><a href="#cb1-65"></a>  )</span>
+<span id="cb1-66"><a href="#cb1-66"></a>}</span>
+<span id="cb1-67"><a href="#cb1-67"></a></span>
+<span id="cb1-68"><a href="#cb1-68"></a>afun_pk_gmr <span class="ot">&lt;-</span> <span class="cf">function</span>(<span class="at">.formats =</span> <span class="fu">list</span>(</span>
+<span id="cb1-69"><a href="#cb1-69"></a>                          <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb1-70"><a href="#cb1-70"></a>                          <span class="at">geom_mean_ratio =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb1-71"><a href="#cb1-71"></a>                          <span class="at">gmr_ci_lwr =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb1-72"><a href="#cb1-72"></a>                          <span class="at">gmr_ci_upr =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb1-73"><a href="#cb1-73"></a>                        ),</span>
+<span id="cb1-74"><a href="#cb1-74"></a>                        <span class="at">compare_dose =</span> comp_dose,</span>
+<span id="cb1-75"><a href="#cb1-75"></a>                        <span class="at">denom =</span> <span class="cn">TRUE</span>) {</span>
+<span id="cb1-76"><a href="#cb1-76"></a>  checkmate<span class="sc">::</span><span class="fu">assert_list</span>(.formats)</span>
+<span id="cb1-77"><a href="#cb1-77"></a>  checkmate<span class="sc">::</span><span class="fu">assert_subset</span>(<span class="fu">names</span>(.formats), <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"geom_mean_ratio"</span>, <span class="st">"gmr_ci_lwr"</span>, <span class="st">"gmr_ci_upr"</span>))</span>
+<span id="cb1-78"><a href="#cb1-78"></a></span>
+<span id="cb1-79"><a href="#cb1-79"></a>  afun_lst <span class="ot">&lt;-</span> <span class="fu">Map</span>(</span>
+<span id="cb1-80"><a href="#cb1-80"></a>    <span class="cf">function</span>(stat, fmt, compare_dose, denom, arm_var) {</span>
+<span id="cb1-81"><a href="#cb1-81"></a>      <span class="cf">function</span>(df, .spl_context) {</span>
+<span id="cb1-82"><a href="#cb1-82"></a>        x_stat <span class="ot">&lt;-</span> <span class="fu">s_gmr</span>(df, <span class="at">compare_dose =</span> compare_dose, <span class="at">denom =</span> denom, <span class="at">arm_var =</span> arm_var)[[stat]]</span>
+<span id="cb1-83"><a href="#cb1-83"></a>        <span class="fu">rcell</span>(x_stat, <span class="at">format =</span> fmt, <span class="at">label =</span> <span class="fu">tail</span>(.spl_context<span class="sc">$</span>value, <span class="dv">1</span>))</span>
+<span id="cb1-84"><a href="#cb1-84"></a>      }</span>
+<span id="cb1-85"><a href="#cb1-85"></a>    },</span>
+<span id="cb1-86"><a href="#cb1-86"></a>    <span class="at">stat =</span> <span class="fu">names</span>(.formats),</span>
+<span id="cb1-87"><a href="#cb1-87"></a>    <span class="at">fmt =</span> .formats,</span>
+<span id="cb1-88"><a href="#cb1-88"></a>    <span class="at">compare_dose =</span> compare_dose,</span>
+<span id="cb1-89"><a href="#cb1-89"></a>    <span class="at">denom =</span> denom,</span>
+<span id="cb1-90"><a href="#cb1-90"></a>    <span class="at">arm_var =</span> arm_var</span>
+<span id="cb1-91"><a href="#cb1-91"></a>  )</span>
+<span id="cb1-92"><a href="#cb1-92"></a></span>
+<span id="cb1-93"><a href="#cb1-93"></a>  afun_lst</span>
+<span id="cb1-94"><a href="#cb1-94"></a>}</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="pkpt11_cache/html/variant1_24b4090378a9fe3a326280ceab6f1a37">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># create layout</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"AUCinf obs (day*ug/mL)"</span>, <span class="st">"Cmax (ug/mL)"</span>)),</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">var =</span> <span class="st">"COMP"</span>,</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="fu">paste0</span>(comp_dose, <span class="st">"/"</span>, comp_dose)),</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">indent_mod =</span> 11L,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb2-16"><a href="#cb2-16"></a>    <span class="at">vars =</span> <span class="fu">rep</span>(<span class="st">"AVAL"</span>, <span class="dv">4</span>),</span>
+<span id="cb2-17"><a href="#cb2-17"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-18"><a href="#cb2-18"></a>      <span class="st">"n"</span>,</span>
+<span id="cb2-19"><a href="#cb2-19"></a>      <span class="st">"Geometric Mean Ratio"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>      <span class="st">"90% CI Lower Bound"</span>,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>      <span class="st">"90% CI Upper Bound"</span></span>
+<span id="cb2-22"><a href="#cb2-22"></a>    )</span>
+<span id="cb2-23"><a href="#cb2-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  <span class="fu">analyze_colvars</span>(</span>
+<span id="cb2-25"><a href="#cb2-25"></a>    <span class="at">afun =</span> <span class="fu">afun_pk_gmr</span>(),</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="at">extra_args =</span> <span class="fu">list</span>(</span>
+<span id="cb2-27"><a href="#cb2-27"></a>      <span class="at">compare_dose =</span> comp_dose,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>      <span class="at">denom =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-29"><a href="#cb2-29"></a>      <span class="at">arm_var =</span> arm_var</span>
+<span id="cb2-30"><a href="#cb2-30"></a>    )</span>
+<span id="cb2-31"><a href="#cb2-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-32"><a href="#cb2-32"></a>  <span class="fu">append_varlabels</span>(adpp0, <span class="st">"COMP"</span>, 12L)</span>
+<span id="cb2-33"><a href="#cb2-33"></a></span>
+<span id="cb2-34"><a href="#cb2-34"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb2-35"><a href="#cb2-35"></a></span>
+<span id="cb2-36"><a href="#cb2-36"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste0</span>(</span>
+<span id="cb2-37"><a href="#cb2-37"></a>  <span class="st">"Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX Following "</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>REGIMEN), <span class="st">"</span><span class="sc">\n</span><span class="st">of "</span>, comp_dose, <span class="st">" in Comparison with "</span>,</span>
+<span id="cb2-39"><a href="#cb2-39"></a>  <span class="fu">paste</span>(other_doses, <span class="at">collapse =</span> <span class="st">" &amp; "</span>), <span class="st">", PK Population"</span></span>
+<span id="cb2-40"><a href="#cb2-40"></a>)</span>
+<span id="cb2-41"><a href="#cb2-41"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT))</span>
+<span id="cb2-42"><a href="#cb2-42"></a></span>
+<span id="cb2-43"><a href="#cb2-43"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX Following BID
+of A: Drug X in Comparison with C: Combination, PK Population
+Analyte: Plasma Drug X
+
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+PK Parameter                                                                                                           
+                        Comparison                  n    Geometric Mean Ratio   90% CI Lower Bound   90% CI Upper Bound
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+AUCinf obs (day*ug/mL)                                                                                                 
+                        C: Combination/A: Drug X   266        9.615e-01             9.247e-01            9.998e-01     
+Cmax (ug/mL)                                                                                                           
+                        C: Combination/A: Drug X   266        9.974e-01             9.583e-01            1.038e+00     </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="pkpt11_cache/html/teal_179279f2ea0a912b2eeb2ad455274804">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="pkpt11_cache/html/sessioninfo_7a469d1647c1f66831a5f1fc4c12b052">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb5"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb5-1"><a href="#cb5-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] tern_0.9.0       rtables_0.6.3    magrittr_2.0.3   formatters_0.5.2
+[5] dplyr_1.1.3      scda_0.1.6      
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1   checkmate_2.2.0  
+[21] tibble_3.2.1      munsell_0.5.0     pillar_1.9.0      rlang_1.1.1      
+[25] utf8_1.2.3        testthat_3.1.10   broom_1.0.5       xfun_0.40        
+[29] cli_3.6.1         Rdpack_2.5        digest_0.6.33     grid_4.3.1       
+[33] rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3       evaluate_0.21    
+[37] glue_1.6.2        codetools_0.2-19  survival_3.5-7    fansi_1.0.4      
+[41] colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25    tools_4.3.1      
+[45] pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="pkpt11_cache/html/snapshot_e908328c142f32f2b3171f6c0d401e12">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-2"><a href="#cb7-2"></a></span>
+<span id="cb7-3"><a href="#cb7-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb7-4"><a href="#cb7-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb7-5"><a href="#cb7-5"></a></span>
+<span id="cb7-6"><a href="#cb7-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb7-7"><a href="#cb7-7"></a></span>
+<span id="cb7-8"><a href="#cb7-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb7-9"><a href="#cb7-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb7-10"><a href="#cb7-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb7-11"><a href="#cb7-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/pharmacokinetic/pkpt11.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+      <a href="../../tables/pharmacokinetic/pkpt08.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">PKPT08</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/risk-management-plan/rmpt01.html" class="pagination-link">
+        <span class="nav-page-text">RMPT01</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb8" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb8-1"><a href="#cb8-1"></a><span class="co">---</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a><span class="an">title:</span><span class="co"> PKPT11</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a><span class="an">subtitle:</span><span class="co"> Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a><span class="co">---</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a></span>
+<span id="cb8-6"><a href="#cb8-6"></a>------------------------------------------------------------------------</span>
+<span id="cb8-7"><a href="#cb8-7"></a></span>
+<span id="cb8-8"><a href="#cb8-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb8-9"><a href="#cb8-9"></a></span>
+<span id="cb8-10"><a href="#cb8-10"></a>::: panel-tabset</span>
+<span id="cb8-11"><a href="#cb8-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a></span>
+<span id="cb8-13"><a href="#cb8-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb8-14"><a href="#cb8-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-15"><a href="#cb8-15"></a></span>
+<span id="cb8-16"><a href="#cb8-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb8-17"><a href="#cb8-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb8-18"><a href="#cb8-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb8-19"><a href="#cb8-19"></a></span>
+<span id="cb8-20"><a href="#cb8-20"></a>adpp <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adpp"</span>)</span>
+<span id="cb8-21"><a href="#cb8-21"></a></span>
+<span id="cb8-22"><a href="#cb8-22"></a><span class="co"># Comparator Dose - A: Drug X</span></span>
+<span id="cb8-23"><a href="#cb8-23"></a>arm_var <span class="ot">&lt;-</span> <span class="st">"TRT01A"</span></span>
+<span id="cb8-24"><a href="#cb8-24"></a>comp_dose <span class="ot">&lt;-</span> <span class="st">"A: Drug X"</span></span>
+<span id="cb8-25"><a href="#cb8-25"></a>other_doses <span class="ot">&lt;-</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adpp[[arm_var]])[<span class="fu">unique</span>(adpp[[arm_var]]) <span class="sc">!=</span> comp_dose])</span>
+<span id="cb8-26"><a href="#cb8-26"></a></span>
+<span id="cb8-27"><a href="#cb8-27"></a>adpp <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">filter</span>(AVISIT <span class="sc">==</span> <span class="st">"CYCLE 1 DAY 1"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="at">COMP =</span> <span class="fu">paste0</span>(TRT01A, <span class="st">"/"</span>, comp_dose),</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">COMP_AVAL =</span> <span class="fu">ifelse</span>(TRT01A <span class="sc">==</span> comp_dose, <span class="fu">paste0</span>(AVAL, comp_dose), AVAL)</span>
+<span id="cb8-32"><a href="#cb8-32"></a>  )</span>
+<span id="cb8-33"><a href="#cb8-33"></a></span>
+<span id="cb8-34"><a href="#cb8-34"></a><span class="cf">for</span> (dose <span class="cf">in</span> other_doses) {</span>
+<span id="cb8-35"><a href="#cb8-35"></a>  temp_df <span class="ot">&lt;-</span> adpp[adpp[[arm_var]] <span class="sc">==</span> comp_dose, ]</span>
+<span id="cb8-36"><a href="#cb8-36"></a>  temp_df<span class="sc">$</span>COMP <span class="ot">&lt;-</span> <span class="fu">paste0</span>(dose, <span class="st">"/"</span>, comp_dose)</span>
+<span id="cb8-37"><a href="#cb8-37"></a>  adpp <span class="ot">&lt;-</span> <span class="fu">rbind</span>(adpp, temp_df)</span>
+<span id="cb8-38"><a href="#cb8-38"></a>}</span>
+<span id="cb8-39"><a href="#cb8-39"></a></span>
+<span id="cb8-40"><a href="#cb8-40"></a><span class="co"># Plasma Drug X</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>adpp0 <span class="ot">&lt;-</span> adpp <span class="sc">%&gt;%</span></span>
+<span id="cb8-42"><a href="#cb8-42"></a>  <span class="fu">filter</span>(PPCAT <span class="sc">==</span> <span class="st">"Plasma Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-43"><a href="#cb8-43"></a>  <span class="fu">h_pkparam_sort</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-44"><a href="#cb8-44"></a>  <span class="fu">mutate</span>(<span class="at">PKPARAM =</span> <span class="fu">factor</span>(<span class="fu">paste0</span>(TLG_DISPLAY, <span class="st">" ("</span>, AVALU, <span class="st">")"</span>))) <span class="sc">%&gt;%</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>  <span class="fu">var_relabel</span>(<span class="at">COMP =</span> <span class="st">"Comparison"</span>)</span>
+<span id="cb8-46"><a href="#cb8-46"></a></span>
+<span id="cb8-47"><a href="#cb8-47"></a><span class="co"># statistics function</span></span>
+<span id="cb8-48"><a href="#cb8-48"></a>s_gmr <span class="ot">&lt;-</span> <span class="cf">function</span>(df,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>                  <span class="at">compare_dose =</span> comp_dose, <span class="co"># comparator, defaults to comp_dose defined above (string)</span></span>
+<span id="cb8-50"><a href="#cb8-50"></a>                  <span class="at">denom =</span> <span class="cn">TRUE</span>, <span class="co"># whether to use comparator as denominator, defaults to TRUE (logical)</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a>                  <span class="at">arm_var =</span> arm_var) { <span class="co"># arm variable, defaults to arm_var defined above (string)</span></span>
+<span id="cb8-52"><a href="#cb8-52"></a>  which_num <span class="ot">&lt;-</span> <span class="sc">!</span><span class="fu">grepl</span>(compare_dose, df[[arm_var]])</span>
+<span id="cb8-53"><a href="#cb8-53"></a></span>
+<span id="cb8-54"><a href="#cb8-54"></a>  x_num <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(df[which_num, ][[<span class="st">"AVAL"</span>]])</span>
+<span id="cb8-55"><a href="#cb8-55"></a>  x_num <span class="ot">&lt;-</span> x_num[<span class="sc">!</span><span class="fu">is.na</span>(x_num)]</span>
+<span id="cb8-56"><a href="#cb8-56"></a>  x_num_no_negative_vals <span class="ot">&lt;-</span> x_num</span>
+<span id="cb8-57"><a href="#cb8-57"></a>  x_num_no_negative_vals[x_num_no_negative_vals <span class="sc">&lt;=</span> <span class="dv">0</span>] <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb8-58"><a href="#cb8-58"></a></span>
+<span id="cb8-59"><a href="#cb8-59"></a>  x_denom <span class="ot">&lt;-</span> <span class="fu">as.numeric</span>(<span class="fu">gsub</span>(compare_dose, <span class="st">""</span>, df[<span class="sc">!</span>which_num, ][[<span class="st">"AVAL"</span>]]))</span>
+<span id="cb8-60"><a href="#cb8-60"></a>  x_denom <span class="ot">&lt;-</span> x_denom[<span class="sc">!</span><span class="fu">is.na</span>(x_denom)]</span>
+<span id="cb8-61"><a href="#cb8-61"></a>  x_denom_no_negative_vals <span class="ot">&lt;-</span> x_denom</span>
+<span id="cb8-62"><a href="#cb8-62"></a>  x_denom_no_negative_vals[x_denom_no_negative_vals <span class="sc">&lt;=</span> <span class="dv">0</span>] <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb8-63"><a href="#cb8-63"></a></span>
+<span id="cb8-64"><a href="#cb8-64"></a>  x_num_log <span class="ot">&lt;-</span> <span class="fu">log</span>(x_num_no_negative_vals)</span>
+<span id="cb8-65"><a href="#cb8-65"></a>  x_denom_log <span class="ot">&lt;-</span> <span class="fu">log</span>(x_denom_no_negative_vals)</span>
+<span id="cb8-66"><a href="#cb8-66"></a></span>
+<span id="cb8-67"><a href="#cb8-67"></a>  <span class="cf">if</span> (denom) {</span>
+<span id="cb8-68"><a href="#cb8-68"></a>    geom_mean_ratio <span class="ot">&lt;-</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_num_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>)) <span class="sc">/</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_denom_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>))</span>
+<span id="cb8-69"><a href="#cb8-69"></a>    geom_mean_ci <span class="ot">&lt;-</span> <span class="fu">t.test</span>(x_num_log, x_denom_log, <span class="at">conf.level =</span> <span class="fl">0.90</span>)<span class="sc">$</span>conf.int</span>
+<span id="cb8-70"><a href="#cb8-70"></a>  } <span class="cf">else</span> {</span>
+<span id="cb8-71"><a href="#cb8-71"></a>    geom_mean_ratio <span class="ot">&lt;-</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_denom_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>)) <span class="sc">/</span> <span class="fu">exp</span>(<span class="fu">mean</span>(x_num_log, <span class="at">na.rm =</span> <span class="cn">FALSE</span>))</span>
+<span id="cb8-72"><a href="#cb8-72"></a>    geom_mean_ci <span class="ot">&lt;-</span> <span class="fu">t.test</span>(x_denom_log, x_num_log, <span class="at">conf.level =</span> <span class="fl">0.90</span>)<span class="sc">$</span>conf.int</span>
+<span id="cb8-73"><a href="#cb8-73"></a>  }</span>
+<span id="cb8-74"><a href="#cb8-74"></a></span>
+<span id="cb8-75"><a href="#cb8-75"></a>  <span class="fu">list</span>(</span>
+<span id="cb8-76"><a href="#cb8-76"></a>    <span class="at">n =</span> <span class="fu">nrow</span>(df),</span>
+<span id="cb8-77"><a href="#cb8-77"></a>    <span class="at">geom_mean_ratio =</span> geom_mean_ratio,</span>
+<span id="cb8-78"><a href="#cb8-78"></a>    <span class="at">gmr_ci_lwr =</span> <span class="fu">exp</span>(geom_mean_ci[<span class="dv">1</span>]),</span>
+<span id="cb8-79"><a href="#cb8-79"></a>    <span class="at">gmr_ci_upr =</span> <span class="fu">exp</span>(geom_mean_ci[<span class="dv">2</span>])</span>
+<span id="cb8-80"><a href="#cb8-80"></a>  )</span>
+<span id="cb8-81"><a href="#cb8-81"></a>}</span>
+<span id="cb8-82"><a href="#cb8-82"></a></span>
+<span id="cb8-83"><a href="#cb8-83"></a>afun_pk_gmr <span class="ot">&lt;-</span> <span class="cf">function</span>(<span class="at">.formats =</span> <span class="fu">list</span>(</span>
+<span id="cb8-84"><a href="#cb8-84"></a>                          <span class="at">n =</span> <span class="st">"xx."</span>,</span>
+<span id="cb8-85"><a href="#cb8-85"></a>                          <span class="at">geom_mean_ratio =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-86"><a href="#cb8-86"></a>                          <span class="at">gmr_ci_lwr =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>),</span>
+<span id="cb8-87"><a href="#cb8-87"></a>                          <span class="at">gmr_ci_upr =</span> <span class="fu">sprintf_format</span>(<span class="st">"%.3e"</span>)</span>
+<span id="cb8-88"><a href="#cb8-88"></a>                        ),</span>
+<span id="cb8-89"><a href="#cb8-89"></a>                        <span class="at">compare_dose =</span> comp_dose,</span>
+<span id="cb8-90"><a href="#cb8-90"></a>                        <span class="at">denom =</span> <span class="cn">TRUE</span>) {</span>
+<span id="cb8-91"><a href="#cb8-91"></a>  checkmate<span class="sc">::</span><span class="fu">assert_list</span>(.formats)</span>
+<span id="cb8-92"><a href="#cb8-92"></a>  checkmate<span class="sc">::</span><span class="fu">assert_subset</span>(<span class="fu">names</span>(.formats), <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"geom_mean_ratio"</span>, <span class="st">"gmr_ci_lwr"</span>, <span class="st">"gmr_ci_upr"</span>))</span>
+<span id="cb8-93"><a href="#cb8-93"></a></span>
+<span id="cb8-94"><a href="#cb8-94"></a>  afun_lst <span class="ot">&lt;-</span> <span class="fu">Map</span>(</span>
+<span id="cb8-95"><a href="#cb8-95"></a>    <span class="cf">function</span>(stat, fmt, compare_dose, denom, arm_var) {</span>
+<span id="cb8-96"><a href="#cb8-96"></a>      <span class="cf">function</span>(df, .spl_context) {</span>
+<span id="cb8-97"><a href="#cb8-97"></a>        x_stat <span class="ot">&lt;-</span> <span class="fu">s_gmr</span>(df, <span class="at">compare_dose =</span> compare_dose, <span class="at">denom =</span> denom, <span class="at">arm_var =</span> arm_var)[[stat]]</span>
+<span id="cb8-98"><a href="#cb8-98"></a>        <span class="fu">rcell</span>(x_stat, <span class="at">format =</span> fmt, <span class="at">label =</span> <span class="fu">tail</span>(.spl_context<span class="sc">$</span>value, <span class="dv">1</span>))</span>
+<span id="cb8-99"><a href="#cb8-99"></a>      }</span>
+<span id="cb8-100"><a href="#cb8-100"></a>    },</span>
+<span id="cb8-101"><a href="#cb8-101"></a>    <span class="at">stat =</span> <span class="fu">names</span>(.formats),</span>
+<span id="cb8-102"><a href="#cb8-102"></a>    <span class="at">fmt =</span> .formats,</span>
+<span id="cb8-103"><a href="#cb8-103"></a>    <span class="at">compare_dose =</span> compare_dose,</span>
+<span id="cb8-104"><a href="#cb8-104"></a>    <span class="at">denom =</span> denom,</span>
+<span id="cb8-105"><a href="#cb8-105"></a>    <span class="at">arm_var =</span> arm_var</span>
+<span id="cb8-106"><a href="#cb8-106"></a>  )</span>
+<span id="cb8-107"><a href="#cb8-107"></a></span>
+<span id="cb8-108"><a href="#cb8-108"></a>  afun_lst</span>
+<span id="cb8-109"><a href="#cb8-109"></a>}</span>
+<span id="cb8-110"><a href="#cb8-110"></a><span class="in">```</span></span>
+<span id="cb8-111"><a href="#cb8-111"></a></span>
+<span id="cb8-112"><a href="#cb8-112"></a><span class="fu">## Standard Table -- Plasma</span></span>
+<span id="cb8-113"><a href="#cb8-113"></a></span>
+<span id="cb8-114"><a href="#cb8-114"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb8-115"><a href="#cb8-115"></a><span class="co"># create layout</span></span>
+<span id="cb8-116"><a href="#cb8-116"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-117"><a href="#cb8-117"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-118"><a href="#cb8-118"></a>    <span class="at">var =</span> <span class="st">"PKPARAM"</span>,</span>
+<span id="cb8-119"><a href="#cb8-119"></a>    <span class="at">label_pos =</span> <span class="st">"topleft"</span>,</span>
+<span id="cb8-120"><a href="#cb8-120"></a>    <span class="at">split_fun =</span> <span class="fu">keep_split_levels</span>(<span class="fu">c</span>(<span class="st">"AUCinf obs (day*ug/mL)"</span>, <span class="st">"Cmax (ug/mL)"</span>)),</span>
+<span id="cb8-121"><a href="#cb8-121"></a>    <span class="at">split_label =</span> <span class="st">"PK Parameter"</span></span>
+<span id="cb8-122"><a href="#cb8-122"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-123"><a href="#cb8-123"></a>  <span class="fu">split_rows_by</span>(</span>
+<span id="cb8-124"><a href="#cb8-124"></a>    <span class="at">var =</span> <span class="st">"COMP"</span>,</span>
+<span id="cb8-125"><a href="#cb8-125"></a>    <span class="at">split_fun =</span> <span class="fu">remove_split_levels</span>(<span class="fu">paste0</span>(comp_dose, <span class="st">"/"</span>, comp_dose)),</span>
+<span id="cb8-126"><a href="#cb8-126"></a>    <span class="at">indent_mod =</span> 11L,</span>
+<span id="cb8-127"><a href="#cb8-127"></a>    <span class="at">child_labels =</span> <span class="st">"hidden"</span></span>
+<span id="cb8-128"><a href="#cb8-128"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-129"><a href="#cb8-129"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb8-130"><a href="#cb8-130"></a>    <span class="at">vars =</span> <span class="fu">rep</span>(<span class="st">"AVAL"</span>, <span class="dv">4</span>),</span>
+<span id="cb8-131"><a href="#cb8-131"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-132"><a href="#cb8-132"></a>      <span class="st">"n"</span>,</span>
+<span id="cb8-133"><a href="#cb8-133"></a>      <span class="st">"Geometric Mean Ratio"</span>,</span>
+<span id="cb8-134"><a href="#cb8-134"></a>      <span class="st">"90% CI Lower Bound"</span>,</span>
+<span id="cb8-135"><a href="#cb8-135"></a>      <span class="st">"90% CI Upper Bound"</span></span>
+<span id="cb8-136"><a href="#cb8-136"></a>    )</span>
+<span id="cb8-137"><a href="#cb8-137"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-138"><a href="#cb8-138"></a>  <span class="fu">analyze_colvars</span>(</span>
+<span id="cb8-139"><a href="#cb8-139"></a>    <span class="at">afun =</span> <span class="fu">afun_pk_gmr</span>(),</span>
+<span id="cb8-140"><a href="#cb8-140"></a>    <span class="at">extra_args =</span> <span class="fu">list</span>(</span>
+<span id="cb8-141"><a href="#cb8-141"></a>      <span class="at">compare_dose =</span> comp_dose,</span>
+<span id="cb8-142"><a href="#cb8-142"></a>      <span class="at">denom =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb8-143"><a href="#cb8-143"></a>      <span class="at">arm_var =</span> arm_var</span>
+<span id="cb8-144"><a href="#cb8-144"></a>    )</span>
+<span id="cb8-145"><a href="#cb8-145"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-146"><a href="#cb8-146"></a>  <span class="fu">append_varlabels</span>(adpp0, <span class="st">"COMP"</span>, 12L)</span>
+<span id="cb8-147"><a href="#cb8-147"></a></span>
+<span id="cb8-148"><a href="#cb8-148"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> adpp0)</span>
+<span id="cb8-149"><a href="#cb8-149"></a></span>
+<span id="cb8-150"><a href="#cb8-150"></a><span class="fu">main_title</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste0</span>(</span>
+<span id="cb8-151"><a href="#cb8-151"></a>  <span class="st">"Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX Following "</span>,</span>
+<span id="cb8-152"><a href="#cb8-152"></a>  <span class="fu">unique</span>(adpp0<span class="sc">$</span>REGIMEN), <span class="st">"</span><span class="sc">\n</span><span class="st">of "</span>, comp_dose, <span class="st">" in Comparison with "</span>,</span>
+<span id="cb8-153"><a href="#cb8-153"></a>  <span class="fu">paste</span>(other_doses, <span class="at">collapse =</span> <span class="st">" &amp; "</span>), <span class="st">", PK Population"</span></span>
+<span id="cb8-154"><a href="#cb8-154"></a>)</span>
+<span id="cb8-155"><a href="#cb8-155"></a><span class="fu">subtitles</span>(result) <span class="ot">&lt;-</span> <span class="fu">paste</span>(<span class="st">"Analyte:"</span>, <span class="fu">unique</span>(adpp0<span class="sc">$</span>PPCAT))</span>
+<span id="cb8-156"><a href="#cb8-156"></a></span>
+<span id="cb8-157"><a href="#cb8-157"></a>result</span>
+<span id="cb8-158"><a href="#cb8-158"></a><span class="in">```</span></span>
+<span id="cb8-159"><a href="#cb8-159"></a></span>
+<span id="cb8-160"><a href="#cb8-160"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb8-161"><a href="#cb8-161"></a></span>
+<span id="cb8-162"><a href="#cb8-162"></a><span class="fu">## `teal` App</span></span>
+<span id="cb8-163"><a href="#cb8-163"></a></span>
+<span id="cb8-164"><a href="#cb8-164"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb8-165"><a href="#cb8-165"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb8-166"><a href="#cb8-166"></a></span>
+<span id="cb8-167"><a href="#cb8-167"></a><span class="co"># In progress</span></span>
+<span id="cb8-168"><a href="#cb8-168"></a><span class="in">```</span></span>
+<span id="cb8-169"><a href="#cb8-169"></a></span>
+<span id="cb8-170"><a href="#cb8-170"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb8-171"><a href="#cb8-171"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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\ No newline at end of file
diff --git a/stable/tables/risk-management-plan/rmpt01.html b/stable/tables/risk-management-plan/rmpt01.html
new file mode 100644
index 0000000000..fedb7bacd7
--- /dev/null
+++ b/stable/tables/risk-management-plan/rmpt01.html
@@ -0,0 +1,2329 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
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+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
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+<link href="../../site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="../../site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
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+<link href="../../site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="../../site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
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+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
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+cookieconsent.run({
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+  "notice_banner_reject_button_hide":false,
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+<link rel="stylesheet" href="../../assets/css/style.scss">
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+      <div class="navbar-brand-container">
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+ <span class="dropdown-text">Stable</span></a>
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+  <i class="bi"></i>
+  </div>
+</a>
+</div>
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+      </div> <!-- /container-fluid -->
+    </nav><nav class="quarto-secondary-nav"><div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+<!-- sidebar -->
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+      <img src="../../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
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+          </a> 
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RMPT01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Duration of Exposure for Risk Management Plan</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="rmpt01_cache/html/setup_20c9ab83e7201d2affb9ae015ce1546a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">aval_months =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">aval_months_cat =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      aval_months <span class="sc">&lt;</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"&lt; 1 month"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">1</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"1 to &lt;3 months"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">3</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">6</span> <span class="sc">~</span> <span class="st">"3 to &lt;6 months"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=6 months"</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 1 month"</span>, <span class="st">"1 to &lt;3 months"</span>, <span class="st">"3 to &lt;6 months"</span>, <span class="st">"&gt;=6 months"</span>))</span>
+<span id="cb1-38"><a href="#cb1-38"></a>  )</span>
+<span id="cb1-39"><a href="#cb1-39"></a></span>
+<span id="cb1-40"><a href="#cb1-40"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rmpt01_cache/html/variant1_6517f764e9c8914351d35e8b5d8fad2f">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">title =</span> <span class="st">"Duration of Exposure: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">var =</span> <span class="st">"aval_months_cat"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Duration of exposure"</span>))</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Duration of Exposure: Safety-Evaluable Patients
+
+——————————————————————————————————————————————————————————————————————————————
+                                            Number of Patients   Patient Time*
+Duration of exposure                             (N=400)            (N=400)   
+——————————————————————————————————————————————————————————————————————————————
+Total Number of Patients and Patient Time      217 (54.2%)           20641    
+  &lt; 1 month                                     28 (7.0%)             504     
+  1 to &lt;3 months                                79 (19.8%)           4727     
+  3 to &lt;6 months                               101 (25.2%)           13690    
+  &gt;=6 months                                     9 (2.2%)            1720     
+——————————————————————————————————————————————————————————————————————————————
+
+* Patient Time is the sum of exposure across all patients in days.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="rmpt01_cache/html/teal_25cd4f507febd7226553a065b768ba8a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb4-9"><a href="#cb4-9"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb4-19"><a href="#cb4-19"></a></span>
+<span id="cb4-20"><a href="#cb4-20"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">aval_months =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">aval_months_cat =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>      aval_months <span class="sc">&lt;</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"&lt; 1 month"</span>,</span>
+<span id="cb4-25"><a href="#cb4-25"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">1</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"1 to &lt;3 months"</span>,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">3</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">6</span> <span class="sc">~</span> <span class="st">"3 to &lt;6 months"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=6 months"</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 1 month"</span>, <span class="st">"1 to &lt;3 months"</span>, <span class="st">"3 to &lt;6 months"</span>, <span class="st">"&gt;=6 months"</span>))</span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">select</span>(<span class="sc">-</span>aval_months)</span>
+<span id="cb4-31"><a href="#cb4-31"></a></span>
+<span id="cb4-32"><a href="#cb4-32"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(labels, <span class="st">"Overall duration"</span>)</span>
+<span id="cb4-33"><a href="#cb4-33"></a></span>
+<span id="cb4-34"><a href="#cb4-34"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-36"><a href="#cb4-36"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb4-37"><a href="#cb4-37"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb4-38"><a href="#cb4-38"></a><span class="st">    labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a><span class="st">    set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb4-40"><a href="#cb4-40"></a><span class="st">    ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb4-41"><a href="#cb4-41"></a><span class="st">      distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb4-42"><a href="#cb4-42"></a><span class="st">      mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb4-43"><a href="#cb4-43"></a><span class="st">             PARAM = "Overall duration (days)",</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a><span class="st">             AVAL = sample(</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a><span class="st">             x = seq(1, 200), size = n(), replace = TRUE</span></span>
+<span id="cb4-46"><a href="#cb4-46"></a><span class="st">             ),</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a><span class="st">             AVALU = "Days") %&gt;%</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a><span class="st">      bind_rows(ADEX)</span></span>
+<span id="cb4-49"><a href="#cb4-49"></a></span>
+<span id="cb4-50"><a href="#cb4-50"></a><span class="st">    ADEX &lt;-ADEX %&gt;%</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a><span class="st">      mutate(</span></span>
+<span id="cb4-52"><a href="#cb4-52"></a><span class="st">        aval_months = day2month(AVAL),</span></span>
+<span id="cb4-53"><a href="#cb4-53"></a><span class="st">        aval_months_cat = factor(case_when(</span></span>
+<span id="cb4-54"><a href="#cb4-54"></a><span class="st">          aval_months &lt; 1 ~ "&lt; 1 month",</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a><span class="st">          aval_months &gt;= 1 &amp; aval_months &lt; 3 ~ "1 to &lt;3 months",</span></span>
+<span id="cb4-56"><a href="#cb4-56"></a><span class="st">          aval_months &gt;= 3 &amp; aval_months &lt; 6 ~ "3 to &lt;6 months",</span></span>
+<span id="cb4-57"><a href="#cb4-57"></a><span class="st">          TRUE ~ "&gt;=6 months"</span></span>
+<span id="cb4-58"><a href="#cb4-58"></a><span class="st">        ), levels = c("&lt; 1 month", "1 to &lt;3 months", "3 to &lt;6 months", "&gt;=6 months"))) %&gt;%</span></span>
+<span id="cb4-59"><a href="#cb4-59"></a><span class="st">      select(-aval_months)</span></span>
+<span id="cb4-60"><a href="#cb4-60"></a></span>
+<span id="cb4-61"><a href="#cb4-61"></a><span class="st">    var_labels(ADEX) &lt;- c(labels, "Overall duration")'</span>),</span>
+<span id="cb4-62"><a href="#cb4-62"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-63"><a href="#cb4-63"></a>  ),</span>
+<span id="cb4-64"><a href="#cb4-64"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-65"><a href="#cb4-65"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb4-66"><a href="#cb4-66"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb4-67"><a href="#cb4-67"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb4-68"><a href="#cb4-68"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-69"><a href="#cb4-69"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-70"><a href="#cb4-70"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb4-71"><a href="#cb4-71"></a>      ),</span>
+<span id="cb4-72"><a href="#cb4-72"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-73"><a href="#cb4-73"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb4-74"><a href="#cb4-74"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb4-75"><a href="#cb4-75"></a>      ),</span>
+<span id="cb4-76"><a href="#cb4-76"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-77"><a href="#cb4-77"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"aval_months_cat"</span>, <span class="st">"RACE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb4-78"><a href="#cb4-78"></a>        <span class="at">selected =</span> <span class="st">"aval_months_cat"</span></span>
+<span id="cb4-79"><a href="#cb4-79"></a>      ),</span>
+<span id="cb4-80"><a href="#cb4-80"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-81"><a href="#cb4-81"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb4-82"><a href="#cb4-82"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb4-83"><a href="#cb4-83"></a>      ),</span>
+<span id="cb4-84"><a href="#cb4-84"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-85"><a href="#cb4-85"></a>    )</span>
+<span id="cb4-86"><a href="#cb4-86"></a>  ),</span>
+<span id="cb4-87"><a href="#cb4-87"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb4-88"><a href="#cb4-88"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-89"><a href="#cb4-89"></a>  )</span>
+<span id="cb4-90"><a href="#cb4-90"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:36:31.2958 pid:13878 token:[] teal.modules.clinical Initializing tm_t_exposure</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="rmpt01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rmpt01_cache/html/sessioninfo_e1ebf08e9265d8ae7be8b2f65465fff6">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rmpt01_cache/html/snapshot_e925cbf1cf379a69a5204f9560a5d920">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/risk-management-plan/rmpt01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
+      }
+    } else {
+      disableStylesheet(alternateStylesheets);
+      toggleBodyColorPrimary();
+    }
+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
+    for (let i=0; i < toggles.length; i++) {
+      const toggle = toggles[i];
+      if (toggle) {
+        if (alternate) {
+          toggle.classList.add("alternate");     
+        } else {
+          toggle.classList.remove("alternate");
+        }
+      }
+    }
+    // Hack to workaround the fact that safari doesn't
+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> RMPT01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Duration of Exposure for Risk Management Plan</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-46"><a href="#cb10-46"></a>    <span class="at">aval_months =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb10-47"><a href="#cb10-47"></a>    <span class="at">aval_months_cat =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb10-48"><a href="#cb10-48"></a>      aval_months <span class="sc">&lt;</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"&lt; 1 month"</span>,</span>
+<span id="cb10-49"><a href="#cb10-49"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">1</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"1 to &lt;3 months"</span>,</span>
+<span id="cb10-50"><a href="#cb10-50"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">3</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">6</span> <span class="sc">~</span> <span class="st">"3 to &lt;6 months"</span>,</span>
+<span id="cb10-51"><a href="#cb10-51"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=6 months"</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 1 month"</span>, <span class="st">"1 to &lt;3 months"</span>, <span class="st">"3 to &lt;6 months"</span>, <span class="st">"&gt;=6 months"</span>))</span>
+<span id="cb10-53"><a href="#cb10-53"></a>  )</span>
+<span id="cb10-54"><a href="#cb10-54"></a></span>
+<span id="cb10-55"><a href="#cb10-55"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-56"><a href="#cb10-56"></a><span class="in">```</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a></span>
+<span id="cb10-58"><a href="#cb10-58"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a></span>
+<span id="cb10-60"><a href="#cb10-60"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-61"><a href="#cb10-61"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb10-62"><a href="#cb10-62"></a>  <span class="at">title =</span> <span class="st">"Duration of Exposure: Safety-Evaluable Patients"</span>,</span>
+<span id="cb10-63"><a href="#cb10-63"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span>,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-65"><a href="#cb10-65"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb10-67"><a href="#cb10-67"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-68"><a href="#cb10-68"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb10-69"><a href="#cb10-69"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb10-70"><a href="#cb10-70"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb10-72"><a href="#cb10-72"></a>    <span class="at">var =</span> <span class="st">"aval_months_cat"</span>,</span>
+<span id="cb10-73"><a href="#cb10-73"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Duration of exposure"</span>))</span>
+<span id="cb10-76"><a href="#cb10-76"></a></span>
+<span id="cb10-77"><a href="#cb10-77"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb10-78"><a href="#cb10-78"></a>result</span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="in">```</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a></span>
+<span id="cb10-81"><a href="#cb10-81"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a></span>
+<span id="cb10-85"><a href="#cb10-85"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a></span>
+<span id="cb10-88"><a href="#cb10-88"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-89"><a href="#cb10-89"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-90"><a href="#cb10-90"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-91"><a href="#cb10-91"></a></span>
+<span id="cb10-92"><a href="#cb10-92"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-93"><a href="#cb10-93"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-94"><a href="#cb10-94"></a></span>
+<span id="cb10-95"><a href="#cb10-95"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb10-96"><a href="#cb10-96"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb10-97"><a href="#cb10-97"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-100"><a href="#cb10-100"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-101"><a href="#cb10-101"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-102"><a href="#cb10-102"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb10-103"><a href="#cb10-103"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-106"><a href="#cb10-106"></a></span>
+<span id="cb10-107"><a href="#cb10-107"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-109"><a href="#cb10-109"></a>    <span class="at">aval_months =</span> <span class="fu">day2month</span>(AVAL),</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="at">aval_months_cat =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      aval_months <span class="sc">&lt;</span> <span class="dv">1</span> <span class="sc">~</span> <span class="st">"&lt; 1 month"</span>,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">1</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">3</span> <span class="sc">~</span> <span class="st">"1 to &lt;3 months"</span>,</span>
+<span id="cb10-113"><a href="#cb10-113"></a>      aval_months <span class="sc">&gt;=</span> <span class="dv">3</span> <span class="sc">&amp;</span> aval_months <span class="sc">&lt;</span> <span class="dv">6</span> <span class="sc">~</span> <span class="st">"3 to &lt;6 months"</span>,</span>
+<span id="cb10-114"><a href="#cb10-114"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=6 months"</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 1 month"</span>, <span class="st">"1 to &lt;3 months"</span>, <span class="st">"3 to &lt;6 months"</span>, <span class="st">"&gt;=6 months"</span>))</span>
+<span id="cb10-116"><a href="#cb10-116"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-117"><a href="#cb10-117"></a>  <span class="fu">select</span>(<span class="sc">-</span>aval_months)</span>
+<span id="cb10-118"><a href="#cb10-118"></a></span>
+<span id="cb10-119"><a href="#cb10-119"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(labels, <span class="st">"Overall duration"</span>)</span>
+<span id="cb10-120"><a href="#cb10-120"></a></span>
+<span id="cb10-121"><a href="#cb10-121"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-122"><a href="#cb10-122"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-123"><a href="#cb10-123"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-124"><a href="#cb10-124"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb10-125"><a href="#cb10-125"></a><span class="st">    labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb10-126"><a href="#cb10-126"></a><span class="st">    set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a><span class="st">    ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb10-128"><a href="#cb10-128"></a><span class="st">      distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a><span class="st">      mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb10-130"><a href="#cb10-130"></a><span class="st">             PARAM = "Overall duration (days)",</span></span>
+<span id="cb10-131"><a href="#cb10-131"></a><span class="st">             AVAL = sample(</span></span>
+<span id="cb10-132"><a href="#cb10-132"></a><span class="st">             x = seq(1, 200), size = n(), replace = TRUE</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a><span class="st">             ),</span></span>
+<span id="cb10-134"><a href="#cb10-134"></a><span class="st">             AVALU = "Days") %&gt;%</span></span>
+<span id="cb10-135"><a href="#cb10-135"></a><span class="st">      bind_rows(ADEX)</span></span>
+<span id="cb10-136"><a href="#cb10-136"></a></span>
+<span id="cb10-137"><a href="#cb10-137"></a><span class="st">    ADEX &lt;-ADEX %&gt;%</span></span>
+<span id="cb10-138"><a href="#cb10-138"></a><span class="st">      mutate(</span></span>
+<span id="cb10-139"><a href="#cb10-139"></a><span class="st">        aval_months = day2month(AVAL),</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a><span class="st">        aval_months_cat = factor(case_when(</span></span>
+<span id="cb10-141"><a href="#cb10-141"></a><span class="st">          aval_months &lt; 1 ~ "&lt; 1 month",</span></span>
+<span id="cb10-142"><a href="#cb10-142"></a><span class="st">          aval_months &gt;= 1 &amp; aval_months &lt; 3 ~ "1 to &lt;3 months",</span></span>
+<span id="cb10-143"><a href="#cb10-143"></a><span class="st">          aval_months &gt;= 3 &amp; aval_months &lt; 6 ~ "3 to &lt;6 months",</span></span>
+<span id="cb10-144"><a href="#cb10-144"></a><span class="st">          TRUE ~ "&gt;=6 months"</span></span>
+<span id="cb10-145"><a href="#cb10-145"></a><span class="st">        ), levels = c("&lt; 1 month", "1 to &lt;3 months", "3 to &lt;6 months", "&gt;=6 months"))) %&gt;%</span></span>
+<span id="cb10-146"><a href="#cb10-146"></a><span class="st">      select(-aval_months)</span></span>
+<span id="cb10-147"><a href="#cb10-147"></a></span>
+<span id="cb10-148"><a href="#cb10-148"></a><span class="st">    var_labels(ADEX) &lt;- c(labels, "Overall duration")'</span>),</span>
+<span id="cb10-149"><a href="#cb10-149"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-150"><a href="#cb10-150"></a>  ),</span>
+<span id="cb10-151"><a href="#cb10-151"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-152"><a href="#cb10-152"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb10-153"><a href="#cb10-153"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb10-154"><a href="#cb10-154"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb10-155"><a href="#cb10-155"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-156"><a href="#cb10-156"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-157"><a href="#cb10-157"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb10-158"><a href="#cb10-158"></a>      ),</span>
+<span id="cb10-159"><a href="#cb10-159"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-160"><a href="#cb10-160"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb10-161"><a href="#cb10-161"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb10-162"><a href="#cb10-162"></a>      ),</span>
+<span id="cb10-163"><a href="#cb10-163"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-164"><a href="#cb10-164"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"aval_months_cat"</span>, <span class="st">"RACE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb10-165"><a href="#cb10-165"></a>        <span class="at">selected =</span> <span class="st">"aval_months_cat"</span></span>
+<span id="cb10-166"><a href="#cb10-166"></a>      ),</span>
+<span id="cb10-167"><a href="#cb10-167"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-168"><a href="#cb10-168"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb10-169"><a href="#cb10-169"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb10-170"><a href="#cb10-170"></a>      ),</span>
+<span id="cb10-171"><a href="#cb10-171"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-172"><a href="#cb10-172"></a>    )</span>
+<span id="cb10-173"><a href="#cb10-173"></a>  ),</span>
+<span id="cb10-174"><a href="#cb10-174"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb10-175"><a href="#cb10-175"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-176"><a href="#cb10-176"></a>  )</span>
+<span id="cb10-177"><a href="#cb10-177"></a>)</span>
+<span id="cb10-178"><a href="#cb10-178"></a></span>
+<span id="cb10-179"><a href="#cb10-179"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-180"><a href="#cb10-180"></a><span class="in">```</span></span>
+<span id="cb10-181"><a href="#cb10-181"></a></span>
+<span id="cb10-182"><a href="#cb10-182"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-183"><a href="#cb10-183"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
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+
+
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+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RMPT03</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Extent of Exposure by Age Group and Gender for Risk Management Plan</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Excluding Empty Age Groups</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="rmpt03_cache/html/setup_db5309a9c6aa601ea7db007c8a65bcdc">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-31"><a href="#cb1-31"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(AGE <span class="sc">&lt;</span> <span class="dv">65</span>, <span class="st">"&lt;65"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb1-32"><a href="#cb1-32"></a>    <span class="at">AGEGR2 =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-33"><a href="#cb1-33"></a>      AGE <span class="sc">&lt;</span> <span class="dv">18</span> <span class="sc">~</span> <span class="st">"&lt; 18"</span>,</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">18</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">40</span> <span class="sc">~</span> <span class="st">"18 - 40"</span>,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      AGE <span class="sc">&gt;</span> <span class="dv">40</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"41 - 64"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 18"</span>, <span class="st">"18 - 40"</span>, <span class="st">"41 - 64"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb1-38"><a href="#cb1-38"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>    ))</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  )</span>
+<span id="cb1-43"><a href="#cb1-43"></a></span>
+<span id="cb1-44"><a href="#cb1-44"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">mutate</span>(<span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb1-47"><a href="#cb1-47"></a>    SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb1-48"><a href="#cb1-48"></a>    SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>  )))</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rmpt03_cache/html/variant1_d841538b61e0f5fe9f6299cace40640c">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Age Group and Gender: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"Total"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">var =</span> <span class="st">"AGEGR1"</span>,</span>
+<span id="cb2-13"><a href="#cb2-13"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Age group (years)"</span>))</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb2-18"><a href="#cb2-18"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Extent of Exposure by Age Group and Gender: Safety-Evaluable Patients
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                          Female                                Male                                Total               
+Age group (years)                           Number of Patients   Patient Time*   Number of Patients   Patient Time*   Number of Patients   Patient Time*
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total Number of Patients and Patient Time      134 (58.0%)           12591           83 (49.1%)           8050           217 (54.2%)           20641    
+  &lt;65                                          134 (58.0%)           12591           82 (48.5%)           7970           216 (54.0%)           20561    
+  &gt;=65                                           0 (0.0%)              0              1 (0.6%)             80              1 (0.2%)             80      
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+* Patient Time is the sum of exposure across all patients in days.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="rmpt03_cache/html/variant2_6fadce0614e004aa7767d5939ac71b1a">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="at">title =</span> <span class="st">"Duration of Exposure: Safety-Evaluable Patients"</span>,</span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"Total"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb4-9"><a href="#cb4-9"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">var =</span> <span class="st">"AGEGR2"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-15"><a href="#cb4-15"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Age group (years)"</span>))</span>
+<span id="cb4-16"><a href="#cb4-16"></a></span>
+<span id="cb4-17"><a href="#cb4-17"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb4-19"><a href="#cb4-19"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Duration of Exposure: Safety-Evaluable Patients
+
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+                                                          Female                                Male                                Total               
+Age group (years)                           Number of Patients   Patient Time*   Number of Patients   Patient Time*   Number of Patients   Patient Time*
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Total Number of Patients and Patient Time      134 (58.0%)           12591           83 (49.1%)           8050           217 (54.2%)           20641    
+  18 - 40                                      118 (51.1%)           11203           60 (35.5%)           5787           178 (44.5%)           16990    
+  41 - 64                                       16 (6.9%)            1388            22 (13.0%)           2183            38 (9.5%)            3571     
+  &gt;=65                                           0 (0.0%)              0              1 (0.6%)             80              1 (0.2%)             80      
+————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+
+* Patient Time is the sum of exposure across all patients in days.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="rmpt03_cache/html/teal_bf3bd7d7d40db16b9c9aa7f17e5f1f4e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb6-7"><a href="#cb6-7"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb6-8"><a href="#cb6-8"></a></span>
+<span id="cb6-9"><a href="#cb6-9"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb6-10"><a href="#cb6-10"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb6-15"><a href="#cb6-15"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb6-19"><a href="#cb6-19"></a></span>
+<span id="cb6-20"><a href="#cb6-20"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb6-21"><a href="#cb6-21"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb6-22"><a href="#cb6-22"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(AGE <span class="sc">&lt;</span> <span class="dv">65</span>, <span class="st">"&lt;65"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb6-23"><a href="#cb6-23"></a>    <span class="at">AGEGR2 =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb6-24"><a href="#cb6-24"></a>      AGE <span class="sc">&lt;</span> <span class="dv">18</span> <span class="sc">~</span> <span class="st">"&lt; 18"</span>,</span>
+<span id="cb6-25"><a href="#cb6-25"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">18</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">40</span> <span class="sc">~</span> <span class="st">"18 - 40"</span>,</span>
+<span id="cb6-26"><a href="#cb6-26"></a>      AGE <span class="sc">&gt;</span> <span class="dv">40</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"41 - 64"</span>,</span>
+<span id="cb6-27"><a href="#cb6-27"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb6-28"><a href="#cb6-28"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 18"</span>, <span class="st">"18 - 40"</span>, <span class="st">"41 - 64"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb6-30"><a href="#cb6-30"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>    ))</span>
+<span id="cb6-33"><a href="#cb6-33"></a>  )</span>
+<span id="cb6-34"><a href="#cb6-34"></a></span>
+<span id="cb6-35"><a href="#cb6-35"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(labels, <span class="st">"Age group (years)"</span>, <span class="st">"Age group (years)"</span>)</span>
+<span id="cb6-36"><a href="#cb6-36"></a></span>
+<span id="cb6-37"><a href="#cb6-37"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="fu">mutate</span>(<span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb6-39"><a href="#cb6-39"></a>    SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb6-41"><a href="#cb6-41"></a>  )))</span>
+<span id="cb6-42"><a href="#cb6-42"></a></span>
+<span id="cb6-43"><a href="#cb6-43"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-44"><a href="#cb6-44"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb6-46"><a href="#cb6-46"></a><span class="st">  ADSL &lt;- ADSL %&gt;% filter(ADSL$SAFFL == "Y") %&gt;%</span></span>
+<span id="cb6-47"><a href="#cb6-47"></a><span class="st">  mutate(SEX = factor(case_when(</span></span>
+<span id="cb6-48"><a href="#cb6-48"></a><span class="st">    SEX == "F" ~ "Female",</span></span>
+<span id="cb6-49"><a href="#cb6-49"></a><span class="st">    SEX == "M" ~ "Male"</span></span>
+<span id="cb6-50"><a href="#cb6-50"></a><span class="st">  )))'</span>),</span>
+<span id="cb6-51"><a href="#cb6-51"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb6-52"><a href="#cb6-52"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a><span class="st">  labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb6-54"><a href="#cb6-54"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb6-55"><a href="#cb6-55"></a><span class="st">    distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb6-56"><a href="#cb6-56"></a><span class="st">    mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb6-57"><a href="#cb6-57"></a><span class="st">           PARAM = "Overall duration (days)",</span></span>
+<span id="cb6-58"><a href="#cb6-58"></a><span class="st">           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb6-59"><a href="#cb6-59"></a><span class="st">           AVALU = "Days") %&gt;%</span></span>
+<span id="cb6-60"><a href="#cb6-60"></a><span class="st">    bind_rows(ADEX)</span></span>
+<span id="cb6-61"><a href="#cb6-61"></a></span>
+<span id="cb6-62"><a href="#cb6-62"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb6-63"><a href="#cb6-63"></a><span class="st">    mutate(</span></span>
+<span id="cb6-64"><a href="#cb6-64"></a><span class="st">      AGEGR1 = factor(ifelse(AGE &lt; 65, "&lt;65", "&gt;=65")),</span></span>
+<span id="cb6-65"><a href="#cb6-65"></a><span class="st">      AGEGR2 = factor(case_when(</span></span>
+<span id="cb6-66"><a href="#cb6-66"></a><span class="st">        AGE &lt; 18 ~ "&lt; 18",</span></span>
+<span id="cb6-67"><a href="#cb6-67"></a><span class="st">        AGE &gt;= 18 &amp; AGE &lt;= 40 ~ "18 - 40",</span></span>
+<span id="cb6-68"><a href="#cb6-68"></a><span class="st">        AGE &gt; 40 &amp; AGE &lt;= 64 ~ "41 - 64",</span></span>
+<span id="cb6-69"><a href="#cb6-69"></a><span class="st">        TRUE ~ "&gt;=65"</span></span>
+<span id="cb6-70"><a href="#cb6-70"></a><span class="st">      ), levels = c("&lt; 18", "18 - 40", "41 - 64", "&gt;=65")),</span></span>
+<span id="cb6-71"><a href="#cb6-71"></a><span class="st">      SEX = factor(case_when(</span></span>
+<span id="cb6-72"><a href="#cb6-72"></a><span class="st">        SEX == "F" ~ "Female",</span></span>
+<span id="cb6-73"><a href="#cb6-73"></a><span class="st">        SEX == "M" ~ "Male"</span></span>
+<span id="cb6-74"><a href="#cb6-74"></a><span class="st">    )))</span></span>
+<span id="cb6-75"><a href="#cb6-75"></a><span class="st">  var_labels(ADEX) &lt;- c(labels, "Age group (years)", "Age group (years)")'</span>),</span>
+<span id="cb6-76"><a href="#cb6-76"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-77"><a href="#cb6-77"></a>  ),</span>
+<span id="cb6-78"><a href="#cb6-78"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-79"><a href="#cb6-79"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb6-80"><a href="#cb6-80"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb6-81"><a href="#cb6-81"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb6-82"><a href="#cb6-82"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-83"><a href="#cb6-83"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb6-84"><a href="#cb6-84"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb6-85"><a href="#cb6-85"></a>      ),</span>
+<span id="cb6-86"><a href="#cb6-86"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-87"><a href="#cb6-87"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb6-88"><a href="#cb6-88"></a>        <span class="at">selected =</span> <span class="st">"SEX"</span></span>
+<span id="cb6-89"><a href="#cb6-89"></a>      ),</span>
+<span id="cb6-90"><a href="#cb6-90"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-91"><a href="#cb6-91"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AGEGR1"</span>, <span class="st">"AGEGR2"</span>)),</span>
+<span id="cb6-92"><a href="#cb6-92"></a>        <span class="at">selected =</span> <span class="st">"AGEGR1"</span></span>
+<span id="cb6-93"><a href="#cb6-93"></a>      ),</span>
+<span id="cb6-94"><a href="#cb6-94"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-95"><a href="#cb6-95"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb6-96"><a href="#cb6-96"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb6-97"><a href="#cb6-97"></a>      ),</span>
+<span id="cb6-98"><a href="#cb6-98"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb6-99"><a href="#cb6-99"></a>    )</span>
+<span id="cb6-100"><a href="#cb6-100"></a>  ),</span>
+<span id="cb6-101"><a href="#cb6-101"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb6-102"><a href="#cb6-102"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb6-103"><a href="#cb6-103"></a>  )</span>
+<span id="cb6-104"><a href="#cb6-104"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:36:59.4025 pid:13976 token:[] teal.modules.clinical Initializing tm_t_exposure</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="rmpt03_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rmpt03_cache/html/sessioninfo_9f960018bc2064d164675aa9162fa5df">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rmpt03_cache/html/snapshot_374313a06f61bc961be7d99f3d44f9d1">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/risk-management-plan/rmpt03.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/risk-management-plan/rmpt01.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">RMPT01</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/risk-management-plan/rmpt04.html" class="pagination-link">
+        <span class="nav-page-text">RMPT04</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> RMPT03</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Extent of Exposure by Age Group and Gender for Risk Management Plan</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-25"><a href="#cb12-25"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb12-26"><a href="#cb12-26"></a></span>
+<span id="cb12-27"><a href="#cb12-27"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb12-29"><a href="#cb12-29"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-32"><a href="#cb12-32"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb12-34"><a href="#cb12-34"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb12-35"><a href="#cb12-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-36"><a href="#cb12-36"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb12-37"><a href="#cb12-37"></a></span>
+<span id="cb12-38"><a href="#cb12-38"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb12-40"><a href="#cb12-40"></a>  <span class="fu">filter</span>(</span>
+<span id="cb12-41"><a href="#cb12-41"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb12-42"><a href="#cb12-42"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb12-43"><a href="#cb12-43"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb12-44"><a href="#cb12-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-46"><a href="#cb12-46"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(AGE <span class="sc">&lt;</span> <span class="dv">65</span>, <span class="st">"&lt;65"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb12-47"><a href="#cb12-47"></a>    <span class="at">AGEGR2 =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-48"><a href="#cb12-48"></a>      AGE <span class="sc">&lt;</span> <span class="dv">18</span> <span class="sc">~</span> <span class="st">"&lt; 18"</span>,</span>
+<span id="cb12-49"><a href="#cb12-49"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">18</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">40</span> <span class="sc">~</span> <span class="st">"18 - 40"</span>,</span>
+<span id="cb12-50"><a href="#cb12-50"></a>      AGE <span class="sc">&gt;</span> <span class="dv">40</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"41 - 64"</span>,</span>
+<span id="cb12-51"><a href="#cb12-51"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb12-52"><a href="#cb12-52"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 18"</span>, <span class="st">"18 - 40"</span>, <span class="st">"41 - 64"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb12-53"><a href="#cb12-53"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-54"><a href="#cb12-54"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb12-55"><a href="#cb12-55"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb12-56"><a href="#cb12-56"></a>    ))</span>
+<span id="cb12-57"><a href="#cb12-57"></a>  )</span>
+<span id="cb12-58"><a href="#cb12-58"></a></span>
+<span id="cb12-59"><a href="#cb12-59"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a>  <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-61"><a href="#cb12-61"></a>  <span class="fu">mutate</span>(<span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-62"><a href="#cb12-62"></a>    SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb12-63"><a href="#cb12-63"></a>    SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a>  )))</span>
+<span id="cb12-65"><a href="#cb12-65"></a><span class="in">```</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a></span>
+<span id="cb12-67"><a href="#cb12-67"></a><span class="fu">## Standard Table</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a></span>
+<span id="cb12-69"><a href="#cb12-69"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-70"><a href="#cb12-70"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb12-71"><a href="#cb12-71"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Age Group and Gender: Safety-Evaluable Patients"</span>,</span>
+<span id="cb12-72"><a href="#cb12-72"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-74"><a href="#cb12-74"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"Total"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-75"><a href="#cb12-75"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb12-76"><a href="#cb12-76"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-77"><a href="#cb12-77"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb12-78"><a href="#cb12-78"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb12-79"><a href="#cb12-79"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-80"><a href="#cb12-80"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb12-81"><a href="#cb12-81"></a>    <span class="at">var =</span> <span class="st">"AGEGR1"</span>,</span>
+<span id="cb12-82"><a href="#cb12-82"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-84"><a href="#cb12-84"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Age group (years)"</span>))</span>
+<span id="cb12-85"><a href="#cb12-85"></a></span>
+<span id="cb12-86"><a href="#cb12-86"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb12-87"><a href="#cb12-87"></a>result</span>
+<span id="cb12-88"><a href="#cb12-88"></a><span class="in">```</span></span>
+<span id="cb12-89"><a href="#cb12-89"></a></span>
+<span id="cb12-90"><a href="#cb12-90"></a><span class="fu">## Table Excluding Empty Age Groups</span></span>
+<span id="cb12-91"><a href="#cb12-91"></a></span>
+<span id="cb12-92"><a href="#cb12-92"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="at">title =</span> <span class="st">"Duration of Exposure: Safety-Evaluable Patients"</span>,</span>
+<span id="cb12-95"><a href="#cb12-95"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span></span>
+<span id="cb12-96"><a href="#cb12-96"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-97"><a href="#cb12-97"></a>  <span class="fu">split_cols_by</span>(<span class="st">"SEX"</span>, <span class="at">split_fun =</span> <span class="fu">add_overall_level</span>(<span class="st">"Total"</span>, <span class="at">first =</span> <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-98"><a href="#cb12-98"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb12-99"><a href="#cb12-99"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb12-100"><a href="#cb12-100"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Number of Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Patient Time*"</span>),</span>
+<span id="cb12-101"><a href="#cb12-101"></a>    <span class="at">custom_label =</span> <span class="st">"Total Number of Patients and Patient Time"</span></span>
+<span id="cb12-102"><a href="#cb12-102"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb12-104"><a href="#cb12-104"></a>    <span class="at">var =</span> <span class="st">"AGEGR2"</span>,</span>
+<span id="cb12-105"><a href="#cb12-105"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-106"><a href="#cb12-106"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-107"><a href="#cb12-107"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Age group (years)"</span>))</span>
+<span id="cb12-108"><a href="#cb12-108"></a></span>
+<span id="cb12-109"><a href="#cb12-109"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f) <span class="sc">%&gt;%</span></span>
+<span id="cb12-110"><a href="#cb12-110"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb12-111"><a href="#cb12-111"></a>result</span>
+<span id="cb12-112"><a href="#cb12-112"></a><span class="in">```</span></span>
+<span id="cb12-113"><a href="#cb12-113"></a></span>
+<span id="cb12-114"><a href="#cb12-114"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-115"><a href="#cb12-115"></a></span>
+<span id="cb12-116"><a href="#cb12-116"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-117"><a href="#cb12-117"></a></span>
+<span id="cb12-118"><a href="#cb12-118"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-119"><a href="#cb12-119"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb12-120"><a href="#cb12-120"></a></span>
+<span id="cb12-121"><a href="#cb12-121"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-122"><a href="#cb12-122"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-123"><a href="#cb12-123"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-124"><a href="#cb12-124"></a></span>
+<span id="cb12-125"><a href="#cb12-125"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-126"><a href="#cb12-126"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb12-127"><a href="#cb12-127"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb12-128"><a href="#cb12-128"></a></span>
+<span id="cb12-129"><a href="#cb12-129"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb12-130"><a href="#cb12-130"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb12-131"><a href="#cb12-131"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-132"><a href="#cb12-132"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-133"><a href="#cb12-133"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb12-134"><a href="#cb12-134"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb12-135"><a href="#cb12-135"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb12-136"><a href="#cb12-136"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb12-137"><a href="#cb12-137"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-138"><a href="#cb12-138"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb12-139"><a href="#cb12-139"></a></span>
+<span id="cb12-140"><a href="#cb12-140"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb12-141"><a href="#cb12-141"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb12-142"><a href="#cb12-142"></a>    <span class="at">AGEGR1 =</span> <span class="fu">factor</span>(<span class="fu">ifelse</span>(AGE <span class="sc">&lt;</span> <span class="dv">65</span>, <span class="st">"&lt;65"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb12-143"><a href="#cb12-143"></a>    <span class="at">AGEGR2 =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-144"><a href="#cb12-144"></a>      AGE <span class="sc">&lt;</span> <span class="dv">18</span> <span class="sc">~</span> <span class="st">"&lt; 18"</span>,</span>
+<span id="cb12-145"><a href="#cb12-145"></a>      AGE <span class="sc">&gt;=</span> <span class="dv">18</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">40</span> <span class="sc">~</span> <span class="st">"18 - 40"</span>,</span>
+<span id="cb12-146"><a href="#cb12-146"></a>      AGE <span class="sc">&gt;</span> <span class="dv">40</span> <span class="sc">&amp;</span> AGE <span class="sc">&lt;=</span> <span class="dv">64</span> <span class="sc">~</span> <span class="st">"41 - 64"</span>,</span>
+<span id="cb12-147"><a href="#cb12-147"></a>      <span class="cn">TRUE</span> <span class="sc">~</span> <span class="st">"&gt;=65"</span></span>
+<span id="cb12-148"><a href="#cb12-148"></a>    ), <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"&lt; 18"</span>, <span class="st">"18 - 40"</span>, <span class="st">"41 - 64"</span>, <span class="st">"&gt;=65"</span>)),</span>
+<span id="cb12-149"><a href="#cb12-149"></a>    <span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-150"><a href="#cb12-150"></a>      SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb12-151"><a href="#cb12-151"></a>      SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb12-152"><a href="#cb12-152"></a>    ))</span>
+<span id="cb12-153"><a href="#cb12-153"></a>  )</span>
+<span id="cb12-154"><a href="#cb12-154"></a></span>
+<span id="cb12-155"><a href="#cb12-155"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> <span class="fu">c</span>(labels, <span class="st">"Age group (years)"</span>, <span class="st">"Age group (years)"</span>)</span>
+<span id="cb12-156"><a href="#cb12-156"></a></span>
+<span id="cb12-157"><a href="#cb12-157"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb12-158"><a href="#cb12-158"></a>  <span class="fu">mutate</span>(<span class="at">SEX =</span> <span class="fu">factor</span>(<span class="fu">case_when</span>(</span>
+<span id="cb12-159"><a href="#cb12-159"></a>    SEX <span class="sc">==</span> <span class="st">"F"</span> <span class="sc">~</span> <span class="st">"Female"</span>,</span>
+<span id="cb12-160"><a href="#cb12-160"></a>    SEX <span class="sc">==</span> <span class="st">"M"</span> <span class="sc">~</span> <span class="st">"Male"</span></span>
+<span id="cb12-161"><a href="#cb12-161"></a>  )))</span>
+<span id="cb12-162"><a href="#cb12-162"></a></span>
+<span id="cb12-163"><a href="#cb12-163"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-164"><a href="#cb12-164"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-165"><a href="#cb12-165"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")</span></span>
+<span id="cb12-166"><a href="#cb12-166"></a><span class="st">  ADSL &lt;- ADSL %&gt;% filter(ADSL$SAFFL == "Y") %&gt;%</span></span>
+<span id="cb12-167"><a href="#cb12-167"></a><span class="st">  mutate(SEX = factor(case_when(</span></span>
+<span id="cb12-168"><a href="#cb12-168"></a><span class="st">    SEX == "F" ~ "Female",</span></span>
+<span id="cb12-169"><a href="#cb12-169"></a><span class="st">    SEX == "M" ~ "Male"</span></span>
+<span id="cb12-170"><a href="#cb12-170"></a><span class="st">  )))'</span>),</span>
+<span id="cb12-171"><a href="#cb12-171"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb12-172"><a href="#cb12-172"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb12-173"><a href="#cb12-173"></a><span class="st">  labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb12-174"><a href="#cb12-174"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb12-175"><a href="#cb12-175"></a><span class="st">    distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb12-176"><a href="#cb12-176"></a><span class="st">    mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb12-177"><a href="#cb12-177"></a><span class="st">           PARAM = "Overall duration (days)",</span></span>
+<span id="cb12-178"><a href="#cb12-178"></a><span class="st">           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb12-179"><a href="#cb12-179"></a><span class="st">           AVALU = "Days") %&gt;%</span></span>
+<span id="cb12-180"><a href="#cb12-180"></a><span class="st">    bind_rows(ADEX)</span></span>
+<span id="cb12-181"><a href="#cb12-181"></a></span>
+<span id="cb12-182"><a href="#cb12-182"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb12-183"><a href="#cb12-183"></a><span class="st">    mutate(</span></span>
+<span id="cb12-184"><a href="#cb12-184"></a><span class="st">      AGEGR1 = factor(ifelse(AGE &lt; 65, "&lt;65", "&gt;=65")),</span></span>
+<span id="cb12-185"><a href="#cb12-185"></a><span class="st">      AGEGR2 = factor(case_when(</span></span>
+<span id="cb12-186"><a href="#cb12-186"></a><span class="st">        AGE &lt; 18 ~ "&lt; 18",</span></span>
+<span id="cb12-187"><a href="#cb12-187"></a><span class="st">        AGE &gt;= 18 &amp; AGE &lt;= 40 ~ "18 - 40",</span></span>
+<span id="cb12-188"><a href="#cb12-188"></a><span class="st">        AGE &gt; 40 &amp; AGE &lt;= 64 ~ "41 - 64",</span></span>
+<span id="cb12-189"><a href="#cb12-189"></a><span class="st">        TRUE ~ "&gt;=65"</span></span>
+<span id="cb12-190"><a href="#cb12-190"></a><span class="st">      ), levels = c("&lt; 18", "18 - 40", "41 - 64", "&gt;=65")),</span></span>
+<span id="cb12-191"><a href="#cb12-191"></a><span class="st">      SEX = factor(case_when(</span></span>
+<span id="cb12-192"><a href="#cb12-192"></a><span class="st">        SEX == "F" ~ "Female",</span></span>
+<span id="cb12-193"><a href="#cb12-193"></a><span class="st">        SEX == "M" ~ "Male"</span></span>
+<span id="cb12-194"><a href="#cb12-194"></a><span class="st">    )))</span></span>
+<span id="cb12-195"><a href="#cb12-195"></a><span class="st">  var_labels(ADEX) &lt;- c(labels, "Age group (years)", "Age group (years)")'</span>),</span>
+<span id="cb12-196"><a href="#cb12-196"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-197"><a href="#cb12-197"></a>  ),</span>
+<span id="cb12-198"><a href="#cb12-198"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-199"><a href="#cb12-199"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb12-200"><a href="#cb12-200"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb12-201"><a href="#cb12-201"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb12-202"><a href="#cb12-202"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-203"><a href="#cb12-203"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb12-204"><a href="#cb12-204"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb12-205"><a href="#cb12-205"></a>      ),</span>
+<span id="cb12-206"><a href="#cb12-206"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-207"><a href="#cb12-207"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb12-208"><a href="#cb12-208"></a>        <span class="at">selected =</span> <span class="st">"SEX"</span></span>
+<span id="cb12-209"><a href="#cb12-209"></a>      ),</span>
+<span id="cb12-210"><a href="#cb12-210"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-211"><a href="#cb12-211"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"AGEGR1"</span>, <span class="st">"AGEGR2"</span>)),</span>
+<span id="cb12-212"><a href="#cb12-212"></a>        <span class="at">selected =</span> <span class="st">"AGEGR1"</span></span>
+<span id="cb12-213"><a href="#cb12-213"></a>      ),</span>
+<span id="cb12-214"><a href="#cb12-214"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-215"><a href="#cb12-215"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb12-216"><a href="#cb12-216"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb12-217"><a href="#cb12-217"></a>      ),</span>
+<span id="cb12-218"><a href="#cb12-218"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-219"><a href="#cb12-219"></a>    )</span>
+<span id="cb12-220"><a href="#cb12-220"></a>  ),</span>
+<span id="cb12-221"><a href="#cb12-221"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb12-222"><a href="#cb12-222"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb12-223"><a href="#cb12-223"></a>  )</span>
+<span id="cb12-224"><a href="#cb12-224"></a>)</span>
+<span id="cb12-225"><a href="#cb12-225"></a></span>
+<span id="cb12-226"><a href="#cb12-226"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-227"><a href="#cb12-227"></a><span class="in">```</span></span>
+<span id="cb12-228"><a href="#cb12-228"></a></span>
+<span id="cb12-229"><a href="#cb12-229"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-230"><a href="#cb12-230"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+++ b/stable/tables/risk-management-plan/rmpt04.html
@@ -0,0 +1,2245 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog - RMPT04</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
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+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
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+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
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+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+<script src="../../site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="../../site_libs/clipboard/clipboard.min.js"></script>
+<script src="../../site_libs/quarto-search/autocomplete.umd.js"></script>
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+<script src="../../site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="../../">
+<link href="../../tables/risk-management-plan/rmpt05.html" rel="next">
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+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RMPT04</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Extent of Exposure by Ethnic Origin for Risk Management Plan</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="rmpt04_cache/html/setup_4728995d63aa34913d507d440d36f9d4">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  )</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rmpt04_cache/html/variant1_d5c3e5e7aab6e100b1d711657f3cd962">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Ethnic Origin: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"ETHNIC"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-9"><a href="#cb2-9"></a>    <span class="at">add_total_level =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">custom_label =</span> <span class="st">"Total"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Ethnicity"</span>))</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb2-15"><a href="#cb2-15"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Extent of Exposure by Ethnic Origin: Safety-Evaluable Patients
+
+——————————————————————————————————————————————————
+                          Patients     Person time
+Ethnicity                  (N=400)       (N=400)  
+——————————————————————————————————————————————————
+NOT REPORTED              18 (4.5%)       2085    
+HISPANIC OR LATINO        28 (7.0%)       2423    
+NOT HISPANIC OR LATINO   165 (41.2%)      15570   
+UNKNOWN                   6 (1.5%)         563    
+Total                    217 (54.2%)      20641   
+——————————————————————————————————————————————————
+
+* Patient Time is the sum of exposure across all patients in days.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="rmpt04_cache/html/teal_4294115106fb598b0bc268c6f391e1c2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a></span>
+<span id="cb4-8"><a href="#cb4-8"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb4-9"><a href="#cb4-9"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb4-18"><a href="#cb4-18"></a></span>
+<span id="cb4-19"><a href="#cb4-19"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb4-23"><a href="#cb4-23"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a><span class="st">  distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a><span class="st">  mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a><span class="st">         PARAM = "Overall duration (days)",</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a><span class="st">         AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a><span class="st">         AVALU = "Days") %&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a><span class="st">  bind_rows(ADEX)'</span>),</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>  ),</span>
+<span id="cb4-33"><a href="#cb4-33"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-34"><a href="#cb4-34"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb4-35"><a href="#cb4-35"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb4-36"><a href="#cb4-36"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb4-37"><a href="#cb4-37"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-39"><a href="#cb4-39"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb4-40"><a href="#cb4-40"></a>      ),</span>
+<span id="cb4-41"><a href="#cb4-41"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>)),</span>
+<span id="cb4-43"><a href="#cb4-43"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb4-44"><a href="#cb4-44"></a>      ),</span>
+<span id="cb4-45"><a href="#cb4-45"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-46"><a href="#cb4-46"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ETHNIC"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb4-47"><a href="#cb4-47"></a>        <span class="at">selected =</span> <span class="st">"ETHNIC"</span></span>
+<span id="cb4-48"><a href="#cb4-48"></a>      ),</span>
+<span id="cb4-49"><a href="#cb4-49"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-50"><a href="#cb4-50"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb4-51"><a href="#cb4-51"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb4-52"><a href="#cb4-52"></a>      ),</span>
+<span id="cb4-53"><a href="#cb4-53"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-54"><a href="#cb4-54"></a>    )</span>
+<span id="cb4-55"><a href="#cb4-55"></a>  ),</span>
+<span id="cb4-56"><a href="#cb4-56"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb4-57"><a href="#cb4-57"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-58"><a href="#cb4-58"></a>  )</span>
+<span id="cb4-59"><a href="#cb4-59"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:36:02.8990 pid:13780 token:[] teal.modules.clinical Initializing tm_t_exposure</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="rmpt04_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rmpt04_cache/html/sessioninfo_be6cac852dc7b093cd16b05094a3c84d">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rmpt04_cache/html/snapshot_a2a35fe6c7500665771b07a40078afb4">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/risk-management-plan/rmpt04.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
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+      }
+    } else {
+      return undefined;
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+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
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+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/risk-management-plan/rmpt03.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">RMPT03</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/risk-management-plan/rmpt05.html" class="pagination-link">
+        <span class="nav-page-text">RMPT05</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> RMPT04</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Extent of Exposure by Ethnic Origin for Risk Management Plan</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in sample scda dataset.</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb10-44"><a href="#cb10-44"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  )</span>
+<span id="cb10-46"><a href="#cb10-46"></a></span>
+<span id="cb10-47"><a href="#cb10-47"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-48"><a href="#cb10-48"></a><span class="in">```</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a></span>
+<span id="cb10-50"><a href="#cb10-50"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a></span>
+<span id="cb10-52"><a href="#cb10-52"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Ethnic Origin: Safety-Evaluable Patients"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="at">main_footer =</span> <span class="st">"* Patient Time is the sum of exposure across all patients in days."</span>,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-58"><a href="#cb10-58"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="at">var =</span> <span class="st">"ETHNIC"</span>,</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-61"><a href="#cb10-61"></a>    <span class="at">add_total_level =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-62"><a href="#cb10-62"></a>    <span class="at">custom_label =</span> <span class="st">"Total"</span></span>
+<span id="cb10-63"><a href="#cb10-63"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-64"><a href="#cb10-64"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="st">"Ethnicity"</span>))</span>
+<span id="cb10-65"><a href="#cb10-65"></a></span>
+<span id="cb10-66"><a href="#cb10-66"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb10-67"><a href="#cb10-67"></a>result</span>
+<span id="cb10-68"><a href="#cb10-68"></a><span class="in">```</span></span>
+<span id="cb10-69"><a href="#cb10-69"></a></span>
+<span id="cb10-70"><a href="#cb10-70"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-73"><a href="#cb10-73"></a></span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a></span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-78"><a href="#cb10-78"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-80"><a href="#cb10-80"></a></span>
+<span id="cb10-81"><a href="#cb10-81"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-82"><a href="#cb10-82"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-83"><a href="#cb10-83"></a></span>
+<span id="cb10-84"><a href="#cb10-84"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb10-85"><a href="#cb10-85"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-86"><a href="#cb10-86"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-87"><a href="#cb10-87"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-88"><a href="#cb10-88"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-89"><a href="#cb10-89"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-90"><a href="#cb10-90"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb10-91"><a href="#cb10-91"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb10-92"><a href="#cb10-92"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-93"><a href="#cb10-93"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-94"><a href="#cb10-94"></a></span>
+<span id="cb10-95"><a href="#cb10-95"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-96"><a href="#cb10-96"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-97"><a href="#cb10-97"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-98"><a href="#cb10-98"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex, <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb10-101"><a href="#cb10-101"></a><span class="st">  distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb10-102"><a href="#cb10-102"></a><span class="st">  mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb10-103"><a href="#cb10-103"></a><span class="st">         PARAM = "Overall duration (days)",</span></span>
+<span id="cb10-104"><a href="#cb10-104"></a><span class="st">         AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a><span class="st">         AVALU = "Days") %&gt;%</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a><span class="st">  bind_rows(ADEX)'</span>),</span>
+<span id="cb10-107"><a href="#cb10-107"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a>  ),</span>
+<span id="cb10-109"><a href="#cb10-109"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-110"><a href="#cb10-110"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb10-111"><a href="#cb10-111"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb10-112"><a href="#cb10-112"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb10-113"><a href="#cb10-113"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-114"><a href="#cb10-114"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-115"><a href="#cb10-115"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb10-116"><a href="#cb10-116"></a>      ),</span>
+<span id="cb10-117"><a href="#cb10-117"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-118"><a href="#cb10-118"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>)),</span>
+<span id="cb10-119"><a href="#cb10-119"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb10-120"><a href="#cb10-120"></a>      ),</span>
+<span id="cb10-121"><a href="#cb10-121"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-122"><a href="#cb10-122"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ETHNIC"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb10-123"><a href="#cb10-123"></a>        <span class="at">selected =</span> <span class="st">"ETHNIC"</span></span>
+<span id="cb10-124"><a href="#cb10-124"></a>      ),</span>
+<span id="cb10-125"><a href="#cb10-125"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-126"><a href="#cb10-126"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb10-127"><a href="#cb10-127"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb10-128"><a href="#cb10-128"></a>      ),</span>
+<span id="cb10-129"><a href="#cb10-129"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-130"><a href="#cb10-130"></a>    )</span>
+<span id="cb10-131"><a href="#cb10-131"></a>  ),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb10-133"><a href="#cb10-133"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-134"><a href="#cb10-134"></a>  )</span>
+<span id="cb10-135"><a href="#cb10-135"></a>)</span>
+<span id="cb10-136"><a href="#cb10-136"></a></span>
+<span id="cb10-137"><a href="#cb10-137"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-138"><a href="#cb10-138"></a><span class="in">```</span></span>
+<span id="cb10-139"><a href="#cb10-139"></a></span>
+<span id="cb10-140"><a href="#cb10-140"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-141"><a href="#cb10-141"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
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+
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
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+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
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+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
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+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RMPT05</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Extent of Exposure by Race for Risk Management Plan</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="rmpt05_cache/html/setup_cf4ada5fd745a0624d7bd750448d7ec0">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb1-11"><a href="#cb1-11"></a></span>
+<span id="cb1-12"><a href="#cb1-12"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in the sample dataset.</span></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="fu">set.seed</span>(<span class="dv">1</span>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">mutate</span>()</span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rmpt05_cache/html/variant1_2b603f8cb6346820a96ce08893dfb6b8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Race: Safety-Evaluable Patients"</span>,</span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="at">main_footer =</span> <span class="st">"* Person time is the sum of exposure across all patients in unit: days."</span>,</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Person time*"</span>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    <span class="at">var =</span> <span class="st">"RACE"</span>,</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-13"><a href="#cb2-13"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-14"><a href="#cb2-14"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="fu">obj_label</span>(adex<span class="sc">$</span>RACE)))</span>
+<span id="cb2-15"><a href="#cb2-15"></a></span>
+<span id="cb2-16"><a href="#cb2-16"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb2-17"><a href="#cb2-17"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Extent of Exposure by Race: Safety-Evaluable Patients
+
+————————————————————————————————————————————————————————————————————————
+                                               Patients     Person time*
+Race                                            (N=400)       (N=400)   
+————————————————————————————————————————————————————————————————————————
+Total patients numbers/person time            217 (54.2%)      20641    
+  ASIAN                                       113 (28.2%)      10239    
+  BLACK OR AFRICAN AMERICAN                   48 (12.0%)        4481    
+  WHITE                                       40 (10.0%)        4237    
+  AMERICAN INDIAN OR ALASKA NATIVE             14 (3.5%)        1566    
+  MULTIPLE                                     1 (0.2%)          58     
+  NATIVE HAWAIIAN OR OTHER PACIFIC ISLANDER    1 (0.2%)          60     
+  OTHER                                        0 (0.0%)          0      
+  UNKNOWN                                      0 (0.0%)          0      
+————————————————————————————————————————————————————————————————————————
+
+* Person time is the sum of exposure across all patients in unit: days.</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="rmpt05_cache/html/teal_759a9887a5a324228afda9787555baa5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb4-10"><a href="#cb4-10"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-12"><a href="#cb4-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb4-14"><a href="#cb4-14"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb4-15"><a href="#cb4-15"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb4-16"><a href="#cb4-16"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb4-19"><a href="#cb4-19"></a></span>
+<span id="cb4-20"><a href="#cb4-20"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> labels</span>
+<span id="cb4-21"><a href="#cb4-21"></a></span>
+<span id="cb4-22"><a href="#cb4-22"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-23"><a href="#cb4-23"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-24"><a href="#cb4-24"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb4-25"><a href="#cb4-25"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex,</span>
+<span id="cb4-26"><a href="#cb4-26"></a>      <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a><span class="st">  labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a><span class="st">    distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a><span class="st">    mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a><span class="st">           PARAM = "Overall duration (days)",</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a><span class="st">           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a><span class="st">           AVALU = "Days") %&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a><span class="st">    bind_rows(ADEX)</span></span>
+<span id="cb4-36"><a href="#cb4-36"></a><span class="st">  var_labels(ADEX) &lt;- labels'</span></span>
+<span id="cb4-37"><a href="#cb4-37"></a>    ),</span>
+<span id="cb4-38"><a href="#cb4-38"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a>  ),</span>
+<span id="cb4-40"><a href="#cb4-40"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-41"><a href="#cb4-41"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb4-42"><a href="#cb4-42"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb4-43"><a href="#cb4-43"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb4-44"><a href="#cb4-44"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-45"><a href="#cb4-45"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-46"><a href="#cb4-46"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb4-47"><a href="#cb4-47"></a>      ),</span>
+<span id="cb4-48"><a href="#cb4-48"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-49"><a href="#cb4-49"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb4-50"><a href="#cb4-50"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb4-51"><a href="#cb4-51"></a>      ),</span>
+<span id="cb4-52"><a href="#cb4-52"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-53"><a href="#cb4-53"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb4-54"><a href="#cb4-54"></a>        <span class="at">selected =</span> <span class="st">"RACE"</span></span>
+<span id="cb4-55"><a href="#cb4-55"></a>      ),</span>
+<span id="cb4-56"><a href="#cb4-56"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-57"><a href="#cb4-57"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb4-58"><a href="#cb4-58"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb4-59"><a href="#cb4-59"></a>      ),</span>
+<span id="cb4-60"><a href="#cb4-60"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb4-61"><a href="#cb4-61"></a>    )</span>
+<span id="cb4-62"><a href="#cb4-62"></a>  ),</span>
+<span id="cb4-63"><a href="#cb4-63"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb4-64"><a href="#cb4-64"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb4-65"><a href="#cb4-65"></a>  )</span>
+<span id="cb4-66"><a href="#cb4-66"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:35:35.9803 pid:13682 token:[] teal.modules.clinical Initializing tm_t_exposure</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="rmpt05_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rmpt05_cache/html/sessioninfo_ccd1f643ddec4d29cc72aa4058e1ca6f">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rmpt05_cache/html/snapshot_a115903f39edca8ccddd0170224270eb">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/risk-management-plan/rmpt05.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
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+      <a href="../../tables/risk-management-plan/rmpt04.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">RMPT04</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/risk-management-plan/rmpt06.html" class="pagination-link">
+        <span class="nav-page-text">RMPT06</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> RMPT05</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Extent of Exposure by Race for Risk Management Plan</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a></span>
+<span id="cb10-20"><a href="#cb10-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-21"><a href="#cb10-21"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a></span>
+<span id="cb10-23"><a href="#cb10-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-24"><a href="#cb10-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>adex <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adex)</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="co"># Simulate ADEX records with PARAMCD == "TDURD" as they are not in the sample dataset.</span></span>
+<span id="cb10-28"><a href="#cb10-28"></a><span class="fu">set.seed</span>(<span class="dv">1</span>)</span>
+<span id="cb10-29"><a href="#cb10-29"></a>adex2 <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-34"><a href="#cb10-34"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-35"><a href="#cb10-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-37"><a href="#cb10-37"></a></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="co"># Now pre-processing steps are carried out.</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a>anl <span class="ot">&lt;-</span> adex2 <span class="sc">%&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-41"><a href="#cb10-41"></a>    PARAMCD <span class="sc">==</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-42"><a href="#cb10-42"></a>    PARCAT2 <span class="sc">==</span> <span class="st">"Drug A"</span>,</span>
+<span id="cb10-43"><a href="#cb10-43"></a>    SAFFL <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">mutate</span>()</span>
+<span id="cb10-46"><a href="#cb10-46"></a></span>
+<span id="cb10-47"><a href="#cb10-47"></a>adsl_f <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span> <span class="fu">filter</span>(adsl<span class="sc">$</span>SAFFL <span class="sc">==</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-48"><a href="#cb10-48"></a><span class="in">```</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a></span>
+<span id="cb10-50"><a href="#cb10-50"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-51"><a href="#cb10-51"></a></span>
+<span id="cb10-52"><a href="#cb10-52"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(</span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="at">title =</span> <span class="st">"Extent of Exposure by Race: Safety-Evaluable Patients"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="at">main_footer =</span> <span class="st">"* Person time is the sum of exposure across all patients in unit: days."</span>,</span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="at">show_colcounts =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-57"><a href="#cb10-57"></a>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-58"><a href="#cb10-58"></a>  <span class="fu">summarize_patients_exposure_in_cols</span>(</span>
+<span id="cb10-59"><a href="#cb10-59"></a>    <span class="at">var =</span> <span class="st">"AVAL"</span>, <span class="at">col_split =</span> <span class="cn">TRUE</span>,</span>
+<span id="cb10-60"><a href="#cb10-60"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">n_patients =</span> <span class="st">"Patients"</span>, <span class="at">sum_exposure =</span> <span class="st">"Person time*"</span>)</span>
+<span id="cb10-61"><a href="#cb10-61"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a>  <span class="fu">analyze_patients_exposure_in_cols</span>(</span>
+<span id="cb10-63"><a href="#cb10-63"></a>    <span class="at">var =</span> <span class="st">"RACE"</span>,</span>
+<span id="cb10-64"><a href="#cb10-64"></a>    <span class="at">col_split =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-65"><a href="#cb10-65"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a>  <span class="fu">append_topleft</span>(<span class="fu">c</span>(<span class="st">""</span>, <span class="fu">obj_label</span>(adex<span class="sc">$</span>RACE)))</span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, <span class="at">df =</span> anl, <span class="at">alt_counts_df =</span> adsl_f)</span>
+<span id="cb10-69"><a href="#cb10-69"></a>result</span>
+<span id="cb10-70"><a href="#cb10-70"></a><span class="in">```</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a></span>
+<span id="cb10-72"><a href="#cb10-72"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-73"><a href="#cb10-73"></a></span>
+<span id="cb10-74"><a href="#cb10-74"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-75"><a href="#cb10-75"></a></span>
+<span id="cb10-76"><a href="#cb10-76"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-77"><a href="#cb10-77"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb10-78"><a href="#cb10-78"></a></span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-80"><a href="#cb10-80"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-81"><a href="#cb10-81"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-84"><a href="#cb10-84"></a>adex <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adex"</span>)</span>
+<span id="cb10-85"><a href="#cb10-85"></a>labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adex)</span>
+<span id="cb10-86"><a href="#cb10-86"></a></span>
+<span id="cb10-87"><a href="#cb10-87"></a><span class="fu">set.seed</span>(<span class="dv">1</span>, <span class="at">kind =</span> <span class="st">"Mersenne-Twister"</span>)</span>
+<span id="cb10-88"><a href="#cb10-88"></a>adex <span class="ot">&lt;-</span> adex <span class="sc">%&gt;%</span></span>
+<span id="cb10-89"><a href="#cb10-89"></a>  <span class="fu">distinct</span>(USUBJID, <span class="at">.keep_all =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-90"><a href="#cb10-90"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-91"><a href="#cb10-91"></a>    <span class="at">PARAMCD =</span> <span class="st">"TDURD"</span>,</span>
+<span id="cb10-92"><a href="#cb10-92"></a>    <span class="at">PARAM =</span> <span class="st">"Overall duration (days)"</span>,</span>
+<span id="cb10-93"><a href="#cb10-93"></a>    <span class="at">AVAL =</span> <span class="fu">sample</span>(<span class="at">x =</span> <span class="fu">seq</span>(<span class="dv">1</span>, <span class="dv">200</span>), <span class="at">size =</span> <span class="fu">n</span>(), <span class="at">replace =</span> <span class="cn">TRUE</span>),</span>
+<span id="cb10-94"><a href="#cb10-94"></a>    <span class="at">AVALU =</span> <span class="st">"Days"</span></span>
+<span id="cb10-95"><a href="#cb10-95"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-96"><a href="#cb10-96"></a>  <span class="fu">bind_rows</span>(adex)</span>
+<span id="cb10-97"><a href="#cb10-97"></a></span>
+<span id="cb10-98"><a href="#cb10-98"></a><span class="fu">var_labels</span>(adex) <span class="ot">&lt;-</span> labels</span>
+<span id="cb10-99"><a href="#cb10-99"></a></span>
+<span id="cb10-100"><a href="#cb10-100"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-101"><a href="#cb10-101"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-102"><a href="#cb10-102"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb10-103"><a href="#cb10-103"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADEX"</span>, adex,</span>
+<span id="cb10-104"><a href="#cb10-104"></a>      <span class="at">code =</span> <span class="st">'ADEX &lt;- synthetic_cdisc_dataset("latest", "adex")</span></span>
+<span id="cb10-105"><a href="#cb10-105"></a><span class="st">  labels &lt;- var_labels(ADEX)</span></span>
+<span id="cb10-106"><a href="#cb10-106"></a><span class="st">  set.seed(1, kind = "Mersenne-Twister")</span></span>
+<span id="cb10-107"><a href="#cb10-107"></a><span class="st">  ADEX &lt;- ADEX %&gt;%</span></span>
+<span id="cb10-108"><a href="#cb10-108"></a><span class="st">    distinct(USUBJID, .keep_all = TRUE) %&gt;%</span></span>
+<span id="cb10-109"><a href="#cb10-109"></a><span class="st">    mutate(PARAMCD = "TDURD",</span></span>
+<span id="cb10-110"><a href="#cb10-110"></a><span class="st">           PARAM = "Overall duration (days)",</span></span>
+<span id="cb10-111"><a href="#cb10-111"></a><span class="st">           AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE),</span></span>
+<span id="cb10-112"><a href="#cb10-112"></a><span class="st">           AVALU = "Days") %&gt;%</span></span>
+<span id="cb10-113"><a href="#cb10-113"></a><span class="st">    bind_rows(ADEX)</span></span>
+<span id="cb10-114"><a href="#cb10-114"></a><span class="st">  var_labels(ADEX) &lt;- labels'</span></span>
+<span id="cb10-115"><a href="#cb10-115"></a>    ),</span>
+<span id="cb10-116"><a href="#cb10-116"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-117"><a href="#cb10-117"></a>  ),</span>
+<span id="cb10-118"><a href="#cb10-118"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-119"><a href="#cb10-119"></a>    <span class="fu">tm_t_exposure</span>(</span>
+<span id="cb10-120"><a href="#cb10-120"></a>      <span class="at">label =</span> <span class="st">"Duration of Exposure Table"</span>,</span>
+<span id="cb10-121"><a href="#cb10-121"></a>      <span class="at">dataname =</span> <span class="st">"ADEX"</span>,</span>
+<span id="cb10-122"><a href="#cb10-122"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-123"><a href="#cb10-123"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-124"><a href="#cb10-124"></a>        <span class="at">selected =</span> <span class="st">"TDURD"</span></span>
+<span id="cb10-125"><a href="#cb10-125"></a>      ),</span>
+<span id="cb10-126"><a href="#cb10-126"></a>      <span class="at">col_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-127"><a href="#cb10-127"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"SEX"</span>, <span class="st">"ARM"</span>)),</span>
+<span id="cb10-128"><a href="#cb10-128"></a>        <span class="at">selected =</span> <span class="cn">NULL</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a>      ),</span>
+<span id="cb10-130"><a href="#cb10-130"></a>      <span class="at">row_by_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-131"><a href="#cb10-131"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adex, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"RACE"</span>, <span class="st">"STRATA1"</span>, <span class="st">"SEX"</span>)),</span>
+<span id="cb10-132"><a href="#cb10-132"></a>        <span class="at">selected =</span> <span class="st">"RACE"</span></span>
+<span id="cb10-133"><a href="#cb10-133"></a>      ),</span>
+<span id="cb10-134"><a href="#cb10-134"></a>      <span class="at">parcat =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-135"><a href="#cb10-135"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(adex, <span class="st">"PARCAT2"</span>),</span>
+<span id="cb10-136"><a href="#cb10-136"></a>        <span class="at">selected =</span> <span class="st">"Drug A"</span></span>
+<span id="cb10-137"><a href="#cb10-137"></a>      ),</span>
+<span id="cb10-138"><a href="#cb10-138"></a>      <span class="at">add_total =</span> <span class="cn">FALSE</span></span>
+<span id="cb10-139"><a href="#cb10-139"></a>    )</span>
+<span id="cb10-140"><a href="#cb10-140"></a>  ),</span>
+<span id="cb10-141"><a href="#cb10-141"></a>  <span class="at">filter =</span> <span class="fu">list</span>(</span>
+<span id="cb10-142"><a href="#cb10-142"></a>    <span class="at">ADSL =</span> <span class="fu">list</span>(<span class="at">SAFFL =</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-143"><a href="#cb10-143"></a>  )</span>
+<span id="cb10-144"><a href="#cb10-144"></a>)</span>
+<span id="cb10-145"><a href="#cb10-145"></a></span>
+<span id="cb10-146"><a href="#cb10-146"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-147"><a href="#cb10-147"></a><span class="in">```</span></span>
+<span id="cb10-148"><a href="#cb10-148"></a></span>
+<span id="cb10-149"><a href="#cb10-149"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-150"><a href="#cb10-150"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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+ <span class="menu-text">AET01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
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+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
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+          <li class="sidebar-item">
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+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
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+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">RMPT06</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Seriousness, Outcomes, Severity, Frequency with 95% CI for Risk Management Plan</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">Table Selecting <br> Sections to Display</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Table with Differences</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Table Modifying Alpha Level and <br> Type of Confidence Interval</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false">Table by SMQ</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-8-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-8" role="tab" aria-controls="tabset-1-8" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<p>The <code>adae</code> and <code>adsl</code> datasets need to undergo data processing before table production. Some new variables are added to these datasets to create the desired tables.</p>
+<div class="cell" data-hash="rmpt06_cache/html/setup_e53f6fc10f3e2fba4f94766005211fa9">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(</span>
+<span id="cb1-11"><a href="#cb1-11"></a>  adae,</span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01SC"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"SMQ02SC"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb1-13"><a href="#cb1-13"></a>)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>df_max <span class="ot">&lt;-</span> <span class="fu">aggregate</span>(<span class="fu">as.numeric</span>(AETOXGR) <span class="sc">~</span> USUBJID, <span class="at">data =</span> adae, <span class="at">FUN =</span> max, <span class="at">drop =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a><span class="fu">colnames</span>(df_max) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"WTOXGR"</span>)</span>
+<span id="cb1-17"><a href="#cb1-17"></a></span>
+<span id="cb1-18"><a href="#cb1-18"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  <span class="fu">left_join</span>(df_max, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">WTOXGR =</span> <span class="fu">factor</span>(WTOXGR, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>)),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">fl_ser =</span> AESER <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">WTOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb1-26"><a href="#cb1-26"></a>      WTOXGR,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb1-28"><a href="#cb1-28"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb1-29"><a href="#cb1-29"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb1-30"><a href="#cb1-30"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb1-31"><a href="#cb1-31"></a>      <span class="st">"Grade 5"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>    ),</span>
+<span id="cb1-33"><a href="#cb1-33"></a>    <span class="at">AEOUT =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb1-34"><a href="#cb1-34"></a>      AEOUT,</span>
+<span id="cb1-35"><a href="#cb1-35"></a>      <span class="st">"Fatal outcome"</span> <span class="ot">=</span> <span class="st">"FATAL"</span>,</span>
+<span id="cb1-36"><a href="#cb1-36"></a>      <span class="st">"Unresolved"</span> <span class="ot">=</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span>,</span>
+<span id="cb1-37"><a href="#cb1-37"></a>      <span class="st">"Recovered/Resolved"</span> <span class="ot">=</span> <span class="st">"RECOVERED/RESOLVED"</span>,</span>
+<span id="cb1-38"><a href="#cb1-38"></a>      <span class="st">"Resolved with sequelae"</span> <span class="ot">=</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>,</span>
+<span id="cb1-39"><a href="#cb1-39"></a>      <span class="st">"Recovering/Resolving"</span> <span class="ot">=</span> <span class="st">"RECOVERING/RESOLVING"</span>,</span>
+<span id="cb1-40"><a href="#cb1-40"></a>      <span class="st">"Unknown outcome"</span> <span class="ot">=</span> <span class="st">"UNKNOWN"</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>    )</span>
+<span id="cb1-42"><a href="#cb1-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-44"><a href="#cb1-44"></a>    <span class="at">WTOXGR =</span> <span class="st">"Worst overall grade"</span>,</span>
+<span id="cb1-45"><a href="#cb1-45"></a>    <span class="at">fl_ser =</span> <span class="st">"Number of patients with at least one serious AE"</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  )</span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a><span class="co"># Add AE flag to adsl.</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a>adsl1 <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-50"><a href="#cb1-50"></a>  <span class="fu">mutate</span>(<span class="at">AEFL =</span> <span class="fu">ifelse</span>(USUBJID <span class="sc">%in%</span> adae<span class="sc">$</span>USUBJID, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a>  <span class="fu">var_relabel</span>(<span class="at">AEFL =</span> <span class="st">"At least one AE"</span>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<p>Please note that by default the percentage analysis uses Wald’s confidence interval with continuity correction and the default confidence interval for percentage is 95%. To use a different method for confidence interval calculation, the method name needs to be provided to <code>method</code> argument.</p>
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="rmpt06_cache/html/variant1_863580dd8f5e82503c37c8d2a057442e">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb2-4"><a href="#cb2-4"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb2-5"><a href="#cb2-5"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb2-7"><a href="#cb2-7"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb2-8"><a href="#cb2-8"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>    ),</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  )</span>
+<span id="cb2-12"><a href="#cb2-12"></a></span>
+<span id="cb2-13"><a href="#cb2-13"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb2-14"><a href="#cb2-14"></a></span>
+<span id="cb2-15"><a href="#cb2-15"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb2-24"><a href="#cb2-24"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-25"><a href="#cb2-25"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-26"><a href="#cb2-26"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb2-27"><a href="#cb2-27"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb2-28"><a href="#cb2-28"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb2-31"><a href="#cb2-31"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb2-33"><a href="#cb2-33"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-34"><a href="#cb2-34"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb2-35"><a href="#cb2-35"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb2-36"><a href="#cb2-36"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb2-37"><a href="#cb2-37"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb2-38"><a href="#cb2-38"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb2-39"><a href="#cb2-39"></a>  )</span>
+<span id="cb2-40"><a href="#cb2-40"></a></span>
+<span id="cb2-41"><a href="#cb2-41"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-42"><a href="#cb2-42"></a></span>
+<span id="cb2-43"><a href="#cb2-43"></a><span class="co"># Combine tables.</span></span>
+<span id="cb2-44"><a href="#cb2-44"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb2-45"><a href="#cb2-45"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb2-46"><a href="#cb2-46"></a>  result_adsl,</span>
+<span id="cb2-47"><a href="#cb2-47"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb2-48"><a href="#cb2-48"></a>)</span>
+<span id="cb2-49"><a href="#cb2-49"></a></span>
+<span id="cb2-50"><a href="#cb2-50"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                   A: Drug X      B: Placebo    C: Combination
+                                                                    (N=134)        (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Number of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  
+95% CI for % of patients with at least one AE (Clopper-Pearson)   (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) 
+Total number of AEs                                                   609            622             703      
+Number of patients with at least one AE by worst grade                                                        
+  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   
+  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   
+  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  
+  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  
+  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  
+Number of patients with at least one serious AE                   104 (85.2%)    101 (82.1%)      99 (82.5%)  
+Number of patients with at least one AE by outcome                                                            
+  Fatal outcome                                                    76 (62.3%)     70 (56.9%)      75 (62.5%)  
+  Unresolved                                                       66 (54.1%)     64 (52.0%)      70 (58.3%)  
+  Recovered/Resolved                                               73 (59.8%)     83 (67.5%)      88 (73.3%)  
+  Resolved with sequelae                                           44 (36.1%)     40 (32.5%)      43 (35.8%)  
+  Recovering/Resolving                                             81 (66.4%)     84 (68.3%)      88 (73.3%)  
+  Unknown outcome                                                  38 (31.1%)     49 (39.8%)      44 (36.7%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="rmpt06_cache/html/variant2_99ab2c289fe9aa91005216453597c0dc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb4-4"><a href="#cb4-4"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb4-5"><a href="#cb4-5"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb4-7"><a href="#cb4-7"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb4-8"><a href="#cb4-8"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>    ),</span>
+<span id="cb4-10"><a href="#cb4-10"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  )</span>
+<span id="cb4-12"><a href="#cb4-12"></a></span>
+<span id="cb4-13"><a href="#cb4-13"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb4-14"><a href="#cb4-14"></a></span>
+<span id="cb4-15"><a href="#cb4-15"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb4-16"><a href="#cb4-16"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb4-19"><a href="#cb4-19"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb4-20"><a href="#cb4-20"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb4-21"><a href="#cb4-21"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb4-22"><a href="#cb4-22"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb4-23"><a href="#cb4-23"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb4-26"><a href="#cb4-26"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb4-27"><a href="#cb4-27"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb4-28"><a href="#cb4-28"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb4-29"><a href="#cb4-29"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-30"><a href="#cb4-30"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb4-31"><a href="#cb4-31"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb4-32"><a href="#cb4-32"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb4-33"><a href="#cb4-33"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  )</span>
+<span id="cb4-35"><a href="#cb4-35"></a></span>
+<span id="cb4-36"><a href="#cb4-36"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-37"><a href="#cb4-37"></a></span>
+<span id="cb4-38"><a href="#cb4-38"></a><span class="co"># Combine tables.</span></span>
+<span id="cb4-39"><a href="#cb4-39"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb4-40"><a href="#cb4-40"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb4-41"><a href="#cb4-41"></a>  result_adsl,</span>
+<span id="cb4-42"><a href="#cb4-42"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb4-43"><a href="#cb4-43"></a>)</span>
+<span id="cb4-44"><a href="#cb4-44"></a></span>
+<span id="cb4-45"><a href="#cb4-45"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                   A: Drug X      B: Placebo    C: Combination
+                                                                    (N=134)        (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Number of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  
+95% CI for % of patients with at least one AE (Clopper-Pearson)   (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) 
+Total number of AEs                                                   609            622             703      
+Number of patients with at least one AE by worst grade                                                        
+  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   
+  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   
+  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  
+  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  
+  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  
+Number of patients with at least one serious AE                   104 (77.6%)    101 (75.4%)      99 (75.0%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<p>Please note that by default the percentage difference analysis also uses Wald’s confidence interval with continuity correction and the default confidence interval is 95%.</p>
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="rmpt06_cache/html/variant3_999bf083db7c2c2d7e1213fbc5db0149">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb6-4"><a href="#cb6-4"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb6-5"><a href="#cb6-5"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb6-6"><a href="#cb6-6"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-7"><a href="#cb6-7"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb6-8"><a href="#cb6-8"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE"</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>    ),</span>
+<span id="cb6-10"><a href="#cb6-10"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb6-11"><a href="#cb6-11"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb6-14"><a href="#cb6-14"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb6-15"><a href="#cb6-15"></a>      <span class="at">diff =</span> <span class="st">"Difference in % of patients with at least one AE"</span>,</span>
+<span id="cb6-16"><a href="#cb6-16"></a>      <span class="at">diff_ci =</span> <span class="st">"95% CI of difference (Wald, with correction)"</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>    ),</span>
+<span id="cb6-18"><a href="#cb6-18"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb6-19"><a href="#cb6-19"></a>  )</span>
+<span id="cb6-20"><a href="#cb6-20"></a></span>
+<span id="cb6-21"><a href="#cb6-21"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb6-22"><a href="#cb6-22"></a></span>
+<span id="cb6-23"><a href="#cb6-23"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb6-24"><a href="#cb6-24"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-26"><a href="#cb6-26"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb6-27"><a href="#cb6-27"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb6-28"><a href="#cb6-28"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb6-30"><a href="#cb6-30"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb6-32"><a href="#cb6-32"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-33"><a href="#cb6-33"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb6-34"><a href="#cb6-34"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb6-35"><a href="#cb6-35"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb6-36"><a href="#cb6-36"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb6-37"><a href="#cb6-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb6-39"><a href="#cb6-39"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb6-40"><a href="#cb6-40"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb6-41"><a href="#cb6-41"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb6-42"><a href="#cb6-42"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb6-43"><a href="#cb6-43"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb6-44"><a href="#cb6-44"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb6-45"><a href="#cb6-45"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb6-46"><a href="#cb6-46"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb6-47"><a href="#cb6-47"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb6-48"><a href="#cb6-48"></a>  )</span>
+<span id="cb6-49"><a href="#cb6-49"></a></span>
+<span id="cb6-50"><a href="#cb6-50"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb6-51"><a href="#cb6-51"></a></span>
+<span id="cb6-52"><a href="#cb6-52"></a><span class="co"># Combine tables.</span></span>
+<span id="cb6-53"><a href="#cb6-53"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb6-54"><a href="#cb6-54"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb6-55"><a href="#cb6-55"></a>  result_adsl,</span>
+<span id="cb6-56"><a href="#cb6-56"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb6-57"><a href="#cb6-57"></a>)</span>
+<span id="cb6-58"><a href="#cb6-58"></a></span>
+<span id="cb6-59"><a href="#cb6-59"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                          A: Drug X      B: Placebo    C: Combination
+                                                           (N=134)        (N=134)         (N=132)    
+—————————————————————————————————————————————————————————————————————————————————————————————————————
+Number of patients with at least one adverse event       122 (91.0%)    123 (91.8%)     120 (90.9%)  
+95% CI for % of patients with at least one AE            (84.9, 95.3)   (85.8, 95.8)    (84.7, 95.2) 
+Difference in % of patients with at least one AE                            0.7             -0.1     
+  95% CI of difference (Wald, with correction)                          (-6.7, 8.2)     (-7.8, 7.5)  
+Total number of AEs                                          609            622             703      
+Number of patients with at least one AE by worst grade                                               
+  Grade 1                                                  7 (5.2%)       9 (6.7%)        4 (3.0%)   
+  Grade 2                                                  6 (4.5%)      10 (7.5%)        7 (5.3%)   
+  Grade 3                                                 18 (13.4%)     14 (10.4%)      16 (12.1%)  
+  Grade 4                                                 15 (11.2%)     20 (14.9%)      18 (13.6%)  
+  Grade 5                                                 76 (56.7%)     70 (52.2%)      75 (56.8%)  
+Number of patients with at least one serious AE          104 (77.6%)    101 (75.4%)      99 (75.0%)  
+Number of patients with at least one AE by outcome                                                   
+  Fatal outcome                                           76 (62.3%)     70 (56.9%)      75 (62.5%)  
+  Unresolved                                              66 (54.1%)     64 (52.0%)      70 (58.3%)  
+  Recovered/Resolved                                      73 (59.8%)     83 (67.5%)      88 (73.3%)  
+  Resolved with sequelae                                  44 (36.1%)     40 (32.5%)      43 (35.8%)  
+  Recovering/Resolving                                    81 (66.4%)     84 (68.3%)      88 (73.3%)  
+  Unknown outcome                                         38 (31.1%)     49 (39.8%)      44 (36.7%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<p>The confidence level can be changed through the <code>conf_level</code> argument.</p>
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="rmpt06_cache/html/variant4_4e5d9a3df18adf6bbd45777aa5f4bd1d">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb8-4"><a href="#cb8-4"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb8-5"><a href="#cb8-5"></a>    <span class="at">conf_level =</span> <span class="fl">0.90</span>,</span>
+<span id="cb8-6"><a href="#cb8-6"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb8-7"><a href="#cb8-7"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-8"><a href="#cb8-8"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb8-9"><a href="#cb8-9"></a>      <span class="at">prop_ci =</span> <span class="st">"90% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>    ),</span>
+<span id="cb8-11"><a href="#cb8-11"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb8-12"><a href="#cb8-12"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-13"><a href="#cb8-13"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb8-14"><a href="#cb8-14"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb8-15"><a href="#cb8-15"></a>    <span class="at">conf_level =</span> <span class="fl">0.90</span>,</span>
+<span id="cb8-16"><a href="#cb8-16"></a>    <span class="at">method =</span> <span class="st">"newcombe"</span>,</span>
+<span id="cb8-17"><a href="#cb8-17"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb8-18"><a href="#cb8-18"></a>      <span class="at">diff =</span> <span class="st">"Difference in % of patients with at least one AE"</span>,</span>
+<span id="cb8-19"><a href="#cb8-19"></a>      <span class="at">diff_ci =</span> <span class="st">"90% CI of difference (Newcombe)"</span></span>
+<span id="cb8-20"><a href="#cb8-20"></a>    ),</span>
+<span id="cb8-21"><a href="#cb8-21"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb8-22"><a href="#cb8-22"></a>  )</span>
+<span id="cb8-23"><a href="#cb8-23"></a></span>
+<span id="cb8-24"><a href="#cb8-24"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb8-25"><a href="#cb8-25"></a></span>
+<span id="cb8-26"><a href="#cb8-26"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb8-27"><a href="#cb8-27"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-28"><a href="#cb8-28"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-29"><a href="#cb8-29"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb8-30"><a href="#cb8-30"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb8-31"><a href="#cb8-31"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb8-32"><a href="#cb8-32"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb8-33"><a href="#cb8-33"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb8-34"><a href="#cb8-34"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb8-35"><a href="#cb8-35"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-36"><a href="#cb8-36"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb8-37"><a href="#cb8-37"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb8-38"><a href="#cb8-38"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb8-39"><a href="#cb8-39"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-40"><a href="#cb8-40"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-41"><a href="#cb8-41"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb8-42"><a href="#cb8-42"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb8-43"><a href="#cb8-43"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb8-44"><a href="#cb8-44"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb8-45"><a href="#cb8-45"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb8-46"><a href="#cb8-46"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb8-47"><a href="#cb8-47"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb8-48"><a href="#cb8-48"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb8-49"><a href="#cb8-49"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb8-50"><a href="#cb8-50"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb8-51"><a href="#cb8-51"></a>  )</span>
+<span id="cb8-52"><a href="#cb8-52"></a></span>
+<span id="cb8-53"><a href="#cb8-53"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb8-54"><a href="#cb8-54"></a></span>
+<span id="cb8-55"><a href="#cb8-55"></a><span class="co"># Combine tables.</span></span>
+<span id="cb8-56"><a href="#cb8-56"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb8-57"><a href="#cb8-57"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb8-58"><a href="#cb8-58"></a>  result_adsl,</span>
+<span id="cb8-59"><a href="#cb8-59"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb8-60"><a href="#cb8-60"></a>)</span>
+<span id="cb8-61"><a href="#cb8-61"></a></span>
+<span id="cb8-62"><a href="#cb8-62"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                                                   A: Drug X      B: Placebo    C: Combination
+                                                                    (N=134)        (N=134)         (N=132)    
+——————————————————————————————————————————————————————————————————————————————————————————————————————————————
+Number of patients with at least one adverse event                122 (91.0%)    123 (91.8%)     120 (90.9%)  
+90% CI for % of patients with at least one AE (Clopper-Pearson)   (85.9, 94.8)   (86.8, 95.3)    (85.7, 94.7) 
+Difference in % of patients with at least one AE                                     0.7             -0.1     
+  90% CI of difference (Newcombe)                                                (-5.1, 6.6)     (-6.1, 5.8)  
+Total number of AEs                                                   609            622             703      
+Number of patients with at least one AE by worst grade                                                        
+  Grade 1                                                           7 (5.2%)       9 (6.7%)        4 (3.0%)   
+  Grade 2                                                           6 (4.5%)      10 (7.5%)        7 (5.3%)   
+  Grade 3                                                          18 (13.4%)     14 (10.4%)      16 (12.1%)  
+  Grade 4                                                          15 (11.2%)     20 (14.9%)      18 (13.6%)  
+  Grade 5                                                          76 (56.7%)     70 (52.2%)      75 (56.8%)  
+Number of patients with at least one serious AE                   104 (77.6%)    101 (75.4%)      99 (75.0%)  
+Number of patients with at least one AE by outcome                                                            
+  Fatal outcome                                                    76 (62.3%)     70 (56.9%)      75 (62.5%)  
+  Unresolved                                                       66 (54.1%)     64 (52.0%)      70 (58.3%)  
+  Recovered/Resolved                                               73 (59.8%)     83 (67.5%)      88 (73.3%)  
+  Resolved with sequelae                                           44 (36.1%)     40 (32.5%)      43 (35.8%)  
+  Recovering/Resolving                                             81 (66.4%)     84 (68.3%)      88 (73.3%)  
+  Unknown outcome                                                  38 (31.1%)     49 (39.8%)      44 (36.7%)  </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<div class="cell" data-hash="rmpt06_cache/html/unnamed-chunk-1_b50590f15900a5ae4cf1c0e4c00b1148">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-hash="rmpt06_cache/html/teal_1eb53abbeda4c8de09f0beac292a9fa3">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a><span class="co"># In progress</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-8" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-8-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="rmpt06_cache/html/sessioninfo_f9d107ef6ad4e776b26e27851cfc4675">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+[1] scda_0.1.6       dplyr_1.1.3      tern_0.9.0       rtables_0.6.3   
+[5] magrittr_2.0.3   formatters_0.5.2
+
+loaded via a namespace (and not attached):
+ [1] Matrix_1.6-1.1    gtable_0.3.4      jsonlite_1.8.7    compiler_4.3.1   
+ [5] brio_1.1.3        tidyselect_1.2.0  tidyr_1.3.0       splines_4.3.1    
+ [9] scales_1.2.1      yaml_2.3.7        fastmap_1.1.1     lattice_0.21-8   
+[13] ggplot2_3.4.3     R6_2.5.1          generics_0.1.3    knitr_1.44       
+[17] forcats_1.0.0     rbibutils_2.2.15  htmlwidgets_1.6.2 backports_1.4.1  
+[21] checkmate_2.2.0   tibble_3.2.1      munsell_0.5.0     pillar_1.9.0     
+[25] rlang_1.1.1       utf8_1.2.3        testthat_3.1.10   broom_1.0.5      
+[29] xfun_0.40         cli_3.6.1         Rdpack_2.5        digest_0.6.33    
+[33] grid_4.3.1        rstudioapi_0.15.0 lifecycle_1.0.3   vctrs_0.6.3      
+[37] evaluate_0.21     glue_1.6.2        codetools_0.2-19  survival_3.5-7   
+[41] fansi_1.0.4       colorspace_2.1-0  purrr_1.0.2       rmarkdown_2.25   
+[45] tools_4.3.1       pkgconfig_2.0.3   htmltools_0.5.6  </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="rmpt06_cache/html/snapshot_dd8e5355d44cca3ba8781a336b953cd2">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb14"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb14-1"><a href="#cb14-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-2"><a href="#cb14-2"></a></span>
+<span id="cb14-3"><a href="#cb14-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb14-4"><a href="#cb14-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb14-5"><a href="#cb14-5"></a></span>
+<span id="cb14-6"><a href="#cb14-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb14-7"><a href="#cb14-7"></a></span>
+<span id="cb14-8"><a href="#cb14-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb14-9"><a href="#cb14-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb14-10"><a href="#cb14-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb14-11"><a href="#cb14-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/risk-management-plan/rmpt06.lock">Download</a></p>
+</section>
+</div>
+</div>
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
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+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><nav class="page-navigation column-page-right"><div class="nav-page nav-page-previous">
+      <a href="../../tables/risk-management-plan/rmpt05.html" class="pagination-link">
+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">RMPT05</span>
+      </a>          
+  </div>
+  <div class="nav-page nav-page-next">
+      <a href="../../tables/safety/enrollment01.html" class="pagination-link">
+        <span class="nav-page-text">ENTXX</span> <i class="bi bi-arrow-right-short"></i>
+      </a>
+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb15" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb15-1"><a href="#cb15-1"></a><span class="co">---</span></span>
+<span id="cb15-2"><a href="#cb15-2"></a><span class="an">title:</span><span class="co"> RMPT06</span></span>
+<span id="cb15-3"><a href="#cb15-3"></a><span class="an">subtitle:</span><span class="co"> Seriousness, Outcomes, Severity, Frequency with 95% CI for Risk Management Plan</span></span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="co">---</span></span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>------------------------------------------------------------------------</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb15-9"><a href="#cb15-9"></a></span>
+<span id="cb15-10"><a href="#cb15-10"></a>::: panel-tabset</span>
+<span id="cb15-11"><a href="#cb15-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb15-12"><a href="#cb15-12"></a></span>
+<span id="cb15-13"><a href="#cb15-13"></a>The <span class="in">`adae`</span> and <span class="in">`adsl`</span> datasets need to undergo data processing before table production.</span>
+<span id="cb15-14"><a href="#cb15-14"></a>Some new variables are added to these datasets to create the desired tables.</span>
+<span id="cb15-15"><a href="#cb15-15"></a></span>
+<span id="cb15-16"><a href="#cb15-16"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb15-17"><a href="#cb15-17"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-18"><a href="#cb15-18"></a></span>
+<span id="cb15-19"><a href="#cb15-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb15-20"><a href="#cb15-20"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb15-21"><a href="#cb15-21"></a><span class="fu">library</span>(scda)</span>
+<span id="cb15-22"><a href="#cb15-22"></a></span>
+<span id="cb15-23"><a href="#cb15-23"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb15-24"><a href="#cb15-24"></a>adae <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adae"</span>)</span>
+<span id="cb15-25"><a href="#cb15-25"></a></span>
+<span id="cb15-26"><a href="#cb15-26"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb15-27"><a href="#cb15-27"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb15-28"><a href="#cb15-28"></a>adae <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(</span>
+<span id="cb15-29"><a href="#cb15-29"></a>  adae,</span>
+<span id="cb15-30"><a href="#cb15-30"></a>  <span class="at">omit_columns =</span> <span class="fu">c</span>(<span class="st">"SMQ01NAM"</span>, <span class="st">"SMQ01SC"</span>, <span class="st">"SMQ02NAM"</span>, <span class="st">"SMQ02SC"</span>, <span class="st">"CQ01NAM"</span>, <span class="st">"STUDYID"</span>, <span class="st">"USUBJID"</span>)</span>
+<span id="cb15-31"><a href="#cb15-31"></a>)</span>
+<span id="cb15-32"><a href="#cb15-32"></a></span>
+<span id="cb15-33"><a href="#cb15-33"></a>df_max <span class="ot">&lt;-</span> <span class="fu">aggregate</span>(<span class="fu">as.numeric</span>(AETOXGR) <span class="sc">~</span> USUBJID, <span class="at">data =</span> adae, <span class="at">FUN =</span> max, <span class="at">drop =</span> <span class="cn">FALSE</span>)</span>
+<span id="cb15-34"><a href="#cb15-34"></a><span class="fu">colnames</span>(df_max) <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>, <span class="st">"WTOXGR"</span>)</span>
+<span id="cb15-35"><a href="#cb15-35"></a></span>
+<span id="cb15-36"><a href="#cb15-36"></a>adae <span class="ot">&lt;-</span> adae <span class="sc">%&gt;%</span></span>
+<span id="cb15-37"><a href="#cb15-37"></a>  <span class="fu">left_join</span>(df_max, <span class="at">by =</span> <span class="fu">c</span>(<span class="st">"USUBJID"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-38"><a href="#cb15-38"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb15-39"><a href="#cb15-39"></a>    <span class="at">WTOXGR =</span> <span class="fu">factor</span>(WTOXGR, <span class="at">levels =</span> <span class="fu">c</span>(<span class="st">"1"</span>, <span class="st">"2"</span>, <span class="st">"3"</span>, <span class="st">"4"</span>, <span class="st">"5"</span>)),</span>
+<span id="cb15-40"><a href="#cb15-40"></a>    <span class="at">fl_ser =</span> AESER <span class="sc">==</span> <span class="st">"Y"</span></span>
+<span id="cb15-41"><a href="#cb15-41"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-42"><a href="#cb15-42"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb15-43"><a href="#cb15-43"></a>    <span class="at">WTOXGR =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb15-44"><a href="#cb15-44"></a>      WTOXGR,</span>
+<span id="cb15-45"><a href="#cb15-45"></a>      <span class="st">"Grade 1"</span> <span class="ot">=</span> <span class="st">"1"</span>,</span>
+<span id="cb15-46"><a href="#cb15-46"></a>      <span class="st">"Grade 2"</span> <span class="ot">=</span> <span class="st">"2"</span>,</span>
+<span id="cb15-47"><a href="#cb15-47"></a>      <span class="st">"Grade 3"</span> <span class="ot">=</span> <span class="st">"3"</span>,</span>
+<span id="cb15-48"><a href="#cb15-48"></a>      <span class="st">"Grade 4"</span> <span class="ot">=</span> <span class="st">"4"</span>,</span>
+<span id="cb15-49"><a href="#cb15-49"></a>      <span class="st">"Grade 5"</span> <span class="ot">=</span> <span class="st">"5"</span></span>
+<span id="cb15-50"><a href="#cb15-50"></a>    ),</span>
+<span id="cb15-51"><a href="#cb15-51"></a>    <span class="at">AEOUT =</span> forcats<span class="sc">::</span><span class="fu">fct_recode</span>(</span>
+<span id="cb15-52"><a href="#cb15-52"></a>      AEOUT,</span>
+<span id="cb15-53"><a href="#cb15-53"></a>      <span class="st">"Fatal outcome"</span> <span class="ot">=</span> <span class="st">"FATAL"</span>,</span>
+<span id="cb15-54"><a href="#cb15-54"></a>      <span class="st">"Unresolved"</span> <span class="ot">=</span> <span class="st">"NOT RECOVERED/NOT RESOLVED"</span>,</span>
+<span id="cb15-55"><a href="#cb15-55"></a>      <span class="st">"Recovered/Resolved"</span> <span class="ot">=</span> <span class="st">"RECOVERED/RESOLVED"</span>,</span>
+<span id="cb15-56"><a href="#cb15-56"></a>      <span class="st">"Resolved with sequelae"</span> <span class="ot">=</span> <span class="st">"RECOVERED/RESOLVED WITH SEQUELAE"</span>,</span>
+<span id="cb15-57"><a href="#cb15-57"></a>      <span class="st">"Recovering/Resolving"</span> <span class="ot">=</span> <span class="st">"RECOVERING/RESOLVING"</span>,</span>
+<span id="cb15-58"><a href="#cb15-58"></a>      <span class="st">"Unknown outcome"</span> <span class="ot">=</span> <span class="st">"UNKNOWN"</span></span>
+<span id="cb15-59"><a href="#cb15-59"></a>    )</span>
+<span id="cb15-60"><a href="#cb15-60"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-61"><a href="#cb15-61"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb15-62"><a href="#cb15-62"></a>    <span class="at">WTOXGR =</span> <span class="st">"Worst overall grade"</span>,</span>
+<span id="cb15-63"><a href="#cb15-63"></a>    <span class="at">fl_ser =</span> <span class="st">"Number of patients with at least one serious AE"</span></span>
+<span id="cb15-64"><a href="#cb15-64"></a>  )</span>
+<span id="cb15-65"><a href="#cb15-65"></a></span>
+<span id="cb15-66"><a href="#cb15-66"></a><span class="co"># Add AE flag to adsl.</span></span>
+<span id="cb15-67"><a href="#cb15-67"></a>adsl1 <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb15-68"><a href="#cb15-68"></a>  <span class="fu">mutate</span>(<span class="at">AEFL =</span> <span class="fu">ifelse</span>(USUBJID <span class="sc">%in%</span> adae<span class="sc">$</span>USUBJID, <span class="cn">TRUE</span>, <span class="cn">FALSE</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb15-69"><a href="#cb15-69"></a>  <span class="fu">var_relabel</span>(<span class="at">AEFL =</span> <span class="st">"At least one AE"</span>)</span>
+<span id="cb15-70"><a href="#cb15-70"></a><span class="in">```</span></span>
+<span id="cb15-71"><a href="#cb15-71"></a></span>
+<span id="cb15-72"><a href="#cb15-72"></a><span class="fu">## Standard Table</span></span>
+<span id="cb15-73"><a href="#cb15-73"></a></span>
+<span id="cb15-74"><a href="#cb15-74"></a>Please note that by default the percentage analysis uses Wald's confidence interval with continuity correction and the default confidence interval for percentage is 95%.</span>
+<span id="cb15-75"><a href="#cb15-75"></a>To use a different method for confidence interval calculation, the method name needs to be provided to <span class="in">`method`</span> argument.</span>
+<span id="cb15-76"><a href="#cb15-76"></a></span>
+<span id="cb15-77"><a href="#cb15-77"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb15-78"><a href="#cb15-78"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-79"><a href="#cb15-79"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-80"><a href="#cb15-80"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb15-81"><a href="#cb15-81"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-82"><a href="#cb15-82"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb15-83"><a href="#cb15-83"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-84"><a href="#cb15-84"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb15-85"><a href="#cb15-85"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb15-86"><a href="#cb15-86"></a>    ),</span>
+<span id="cb15-87"><a href="#cb15-87"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb15-88"><a href="#cb15-88"></a>  )</span>
+<span id="cb15-89"><a href="#cb15-89"></a></span>
+<span id="cb15-90"><a href="#cb15-90"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb15-91"><a href="#cb15-91"></a></span>
+<span id="cb15-92"><a href="#cb15-92"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb15-93"><a href="#cb15-93"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-94"><a href="#cb15-94"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-95"><a href="#cb15-95"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb15-96"><a href="#cb15-96"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb15-97"><a href="#cb15-97"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb15-98"><a href="#cb15-98"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb15-99"><a href="#cb15-99"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb15-100"><a href="#cb15-100"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb15-101"><a href="#cb15-101"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-102"><a href="#cb15-102"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-103"><a href="#cb15-103"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb15-104"><a href="#cb15-104"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb15-105"><a href="#cb15-105"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-106"><a href="#cb15-106"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-107"><a href="#cb15-107"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb15-108"><a href="#cb15-108"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-109"><a href="#cb15-109"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span></span>
+<span id="cb15-110"><a href="#cb15-110"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-111"><a href="#cb15-111"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-112"><a href="#cb15-112"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb15-113"><a href="#cb15-113"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb15-114"><a href="#cb15-114"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb15-115"><a href="#cb15-115"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-116"><a href="#cb15-116"></a>  )</span>
+<span id="cb15-117"><a href="#cb15-117"></a></span>
+<span id="cb15-118"><a href="#cb15-118"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb15-119"><a href="#cb15-119"></a></span>
+<span id="cb15-120"><a href="#cb15-120"></a><span class="co"># Combine tables.</span></span>
+<span id="cb15-121"><a href="#cb15-121"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb15-122"><a href="#cb15-122"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb15-123"><a href="#cb15-123"></a>  result_adsl,</span>
+<span id="cb15-124"><a href="#cb15-124"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb15-125"><a href="#cb15-125"></a>)</span>
+<span id="cb15-126"><a href="#cb15-126"></a></span>
+<span id="cb15-127"><a href="#cb15-127"></a>result</span>
+<span id="cb15-128"><a href="#cb15-128"></a><span class="in">```</span></span>
+<span id="cb15-129"><a href="#cb15-129"></a></span>
+<span id="cb15-130"><a href="#cb15-130"></a><span class="fu">## Table Selecting &lt;br/&gt; Sections to Display</span></span>
+<span id="cb15-131"><a href="#cb15-131"></a></span>
+<span id="cb15-132"><a href="#cb15-132"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb15-133"><a href="#cb15-133"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-134"><a href="#cb15-134"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-135"><a href="#cb15-135"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb15-136"><a href="#cb15-136"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-137"><a href="#cb15-137"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb15-138"><a href="#cb15-138"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-139"><a href="#cb15-139"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb15-140"><a href="#cb15-140"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb15-141"><a href="#cb15-141"></a>    ),</span>
+<span id="cb15-142"><a href="#cb15-142"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb15-143"><a href="#cb15-143"></a>  )</span>
+<span id="cb15-144"><a href="#cb15-144"></a></span>
+<span id="cb15-145"><a href="#cb15-145"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb15-146"><a href="#cb15-146"></a></span>
+<span id="cb15-147"><a href="#cb15-147"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb15-148"><a href="#cb15-148"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-149"><a href="#cb15-149"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-150"><a href="#cb15-150"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb15-151"><a href="#cb15-151"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb15-152"><a href="#cb15-152"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb15-153"><a href="#cb15-153"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb15-154"><a href="#cb15-154"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb15-155"><a href="#cb15-155"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb15-156"><a href="#cb15-156"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-157"><a href="#cb15-157"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-158"><a href="#cb15-158"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb15-159"><a href="#cb15-159"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb15-160"><a href="#cb15-160"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-161"><a href="#cb15-161"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-162"><a href="#cb15-162"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb15-163"><a href="#cb15-163"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-164"><a href="#cb15-164"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb15-165"><a href="#cb15-165"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb15-166"><a href="#cb15-166"></a>  )</span>
+<span id="cb15-167"><a href="#cb15-167"></a></span>
+<span id="cb15-168"><a href="#cb15-168"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb15-169"><a href="#cb15-169"></a></span>
+<span id="cb15-170"><a href="#cb15-170"></a><span class="co"># Combine tables.</span></span>
+<span id="cb15-171"><a href="#cb15-171"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb15-172"><a href="#cb15-172"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb15-173"><a href="#cb15-173"></a>  result_adsl,</span>
+<span id="cb15-174"><a href="#cb15-174"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb15-175"><a href="#cb15-175"></a>)</span>
+<span id="cb15-176"><a href="#cb15-176"></a></span>
+<span id="cb15-177"><a href="#cb15-177"></a>result</span>
+<span id="cb15-178"><a href="#cb15-178"></a><span class="in">```</span></span>
+<span id="cb15-179"><a href="#cb15-179"></a></span>
+<span id="cb15-180"><a href="#cb15-180"></a><span class="fu">## Table with Differences</span></span>
+<span id="cb15-181"><a href="#cb15-181"></a></span>
+<span id="cb15-182"><a href="#cb15-182"></a>Please note that by default the percentage difference analysis also uses Wald's confidence interval with continuity correction and the default confidence interval is 95%.</span>
+<span id="cb15-183"><a href="#cb15-183"></a></span>
+<span id="cb15-184"><a href="#cb15-184"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb15-185"><a href="#cb15-185"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-186"><a href="#cb15-186"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-187"><a href="#cb15-187"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb15-188"><a href="#cb15-188"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-189"><a href="#cb15-189"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb15-190"><a href="#cb15-190"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-191"><a href="#cb15-191"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb15-192"><a href="#cb15-192"></a>      <span class="at">prop_ci =</span> <span class="st">"95% CI for % of patients with at least one AE"</span></span>
+<span id="cb15-193"><a href="#cb15-193"></a>    ),</span>
+<span id="cb15-194"><a href="#cb15-194"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb15-195"><a href="#cb15-195"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-196"><a href="#cb15-196"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb15-197"><a href="#cb15-197"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-198"><a href="#cb15-198"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-199"><a href="#cb15-199"></a>      <span class="at">diff =</span> <span class="st">"Difference in % of patients with at least one AE"</span>,</span>
+<span id="cb15-200"><a href="#cb15-200"></a>      <span class="at">diff_ci =</span> <span class="st">"95% CI of difference (Wald, with correction)"</span></span>
+<span id="cb15-201"><a href="#cb15-201"></a>    ),</span>
+<span id="cb15-202"><a href="#cb15-202"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb15-203"><a href="#cb15-203"></a>  )</span>
+<span id="cb15-204"><a href="#cb15-204"></a></span>
+<span id="cb15-205"><a href="#cb15-205"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb15-206"><a href="#cb15-206"></a></span>
+<span id="cb15-207"><a href="#cb15-207"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb15-208"><a href="#cb15-208"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-209"><a href="#cb15-209"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-210"><a href="#cb15-210"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb15-211"><a href="#cb15-211"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb15-212"><a href="#cb15-212"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb15-213"><a href="#cb15-213"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb15-214"><a href="#cb15-214"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb15-215"><a href="#cb15-215"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb15-216"><a href="#cb15-216"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-217"><a href="#cb15-217"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-218"><a href="#cb15-218"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb15-219"><a href="#cb15-219"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb15-220"><a href="#cb15-220"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-221"><a href="#cb15-221"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-222"><a href="#cb15-222"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb15-223"><a href="#cb15-223"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-224"><a href="#cb15-224"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb15-225"><a href="#cb15-225"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb15-226"><a href="#cb15-226"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-227"><a href="#cb15-227"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-228"><a href="#cb15-228"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb15-229"><a href="#cb15-229"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb15-230"><a href="#cb15-230"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb15-231"><a href="#cb15-231"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-232"><a href="#cb15-232"></a>  )</span>
+<span id="cb15-233"><a href="#cb15-233"></a></span>
+<span id="cb15-234"><a href="#cb15-234"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb15-235"><a href="#cb15-235"></a></span>
+<span id="cb15-236"><a href="#cb15-236"></a><span class="co"># Combine tables.</span></span>
+<span id="cb15-237"><a href="#cb15-237"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb15-238"><a href="#cb15-238"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb15-239"><a href="#cb15-239"></a>  result_adsl,</span>
+<span id="cb15-240"><a href="#cb15-240"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb15-241"><a href="#cb15-241"></a>)</span>
+<span id="cb15-242"><a href="#cb15-242"></a></span>
+<span id="cb15-243"><a href="#cb15-243"></a>result</span>
+<span id="cb15-244"><a href="#cb15-244"></a><span class="in">```</span></span>
+<span id="cb15-245"><a href="#cb15-245"></a></span>
+<span id="cb15-246"><a href="#cb15-246"></a><span class="fu">## Table Modifying Alpha Level and &lt;br/&gt; Type of Confidence Interval</span></span>
+<span id="cb15-247"><a href="#cb15-247"></a></span>
+<span id="cb15-248"><a href="#cb15-248"></a>The confidence level can be changed through the <span class="in">`conf_level`</span> argument.</span>
+<span id="cb15-249"><a href="#cb15-249"></a></span>
+<span id="cb15-250"><a href="#cb15-250"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb15-251"><a href="#cb15-251"></a>lyt_adsl <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-252"><a href="#cb15-252"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>, <span class="at">ref_group =</span> <span class="st">"A: Drug X"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-253"><a href="#cb15-253"></a>  <span class="fu">estimate_proportion</span>(</span>
+<span id="cb15-254"><a href="#cb15-254"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-255"><a href="#cb15-255"></a>    <span class="at">conf_level =</span> <span class="fl">0.90</span>,</span>
+<span id="cb15-256"><a href="#cb15-256"></a>    <span class="at">method =</span> <span class="st">"clopper-pearson"</span>,</span>
+<span id="cb15-257"><a href="#cb15-257"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-258"><a href="#cb15-258"></a>      <span class="at">n_prop =</span> <span class="st">"Number of patients with at least one adverse event"</span>,</span>
+<span id="cb15-259"><a href="#cb15-259"></a>      <span class="at">prop_ci =</span> <span class="st">"90% CI for % of patients with at least one AE (Clopper-Pearson)"</span></span>
+<span id="cb15-260"><a href="#cb15-260"></a>    ),</span>
+<span id="cb15-261"><a href="#cb15-261"></a>    <span class="at">table_names =</span> <span class="st">"est_prop"</span></span>
+<span id="cb15-262"><a href="#cb15-262"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-263"><a href="#cb15-263"></a>  <span class="fu">estimate_proportion_diff</span>(</span>
+<span id="cb15-264"><a href="#cb15-264"></a>    <span class="at">vars =</span> <span class="st">"AEFL"</span>,</span>
+<span id="cb15-265"><a href="#cb15-265"></a>    <span class="at">conf_level =</span> <span class="fl">0.90</span>,</span>
+<span id="cb15-266"><a href="#cb15-266"></a>    <span class="at">method =</span> <span class="st">"newcombe"</span>,</span>
+<span id="cb15-267"><a href="#cb15-267"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(</span>
+<span id="cb15-268"><a href="#cb15-268"></a>      <span class="at">diff =</span> <span class="st">"Difference in % of patients with at least one AE"</span>,</span>
+<span id="cb15-269"><a href="#cb15-269"></a>      <span class="at">diff_ci =</span> <span class="st">"90% CI of difference (Newcombe)"</span></span>
+<span id="cb15-270"><a href="#cb15-270"></a>    ),</span>
+<span id="cb15-271"><a href="#cb15-271"></a>    <span class="at">table_names =</span> <span class="st">"est_prop_diff"</span></span>
+<span id="cb15-272"><a href="#cb15-272"></a>  )</span>
+<span id="cb15-273"><a href="#cb15-273"></a></span>
+<span id="cb15-274"><a href="#cb15-274"></a>result_adsl <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adsl, <span class="at">df =</span> adsl1, <span class="at">alt_counts_df =</span> adsl1)</span>
+<span id="cb15-275"><a href="#cb15-275"></a></span>
+<span id="cb15-276"><a href="#cb15-276"></a><span class="co"># Layout for variables from adae dataset.</span></span>
+<span id="cb15-277"><a href="#cb15-277"></a>lyt_adae <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-278"><a href="#cb15-278"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb15-279"><a href="#cb15-279"></a>  <span class="fu">count_values</span>(</span>
+<span id="cb15-280"><a href="#cb15-280"></a>    <span class="st">"STUDYID"</span>,</span>
+<span id="cb15-281"><a href="#cb15-281"></a>    <span class="at">values =</span> <span class="fu">as.character</span>(<span class="fu">unique</span>(adae<span class="sc">$</span>STUDYID)),</span>
+<span id="cb15-282"><a href="#cb15-282"></a>    <span class="at">.stats =</span> <span class="st">"count"</span>,</span>
+<span id="cb15-283"><a href="#cb15-283"></a>    <span class="at">.labels =</span> <span class="fu">c</span>(<span class="at">count =</span> <span class="st">"Total number of AEs"</span>),</span>
+<span id="cb15-284"><a href="#cb15-284"></a>    <span class="at">table_names =</span> <span class="st">"total_aes"</span></span>
+<span id="cb15-285"><a href="#cb15-285"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-286"><a href="#cb15-286"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-287"><a href="#cb15-287"></a>    <span class="st">"WTOXGR"</span>,</span>
+<span id="cb15-288"><a href="#cb15-288"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by worst grade"</span>,</span>
+<span id="cb15-289"><a href="#cb15-289"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-290"><a href="#cb15-290"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-291"><a href="#cb15-291"></a>  <span class="fu">count_patients_with_flags</span>(</span>
+<span id="cb15-292"><a href="#cb15-292"></a>    <span class="st">"USUBJID"</span>,</span>
+<span id="cb15-293"><a href="#cb15-293"></a>    <span class="at">flag_variables =</span> <span class="st">"fl_ser"</span>,</span>
+<span id="cb15-294"><a href="#cb15-294"></a>    <span class="at">denom =</span> <span class="st">"N_col"</span></span>
+<span id="cb15-295"><a href="#cb15-295"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb15-296"><a href="#cb15-296"></a>  <span class="fu">count_occurrences</span>(</span>
+<span id="cb15-297"><a href="#cb15-297"></a>    <span class="st">"AEOUT"</span>,</span>
+<span id="cb15-298"><a href="#cb15-298"></a>    <span class="at">denom =</span> <span class="st">"n"</span>,</span>
+<span id="cb15-299"><a href="#cb15-299"></a>    <span class="at">var_labels =</span> <span class="st">"Number of patients with at least one AE by outcome"</span>,</span>
+<span id="cb15-300"><a href="#cb15-300"></a>    <span class="at">show_labels =</span> <span class="st">"visible"</span></span>
+<span id="cb15-301"><a href="#cb15-301"></a>  )</span>
+<span id="cb15-302"><a href="#cb15-302"></a></span>
+<span id="cb15-303"><a href="#cb15-303"></a>result_adae <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt_adae, <span class="at">df =</span> adae, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb15-304"><a href="#cb15-304"></a></span>
+<span id="cb15-305"><a href="#cb15-305"></a><span class="co"># Combine tables.</span></span>
+<span id="cb15-306"><a href="#cb15-306"></a><span class="fu">col_info</span>(result_adsl) <span class="ot">&lt;-</span> <span class="fu">col_info</span>(result_adae)</span>
+<span id="cb15-307"><a href="#cb15-307"></a>result <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb15-308"><a href="#cb15-308"></a>  result_adsl,</span>
+<span id="cb15-309"><a href="#cb15-309"></a>  result_adae[<span class="fu">seq_len</span>(<span class="fu">nrow</span>(result_adae)), ]</span>
+<span id="cb15-310"><a href="#cb15-310"></a>)</span>
+<span id="cb15-311"><a href="#cb15-311"></a></span>
+<span id="cb15-312"><a href="#cb15-312"></a>result</span>
+<span id="cb15-313"><a href="#cb15-313"></a><span class="in">```</span></span>
+<span id="cb15-314"><a href="#cb15-314"></a></span>
+<span id="cb15-315"><a href="#cb15-315"></a><span class="fu">## Table by SMQ</span></span>
+<span id="cb15-316"><a href="#cb15-316"></a></span>
+<span id="cb15-319"><a href="#cb15-319"></a><span class="in">```{r}</span></span>
+<span id="cb15-320"><a href="#cb15-320"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-321"><a href="#cb15-321"></a></span>
+<span id="cb15-322"><a href="#cb15-322"></a><span class="co"># In progress</span></span>
+<span id="cb15-323"><a href="#cb15-323"></a><span class="in">```</span></span>
+<span id="cb15-324"><a href="#cb15-324"></a></span>
+<span id="cb15-325"><a href="#cb15-325"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb15-326"><a href="#cb15-326"></a></span>
+<span id="cb15-327"><a href="#cb15-327"></a><span class="fu">## `teal` App</span></span>
+<span id="cb15-328"><a href="#cb15-328"></a></span>
+<span id="cb15-329"><a href="#cb15-329"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb15-330"><a href="#cb15-330"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb15-331"><a href="#cb15-331"></a></span>
+<span id="cb15-332"><a href="#cb15-332"></a><span class="co"># In progress</span></span>
+<span id="cb15-333"><a href="#cb15-333"></a><span class="in">```</span></span>
+<span id="cb15-334"><a href="#cb15-334"></a></span>
+<span id="cb15-335"><a href="#cb15-335"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb15-336"><a href="#cb15-336"></a>:::</span>
+</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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+
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new file mode 100644
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@@ -0,0 +1,2821 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
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+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
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+  vertical-align: middle;
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+/* CSS for syntax highlighting */
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+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
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+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
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+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
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+ <span class="menu-text">AET01</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
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+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
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+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
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+ <span class="menu-text">AET09</span></a>
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+ <span class="menu-text">Concomitant Medications</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
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+ <span class="menu-text">DISCLOSUREST01</span></a>
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+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
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+  <div class="sidebar-item-container"> 
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+  </div>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
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+            <i class="bi bi-chevron-right ms-2"></i>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
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+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="true">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">ENTXX</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Enrollment Variants</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">ENT01 – Enrollment by Region, <br> Country, and Investigator Number</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">ENT01A – Enrollment by Country <br> and Investigator Number</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">ENT02 – Enrollment by Region, Country, <br> and Investigator Number/Name</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">ENT02A – Enrollment by Country <br> and Investigator Number/Name</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-6-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-6" role="tab" aria-controls="tabset-1-6" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-7-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-7" role="tab" aria-controls="tabset-1-7" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="enrollment01_cache/html/setup_09e185d3521be8bd3a62b117c6fb625e">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-13"><a href="#cb1-13"></a>    <span class="at">REGION1 =</span> <span class="fu">droplevels</span>(REGION1),</span>
+<span id="cb1-14"><a href="#cb1-14"></a>    <span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY),</span>
+<span id="cb1-15"><a href="#cb1-15"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">paste</span>(INVID, INVNAM, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb1-16"><a href="#cb1-16"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">INVID =</span> <span class="fu">factor</span>(INVID),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">SITEID =</span> <span class="fu">factor</span>(SITEID),</span>
+<span id="cb1-20"><a href="#cb1-20"></a>    <span class="at">INVNAM =</span> <span class="fu">factor</span>(INVNAM),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">factor</span>(INVID_INVNAM)</span>
+<span id="cb1-22"><a href="#cb1-22"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-24"><a href="#cb1-24"></a>    <span class="at">INVID_INVNAM =</span> <span class="st">"Investigator Number/Name"</span>,</span>
+<span id="cb1-25"><a href="#cb1-25"></a>    <span class="at">REGION1 =</span> <span class="st">"Geographic Region 1"</span>,</span>
+<span id="cb1-26"><a href="#cb1-26"></a>    <span class="at">COUNTRY =</span> <span class="st">"Country"</span>,</span>
+<span id="cb1-27"><a href="#cb1-27"></a>    <span class="at">INVID =</span> <span class="st">"Investigator Identifier"</span></span>
+<span id="cb1-28"><a href="#cb1-28"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY, INVID)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="enrollment01_cache/html/variant1_69162144eb6a30dbb79b3ff609ff0c12">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a><span class="co"># Define the split function</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-3"><a href="#cb2-3"></a></span>
+<span id="cb2-4"><a href="#cb2-4"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-6"><a href="#cb2-6"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-7"><a href="#cb2-7"></a>  <span class="fu">split_rows_by</span>(<span class="st">"REGION1"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>REGION1)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb2-11"><a href="#cb2-11"></a>  <span class="fu">analyze</span>(<span class="st">"INVID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-12"><a href="#cb2-12"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID"</span>, 2L)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb2-16"><a href="#cb2-16"></a></span>
+<span id="cb2-17"><a href="#cb2-17"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Geographic Region 1                                                                  
+  Country                     A: Drug X    B: Placebo   C: Combination   All Patients
+    Investigator Identifier    (N=134)      (N=134)        (N=132)         (N=400)   
+—————————————————————————————————————————————————————————————————————————————————————
+Africa                         8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+  NGA                          8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+    INV ID NGA-1                  3            3              4               10     
+    INV ID NGA-11                 1            2              3               6      
+    INV ID NGA-12                 0            1              1               2      
+    INV ID NGA-17                 2            0              0               2      
+    INV ID NGA-2                  1            1              0               2      
+    INV ID NGA-4                  1            0              1               2      
+    INV ID NGA-5                  0            0              1               1      
+    INV ID NGA-6                  0            0              1               1      
+Asia                          91 (67.9%)   94 (70.1%)     83 (62.9%)     268 (67.0%) 
+  CHN                         74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) 
+    INV ID CHN-1                  21           20             16              57     
+    INV ID CHN-10                 0            1              0               1      
+    INV ID CHN-11                 12           20             16              48     
+    INV ID CHN-12                 4            3              1               8      
+    INV ID CHN-13                 2            6              0               8      
+    INV ID CHN-14                 4            2              3               9      
+    INV ID CHN-15                 2            0              4               6      
+    INV ID CHN-16                 0            3              3               6      
+    INV ID CHN-17                 4            4              3               11     
+    INV ID CHN-18                 1            0              2               3      
+    INV ID CHN-2                  9            4              3               16     
+    INV ID CHN-3                  5            1              5               11     
+    INV ID CHN-4                  3            3              3               9      
+    INV ID CHN-5                  4            3              4               11     
+    INV ID CHN-6                  1            3              0               4      
+    INV ID CHN-7                  0            5              1               6      
+    INV ID CHN-8                  1            1              0               2      
+    INV ID CHN-9                  1            2              0               3      
+  PAK                         12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  
+    INV ID PAK-1                  2            4              4               10     
+    INV ID PAK-11                 4            3              2               9      
+    INV ID PAK-12                 2            0              0               2      
+    INV ID PAK-13                 1            1              0               2      
+    INV ID PAK-14                 1            0              0               1      
+    INV ID PAK-15                 1            0              0               1      
+    INV ID PAK-2                  1            0              2               3      
+    INV ID PAK-4                  0            1              1               2      
+    INV ID PAK-5                  0            0              1               1      
+  JPN                          5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  
+    INV ID JPN-1                  2            2              1               5      
+    INV ID JPN-11                 0            0              3               3      
+    INV ID JPN-12                 0            0              1               1      
+    INV ID JPN-14                 0            1              0               1      
+    INV ID JPN-17                 0            0              2               2      
+    INV ID JPN-18                 1            0              0               1      
+    INV ID JPN-2                  0            0              1               1      
+    INV ID JPN-3                  0            1              0               1      
+    INV ID JPN-5                  1            0              1               2      
+    INV ID JPN-6                  1            0              0               1      
+Eurasia                        5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+  RUS                          5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+    INV ID RUS-1                  1            0              0               1      
+    INV ID RUS-11                 0            2              2               4      
+    INV ID RUS-12                 0            1              0               1      
+    INV ID RUS-13                 1            0              0               1      
+    INV ID RUS-14                 0            0              1               1      
+    INV ID RUS-16                 1            1              0               2      
+    INV ID RUS-18                 1            0              0               1      
+    INV ID RUS-2                  0            1              0               1      
+    INV ID RUS-3                  0            0              1               1      
+    INV ID RUS-4                  0            2              1               3      
+    INV ID RUS-5                  0            1              0               1      
+    INV ID RUS-6                  1            0              0               1      
+    INV ID RUS-7                  0            0              1               1      
+Europe                         4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+  GBR                          4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+    INV ID GBR-1                  2            0              1               3      
+    INV ID GBR-11                 0            1              1               2      
+    INV ID GBR-13                 1            0              0               1      
+    INV ID GBR-15                 1            0              0               1      
+    INV ID GBR-17                 0            1              0               1      
+    INV ID GBR-6                  0            1              0               1      
+North America                 13 (9.7%)    15 (11.2%)     20 (15.2%)      48 (12.0%) 
+  USA                         10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) 
+    INV ID USA-1                  1            4              5               10     
+    INV ID USA-11                 4            2              3               9      
+    INV ID USA-12                 1            2              3               6      
+    INV ID USA-14                 1            0              0               1      
+    INV ID USA-15                 0            1              1               2      
+    INV ID USA-17                 1            1              0               2      
+    INV ID USA-19                 0            0              1               1      
+    INV ID USA-2                  0            0              1               1      
+    INV ID USA-3                  1            0              1               2      
+    INV ID USA-4                  0            1              1               2      
+    INV ID USA-5                  0            1              0               1      
+    INV ID USA-6                  0            1              0               1      
+    INV ID USA-8                  0            0              1               1      
+    INV ID USA-9                  1            0              0               1      
+  CAN                          3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  
+    INV ID CAN-1                  1            1              0               2      
+    INV ID CAN-11                 1            0              1               2      
+    INV ID CAN-14                 1            0              0               1      
+    INV ID CAN-4                  0            1              1               2      
+    INV ID CAN-5                  0            0              1               1      
+South America                 13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+  BRA                         13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+    INV ID BRA-1                  4            2              2               8      
+    INV ID BRA-11                 4            0              4               8      
+    INV ID BRA-12                 0            1              0               1      
+    INV ID BRA-13                 1            0              0               1      
+    INV ID BRA-14                 1            0              1               2      
+    INV ID BRA-15                 1            0              0               1      
+    INV ID BRA-2                  1            1              0               2      
+    INV ID BRA-3                  0            2              0               2      
+    INV ID BRA-4                  0            1              1               2      
+    INV ID BRA-5                  0            0              1               1      
+    INV ID BRA-6                  1            0              0               1      
+    INV ID BRA-7                  0            0              1               1      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="enrollment01_cache/html/variant2_230093f1168e8d9dd85cc03e274224fd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-6"><a href="#cb4-6"></a>  <span class="fu">analyze</span>(<span class="st">"INVID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-7"><a href="#cb4-7"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID"</span>, 1L)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Country                     A: Drug X    B: Placebo   C: Combination   All Patients
+  Investigator Identifier    (N=134)      (N=134)        (N=132)         (N=400)   
+———————————————————————————————————————————————————————————————————————————————————
+CHN                         74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) 
+  INV ID CHN-1                  21           20             16              57     
+  INV ID CHN-10                 0            1              0               1      
+  INV ID CHN-11                 12           20             16              48     
+  INV ID CHN-12                 4            3              1               8      
+  INV ID CHN-13                 2            6              0               8      
+  INV ID CHN-14                 4            2              3               9      
+  INV ID CHN-15                 2            0              4               6      
+  INV ID CHN-16                 0            3              3               6      
+  INV ID CHN-17                 4            4              3               11     
+  INV ID CHN-18                 1            0              2               3      
+  INV ID CHN-2                  9            4              3               16     
+  INV ID CHN-3                  5            1              5               11     
+  INV ID CHN-4                  3            3              3               9      
+  INV ID CHN-5                  4            3              4               11     
+  INV ID CHN-6                  1            3              0               4      
+  INV ID CHN-7                  0            5              1               6      
+  INV ID CHN-8                  1            1              0               2      
+  INV ID CHN-9                  1            2              0               3      
+USA                         10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) 
+  INV ID USA-1                  1            4              5               10     
+  INV ID USA-11                 4            2              3               9      
+  INV ID USA-12                 1            2              3               6      
+  INV ID USA-14                 1            0              0               1      
+  INV ID USA-15                 0            1              1               2      
+  INV ID USA-17                 1            1              0               2      
+  INV ID USA-19                 0            0              1               1      
+  INV ID USA-2                  0            0              1               1      
+  INV ID USA-3                  1            0              1               2      
+  INV ID USA-4                  0            1              1               2      
+  INV ID USA-5                  0            1              0               1      
+  INV ID USA-6                  0            1              0               1      
+  INV ID USA-8                  0            0              1               1      
+  INV ID USA-9                  1            0              0               1      
+BRA                         13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+  INV ID BRA-1                  4            2              2               8      
+  INV ID BRA-11                 4            0              4               8      
+  INV ID BRA-12                 0            1              0               1      
+  INV ID BRA-13                 1            0              0               1      
+  INV ID BRA-14                 1            0              1               2      
+  INV ID BRA-15                 1            0              0               1      
+  INV ID BRA-2                  1            1              0               2      
+  INV ID BRA-3                  0            2              0               2      
+  INV ID BRA-4                  0            1              1               2      
+  INV ID BRA-5                  0            0              1               1      
+  INV ID BRA-6                  1            0              0               1      
+  INV ID BRA-7                  0            0              1               1      
+PAK                         12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  
+  INV ID PAK-1                  2            4              4               10     
+  INV ID PAK-11                 4            3              2               9      
+  INV ID PAK-12                 2            0              0               2      
+  INV ID PAK-13                 1            1              0               2      
+  INV ID PAK-14                 1            0              0               1      
+  INV ID PAK-15                 1            0              0               1      
+  INV ID PAK-2                  1            0              2               3      
+  INV ID PAK-4                  0            1              1               2      
+  INV ID PAK-5                  0            0              1               1      
+NGA                          8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+  INV ID NGA-1                  3            3              4               10     
+  INV ID NGA-11                 1            2              3               6      
+  INV ID NGA-12                 0            1              1               2      
+  INV ID NGA-17                 2            0              0               2      
+  INV ID NGA-2                  1            1              0               2      
+  INV ID NGA-4                  1            0              1               2      
+  INV ID NGA-5                  0            0              1               1      
+  INV ID NGA-6                  0            0              1               1      
+RUS                          5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+  INV ID RUS-1                  1            0              0               1      
+  INV ID RUS-11                 0            2              2               4      
+  INV ID RUS-12                 0            1              0               1      
+  INV ID RUS-13                 1            0              0               1      
+  INV ID RUS-14                 0            0              1               1      
+  INV ID RUS-16                 1            1              0               2      
+  INV ID RUS-18                 1            0              0               1      
+  INV ID RUS-2                  0            1              0               1      
+  INV ID RUS-3                  0            0              1               1      
+  INV ID RUS-4                  0            2              1               3      
+  INV ID RUS-5                  0            1              0               1      
+  INV ID RUS-6                  1            0              0               1      
+  INV ID RUS-7                  0            0              1               1      
+JPN                          5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  
+  INV ID JPN-1                  2            2              1               5      
+  INV ID JPN-11                 0            0              3               3      
+  INV ID JPN-12                 0            0              1               1      
+  INV ID JPN-14                 0            1              0               1      
+  INV ID JPN-17                 0            0              2               2      
+  INV ID JPN-18                 1            0              0               1      
+  INV ID JPN-2                  0            0              1               1      
+  INV ID JPN-3                  0            1              0               1      
+  INV ID JPN-5                  1            0              1               2      
+  INV ID JPN-6                  1            0              0               1      
+GBR                          4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+  INV ID GBR-1                  2            0              1               3      
+  INV ID GBR-11                 0            1              1               2      
+  INV ID GBR-13                 1            0              0               1      
+  INV ID GBR-15                 1            0              0               1      
+  INV ID GBR-17                 0            1              0               1      
+  INV ID GBR-6                  0            1              0               1      
+CAN                          3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  
+  INV ID CAN-1                  1            1              0               2      
+  INV ID CAN-11                 1            0              1               2      
+  INV ID CAN-14                 1            0              0               1      
+  INV ID CAN-4                  0            1              1               2      
+  INV ID CAN-5                  0            0              1               1      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-test="{&quot;result_v3&quot;:&quot;result&quot;}" data-hash="enrollment01_cache/html/variant3_b390216a29700fe6a388918a5cee5535">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-2"><a href="#cb6-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-3"><a href="#cb6-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-4"><a href="#cb6-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"REGION1"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>REGION1)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-5"><a href="#cb6-5"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-6"><a href="#cb6-6"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">analyze</span>(<span class="st">"INVID_INVNAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-9"><a href="#cb6-9"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID_INVNAM"</span>, 2L)</span>
+<span id="cb6-10"><a href="#cb6-10"></a></span>
+<span id="cb6-11"><a href="#cb6-11"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb6-12"><a href="#cb6-12"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb6-13"><a href="#cb6-13"></a></span>
+<span id="cb6-14"><a href="#cb6-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Geographic Region 1                                                                         
+  Country                            A: Drug X    B: Placebo   C: Combination   All Patients
+    Investigator Number/Name          (N=134)      (N=134)        (N=132)         (N=400)   
+————————————————————————————————————————————————————————————————————————————————————————————
+Africa                                8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+  NGA                                 8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+    INV ID NGA-1 / Dr. NGA-1 Doe         3            3              4               10     
+    INV ID NGA-11 / Dr. NGA-11 Doe       1            2              3               6      
+    INV ID NGA-12 / Dr. NGA-12 Doe       0            1              1               2      
+    INV ID NGA-17 / Dr. NGA-17 Doe       2            0              0               2      
+    INV ID NGA-2 / Dr. NGA-2 Doe         1            1              0               2      
+    INV ID NGA-4 / Dr. NGA-4 Doe         1            0              1               2      
+    INV ID NGA-5 / Dr. NGA-5 Doe         0            0              1               1      
+    INV ID NGA-6 / Dr. NGA-6 Doe         0            0              1               1      
+Asia                                 91 (67.9%)   94 (70.1%)     83 (62.9%)     268 (67.0%) 
+  CHN                                74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) 
+    INV ID CHN-1 / Dr. CHN-1 Doe         21           20             16              57     
+    INV ID CHN-10 / Dr. CHN-10 Doe       0            1              0               1      
+    INV ID CHN-11 / Dr. CHN-11 Doe       12           20             16              48     
+    INV ID CHN-12 / Dr. CHN-12 Doe       4            3              1               8      
+    INV ID CHN-13 / Dr. CHN-13 Doe       2            6              0               8      
+    INV ID CHN-14 / Dr. CHN-14 Doe       4            2              3               9      
+    INV ID CHN-15 / Dr. CHN-15 Doe       2            0              4               6      
+    INV ID CHN-16 / Dr. CHN-16 Doe       0            3              3               6      
+    INV ID CHN-17 / Dr. CHN-17 Doe       4            4              3               11     
+    INV ID CHN-18 / Dr. CHN-18 Doe       1            0              2               3      
+    INV ID CHN-2 / Dr. CHN-2 Doe         9            4              3               16     
+    INV ID CHN-3 / Dr. CHN-3 Doe         5            1              5               11     
+    INV ID CHN-4 / Dr. CHN-4 Doe         3            3              3               9      
+    INV ID CHN-5 / Dr. CHN-5 Doe         4            3              4               11     
+    INV ID CHN-6 / Dr. CHN-6 Doe         1            3              0               4      
+    INV ID CHN-7 / Dr. CHN-7 Doe         0            5              1               6      
+    INV ID CHN-8 / Dr. CHN-8 Doe         1            1              0               2      
+    INV ID CHN-9 / Dr. CHN-9 Doe         1            2              0               3      
+  PAK                                12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  
+    INV ID PAK-1 / Dr. PAK-1 Doe         2            4              4               10     
+    INV ID PAK-11 / Dr. PAK-11 Doe       4            3              2               9      
+    INV ID PAK-12 / Dr. PAK-12 Doe       2            0              0               2      
+    INV ID PAK-13 / Dr. PAK-13 Doe       1            1              0               2      
+    INV ID PAK-14 / Dr. PAK-14 Doe       1            0              0               1      
+    INV ID PAK-15 / Dr. PAK-15 Doe       1            0              0               1      
+    INV ID PAK-2 / Dr. PAK-2 Doe         1            0              2               3      
+    INV ID PAK-4 / Dr. PAK-4 Doe         0            1              1               2      
+    INV ID PAK-5 / Dr. PAK-5 Doe         0            0              1               1      
+  JPN                                 5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  
+    INV ID JPN-1 / Dr. JPN-1 Doe         2            2              1               5      
+    INV ID JPN-11 / Dr. JPN-11 Doe       0            0              3               3      
+    INV ID JPN-12 / Dr. JPN-12 Doe       0            0              1               1      
+    INV ID JPN-14 / Dr. JPN-14 Doe       0            1              0               1      
+    INV ID JPN-17 / Dr. JPN-17 Doe       0            0              2               2      
+    INV ID JPN-18 / Dr. JPN-18 Doe       1            0              0               1      
+    INV ID JPN-2 / Dr. JPN-2 Doe         0            0              1               1      
+    INV ID JPN-3 / Dr. JPN-3 Doe         0            1              0               1      
+    INV ID JPN-5 / Dr. JPN-5 Doe         1            0              1               2      
+    INV ID JPN-6 / Dr. JPN-6 Doe         1            0              0               1      
+Eurasia                               5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+  RUS                                 5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+    INV ID RUS-1 / Dr. RUS-1 Doe         1            0              0               1      
+    INV ID RUS-11 / Dr. RUS-11 Doe       0            2              2               4      
+    INV ID RUS-12 / Dr. RUS-12 Doe       0            1              0               1      
+    INV ID RUS-13 / Dr. RUS-13 Doe       1            0              0               1      
+    INV ID RUS-14 / Dr. RUS-14 Doe       0            0              1               1      
+    INV ID RUS-16 / Dr. RUS-16 Doe       1            1              0               2      
+    INV ID RUS-18 / Dr. RUS-18 Doe       1            0              0               1      
+    INV ID RUS-2 / Dr. RUS-2 Doe         0            1              0               1      
+    INV ID RUS-3 / Dr. RUS-3 Doe         0            0              1               1      
+    INV ID RUS-4 / Dr. RUS-4 Doe         0            2              1               3      
+    INV ID RUS-5 / Dr. RUS-5 Doe         0            1              0               1      
+    INV ID RUS-6 / Dr. RUS-6 Doe         1            0              0               1      
+    INV ID RUS-7 / Dr. RUS-7 Doe         0            0              1               1      
+Europe                                4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+  GBR                                 4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+    INV ID GBR-1 / Dr. GBR-1 Doe         2            0              1               3      
+    INV ID GBR-11 / Dr. GBR-11 Doe       0            1              1               2      
+    INV ID GBR-13 / Dr. GBR-13 Doe       1            0              0               1      
+    INV ID GBR-15 / Dr. GBR-15 Doe       1            0              0               1      
+    INV ID GBR-17 / Dr. GBR-17 Doe       0            1              0               1      
+    INV ID GBR-6 / Dr. GBR-6 Doe         0            1              0               1      
+North America                        13 (9.7%)    15 (11.2%)     20 (15.2%)      48 (12.0%) 
+  USA                                10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) 
+    INV ID USA-1 / Dr. USA-1 Doe         1            4              5               10     
+    INV ID USA-11 / Dr. USA-11 Doe       4            2              3               9      
+    INV ID USA-12 / Dr. USA-12 Doe       1            2              3               6      
+    INV ID USA-14 / Dr. USA-14 Doe       1            0              0               1      
+    INV ID USA-15 / Dr. USA-15 Doe       0            1              1               2      
+    INV ID USA-17 / Dr. USA-17 Doe       1            1              0               2      
+    INV ID USA-19 / Dr. USA-19 Doe       0            0              1               1      
+    INV ID USA-2 / Dr. USA-2 Doe         0            0              1               1      
+    INV ID USA-3 / Dr. USA-3 Doe         1            0              1               2      
+    INV ID USA-4 / Dr. USA-4 Doe         0            1              1               2      
+    INV ID USA-5 / Dr. USA-5 Doe         0            1              0               1      
+    INV ID USA-6 / Dr. USA-6 Doe         0            1              0               1      
+    INV ID USA-8 / Dr. USA-8 Doe         0            0              1               1      
+    INV ID USA-9 / Dr. USA-9 Doe         1            0              0               1      
+  CAN                                 3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  
+    INV ID CAN-1 / Dr. CAN-1 Doe         1            1              0               2      
+    INV ID CAN-11 / Dr. CAN-11 Doe       1            0              1               2      
+    INV ID CAN-14 / Dr. CAN-14 Doe       1            0              0               1      
+    INV ID CAN-4 / Dr. CAN-4 Doe         0            1              1               2      
+    INV ID CAN-5 / Dr. CAN-5 Doe         0            0              1               1      
+South America                        13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+  BRA                                13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+    INV ID BRA-1 / Dr. BRA-1 Doe         4            2              2               8      
+    INV ID BRA-11 / Dr. BRA-11 Doe       4            0              4               8      
+    INV ID BRA-12 / Dr. BRA-12 Doe       0            1              0               1      
+    INV ID BRA-13 / Dr. BRA-13 Doe       1            0              0               1      
+    INV ID BRA-14 / Dr. BRA-14 Doe       1            0              1               2      
+    INV ID BRA-15 / Dr. BRA-15 Doe       1            0              0               1      
+    INV ID BRA-2 / Dr. BRA-2 Doe         1            1              0               2      
+    INV ID BRA-3 / Dr. BRA-3 Doe         0            2              0               2      
+    INV ID BRA-4 / Dr. BRA-4 Doe         0            1              1               2      
+    INV ID BRA-5 / Dr. BRA-5 Doe         0            0              1               1      
+    INV ID BRA-6 / Dr. BRA-6 Doe         1            0              0               1      
+    INV ID BRA-7 / Dr. BRA-7 Doe         0            0              1               1      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<div class="cell" data-test="{&quot;result_v4&quot;:&quot;result&quot;}" data-hash="enrollment01_cache/html/variant4_2f42da5a8ac2868dbdbc35c66350addc">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-2"><a href="#cb8-2"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-3"><a href="#cb8-3"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-4"><a href="#cb8-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb8-5"><a href="#cb8-5"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb8-6"><a href="#cb8-6"></a>  <span class="fu">analyze</span>(<span class="st">"INVID_INVNAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb8-7"><a href="#cb8-7"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID_INVNAM"</span>, 1L)</span>
+<span id="cb8-8"><a href="#cb8-8"></a></span>
+<span id="cb8-9"><a href="#cb8-9"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb8-10"><a href="#cb8-10"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb8-11"><a href="#cb8-11"></a></span>
+<span id="cb8-12"><a href="#cb8-12"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Country                            A: Drug X    B: Placebo   C: Combination   All Patients
+  Investigator Number/Name          (N=134)      (N=134)        (N=132)         (N=400)   
+——————————————————————————————————————————————————————————————————————————————————————————
+CHN                                74 (55.2%)   81 (60.4%)     64 (48.5%)     219 (54.8%) 
+  INV ID CHN-1 / Dr. CHN-1 Doe         21           20             16              57     
+  INV ID CHN-10 / Dr. CHN-10 Doe       0            1              0               1      
+  INV ID CHN-11 / Dr. CHN-11 Doe       12           20             16              48     
+  INV ID CHN-12 / Dr. CHN-12 Doe       4            3              1               8      
+  INV ID CHN-13 / Dr. CHN-13 Doe       2            6              0               8      
+  INV ID CHN-14 / Dr. CHN-14 Doe       4            2              3               9      
+  INV ID CHN-15 / Dr. CHN-15 Doe       2            0              4               6      
+  INV ID CHN-16 / Dr. CHN-16 Doe       0            3              3               6      
+  INV ID CHN-17 / Dr. CHN-17 Doe       4            4              3               11     
+  INV ID CHN-18 / Dr. CHN-18 Doe       1            0              2               3      
+  INV ID CHN-2 / Dr. CHN-2 Doe         9            4              3               16     
+  INV ID CHN-3 / Dr. CHN-3 Doe         5            1              5               11     
+  INV ID CHN-4 / Dr. CHN-4 Doe         3            3              3               9      
+  INV ID CHN-5 / Dr. CHN-5 Doe         4            3              4               11     
+  INV ID CHN-6 / Dr. CHN-6 Doe         1            3              0               4      
+  INV ID CHN-7 / Dr. CHN-7 Doe         0            5              1               6      
+  INV ID CHN-8 / Dr. CHN-8 Doe         1            1              0               2      
+  INV ID CHN-9 / Dr. CHN-9 Doe         1            2              0               3      
+USA                                10 (7.5%)    13 (9.7%)      17 (12.9%)      40 (10.0%) 
+  INV ID USA-1 / Dr. USA-1 Doe         1            4              5               10     
+  INV ID USA-11 / Dr. USA-11 Doe       4            2              3               9      
+  INV ID USA-12 / Dr. USA-12 Doe       1            2              3               6      
+  INV ID USA-14 / Dr. USA-14 Doe       1            0              0               1      
+  INV ID USA-15 / Dr. USA-15 Doe       0            1              1               2      
+  INV ID USA-17 / Dr. USA-17 Doe       1            1              0               2      
+  INV ID USA-19 / Dr. USA-19 Doe       0            0              1               1      
+  INV ID USA-2 / Dr. USA-2 Doe         0            0              1               1      
+  INV ID USA-3 / Dr. USA-3 Doe         1            0              1               2      
+  INV ID USA-4 / Dr. USA-4 Doe         0            1              1               2      
+  INV ID USA-5 / Dr. USA-5 Doe         0            1              0               1      
+  INV ID USA-6 / Dr. USA-6 Doe         0            1              0               1      
+  INV ID USA-8 / Dr. USA-8 Doe         0            0              1               1      
+  INV ID USA-9 / Dr. USA-9 Doe         1            0              0               1      
+BRA                                13 (9.7%)     7 (5.2%)      10 (7.6%)       30 (7.5%)  
+  INV ID BRA-1 / Dr. BRA-1 Doe         4            2              2               8      
+  INV ID BRA-11 / Dr. BRA-11 Doe       4            0              4               8      
+  INV ID BRA-12 / Dr. BRA-12 Doe       0            1              0               1      
+  INV ID BRA-13 / Dr. BRA-13 Doe       1            0              0               1      
+  INV ID BRA-14 / Dr. BRA-14 Doe       1            0              1               2      
+  INV ID BRA-15 / Dr. BRA-15 Doe       1            0              0               1      
+  INV ID BRA-2 / Dr. BRA-2 Doe         1            1              0               2      
+  INV ID BRA-3 / Dr. BRA-3 Doe         0            2              0               2      
+  INV ID BRA-4 / Dr. BRA-4 Doe         0            1              1               2      
+  INV ID BRA-5 / Dr. BRA-5 Doe         0            0              1               1      
+  INV ID BRA-6 / Dr. BRA-6 Doe         1            0              0               1      
+  INV ID BRA-7 / Dr. BRA-7 Doe         0            0              1               1      
+PAK                                12 (9.0%)     9 (6.7%)      10 (7.6%)       31 (7.8%)  
+  INV ID PAK-1 / Dr. PAK-1 Doe         2            4              4               10     
+  INV ID PAK-11 / Dr. PAK-11 Doe       4            3              2               9      
+  INV ID PAK-12 / Dr. PAK-12 Doe       2            0              0               2      
+  INV ID PAK-13 / Dr. PAK-13 Doe       1            1              0               2      
+  INV ID PAK-14 / Dr. PAK-14 Doe       1            0              0               1      
+  INV ID PAK-15 / Dr. PAK-15 Doe       1            0              0               1      
+  INV ID PAK-2 / Dr. PAK-2 Doe         1            0              2               3      
+  INV ID PAK-4 / Dr. PAK-4 Doe         0            1              1               2      
+  INV ID PAK-5 / Dr. PAK-5 Doe         0            0              1               1      
+NGA                                 8 (6.0%)     7 (5.2%)      11 (8.3%)       26 (6.5%)  
+  INV ID NGA-1 / Dr. NGA-1 Doe         3            3              4               10     
+  INV ID NGA-11 / Dr. NGA-11 Doe       1            2              3               6      
+  INV ID NGA-12 / Dr. NGA-12 Doe       0            1              1               2      
+  INV ID NGA-17 / Dr. NGA-17 Doe       2            0              0               2      
+  INV ID NGA-2 / Dr. NGA-2 Doe         1            1              0               2      
+  INV ID NGA-4 / Dr. NGA-4 Doe         1            0              1               2      
+  INV ID NGA-5 / Dr. NGA-5 Doe         0            0              1               1      
+  INV ID NGA-6 / Dr. NGA-6 Doe         0            0              1               1      
+RUS                                 5 (3.7%)     8 (6.0%)       6 (4.5%)       19 (4.8%)  
+  INV ID RUS-1 / Dr. RUS-1 Doe         1            0              0               1      
+  INV ID RUS-11 / Dr. RUS-11 Doe       0            2              2               4      
+  INV ID RUS-12 / Dr. RUS-12 Doe       0            1              0               1      
+  INV ID RUS-13 / Dr. RUS-13 Doe       1            0              0               1      
+  INV ID RUS-14 / Dr. RUS-14 Doe       0            0              1               1      
+  INV ID RUS-16 / Dr. RUS-16 Doe       1            1              0               2      
+  INV ID RUS-18 / Dr. RUS-18 Doe       1            0              0               1      
+  INV ID RUS-2 / Dr. RUS-2 Doe         0            1              0               1      
+  INV ID RUS-3 / Dr. RUS-3 Doe         0            0              1               1      
+  INV ID RUS-4 / Dr. RUS-4 Doe         0            2              1               3      
+  INV ID RUS-5 / Dr. RUS-5 Doe         0            1              0               1      
+  INV ID RUS-6 / Dr. RUS-6 Doe         1            0              0               1      
+  INV ID RUS-7 / Dr. RUS-7 Doe         0            0              1               1      
+JPN                                 5 (3.7%)     4 (3.0%)       9 (6.8%)       18 (4.5%)  
+  INV ID JPN-1 / Dr. JPN-1 Doe         2            2              1               5      
+  INV ID JPN-11 / Dr. JPN-11 Doe       0            0              3               3      
+  INV ID JPN-12 / Dr. JPN-12 Doe       0            0              1               1      
+  INV ID JPN-14 / Dr. JPN-14 Doe       0            1              0               1      
+  INV ID JPN-17 / Dr. JPN-17 Doe       0            0              2               2      
+  INV ID JPN-18 / Dr. JPN-18 Doe       1            0              0               1      
+  INV ID JPN-2 / Dr. JPN-2 Doe         0            0              1               1      
+  INV ID JPN-3 / Dr. JPN-3 Doe         0            1              0               1      
+  INV ID JPN-5 / Dr. JPN-5 Doe         1            0              1               2      
+  INV ID JPN-6 / Dr. JPN-6 Doe         1            0              0               1      
+GBR                                 4 (3.0%)     3 (2.2%)       2 (1.5%)        9 (2.2%)  
+  INV ID GBR-1 / Dr. GBR-1 Doe         2            0              1               3      
+  INV ID GBR-11 / Dr. GBR-11 Doe       0            1              1               2      
+  INV ID GBR-13 / Dr. GBR-13 Doe       1            0              0               1      
+  INV ID GBR-15 / Dr. GBR-15 Doe       1            0              0               1      
+  INV ID GBR-17 / Dr. GBR-17 Doe       0            1              0               1      
+  INV ID GBR-6 / Dr. GBR-6 Doe         0            1              0               1      
+CAN                                 3 (2.2%)     2 (1.5%)       3 (2.3%)        8 (2.0%)  
+  INV ID CAN-1 / Dr. CAN-1 Doe         1            1              0               2      
+  INV ID CAN-11 / Dr. CAN-11 Doe       1            0              1               2      
+  INV ID CAN-14 / Dr. CAN-14 Doe       1            0              0               1      
+  INV ID CAN-4 / Dr. CAN-4 Doe         0            1              1               2      
+  INV ID CAN-5 / Dr. CAN-5 Doe         0            0              1               1      </code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-6" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-6-tab">
+<p>Note that for this module application, only the variables passed into <code>by_vars</code> are used when <code>row_groups</code> is selected. Variables passed into <code>analyze_vars</code> are additionally used when <code>row_groups</code> is deselected.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:8}" data-hash="enrollment01_cache/html/teal_b24c8ae2fd36e90a480612827d7b7768">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb10"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb10-1"><a href="#cb10-1"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-9"><a href="#cb10-9"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-10"><a href="#cb10-10"></a></span>
+<span id="cb10-11"><a href="#cb10-11"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-15"><a href="#cb10-15"></a>    <span class="at">REGION1 =</span> <span class="fu">droplevels</span>(REGION1),</span>
+<span id="cb10-16"><a href="#cb10-16"></a>    <span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY),</span>
+<span id="cb10-17"><a href="#cb10-17"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">paste</span>(INVID, INVNAM, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb10-18"><a href="#cb10-18"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-19"><a href="#cb10-19"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY, INVID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-20"><a href="#cb10-20"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-21"><a href="#cb10-21"></a>    <span class="at">INVID =</span> <span class="fu">factor</span>(INVID),</span>
+<span id="cb10-22"><a href="#cb10-22"></a>    <span class="at">SITEID =</span> <span class="fu">factor</span>(SITEID),</span>
+<span id="cb10-23"><a href="#cb10-23"></a>    <span class="at">INVNAM =</span> <span class="fu">factor</span>(INVNAM),</span>
+<span id="cb10-24"><a href="#cb10-24"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">factor</span>(INVID_INVNAM)</span>
+<span id="cb10-25"><a href="#cb10-25"></a>  )</span>
+<span id="cb10-26"><a href="#cb10-26"></a></span>
+<span id="cb10-27"><a href="#cb10-27"></a><span class="fu">var_labels</span>(adsl) <span class="ot">&lt;-</span> <span class="fu">c</span>(adsl_labels, <span class="st">"Investigator Number/Name"</span>)</span>
+<span id="cb10-28"><a href="#cb10-28"></a></span>
+<span id="cb10-29"><a href="#cb10-29"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-30"><a href="#cb10-30"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-31"><a href="#cb10-31"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb10-32"><a href="#cb10-32"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb10-33"><a href="#cb10-33"></a><span class="st">                  ADSL_labels &lt;- var_labels(ADSL)</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a><span class="st">                  ADSL &lt;- ADSL %&gt;% mutate(</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a><span class="st">                    REGION1 = droplevels(REGION1),</span></span>
+<span id="cb10-36"><a href="#cb10-36"></a><span class="st">                    COUNTRY = droplevels(COUNTRY),</span></span>
+<span id="cb10-37"><a href="#cb10-37"></a><span class="st">                    INVID_INVNAM = paste(INVID, INVNAM, sep = " / ")</span></span>
+<span id="cb10-38"><a href="#cb10-38"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb10-39"><a href="#cb10-39"></a><span class="st">                    arrange(REGION1, COUNTRY, INVID) %&gt;%</span></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="st">                    mutate(</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a><span class="st">                      INVID = factor(INVID),</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a><span class="st">                      SITEID = factor(SITEID),</span></span>
+<span id="cb10-43"><a href="#cb10-43"></a><span class="st">                      INVNAM = factor(INVNAM),</span></span>
+<span id="cb10-44"><a href="#cb10-44"></a><span class="st">                      INVID_INVNAM = factor(INVID_INVNAM)</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a><span class="st">                    )</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a></span>
+<span id="cb10-47"><a href="#cb10-47"></a><span class="st">                  var_labels(ADSL) &lt;- c(ADSL_labels, "Investigator Number/Name")'</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>    ),</span>
+<span id="cb10-49"><a href="#cb10-49"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-50"><a href="#cb10-50"></a>  ),</span>
+<span id="cb10-51"><a href="#cb10-51"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-52"><a href="#cb10-52"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-53"><a href="#cb10-53"></a>      <span class="at">label =</span> <span class="st">"Enrollment Table"</span>,</span>
+<span id="cb10-54"><a href="#cb10-54"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb10-55"><a href="#cb10-55"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-56"><a href="#cb10-56"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-57"><a href="#cb10-57"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-58"><a href="#cb10-58"></a>      ),</span>
+<span id="cb10-59"><a href="#cb10-59"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-60"><a href="#cb10-60"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"REGION1"</span>, <span class="st">"COUNTRY"</span>, <span class="st">"SITEID"</span>, <span class="st">"INVID"</span>, <span class="st">"INVNAM"</span>, <span class="st">"INVID_INVNAM"</span>)),</span>
+<span id="cb10-61"><a href="#cb10-61"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"REGION1"</span>)</span>
+<span id="cb10-62"><a href="#cb10-62"></a>      ),</span>
+<span id="cb10-63"><a href="#cb10-63"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-64"><a href="#cb10-64"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"REGION1"</span>, <span class="st">"COUNTRY"</span>, <span class="st">"SITEID"</span>, <span class="st">"INVID"</span>, <span class="st">"INVNAM"</span>, <span class="st">"INVID_INVNAM"</span>)),</span>
+<span id="cb10-65"><a href="#cb10-65"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"SITEID"</span>)</span>
+<span id="cb10-66"><a href="#cb10-66"></a>      ),</span>
+<span id="cb10-67"><a href="#cb10-67"></a>      <span class="at">denominator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-68"><a href="#cb10-68"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"N"</span>, <span class="st">"omit"</span>),</span>
+<span id="cb10-69"><a href="#cb10-69"></a>        <span class="at">selected =</span> <span class="st">"N"</span>,</span>
+<span id="cb10-70"><a href="#cb10-70"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-71"><a href="#cb10-71"></a>      ),</span>
+<span id="cb10-72"><a href="#cb10-72"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-73"><a href="#cb10-73"></a>      <span class="at">row_groups =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-74"><a href="#cb10-74"></a>    )</span>
+<span id="cb10-75"><a href="#cb10-75"></a>  )</span>
+<span id="cb10-76"><a href="#cb10-76"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:37:53.7358 pid:14074 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb12"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb12-1"><a href="#cb12-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="enrollment01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-7" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-7-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="enrollment01_cache/html/sessioninfo_f7528b3830f42fc02b5469d76f3d9f8a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb13"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb13-1"><a href="#cb13-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] scda_0.1.6                   forcats_1.0.0               
+[13] dplyr_1.1.3                 
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       purrr_1.0.2           shinyWidgets_0.8.0   
+[25] geepack_1.3.9         grid_4.3.1            fansi_1.0.4          
+[28] teal.logger_0.1.3     xtable_1.8-4          colorspace_2.1-0     
+[31] ggplot2_3.4.3         emmeans_1.8.8         scales_1.2.1         
+[34] MASS_7.3-60           cli_3.6.1             mvtnorm_1.2-3        
+[37] rmarkdown_2.25        generics_0.1.3        rstudioapi_0.15.0    
+[40] cachem_1.0.8          splines_4.3.1         assertthat_0.2.1     
+[43] vctrs_0.6.3           webshot_0.5.5         Matrix_1.6-1.1       
+[46] sandwich_3.0-2        jsonlite_1.8.7        callr_3.7.3          
+[49] teal.widgets_0.4.0    testthat_3.1.10       fontawesome_0.5.2    
+[52] jquerylib_0.1.4       tidyr_1.3.0           glue_1.6.2           
+[55] ps_1.7.5              codetools_0.2-19      gtable_0.3.4         
+[58] later_1.3.1           shinycssloaders_1.0.0 munsell_0.5.0        
+[61] tibble_3.2.1          logger_0.2.2          pillar_1.9.0         
+[64] htmltools_0.5.6       brio_1.1.3            R6_2.5.1             
+[67] Rdpack_2.5            evaluate_0.21         lattice_0.21-8       
+[70] rbibutils_2.2.15      backports_1.4.1       memoise_2.0.1        
+[73] broom_1.0.5           teal.reporter_0.2.1   httpuv_1.6.11        
+[76] bslib_0.5.1           Rcpp_1.0.11           coda_0.19-4          
+[79] nlme_3.1-163          checkmate_2.2.0       xfun_0.40            
+[82] zoo_1.8-12            pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="enrollment01_cache/html/snapshot_16a60af1b17dbfe3b560a0d070890f61">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb15"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb15-1"><a href="#cb15-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-2"><a href="#cb15-2"></a></span>
+<span id="cb15-3"><a href="#cb15-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb15-4"><a href="#cb15-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb15-5"><a href="#cb15-5"></a></span>
+<span id="cb15-6"><a href="#cb15-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb15-7"><a href="#cb15-7"></a></span>
+<span id="cb15-8"><a href="#cb15-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb15-9"><a href="#cb15-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb15-10"><a href="#cb15-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb15-11"><a href="#cb15-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/safety/enrollment01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
+    }
+  }
+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
+      toggleBodyColorMode(bsSheetEl);
+    }
+  }
+  toggleBodyColorPrimary();  
+  const disableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'prefetch';
+    }
+  }
+  const enableStylesheet = (stylesheets) => {
+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
+    }
+  }
+  const manageTransitions = (selector, allowTransitions) => {
+    const els = window.document.querySelectorAll(selector);
+    for (let i=0; i < els.length; i++) {
+      const el = els[i];
+      if (allowTransitions) {
+        el.classList.remove('notransition');
+      } else {
+        el.classList.add('notransition');
+      }
+    }
+  }
+  const toggleColorMode = (alternate) => {
+    // Switch the stylesheets
+    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
+    manageTransitions('#quarto-margin-sidebar .nav-link', false);
+    if (alternate) {
+      enableStylesheet(alternateStylesheets);
+      for (const sheetNode of alternateStylesheets) {
+        if (sheetNode.id === "quarto-bootstrap") {
+          toggleBodyColorMode(sheetNode);
+        }
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+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb16" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb16-1"><a href="#cb16-1"></a><span class="co">---</span></span>
+<span id="cb16-2"><a href="#cb16-2"></a><span class="an">title:</span><span class="co"> ENTXX</span></span>
+<span id="cb16-3"><a href="#cb16-3"></a><span class="an">subtitle:</span><span class="co"> Enrollment Variants</span></span>
+<span id="cb16-4"><a href="#cb16-4"></a><span class="co">---</span></span>
+<span id="cb16-5"><a href="#cb16-5"></a></span>
+<span id="cb16-6"><a href="#cb16-6"></a>------------------------------------------------------------------------</span>
+<span id="cb16-7"><a href="#cb16-7"></a></span>
+<span id="cb16-8"><a href="#cb16-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb16-9"><a href="#cb16-9"></a></span>
+<span id="cb16-10"><a href="#cb16-10"></a>::: panel-tabset</span>
+<span id="cb16-11"><a href="#cb16-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb16-12"><a href="#cb16-12"></a></span>
+<span id="cb16-13"><a href="#cb16-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb16-14"><a href="#cb16-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb16-15"><a href="#cb16-15"></a></span>
+<span id="cb16-16"><a href="#cb16-16"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-17"><a href="#cb16-17"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb16-18"><a href="#cb16-18"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-19"><a href="#cb16-19"></a><span class="fu">library</span>(tern)</span>
+<span id="cb16-20"><a href="#cb16-20"></a></span>
+<span id="cb16-21"><a href="#cb16-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-22"><a href="#cb16-22"></a></span>
+<span id="cb16-23"><a href="#cb16-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-24"><a href="#cb16-24"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-25"><a href="#cb16-25"></a></span>
+<span id="cb16-26"><a href="#cb16-26"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-27"><a href="#cb16-27"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-28"><a href="#cb16-28"></a>    <span class="at">REGION1 =</span> <span class="fu">droplevels</span>(REGION1),</span>
+<span id="cb16-29"><a href="#cb16-29"></a>    <span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY),</span>
+<span id="cb16-30"><a href="#cb16-30"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">paste</span>(INVID, INVNAM, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb16-31"><a href="#cb16-31"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-32"><a href="#cb16-32"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-33"><a href="#cb16-33"></a>    <span class="at">INVID =</span> <span class="fu">factor</span>(INVID),</span>
+<span id="cb16-34"><a href="#cb16-34"></a>    <span class="at">SITEID =</span> <span class="fu">factor</span>(SITEID),</span>
+<span id="cb16-35"><a href="#cb16-35"></a>    <span class="at">INVNAM =</span> <span class="fu">factor</span>(INVNAM),</span>
+<span id="cb16-36"><a href="#cb16-36"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">factor</span>(INVID_INVNAM)</span>
+<span id="cb16-37"><a href="#cb16-37"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-38"><a href="#cb16-38"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb16-39"><a href="#cb16-39"></a>    <span class="at">INVID_INVNAM =</span> <span class="st">"Investigator Number/Name"</span>,</span>
+<span id="cb16-40"><a href="#cb16-40"></a>    <span class="at">REGION1 =</span> <span class="st">"Geographic Region 1"</span>,</span>
+<span id="cb16-41"><a href="#cb16-41"></a>    <span class="at">COUNTRY =</span> <span class="st">"Country"</span>,</span>
+<span id="cb16-42"><a href="#cb16-42"></a>    <span class="at">INVID =</span> <span class="st">"Investigator Identifier"</span></span>
+<span id="cb16-43"><a href="#cb16-43"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-44"><a href="#cb16-44"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY, INVID)</span>
+<span id="cb16-45"><a href="#cb16-45"></a><span class="in">```</span></span>
+<span id="cb16-46"><a href="#cb16-46"></a></span>
+<span id="cb16-47"><a href="#cb16-47"></a><span class="fu">## ENT01 -- Enrollment by Region, &lt;br/&gt; Country, and Investigator Number</span></span>
+<span id="cb16-48"><a href="#cb16-48"></a></span>
+<span id="cb16-49"><a href="#cb16-49"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb16-50"><a href="#cb16-50"></a><span class="co"># Define the split function</span></span>
+<span id="cb16-51"><a href="#cb16-51"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb16-52"><a href="#cb16-52"></a></span>
+<span id="cb16-53"><a href="#cb16-53"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-54"><a href="#cb16-54"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-55"><a href="#cb16-55"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-56"><a href="#cb16-56"></a>  <span class="fu">split_rows_by</span>(<span class="st">"REGION1"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>REGION1)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-57"><a href="#cb16-57"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-58"><a href="#cb16-58"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-59"><a href="#cb16-59"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-60"><a href="#cb16-60"></a>  <span class="fu">analyze</span>(<span class="st">"INVID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-61"><a href="#cb16-61"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID"</span>, 2L)</span>
+<span id="cb16-62"><a href="#cb16-62"></a></span>
+<span id="cb16-63"><a href="#cb16-63"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-64"><a href="#cb16-64"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-65"><a href="#cb16-65"></a></span>
+<span id="cb16-66"><a href="#cb16-66"></a>result</span>
+<span id="cb16-67"><a href="#cb16-67"></a><span class="in">```</span></span>
+<span id="cb16-68"><a href="#cb16-68"></a></span>
+<span id="cb16-69"><a href="#cb16-69"></a><span class="fu">## ENT01A -- Enrollment by Country &lt;br/&gt; and Investigator Number</span></span>
+<span id="cb16-70"><a href="#cb16-70"></a></span>
+<span id="cb16-71"><a href="#cb16-71"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb16-72"><a href="#cb16-72"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-73"><a href="#cb16-73"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-74"><a href="#cb16-74"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-75"><a href="#cb16-75"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-76"><a href="#cb16-76"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-77"><a href="#cb16-77"></a>  <span class="fu">analyze</span>(<span class="st">"INVID"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-78"><a href="#cb16-78"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID"</span>, 1L)</span>
+<span id="cb16-79"><a href="#cb16-79"></a></span>
+<span id="cb16-80"><a href="#cb16-80"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-81"><a href="#cb16-81"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-82"><a href="#cb16-82"></a></span>
+<span id="cb16-83"><a href="#cb16-83"></a>result</span>
+<span id="cb16-84"><a href="#cb16-84"></a><span class="in">```</span></span>
+<span id="cb16-85"><a href="#cb16-85"></a></span>
+<span id="cb16-86"><a href="#cb16-86"></a><span class="fu">## ENT02 -- Enrollment by Region, Country, &lt;br/&gt; and Investigator Number/Name</span></span>
+<span id="cb16-87"><a href="#cb16-87"></a></span>
+<span id="cb16-88"><a href="#cb16-88"></a><span class="in">```{r variant3, test = list(result_v3 = "result")}</span></span>
+<span id="cb16-89"><a href="#cb16-89"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-90"><a href="#cb16-90"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-91"><a href="#cb16-91"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-92"><a href="#cb16-92"></a>  <span class="fu">split_rows_by</span>(<span class="st">"REGION1"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>REGION1)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-93"><a href="#cb16-93"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-94"><a href="#cb16-94"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-95"><a href="#cb16-95"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-96"><a href="#cb16-96"></a>  <span class="fu">analyze</span>(<span class="st">"INVID_INVNAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-97"><a href="#cb16-97"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID_INVNAM"</span>, 2L)</span>
+<span id="cb16-98"><a href="#cb16-98"></a></span>
+<span id="cb16-99"><a href="#cb16-99"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-100"><a href="#cb16-100"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-101"><a href="#cb16-101"></a></span>
+<span id="cb16-102"><a href="#cb16-102"></a>result</span>
+<span id="cb16-103"><a href="#cb16-103"></a><span class="in">```</span></span>
+<span id="cb16-104"><a href="#cb16-104"></a></span>
+<span id="cb16-105"><a href="#cb16-105"></a><span class="fu">## ENT02A -- Enrollment by Country &lt;br/&gt; and Investigator Number/Name</span></span>
+<span id="cb16-106"><a href="#cb16-106"></a></span>
+<span id="cb16-107"><a href="#cb16-107"></a><span class="in">```{r variant4, test = list(result_v4 = "result")}</span></span>
+<span id="cb16-108"><a href="#cb16-108"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-109"><a href="#cb16-109"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-110"><a href="#cb16-110"></a>  <span class="fu">add_overall_col</span>(<span class="at">label =</span> <span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-111"><a href="#cb16-111"></a>  <span class="fu">split_rows_by</span>(<span class="st">"COUNTRY"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(adsl<span class="sc">$</span>COUNTRY)) <span class="sc">%&gt;%</span></span>
+<span id="cb16-112"><a href="#cb16-112"></a>  <span class="fu">summarize_row_groups</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb16-113"><a href="#cb16-113"></a>  <span class="fu">analyze</span>(<span class="st">"INVID_INVNAM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb16-114"><a href="#cb16-114"></a>  <span class="fu">append_varlabels</span>(adsl, <span class="st">"INVID_INVNAM"</span>, 1L)</span>
+<span id="cb16-115"><a href="#cb16-115"></a></span>
+<span id="cb16-116"><a href="#cb16-116"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(lyt, adsl) <span class="sc">%&gt;%</span></span>
+<span id="cb16-117"><a href="#cb16-117"></a>  <span class="fu">prune_table</span>()</span>
+<span id="cb16-118"><a href="#cb16-118"></a></span>
+<span id="cb16-119"><a href="#cb16-119"></a>result</span>
+<span id="cb16-120"><a href="#cb16-120"></a><span class="in">```</span></span>
+<span id="cb16-121"><a href="#cb16-121"></a></span>
+<span id="cb16-122"><a href="#cb16-122"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb16-123"><a href="#cb16-123"></a></span>
+<span id="cb16-124"><a href="#cb16-124"></a><span class="fu">## `teal` App</span></span>
+<span id="cb16-125"><a href="#cb16-125"></a></span>
+<span id="cb16-126"><a href="#cb16-126"></a>Note that for this module application, only the variables passed into <span class="in">`by_vars`</span> are used when <span class="in">`row_groups`</span> is selected.</span>
+<span id="cb16-127"><a href="#cb16-127"></a>Variables passed into <span class="in">`analyze_vars`</span> are additionally used when <span class="in">`row_groups`</span> is deselected.</span>
+<span id="cb16-128"><a href="#cb16-128"></a></span>
+<span id="cb16-129"><a href="#cb16-129"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb16-130"><a href="#cb16-130"></a><span class="co">#| screenshot.opts = list(delay = 8)</span></span>
+<span id="cb16-131"><a href="#cb16-131"></a></span>
+<span id="cb16-132"><a href="#cb16-132"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb16-133"><a href="#cb16-133"></a><span class="fu">library</span>(forcats)</span>
+<span id="cb16-134"><a href="#cb16-134"></a><span class="fu">library</span>(scda)</span>
+<span id="cb16-135"><a href="#cb16-135"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb16-136"><a href="#cb16-136"></a></span>
+<span id="cb16-137"><a href="#cb16-137"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb16-138"><a href="#cb16-138"></a></span>
+<span id="cb16-139"><a href="#cb16-139"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb16-140"><a href="#cb16-140"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb16-141"><a href="#cb16-141"></a></span>
+<span id="cb16-142"><a href="#cb16-142"></a>adsl_labels <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(adsl)</span>
+<span id="cb16-143"><a href="#cb16-143"></a></span>
+<span id="cb16-144"><a href="#cb16-144"></a>adsl <span class="ot">&lt;-</span> adsl <span class="sc">%&gt;%</span></span>
+<span id="cb16-145"><a href="#cb16-145"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-146"><a href="#cb16-146"></a>    <span class="at">REGION1 =</span> <span class="fu">droplevels</span>(REGION1),</span>
+<span id="cb16-147"><a href="#cb16-147"></a>    <span class="at">COUNTRY =</span> <span class="fu">droplevels</span>(COUNTRY),</span>
+<span id="cb16-148"><a href="#cb16-148"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">paste</span>(INVID, INVNAM, <span class="at">sep =</span> <span class="st">" / "</span>)</span>
+<span id="cb16-149"><a href="#cb16-149"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb16-150"><a href="#cb16-150"></a>  <span class="fu">arrange</span>(REGION1, COUNTRY, INVID) <span class="sc">%&gt;%</span></span>
+<span id="cb16-151"><a href="#cb16-151"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb16-152"><a href="#cb16-152"></a>    <span class="at">INVID =</span> <span class="fu">factor</span>(INVID),</span>
+<span id="cb16-153"><a href="#cb16-153"></a>    <span class="at">SITEID =</span> <span class="fu">factor</span>(SITEID),</span>
+<span id="cb16-154"><a href="#cb16-154"></a>    <span class="at">INVNAM =</span> <span class="fu">factor</span>(INVNAM),</span>
+<span id="cb16-155"><a href="#cb16-155"></a>    <span class="at">INVID_INVNAM =</span> <span class="fu">factor</span>(INVID_INVNAM)</span>
+<span id="cb16-156"><a href="#cb16-156"></a>  )</span>
+<span id="cb16-157"><a href="#cb16-157"></a></span>
+<span id="cb16-158"><a href="#cb16-158"></a><span class="fu">var_labels</span>(adsl) <span class="ot">&lt;-</span> <span class="fu">c</span>(adsl_labels, <span class="st">"Investigator Number/Name"</span>)</span>
+<span id="cb16-159"><a href="#cb16-159"></a></span>
+<span id="cb16-160"><a href="#cb16-160"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb16-161"><a href="#cb16-161"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb16-162"><a href="#cb16-162"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl,</span>
+<span id="cb16-163"><a href="#cb16-163"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- df_explicit_na(synthetic_cdisc_dataset("latest", "adsl"))</span></span>
+<span id="cb16-164"><a href="#cb16-164"></a><span class="st">                  ADSL_labels &lt;- var_labels(ADSL)</span></span>
+<span id="cb16-165"><a href="#cb16-165"></a><span class="st">                  ADSL &lt;- ADSL %&gt;% mutate(</span></span>
+<span id="cb16-166"><a href="#cb16-166"></a><span class="st">                    REGION1 = droplevels(REGION1),</span></span>
+<span id="cb16-167"><a href="#cb16-167"></a><span class="st">                    COUNTRY = droplevels(COUNTRY),</span></span>
+<span id="cb16-168"><a href="#cb16-168"></a><span class="st">                    INVID_INVNAM = paste(INVID, INVNAM, sep = " / ")</span></span>
+<span id="cb16-169"><a href="#cb16-169"></a><span class="st">                  ) %&gt;%</span></span>
+<span id="cb16-170"><a href="#cb16-170"></a><span class="st">                    arrange(REGION1, COUNTRY, INVID) %&gt;%</span></span>
+<span id="cb16-171"><a href="#cb16-171"></a><span class="st">                    mutate(</span></span>
+<span id="cb16-172"><a href="#cb16-172"></a><span class="st">                      INVID = factor(INVID),</span></span>
+<span id="cb16-173"><a href="#cb16-173"></a><span class="st">                      SITEID = factor(SITEID),</span></span>
+<span id="cb16-174"><a href="#cb16-174"></a><span class="st">                      INVNAM = factor(INVNAM),</span></span>
+<span id="cb16-175"><a href="#cb16-175"></a><span class="st">                      INVID_INVNAM = factor(INVID_INVNAM)</span></span>
+<span id="cb16-176"><a href="#cb16-176"></a><span class="st">                    )</span></span>
+<span id="cb16-177"><a href="#cb16-177"></a></span>
+<span id="cb16-178"><a href="#cb16-178"></a><span class="st">                  var_labels(ADSL) &lt;- c(ADSL_labels, "Investigator Number/Name")'</span></span>
+<span id="cb16-179"><a href="#cb16-179"></a>    ),</span>
+<span id="cb16-180"><a href="#cb16-180"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-181"><a href="#cb16-181"></a>  ),</span>
+<span id="cb16-182"><a href="#cb16-182"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb16-183"><a href="#cb16-183"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb16-184"><a href="#cb16-184"></a>      <span class="at">label =</span> <span class="st">"Enrollment Table"</span>,</span>
+<span id="cb16-185"><a href="#cb16-185"></a>      <span class="at">dataname =</span> <span class="st">"ADSL"</span>,</span>
+<span id="cb16-186"><a href="#cb16-186"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-187"><a href="#cb16-187"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb16-188"><a href="#cb16-188"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb16-189"><a href="#cb16-189"></a>      ),</span>
+<span id="cb16-190"><a href="#cb16-190"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-191"><a href="#cb16-191"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"REGION1"</span>, <span class="st">"COUNTRY"</span>, <span class="st">"SITEID"</span>, <span class="st">"INVID"</span>, <span class="st">"INVNAM"</span>, <span class="st">"INVID_INVNAM"</span>)),</span>
+<span id="cb16-192"><a href="#cb16-192"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"REGION1"</span>)</span>
+<span id="cb16-193"><a href="#cb16-193"></a>      ),</span>
+<span id="cb16-194"><a href="#cb16-194"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-195"><a href="#cb16-195"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"REGION1"</span>, <span class="st">"COUNTRY"</span>, <span class="st">"SITEID"</span>, <span class="st">"INVID"</span>, <span class="st">"INVNAM"</span>, <span class="st">"INVID_INVNAM"</span>)),</span>
+<span id="cb16-196"><a href="#cb16-196"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"SITEID"</span>)</span>
+<span id="cb16-197"><a href="#cb16-197"></a>      ),</span>
+<span id="cb16-198"><a href="#cb16-198"></a>      <span class="at">denominator =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb16-199"><a href="#cb16-199"></a>        <span class="at">choices =</span> <span class="fu">c</span>(<span class="st">"n"</span>, <span class="st">"N"</span>, <span class="st">"omit"</span>),</span>
+<span id="cb16-200"><a href="#cb16-200"></a>        <span class="at">selected =</span> <span class="st">"N"</span>,</span>
+<span id="cb16-201"><a href="#cb16-201"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-202"><a href="#cb16-202"></a>      ),</span>
+<span id="cb16-203"><a href="#cb16-203"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb16-204"><a href="#cb16-204"></a>      <span class="at">row_groups =</span> <span class="cn">TRUE</span></span>
+<span id="cb16-205"><a href="#cb16-205"></a>    )</span>
+<span id="cb16-206"><a href="#cb16-206"></a>  )</span>
+<span id="cb16-207"><a href="#cb16-207"></a>)</span>
+<span id="cb16-208"><a href="#cb16-208"></a></span>
+<span id="cb16-209"><a href="#cb16-209"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb16-210"><a href="#cb16-210"></a><span class="in">```</span></span>
+<span id="cb16-211"><a href="#cb16-211"></a></span>
+<span id="cb16-212"><a href="#cb16-212"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb16-213"><a href="#cb16-213"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="true">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">VST01</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Vital Sign Results and Change from Baseline by Visit</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">Standard Table</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="vst01_cache/html/setup_295267da4eb16c947aaa33c6b9144735">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb1-5"><a href="#cb1-5"></a></span>
+<span id="cb1-6"><a href="#cb1-6"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a>advs_label <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(advs)</span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a>advs <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">filter</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DIABP"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    PARAM <span class="sc">==</span> <span class="st">"Diastolic Blood Pressure"</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb1-21"><a href="#cb1-21"></a>    <span class="at">PARAMCD =</span> <span class="fu">droplevels</span>(PARAMCD),</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">PARAM =</span> <span class="fu">droplevels</span>(PARAM)</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  )</span>
+<span id="cb1-24"><a href="#cb1-24"></a></span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="co"># post-baseline</span></span>
+<span id="cb1-26"><a href="#cb1-26"></a>advs_pb <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a>  <span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>, ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>)</span>
+<span id="cb1-28"><a href="#cb1-28"></a></span>
+<span id="cb1-29"><a href="#cb1-29"></a>advs_pb_max <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb1-30"><a href="#cb1-30"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-32"><a href="#cb1-32"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-34"><a href="#cb1-34"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Maximum"</span>)</span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a>advs_pb_min <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-38"><a href="#cb1-38"></a>  <span class="fu">arrange</span>(AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-40"><a href="#cb1-40"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Minimum"</span>)</span>
+<span id="cb1-42"><a href="#cb1-42"></a></span>
+<span id="cb1-43"><a href="#cb1-43"></a>advs_pb_last <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb1-44"><a href="#cb1-44"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVISITN)) <span class="sc">%&gt;%</span></span>
+<span id="cb1-46"><a href="#cb1-46"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb1-48"><a href="#cb1-48"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Last"</span>)</span>
+<span id="cb1-49"><a href="#cb1-49"></a></span>
+<span id="cb1-50"><a href="#cb1-50"></a><span class="co"># Please note that for real data, per ADaM Spec 1.1, the advs_f can be obtained by filtering on PARAMCD, then</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a><span class="co"># ANL01FL == 'Y' or AVISIT in c('POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST')</span></span>
+<span id="cb1-52"><a href="#cb1-52"></a></span>
+<span id="cb1-53"><a href="#cb1-53"></a>advs_f <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb1-54"><a href="#cb1-54"></a>  advs,</span>
+<span id="cb1-55"><a href="#cb1-55"></a>  advs_pb_last,</span>
+<span id="cb1-56"><a href="#cb1-56"></a>  advs_pb_min,</span>
+<span id="cb1-57"><a href="#cb1-57"></a>  advs_pb_max</span>
+<span id="cb1-58"><a href="#cb1-58"></a>)</span>
+<span id="cb1-59"><a href="#cb1-59"></a></span>
+<span id="cb1-60"><a href="#cb1-60"></a>advs_f <span class="ot">&lt;-</span> advs_f <span class="sc">%&gt;%</span></span>
+<span id="cb1-61"><a href="#cb1-61"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT))</span>
+<span id="cb1-62"><a href="#cb1-62"></a></span>
+<span id="cb1-63"><a href="#cb1-63"></a><span class="fu">var_labels</span>(advs_f) <span class="ot">&lt;-</span> advs_label</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="vst01_cache/html/variant1_50d889237bbbdf332b4ae5bc178b18e9">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb2-2"><a href="#cb2-2"></a></span>
+<span id="cb2-3"><a href="#cb2-3"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb2-4"><a href="#cb2-4"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb2-8"><a href="#cb2-8"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb2-9"><a href="#cb2-9"></a>  } <span class="cf">else</span> {</span>
+<span id="cb2-10"><a href="#cb2-10"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb2-11"><a href="#cb2-11"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb2-12"><a href="#cb2-12"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb2-13"><a href="#cb2-13"></a>  }</span>
+<span id="cb2-14"><a href="#cb2-14"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb2-15"><a href="#cb2-15"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb2-16"><a href="#cb2-16"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb2-17"><a href="#cb2-17"></a></span>
+<span id="cb2-18"><a href="#cb2-18"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb2-19"><a href="#cb2-19"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb2-20"><a href="#cb2-20"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb2-21"><a href="#cb2-21"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb2-22"><a href="#cb2-22"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb2-23"><a href="#cb2-23"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb2-24"><a href="#cb2-24"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb2-25"><a href="#cb2-25"></a>  )</span>
+<span id="cb2-26"><a href="#cb2-26"></a>}</span>
+<span id="cb2-27"><a href="#cb2-27"></a></span>
+<span id="cb2-28"><a href="#cb2-28"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-29"><a href="#cb2-29"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-30"><a href="#cb2-30"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n\n</span><span class="st">Analysis Visit"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-31"><a href="#cb2-31"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb2-32"><a href="#cb2-32"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb2-33"><a href="#cb2-33"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb2-34"><a href="#cb2-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-35"><a href="#cb2-35"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb2-36"><a href="#cb2-36"></a></span>
+<span id="cb2-37"><a href="#cb2-37"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-38"><a href="#cb2-38"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>                                   A: Drug X                        B: Placebo                      C: Combination         
+                                          Change from                       Change from                       Change from  
+Analysis Visit          Value at Visit      Baseline      Value at Visit      Baseline      Value at Visit      Baseline   
+                           (N=134)          (N=134)          (N=134)          (N=134)          (N=132)          (N=132)    
+———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
+SCREENING                                                                                                                  
+  n                          134               0               134               0               132               0       
+  Mean (SD)             99.92 (17.99)       NE (NE)       101.88 (21.07)      NE (NE)       100.48 (19.07)      NE (NE)    
+  Median                    99.26              NE             100.22             NE             99.10              NE      
+  Min - Max             54.22 - 152.98      NE - NE       48.15 - 148.03      NE - NE       42.22 - 149.95      NE - NE    
+BASELINE                                                                                                                   
+  n                          134                               134                               132                       
+  Mean (SD)             96.50 (19.90)                     101.10 (19.87)                    102.77 (19.48)                 
+  Median                    96.05                             100.45                            102.01                     
+  Min - Max             44.28 - 136.59                    29.21 - 143.77                    49.37 - 153.50                 
+WEEK 1 DAY 8                                                                                                               
+  n                          134              134              134              134              132              132      
+  Mean (SD)             100.65 (18.79)    4.14 (26.93)    99.19 (19.36)    -1.92 (27.37)    97.14 (19.72)    -5.63 (25.95) 
+  Median                    100.22            1.52            99.37            -2.79            94.19            -5.57     
+  Min - Max             57.60 - 147.46   -50.92 - 74.84   59.28 - 141.21   -64.50 - 70.93   50.98 - 142.47   -55.15 - 56.11
+WEEK 2 DAY 15                                                                                                              
+  n                          134              134              134              134              132              132      
+  Mean (SD)             102.09 (19.62)    5.58 (29.38)    99.29 (21.11)    -1.81 (31.11)    99.95 (20.85)    -2.81 (29.10) 
+  Median                    103.59            7.82            100.57           -1.77            102.52           -5.68     
+  Min - Max             54.73 - 150.85   -59.71 - 98.08   51.60 - 145.28   -71.00 - 92.43   37.06 - 138.92   -73.10 - 76.80
+WEEK 3 DAY 22                                                                                                              
+  n                          134              134              134              134              132              132      
+  Mean (SD)             101.78 (19.54)    5.28 (27.16)    97.73 (19.85)    -3.37 (27.76)    99.86 (19.15)    -2.91 (27.25) 
+  Median                    100.39            6.53            98.83            -5.79            100.06           -1.54     
+  Min - Max             47.68 - 162.22   -64.46 - 76.64   36.25 - 142.78   -70.23 - 84.74   53.80 - 146.37   -74.30 - 67.46
+WEEK 4 DAY 29                                                                                                              
+  n                          134              134              134              134              132              132      
+  Mean (SD)             100.18 (20.18)    3.68 (27.21)    99.06 (17.75)    -2.04 (26.59)    99.27 (20.12)    -3.50 (27.62) 
+  Median                    98.17             3.00            97.98            -1.89            99.61            -0.46     
+  Min - Max             48.52 - 153.41   -77.30 - 61.90   56.78 - 142.45   -82.96 - 89.87   46.87 - 146.12   -88.68 - 70.90
+WEEK 5 DAY 36                                                                                                              
+  n                          134              134              134              134              132              132      
+  Mean (SD)             101.42 (18.83)    4.92 (28.02)    95.92 (19.90)    -5.19 (29.34)    97.73 (18.92)    -5.04 (26.64) 
+  Median                    98.56             3.93            94.30            -7.18            98.09            -5.62     
+  Min - Max             62.66 - 155.52   -63.05 - 78.66   51.06 - 151.52   -78.07 - 72.91   51.48 - 157.27   -76.13 - 86.42
+Post-Baseline Last                                                                                                         
+  n                          134              134              134              134              132              132      
+  Mean (SD)             101.42 (18.83)    4.92 (28.02)    95.92 (19.90)    -5.19 (29.34)    97.73 (18.92)    -5.04 (26.64) 
+  Median                    98.56             3.93            94.30            -7.18            98.09            -5.62     
+  Min - Max             62.66 - 155.52   -63.05 - 78.66   51.06 - 151.52   -78.07 - 72.91   51.48 - 157.27   -76.13 - 86.42
+Post-Baseline Minimum                                                                                                      
+  n                          134              134              134              134              132              132      
+  Mean (SD)             78.98 (11.94)    -17.52 (23.92)   75.77 (13.25)    -25.33 (25.39)   76.35 (13.13)    -26.41 (22.78)
+  Median                    80.14            -13.96           75.71            -26.70           76.26            -27.17    
+  Min - Max             47.68 - 110.54   -77.30 - 33.00   36.25 - 113.53   -82.96 - 69.23   37.06 - 112.35   -88.68 - 34.24
+Post-Baseline Maximum                                                                                                      
+  n                          134              134              134              134              132              132      
+  Mean (SD)             125.08 (12.28)   28.57 (23.20)    121.33 (12.01)   20.23 (23.64)    121.42 (12.09)   18.65 (22.74) 
+  Median                    124.20           29.14            120.80           18.74            122.55           16.93     
+  Min - Max             94.06 - 162.22   -21.49 - 98.08   94.43 - 151.52   -34.95 - 92.43   79.39 - 157.27   -43.32 - 86.42</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:30}" data-hash="vst01_cache/html/teal_8315b39bbef5f85f16607ad3f34cfec8">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb4-2"><a href="#cb4-2"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb4-3"><a href="#cb4-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb4-4"><a href="#cb4-4"></a></span>
+<span id="cb4-5"><a href="#cb4-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb4-6"><a href="#cb4-6"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb4-7"><a href="#cb4-7"></a>advs_label <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(advs)</span>
+<span id="cb4-8"><a href="#cb4-8"></a></span>
+<span id="cb4-9"><a href="#cb4-9"></a><span class="co"># post-baseline</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>advs_pb <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb4-11"><a href="#cb4-11"></a>  <span class="fu">filter</span>(</span>
+<span id="cb4-12"><a href="#cb4-12"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb4-13"><a href="#cb4-13"></a>    ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span></span>
+<span id="cb4-14"><a href="#cb4-14"></a>  )</span>
+<span id="cb4-15"><a href="#cb4-15"></a></span>
+<span id="cb4-16"><a href="#cb4-16"></a>advs_pb_max <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb4-17"><a href="#cb4-17"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb4-18"><a href="#cb4-18"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-19"><a href="#cb4-19"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-20"><a href="#cb4-20"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-21"><a href="#cb4-21"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Maximum"</span>)</span>
+<span id="cb4-22"><a href="#cb4-22"></a></span>
+<span id="cb4-23"><a href="#cb4-23"></a>advs_pb_min <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb4-24"><a href="#cb4-24"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb4-25"><a href="#cb4-25"></a>  <span class="fu">arrange</span>(AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb4-26"><a href="#cb4-26"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-27"><a href="#cb4-27"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-28"><a href="#cb4-28"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Minimum"</span>)</span>
+<span id="cb4-29"><a href="#cb4-29"></a></span>
+<span id="cb4-30"><a href="#cb4-30"></a>advs_pb_last <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb4-31"><a href="#cb4-31"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb4-32"><a href="#cb4-32"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVISITN)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-33"><a href="#cb4-33"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-34"><a href="#cb4-34"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb4-35"><a href="#cb4-35"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Last"</span>)</span>
+<span id="cb4-36"><a href="#cb4-36"></a></span>
+<span id="cb4-37"><a href="#cb4-37"></a>advs_f <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb4-38"><a href="#cb4-38"></a>  advs,</span>
+<span id="cb4-39"><a href="#cb4-39"></a>  advs_pb_last,</span>
+<span id="cb4-40"><a href="#cb4-40"></a>  advs_pb_min,</span>
+<span id="cb4-41"><a href="#cb4-41"></a>  advs_pb_max</span>
+<span id="cb4-42"><a href="#cb4-42"></a>)</span>
+<span id="cb4-43"><a href="#cb4-43"></a></span>
+<span id="cb4-44"><a href="#cb4-44"></a>advs_f <span class="ot">&lt;-</span> advs_f <span class="sc">%&gt;%</span></span>
+<span id="cb4-45"><a href="#cb4-45"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT))</span>
+<span id="cb4-46"><a href="#cb4-46"></a></span>
+<span id="cb4-47"><a href="#cb4-47"></a><span class="fu">var_labels</span>(advs_f) <span class="ot">&lt;-</span> advs_label</span>
+<span id="cb4-48"><a href="#cb4-48"></a></span>
+<span id="cb4-49"><a href="#cb4-49"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb4-50"><a href="#cb4-50"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb4-51"><a href="#cb4-51"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb4-52"><a href="#cb4-52"></a>      adsl,</span>
+<span id="cb4-53"><a href="#cb4-53"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb4-54"><a href="#cb4-54"></a>    ),</span>
+<span id="cb4-55"><a href="#cb4-55"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADVS"</span>,</span>
+<span id="cb4-56"><a href="#cb4-56"></a>      advs_f,</span>
+<span id="cb4-57"><a href="#cb4-57"></a>      <span class="at">code =</span> <span class="st">'ADVS &lt;- synthetic_cdisc_dataset("latest", "advs")</span></span>
+<span id="cb4-58"><a href="#cb4-58"></a><span class="st">                  ADVS_label &lt;- var_labels(ADVS)</span></span>
+<span id="cb4-59"><a href="#cb4-59"></a></span>
+<span id="cb4-60"><a href="#cb4-60"></a><span class="st">                  # post-baseline</span></span>
+<span id="cb4-61"><a href="#cb4-61"></a><span class="st">                  ADVS_pb &lt;- ADVS %&gt;%</span></span>
+<span id="cb4-62"><a href="#cb4-62"></a><span class="st">                    filter(</span></span>
+<span id="cb4-63"><a href="#cb4-63"></a><span class="st">                      ABLFL != "Y",</span></span>
+<span id="cb4-64"><a href="#cb4-64"></a><span class="st">                      ABLFL2 != "Y"</span></span>
+<span id="cb4-65"><a href="#cb4-65"></a><span class="st">                    )</span></span>
+<span id="cb4-66"><a href="#cb4-66"></a></span>
+<span id="cb4-67"><a href="#cb4-67"></a><span class="st">                  ADVS_pb_max &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb4-68"><a href="#cb4-68"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb4-69"><a href="#cb4-69"></a><span class="st">                    arrange(desc(AVAL)) %&gt;%</span></span>
+<span id="cb4-70"><a href="#cb4-70"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb4-71"><a href="#cb4-71"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb4-72"><a href="#cb4-72"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Maximum")</span></span>
+<span id="cb4-73"><a href="#cb4-73"></a></span>
+<span id="cb4-74"><a href="#cb4-74"></a><span class="st">                  ADVS_pb_min &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb4-75"><a href="#cb4-75"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb4-76"><a href="#cb4-76"></a><span class="st">                    arrange(AVAL) %&gt;%</span></span>
+<span id="cb4-77"><a href="#cb4-77"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb4-78"><a href="#cb4-78"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb4-79"><a href="#cb4-79"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Minimum")</span></span>
+<span id="cb4-80"><a href="#cb4-80"></a></span>
+<span id="cb4-81"><a href="#cb4-81"></a><span class="st">                  ADVS_pb_last &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb4-82"><a href="#cb4-82"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb4-83"><a href="#cb4-83"></a><span class="st">                    arrange(desc(AVISITN)) %&gt;%</span></span>
+<span id="cb4-84"><a href="#cb4-84"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb4-85"><a href="#cb4-85"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb4-86"><a href="#cb4-86"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Last")</span></span>
+<span id="cb4-87"><a href="#cb4-87"></a></span>
+<span id="cb4-88"><a href="#cb4-88"></a><span class="st">                  ADVS_f &lt;- rbind(</span></span>
+<span id="cb4-89"><a href="#cb4-89"></a><span class="st">                    ADVS,</span></span>
+<span id="cb4-90"><a href="#cb4-90"></a><span class="st">                    ADVS_pb_last,</span></span>
+<span id="cb4-91"><a href="#cb4-91"></a><span class="st">                    ADVS_pb_min,</span></span>
+<span id="cb4-92"><a href="#cb4-92"></a><span class="st">                    ADVS_pb_max</span></span>
+<span id="cb4-93"><a href="#cb4-93"></a><span class="st">                  )</span></span>
+<span id="cb4-94"><a href="#cb4-94"></a></span>
+<span id="cb4-95"><a href="#cb4-95"></a><span class="st">                  ADVS &lt;- ADVS_f %&gt;%</span></span>
+<span id="cb4-96"><a href="#cb4-96"></a><span class="st">                    mutate(AVISIT = droplevels(AVISIT))</span></span>
+<span id="cb4-97"><a href="#cb4-97"></a><span class="st">                  var_labels(ADVS) &lt;- ADVS_label'</span></span>
+<span id="cb4-98"><a href="#cb4-98"></a>    ),</span>
+<span id="cb4-99"><a href="#cb4-99"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-100"><a href="#cb4-100"></a>  ),</span>
+<span id="cb4-101"><a href="#cb4-101"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb4-102"><a href="#cb4-102"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb4-103"><a href="#cb4-103"></a>      <span class="at">label =</span> <span class="st">"Vital Sign Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb4-104"><a href="#cb4-104"></a>      <span class="at">dataname =</span> <span class="st">"ADVS"</span>,</span>
+<span id="cb4-105"><a href="#cb4-105"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-106"><a href="#cb4-106"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb4-107"><a href="#cb4-107"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb4-108"><a href="#cb4-108"></a>      ),</span>
+<span id="cb4-109"><a href="#cb4-109"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-110"><a href="#cb4-110"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb4-111"><a href="#cb4-111"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"PARAM"</span>)</span>
+<span id="cb4-112"><a href="#cb4-112"></a>      ),</span>
+<span id="cb4-113"><a href="#cb4-113"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-114"><a href="#cb4-114"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb4-115"><a href="#cb4-115"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb4-116"><a href="#cb4-116"></a>      ),</span>
+<span id="cb4-117"><a href="#cb4-117"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb4-118"><a href="#cb4-118"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb4-119"><a href="#cb4-119"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(advs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb4-120"><a href="#cb4-120"></a>        <span class="at">selected =</span> <span class="st">"DIABP"</span></span>
+<span id="cb4-121"><a href="#cb4-121"></a>      ),</span>
+<span id="cb4-122"><a href="#cb4-122"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-123"><a href="#cb4-123"></a>    )</span>
+<span id="cb4-124"><a href="#cb4-124"></a>  ),</span>
+<span id="cb4-125"><a href="#cb4-125"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADVS =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb4-126"><a href="#cb4-126"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:06:29.2573 pid:8525 token:[] teal.modules.clinical Initializing tm_t_summary_by</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="vst01_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="vst01_cache/html/sessioninfo_3988f4496c6e65a49af509261ebb4c3a">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb7"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb7-1"><a href="#cb7-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] dplyr_1.1.3                  scda_0.1.6                  
+ [9] tern_0.9.0                   rtables_0.6.3               
+[11] magrittr_2.0.3               formatters_0.5.2            
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        sass_0.4.7           
+[16] rlang_1.1.1           tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] bslib_0.5.1           httpuv_1.6.11         Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="vst01_cache/html/snapshot_796378f187635e6bf17484bac069db36">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-2"><a href="#cb9-2"></a></span>
+<span id="cb9-3"><a href="#cb9-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb9-4"><a href="#cb9-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb9-5"><a href="#cb9-5"></a></span>
+<span id="cb9-6"><a href="#cb9-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb9-7"><a href="#cb9-7"></a></span>
+<span id="cb9-8"><a href="#cb9-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb9-9"><a href="#cb9-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb9-10"><a href="#cb9-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb9-11"><a href="#cb9-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/vital-signs/vst01.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
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+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
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+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
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+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
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+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
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+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
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+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
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+              parent.appendChild(div);
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+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
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+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
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+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
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+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
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+      if (cites) {
+        return {
+          el,
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+        };
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+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
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+            citeDiv.innerHTML = biblioDiv.innerHTML;
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+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
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+        <i class="bi bi-arrow-left-short"></i> <span class="nav-page-text">ENTXX</span>
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+  <div class="nav-page nav-page-next">
+      <a href="../../tables/vital-signs/vst02.html" class="pagination-link">
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+  </div>
+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb10" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb10-1"><a href="#cb10-1"></a><span class="co">---</span></span>
+<span id="cb10-2"><a href="#cb10-2"></a><span class="an">title:</span><span class="co"> VST01</span></span>
+<span id="cb10-3"><a href="#cb10-3"></a><span class="an">subtitle:</span><span class="co"> Vital Sign Results and Change from Baseline by Visit</span></span>
+<span id="cb10-4"><a href="#cb10-4"></a><span class="co">---</span></span>
+<span id="cb10-5"><a href="#cb10-5"></a></span>
+<span id="cb10-6"><a href="#cb10-6"></a>------------------------------------------------------------------------</span>
+<span id="cb10-7"><a href="#cb10-7"></a></span>
+<span id="cb10-8"><a href="#cb10-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb10-9"><a href="#cb10-9"></a></span>
+<span id="cb10-10"><a href="#cb10-10"></a>::: panel-tabset</span>
+<span id="cb10-11"><a href="#cb10-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb10-12"><a href="#cb10-12"></a></span>
+<span id="cb10-13"><a href="#cb10-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb10-14"><a href="#cb10-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb10-15"><a href="#cb10-15"></a></span>
+<span id="cb10-16"><a href="#cb10-16"></a><span class="fu">library</span>(tern)</span>
+<span id="cb10-17"><a href="#cb10-17"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-18"><a href="#cb10-18"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-19"><a href="#cb10-19"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-20"><a href="#cb10-20"></a></span>
+<span id="cb10-21"><a href="#cb10-21"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-22"><a href="#cb10-22"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb10-23"><a href="#cb10-23"></a></span>
+<span id="cb10-24"><a href="#cb10-24"></a><span class="co"># Ensure character variables are converted to factors and empty strings and NAs are explicit missing levels.</span></span>
+<span id="cb10-25"><a href="#cb10-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb10-26"><a href="#cb10-26"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb10-27"><a href="#cb10-27"></a></span>
+<span id="cb10-28"><a href="#cb10-28"></a>advs_label <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(advs)</span>
+<span id="cb10-29"><a href="#cb10-29"></a></span>
+<span id="cb10-30"><a href="#cb10-30"></a>advs <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb10-31"><a href="#cb10-31"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-32"><a href="#cb10-32"></a>    PARAMCD <span class="sc">==</span> <span class="st">"DIABP"</span>,</span>
+<span id="cb10-33"><a href="#cb10-33"></a>    PARAM <span class="sc">==</span> <span class="st">"Diastolic Blood Pressure"</span></span>
+<span id="cb10-34"><a href="#cb10-34"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-35"><a href="#cb10-35"></a>  <span class="fu">mutate</span>(</span>
+<span id="cb10-36"><a href="#cb10-36"></a>    <span class="at">PARAMCD =</span> <span class="fu">droplevels</span>(PARAMCD),</span>
+<span id="cb10-37"><a href="#cb10-37"></a>    <span class="at">PARAM =</span> <span class="fu">droplevels</span>(PARAM)</span>
+<span id="cb10-38"><a href="#cb10-38"></a>  )</span>
+<span id="cb10-39"><a href="#cb10-39"></a></span>
+<span id="cb10-40"><a href="#cb10-40"></a><span class="co"># post-baseline</span></span>
+<span id="cb10-41"><a href="#cb10-41"></a>advs_pb <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb10-42"><a href="#cb10-42"></a>  <span class="fu">filter</span>(ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>, ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span>)</span>
+<span id="cb10-43"><a href="#cb10-43"></a></span>
+<span id="cb10-44"><a href="#cb10-44"></a>advs_pb_max <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-45"><a href="#cb10-45"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-46"><a href="#cb10-46"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-47"><a href="#cb10-47"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-48"><a href="#cb10-48"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-49"><a href="#cb10-49"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Maximum"</span>)</span>
+<span id="cb10-50"><a href="#cb10-50"></a></span>
+<span id="cb10-51"><a href="#cb10-51"></a>advs_pb_min <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-52"><a href="#cb10-52"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-53"><a href="#cb10-53"></a>  <span class="fu">arrange</span>(AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb10-54"><a href="#cb10-54"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-55"><a href="#cb10-55"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-56"><a href="#cb10-56"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Minimum"</span>)</span>
+<span id="cb10-57"><a href="#cb10-57"></a></span>
+<span id="cb10-58"><a href="#cb10-58"></a>advs_pb_last <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-59"><a href="#cb10-59"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-60"><a href="#cb10-60"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVISITN)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-61"><a href="#cb10-61"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-62"><a href="#cb10-62"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-63"><a href="#cb10-63"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Last"</span>)</span>
+<span id="cb10-64"><a href="#cb10-64"></a></span>
+<span id="cb10-65"><a href="#cb10-65"></a><span class="co"># Please note that for real data, per ADaM Spec 1.1, the advs_f can be obtained by filtering on PARAMCD, then</span></span>
+<span id="cb10-66"><a href="#cb10-66"></a><span class="co"># ANL01FL == 'Y' or AVISIT in c('POST-BASELINE MAXIMUM', 'POST-BASELINE MINIMUM', 'POST-BASELINE LAST')</span></span>
+<span id="cb10-67"><a href="#cb10-67"></a></span>
+<span id="cb10-68"><a href="#cb10-68"></a>advs_f <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb10-69"><a href="#cb10-69"></a>  advs,</span>
+<span id="cb10-70"><a href="#cb10-70"></a>  advs_pb_last,</span>
+<span id="cb10-71"><a href="#cb10-71"></a>  advs_pb_min,</span>
+<span id="cb10-72"><a href="#cb10-72"></a>  advs_pb_max</span>
+<span id="cb10-73"><a href="#cb10-73"></a>)</span>
+<span id="cb10-74"><a href="#cb10-74"></a></span>
+<span id="cb10-75"><a href="#cb10-75"></a>advs_f <span class="ot">&lt;-</span> advs_f <span class="sc">%&gt;%</span></span>
+<span id="cb10-76"><a href="#cb10-76"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT))</span>
+<span id="cb10-77"><a href="#cb10-77"></a></span>
+<span id="cb10-78"><a href="#cb10-78"></a><span class="fu">var_labels</span>(advs_f) <span class="ot">&lt;-</span> advs_label</span>
+<span id="cb10-79"><a href="#cb10-79"></a><span class="in">```</span></span>
+<span id="cb10-80"><a href="#cb10-80"></a></span>
+<span id="cb10-81"><a href="#cb10-81"></a><span class="fu">## Standard Table</span></span>
+<span id="cb10-82"><a href="#cb10-82"></a></span>
+<span id="cb10-83"><a href="#cb10-83"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb10-84"><a href="#cb10-84"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb10-85"><a href="#cb10-85"></a></span>
+<span id="cb10-86"><a href="#cb10-86"></a>afun <span class="ot">&lt;-</span> <span class="cf">function</span>(x, .var, .spl_context, ...) {</span>
+<span id="cb10-87"><a href="#cb10-87"></a>  n_fun <span class="ot">&lt;-</span> <span class="fu">sum</span>(<span class="sc">!</span><span class="fu">is.na</span>(x), <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-88"><a href="#cb10-88"></a>  <span class="cf">if</span> (n_fun <span class="sc">==</span> <span class="dv">0</span>) {</span>
+<span id="cb10-89"><a href="#cb10-89"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-90"><a href="#cb10-90"></a>    median_fun <span class="ot">&lt;-</span> <span class="cn">NA</span></span>
+<span id="cb10-91"><a href="#cb10-91"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="cn">NA</span>, <span class="cn">NA</span>)</span>
+<span id="cb10-92"><a href="#cb10-92"></a>  } <span class="cf">else</span> {</span>
+<span id="cb10-93"><a href="#cb10-93"></a>    mean_sd_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">mean</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>), <span class="fu">sd</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>))</span>
+<span id="cb10-94"><a href="#cb10-94"></a>    median_fun <span class="ot">&lt;-</span> <span class="fu">median</span>(x, <span class="at">na.rm =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb10-95"><a href="#cb10-95"></a>    min_max_fun <span class="ot">&lt;-</span> <span class="fu">c</span>(<span class="fu">min</span>(x), <span class="fu">max</span>(x))</span>
+<span id="cb10-96"><a href="#cb10-96"></a>  }</span>
+<span id="cb10-97"><a href="#cb10-97"></a>  is_chg <span class="ot">&lt;-</span> .var <span class="sc">==</span> <span class="st">"CHG"</span></span>
+<span id="cb10-98"><a href="#cb10-98"></a>  is_baseline <span class="ot">&lt;-</span> .spl_context<span class="sc">$</span>value[<span class="fu">which</span>(.spl_context<span class="sc">$</span>split <span class="sc">==</span> <span class="st">"AVISIT"</span>)] <span class="sc">==</span> <span class="st">"BASELINE"</span></span>
+<span id="cb10-99"><a href="#cb10-99"></a>  <span class="cf">if</span> (is_baseline <span class="sc">&amp;&amp;</span> is_chg) n_fun <span class="ot">&lt;-</span> mean_sd_fun <span class="ot">&lt;-</span> median_fun <span class="ot">&lt;-</span> min_max_fun <span class="ot">&lt;-</span> <span class="cn">NULL</span></span>
+<span id="cb10-100"><a href="#cb10-100"></a></span>
+<span id="cb10-101"><a href="#cb10-101"></a>  <span class="fu">in_rows</span>(</span>
+<span id="cb10-102"><a href="#cb10-102"></a>    <span class="st">"n"</span> <span class="ot">=</span> n_fun,</span>
+<span id="cb10-103"><a href="#cb10-103"></a>    <span class="st">"Mean (SD)"</span> <span class="ot">=</span> mean_sd_fun,</span>
+<span id="cb10-104"><a href="#cb10-104"></a>    <span class="st">"Median"</span> <span class="ot">=</span> median_fun,</span>
+<span id="cb10-105"><a href="#cb10-105"></a>    <span class="st">"Min - Max"</span> <span class="ot">=</span> min_max_fun,</span>
+<span id="cb10-106"><a href="#cb10-106"></a>    <span class="at">.formats =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"xx"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"xx.xx (xx.xx)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"xx.xx"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"xx.xx - xx.xx"</span>),</span>
+<span id="cb10-107"><a href="#cb10-107"></a>    <span class="at">.format_na_strs =</span> <span class="fu">list</span>(<span class="st">"n"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Mean (SD)"</span> <span class="ot">=</span> <span class="st">"NE (NE)"</span>, <span class="st">"Median"</span> <span class="ot">=</span> <span class="st">"NE"</span>, <span class="st">"Min - Max"</span> <span class="ot">=</span> <span class="st">"NE - NE"</span>)</span>
+<span id="cb10-108"><a href="#cb10-108"></a>  )</span>
+<span id="cb10-109"><a href="#cb10-109"></a>}</span>
+<span id="cb10-110"><a href="#cb10-110"></a></span>
+<span id="cb10-111"><a href="#cb10-111"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-112"><a href="#cb10-112"></a>  <span class="fu">split_cols_by</span>(<span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-113"><a href="#cb10-113"></a>  <span class="fu">split_rows_by</span>(<span class="st">"AVISIT"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="st">"</span><span class="sc">\n\n</span><span class="st">Analysis Visit"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-114"><a href="#cb10-114"></a>  <span class="fu">split_cols_by_multivar</span>(</span>
+<span id="cb10-115"><a href="#cb10-115"></a>    <span class="at">vars =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>),</span>
+<span id="cb10-116"><a href="#cb10-116"></a>    <span class="at">varlabels =</span> <span class="fu">c</span>(<span class="st">"Value at Visit"</span>, <span class="st">"Change from</span><span class="sc">\n</span><span class="st">Baseline"</span>)</span>
+<span id="cb10-117"><a href="#cb10-117"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb10-118"><a href="#cb10-118"></a>  <span class="fu">analyze_colvars</span>(<span class="at">afun =</span> afun)</span>
+<span id="cb10-119"><a href="#cb10-119"></a></span>
+<span id="cb10-120"><a href="#cb10-120"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb10-121"><a href="#cb10-121"></a>result</span>
+<span id="cb10-122"><a href="#cb10-122"></a><span class="in">```</span></span>
+<span id="cb10-123"><a href="#cb10-123"></a></span>
+<span id="cb10-124"><a href="#cb10-124"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb10-125"><a href="#cb10-125"></a></span>
+<span id="cb10-126"><a href="#cb10-126"></a><span class="fu">## `teal` App</span></span>
+<span id="cb10-127"><a href="#cb10-127"></a></span>
+<span id="cb10-128"><a href="#cb10-128"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb10-129"><a href="#cb10-129"></a><span class="co">#| screenshot.opts = list(delay = 30)</span></span>
+<span id="cb10-130"><a href="#cb10-130"></a></span>
+<span id="cb10-131"><a href="#cb10-131"></a><span class="fu">library</span>(scda)</span>
+<span id="cb10-132"><a href="#cb10-132"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb10-133"><a href="#cb10-133"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb10-134"><a href="#cb10-134"></a></span>
+<span id="cb10-135"><a href="#cb10-135"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb10-136"><a href="#cb10-136"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb10-137"><a href="#cb10-137"></a>advs_label <span class="ot">&lt;-</span> <span class="fu">var_labels</span>(advs)</span>
+<span id="cb10-138"><a href="#cb10-138"></a></span>
+<span id="cb10-139"><a href="#cb10-139"></a><span class="co"># post-baseline</span></span>
+<span id="cb10-140"><a href="#cb10-140"></a>advs_pb <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb10-141"><a href="#cb10-141"></a>  <span class="fu">filter</span>(</span>
+<span id="cb10-142"><a href="#cb10-142"></a>    ABLFL <span class="sc">!=</span> <span class="st">"Y"</span>,</span>
+<span id="cb10-143"><a href="#cb10-143"></a>    ABLFL2 <span class="sc">!=</span> <span class="st">"Y"</span></span>
+<span id="cb10-144"><a href="#cb10-144"></a>  )</span>
+<span id="cb10-145"><a href="#cb10-145"></a></span>
+<span id="cb10-146"><a href="#cb10-146"></a>advs_pb_max <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-147"><a href="#cb10-147"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-148"><a href="#cb10-148"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVAL)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-149"><a href="#cb10-149"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-150"><a href="#cb10-150"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-151"><a href="#cb10-151"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Maximum"</span>)</span>
+<span id="cb10-152"><a href="#cb10-152"></a></span>
+<span id="cb10-153"><a href="#cb10-153"></a>advs_pb_min <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-154"><a href="#cb10-154"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-155"><a href="#cb10-155"></a>  <span class="fu">arrange</span>(AVAL) <span class="sc">%&gt;%</span></span>
+<span id="cb10-156"><a href="#cb10-156"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-157"><a href="#cb10-157"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-158"><a href="#cb10-158"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Minimum"</span>)</span>
+<span id="cb10-159"><a href="#cb10-159"></a></span>
+<span id="cb10-160"><a href="#cb10-160"></a>advs_pb_last <span class="ot">&lt;-</span> advs_pb <span class="sc">%&gt;%</span></span>
+<span id="cb10-161"><a href="#cb10-161"></a>  <span class="fu">group_by</span>(PARAM, USUBJID) <span class="sc">%&gt;%</span></span>
+<span id="cb10-162"><a href="#cb10-162"></a>  <span class="fu">arrange</span>(<span class="fu">desc</span>(AVISITN)) <span class="sc">%&gt;%</span></span>
+<span id="cb10-163"><a href="#cb10-163"></a>  <span class="fu">slice</span>(<span class="dv">1</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb10-164"><a href="#cb10-164"></a>  <span class="fu">ungroup</span>() <span class="sc">%&gt;%</span></span>
+<span id="cb10-165"><a href="#cb10-165"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="st">"Post-Baseline Last"</span>)</span>
+<span id="cb10-166"><a href="#cb10-166"></a></span>
+<span id="cb10-167"><a href="#cb10-167"></a>advs_f <span class="ot">&lt;-</span> <span class="fu">rbind</span>(</span>
+<span id="cb10-168"><a href="#cb10-168"></a>  advs,</span>
+<span id="cb10-169"><a href="#cb10-169"></a>  advs_pb_last,</span>
+<span id="cb10-170"><a href="#cb10-170"></a>  advs_pb_min,</span>
+<span id="cb10-171"><a href="#cb10-171"></a>  advs_pb_max</span>
+<span id="cb10-172"><a href="#cb10-172"></a>)</span>
+<span id="cb10-173"><a href="#cb10-173"></a></span>
+<span id="cb10-174"><a href="#cb10-174"></a>advs_f <span class="ot">&lt;-</span> advs_f <span class="sc">%&gt;%</span></span>
+<span id="cb10-175"><a href="#cb10-175"></a>  <span class="fu">mutate</span>(<span class="at">AVISIT =</span> <span class="fu">droplevels</span>(AVISIT))</span>
+<span id="cb10-176"><a href="#cb10-176"></a></span>
+<span id="cb10-177"><a href="#cb10-177"></a><span class="fu">var_labels</span>(advs_f) <span class="ot">&lt;-</span> advs_label</span>
+<span id="cb10-178"><a href="#cb10-178"></a></span>
+<span id="cb10-179"><a href="#cb10-179"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb10-180"><a href="#cb10-180"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb10-181"><a href="#cb10-181"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>,</span>
+<span id="cb10-182"><a href="#cb10-182"></a>      adsl,</span>
+<span id="cb10-183"><a href="#cb10-183"></a>      <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span></span>
+<span id="cb10-184"><a href="#cb10-184"></a>    ),</span>
+<span id="cb10-185"><a href="#cb10-185"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADVS"</span>,</span>
+<span id="cb10-186"><a href="#cb10-186"></a>      advs_f,</span>
+<span id="cb10-187"><a href="#cb10-187"></a>      <span class="at">code =</span> <span class="st">'ADVS &lt;- synthetic_cdisc_dataset("latest", "advs")</span></span>
+<span id="cb10-188"><a href="#cb10-188"></a><span class="st">                  ADVS_label &lt;- var_labels(ADVS)</span></span>
+<span id="cb10-189"><a href="#cb10-189"></a></span>
+<span id="cb10-190"><a href="#cb10-190"></a><span class="st">                  # post-baseline</span></span>
+<span id="cb10-191"><a href="#cb10-191"></a><span class="st">                  ADVS_pb &lt;- ADVS %&gt;%</span></span>
+<span id="cb10-192"><a href="#cb10-192"></a><span class="st">                    filter(</span></span>
+<span id="cb10-193"><a href="#cb10-193"></a><span class="st">                      ABLFL != "Y",</span></span>
+<span id="cb10-194"><a href="#cb10-194"></a><span class="st">                      ABLFL2 != "Y"</span></span>
+<span id="cb10-195"><a href="#cb10-195"></a><span class="st">                    )</span></span>
+<span id="cb10-196"><a href="#cb10-196"></a></span>
+<span id="cb10-197"><a href="#cb10-197"></a><span class="st">                  ADVS_pb_max &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb10-198"><a href="#cb10-198"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb10-199"><a href="#cb10-199"></a><span class="st">                    arrange(desc(AVAL)) %&gt;%</span></span>
+<span id="cb10-200"><a href="#cb10-200"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb10-201"><a href="#cb10-201"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb10-202"><a href="#cb10-202"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Maximum")</span></span>
+<span id="cb10-203"><a href="#cb10-203"></a></span>
+<span id="cb10-204"><a href="#cb10-204"></a><span class="st">                  ADVS_pb_min &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb10-205"><a href="#cb10-205"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb10-206"><a href="#cb10-206"></a><span class="st">                    arrange(AVAL) %&gt;%</span></span>
+<span id="cb10-207"><a href="#cb10-207"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb10-208"><a href="#cb10-208"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb10-209"><a href="#cb10-209"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Minimum")</span></span>
+<span id="cb10-210"><a href="#cb10-210"></a></span>
+<span id="cb10-211"><a href="#cb10-211"></a><span class="st">                  ADVS_pb_last &lt;- ADVS_pb %&gt;%</span></span>
+<span id="cb10-212"><a href="#cb10-212"></a><span class="st">                    group_by(PARAM, USUBJID) %&gt;%</span></span>
+<span id="cb10-213"><a href="#cb10-213"></a><span class="st">                    arrange(desc(AVISITN)) %&gt;%</span></span>
+<span id="cb10-214"><a href="#cb10-214"></a><span class="st">                    slice(1) %&gt;%</span></span>
+<span id="cb10-215"><a href="#cb10-215"></a><span class="st">                    ungroup() %&gt;%</span></span>
+<span id="cb10-216"><a href="#cb10-216"></a><span class="st">                    mutate(AVISIT = "Post-Baseline Last")</span></span>
+<span id="cb10-217"><a href="#cb10-217"></a></span>
+<span id="cb10-218"><a href="#cb10-218"></a><span class="st">                  ADVS_f &lt;- rbind(</span></span>
+<span id="cb10-219"><a href="#cb10-219"></a><span class="st">                    ADVS,</span></span>
+<span id="cb10-220"><a href="#cb10-220"></a><span class="st">                    ADVS_pb_last,</span></span>
+<span id="cb10-221"><a href="#cb10-221"></a><span class="st">                    ADVS_pb_min,</span></span>
+<span id="cb10-222"><a href="#cb10-222"></a><span class="st">                    ADVS_pb_max</span></span>
+<span id="cb10-223"><a href="#cb10-223"></a><span class="st">                  )</span></span>
+<span id="cb10-224"><a href="#cb10-224"></a></span>
+<span id="cb10-225"><a href="#cb10-225"></a><span class="st">                  ADVS &lt;- ADVS_f %&gt;%</span></span>
+<span id="cb10-226"><a href="#cb10-226"></a><span class="st">                    mutate(AVISIT = droplevels(AVISIT))</span></span>
+<span id="cb10-227"><a href="#cb10-227"></a><span class="st">                  var_labels(ADVS) &lt;- ADVS_label'</span></span>
+<span id="cb10-228"><a href="#cb10-228"></a>    ),</span>
+<span id="cb10-229"><a href="#cb10-229"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-230"><a href="#cb10-230"></a>  ),</span>
+<span id="cb10-231"><a href="#cb10-231"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb10-232"><a href="#cb10-232"></a>    <span class="fu">tm_t_summary_by</span>(</span>
+<span id="cb10-233"><a href="#cb10-233"></a>      <span class="at">label =</span> <span class="st">"Vital Sign Results and Change from Baseline by Visit"</span>,</span>
+<span id="cb10-234"><a href="#cb10-234"></a>      <span class="at">dataname =</span> <span class="st">"ADVS"</span>,</span>
+<span id="cb10-235"><a href="#cb10-235"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-236"><a href="#cb10-236"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb10-237"><a href="#cb10-237"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb10-238"><a href="#cb10-238"></a>      ),</span>
+<span id="cb10-239"><a href="#cb10-239"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-240"><a href="#cb10-240"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="fu">c</span>(<span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb10-241"><a href="#cb10-241"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVISIT"</span>, <span class="st">"PARAM"</span>)</span>
+<span id="cb10-242"><a href="#cb10-242"></a>      ),</span>
+<span id="cb10-243"><a href="#cb10-243"></a>      <span class="at">summarize_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-244"><a href="#cb10-244"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)),</span>
+<span id="cb10-245"><a href="#cb10-245"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"AVAL"</span>, <span class="st">"CHG"</span>)</span>
+<span id="cb10-246"><a href="#cb10-246"></a>      ),</span>
+<span id="cb10-247"><a href="#cb10-247"></a>      <span class="at">useNA =</span> <span class="st">"ifany"</span>,</span>
+<span id="cb10-248"><a href="#cb10-248"></a>      <span class="at">paramcd =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb10-249"><a href="#cb10-249"></a>        <span class="at">choices =</span> <span class="fu">value_choices</span>(advs, <span class="st">"PARAMCD"</span>, <span class="st">"PARAM"</span>),</span>
+<span id="cb10-250"><a href="#cb10-250"></a>        <span class="at">selected =</span> <span class="st">"DIABP"</span></span>
+<span id="cb10-251"><a href="#cb10-251"></a>      ),</span>
+<span id="cb10-252"><a href="#cb10-252"></a>      <span class="at">parallel_vars =</span> <span class="cn">TRUE</span></span>
+<span id="cb10-253"><a href="#cb10-253"></a>    )</span>
+<span id="cb10-254"><a href="#cb10-254"></a>  ),</span>
+<span id="cb10-255"><a href="#cb10-255"></a>  <span class="at">filter =</span> <span class="fu">list</span>(<span class="at">ADVS =</span> <span class="fu">list</span>(<span class="at">AVAL =</span> <span class="fu">list</span>()))</span>
+<span id="cb10-256"><a href="#cb10-256"></a>)</span>
+<span id="cb10-257"><a href="#cb10-257"></a></span>
+<span id="cb10-258"><a href="#cb10-258"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb10-259"><a href="#cb10-259"></a><span class="in">```</span></span>
+<span id="cb10-260"><a href="#cb10-260"></a></span>
+<span id="cb10-261"><a href="#cb10-261"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb10-262"><a href="#cb10-262"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
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\ No newline at end of file
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+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="true">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="true" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 show">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    
+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><header id="title-block-header" class="quarto-title-block default"><div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">VST02</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+<p class="subtitle lead">Vital Sign Abnormalities</p>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header><hr>
+<div class="tabset-margin-container"></div><div class="panel-tabset">
+<ul class="nav nav-tabs" role="tablist">
+<li class="nav-item" role="presentation"><a class="nav-link active" id="tabset-1-1-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-1" role="tab" aria-controls="tabset-1-1" aria-selected="true" aria-current="page">Data Setup</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-2-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-2" role="tab" aria-controls="tabset-1-2" aria-selected="false">VST02_1 – Table of Abnormalities <br> Regardless of Abnormality at Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-3-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-3" role="tab" aria-controls="tabset-1-3" aria-selected="false">VST02_2 – Table of Abnormalities Among <br> Subjects Without Abnormality at Baseline</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-4-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-4" role="tab" aria-controls="tabset-1-4" aria-selected="false"><code>teal</code> App</a></li>
+<li class="nav-item" role="presentation"><a class="nav-link" id="tabset-1-5-tab" data-bs-toggle="tab" data-bs-target="#tabset-1-5" role="tab" aria-controls="tabset-1-5" aria-selected="false">Reproducibility</a></li>
+</ul>
+<div class="tab-content">
+<div id="tabset-1-1" class="tab-pane active" role="tabpanel" aria-labelledby="tabset-1-1-tab">
+<div class="cell" data-hash="vst02_cache/html/setup_e391487794c706c97e9dcce7ea13b373">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb1"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb1-1"><a href="#cb1-1"></a><span class="fu">library</span>(scda)</span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="fu">library</span>(tern)</span>
+<span id="cb1-4"><a href="#cb1-4"></a></span>
+<span id="cb1-5"><a href="#cb1-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb1-7"><a href="#cb1-7"></a></span>
+<span id="cb1-8"><a href="#cb1-8"></a><span class="co"># Ensure character variables are converted to factors and empty strings</span></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="co"># and NAs are explicit missing levels.</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb1-11"><a href="#cb1-11"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="co"># Note:  We keep only post-baseline for analysis.</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a>advs_f <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb1-15"><a href="#cb1-15"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>, ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>    <span class="at">PARAM =</span> <span class="st">"Assessment"</span>,</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality"</span></span>
+<span id="cb1-19"><a href="#cb1-19"></a>  )</span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a><span class="co"># If you want to control which parameters in the table have only `LOW` or only `HIGH` theoretical ranges defined,</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a><span class="co"># see `tern::h_map_for_count_abnormal` with method "range" or refer to the `EGT02` example.</span></span>
+<span id="cb1-23"><a href="#cb1-23"></a><span class="co"># For `VST02` we want to keep both directions for all parameters so we will not use `trim_levels_to_map` as the split function.</span></span>
+<span id="cb1-24"><a href="#cb1-24"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+</div>
+<div id="tabset-1-2" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-2-tab">
+<div class="cell" data-test="{&quot;result_v1&quot;:&quot;result&quot;}" data-hash="vst02_cache/html/variant1_8e8bb7fcc8fa4acca45e1f000fc44913">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb2"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb2-1"><a href="#cb2-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-2"><a href="#cb2-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-3"><a href="#cb2-3"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb2-4"><a href="#cb2-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(advs_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb2-5"><a href="#cb2-5"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb2-6"><a href="#cb2-6"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb2-7"><a href="#cb2-7"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb2-8"><a href="#cb2-8"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb2-9"><a href="#cb2-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb2-10"><a href="#cb2-10"></a>  <span class="fu">append_varlabels</span>(advs_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb2-11"><a href="#cb2-11"></a></span>
+<span id="cb2-12"><a href="#cb2-12"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb2-13"><a href="#cb2-13"></a></span>
+<span id="cb2-14"><a href="#cb2-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Assessment                    A: Drug X        B: Placebo      C: Combination     All Patients  
+  Abnormality                  (N=134)           (N=134)           (N=132)           (N=400)    
+————————————————————————————————————————————————————————————————————————————————————————————————
+Diastolic Blood Pressure                                                                        
+  Low                      66/134 (49.3%)    86/134 (64.2%)    78/132 (59.1%)    230/400 (57.5%)
+  High                     88/134 (65.7%)    70/134 (52.2%)    76/132 (57.6%)    234/400 (58.5%)
+Pulse Rate                                                                                      
+  Low                      58/134 (43.3%)    32/134 (23.9%)    48/132 (36.4%)    138/400 (34.5%)
+  High                     53/134 (39.6%)    49/134 (36.6%)    44/132 (33.3%)    146/400 (36.5%)
+Respiratory Rate                                                                                
+  Low                      97/134 (72.4%)    84/134 (62.7%)    98/132 (74.2%)    279/400 (69.8%)
+  High                     96/134 (71.6%)    98/134 (73.1%)    98/132 (74.2%)     292/400 (73%) 
+Systolic Blood Pressure                                                                         
+  Low                       71/134 (53%)     77/134 (57.5%)    73/132 (55.3%)    221/400 (55.2%)
+  High                     78/134 (58.2%)    74/134 (55.2%)    73/132 (55.3%)    225/400 (56.2%)
+Temperature                                                                                     
+  Low                      108/134 (80.6%)   110/134 (82.1%)   108/132 (81.8%)   326/400 (81.5%)
+  High                     112/134 (83.6%)   106/134 (79.1%)   107/132 (81.1%)   325/400 (81.2%)
+Weight                                                                                          
+  Low                      43/134 (32.1%)    39/134 (29.1%)    39/132 (29.5%)    121/400 (30.2%)
+  High                     46/134 (34.3%)    43/134 (32.1%)    44/132 (33.3%)    133/400 (33.2%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-3" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-3-tab">
+<div class="cell" data-test="{&quot;result_v2&quot;:&quot;result&quot;}" data-hash="vst02_cache/html/variant2_cc6fe453bf34fecd1aa6c6b882123225">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb4"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb4-1"><a href="#cb4-1"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-2"><a href="#cb4-2"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-3"><a href="#cb4-3"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb4-4"><a href="#cb4-4"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(advs_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb4-5"><a href="#cb4-5"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb4-6"><a href="#cb4-6"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb4-7"><a href="#cb4-7"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb4-8"><a href="#cb4-8"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb4-9"><a href="#cb4-9"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb4-10"><a href="#cb4-10"></a>  <span class="fu">append_varlabels</span>(advs_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb4-11"><a href="#cb4-11"></a></span>
+<span id="cb4-12"><a href="#cb4-12"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb4-13"><a href="#cb4-13"></a></span>
+<span id="cb4-14"><a href="#cb4-14"></a>result</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>Assessment                   A: Drug X        B: Placebo     C: Combination    All Patients  
+  Abnormality                 (N=134)          (N=134)          (N=132)           (N=400)    
+—————————————————————————————————————————————————————————————————————————————————————————————
+Diastolic Blood Pressure                                                                     
+  Low                       54/108 (50%)    76/116 (65.5%)   68/114 (59.6%)   198/338 (58.6%)
+  High                     74/114 (64.9%)   56/109 (51.4%)   62/106 (58.5%)   192/329 (58.4%)
+Pulse Rate                                                                                   
+  Low                      53/121 (43.8%)    30/125 (24%)    42/119 (35.3%)   125/365 (34.2%)
+  High                      48/123 (39%)    45/116 (38.8%)   39/120 (32.5%)   132/359 (36.8%)
+Respiratory Rate                                                                             
+  Low                       72/100 (72%)    72/110 (65.5%)   79/102 (77.5%)   223/312 (71.5%)
+  High                      77/107 (72%)    78/108 (72.2%)   79/109 (72.5%)   234/324 (72.2%)
+Systolic Blood Pressure                                                                      
+  Low                       62/117 (53%)    63/114 (55.3%)   57/103 (55.3%)   182/334 (54.5%)
+  High                     64/110 (58.2%)   67/120 (55.8%)   68/115 (59.1%)   199/345 (57.7%)
+Temperature                                                                                  
+  Low                      77/96 (80.2%)     78/94 (83%)     74/90 (82.2%)    229/280 (81.8%)
+  High                     78/93 (83.9%)    73/92 (79.3%)     81/100 (81%)    232/285 (81.4%)
+Weight                                                                                       
+  Low                      42/129 (32.6%)   37/125 (29.6%)   37/123 (30.1%)   116/377 (30.8%)
+  High                     41/126 (32.5%)   41/124 (33.1%)   42/121 (34.7%)   124/371 (33.4%)</code></pre>
+</div>
+</div>
+</div>
+<div id="tabset-1-4" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-4-tab">
+<div class="cell" data-opts.label="skip_if_testing" data-screenshot.opts="{&quot;delay&quot;:10}" data-hash="vst02_cache/html/teal_8db2e9db3310bade534614c74d2c9dbd">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb6"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb6-1"><a href="#cb6-1"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb6-2"><a href="#cb6-2"></a><span class="fu">library</span>(scda)</span>
+<span id="cb6-3"><a href="#cb6-3"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb6-4"><a href="#cb6-4"></a></span>
+<span id="cb6-5"><a href="#cb6-5"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb6-6"><a href="#cb6-6"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb6-7"><a href="#cb6-7"></a>  <span class="fu">mutate</span>(<span class="at">ONTRTFL =</span> <span class="fu">ifelse</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>), <span class="st">""</span>, <span class="st">"Y"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb6-8"><a href="#cb6-8"></a>  <span class="fu">var_relabel</span>(<span class="at">ONTRTFL =</span> <span class="st">"On Treatment Record Flag"</span>)</span>
+<span id="cb6-9"><a href="#cb6-9"></a></span>
+<span id="cb6-10"><a href="#cb6-10"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb6-11"><a href="#cb6-11"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb6-12"><a href="#cb6-12"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb6-13"><a href="#cb6-13"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADVS"</span>, advs, <span class="at">code =</span> <span class="st">'ADVS &lt;- synthetic_cdisc_dataset("latest", "advs") %&gt;%</span></span>
+<span id="cb6-14"><a href="#cb6-14"></a><span class="st">      mutate(ONTRTFL = ifelse(AVISIT %in% c("SCREENING", "BASELINE"), "", "Y")) %&gt;%</span></span>
+<span id="cb6-15"><a href="#cb6-15"></a><span class="st">      var_relabel(ONTRTFL = "On Treatment Record Flag")'</span>),</span>
+<span id="cb6-16"><a href="#cb6-16"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-17"><a href="#cb6-17"></a>  ),</span>
+<span id="cb6-18"><a href="#cb6-18"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb6-19"><a href="#cb6-19"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb6-20"><a href="#cb6-20"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb6-21"><a href="#cb6-21"></a>      <span class="at">dataname =</span> <span class="st">"ADVS"</span>,</span>
+<span id="cb6-22"><a href="#cb6-22"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-23"><a href="#cb6-23"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb6-24"><a href="#cb6-24"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb6-25"><a href="#cb6-25"></a>      ),</span>
+<span id="cb6-26"><a href="#cb6-26"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-27"><a href="#cb6-27"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"VSCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb6-28"><a href="#cb6-28"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb6-29"><a href="#cb6-29"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-30"><a href="#cb6-30"></a>      ),</span>
+<span id="cb6-31"><a href="#cb6-31"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb6-32"><a href="#cb6-32"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb6-33"><a href="#cb6-33"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb6-34"><a href="#cb6-34"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb6-35"><a href="#cb6-35"></a>      ),</span>
+<span id="cb6-36"><a href="#cb6-36"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb6-37"><a href="#cb6-37"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb6-38"><a href="#cb6-38"></a>    )</span>
+<span id="cb6-39"><a href="#cb6-39"></a>  )</span>
+<span id="cb6-40"><a href="#cb6-40"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>[INFO] 2023-09-25 11:07:21.4427 pid:8623 token:[] teal.modules.clinical Initializing tm_t_abnormality</code></pre>
+</div>
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb8"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb8-1"><a href="#cb8-1"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output-display">
+<p><img src="vst02_files/figure-html/teal-1.png" class="img-fluid" width="1440"></p>
+</div>
+</div>
+</div>
+<div id="tabset-1-5" class="tab-pane" role="tabpanel" aria-labelledby="tabset-1-5-tab">
+<section id="session-info" class="level3"><h3 class="anchored" data-anchor-id="session-info">Session Info</h3>
+<div class="cell" data-renv.ignore="true" data-hash="vst02_cache/html/sessioninfo_24e76d2f92098f956e0ca5b3d1e22ddb">
+<details open=""><summary>Code</summary><div class="sourceCode cell-code" id="cb9"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb9-1"><a href="#cb9-1"></a><span class="fu">sessionInfo</span>()</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details><div class="cell-output cell-output-stdout">
+<pre><code>R version 4.3.1 (2023-06-16)
+Platform: x86_64-pc-linux-gnu (64-bit)
+Running under: Ubuntu 22.04.3 LTS
+
+Matrix products: default
+BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
+LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
+
+locale:
+ [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
+ [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
+ [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
+ [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
+ [9] LC_ADDRESS=C               LC_TELEPHONE=C            
+[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
+
+time zone: Etc/UTC
+tzcode source: system (glibc)
+
+attached base packages:
+[1] stats     graphics  grDevices utils     datasets  methods   base     
+
+other attached packages:
+ [1] teal.modules.clinical_0.8.16 teal_0.14.0                 
+ [3] teal.transform_0.4.0         teal.slice_0.4.0            
+ [5] teal.data_0.3.0              shiny_1.7.5                 
+ [7] tern_0.9.0                   rtables_0.6.3               
+ [9] magrittr_2.0.3               formatters_0.5.2            
+[11] dplyr_1.1.3                  scda_0.1.6                  
+
+loaded via a namespace (and not attached):
+ [1] tidyselect_1.2.0      fastmap_1.1.1         TH.data_1.1-2        
+ [4] promises_1.2.1        shinyjs_2.1.0         digest_0.6.33        
+ [7] estimability_1.4.1    mime_0.12             tern.gee_0.1.0       
+[10] lifecycle_1.0.3       ellipsis_0.3.2        processx_3.8.2       
+[13] survival_3.5-7        compiler_4.3.1        rlang_1.1.1          
+[16] sass_0.4.7            tools_4.3.1           utf8_1.2.3           
+[19] yaml_2.3.7            knitr_1.44            htmlwidgets_1.6.2    
+[22] multcomp_1.4-25       withr_2.5.0           purrr_1.0.2          
+[25] shinyWidgets_0.8.0    geepack_1.3.9         grid_4.3.1           
+[28] fansi_1.0.4           teal.logger_0.1.3     xtable_1.8-4         
+[31] colorspace_2.1-0      ggplot2_3.4.3         emmeans_1.8.8        
+[34] scales_1.2.1          MASS_7.3-60           cli_3.6.1            
+[37] mvtnorm_1.2-3         rmarkdown_2.25        generics_0.1.3       
+[40] rstudioapi_0.15.0     cachem_1.0.8          splines_4.3.1        
+[43] assertthat_0.2.1      vctrs_0.6.3           webshot_0.5.5        
+[46] Matrix_1.6-1.1        sandwich_3.0-2        jsonlite_1.8.7       
+[49] callr_3.7.3           teal.widgets_0.4.0    testthat_3.1.10      
+[52] fontawesome_0.5.2     jquerylib_0.1.4       tidyr_1.3.0          
+[55] glue_1.6.2            ps_1.7.5              codetools_0.2-19     
+[58] gtable_0.3.4          later_1.3.1           shinycssloaders_1.0.0
+[61] munsell_0.5.0         tibble_3.2.1          logger_0.2.2         
+[64] pillar_1.9.0          htmltools_0.5.6       brio_1.1.3           
+[67] R6_2.5.1              Rdpack_2.5            evaluate_0.21        
+[70] lattice_0.21-8        rbibutils_2.2.15      backports_1.4.1      
+[73] memoise_2.0.1         broom_1.0.5           teal.reporter_0.2.1  
+[76] httpuv_1.6.11         bslib_0.5.1           Rcpp_1.0.11          
+[79] coda_0.19-4           nlme_3.1-163          checkmate_2.2.0      
+[82] xfun_0.40             zoo_1.8-12            forcats_1.0.0        
+[85] pkgconfig_2.0.3      </code></pre>
+</div>
+</div>
+</section><section id="lock-file" class="level3"><h3 class="anchored" data-anchor-id="lock-file">
+<code>.lock</code> file</h3>
+<p>Download the <code>.lock</code> file and use <a href="https://rstudio.github.io/renv/reference/restore.html"><code>renv::restore()</code></a> on it to recreate environment used to generate this website.</p>
+<div class="cell" data-opts.label="skip_if_testing" data-renv.ignore="true" data-hash="vst02_cache/html/snapshot_3ee9a0dec1d4ced20ce3f6731ff0aff5">
+<details><summary>Code</summary><div class="sourceCode cell-code" id="cb11"><pre class="sourceCode numberSource r number-lines code-with-copy"><code class="sourceCode r"><span id="cb11-1"><a href="#cb11-1"></a>parent_file_path <span class="ot">&lt;-</span> knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-2"><a href="#cb11-2"></a></span>
+<span id="cb11-3"><a href="#cb11-3"></a>book_root_dir <span class="ot">&lt;-</span> parent_file_path</span>
+<span id="cb11-4"><a href="#cb11-4"></a><span class="cf">while</span> (<span class="sc">!</span><span class="fu">file.exists</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">"_quarto.yml"</span>))) book_root_dir <span class="ot">&lt;-</span> <span class="fu">dirname</span>(book_root_dir)</span>
+<span id="cb11-5"><a href="#cb11-5"></a></span>
+<span id="cb11-6"><a href="#cb11-6"></a>lock_path <span class="ot">&lt;-</span> <span class="fu">file.path</span>(<span class="st">"../../assets/www/lock"</span>, <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="fu">file.path</span>(book_root_dir, <span class="st">""</span>), <span class="st">""</span>, <span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>(<span class="at">dir =</span> <span class="cn">TRUE</span>))), <span class="st">".lock"</span>))</span>
+<span id="cb11-7"><a href="#cb11-7"></a></span>
+<span id="cb11-8"><a href="#cb11-8"></a>withr<span class="sc">::</span><span class="fu">with_options</span>(</span>
+<span id="cb11-9"><a href="#cb11-9"></a>  <span class="fu">list</span>(<span class="at">renv.verbose =</span> <span class="cn">FALSE</span>),</span>
+<span id="cb11-10"><a href="#cb11-10"></a>  renv<span class="sc">::</span><span class="fu">snapshot</span>(parent_file_path, <span class="at">lockfile =</span> lock_path, <span class="at">prompt =</span> <span class="cn">FALSE</span>, <span class="at">force =</span> <span class="cn">TRUE</span>)</span>
+<span id="cb11-11"><a href="#cb11-11"></a>)</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</details>
+</div>
+<p><a href="../../assets/www/lock/tables/vital-signs/vst02.lock">Download</a></p>
+</section>
+</div>
+</div>
+</div>
+
+
+<!-- -->
+
+
+</main><!-- /main --><script id="quarto-html-after-body" type="application/javascript">
+window.document.addEventListener("DOMContentLoaded", function (event) {
+  const toggleBodyColorMode = (bsSheetEl) => {
+    const mode = bsSheetEl.getAttribute("data-mode");
+    const bodyEl = window.document.querySelector("body");
+    if (mode === "dark") {
+      bodyEl.classList.add("quarto-dark");
+      bodyEl.classList.remove("quarto-light");
+    } else {
+      bodyEl.classList.add("quarto-light");
+      bodyEl.classList.remove("quarto-dark");
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+  const toggleBodyColorPrimary = () => {
+    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
+    if (bsSheetEl) {
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+    for (let i=0; i < stylesheets.length; i++) {
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+    for (let i=0; i < stylesheets.length; i++) {
+      const stylesheet = stylesheets[i];
+      stylesheet.rel = 'stylesheet';
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+  const manageTransitions = (selector, allowTransitions) => {
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+      } else {
+        el.classList.add('notransition');
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+</nav><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb12" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb12-1"><a href="#cb12-1"></a><span class="co">---</span></span>
+<span id="cb12-2"><a href="#cb12-2"></a><span class="an">title:</span><span class="co"> VST02</span></span>
+<span id="cb12-3"><a href="#cb12-3"></a><span class="an">subtitle:</span><span class="co"> Vital Sign Abnormalities</span></span>
+<span id="cb12-4"><a href="#cb12-4"></a><span class="co">---</span></span>
+<span id="cb12-5"><a href="#cb12-5"></a></span>
+<span id="cb12-6"><a href="#cb12-6"></a>------------------------------------------------------------------------</span>
+<span id="cb12-7"><a href="#cb12-7"></a></span>
+<span id="cb12-8"><a href="#cb12-8"></a>{{&lt; include ../../test-utils/envir_hook.qmd &gt;}}</span>
+<span id="cb12-9"><a href="#cb12-9"></a></span>
+<span id="cb12-10"><a href="#cb12-10"></a>::: panel-tabset</span>
+<span id="cb12-11"><a href="#cb12-11"></a><span class="fu">## Data Setup</span></span>
+<span id="cb12-12"><a href="#cb12-12"></a></span>
+<span id="cb12-13"><a href="#cb12-13"></a><span class="in">```{r setup, message=FALSE}</span></span>
+<span id="cb12-14"><a href="#cb12-14"></a><span class="co">#| code-fold: show</span></span>
+<span id="cb12-15"><a href="#cb12-15"></a></span>
+<span id="cb12-16"><a href="#cb12-16"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-17"><a href="#cb12-17"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-18"><a href="#cb12-18"></a><span class="fu">library</span>(tern)</span>
+<span id="cb12-19"><a href="#cb12-19"></a></span>
+<span id="cb12-20"><a href="#cb12-20"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-21"><a href="#cb12-21"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>)</span>
+<span id="cb12-22"><a href="#cb12-22"></a></span>
+<span id="cb12-23"><a href="#cb12-23"></a><span class="co"># Ensure character variables are converted to factors and empty strings</span></span>
+<span id="cb12-24"><a href="#cb12-24"></a><span class="co"># and NAs are explicit missing levels.</span></span>
+<span id="cb12-25"><a href="#cb12-25"></a>adsl <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(adsl)</span>
+<span id="cb12-26"><a href="#cb12-26"></a>advs <span class="ot">&lt;-</span> <span class="fu">df_explicit_na</span>(advs)</span>
+<span id="cb12-27"><a href="#cb12-27"></a></span>
+<span id="cb12-28"><a href="#cb12-28"></a><span class="co"># Note:  We keep only post-baseline for analysis.</span></span>
+<span id="cb12-29"><a href="#cb12-29"></a>advs_f <span class="ot">&lt;-</span> advs <span class="sc">%&gt;%</span></span>
+<span id="cb12-30"><a href="#cb12-30"></a>  <span class="fu">filter</span>(ONTRTFL <span class="sc">==</span> <span class="st">"Y"</span>, ANRIND <span class="sc">!=</span> <span class="st">"&lt;Missing&gt;"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-31"><a href="#cb12-31"></a>  <span class="fu">var_relabel</span>(</span>
+<span id="cb12-32"><a href="#cb12-32"></a>    <span class="at">PARAM =</span> <span class="st">"Assessment"</span>,</span>
+<span id="cb12-33"><a href="#cb12-33"></a>    <span class="at">ANRIND =</span> <span class="st">"Abnormality"</span></span>
+<span id="cb12-34"><a href="#cb12-34"></a>  )</span>
+<span id="cb12-35"><a href="#cb12-35"></a></span>
+<span id="cb12-36"><a href="#cb12-36"></a><span class="co"># If you want to control which parameters in the table have only `LOW` or only `HIGH` theoretical ranges defined,</span></span>
+<span id="cb12-37"><a href="#cb12-37"></a><span class="co"># see `tern::h_map_for_count_abnormal` with method "range" or refer to the `EGT02` example.</span></span>
+<span id="cb12-38"><a href="#cb12-38"></a><span class="co"># For `VST02` we want to keep both directions for all parameters so we will not use `trim_levels_to_map` as the split function.</span></span>
+<span id="cb12-39"><a href="#cb12-39"></a>split_fun <span class="ot">&lt;-</span> drop_split_levels</span>
+<span id="cb12-40"><a href="#cb12-40"></a><span class="in">```</span></span>
+<span id="cb12-41"><a href="#cb12-41"></a></span>
+<span id="cb12-42"><a href="#cb12-42"></a><span class="fu">## VST02_1 -- Table of Abnormalities &lt;br/&gt; Regardless of Abnormality at Baseline</span></span>
+<span id="cb12-43"><a href="#cb12-43"></a></span>
+<span id="cb12-44"><a href="#cb12-44"></a><span class="in">```{r variant1, test = list(result_v1 = "result")}</span></span>
+<span id="cb12-45"><a href="#cb12-45"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-46"><a href="#cb12-46"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-47"><a href="#cb12-47"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-48"><a href="#cb12-48"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(advs_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-49"><a href="#cb12-49"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb12-50"><a href="#cb12-50"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-51"><a href="#cb12-51"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb12-52"><a href="#cb12-52"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-53"><a href="#cb12-53"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-54"><a href="#cb12-54"></a>  <span class="fu">append_varlabels</span>(advs_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-55"><a href="#cb12-55"></a></span>
+<span id="cb12-56"><a href="#cb12-56"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-57"><a href="#cb12-57"></a></span>
+<span id="cb12-58"><a href="#cb12-58"></a>result</span>
+<span id="cb12-59"><a href="#cb12-59"></a><span class="in">```</span></span>
+<span id="cb12-60"><a href="#cb12-60"></a></span>
+<span id="cb12-61"><a href="#cb12-61"></a><span class="fu">## VST02_2 -- Table of Abnormalities Among &lt;br/&gt; Subjects Without Abnormality at Baseline</span></span>
+<span id="cb12-62"><a href="#cb12-62"></a></span>
+<span id="cb12-63"><a href="#cb12-63"></a><span class="in">```{r variant2, test = list(result_v2 = "result")}</span></span>
+<span id="cb12-64"><a href="#cb12-64"></a>lyt <span class="ot">&lt;-</span> <span class="fu">basic_table</span>(<span class="at">show_colcounts =</span> <span class="cn">TRUE</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-65"><a href="#cb12-65"></a>  <span class="fu">split_cols_by</span>(<span class="at">var =</span> <span class="st">"ACTARM"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-66"><a href="#cb12-66"></a>  <span class="fu">add_overall_col</span>(<span class="st">"All Patients"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-67"><a href="#cb12-67"></a>  <span class="fu">split_rows_by</span>(<span class="st">"PARAM"</span>, <span class="at">split_fun =</span> split_fun, <span class="at">label_pos =</span> <span class="st">"topleft"</span>, <span class="at">split_label =</span> <span class="fu">obj_label</span>(advs_f<span class="sc">$</span>PARAM)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-68"><a href="#cb12-68"></a>  <span class="fu">count_abnormal</span>(</span>
+<span id="cb12-69"><a href="#cb12-69"></a>    <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-70"><a href="#cb12-70"></a>    <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb12-71"><a href="#cb12-71"></a>    <span class="at">exclude_base_abn =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-72"><a href="#cb12-72"></a>  ) <span class="sc">%&gt;%</span></span>
+<span id="cb12-73"><a href="#cb12-73"></a>  <span class="fu">append_varlabels</span>(advs_f, <span class="st">"ANRIND"</span>, <span class="at">indent =</span> 1L)</span>
+<span id="cb12-74"><a href="#cb12-74"></a></span>
+<span id="cb12-75"><a href="#cb12-75"></a>result <span class="ot">&lt;-</span> <span class="fu">build_table</span>(<span class="at">lyt =</span> lyt, <span class="at">df =</span> advs_f, <span class="at">alt_counts_df =</span> adsl)</span>
+<span id="cb12-76"><a href="#cb12-76"></a></span>
+<span id="cb12-77"><a href="#cb12-77"></a>result</span>
+<span id="cb12-78"><a href="#cb12-78"></a><span class="in">```</span></span>
+<span id="cb12-79"><a href="#cb12-79"></a></span>
+<span id="cb12-80"><a href="#cb12-80"></a>{{&lt; include ../../test-utils/save_results.qmd &gt;}}</span>
+<span id="cb12-81"><a href="#cb12-81"></a></span>
+<span id="cb12-82"><a href="#cb12-82"></a><span class="fu">## `teal` App</span></span>
+<span id="cb12-83"><a href="#cb12-83"></a></span>
+<span id="cb12-84"><a href="#cb12-84"></a><span class="in">```{r teal, message=FALSE, opts.label='skip_if_testing'}</span></span>
+<span id="cb12-85"><a href="#cb12-85"></a><span class="co">#| screenshot.opts = list(delay = 10)</span></span>
+<span id="cb12-86"><a href="#cb12-86"></a></span>
+<span id="cb12-87"><a href="#cb12-87"></a><span class="fu">library</span>(teal.modules.clinical)</span>
+<span id="cb12-88"><a href="#cb12-88"></a><span class="fu">library</span>(scda)</span>
+<span id="cb12-89"><a href="#cb12-89"></a><span class="fu">library</span>(dplyr)</span>
+<span id="cb12-90"><a href="#cb12-90"></a></span>
+<span id="cb12-91"><a href="#cb12-91"></a>adsl <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"adsl"</span>)</span>
+<span id="cb12-92"><a href="#cb12-92"></a>advs <span class="ot">&lt;-</span> <span class="fu">synthetic_cdisc_dataset</span>(<span class="st">"latest"</span>, <span class="st">"advs"</span>) <span class="sc">%&gt;%</span></span>
+<span id="cb12-93"><a href="#cb12-93"></a>  <span class="fu">mutate</span>(<span class="at">ONTRTFL =</span> <span class="fu">ifelse</span>(AVISIT <span class="sc">%in%</span> <span class="fu">c</span>(<span class="st">"SCREENING"</span>, <span class="st">"BASELINE"</span>), <span class="st">""</span>, <span class="st">"Y"</span>)) <span class="sc">%&gt;%</span></span>
+<span id="cb12-94"><a href="#cb12-94"></a>  <span class="fu">var_relabel</span>(<span class="at">ONTRTFL =</span> <span class="st">"On Treatment Record Flag"</span>)</span>
+<span id="cb12-95"><a href="#cb12-95"></a></span>
+<span id="cb12-96"><a href="#cb12-96"></a>app <span class="ot">&lt;-</span> <span class="fu">init</span>(</span>
+<span id="cb12-97"><a href="#cb12-97"></a>  <span class="at">data =</span> <span class="fu">cdisc_data</span>(</span>
+<span id="cb12-98"><a href="#cb12-98"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADSL"</span>, adsl, <span class="at">code =</span> <span class="st">'ADSL &lt;- synthetic_cdisc_dataset("latest", "adsl")'</span>),</span>
+<span id="cb12-99"><a href="#cb12-99"></a>    <span class="fu">cdisc_dataset</span>(<span class="st">"ADVS"</span>, advs, <span class="at">code =</span> <span class="st">'ADVS &lt;- synthetic_cdisc_dataset("latest", "advs") %&gt;%</span></span>
+<span id="cb12-100"><a href="#cb12-100"></a><span class="st">      mutate(ONTRTFL = ifelse(AVISIT %in% c("SCREENING", "BASELINE"), "", "Y")) %&gt;%</span></span>
+<span id="cb12-101"><a href="#cb12-101"></a><span class="st">      var_relabel(ONTRTFL = "On Treatment Record Flag")'</span>),</span>
+<span id="cb12-102"><a href="#cb12-102"></a>    <span class="at">check =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-103"><a href="#cb12-103"></a>  ),</span>
+<span id="cb12-104"><a href="#cb12-104"></a>  <span class="at">modules =</span> <span class="fu">modules</span>(</span>
+<span id="cb12-105"><a href="#cb12-105"></a>    <span class="fu">tm_t_abnormality</span>(</span>
+<span id="cb12-106"><a href="#cb12-106"></a>      <span class="at">label =</span> <span class="st">"Abnormality Table"</span>,</span>
+<span id="cb12-107"><a href="#cb12-107"></a>      <span class="at">dataname =</span> <span class="st">"ADVS"</span>,</span>
+<span id="cb12-108"><a href="#cb12-108"></a>      <span class="at">arm_var =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-109"><a href="#cb12-109"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(adsl, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"ARM"</span>, <span class="st">"ARMCD"</span>)),</span>
+<span id="cb12-110"><a href="#cb12-110"></a>        <span class="at">selected =</span> <span class="st">"ARM"</span></span>
+<span id="cb12-111"><a href="#cb12-111"></a>      ),</span>
+<span id="cb12-112"><a href="#cb12-112"></a>      <span class="at">by_vars =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-113"><a href="#cb12-113"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="at">subset =</span> <span class="fu">c</span>(<span class="st">"VSCAT"</span>, <span class="st">"PARAM"</span>, <span class="st">"AVISIT"</span>)),</span>
+<span id="cb12-114"><a href="#cb12-114"></a>        <span class="at">selected =</span> <span class="fu">c</span>(<span class="st">"PARAM"</span>),</span>
+<span id="cb12-115"><a href="#cb12-115"></a>        <span class="at">keep_order =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-116"><a href="#cb12-116"></a>      ),</span>
+<span id="cb12-117"><a href="#cb12-117"></a>      <span class="at">grade =</span> <span class="fu">choices_selected</span>(</span>
+<span id="cb12-118"><a href="#cb12-118"></a>        <span class="at">choices =</span> <span class="fu">variable_choices</span>(advs, <span class="at">subset =</span> <span class="st">"ANRIND"</span>),</span>
+<span id="cb12-119"><a href="#cb12-119"></a>        <span class="at">selected =</span> <span class="st">"ANRIND"</span>,</span>
+<span id="cb12-120"><a href="#cb12-120"></a>        <span class="at">fixed =</span> <span class="cn">TRUE</span></span>
+<span id="cb12-121"><a href="#cb12-121"></a>      ),</span>
+<span id="cb12-122"><a href="#cb12-122"></a>      <span class="at">abnormal =</span> <span class="fu">list</span>(<span class="at">Low =</span> <span class="fu">c</span>(<span class="st">"LOW"</span>, <span class="st">"LOW LOW"</span>), <span class="at">High =</span> <span class="fu">c</span>(<span class="st">"HIGH"</span>, <span class="st">"HIGH HIGH"</span>)),</span>
+<span id="cb12-123"><a href="#cb12-123"></a>      <span class="at">exclude_base_abn =</span> <span class="cn">FALSE</span></span>
+<span id="cb12-124"><a href="#cb12-124"></a>    )</span>
+<span id="cb12-125"><a href="#cb12-125"></a>  )</span>
+<span id="cb12-126"><a href="#cb12-126"></a>)</span>
+<span id="cb12-127"><a href="#cb12-127"></a></span>
+<span id="cb12-128"><a href="#cb12-128"></a><span class="fu">shinyApp</span>(app<span class="sc">$</span>ui, app<span class="sc">$</span>server)</span>
+<span id="cb12-129"><a href="#cb12-129"></a><span class="in">```</span></span>
+<span id="cb12-130"><a href="#cb12-130"></a></span>
+<span id="cb12-131"><a href="#cb12-131"></a>{{&lt; include ../../repro.qmd &gt;}}</span>
+<span id="cb12-132"><a href="#cb12-132"></a>:::</span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
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new file mode 100644
index 0000000000..c6e90e1d1d
--- /dev/null
+++ b/stable/test-utils/envir_hook.html
@@ -0,0 +1,1856 @@
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+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog – envir_hook</title>
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+<script src="../site_libs/quarto-nav/quarto-nav.js"></script>
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+    <a class="navbar-brand" href="../index.html">
+    <span class="navbar-title">TLG Catalog</span>
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+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
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+<li>
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+ <span class="dropdown-text">Development</span></a>
+  </li>  
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+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
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+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+<!-- sidebar -->
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+      <a href="../index.html" class="sidebar-logo-link">
+      <img src="../assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none"></a>
+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
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+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
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+ <span class="menu-text">ADAT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
+</nav><div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
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+<!-- main -->
+<main class="content column-page-right" id="quarto-document-content"><div class="quarto-title-block"><div class="quarto-title-tools-only"><h1></h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+
+<!-- -->
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+      disableStylesheet(alternateStylesheets);
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+    manageTransitions('#quarto-margin-sidebar .nav-link', true);
+    // Switch the toggles
+    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
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+          toggle.classList.remove("alternate");
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+    // properly recolor the scrollbar when toggling (#1455)
+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
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+  const setStyleSentinel = (alternate) => {
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+      window.localStorage.setItem("quarto-color-scheme", value);
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+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
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+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
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+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
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+      if (clz.startsWith('code-annotation-')) {                     
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+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
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+    // don't keep focus
+    button.blur();
+    // flash "checked"
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+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
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+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
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+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
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+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb1" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb1-1"><a href="#cb1-1"></a><span class="in">```{r knitr_utils, include=FALSE}</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="co">#| renv.ignore: TRUE</span></span>
+<span id="cb1-3"><a href="#cb1-3"></a></span>
+<span id="cb1-4"><a href="#cb1-4"></a>knitr<span class="sc">::</span>knit_hooks<span class="sc">$</span><span class="fu">set</span>(<span class="at">test =</span> <span class="cf">function</span>(options, envir, <span class="at">before =</span> <span class="cn">FALSE</span>) {</span>
+<span id="cb1-5"><a href="#cb1-5"></a>  <span class="cf">if</span> (<span class="fu">isFALSE</span>(before)) {</span>
+<span id="cb1-6"><a href="#cb1-6"></a>    <span class="cf">if</span> (<span class="sc">!</span><span class="fu">exists</span>(<span class="st">"tenv"</span>, <span class="at">envir =</span> envir)) {</span>
+<span id="cb1-7"><a href="#cb1-7"></a>      envir<span class="sc">$</span>tenv <span class="ot">&lt;-</span> <span class="fu">new.env</span>()</span>
+<span id="cb1-8"><a href="#cb1-8"></a>    }</span>
+<span id="cb1-9"><a href="#cb1-9"></a>    <span class="cf">for</span> (i <span class="cf">in</span> <span class="fu">seq_along</span>(options<span class="sc">$</span>test)) {</span>
+<span id="cb1-10"><a href="#cb1-10"></a>      expr <span class="ot">&lt;-</span> <span class="fu">substitute</span>(tenv<span class="sc">$</span>id <span class="ot">&lt;-</span> var, <span class="fu">list</span>(<span class="at">id =</span> <span class="fu">names</span>(options<span class="sc">$</span>test)[i], <span class="at">var =</span> <span class="fu">as.name</span>(options<span class="sc">$</span>test[[i]])))</span>
+<span id="cb1-11"><a href="#cb1-11"></a>      <span class="fu">eval</span>(expr, <span class="at">envir =</span> envir)</span>
+<span id="cb1-12"><a href="#cb1-12"></a>    }</span>
+<span id="cb1-13"><a href="#cb1-13"></a>  }</span>
+<span id="cb1-14"><a href="#cb1-14"></a>})</span>
+<span id="cb1-15"><a href="#cb1-15"></a></span>
+<span id="cb1-16"><a href="#cb1-16"></a>knitr<span class="sc">::</span>opts_template<span class="sc">$</span><span class="fu">set</span>(</span>
+<span id="cb1-17"><a href="#cb1-17"></a>  <span class="at">include_if_testing =</span> <span class="fu">list</span>(</span>
+<span id="cb1-18"><a href="#cb1-18"></a>    <span class="at">eval =</span> <span class="fu">isTRUE</span>(testthat<span class="sc">::</span><span class="fu">is_checking</span>() <span class="sc">||</span> testthat<span class="sc">::</span><span class="fu">is_testing</span>()),</span>
+<span id="cb1-19"><a href="#cb1-19"></a>    <span class="at">cache =</span> <span class="cn">FALSE</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a>  ),</span>
+<span id="cb1-21"><a href="#cb1-21"></a>  <span class="at">skip_if_testing =</span> <span class="fu">list</span>(</span>
+<span id="cb1-22"><a href="#cb1-22"></a>    <span class="at">eval =</span> <span class="fu">isFALSE</span>(testthat<span class="sc">::</span><span class="fu">is_checking</span>() <span class="sc">||</span> testthat<span class="sc">::</span><span class="fu">is_testing</span>())</span>
+<span id="cb1-23"><a href="#cb1-23"></a>  )</span>
+<span id="cb1-24"><a href="#cb1-24"></a>)</span>
+<span id="cb1-25"><a href="#cb1-25"></a><span class="in">```</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
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+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/test-utils/save_results.html b/stable/test-utils/save_results.html
new file mode 100644
index 0000000000..3b6bd4db17
--- /dev/null
+++ b/stable/test-utils/save_results.html
@@ -0,0 +1,1841 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+<title>TLG Catalog – save_results</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
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+ <span class="menu-text"></span></a>
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+      </div> <!-- /container-fluid -->
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+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
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+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
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+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
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+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
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+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
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+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
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+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">
+<li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="../tlg-index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+</div>
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+    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
+      manageTransitions("body", false);
+      window.scrollTo(0, 1);
+      setTimeout(() => {
+        window.scrollTo(0, 0);
+        manageTransitions("body", true);
+      }, 40);  
+    }
+  }
+  const isFileUrl = () => { 
+    return window.location.protocol === 'file:';
+  }
+  const hasAlternateSentinel = () => {  
+    let styleSentinel = getColorSchemeSentinel();
+    if (styleSentinel !== null) {
+      return styleSentinel === "alternate";
+    } else {
+      return false;
+    }
+  }
+  const setStyleSentinel = (alternate) => {
+    const value = alternate ? "alternate" : "default";
+    if (!isFileUrl()) {
+      window.localStorage.setItem("quarto-color-scheme", value);
+    } else {
+      localAlternateSentinel = value;
+    }
+  }
+  const getColorSchemeSentinel = () => {
+    if (!isFileUrl()) {
+      const storageValue = window.localStorage.getItem("quarto-color-scheme");
+      return storageValue != null ? storageValue : localAlternateSentinel;
+    } else {
+      return localAlternateSentinel;
+    }
+  }
+  let localAlternateSentinel = 'default';
+  // Dark / light mode switch
+  window.quartoToggleColorScheme = () => {
+    // Read the current dark / light value 
+    let toAlternate = !hasAlternateSentinel();
+    toggleColorMode(toAlternate);
+    setStyleSentinel(toAlternate);
+  };
+  // Ensure there is a toggle, if there isn't float one in the top right
+  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
+    const a = window.document.createElement('a');
+    a.classList.add('top-right');
+    a.classList.add('quarto-color-scheme-toggle');
+    a.href = "";
+    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
+    const i = window.document.createElement("i");
+    i.classList.add('bi');
+    a.appendChild(i);
+    window.document.body.appendChild(a);
+  }
+  // Switch to dark mode if need be
+  if (hasAlternateSentinel()) {
+    toggleColorMode(true);
+  } else {
+    toggleColorMode(false);
+  }
+  const icon = "";
+  const anchorJS = new window.AnchorJS();
+  anchorJS.options = {
+    placement: 'right',
+    icon: icon
+  };
+  anchorJS.add('.anchored');
+  const isCodeAnnotation = (el) => {
+    for (const clz of el.classList) {
+      if (clz.startsWith('code-annotation-')) {                     
+        return true;
+      }
+    }
+    return false;
+  }
+  const clipboard = new window.ClipboardJS('.code-copy-button', {
+    text: function(trigger) {
+      const codeEl = trigger.previousElementSibling.cloneNode(true);
+      for (const childEl of codeEl.children) {
+        if (isCodeAnnotation(childEl)) {
+          childEl.remove();
+        }
+      }
+      return codeEl.innerText;
+    }
+  });
+  clipboard.on('success', function(e) {
+    // button target
+    const button = e.trigger;
+    // don't keep focus
+    button.blur();
+    // flash "checked"
+    button.classList.add('code-copy-button-checked');
+    var currentTitle = button.getAttribute("title");
+    button.setAttribute("title", "Copied!");
+    let tooltip;
+    if (window.bootstrap) {
+      button.setAttribute("data-bs-toggle", "tooltip");
+      button.setAttribute("data-bs-placement", "left");
+      button.setAttribute("data-bs-title", "Copied!");
+      tooltip = new bootstrap.Tooltip(button, 
+        { trigger: "manual", 
+          customClass: "code-copy-button-tooltip",
+          offset: [0, -8]});
+      tooltip.show();    
+    }
+    setTimeout(function() {
+      if (tooltip) {
+        tooltip.hide();
+        button.removeAttribute("data-bs-title");
+        button.removeAttribute("data-bs-toggle");
+        button.removeAttribute("data-bs-placement");
+      }
+      button.setAttribute("title", currentTitle);
+      button.classList.remove('code-copy-button-checked');
+    }, 1000);
+    // clear code selection
+    e.clearSelection();
+  });
+  const viewSource = window.document.getElementById('quarto-view-source') ||
+                     window.document.getElementById('quarto-code-tools-source');
+  if (viewSource) {
+    const sourceUrl = viewSource.getAttribute("data-quarto-source-url");
+    viewSource.addEventListener("click", function(e) {
+      if (sourceUrl) {
+        // rstudio viewer pane
+        if (/\bcapabilities=\b/.test(window.location)) {
+          window.open(sourceUrl);
+        } else {
+          window.location.href = sourceUrl;
+        }
+      } else {
+        const modal = new bootstrap.Modal(document.getElementById('quarto-embedded-source-code-modal'));
+        modal.show();
+      }
+      return false;
+    });
+  }
+  function toggleCodeHandler(show) {
+    return function(e) {
+      const detailsSrc = window.document.querySelectorAll(".cell > details > .sourceCode");
+      for (let i=0; i<detailsSrc.length; i++) {
+        const details = detailsSrc[i].parentElement;
+        if (show) {
+          details.open = true;
+        } else {
+          details.removeAttribute("open");
+        }
+      }
+      const cellCodeDivs = window.document.querySelectorAll(".cell > .sourceCode");
+      const fromCls = show ? "hidden" : "unhidden";
+      const toCls = show ? "unhidden" : "hidden";
+      for (let i=0; i<cellCodeDivs.length; i++) {
+        const codeDiv = cellCodeDivs[i];
+        if (codeDiv.classList.contains(fromCls)) {
+          codeDiv.classList.remove(fromCls);
+          codeDiv.classList.add(toCls);
+        } 
+      }
+      return false;
+    }
+  }
+  const hideAllCode = window.document.getElementById("quarto-hide-all-code");
+  if (hideAllCode) {
+    hideAllCode.addEventListener("click", toggleCodeHandler(false));
+  }
+  const showAllCode = window.document.getElementById("quarto-show-all-code");
+  if (showAllCode) {
+    showAllCode.addEventListener("click", toggleCodeHandler(true));
+  }
+  function tippyHover(el, contentFn) {
+    const config = {
+      allowHTML: true,
+      content: contentFn,
+      maxWidth: 500,
+      delay: 100,
+      arrow: false,
+      appendTo: function(el) {
+          return el.parentElement;
+      },
+      interactive: true,
+      interactiveBorder: 10,
+      theme: 'quarto',
+      placement: 'bottom-start'
+    };
+    window.tippy(el, config); 
+  }
+  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
+  for (var i=0; i<noterefs.length; i++) {
+    const ref = noterefs[i];
+    tippyHover(ref, function() {
+      // use id or data attribute instead here
+      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
+      try { href = new URL(href).hash; } catch {}
+      const id = href.replace(/^#\/?/, "");
+      const note = window.document.getElementById(id);
+      return note.innerHTML;
+    });
+  }
+      let selectedAnnoteEl;
+      const selectorForAnnotation = ( cell, annotation) => {
+        let cellAttr = 'data-code-cell="' + cell + '"';
+        let lineAttr = 'data-code-annotation="' +  annotation + '"';
+        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
+        return selector;
+      }
+      const selectCodeLines = (annoteEl) => {
+        const doc = window.document;
+        const targetCell = annoteEl.getAttribute("data-target-cell");
+        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
+        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
+        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
+        const lineIds = lines.map((line) => {
+          return targetCell + "-" + line;
+        })
+        let top = null;
+        let height = null;
+        let parent = null;
+        if (lineIds.length > 0) {
+            //compute the position of the single el (top and bottom and make a div)
+            const el = window.document.getElementById(lineIds[0]);
+            top = el.offsetTop;
+            height = el.offsetHeight;
+            parent = el.parentElement.parentElement;
+          if (lineIds.length > 1) {
+            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
+            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
+            height = bottom - top;
+          }
+          if (top !== null && height !== null && parent !== null) {
+            // cook up a div (if necessary) and position it 
+            let div = window.document.getElementById("code-annotation-line-highlight");
+            if (div === null) {
+              div = window.document.createElement("div");
+              div.setAttribute("id", "code-annotation-line-highlight");
+              div.style.position = 'absolute';
+              parent.appendChild(div);
+            }
+            div.style.top = top - 2 + "px";
+            div.style.height = height + 4 + "px";
+            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
+            if (gutterDiv === null) {
+              gutterDiv = window.document.createElement("div");
+              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
+              gutterDiv.style.position = 'absolute';
+              const codeCell = window.document.getElementById(targetCell);
+              const gutter = codeCell.querySelector('.code-annotation-gutter');
+              gutter.appendChild(gutterDiv);
+            }
+            gutterDiv.style.top = top - 2 + "px";
+            gutterDiv.style.height = height + 4 + "px";
+          }
+          selectedAnnoteEl = annoteEl;
+        }
+      };
+      const unselectCodeLines = () => {
+        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
+        elementsIds.forEach((elId) => {
+          const div = window.document.getElementById(elId);
+          if (div) {
+            div.remove();
+          }
+        });
+        selectedAnnoteEl = undefined;
+      };
+      // Attach click handler to the DT
+      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
+      for (const annoteDlNode of annoteDls) {
+        annoteDlNode.addEventListener('click', (event) => {
+          const clickedEl = event.target;
+          if (clickedEl !== selectedAnnoteEl) {
+            unselectCodeLines();
+            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
+            if (activeEl) {
+              activeEl.classList.remove('code-annotation-active');
+            }
+            selectCodeLines(clickedEl);
+            clickedEl.classList.add('code-annotation-active');
+          } else {
+            // Unselect the line
+            unselectCodeLines();
+            clickedEl.classList.remove('code-annotation-active');
+          }
+        });
+      }
+  const findCites = (el) => {
+    const parentEl = el.parentElement;
+    if (parentEl) {
+      const cites = parentEl.dataset.cites;
+      if (cites) {
+        return {
+          el,
+          cites: cites.split(' ')
+        };
+      } else {
+        return findCites(el.parentElement)
+      }
+    } else {
+      return undefined;
+    }
+  };
+  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
+  for (var i=0; i<bibliorefs.length; i++) {
+    const ref = bibliorefs[i];
+    const citeInfo = findCites(ref);
+    if (citeInfo) {
+      tippyHover(citeInfo.el, function() {
+        var popup = window.document.createElement('div');
+        citeInfo.cites.forEach(function(cite) {
+          var citeDiv = window.document.createElement('div');
+          citeDiv.classList.add('hanging-indent');
+          citeDiv.classList.add('csl-entry');
+          var biblioDiv = window.document.getElementById('ref-' + cite);
+          if (biblioDiv) {
+            citeDiv.innerHTML = biblioDiv.innerHTML;
+          }
+          popup.appendChild(citeDiv);
+        });
+        return popup.innerHTML;
+      });
+    }
+  }
+});
+</script><script src="https://giscus.app/client.js" data-repo="insightsengineering/tlg-catalog" data-repo-id="MDEwOlJlcG9zaXRvcnk0MDYxNTcwMjg=" data-category="General" data-category-id="DIC_kwDOGDV25M4CVBzs" data-mapping="pathname" data-reactions-enabled="1" data-emit-metadata="0" data-input-position="top" data-theme="light" data-lang="en" crossorigin="anonymous" data-loading="lazy" async="">
+</script><div class="modal fade" id="quarto-embedded-source-code-modal" tabindex="-1" aria-labelledby="quarto-embedded-source-code-modal-label" aria-hidden="true"><div class="modal-dialog modal-dialog-scrollable"><div class="modal-content"><div class="modal-header"><h5 class="modal-title" id="quarto-embedded-source-code-modal-label">Source Code</h5><button class="btn-close" data-bs-dismiss="modal"></button></div><div class="modal-body"><div class="">
+<div class="sourceCode" id="cb1" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb1-1"><a href="#cb1-1"></a><span class="in">```{r save testenv, include=FALSE, opts.label='include_if_testing'}</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="co">#| renv.ignore: TRUE</span></span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="cf">if</span> (<span class="fu">exists</span>(<span class="st">"tenv"</span>)) {</span>
+<span id="cb1-4"><a href="#cb1-4"></a>  dirname <span class="ot">&lt;-</span> <span class="fu">Sys.getenv</span>(<span class="st">"QUARTO_TESTTHAT_DATA_PATH"</span>)</span>
+<span id="cb1-5"><a href="#cb1-5"></a>  filename <span class="ot">&lt;-</span> <span class="fu">paste0</span>(<span class="fu">gsub</span>(<span class="st">"</span><span class="sc">\\</span><span class="st">.rmarkdown$"</span>, <span class="st">""</span>, knitr<span class="sc">::</span><span class="fu">current_input</span>()), <span class="st">".rds"</span>)</span>
+<span id="cb1-6"><a href="#cb1-6"></a>  filepath <span class="ot">&lt;-</span> <span class="fu">file.path</span>(dirname, filename)</span>
+<span id="cb1-7"><a href="#cb1-7"></a>  <span class="fu">file.create</span>(filepath)</span>
+<span id="cb1-8"><a href="#cb1-8"></a>  <span class="fu">saveRDS</span>(tenv, filepath)</span>
+<span id="cb1-9"><a href="#cb1-9"></a>}</span>
+<span id="cb1-10"><a href="#cb1-10"></a><span class="in">```</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
+</div></div></div></div></div>
+</div> <!-- /content -->
+<footer class="footer"><div class="nav-footer">
+    <div class="nav-footer-left">Made with ❤️ by the NEST Team</div>   
+    <div class="nav-footer-center"><div class="cookie-consent-footer"><a href="#" id="open_preferences_center">Cookie Preferences</a></div></div>
+    <div class="nav-footer-right">
+      &nbsp;
+    </div>
+  </div>
+</footer>
+
+
+<script src="../site_libs/quarto-html/zenscroll-min.js"></script>
+</body></html>
\ No newline at end of file
diff --git a/stable/tlg-index.html b/stable/tlg-index.html
new file mode 100644
index 0000000000..3e5cc22661
--- /dev/null
+++ b/stable/tlg-index.html
@@ -0,0 +1,2541 @@
+<!DOCTYPE html>
+<html xmlns="http://www.w3.org/1999/xhtml" lang="en-US" xml:lang="en-US"><head>
+
+<meta charset="utf-8">
+<meta name="generator" content="quarto-1.3.450">
+
+<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
+
+
+<title>TLG Catalog - Index</title>
+<style>
+code{white-space: pre-wrap;}
+span.smallcaps{font-variant: small-caps;}
+div.columns{display: flex; gap: min(4vw, 1.5em);}
+div.column{flex: auto; overflow-x: auto;}
+div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
+ul.task-list{list-style: none;}
+ul.task-list li input[type="checkbox"] {
+  width: 0.8em;
+  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
+  vertical-align: middle;
+}
+/* CSS for syntax highlighting */
+pre > code.sourceCode { white-space: pre; position: relative; }
+pre > code.sourceCode > span { display: inline-block; line-height: 1.25; }
+pre > code.sourceCode > span:empty { height: 1.2em; }
+.sourceCode { overflow: visible; }
+code.sourceCode > span { color: inherit; text-decoration: inherit; }
+div.sourceCode { margin: 1em 0; }
+pre.sourceCode { margin: 0; }
+@media screen {
+div.sourceCode { overflow: auto; }
+}
+@media print {
+pre > code.sourceCode { white-space: pre-wrap; }
+pre > code.sourceCode > span { text-indent: -5em; padding-left: 5em; }
+}
+pre.numberSource code
+  { counter-reset: source-line 0; }
+pre.numberSource code > span
+  { position: relative; left: -4em; counter-increment: source-line; }
+pre.numberSource code > span > a:first-child::before
+  { content: counter(source-line);
+    position: relative; left: -1em; text-align: right; vertical-align: baseline;
+    border: none; display: inline-block;
+    -webkit-touch-callout: none; -webkit-user-select: none;
+    -khtml-user-select: none; -moz-user-select: none;
+    -ms-user-select: none; user-select: none;
+    padding: 0 4px; width: 4em;
+  }
+pre.numberSource { margin-left: 3em;  padding-left: 4px; }
+div.sourceCode
+  {   }
+@media screen {
+pre > code.sourceCode > span > a:first-child::before { text-decoration: underline; }
+}
+</style>
+
+
+<script src="site_libs/quarto-nav/quarto-nav.js"></script>
+<script src="site_libs/clipboard/clipboard.min.js"></script>
+<script src="site_libs/quarto-search/autocomplete.umd.js"></script>
+<script src="site_libs/quarto-search/fuse.min.js"></script>
+<script src="site_libs/quarto-search/quarto-search.js"></script>
+<meta name="quarto:offset" content="./">
+<link href="./assets/img/logo-nest.png" rel="icon" type="image/png">
+<script src="site_libs/cookie-consent/cookie-consent.js"></script>
+<link href="site_libs/cookie-consent/cookie-consent.css" rel="stylesheet">
+<script src="site_libs/quarto-html/quarto.js"></script>
+<script src="site_libs/quarto-html/popper.min.js"></script>
+<script src="site_libs/quarto-html/tippy.umd.min.js"></script>
+<script src="site_libs/quarto-html/anchor.min.js"></script>
+<link href="site_libs/quarto-html/tippy.css" rel="stylesheet">
+<link href="site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
+<link href="site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
+<script src="site_libs/bootstrap/bootstrap.min.js"></script>
+<link href="site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
+<link href="site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
+<link href="site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark">
+<script id="quarto-search-options" type="application/json">{
+  "location": "navbar",
+  "copy-button": true,
+  "collapse-after": 3,
+  "panel-placement": "end",
+  "type": "overlay",
+  "limit": 20,
+  "language": {
+    "search-no-results-text": "No results",
+    "search-matching-documents-text": "matching documents",
+    "search-copy-link-title": "Copy link to search",
+    "search-hide-matches-text": "Hide additional matches",
+    "search-more-match-text": "more match in this document",
+    "search-more-matches-text": "more matches in this document",
+    "search-clear-button-title": "Clear",
+    "search-detached-cancel-button-title": "Cancel",
+    "search-submit-button-title": "Submit",
+    "search-label": "Search"
+  }
+}</script>
+
+<script type="text/plain" cookie-consent="tracking">
+
+(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){
+  (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),
+  m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)
+  })(window,document,'script','https://www.google-analytics.com/analytics.js','ga');
+ga('create', 'UA-125641273-1', 'auto');
+
+ga('send', {
+  hitType: 'pageview',
+  'anonymizeIp': true,
+});
+</script>
+
+<script type="text/javascript" charset="UTF-8">
+document.addEventListener('DOMContentLoaded', function () {
+cookieconsent.run({
+  "notice_banner_type":"simple",
+  "consent_type":"implied",
+  "palette":"light",
+  "language":"en",
+  "page_load_consent_levels":["strictly-necessary","functionality","tracking","targeting"],
+  "notice_banner_reject_button_hide":false,
+  "preferences_center_close_button_hide":false,
+  "website_name":""
+  });
+});
+</script> 
+  
+<style>html{ scroll-behavior: smooth; }</style>
+
+  <script src="https://polyfill.io/v3/polyfill.min.js?features=es6"></script>
+  <script src="https://cdn.jsdelivr.net/npm/mathjax@3/es5/tex-chtml-full.js" type="text/javascript"></script>
+
+<link rel="stylesheet" href="assets/css/style.scss">
+<meta property="og:title" content="TLG Catalog - Index">
+<meta property="og:site-name" content="TLG Catalog">
+</head>
+
+<body class="nav-sidebar docked nav-fixed">
+
+
+<div id="quarto-search-results"></div>
+  <header id="quarto-header" class="headroom fixed-top">
+    <nav class="navbar navbar-expand navbar-dark ">
+      <div class="navbar-container container-fluid">
+      <div class="navbar-brand-container">
+    <a class="navbar-brand" href="./index.html">
+    <span class="navbar-title">TLG Catalog</span>
+    </a>
+  </div>
+          <ul class="navbar-nav navbar-nav-scroll ms-auto">
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://app.slack.com/client/T028PB489D3/" rel="" target=""><i class="bi bi-slack" role="img" aria-label="Slack">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item compact">
+    <a class="nav-link" href="https://github.com/insightsengineering/tlg-catalog" rel="" target=""><i class="bi bi-github" role="img" aria-label="Repository">
+</i> 
+ <span class="menu-text"></span></a>
+  </li>  
+  <li class="nav-item dropdown ">
+    <a class="nav-link dropdown-toggle" href="#" id="nav-menu-version" role="button" data-bs-toggle="dropdown" aria-expanded="false" rel="" target="">
+ <span class="menu-text">Version</span>
+    </a>
+    <ul class="dropdown-menu dropdown-menu-end" aria-labelledby="nav-menu-version">    
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/development" rel="" target="">
+ <span class="dropdown-text">Development</span></a>
+  </li>  
+        <li>
+    <a class="dropdown-item" href="https://insightsengineering.github.io/tlg-catalog/stable" rel="" target="">
+ <span class="dropdown-text">Stable</span></a>
+  </li>  
+    </ul>
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+</ul>
+          <div class="quarto-navbar-tools">
+  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
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+  <i class="bi"></i>
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+      </div> <!-- /container-fluid -->
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+  <nav class="quarto-secondary-nav">
+    <div class="container-fluid d-flex">
+      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
+        <i class="bi bi-layout-text-sidebar-reverse"></i>
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+      <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item"><a href="./tlg-index.html">Index</a></li></ol></nav>
+      <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
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+<!-- content -->
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+<!-- sidebar -->
+  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation docked overflow-auto">
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+      <img src="./assets/img/logo-nest.png" alt="" class="sidebar-logo py-0 d-lg-inline d-none">
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+      </div>
+    <div class="sidebar-menu-container"> 
+    <ul class="list-unstyled mt-1">
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./index.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Introduction</span></a>
+  </div>
+</li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false">
+ <span class="menu-text">Tables</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="false" aria-label="Toggle section">
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+      </div>
+      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ADA/adat04b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAT04B</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet01_aesi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET01_AESI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet02_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET02_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet04_pi.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET04_PI</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet05_all.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET05_ALL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet06_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET06_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet09_smq.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET09_SMQ</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/adverse-events/aet10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AET10</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt01b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT01B</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/concomitant-medications/cmt02_pt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMT02_PT</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false">
+ <span class="menu-text">Deaths</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/deaths/dtht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DTHT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false">
+ <span class="menu-text">Demography</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-6" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-6" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/demography/dmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DMT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false">
+ <span class="menu-text">Disclosures</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-7" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-7" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/disclosurest01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DISCLOSUREST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disclosures/eudrat02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EUDRAT02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-8" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-8" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/dst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/disposition/pdt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PDT02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-9" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-9" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/ECG/egt05_qtcat.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGT05_QTCAT</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-10" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-10" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/aovt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AOVT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cfbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CFBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/cmht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CMHT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/coxt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">COXT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/dort01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DORT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/lgrt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LGRT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/mmrmt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/onct05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ratet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RATET01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rbmit01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RBMIT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/rspt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RSPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/efficacy/ttet01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">TTET01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-11" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-11" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/exposure/ext01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-12" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-12" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt09.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT09</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt10_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT10_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt11_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT11_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt12_bl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT12_BL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt13.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT13</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt14.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT14</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/lab-results/lbt15.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBT15</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-13" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-13" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/medical-history/mht01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHT01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-14" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-14" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkct01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT06</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt07.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT07</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt08.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT08</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/pharmacokinetic/pkpt11.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPT11</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false">
+ <span class="menu-text">Risk Management Plan</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-15" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-15" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt05.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT05</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/risk-management-plan/rmpt06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">RMPT06</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false">
+ <span class="menu-text">Safety</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-16" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-16" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/safety/enrollment01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ENTXX</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-17" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-17" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tables/vital-signs/vst02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VST02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false">
+ <span class="menu-text">Listings</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-18" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-18" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false">
+ <span class="menu-text">ADA</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-19" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-19" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ADA/adal02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ADAL02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false">
+ <span class="menu-text">Adverse Events</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-20" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-20" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael01_nollt.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL01_NOLLT</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael02_ed.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL02_ED</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/adverse-events/ael04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">AEL04</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false">
+ <span class="menu-text">Concomitant Medications</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-21" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-21" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02a_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02A_GL</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/concomitant-medications/cml02b_gl.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CML02B_GL</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false">
+ <span class="menu-text">Development Safety Update Report</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-22" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-22" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/development-safety-update-report/dsur4.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSUR4</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false">
+ <span class="menu-text">Disposition</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-23" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-23" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/disposition/dsl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">DSL02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false">
+ <span class="menu-text">ECG</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-24" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-24" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/ECG/egl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EGL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-25" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-25" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/efficacy/oncl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">ONCL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false">
+ <span class="menu-text">Exposure</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-26" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-26" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/exposure/exl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">EXL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false">
+ <span class="menu-text">Lab Results</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-27" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-27" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl01_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL01_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02a_rls.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02A_RLS</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/lab-results/lbl02b.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LBL02B</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false">
+ <span class="menu-text">Medical History</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-28" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-28" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/medical-history/mhl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MHL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-29" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-29" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkcl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/pharmacokinetic/pkpl04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPL04</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false">
+ <span class="menu-text">Vital Signs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-30" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-30" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./listings/vital-signs/vsl01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">VSL01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false">
+ <span class="menu-text">Graphs</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-31" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-31" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false">
+ <span class="menu-text">Efficacy</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-32" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-32" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/fstg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">FSTG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/efficacy/mmrmg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MMRMG02</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false">
+ <span class="menu-text">Other</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-33" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-33" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/brg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BRG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/bwg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">BWG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/cig01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">CIG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ippg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">IPPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/kmg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">KMG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/ltg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">LTG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/other/mng01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">MNG01</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+          <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false">
+ <span class="menu-text">Pharmacokinetic</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-34" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-34" class="collapse list-unstyled sidebar-section depth2 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkcg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKCG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg01.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG01</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg02.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG02</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg03.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG03</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg04.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG04</span></a>
+  </div>
+</li>
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./graphs/pharmacokinetic/pkpg06.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">PKPG06</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+      </ul>
+  </li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item sidebar-item-section">
+      <div class="sidebar-item-container"> 
+            <a class="sidebar-item-text sidebar-link text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false">
+ <span class="menu-text">Appendix</span></a>
+          <a class="sidebar-item-toggle text-start collapsed" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-35" aria-expanded="false" aria-label="Toggle section">
+            <i class="bi bi-chevron-right ms-2"></i>
+          </a> 
+      </div>
+      <ul id="quarto-sidebar-section-35" class="collapse list-unstyled sidebar-section depth1 ">  
+          <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./appendix/reproducibility.html" class="sidebar-item-text sidebar-link">
+ <span class="menu-text">Reproducibility</span></a>
+  </div>
+</li>
+      </ul>
+  </li>
+        <li class="px-0"><hr class="sidebar-divider hi "></li>
+        <li class="sidebar-item">
+  <div class="sidebar-item-container"> 
+  <a href="./tlg-index.html" class="sidebar-item-text sidebar-link active">
+ <span class="menu-text">Index</span></a>
+  </div>
+</li>
+    </ul>
+    </div>
+</nav>
+<div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
+<!-- margin-sidebar -->
+    <div id="quarto-margin-sidebar" class="sidebar margin-sidebar">
+        <nav id="TOC" role="doc-toc" class="toc-active">
+    <h2 id="toc-title">On this page</h2>
+   
+  <ul>
+  <li><a href="#tables" id="toc-tables" class="nav-link active" data-scroll-target="#tables"><strong>Tables</strong></a>
+  <ul>
+  <li><a href="#ada" id="toc-ada" class="nav-link" data-scroll-target="#ada">ADA</a></li>
+  <li><a href="#adverse-events" id="toc-adverse-events" class="nav-link" data-scroll-target="#adverse-events">Adverse Events</a></li>
+  <li><a href="#concomitant-medications" id="toc-concomitant-medications" class="nav-link" data-scroll-target="#concomitant-medications">Concomitant Medications</a></li>
+  <li><a href="#deaths" id="toc-deaths" class="nav-link" data-scroll-target="#deaths">Deaths</a></li>
+  <li><a href="#demography" id="toc-demography" class="nav-link" data-scroll-target="#demography">Demography</a></li>
+  <li><a href="#disclosures" id="toc-disclosures" class="nav-link" data-scroll-target="#disclosures">Disclosures</a></li>
+  <li><a href="#disposition" id="toc-disposition" class="nav-link" data-scroll-target="#disposition">Disposition</a></li>
+  <li><a href="#ecg" id="toc-ecg" class="nav-link" data-scroll-target="#ecg">ECG</a></li>
+  <li><a href="#efficacy" id="toc-efficacy" class="nav-link" data-scroll-target="#efficacy">Efficacy</a></li>
+  <li><a href="#exposure" id="toc-exposure" class="nav-link" data-scroll-target="#exposure">Exposure</a></li>
+  <li><a href="#lab-results" id="toc-lab-results" class="nav-link" data-scroll-target="#lab-results">Lab Results</a></li>
+  <li><a href="#medical-history" id="toc-medical-history" class="nav-link" data-scroll-target="#medical-history">Medical History</a></li>
+  <li><a href="#pharmacokinetic" id="toc-pharmacokinetic" class="nav-link" data-scroll-target="#pharmacokinetic">Pharmacokinetic</a></li>
+  <li><a href="#risk-management-plan" id="toc-risk-management-plan" class="nav-link" data-scroll-target="#risk-management-plan">Risk Management Plan</a></li>
+  <li><a href="#safety" id="toc-safety" class="nav-link" data-scroll-target="#safety">Safety</a></li>
+  <li><a href="#vital-signs" id="toc-vital-signs" class="nav-link" data-scroll-target="#vital-signs">Vital Signs</a></li>
+  </ul></li>
+  <li><a href="#listings" id="toc-listings" class="nav-link" data-scroll-target="#listings"><strong>Listings</strong></a>
+  <ul>
+  <li><a href="#ada-1" id="toc-ada-1" class="nav-link" data-scroll-target="#ada-1">ADA</a></li>
+  <li><a href="#adverse-events-1" id="toc-adverse-events-1" class="nav-link" data-scroll-target="#adverse-events-1">Adverse Events</a></li>
+  <li><a href="#concomitant-medications-1" id="toc-concomitant-medications-1" class="nav-link" data-scroll-target="#concomitant-medications-1">Concomitant Medications</a></li>
+  <li><a href="#disposition-1" id="toc-disposition-1" class="nav-link" data-scroll-target="#disposition-1">Disposition</a></li>
+  <li><a href="#development-safety-update-report" id="toc-development-safety-update-report" class="nav-link" data-scroll-target="#development-safety-update-report">Development Safety Update Report</a></li>
+  <li><a href="#ecg-1" id="toc-ecg-1" class="nav-link" data-scroll-target="#ecg-1">ECG</a></li>
+  <li><a href="#exposure-1" id="toc-exposure-1" class="nav-link" data-scroll-target="#exposure-1">Exposure</a></li>
+  <li><a href="#lab-results-1" id="toc-lab-results-1" class="nav-link" data-scroll-target="#lab-results-1">Lab Results</a></li>
+  <li><a href="#medical-history-1" id="toc-medical-history-1" class="nav-link" data-scroll-target="#medical-history-1">Medical History</a></li>
+  <li><a href="#pharmacokinetic-1" id="toc-pharmacokinetic-1" class="nav-link" data-scroll-target="#pharmacokinetic-1">Pharmacokinetic</a></li>
+  <li><a href="#vital-signs-1" id="toc-vital-signs-1" class="nav-link" data-scroll-target="#vital-signs-1">Vital Signs</a></li>
+  </ul></li>
+  <li><a href="#graphs" id="toc-graphs" class="nav-link" data-scroll-target="#graphs"><strong>Graphs</strong></a>
+  <ul>
+  <li><a href="#efficacy-1" id="toc-efficacy-1" class="nav-link" data-scroll-target="#efficacy-1">Efficacy</a></li>
+  <li><a href="#pharmacokinetic-2" id="toc-pharmacokinetic-2" class="nav-link" data-scroll-target="#pharmacokinetic-2">Pharmacokinetic</a></li>
+  <li><a href="#other" id="toc-other" class="nav-link" data-scroll-target="#other">Other</a></li>
+  </ul></li>
+  </ul>
+</nav>
+    </div>
+<!-- main -->
+<main class="content column-body" id="quarto-document-content">
+
+<header id="title-block-header" class="quarto-title-block default">
+<div class="quarto-title">
+<div class="quarto-title-block"><div><h1 class="title">Index</h1><button type="button" class="btn code-tools-button" id="quarto-code-tools-source"><i class="bi"></i></button></div></div>
+</div>
+
+
+
+<div class="quarto-title-meta">
+
+    
+  
+    
+  </div>
+  
+
+</header>
+
+<hr>
+<section id="tables" class="level3">
+<h3 class="anchored" data-anchor-id="tables"><strong>Tables</strong></h3>
+<section id="ada" class="level4">
+<h4 class="anchored" data-anchor-id="ada">ADA</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ADA/adat01.html">ADAT01 – Baseline Prevalence and Incidence of Treatment Emergent ADA</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ADA/adat02.html">ADAT02 – Summary of Patients with Treatment-Induced ADA</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ADA/adat03.html">ADAT03 – Summary of Serum Concentrations at Timepoints Where ADA Samples Were Collected and Analyzed</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ADA/adat04a.html">ADAT04A – Baseline Prevalence and Incidence of Treatment Emergent NAbs</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ADA/adat04b.html">ADAT04B – Baseline Prevalence and Incidence of NAbs</a></p>
+</section>
+<section id="adverse-events" class="level4">
+<h4 class="anchored" data-anchor-id="adverse-events">Adverse Events</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet01.html">AET01 – Safety Summary</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet01_aesi.html">AET01_AESI – Safety Summary (Adverse Events of Special Interest)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet02.html">AET02 – Adverse Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet02_smq.html">AET02_SMQ – Adverse Events by Standardized MedDRA Query</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet03.html">AET03 – Adverse Events by Greatest Intensity</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet04.html">AET04 – Adverse Events by Highest NCI CTCAE Grade</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet04_pi.html">AET04_PI – Adverse Events Reported in <span class="math inline">\(\geq\)</span> 10% of Patients by Highest NCI CTCAE Grade</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet05.html">AET05 – Adverse Event Rate Adjusted for Patient-Years at Risk – First Occurrence</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet05_all.html">AET05_ALL – Adverse Event Rate Adjusted for Patient-Years at Risk – All Occurrences</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet06.html">AET06 – Adverse Events by Baseline Characteristic</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet06_smq.html">AET06_SMQ – Adverse Events by Baseline Characteristic, by SMQ and Preferred Term</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet07.html">AET07 – Adverse Events Resulting in Death</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet09.html">AET09 – Adverse Events Related to Study Drug</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet09_smq.html">AET09_SMQ – Adverse Events Related to Study Drug by Standardized MedDRA Query</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/adverse-events/aet10.html">AET10 – Most Common (<span class="math inline">\(\geq\)</span> 5%) Adverse Events</a></p>
+</section>
+<section id="concomitant-medications" class="level4">
+<h4 class="anchored" data-anchor-id="concomitant-medications">Concomitant Medications</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/concomitant-medications/cmt01.html">CMT01 – Concomitant Medications (GNEDrug Legacy Coding)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/concomitant-medications/cmt01a.html">CMT01A – Concomitant Medications by Medication Class and Preferred Name</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/concomitant-medications/cmt01b.html">CMT01B – Concomitant Medications by Medication Class and Preferred Name</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/concomitant-medications/cmt02_pt.html">CMT02_PT – Concomitant Medications by Preferred Name (WHODrug Coding)</a></p>
+</section>
+<section id="deaths" class="level4">
+<h4 class="anchored" data-anchor-id="deaths">Deaths</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/deaths/dtht01.html">DTHT01 – Deaths</a></p>
+</section>
+<section id="demography" class="level4">
+<h4 class="anchored" data-anchor-id="demography">Demography</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/demography/dmt01.html">DMT01 – Demographics and Baseline Characteristics</a></p>
+</section>
+<section id="disclosures" class="level4">
+<h4 class="anchored" data-anchor-id="disclosures">Disclosures</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disclosures/disclosurest01.html">DISCLOSUREST01 – Disclosures Outputs</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disclosures/eudrat01.html">EUDRAT01 – Non-Serious Adverse Events Reported in <span class="math inline">\(\geq\)</span> 5% of Patients in Any Treatment Group – Patients and Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disclosures/eudrat02.html">EUDRAT02 – Serious Adverse Events, Fatal Serious Adverse Events, and Serious Adverse Events Related to Study Medication</a></p>
+</section>
+<section id="disposition" class="level4">
+<h4 class="anchored" data-anchor-id="disposition">Disposition</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disposition/dst01.html">DST01 – Patient Disposition</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disposition/pdt01.html">PDT01 – Major Protocol Deviations</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/disposition/pdt02.html">PDT02 – Major Protocol Deviations Related to Epidemic/Pandemic</a></p>
+</section>
+<section id="ecg" class="level4">
+<h4 class="anchored" data-anchor-id="ecg">ECG</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ECG/egt01.html">EGT01 – ECG Results and Change from Baseline by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ECG/egt02.html">EGT02 – ECG Abnormalities (EGT02_1 &amp; EGT02_2)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ECG/egt03.html">EGT03 – Shift Table of ECG Interval Data – Baseline Versus Minimum/Maximum Post-Baseline</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ECG/egt04.html">EGT04 – Shift Table of Qualitative ECG Assessments</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/ECG/egt05_qtcat.html">EGT05_QTCAT – ECG Actual Values and Changes from Baseline by Visit</a></p>
+</section>
+<section id="efficacy" class="level4">
+<h4 class="anchored" data-anchor-id="efficacy">Efficacy</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/aovt01.html">AOVT01 – ANCOVA for Multiple End Points</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/aovt02.html">AOVT02 – ANCOVA with Single End Point and Customized Table</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/aovt03.html">AOVT03 – ANCOVA with Consideration of Interaction</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/cfbt01.html">CFBT01 – Efficacy Data and Change from Baseline by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/cmht01.html">CMHT01 – Cochran-Mantel-Haenszel (CMH) Summary</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/coxt01.html">COXT01 – Cox Regression</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/coxt02.html">COXT02 – Multivariable Cox Regression</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/dort01.html">DORT01 – Duration of Response</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/lgrt02.html">LGRT02 – Multi-Variable Logistic Regression</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/mmrmt01.html">MMRMT01 – Tables for Mixed-Effect Model Repeated Measures Analysis</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/onct05.html">ONCT05 – Objective Response Rate by Subgroup</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/ratet01.html">RATET01 – Event Rate Summary for Recurrent Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/rbmit01.html">RBMIT01 – Tables for RBMI</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/rspt01.html">RSPT01 – Best Overall Response</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/efficacy/ttet01.html">TTET01 – Time-To-Event Summary</a></p>
+</section>
+<section id="exposure" class="level4">
+<h4 class="anchored" data-anchor-id="exposure">Exposure</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/exposure/ext01.html">EXT01 – Study Drug Exposure Table</a></p>
+</section>
+<section id="lab-results" class="level4">
+<h4 class="anchored" data-anchor-id="lab-results">Lab Results</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt01.html">LBT01 – Laboratory Test Results and Change from Baseline by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt02.html">LBT02 – Laboratory Test Results by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt03.html">LBT03 – Laboratory Test Results Change from Baseline by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt04.html">LBT04 – Laboratory Abnormalities Not Present at Baseline</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt05.html">LBT05 – Laboratory Abnormalities with Single and Replicated Marked</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt06.html">LBT06 – Laboratory Abnormalities by Visit and Baseline Status</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt07.html">LBT07 – Laboratory Test Results with Highest NCI CTCAE Grade Post-Baseline</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt08.html">LBT08 – Laboratory Test Results with Highest NCI CTCAE Grade at Any Time</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt09.html">LBT09 – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt10.html">LBT10 – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to ULN)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt10_bl.html">LBT10_BL – Liver Laboratory Tests – Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to Baseline)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt11.html">LBT11 – Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to ULN)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt11_bl.html">LBT11_BL – Time to First Increase in Liver Laboratory Test Result Meeting Hy’s Law Laboratory Critieria (with Respect to Baseline)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt12.html">LBT12 – Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to ULN)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt12_bl.html">LBT12_BL – Liver Laboratory Tests by Time on Treatment – Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to Baseline)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt13.html">LBT13 – NCI CTCAE Grade Laboratory Abnormalities by Visit and Baseline Grade</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt14.html">LBT14 – Laboratory Test Results Shift Table – Highest NCI CTCAE Grade Post-Baseline by Baseline NCI CTCAE Grade</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/lab-results/lbt15.html">LBT15 – Laboratory Test Shifts to NCI CTCAE Grade 3-4 Post-Baseline</a></p>
+</section>
+<section id="medical-history" class="level4">
+<h4 class="anchored" data-anchor-id="medical-history">Medical History</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/medical-history/mht01.html">MHT01 – Medical History</a></p>
+</section>
+<section id="pharmacokinetic" class="level4">
+<h4 class="anchored" data-anchor-id="pharmacokinetic">Pharmacokinetic</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkct01.html">PKCT01 – Summary Concentration Table</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt02.html">PKPT02 – Pharmacokinetic Parameter Summary – Plasma/Serum/Blood PK Parameters (Stats in Rows)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt03.html">PKPT03 – Pharmacokinetic Parameter Summary of Plasma by Treatment (Stats in Columns)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt04.html">PKPT04 – Pharmacokinetic Parameter Summary – Urine PK Parameters (Stats in Rows)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt05.html">PKPT05 – Summary of Urinary PK Parameters by Treatment Arm (Stats in Columns)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt06.html">PKPT06 – Pharmacokinetic Parameter Summary – Dose-Normalized PK Parameters (Stats in Rows)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt07.html">PKPT07 – Table of Mean Dose-Normalized Selected Pharmacokinetic Parameters (Stats in Columns)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt08.html">PKPT08 – Pharmacokinetic Parameter Summary of Cumulative Amount of Drug Eliminated and Cumulative Percentage of Drug Recovered (Stats in Columns)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/pharmacokinetic/pkpt11.html">PKPT11 – Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX</a></p>
+</section>
+<section id="risk-management-plan" class="level4">
+<h4 class="anchored" data-anchor-id="risk-management-plan">Risk Management Plan</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/risk-management-plan/rmpt01.html">RMPT01 – Duration of Exposure for Risk Management Plan</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/risk-management-plan/rmpt03.html">RMPT03 – Extent of Exposure by Age Group and Gender for Risk Management Plan</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/risk-management-plan/rmpt04.html">RMPT04 – Extent of Exposure by Ethnic Origin for Risk Management Plan</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/risk-management-plan/rmpt05.html">RMPT05 – Extent of Exposure by Race for Risk Management Plan</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/risk-management-plan/rmpt06.html">RMPT06 – Seriousness, Outcomes, Severity, Frequency with 95% CI for Risk Management Plan</a></p>
+</section>
+<section id="safety" class="level4">
+<h4 class="anchored" data-anchor-id="safety">Safety</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/safety/enrollment01.html">ENTXX – Enrollment Variants</a></p>
+</section>
+<section id="vital-signs" class="level4">
+<h4 class="anchored" data-anchor-id="vital-signs">Vital Signs</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/vital-signs/vst01.html">VST01 – Vital Sign Results and Change from Baseline by Visit</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./tables/vital-signs/vst02.html">VST02 – Vital Sign Abnormalities</a></p>
+<hr>
+</section>
+</section>
+<section id="listings" class="level3">
+<h3 class="anchored" data-anchor-id="listings"><strong>Listings</strong></h3>
+<section id="ada-1" class="level4">
+<h4 class="anchored" data-anchor-id="ada-1">ADA</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/ADA/adal02.html">ADAL02 – Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients</a></p>
+</section>
+<section id="adverse-events-1" class="level4">
+<h4 class="anchored" data-anchor-id="adverse-events-1">Adverse Events</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael01.html">AEL01 – Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael01_nollt.html">AEL01_NOLLT – Listing of Preferred Terms and Investigator-Specified Adverse Event Terms</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael02.html">AEL02 – Listing of Adverse Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael02_ed.html">AEL02_ED – Listing of Adverse Events (for Early Development Studies)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael03.html">AEL03 – Listing of Serious Adverse Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/adverse-events/ael04.html">AEL04 – Listing of Patient Deaths</a></p>
+</section>
+<section id="concomitant-medications-1" class="level4">
+<h4 class="anchored" data-anchor-id="concomitant-medications-1">Concomitant Medications</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/concomitant-medications/cml01.html">CML01 – Listing of Previous and Concomitant Medications</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/concomitant-medications/cml02a_gl.html">CML02A_GL – Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/concomitant-medications/cml02b_gl.html">CML02B_GL – Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms</a></p>
+</section>
+<section id="disposition-1" class="level4">
+<h4 class="anchored" data-anchor-id="disposition-1">Disposition</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/disposition/dsl01.html">DSL01 – Listing of Patients with Study Drug Withdrawn Due to Adverse Events</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/disposition/dsl02.html">DSL02 – Listing of Patients Who Discontinued Early from Study</a></p>
+</section>
+<section id="development-safety-update-report" class="level4">
+<h4 class="anchored" data-anchor-id="development-safety-update-report">Development Safety Update Report</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/development-safety-update-report/dsur4.html">DSUR4 – Listing of Patients Who Died During Reporting Period</a></p>
+</section>
+<section id="ecg-1" class="level4">
+<h4 class="anchored" data-anchor-id="ecg-1">ECG</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/ECG/egl01.html">EGL01 – ‘Listing of ECG Data: Safety-Evaluable Patients’</a></p>
+</section>
+<section id="exposure-1" class="level4">
+<h4 class="anchored" data-anchor-id="exposure-1">Exposure</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/exposure/exl01.html">EXL01 – Listing of Exposure to Study Drug</a></p>
+</section>
+<section id="lab-results-1" class="level4">
+<h4 class="anchored" data-anchor-id="lab-results-1">Lab Results</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/lab-results/lbl01.html">LBL01 – Listing of Laboratory Test Results</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/lab-results/lbl01_rls.html">LBL01_RLS – Listing of Laboratory Test Results Using Roche Safety Lab Standardization</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/lab-results/lbl02a.html">LBL02A – Listing of Laboratory Abnormalities (constant units)</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/lab-results/lbl02a_rls.html">LBL02A_RLS – Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/lab-results/lbl02b.html">LBL02B – Listing of Laboratory Abnormalities (variable units)</a></p>
+</section>
+<section id="medical-history-1" class="level4">
+<h4 class="anchored" data-anchor-id="medical-history-1">Medical History</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/medical-history/mhl01.html">MHL01 – Listing of Medical History and Concurrent Diseases</a></p>
+</section>
+<section id="pharmacokinetic-1" class="level4">
+<h4 class="anchored" data-anchor-id="pharmacokinetic-1">Pharmacokinetic</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/pharmacokinetic/pkcl01.html">PKCL01 – Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/pharmacokinetic/pkcl02.html">PKCL02 – Listing of Drug A Urine Concentration and Volumes</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/pharmacokinetic/pkpl01.html">PKPL01 – Listing of Drug A Plasma PK Parameters</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/pharmacokinetic/pkpl02.html">PKPL02 – Listing of Drug A Urine PK Parameters</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/pharmacokinetic/pkpl04.html">PKPL04 – Listing of Individual Drug A AUCIFO and CMAX Ratios Following Drug A or Drug B</a></p>
+</section>
+<section id="vital-signs-1" class="level4">
+<h4 class="anchored" data-anchor-id="vital-signs-1">Vital Signs</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./listings/vital-signs/vsl01.html">VSL01 – ‘Listing of Vital Signs: Safety-Evaluable Patients’</a></p>
+<hr>
+</section>
+</section>
+<section id="graphs" class="level3">
+<h3 class="anchored" data-anchor-id="graphs"><strong>Graphs</strong></h3>
+<section id="efficacy-1" class="level4">
+<h4 class="anchored" data-anchor-id="efficacy-1">Efficacy</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/efficacy/fstg01.html">FSTG01 – Subgroup Analysis of Best Overall Response</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/efficacy/fstg02.html">FSTG02 – Subgroup Analysis of Survival Duration</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/efficacy/mmrmg01.html">MMRMG01 – Plots for Mixed-Effect Model Repeated Measures Analysis</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/efficacy/mmrmg02.html">MMRMG02 – Forest Plot for Mixed-Effect Model Repeated Measures</a></p>
+</section>
+<section id="pharmacokinetic-2" class="level4">
+<h4 class="anchored" data-anchor-id="pharmacokinetic-2">Pharmacokinetic</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkcg01.html">PKCG01 – Plot of PK Concentration Over Time by Subject</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkcg02.html">PKCG02 – Plot of PK Concentration Over Time by Cohort/Treatment Group/Dose</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkcg03.html">PKCG03 – Plot of Mean PK Concentration Over Time by Cohort</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkpg01.html">PKPG01 – Plot of Mean Cumulative Percentage (%) of Recovered Drug in Urine</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkpg02.html">PKPG02 – Pharmacokinetic Parameter Summary of Serum PK Parameters by Treatment</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkpg03.html">PKPG03 – Box Plot of Pharmacokinetic Parameters by Visit – Plasma</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkpg04.html">PKPG04 – Box Plot of Pharmacokinetic Parameters by Visit – Plasma</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/pharmacokinetic/pkpg06.html">PKPG06 – Boxplot of Metabolite to Parent Ratios by Treatment</a></p>
+</section>
+<section id="other" class="level4">
+<h4 class="anchored" data-anchor-id="other">Other</h4>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/brg01.html">BRG01 – Bar Chart</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/bwg01.html">BWG01 – Box Plot</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/cig01.html">CIG01 – Confidence Interval Plot</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/ippg01.html">IPPG01 – Individual Patient Plot Over Time</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/kmg01.html">KMG01 – Kaplan-Meier Plot</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/ltg01.html">LTG01 – Lattice Plot of Laboratory Tests by Treatment Group Over Time</a></p>
+<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="./graphs/other/mng01.html">MNG01 – Mean Plot</a></p>
+
+
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+
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+<div class="sourceCode" id="cb1" data-shortcodes="false"><pre class="sourceCode numberSource markdown number-lines code-with-copy"><code class="sourceCode markdown"><span id="cb1-1"><a href="#cb1-1"></a><span class="co">---</span></span>
+<span id="cb1-2"><a href="#cb1-2"></a><span class="an">title:</span><span class="co"> Index</span></span>
+<span id="cb1-3"><a href="#cb1-3"></a><span class="an">toc:</span><span class="co"> true</span></span>
+<span id="cb1-4"><a href="#cb1-4"></a><span class="an">toc-depth:</span><span class="co"> 4</span></span>
+<span id="cb1-5"><a href="#cb1-5"></a><span class="co">---</span></span>
+<span id="cb1-6"><a href="#cb1-6"></a></span>
+<span id="cb1-7"><a href="#cb1-7"></a>------------------------------------------------------------------------</span>
+<span id="cb1-8"><a href="#cb1-8"></a></span>
+<span id="cb1-9"><a href="#cb1-9"></a><span class="fu">### **Tables**</span></span>
+<span id="cb1-10"><a href="#cb1-10"></a></span>
+<span id="cb1-11"><a href="#cb1-11"></a><span class="fu">#### ADA</span></span>
+<span id="cb1-12"><a href="#cb1-12"></a></span>
+<span id="cb1-13"><a href="#cb1-13"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAT01 -- Baseline Prevalence and Incidence of Treatment Emergent ADA</span><span class="co">](./tables/ADA/adat01.qmd)</span></span>
+<span id="cb1-14"><a href="#cb1-14"></a></span>
+<span id="cb1-15"><a href="#cb1-15"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAT02 -- Summary of Patients with Treatment-Induced ADA</span><span class="co">](./tables/ADA/adat02.qmd)</span></span>
+<span id="cb1-16"><a href="#cb1-16"></a></span>
+<span id="cb1-17"><a href="#cb1-17"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAT03 -- Summary of Serum Concentrations at Timepoints Where ADA Samples Were Collected and Analyzed</span><span class="co">](./tables/ADA/adat03.qmd)</span></span>
+<span id="cb1-18"><a href="#cb1-18"></a></span>
+<span id="cb1-19"><a href="#cb1-19"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAT04A -- Baseline Prevalence and Incidence of Treatment Emergent NAbs</span><span class="co">](./tables/ADA/adat04a.qmd)</span></span>
+<span id="cb1-20"><a href="#cb1-20"></a></span>
+<span id="cb1-21"><a href="#cb1-21"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAT04B -- Baseline Prevalence and Incidence of NAbs</span><span class="co">](./tables/ADA/adat04b.qmd)</span></span>
+<span id="cb1-22"><a href="#cb1-22"></a></span>
+<span id="cb1-23"><a href="#cb1-23"></a></span>
+<span id="cb1-24"><a href="#cb1-24"></a><span class="fu">#### Adverse Events</span></span>
+<span id="cb1-25"><a href="#cb1-25"></a></span>
+<span id="cb1-26"><a href="#cb1-26"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET01 -- Safety Summary</span><span class="co">](./tables/adverse-events/aet01.qmd)</span></span>
+<span id="cb1-27"><a href="#cb1-27"></a></span>
+<span id="cb1-28"><a href="#cb1-28"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET01_AESI -- Safety Summary (Adverse Events of Special Interest)</span><span class="co">](./tables/adverse-events/aet01_aesi.qmd)</span></span>
+<span id="cb1-29"><a href="#cb1-29"></a></span>
+<span id="cb1-30"><a href="#cb1-30"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET02 -- Adverse Events</span><span class="co">](./tables/adverse-events/aet02.qmd)</span></span>
+<span id="cb1-31"><a href="#cb1-31"></a></span>
+<span id="cb1-32"><a href="#cb1-32"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET02_SMQ -- Adverse Events by Standardized MedDRA Query</span><span class="co">](./tables/adverse-events/aet02_smq.qmd)</span></span>
+<span id="cb1-33"><a href="#cb1-33"></a></span>
+<span id="cb1-34"><a href="#cb1-34"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET03 -- Adverse Events by Greatest Intensity</span><span class="co">](./tables/adverse-events/aet03.qmd)</span></span>
+<span id="cb1-35"><a href="#cb1-35"></a></span>
+<span id="cb1-36"><a href="#cb1-36"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET04 -- Adverse Events by Highest NCI CTCAE Grade</span><span class="co">](./tables/adverse-events/aet04.qmd)</span></span>
+<span id="cb1-37"><a href="#cb1-37"></a></span>
+<span id="cb1-38"><a href="#cb1-38"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET04_PI -- Adverse Events Reported in $\geq$ 10% of Patients by Highest NCI CTCAE Grade</span><span class="co">](./tables/adverse-events/aet04_pi.qmd)</span></span>
+<span id="cb1-39"><a href="#cb1-39"></a></span>
+<span id="cb1-40"><a href="#cb1-40"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET05 -- Adverse Event Rate Adjusted for Patient-Years at Risk -- First Occurrence</span><span class="co">](./tables/adverse-events/aet05.qmd)</span></span>
+<span id="cb1-41"><a href="#cb1-41"></a></span>
+<span id="cb1-42"><a href="#cb1-42"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET05_ALL -- Adverse Event Rate Adjusted for Patient-Years at Risk -- All Occurrences</span><span class="co">](./tables/adverse-events/aet05_all.qmd)</span></span>
+<span id="cb1-43"><a href="#cb1-43"></a></span>
+<span id="cb1-44"><a href="#cb1-44"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET06 -- Adverse Events by Baseline Characteristic</span><span class="co">](./tables/adverse-events/aet06.qmd)</span></span>
+<span id="cb1-45"><a href="#cb1-45"></a></span>
+<span id="cb1-46"><a href="#cb1-46"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET06_SMQ -- Adverse Events by Baseline Characteristic, by SMQ and Preferred Term</span><span class="co">](./tables/adverse-events/aet06_smq.qmd)</span></span>
+<span id="cb1-47"><a href="#cb1-47"></a></span>
+<span id="cb1-48"><a href="#cb1-48"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET07 -- Adverse Events Resulting in Death</span><span class="co">](./tables/adverse-events/aet07.qmd)</span></span>
+<span id="cb1-49"><a href="#cb1-49"></a></span>
+<span id="cb1-50"><a href="#cb1-50"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET09 -- Adverse Events Related to Study Drug</span><span class="co">](./tables/adverse-events/aet09.qmd)</span></span>
+<span id="cb1-51"><a href="#cb1-51"></a></span>
+<span id="cb1-52"><a href="#cb1-52"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET09_SMQ -- Adverse Events Related to Study Drug by Standardized MedDRA Query</span><span class="co">](./tables/adverse-events/aet09_smq.qmd)</span></span>
+<span id="cb1-53"><a href="#cb1-53"></a></span>
+<span id="cb1-54"><a href="#cb1-54"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AET10 -- Most Common ($\geq$ 5%) Adverse Events</span><span class="co">](./tables/adverse-events/aet10.qmd)</span></span>
+<span id="cb1-55"><a href="#cb1-55"></a></span>
+<span id="cb1-56"><a href="#cb1-56"></a></span>
+<span id="cb1-57"><a href="#cb1-57"></a><span class="fu">#### Concomitant Medications</span></span>
+<span id="cb1-58"><a href="#cb1-58"></a></span>
+<span id="cb1-59"><a href="#cb1-59"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CMT01 -- Concomitant Medications (GNEDrug Legacy Coding)</span><span class="co">](./tables/concomitant-medications/cmt01.qmd)</span></span>
+<span id="cb1-60"><a href="#cb1-60"></a></span>
+<span id="cb1-61"><a href="#cb1-61"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CMT01A -- Concomitant Medications by Medication Class and Preferred Name</span><span class="co">](./tables/concomitant-medications/cmt01a.qmd)</span></span>
+<span id="cb1-62"><a href="#cb1-62"></a></span>
+<span id="cb1-63"><a href="#cb1-63"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CMT01B -- Concomitant Medications by Medication Class and Preferred Name</span><span class="co">](./tables/concomitant-medications/cmt01b.qmd)</span></span>
+<span id="cb1-64"><a href="#cb1-64"></a></span>
+<span id="cb1-65"><a href="#cb1-65"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CMT02_PT -- Concomitant Medications by Preferred Name (WHODrug Coding)</span><span class="co">](./tables/concomitant-medications/cmt02_pt.qmd)</span></span>
+<span id="cb1-66"><a href="#cb1-66"></a></span>
+<span id="cb1-67"><a href="#cb1-67"></a></span>
+<span id="cb1-68"><a href="#cb1-68"></a><span class="fu">#### Deaths</span></span>
+<span id="cb1-69"><a href="#cb1-69"></a></span>
+<span id="cb1-70"><a href="#cb1-70"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DTHT01 -- Deaths</span><span class="co">](./tables/deaths/dtht01.qmd)</span></span>
+<span id="cb1-71"><a href="#cb1-71"></a></span>
+<span id="cb1-72"><a href="#cb1-72"></a></span>
+<span id="cb1-73"><a href="#cb1-73"></a><span class="fu">#### Demography</span></span>
+<span id="cb1-74"><a href="#cb1-74"></a></span>
+<span id="cb1-75"><a href="#cb1-75"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DMT01 -- Demographics and Baseline Characteristics</span><span class="co">](./tables/demography/dmt01.qmd)</span></span>
+<span id="cb1-76"><a href="#cb1-76"></a></span>
+<span id="cb1-77"><a href="#cb1-77"></a></span>
+<span id="cb1-78"><a href="#cb1-78"></a><span class="fu">#### Disclosures</span></span>
+<span id="cb1-79"><a href="#cb1-79"></a></span>
+<span id="cb1-80"><a href="#cb1-80"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DISCLOSUREST01 -- Disclosures Outputs</span><span class="co">](./tables/disclosures/disclosurest01.qmd)</span></span>
+<span id="cb1-81"><a href="#cb1-81"></a></span>
+<span id="cb1-82"><a href="#cb1-82"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EUDRAT01 -- Non-Serious Adverse Events Reported in $\geq$ 5% of Patients in Any Treatment Group -- Patients and Events</span><span class="co">](./tables/disclosures/eudrat01.qmd)</span></span>
+<span id="cb1-83"><a href="#cb1-83"></a></span>
+<span id="cb1-84"><a href="#cb1-84"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EUDRAT02 -- Serious Adverse Events, Fatal Serious Adverse Events, and Serious Adverse Events Related to Study Medication</span><span class="co">](./tables/disclosures/eudrat02.qmd)</span></span>
+<span id="cb1-85"><a href="#cb1-85"></a></span>
+<span id="cb1-86"><a href="#cb1-86"></a></span>
+<span id="cb1-87"><a href="#cb1-87"></a><span class="fu">#### Disposition</span></span>
+<span id="cb1-88"><a href="#cb1-88"></a></span>
+<span id="cb1-89"><a href="#cb1-89"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DST01 -- Patient Disposition</span><span class="co">](./tables/disposition/dst01.qmd)</span></span>
+<span id="cb1-90"><a href="#cb1-90"></a></span>
+<span id="cb1-91"><a href="#cb1-91"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PDT01 -- Major Protocol Deviations</span><span class="co">](./tables/disposition/pdt01.qmd)</span></span>
+<span id="cb1-92"><a href="#cb1-92"></a></span>
+<span id="cb1-93"><a href="#cb1-93"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PDT02 -- Major Protocol Deviations Related to Epidemic/Pandemic</span><span class="co">](./tables/disposition/pdt02.qmd)</span></span>
+<span id="cb1-94"><a href="#cb1-94"></a></span>
+<span id="cb1-95"><a href="#cb1-95"></a></span>
+<span id="cb1-96"><a href="#cb1-96"></a><span class="fu">#### ECG</span></span>
+<span id="cb1-97"><a href="#cb1-97"></a></span>
+<span id="cb1-98"><a href="#cb1-98"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGT01 -- ECG Results and Change from Baseline by Visit</span><span class="co">](./tables/ECG/egt01.qmd)</span></span>
+<span id="cb1-99"><a href="#cb1-99"></a></span>
+<span id="cb1-100"><a href="#cb1-100"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGT02 -- ECG Abnormalities (EGT02_1 &amp; EGT02_2)</span><span class="co">](./tables/ECG/egt02.qmd)</span></span>
+<span id="cb1-101"><a href="#cb1-101"></a></span>
+<span id="cb1-102"><a href="#cb1-102"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGT03 -- Shift Table of ECG Interval Data -- Baseline Versus Minimum/Maximum Post-Baseline</span><span class="co">](./tables/ECG/egt03.qmd)</span></span>
+<span id="cb1-103"><a href="#cb1-103"></a></span>
+<span id="cb1-104"><a href="#cb1-104"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGT04 -- Shift Table of Qualitative ECG Assessments</span><span class="co">](./tables/ECG/egt04.qmd)</span></span>
+<span id="cb1-105"><a href="#cb1-105"></a></span>
+<span id="cb1-106"><a href="#cb1-106"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGT05_QTCAT -- ECG Actual Values and Changes from Baseline by Visit</span><span class="co">](./tables/ECG/egt05_qtcat.qmd)</span></span>
+<span id="cb1-107"><a href="#cb1-107"></a></span>
+<span id="cb1-108"><a href="#cb1-108"></a></span>
+<span id="cb1-109"><a href="#cb1-109"></a><span class="fu">#### Efficacy</span></span>
+<span id="cb1-110"><a href="#cb1-110"></a></span>
+<span id="cb1-111"><a href="#cb1-111"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AOVT01 -- ANCOVA for Multiple End Points</span><span class="co">](./tables/efficacy/aovt01.qmd)</span></span>
+<span id="cb1-112"><a href="#cb1-112"></a></span>
+<span id="cb1-113"><a href="#cb1-113"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AOVT02 -- ANCOVA with Single End Point and Customized Table</span><span class="co">](./tables/efficacy/aovt02.qmd)</span></span>
+<span id="cb1-114"><a href="#cb1-114"></a></span>
+<span id="cb1-115"><a href="#cb1-115"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AOVT03 -- ANCOVA with Consideration of Interaction</span><span class="co">](./tables/efficacy/aovt03.qmd)</span></span>
+<span id="cb1-116"><a href="#cb1-116"></a></span>
+<span id="cb1-117"><a href="#cb1-117"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CFBT01 -- Efficacy Data and Change from Baseline by Visit</span><span class="co">](./tables/efficacy/cfbt01.qmd)</span></span>
+<span id="cb1-118"><a href="#cb1-118"></a></span>
+<span id="cb1-119"><a href="#cb1-119"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CMHT01 -- Cochran-Mantel-Haenszel (CMH) Summary</span><span class="co">](./tables/efficacy/cmht01.qmd)</span></span>
+<span id="cb1-120"><a href="#cb1-120"></a></span>
+<span id="cb1-121"><a href="#cb1-121"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">COXT01 -- Cox Regression</span><span class="co">](./tables/efficacy/coxt01.qmd)</span></span>
+<span id="cb1-122"><a href="#cb1-122"></a></span>
+<span id="cb1-123"><a href="#cb1-123"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">COXT02 -- Multivariable Cox Regression</span><span class="co">](./tables/efficacy/coxt02.qmd)</span></span>
+<span id="cb1-124"><a href="#cb1-124"></a></span>
+<span id="cb1-125"><a href="#cb1-125"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DORT01 -- Duration of Response</span><span class="co">](./tables/efficacy/dort01.qmd)</span></span>
+<span id="cb1-126"><a href="#cb1-126"></a></span>
+<span id="cb1-127"><a href="#cb1-127"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LGRT02 -- Multi-Variable Logistic Regression</span><span class="co">](./tables/efficacy/lgrt02.qmd)</span></span>
+<span id="cb1-128"><a href="#cb1-128"></a></span>
+<span id="cb1-129"><a href="#cb1-129"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MMRMT01 -- Tables for Mixed-Effect Model Repeated Measures Analysis</span><span class="co">](./tables/efficacy/mmrmt01.qmd)</span></span>
+<span id="cb1-130"><a href="#cb1-130"></a></span>
+<span id="cb1-131"><a href="#cb1-131"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ONCT05 -- Objective Response Rate by Subgroup</span><span class="co">](./tables/efficacy/onct05.qmd)</span></span>
+<span id="cb1-132"><a href="#cb1-132"></a></span>
+<span id="cb1-133"><a href="#cb1-133"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RATET01 -- Event Rate Summary for Recurrent Events</span><span class="co">](./tables/efficacy/ratet01.qmd)</span></span>
+<span id="cb1-134"><a href="#cb1-134"></a></span>
+<span id="cb1-135"><a href="#cb1-135"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RBMIT01 -- Tables for RBMI</span><span class="co">](./tables/efficacy/rbmit01.qmd)</span></span>
+<span id="cb1-136"><a href="#cb1-136"></a></span>
+<span id="cb1-137"><a href="#cb1-137"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RSPT01 -- Best Overall Response</span><span class="co">](./tables/efficacy/rspt01.qmd)</span></span>
+<span id="cb1-138"><a href="#cb1-138"></a></span>
+<span id="cb1-139"><a href="#cb1-139"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">TTET01 -- Time-To-Event Summary</span><span class="co">](./tables/efficacy/ttet01.qmd)</span></span>
+<span id="cb1-140"><a href="#cb1-140"></a></span>
+<span id="cb1-141"><a href="#cb1-141"></a></span>
+<span id="cb1-142"><a href="#cb1-142"></a><span class="fu">#### Exposure</span></span>
+<span id="cb1-143"><a href="#cb1-143"></a></span>
+<span id="cb1-144"><a href="#cb1-144"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EXT01 -- Study Drug Exposure Table</span><span class="co">](./tables/exposure/ext01.qmd)</span></span>
+<span id="cb1-145"><a href="#cb1-145"></a></span>
+<span id="cb1-146"><a href="#cb1-146"></a></span>
+<span id="cb1-147"><a href="#cb1-147"></a><span class="fu">#### Lab Results</span></span>
+<span id="cb1-148"><a href="#cb1-148"></a></span>
+<span id="cb1-149"><a href="#cb1-149"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT01 -- Laboratory Test Results and Change from Baseline by Visit</span><span class="co">](./tables/lab-results/lbt01.qmd)</span></span>
+<span id="cb1-150"><a href="#cb1-150"></a></span>
+<span id="cb1-151"><a href="#cb1-151"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT02 -- Laboratory Test Results by Visit</span><span class="co">](./tables/lab-results/lbt02.qmd)</span></span>
+<span id="cb1-152"><a href="#cb1-152"></a></span>
+<span id="cb1-153"><a href="#cb1-153"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT03 -- Laboratory Test Results Change from Baseline by Visit</span><span class="co">](./tables/lab-results/lbt03.qmd)</span></span>
+<span id="cb1-154"><a href="#cb1-154"></a></span>
+<span id="cb1-155"><a href="#cb1-155"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT04 -- Laboratory Abnormalities Not Present at Baseline</span><span class="co">](./tables/lab-results/lbt04.qmd)</span></span>
+<span id="cb1-156"><a href="#cb1-156"></a></span>
+<span id="cb1-157"><a href="#cb1-157"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT05 -- Laboratory Abnormalities with Single and Replicated Marked</span><span class="co">](./tables/lab-results/lbt05.qmd)</span></span>
+<span id="cb1-158"><a href="#cb1-158"></a></span>
+<span id="cb1-159"><a href="#cb1-159"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT06 -- Laboratory Abnormalities by Visit and Baseline Status</span><span class="co">](./tables/lab-results/lbt06.qmd)</span></span>
+<span id="cb1-160"><a href="#cb1-160"></a></span>
+<span id="cb1-161"><a href="#cb1-161"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT07 -- Laboratory Test Results with Highest NCI CTCAE Grade Post-Baseline</span><span class="co">](./tables/lab-results/lbt07.qmd)</span></span>
+<span id="cb1-162"><a href="#cb1-162"></a></span>
+<span id="cb1-163"><a href="#cb1-163"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT08 -- Laboratory Test Results with Highest NCI CTCAE Grade at Any Time</span><span class="co">](./tables/lab-results/lbt08.qmd)</span></span>
+<span id="cb1-164"><a href="#cb1-164"></a></span>
+<span id="cb1-165"><a href="#cb1-165"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT09 -- Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels</span><span class="co">](./tables/lab-results/lbt09.qmd)</span></span>
+<span id="cb1-166"><a href="#cb1-166"></a></span>
+<span id="cb1-167"><a href="#cb1-167"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT10 -- Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to ULN)</span><span class="co">](./tables/lab-results/lbt10.qmd)</span></span>
+<span id="cb1-168"><a href="#cb1-168"></a></span>
+<span id="cb1-169"><a href="#cb1-169"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT10_BL -- Liver Laboratory Tests -- Patients with Elevated Post-Baseline AST or ALT Levels at Two Consecutive Visits (with Respect to Baseline)</span><span class="co">](./tables/lab-results/lbt10_bl.qmd)</span></span>
+<span id="cb1-170"><a href="#cb1-170"></a></span>
+<span id="cb1-171"><a href="#cb1-171"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT11 -- Time to First Increase in Liver Laboratory Test Result Meeting Hy's Law Laboratory Critieria (with Respect to ULN)</span><span class="co">](./tables/lab-results/lbt11.qmd)</span></span>
+<span id="cb1-172"><a href="#cb1-172"></a></span>
+<span id="cb1-173"><a href="#cb1-173"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT11_BL -- Time to First Increase in Liver Laboratory Test Result Meeting Hy's Law Laboratory Critieria (with Respect to Baseline)</span><span class="co">](./tables/lab-results/lbt11_bl.qmd)</span></span>
+<span id="cb1-174"><a href="#cb1-174"></a></span>
+<span id="cb1-175"><a href="#cb1-175"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT12 -- Liver Laboratory Tests by Time on Treatment -- Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to ULN)</span><span class="co">](./tables/lab-results/lbt12.qmd)</span></span>
+<span id="cb1-176"><a href="#cb1-176"></a></span>
+<span id="cb1-177"><a href="#cb1-177"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT12_BL -- Liver Laboratory Tests by Time on Treatment -- Patients with Elevated Post-Baseline AST or ALT Levels (with Respect to Baseline)</span><span class="co">](./tables/lab-results/lbt12_bl.qmd)</span></span>
+<span id="cb1-178"><a href="#cb1-178"></a></span>
+<span id="cb1-179"><a href="#cb1-179"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT13 -- NCI CTCAE Grade Laboratory Abnormalities by Visit and Baseline Grade</span><span class="co">](./tables/lab-results/lbt13.qmd)</span></span>
+<span id="cb1-180"><a href="#cb1-180"></a></span>
+<span id="cb1-181"><a href="#cb1-181"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT14 -- Laboratory Test Results Shift Table -- Highest NCI CTCAE Grade Post-Baseline by Baseline NCI CTCAE Grade</span><span class="co">](./tables/lab-results/lbt14.qmd)</span></span>
+<span id="cb1-182"><a href="#cb1-182"></a></span>
+<span id="cb1-183"><a href="#cb1-183"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBT15 -- Laboratory Test Shifts to NCI CTCAE Grade 3-4 Post-Baseline</span><span class="co">](./tables/lab-results/lbt15.qmd)</span></span>
+<span id="cb1-184"><a href="#cb1-184"></a></span>
+<span id="cb1-185"><a href="#cb1-185"></a></span>
+<span id="cb1-186"><a href="#cb1-186"></a><span class="fu">#### Medical History</span></span>
+<span id="cb1-187"><a href="#cb1-187"></a></span>
+<span id="cb1-188"><a href="#cb1-188"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MHT01 -- Medical History</span><span class="co">](./tables/medical-history/mht01.qmd)</span></span>
+<span id="cb1-189"><a href="#cb1-189"></a></span>
+<span id="cb1-190"><a href="#cb1-190"></a></span>
+<span id="cb1-191"><a href="#cb1-191"></a><span class="fu">#### Pharmacokinetic</span></span>
+<span id="cb1-192"><a href="#cb1-192"></a></span>
+<span id="cb1-193"><a href="#cb1-193"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCT01 -- Summary Concentration Table</span><span class="co">](./tables/pharmacokinetic/pkct01.qmd)</span></span>
+<span id="cb1-194"><a href="#cb1-194"></a></span>
+<span id="cb1-195"><a href="#cb1-195"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT02 -- Pharmacokinetic Parameter Summary -- Plasma/Serum/Blood PK Parameters (Stats in Rows)</span><span class="co">](./tables/pharmacokinetic/pkpt02.qmd)</span></span>
+<span id="cb1-196"><a href="#cb1-196"></a></span>
+<span id="cb1-197"><a href="#cb1-197"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT03 -- Pharmacokinetic Parameter Summary of Plasma by Treatment (Stats in Columns)</span><span class="co">](./tables/pharmacokinetic/pkpt03.qmd)</span></span>
+<span id="cb1-198"><a href="#cb1-198"></a></span>
+<span id="cb1-199"><a href="#cb1-199"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT04 -- Pharmacokinetic Parameter Summary -- Urine PK Parameters (Stats in Rows)</span><span class="co">](./tables/pharmacokinetic/pkpt04.qmd)</span></span>
+<span id="cb1-200"><a href="#cb1-200"></a></span>
+<span id="cb1-201"><a href="#cb1-201"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT05 -- Summary of Urinary PK Parameters by Treatment Arm (Stats in Columns)</span><span class="co">](./tables/pharmacokinetic/pkpt05.qmd)</span></span>
+<span id="cb1-202"><a href="#cb1-202"></a></span>
+<span id="cb1-203"><a href="#cb1-203"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT06 -- Pharmacokinetic Parameter Summary -- Dose-Normalized PK Parameters (Stats in Rows)</span><span class="co">](./tables/pharmacokinetic/pkpt06.qmd)</span></span>
+<span id="cb1-204"><a href="#cb1-204"></a></span>
+<span id="cb1-205"><a href="#cb1-205"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT07 -- Table of Mean Dose-Normalized Selected Pharmacokinetic Parameters (Stats in Columns)</span><span class="co">](./tables/pharmacokinetic/pkpt07.qmd)</span></span>
+<span id="cb1-206"><a href="#cb1-206"></a></span>
+<span id="cb1-207"><a href="#cb1-207"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT08 -- Pharmacokinetic Parameter Summary of Cumulative Amount of Drug Eliminated and Cumulative Percentage of Drug Recovered (Stats in Columns)</span><span class="co">](./tables/pharmacokinetic/pkpt08.qmd)</span></span>
+<span id="cb1-208"><a href="#cb1-208"></a></span>
+<span id="cb1-209"><a href="#cb1-209"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPT11 -- Pharmacokinetic Parameter Estimated Ratios of Geometric Means and 90% Confidence Intervals for AUC and CMAX</span><span class="co">](./tables/pharmacokinetic/pkpt11.qmd)</span></span>
+<span id="cb1-210"><a href="#cb1-210"></a></span>
+<span id="cb1-211"><a href="#cb1-211"></a></span>
+<span id="cb1-212"><a href="#cb1-212"></a><span class="fu">#### Risk Management Plan</span></span>
+<span id="cb1-213"><a href="#cb1-213"></a></span>
+<span id="cb1-214"><a href="#cb1-214"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RMPT01 -- Duration of Exposure for Risk Management Plan</span><span class="co">](./tables/risk-management-plan/rmpt01.qmd)</span></span>
+<span id="cb1-215"><a href="#cb1-215"></a></span>
+<span id="cb1-216"><a href="#cb1-216"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RMPT03 -- Extent of Exposure by Age Group and Gender for Risk Management Plan</span><span class="co">](./tables/risk-management-plan/rmpt03.qmd)</span></span>
+<span id="cb1-217"><a href="#cb1-217"></a></span>
+<span id="cb1-218"><a href="#cb1-218"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RMPT04 -- Extent of Exposure by Ethnic Origin for Risk Management Plan</span><span class="co">](./tables/risk-management-plan/rmpt04.qmd)</span></span>
+<span id="cb1-219"><a href="#cb1-219"></a></span>
+<span id="cb1-220"><a href="#cb1-220"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RMPT05 -- Extent of Exposure by Race for Risk Management Plan</span><span class="co">](./tables/risk-management-plan/rmpt05.qmd)</span></span>
+<span id="cb1-221"><a href="#cb1-221"></a></span>
+<span id="cb1-222"><a href="#cb1-222"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">RMPT06 -- Seriousness, Outcomes, Severity, Frequency with 95% CI for Risk Management Plan</span><span class="co">](./tables/risk-management-plan/rmpt06.qmd)</span></span>
+<span id="cb1-223"><a href="#cb1-223"></a></span>
+<span id="cb1-224"><a href="#cb1-224"></a></span>
+<span id="cb1-225"><a href="#cb1-225"></a><span class="fu">#### Safety</span></span>
+<span id="cb1-226"><a href="#cb1-226"></a></span>
+<span id="cb1-227"><a href="#cb1-227"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ENTXX -- Enrollment Variants</span><span class="co">](./tables/safety/enrollment01.qmd)</span></span>
+<span id="cb1-228"><a href="#cb1-228"></a></span>
+<span id="cb1-229"><a href="#cb1-229"></a></span>
+<span id="cb1-230"><a href="#cb1-230"></a><span class="fu">#### Vital Signs</span></span>
+<span id="cb1-231"><a href="#cb1-231"></a></span>
+<span id="cb1-232"><a href="#cb1-232"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">VST01 -- Vital Sign Results and Change from Baseline by Visit</span><span class="co">](./tables/vital-signs/vst01.qmd)</span></span>
+<span id="cb1-233"><a href="#cb1-233"></a></span>
+<span id="cb1-234"><a href="#cb1-234"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">VST02 -- Vital Sign Abnormalities</span><span class="co">](./tables/vital-signs/vst02.qmd)</span></span>
+<span id="cb1-235"><a href="#cb1-235"></a></span>
+<span id="cb1-236"><a href="#cb1-236"></a></span>
+<span id="cb1-237"><a href="#cb1-237"></a>------------------------------------------------------------------------</span>
+<span id="cb1-238"><a href="#cb1-238"></a></span>
+<span id="cb1-239"><a href="#cb1-239"></a><span class="fu">### **Listings**</span></span>
+<span id="cb1-240"><a href="#cb1-240"></a></span>
+<span id="cb1-241"><a href="#cb1-241"></a><span class="fu">#### ADA</span></span>
+<span id="cb1-242"><a href="#cb1-242"></a></span>
+<span id="cb1-243"><a href="#cb1-243"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">ADAL02 -- Listing of Anti-Drug Antibody Data for Treatment Emergent ADA Positive Patients</span><span class="co">](./listings/ADA/adal02.qmd)</span></span>
+<span id="cb1-244"><a href="#cb1-244"></a></span>
+<span id="cb1-245"><a href="#cb1-245"></a></span>
+<span id="cb1-246"><a href="#cb1-246"></a><span class="fu">#### Adverse Events</span></span>
+<span id="cb1-247"><a href="#cb1-247"></a></span>
+<span id="cb1-248"><a href="#cb1-248"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL01 -- Listing of Preferred Terms, Lowest Level Terms, and Investigator-Specified Adverse Event Terms</span><span class="co">](./listings/adverse-events/ael01.qmd)</span></span>
+<span id="cb1-249"><a href="#cb1-249"></a></span>
+<span id="cb1-250"><a href="#cb1-250"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL01_NOLLT -- Listing of Preferred Terms and Investigator-Specified Adverse Event Terms</span><span class="co">](./listings/adverse-events/ael01_nollt.qmd)</span></span>
+<span id="cb1-251"><a href="#cb1-251"></a></span>
+<span id="cb1-252"><a href="#cb1-252"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL02 -- Listing of Adverse Events</span><span class="co">](./listings/adverse-events/ael02.qmd)</span></span>
+<span id="cb1-253"><a href="#cb1-253"></a></span>
+<span id="cb1-254"><a href="#cb1-254"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL02_ED -- Listing of Adverse Events (for Early Development Studies)</span><span class="co">](./listings/adverse-events/ael02_ed.qmd)</span></span>
+<span id="cb1-255"><a href="#cb1-255"></a></span>
+<span id="cb1-256"><a href="#cb1-256"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL03 -- Listing of Serious Adverse Events</span><span class="co">](./listings/adverse-events/ael03.qmd)</span></span>
+<span id="cb1-257"><a href="#cb1-257"></a></span>
+<span id="cb1-258"><a href="#cb1-258"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">AEL04 -- Listing of Patient Deaths</span><span class="co">](./listings/adverse-events/ael04.qmd)</span></span>
+<span id="cb1-259"><a href="#cb1-259"></a></span>
+<span id="cb1-260"><a href="#cb1-260"></a></span>
+<span id="cb1-261"><a href="#cb1-261"></a><span class="fu">#### Concomitant Medications</span></span>
+<span id="cb1-262"><a href="#cb1-262"></a></span>
+<span id="cb1-263"><a href="#cb1-263"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CML01 -- Listing of Previous and Concomitant Medications</span><span class="co">](./listings/concomitant-medications/cml01.qmd)</span></span>
+<span id="cb1-264"><a href="#cb1-264"></a></span>
+<span id="cb1-265"><a href="#cb1-265"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CML02A_GL -- Listing of Concomitant Medication Class Level 2, Preferred Name, and Investigator-Specified Terms</span><span class="co">](./listings/concomitant-medications/cml02a_gl.qmd)</span></span>
+<span id="cb1-266"><a href="#cb1-266"></a></span>
+<span id="cb1-267"><a href="#cb1-267"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CML02B_GL -- Listing of Concomitant Medication Class, Preferred Name, and Investigator-Specified Terms</span><span class="co">](./listings/concomitant-medications/cml02b_gl.qmd)</span></span>
+<span id="cb1-268"><a href="#cb1-268"></a></span>
+<span id="cb1-269"><a href="#cb1-269"></a></span>
+<span id="cb1-270"><a href="#cb1-270"></a><span class="fu">#### Disposition</span></span>
+<span id="cb1-271"><a href="#cb1-271"></a></span>
+<span id="cb1-272"><a href="#cb1-272"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DSL01 -- Listing of Patients with Study Drug Withdrawn Due to Adverse Events</span><span class="co">](./listings/disposition/dsl01.qmd)</span></span>
+<span id="cb1-273"><a href="#cb1-273"></a></span>
+<span id="cb1-274"><a href="#cb1-274"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DSL02 -- Listing of Patients Who Discontinued Early from Study</span><span class="co">](./listings/disposition/dsl02.qmd)</span></span>
+<span id="cb1-275"><a href="#cb1-275"></a></span>
+<span id="cb1-276"><a href="#cb1-276"></a></span>
+<span id="cb1-277"><a href="#cb1-277"></a><span class="fu">#### Development Safety Update Report</span></span>
+<span id="cb1-278"><a href="#cb1-278"></a></span>
+<span id="cb1-279"><a href="#cb1-279"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">DSUR4 -- Listing of Patients Who Died During Reporting Period</span><span class="co">](./listings/development-safety-update-report/dsur4.qmd)</span></span>
+<span id="cb1-280"><a href="#cb1-280"></a></span>
+<span id="cb1-281"><a href="#cb1-281"></a></span>
+<span id="cb1-282"><a href="#cb1-282"></a><span class="fu">#### ECG</span></span>
+<span id="cb1-283"><a href="#cb1-283"></a></span>
+<span id="cb1-284"><a href="#cb1-284"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EGL01 -- 'Listing of ECG Data: Safety-Evaluable Patients'</span><span class="co">](./listings/ECG/egl01.qmd)</span></span>
+<span id="cb1-285"><a href="#cb1-285"></a></span>
+<span id="cb1-286"><a href="#cb1-286"></a></span>
+<span id="cb1-287"><a href="#cb1-287"></a><span class="fu">#### Exposure</span></span>
+<span id="cb1-288"><a href="#cb1-288"></a></span>
+<span id="cb1-289"><a href="#cb1-289"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">EXL01 -- Listing of Exposure to Study Drug</span><span class="co">](./listings/exposure/exl01.qmd)</span></span>
+<span id="cb1-290"><a href="#cb1-290"></a></span>
+<span id="cb1-291"><a href="#cb1-291"></a></span>
+<span id="cb1-292"><a href="#cb1-292"></a><span class="fu">#### Lab Results</span></span>
+<span id="cb1-293"><a href="#cb1-293"></a></span>
+<span id="cb1-294"><a href="#cb1-294"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBL01 -- Listing of Laboratory Test Results</span><span class="co">](./listings/lab-results/lbl01.qmd)</span></span>
+<span id="cb1-295"><a href="#cb1-295"></a></span>
+<span id="cb1-296"><a href="#cb1-296"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBL01_RLS -- Listing of Laboratory Test Results Using Roche Safety Lab Standardization</span><span class="co">](./listings/lab-results/lbl01_rls.qmd)</span></span>
+<span id="cb1-297"><a href="#cb1-297"></a></span>
+<span id="cb1-298"><a href="#cb1-298"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBL02A -- Listing of Laboratory Abnormalities (constant units)</span><span class="co">](./listings/lab-results/lbl02a.qmd)</span></span>
+<span id="cb1-299"><a href="#cb1-299"></a></span>
+<span id="cb1-300"><a href="#cb1-300"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBL02A_RLS -- Listing of Laboratory Abnormalities Defined by Roche Safety Lab Standardization</span><span class="co">](./listings/lab-results/lbl02a_rls.qmd)</span></span>
+<span id="cb1-301"><a href="#cb1-301"></a></span>
+<span id="cb1-302"><a href="#cb1-302"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LBL02B -- Listing of Laboratory Abnormalities (variable units)</span><span class="co">](./listings/lab-results/lbl02b.qmd)</span></span>
+<span id="cb1-303"><a href="#cb1-303"></a></span>
+<span id="cb1-304"><a href="#cb1-304"></a></span>
+<span id="cb1-305"><a href="#cb1-305"></a><span class="fu">#### Medical History</span></span>
+<span id="cb1-306"><a href="#cb1-306"></a></span>
+<span id="cb1-307"><a href="#cb1-307"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MHL01 -- Listing of Medical History and Concurrent Diseases</span><span class="co">](./listings/medical-history/mhl01.qmd)</span></span>
+<span id="cb1-308"><a href="#cb1-308"></a></span>
+<span id="cb1-309"><a href="#cb1-309"></a></span>
+<span id="cb1-310"><a href="#cb1-310"></a><span class="fu">#### Pharmacokinetic</span></span>
+<span id="cb1-311"><a href="#cb1-311"></a></span>
+<span id="cb1-312"><a href="#cb1-312"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCL01 -- Listing of Drug A Concentration by Treatment Group, Patient and Nominal Time</span><span class="co">](./listings/pharmacokinetic/pkcl01.qmd)</span></span>
+<span id="cb1-313"><a href="#cb1-313"></a></span>
+<span id="cb1-314"><a href="#cb1-314"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCL02 -- Listing of Drug A Urine Concentration and Volumes</span><span class="co">](./listings/pharmacokinetic/pkcl02.qmd)</span></span>
+<span id="cb1-315"><a href="#cb1-315"></a></span>
+<span id="cb1-316"><a href="#cb1-316"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPL01 -- Listing of Drug A Plasma PK Parameters</span><span class="co">](./listings/pharmacokinetic/pkpl01.qmd)</span></span>
+<span id="cb1-317"><a href="#cb1-317"></a></span>
+<span id="cb1-318"><a href="#cb1-318"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPL02 -- Listing of Drug A Urine PK Parameters</span><span class="co">](./listings/pharmacokinetic/pkpl02.qmd)</span></span>
+<span id="cb1-319"><a href="#cb1-319"></a></span>
+<span id="cb1-320"><a href="#cb1-320"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPL04 -- Listing of Individual Drug A AUCIFO and CMAX Ratios Following Drug A or Drug B</span><span class="co">](./listings/pharmacokinetic/pkpl04.qmd)</span></span>
+<span id="cb1-321"><a href="#cb1-321"></a></span>
+<span id="cb1-322"><a href="#cb1-322"></a></span>
+<span id="cb1-323"><a href="#cb1-323"></a><span class="fu">#### Vital Signs</span></span>
+<span id="cb1-324"><a href="#cb1-324"></a></span>
+<span id="cb1-325"><a href="#cb1-325"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">VSL01 -- 'Listing of Vital Signs: Safety-Evaluable Patients'</span><span class="co">](./listings/vital-signs/vsl01.qmd)</span></span>
+<span id="cb1-326"><a href="#cb1-326"></a></span>
+<span id="cb1-327"><a href="#cb1-327"></a></span>
+<span id="cb1-328"><a href="#cb1-328"></a>------------------------------------------------------------------------</span>
+<span id="cb1-329"><a href="#cb1-329"></a></span>
+<span id="cb1-330"><a href="#cb1-330"></a><span class="fu">### **Graphs**</span></span>
+<span id="cb1-331"><a href="#cb1-331"></a></span>
+<span id="cb1-332"><a href="#cb1-332"></a><span class="fu">#### Efficacy</span></span>
+<span id="cb1-333"><a href="#cb1-333"></a></span>
+<span id="cb1-334"><a href="#cb1-334"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">FSTG01 -- Subgroup Analysis of Best Overall Response</span><span class="co">](./graphs/efficacy/fstg01.qmd)</span></span>
+<span id="cb1-335"><a href="#cb1-335"></a></span>
+<span id="cb1-336"><a href="#cb1-336"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">FSTG02 -- Subgroup Analysis of Survival Duration</span><span class="co">](./graphs/efficacy/fstg02.qmd)</span></span>
+<span id="cb1-337"><a href="#cb1-337"></a></span>
+<span id="cb1-338"><a href="#cb1-338"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MMRMG01 -- Plots for Mixed-Effect Model Repeated Measures Analysis</span><span class="co">](./graphs/efficacy/mmrmg01.qmd)</span></span>
+<span id="cb1-339"><a href="#cb1-339"></a></span>
+<span id="cb1-340"><a href="#cb1-340"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MMRMG02 -- Forest Plot for Mixed-Effect Model Repeated Measures</span><span class="co">](./graphs/efficacy/mmrmg02.qmd)</span></span>
+<span id="cb1-341"><a href="#cb1-341"></a></span>
+<span id="cb1-342"><a href="#cb1-342"></a></span>
+<span id="cb1-343"><a href="#cb1-343"></a><span class="fu">#### Pharmacokinetic</span></span>
+<span id="cb1-344"><a href="#cb1-344"></a></span>
+<span id="cb1-345"><a href="#cb1-345"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCG01 -- Plot of PK Concentration Over Time by Subject</span><span class="co">](./graphs/pharmacokinetic/pkcg01.qmd)</span></span>
+<span id="cb1-346"><a href="#cb1-346"></a></span>
+<span id="cb1-347"><a href="#cb1-347"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCG02 -- Plot of PK Concentration Over Time by Cohort/Treatment Group/Dose</span><span class="co">](./graphs/pharmacokinetic/pkcg02.qmd)</span></span>
+<span id="cb1-348"><a href="#cb1-348"></a></span>
+<span id="cb1-349"><a href="#cb1-349"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKCG03 -- Plot of Mean PK Concentration Over Time by Cohort</span><span class="co">](./graphs/pharmacokinetic/pkcg03.qmd)</span></span>
+<span id="cb1-350"><a href="#cb1-350"></a></span>
+<span id="cb1-351"><a href="#cb1-351"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPG01 -- Plot of Mean Cumulative Percentage (%) of Recovered Drug in Urine</span><span class="co">](./graphs/pharmacokinetic/pkpg01.qmd)</span></span>
+<span id="cb1-352"><a href="#cb1-352"></a></span>
+<span id="cb1-353"><a href="#cb1-353"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPG02 -- Pharmacokinetic Parameter Summary of Serum PK Parameters by Treatment</span><span class="co">](./graphs/pharmacokinetic/pkpg02.qmd)</span></span>
+<span id="cb1-354"><a href="#cb1-354"></a></span>
+<span id="cb1-355"><a href="#cb1-355"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPG03 -- Box Plot of Pharmacokinetic Parameters by Visit -- Plasma</span><span class="co">](./graphs/pharmacokinetic/pkpg03.qmd)</span></span>
+<span id="cb1-356"><a href="#cb1-356"></a></span>
+<span id="cb1-357"><a href="#cb1-357"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPG04 -- Box Plot of Pharmacokinetic Parameters by Visit -- Plasma</span><span class="co">](./graphs/pharmacokinetic/pkpg04.qmd)</span></span>
+<span id="cb1-358"><a href="#cb1-358"></a></span>
+<span id="cb1-359"><a href="#cb1-359"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">PKPG06 -- Boxplot of Metabolite to Parent Ratios by Treatment</span><span class="co">](./graphs/pharmacokinetic/pkpg06.qmd)</span></span>
+<span id="cb1-360"><a href="#cb1-360"></a></span>
+<span id="cb1-361"><a href="#cb1-361"></a></span>
+<span id="cb1-362"><a href="#cb1-362"></a><span class="fu">#### Other</span></span>
+<span id="cb1-363"><a href="#cb1-363"></a></span>
+<span id="cb1-364"><a href="#cb1-364"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">BRG01 -- Bar Chart</span><span class="co">](./graphs/other/brg01.qmd)</span></span>
+<span id="cb1-365"><a href="#cb1-365"></a></span>
+<span id="cb1-366"><a href="#cb1-366"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">BWG01 -- Box Plot</span><span class="co">](./graphs/other/bwg01.qmd)</span></span>
+<span id="cb1-367"><a href="#cb1-367"></a></span>
+<span id="cb1-368"><a href="#cb1-368"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">CIG01 -- Confidence Interval Plot</span><span class="co">](./graphs/other/cig01.qmd)</span></span>
+<span id="cb1-369"><a href="#cb1-369"></a></span>
+<span id="cb1-370"><a href="#cb1-370"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">IPPG01 -- Individual Patient Plot Over Time</span><span class="co">](./graphs/other/ippg01.qmd)</span></span>
+<span id="cb1-371"><a href="#cb1-371"></a></span>
+<span id="cb1-372"><a href="#cb1-372"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">KMG01 -- Kaplan-Meier Plot</span><span class="co">](./graphs/other/kmg01.qmd)</span></span>
+<span id="cb1-373"><a href="#cb1-373"></a></span>
+<span id="cb1-374"><a href="#cb1-374"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">LTG01 -- Lattice Plot of Laboratory Tests by Treatment Group Over Time</span><span class="co">](./graphs/other/ltg01.qmd)</span></span>
+<span id="cb1-375"><a href="#cb1-375"></a></span>
+<span id="cb1-376"><a href="#cb1-376"></a><span class="dv">&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;</span><span class="co">[</span><span class="ot">MNG01 -- Mean Plot</span><span class="co">](./graphs/other/mng01.qmd)</span></span></code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre></div>
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